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CHAPTER 3 Perineal Wound Healing After UvA-DARE (Digital Academic Repository) Management of early neoplasms and surgical complications of the rectum Musters, G.D. Publication date 2016 Document Version Final published version Link to publication Citation for published version (APA): Musters, G. D. (2016). Management of early neoplasms and surgical complications of the rectum. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (https://dare.uva.nl) Download date:11 Oct 2021 MANAGEMENT OF EARLY NEOPLASMS AND SURGICAL COMPLICATIONS OF THE RECTUM GIJSBERT MUSTERS Management of early neoplasms and surgical complications of the rectum Gijsbert D. Musters ISBN: 978-94-028-0045-6 Copyright © Gijsbert D. Musters, 2016. No parts of this thesis may be produced, stored or transmitted in any form by any means, without prior permission of the author. Financial support for the printing of this thesis was kindly provided by: Rembrandt Medical B.V., Chipsof B.V., Olympus Nederland B.V, B. Braun Medical B.V., Acelity company, Nederlandse Vereniging voor Gasteroenterologie, Tergooi ziekenhuizen,Wetenschappelijk Fonds Chirurgie AMC. Management of early neoplasms and surgical complications of the rectum ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnifcus prof. dr. D.C. van den Boom ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel op woensdag 6 april 2016, te 14:00 uur door Gijsbert Daniël Musters geboren te Huizen Promotiecommissie: Promotor: Prof. dr. W.A. Bemelman Universiteit van Amsterdam Copromotores: Dr. P.J. Tanis Universiteit van Amsterdam Prof. dr. E. Dekker Universiteit van Amsterdam Overige leden: Prof. dr. O.R.C. Busch Universiteit van Amsterdam Prof. dr. M.A. Boermeester Universiteit van Amsterdam Prof. dr. P. Fockens Universiteit van Amsterdam Prof. dr. L.P.S. Stassen Universiteit van Maastricht Dr. E.J.R. de Graaf IJsselland ziekenhuis Faculteit der Geneeskunde TABLE OF CONTENT General Introduction and outline of the thesis 7 CHAPTER 1 Endoscopic mucosal resection of large rectal adenomas in the era of 19 centralization: results of a multicenter collaboration. United European Gastroenterol J 2014; 2(6): 497-504 CHAPTER 2 Perineal wound healing afer abdominoperineal resection for rectal 33 cancer; a systematic review and meta-analysis. Dis Colon Rectum 2014; 57(9): 1129-1139 CHAPTER 3 Perineal wound problems afer abdominoperineal resection for 53 rectal cancer; a two-institutional experience in the era of intensifed oncological treatment. Int J Colorectal Dis 2014; 29(9):1151-1157 CHAPTER 4 Biological mesh closure of the pelvic foor afer extralevator 67 abdominoperineal resection for rectal cancer (BIOPEX-study). BMC Surg 2014; 27: 58 CHAPTER 5 Biological mesh closure of the pelvic foor afer extralevator 79 abdominoperineal resection for rectal cancer: a single blinded, multicentre randomised controlled trial (the BIOPEX-study). Submitted CHAPTER 6 Local application of gentamicin in the prophylaxis of perineal wound 109 infection afer abdominoperineal resection, a systematic review. World J Surg 2015; 39(11): 2786-2794 CHAPTER 7 Is there a place for a biological mesh in perineal hernia repair? 125 Submitted CHAPTER 8 Surgery for complex perineal fstula following rectal cancer treatment 139 using biological mesh combined with gluteal perforator fap. Tech Coloproctol 2014; 18(10): 955-959 CHAPTER 9 Early reconstruction of the leaking ileal pouch-anal anastomosis: a novel 149 solution to an old problem. Colorectal Dis 2015; 17(5): 426-432 CHAPTER 10 Major morbidity afer ileostomy closure: results from an institutional 161 change in practice and awareness. Int J Colorectal Dis 2016 CHAPTER 11 Intersphincteric completion proctectomy with omentoplasty for chronic 173 presacral sinus afer low anterior resection for rectal cancer. Colorectal Dis 2015 Appendices Summary and future perspectives 187 Samenvatting en toekomstige perspectieven 195 Ph.D. portfolio 203 List of publications 207 Dankwoord 213 About the author 219 General introduction and outline of the thesis General introduction and outline of the thesis 8 General introduction and outline of the thesis GENERAL INTRODUCTION Colorectal cancer (CRC) is one of the most common cancers in the world and is expected to rise from 1.4 million annually diagnosed patients worldwide in 2012 to 2.4 million patients by 2035.1 In the Netherlands, currently 13.000 new patients are diagnosed with CRC each year, of which approximately one third have rectal cancer.2 Te prognosis of patients with rectal cancer has improved signifcantly during the last two decades in the Netherlands. Te cornerstone of locoregional treatment is still surgery, and improved quality of resection as well as locally advanced rectal cancer by specialised surgical teams contributed substantially to these improvements. Tis was also facilitated by optimized pre-operative staging using MRI and the introduction of down-sizing neoadjuvant treatment. Furthermore, improvement has been achieved in the treatment of distant metastases, both by more efective systemic treatment and by increased application of local treatment modalities of liver and/or lung metastases. Further improvement of the prognosis can be expected from the recently started screening programme in the Netherlands, enabling treatment of (advanced) adenomas and early detection of rectal cancer. Rectal cancer surgery is complex and requires specifc expertise. But despite specialisation and centralisation, there is still a relatively high risk of postoperative complications. In contrast to literature on treatment of rectal cancer, prevention and treatment of short and long-term surgical complications has less extensively been explored. At the time prognosis improves, quality of life and management of treatment related morbidity becomes more and more important. Treatment of rectal cancer requires a multidisciplinary evidenced based approach, in which the treatment related morbidity has to be weighed against the expected health beneft. Treatment of rectal adenomas With the start of screening programs, adenomas are more frequently encountered.3 Early detection and removal of colorectal adenomas reduces the incidence of colorectal cancer and its associated morbidity.4 Removal of these rectal adenomas face their own therapeutic challenges. Resection of adenomas can be performed endoscopically or with microsurgery. For small adenomas, endoscopic resection can be performed by simple loop polypectomy, piecemeal endoscopic mucosal resection (EMR), or single-piece endoscopic submucosal dissection (ESD). For larger non-pedunculated adenomas, EMR is most ofen being performed. With EMR, the large rectal adenoma is submucosal lifed and snare piecemeal resection is performed. For EMR, light sedation is most ofen sufcient and no specialized equipment or overnight hospital stay is required. With transanal endoscopic microsurgery (TEM), the adenoma can be dissected submucosally or by full-thickness en bloc resection. TEM requires general anaesthesia, hospital admission and specialized instrumentation. TEM can be replaced by transanal minimally invasive surgery (TAMIS) platforms using standard laparoscopic equipment.5 Te results of TEM have been extensively reported in literature whereas data on endoscopic resection is limited for large rectal adenomas.6 9 General introduction and outline of the thesis Surgical treatment principles in rectal cancer Afer low anterior resection (LAR) following total mesorectal excision (TME) and beyond TME principles, continuity can be restored by a colo-anal anastomosis in diferent confgurations and using both stapling and hand-sewn techniques. Te decision to restore continuity depends on the sphincter function of the patient preoperatively, the distance of the tumour to the anal verge, the resection margins that can be achieved in relation to the sphincter complex and levator muscle, age and comorbidity, lower border of the radiation feld, and patient preference. When an anastomosis is not made for any reason, there are two alternatives. If the sphincter complex and pelvic foor can be preserved, the rectal stump is closed and an end colostomy is created, also referred to as a low Hartmann’s procedure. When the sphincter complex and/or levator muscle cannot be spared anymore, an abdominoperineal resection (APR) is performed. Low anterior resection with colo-anal anastomosis One of the most feared complications afer reconstructive rectal surgery is an anastomotic leakage, occurring between 6 to 20% of the patients afer LAR.7 An anastomotic leakage is a defect of the intestinal wall integrity at the anastomotic site,
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