DOCSLIB.ORG

| Mat Lade Mora Tutta La La La La Matatani Mata

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
| Mat Lade Mora Tutta La La La La Matatani Mata |MAT LADE MORA TUTTA USLA 20170239307A1 LA LA LA MATATANI MATA ( 19) United States (12 ) Patent Application Publication ( 10) Pub . No. : US 2017/ 0239307 A1 Villegas Becerril (43 ) Pub . Date : Aug. 24 , 2017 ( 54 ) COMPOSITION OF DOXYCYCLINE IN (30 ) Foreign Application Priority Data LIPOSOMES FOR THE PREVENTION , IMPROVEMENT AND /OR TREATMENT OF Sep . 23 , 2014 (ES ) .. P201431379 OCULAR PATHOLOGIES Dec . 16 , 2014 ( ES ) .. .. .. .. .. .. P201431854 Publication Classification (71 ) Applicant: AGENCIA PÚBLICA (51 ) Int. CI. EMPRESARIAL SANITARIA A61K 36 / 53 (2006 .01 ) HOSPITAL ALTO A61K 36 / 28 ( 2006 . 01 ) GUADALQUIVIR , Jaén (ES ) A61K 36 / 886 ( 2006 . 01 ) A61K 9 /00 (2006 . 01) (72 ) Inventor : Enrique Villegas Becerril, Jaén ( ES ) (52 ) U . S . CI. CPC . .. A61K 36 /53 (2013 . 01 ) ; A61K 9 /0048 (21 ) Appl . No .: 15 /513 , 493 ( 2013. 01 ) ; A61K 36 /28 ( 2013 .01 ) ; A61K 36 / 886 ( 2013 .01 ) ( 22 ) PCT Filed : Sep . 23 , 2015 ( 57 ) ABSTRACT The invention relates to use of a composition comprising (86 ) PCT No. : PCT/ ES2015 /070695 doxycycline in the production of a topically administered $ 371 ( c ) ( 1 ), medicament for the prevention , improvement and / or treat ( 2 ) Date : Mar. 22 , 2017 ment of ocular disorders . Patent Application Publication Aug . 24 , 2017 Sheet 1 of 6 US 2017 / 0239307 A1 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX ????????? ??????????????????? ?????????????????? ??????????????????? ??????????????????? ???????????????? Schirmer' s test before ? 3030 . .. treatment mi 5555555555555555555*. * * * Schirmer' s test ' after . treatment - - Linear ( Schirmer' s test before treatment) * Linear ( Schirmer' s Uppy test after 1 2 3 4 5 6 7 8 9 10 11 12 treatment) Fig . 1 Patent Application Publication Aug . 24 , 2017 Sheet 2 of 6 US 2017 / 0239307 A1 * * . 8 Dry eye questionnaire score *- before treatment -* -* -* 8 Dry eye - - -* questionnaire score - *-. after treatment .* .* *:1,117199101141* .* 1 2 3 4 5 6 7 8 9 10 11 12 .* Fig . 2 Patent Application Publication Aug . 24 , 2017 Sheet 3 of 6 US 2017 / 0239307 A1 WWW 1200 * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * = = = = = = = = = = = = = = = = = = = = = = = = = = = = 2.4*- 1000 . .- . * : ** * * * * * ** * * * * * * * * * * * * Total dry eye Total dry eye -. { { { ???? , ?? questionnaire score before treatment after teatment Fig . 3 Patent Application Publication Aug . 24 , 2017 Sheet 4 of 6 US 2017 / 0239307 A1 WWWWWWWWWWWWWWWWWWWWWWWWWWWWW * istanawi Hyperemia before treatment & Hyperemia after rrrrrrr treatment * o 1 2 3 5 6 7 8 9 10 11 12 Fig . 4 Patent Application Publication Aug . 24 , 2017 Sheet 5 of 6 US 2017 / 0239307 A1 kimli ter teatrix 20URI BIM Eto 3014604 288 SX TWO RXKINO WWWERE : : ) 20 389 : Fig . 5 Patent Application Publication Aug . 24 , 2017 Sheet 6 of 6 US 2017 / 0239307 A1 . .* . * *. * * * . 38 - * * comviriririw . .* . * * . 100 . * 682728 694 . * . * . *. * . * . * . * . * . * * $ 6 .& 55. 6 * OSDI Score before * treatment * OSDI Score after treatment * 12 5 6 8 9 10 Fig . 6 US 2017 /0239307 A1 Aug . 24 , 2017 COMPOSITION OF DOXYCYCLINE IN have already used topical doxycycline for the treatment of LIPOSOMES FOR THE PREVENTION , dry eye , although it has never been used for blepharitis IMPROVEMENT AND /OR TREATMENT OF treatment. OCULAR PATHOLOGIES 0007 ] Doxycycline has anti - infection effect and anti- in flammatory effect ( Wang et al ., 2008. Clin . Experiment. FIELD OF THE INVENTION Ophthalmol. 36 ( 1 ) , 8 - 12 ; Dursun et al. , 2008 . Am . J . Oph thalmol. 132 ( 1 ) , 8 - 13 ) . The amount of orally administered [ 0001 ] The present invention is comprised in the field of tetracycline may not reach sufficient concentration in the biology and medicine and relates to the use of doxycycline tear film where it exerts its function ( Smith et al . , 2008 . Br. for the prevention , improvement and / or treatment of ocular J. Ophthalmol. 92( 6 ), 856 - 859) . disorders . Preferably , the present invention relates to the [ 0008 ] Doxycycline has a protective effect on the walls of topical use of doxycycline in liposomes in the form of stable the microvasculature . In fact, it is used in the prevention of eye drops for the prevention , improvement and / or treatment aortic aneurysms through the inhibition of enzymes degrad of blepharitis , microthrombosis in the anterior pole and ing vessel walls . In certain groups of hemodialysis patients , chorioretinal vascular disorders . doxycycline proved to be effective in the prevention of thrombosis (Diskin et al ., 1998 . Nephron 78 , 365 - 368; Saran BACKGROUND OF THE INVENTION et al. , 2002 . Am . J . Kidney Dis . 40 , 1255 - 1263 ) . [0009 ] The protective effect of doxycycline on the vessel [0002 ] Blepharitis is one of the most common ophthalmo wall seems to be determined by metalloproteinase matrix logical diseases . It represents a wide range of acute and activity inhibition ( Sorsa et al. , 1994 . Ann . NY. Acad . Sci. chronic diseases characterized by inflammation of the free 732 , 375 -378 ) . margin of the eyelid . For both patients and ophthalmolo [0010 ] In a study conducted on rats , doxycycline was gists , this disease is very hard to understand , frustrating due capable of preventing aneurysmal dilatation without subse to its chronic nature and extremely tedious as a result of the quent signs of inflammation (Kaito et al. , 2003 . Surg. Today prolonged treatment it requires . 33, 426 -433 ) . In other work , patients taking doxycycline 10003 ] The free margin of the eyelid is the source of were found to have less vascular intimal layer proliferation inflammation which spreads to the cornea and bulbar con as well as less muscle cell migration ( Islam et al ., 2003 . Am . junctiva . This means that different types of patients are J. Pathol. 163 , 1557 -1566 ) . observed : patients with bulbar conjunctival vessel conges [0011 ] The physiopathology of diabetic retinopathy ( DR ) tion , with infiltration of the cornea and conjunctiva adnexa has yet to be fully clarified , but most authors attribute it to and pannus (vessel invasion into the peripheral cornea ) , vascular changes . In contrast , it has been recently discovered particularly in the inferior cornea . that there are changes in the glia and on a neuronal level that [ 0004 ] It is important to know the different manifestations may explain part of this physiopathology . ( Antonetti et al . , of blepharitis in order to apply suitable treatment (Raskin et 2012. N . Engl. J. Med . 366 ( 13 ) , 1227 - 1239 ) . Chronic al. , 1992 . Infect . Dis . Clin . North Am . 6 ( 4 ) , 777 -787 ) . More inflammatory changes occurring in DR in experimental than 80 agents responsible for blepharitis have been identi models include increased local nitric oxide production , fied ( Ostler, 1993 . Diseases of the external eye and adnexa , increased intracellular molecular adhesion , leukostasis and Baltimore , Williiams and Wilkins) , the most common ones increased cell expression by means of cytokines which are are Streptococus, Staphilococus, Pseudomonas, Moraxella in turn associated with tissue damage and neuronal damage and Actinomices , in addition to other not so common ones and loss ( Adamis et al. , 2008 . Semin . Immunopathol. 30 ( 2 ) , such as Anthrax , Pasteurella , Clostridium and Micobaste 65 -84 ; Tang et al ., 2011. Prog . Retin . Eye Res. 30 ( 5 ) , rium tuberculosis (Groden et al. , 1991. Cornea 10 ( 1 ) , 343 -358 ) . 50 - 53 ) . There are also other agents of viral origin (Mollus [0012 ] The microglia represents the first line of the cum contagiosum , Herpes simplex and Herpes zoster ) and immune system against attacks and usually remains inactive , fungi ( Coccidioides, Microsporum blastomices, Candida but in situations such as DR it is activated , inducing inflam and Aspergillus ) . Furthermore, there are also allergic disor matory changes (Rungger - Brändle et al. , 2000 . Invest . Oph ders ( atopy and contact dermatitis ) and other Steven - John thalmol. Vis Sci. 41 ( 7 ) , 1971 - 1980 ; Zeng et al. , 2000 . Vis son - type syndromes, ichthyosis or Lyell ’ s syndrome. Neurosci . 17 ( 3 ) , 463 -471 ; Zeng et al. , 2008 . Arch . Ophthal [ 0005 ] There are currently four blepharitis treatment alter mol. 126 ( 2 ) , 227 - 232 ; Barber et al ., 2005 . Invest Ophthalmol natives: eyelid hygiene , topical antibiotics, systemic antibi Vis Sci. 46 ( 6 ), 2210 - 2218 ; Gaucher et al . , 2007 . Vision Res . otics such as tetracyclines (Neiberg and Sowka , 2008 . 47 ( 5 ) , 612 -623 ; Ibrahim et al. , 2007. Diabetes 60 ( 4 ) , 1122 Optometry 79( 3 ) , 133 - 137) and corticosteroids. 1133; Krady et al. , 2005 . Diabetes 54 ( 5 ) , 1559 - 1565 ; Vin [0006 ] Keeping the free margin of the eyelid clean is cent et al. , 2007 . Diabetes 56 ( 1 ) :224 - 230 ) . fundamental for eliminating growing pathogens . Oral tetra [0013 ] Tetracycline and its derivatives have been proven cyclines are a fundamental complementary treatment to ease to have an anti - inflammatory effect and neuroprotective the symptoms of blepharitis (Dougherty et al. , 1991. Invest. effects , in addition to anti -bacterial effects , in cultures and in Ophthalmol . Vis . Sci. 132 ( 11 ) , 2970 - 2975 ) . Oral tetracy animal models. With respect to DR , some studies have clines are also used in certain apical corneal barrier disrup proven that doxycycline at low doses inhibits microglia tions (De Paiva et al. , 2006 . Invest. Ophthalmol. Vis . Sci . inflammatory changes , metalloproteinase activity and cell 47 ( 7 ) , 2847 - 56
Load more

Recommended publications
  • Αξιολόγηση Διαφορετικών Υποστρωμάτων Στην in Vitro Ριζοβολία Εκφύτων Αλόης (Aloe Vera L.) Για Επιχειρηματική Παραγωγή Υγιούς Πολλαπλασιαστικού Υλικού
    ΤΕΧΝΟΛΟΓΙΚΟ ΕΚΠΑΙΔΕΥΤΙΚΟ ΙΔΡΥΜΑ ΚΡΗΤΗΣ ΣΧΟΛΗ ΤΕΧΝΟΛΟΓΙΑΣ ΓΕΩΠΟΝΙΑΣ & ΤΕΧΝΟΛΟΓΙΑΣ ΤΡΟΦΙΜΩΝ ΤΜΗΜΑ ΤΕΧΝΟΛΟΓΩΝ ΓΕΩΠΟΝΩΝ Αξιολόγηση διαφορετικών υποστρωμάτων στην in vitro ριζοβολία εκφύτων αλόης (Aloe vera L.) για επιχειρηματική παραγωγή υγιούς πολλαπλασιαστικού υλικού Πτυχιακή Εργασία ΣΠΟΥΔΑΣΤΡΙΑ ΧΡΟΝΑΚΗ ΑΓΑΠΗ ΗΡΑΚΛΕΙΟ, ΑΠΡΙΛΙΟΣ 2018 ΚΑΘΗΓΗΤΕΣ ΤΡΙΜΕΛΟΥΣ ΕΞΕΤΑΣΤΙΚΗ ΕΠΙΤΡΟΠΗΣ Ομότ. Kαθ. κ. Γραμματικάκη Γαρυφαλλιά Επίκ. Καθ. κ. Δραγασάκη Μαγδαληνή Επίκ. Καθ. κ. Πασχαλίδης Κωνσταντίνος ΤΟ ΕΡΓΟ ΑΥΤΟ ΥΛΟΠΟΙΗΘΗΚΕ ΣΤΟ ΕΡΓΑΣΤΗΡΙΟ ΓΕΩΡΓΙΑΣ ΚΑΙ ΠΑΡΑΓΩΓΗΣ ΠΟΛΛΑΠΛΑΣΙΑΣΤΙΚΟΥ ΥΛΙΚΟΥ ΤΟΥ ΤΜΗΜΑΤΟΣ ΤΕΧΝΟΛΟΓΩΝ ΓΕΩΠΟΝΩΝ,ΤΗΣ ΣΧΟΛΗΣ ΤΕΧΝΟΛΟΓΙΑΣ ΓΕΩΠΟΝΙΑΣ ΤΟΥ ΤΕΙ ΚΡΗΤΗΣ 2 Πρόλογος Η παρούσα διατριβή ξεκίνησε και ολοκληρώθηκε στο Εργαστήριο Γεωργίας και Παραγωγής Πολλαπλασιαστικού Υλικού, του Τμήματος Τεχνολόγων Γεωπόνων της Σχολής Τεχνολογίας Γεωπονίας & Τεχνολογίας Τροφίμων, του ΤΕΙ Κρήτης. Με την ολοκλήρωση της συγκεκριμένης ερευνητικής εργασίας, θα ήθελα να ευχαριστήσω την Καθηγήτρια κ. Γραμματικάκη Γαρυφαλλιά, τόσο για την εμπιστοσύνη που μου έδειξε, αναθέτοντάς μου το θέμα της παρούσας μελέτης, όσο και για την βοήθεια που μου προσέφερε σε όλα τα στάδια της εκτέλεσής της. Επιπλέον, θεωρώ υποχρέωση μου να ευχαριστήσω το προσωπικό του Εργαστηρίου, κ. Κωνσταντίνα Αργυροπούλου για τη συμπαράσταση και τη φιλική της συμπεριφορά. Ευχαριστώ θερμά τον κ. Παπαδημητρίου Μιχάλη, Καθηγητή του ΤΕΙ Κρήτης, για τη χορήγηση του γενετικού υλικού έναρξης που χρησιμοποιήθηκε στην μελέτη, καθώς και τον κύριο Αλεξόπουλο Παναγιώτη, υπάλληλο της εταιρίας Hellenic Aloe, για την ευγενική
    [Show full text]
  • UNITED NATIONS EDUCATIONAL, SCIENTIFIC and CULTURAL ORGANIZATION International Coordinating Council of the Man and the Biosphere
    SC-15/CONF.227/9 Paris, 2 April 2015 Original: English UNITED NATIONS EDUCATIONAL, SCIENTIFIC AND CULTURAL ORGANIZATION International Coordinating Council of the Man and the Biosphere (MAB) Programme Twenty-seventh session UNESCO Headquarters, Paris, Room XII (Fontenoy Building) 8 – 12 June 2015 The Secretariat of the United Nations Educational Scientific and Cultural Organization (UNESCO) does not represent or endorse the accuracy or reliability of any advice, opinion, statement or other information or documentation provided by States to the Secretariat of UNESCO. The publication of any such advice, opinion, statement or other information or documentation on UNESCO’s website and/or on working documents also does not imply the expression of any opinion whatsoever on the part of the Secretariat of UNESCO concerning the legal status of any country, territory, city or area or of its boundaries. ITEM 10 OF THE PROVISIONAL AGENDA: PROPOSALS FOR NEW BIOSPHERE RESERVES AND EXTENSIONS/MODIFICATIONS TO BIOSPHERE RESERVES THAT ARE PART OF THE WORLD NETWORK OF BIOSPHERE RESERVES (WNBR) 1. Proposals for new biosphere reserves and extensions to biosphere reserves that are already part of the World Network of Biosphere Reserves (WNBR) were considered at the last meeting of the International Advisory Committee for Biosphere Reserves (IACBR), which met at UNESCO Headquarters from 2 to 5 February 2015. 2. The members of the Advisory Committee examined 26 proposals for new biosphere reserve (with 2 transboundary sites and 8 re-submissions of proposals for new biosphere reserve) and formulated their recommendations regarding specific sites in line with the recommendation categories as follows: • Nominations recommended for approval: the proposed site is recommended for approval as a biosphere reserve; no additional information is needed.
    [Show full text]
  • Plant Rescue Management Plan
    Plant Rescue Management Plan 86 MW Oya Wind Energy Facility (WEF) and associated David Hoare Consulting infrastructure between Sutherland and Matjiesfontein, Western and Northern Cape Provinces Plant Rescue Management Plan for the proposed 86 David Hoare MW Oya Wind Energy Consulting (Pty) Ltd Facility between Sutherland and Matjiesfontein in the Address: Western and Northern Cape Postnet Suite #116 Private Bag X025 Lynnwood Ridge Provinces. 0040 41 Soetdoring Avenue Lynnwood Manor Pretoria Telephone: 087 701 7629 Location: Cell: 083 284 5111 Witzenberg Local Municipality within the Cape Winelands District Fax: 086 550 2053 Municipality Email: [email protected] Prepared for Oya Energy (Pty) Ltd 5th Floor, 125 Buitengracht Street Cape Town 8001 Report author: Dr D.B. Hoare (Pr.Sci.Nat.) 13 November 2020 Report version: 1st draft i Details of specialist consultant Company name David Hoare Consulting (Pty) Ltd Registration no.: CK2017/308639/07 Address Postnet Suite #116 Private Bag X025 Lynnwood Ridge 0040 Contact person Dr David Hoare Contact details Cell: 083 284 5111 Email: [email protected] Qualifications PhD Botany (Nelson Mandela Metropolitan University) MSc Botany (University of Pretoria) BSc (Hons) Botany (Rhodes University) BSc Botany, Zoology (Rhodes University) 2 TABLE OF CONTENTS DETAILS OF SPECIALIST CONSULTANT ........................................................................................................................ 2 TABLE OF CONTENTS .................................................................................................................................................
    [Show full text]
  • Reproductive Biology of Aloe Peglerae
    THE REPRODUCTIVE BIOLOGY AND HABITAT REQUIREMENTS OF ALOE PEGLERAE, A MONTANE ENDEMIC ALOE OF THE MAGALIESBERG MOUNTAIN RANGE, SOUTH AFRICA Gina Arena 0606757V A Dissertation submitted to the Faculty of Science, University of the Witwatersrand, in fulfillment of the requirements for the degree of Master of Science Johannesburg, South Africa June 2013 DECLARATION I declare that this Dissertation is my own, unaided work. It is being submitted for the Degree of Master of Science at the University of the Witwatersrand, Johannesburg. It has not been submitted before for any degree or examination at any other University. Gina Arena 21 day of June 2013 Supervisors Prof. C.T. Symes Prof. E.T.F. Witkowski i ABSTRACT In this study I investigated the reproductive biology and pollination ecology of Aloe peglerae, an endangered endemic succulent species of the Magaliesberg Mountain Range in South Africa. The aim was to determine the pollination system of A. peglerae, the effects of flowering plant density on plant reproduction and the suitable microhabitat conditions for this species. Aloe peglerae possesses floral traits that typically conform to the bird-pollination syndrome. Pollinator exclusion experiments showed that reproduction is enhanced by opportunistic avian nectar-feeders, mainly the Cape Rock-Thrush (Monticola rupestris) and the Dark- capped Bulbul (Pycnonotus tricolor). Insect pollinators did not contribute significantly to reproductive output. Small-mammals were observed visiting flowers at night, however, the importance of these visitors as pollinators was not quantified in this study. Interannual variation in flowering patterns dictated annual flowering plant densities in the population. The first flowering season represented a typical mass flowering event resulting in high seed production, followed by a second low flowering year of low seed production.
    [Show full text]
  • Chemistry, Biological and Pharmacological Properties of African Medicinal Plants
    International Organization for Chemical Sciences in Development IOCD Working Group on Plant Chemistry CHEMISTRY, BIOLOGICAL AND PHARMACOLOGICAL PROPERTIES OF AFRICAN MEDICINAL PLANTS Proceedings of the first International IOCD-Symposium Victoria Falls, Zimbabwe, February 25-28, 1996 Edited by K. HOSTETTMANN, F. CHEVYANGANYA, M. MAIL LARD and J.-L. WOLFENDER UNIVERSITY OF ZIMBABWE PUBLICATIONS INTERNATIONAL ORGANIZATION FOR CHEMICAL SCIENCES IN DEVELOPMENT WORKING GROUP ON PLANT CHEMISTRY CHEMISTRY, BIOLOGICAL AND PHARMACOLOGICAL PROPERTIES OF AFRICAN MEDICINAL PLANTS Proceedings of the First International IOCD-Symposium Victoria Falls, Zimbabwe, February 25-28, 1996 Edited by K. HOSTETTMANN, F. CHINYANGANYA, M. MAILLARD and J.-L. WOLFENDER Inslitut de Pharmacoynosie et Phytochimie. Universite de Umsanne. PEP. Cli-1015 Lausanne. Switzerland and Department of Pharmacy. University of Zimbabwe. P.O. BoxM.P. 167. Harare. Zim babw e UNIVERSITY OF ZIMBABWE PUBLICATIONS 1996 First published in 1996 by University of Zimbabwe Publications P.O. Box MP 203 Mount Pleasant Harare Zimbabwe Cover photos. African traditional healer and Harpagophytum procumbens (Pedaliaceae) © K. Hostettmann Printed by Mazongororo Paper Converters Pvt. Ltd., Harare Contents List of contributors xiii 1. African plants as sources of pharmacologically exciting biaryl and quaternary! alkaloids 1 G. Bringnumn 2. Strategy in the search for bioactive plant constituents 21 K. Hostettmann, J.-L. Wolfender S. Rodrigue:, and A. Marston 3. International collaboration in drug discovery and development. The United States National Cancer Institute experience 43 (i.M. Cragg. M.R. Boyd. M.A. Christini, ID Maws, K.l). Mazan and B.A. Sausville 4. Tin: search for. and discovery of. two new antitumor drugs. Navelbinc and Taxotere. modified natural products 69 !' I'diee.
    [Show full text]
  • "Official Gazette of RM", No. 28/04 and 37/07), the Government of the Republic of Montenegro, at Its Meeting Held on ______2007, Enacted This
    In accordance with Article 6 paragraph 3 of the FT Law ("Official Gazette of RM", No. 28/04 and 37/07), the Government of the Republic of Montenegro, at its meeting held on ____________ 2007, enacted this DECISION ON CONTROL LIST FOR EXPORT, IMPORT AND TRANSIT OF GOODS Article 1 The goods that are being exported, imported and goods in transit procedure, shall be classified into the forms of export, import and transit, specifically: free export, import and transit and export, import and transit based on a license. The goods referred to in paragraph 1 of this Article were identified in the Control List for Export, Import and Transit of Goods that has been printed together with this Decision and constitutes an integral part hereof (Exhibit 1). Article 2 In the Control List, the goods for which export, import and transit is based on a license, were designated by the abbreviation: “D”, and automatic license were designated by abbreviation “AD”. The goods for which export, import and transit is based on a license designated by the abbreviation “D” and specific number, license is issued by following state authorities: - D1: the goods for which export, import and transit is based on a license issued by the state authority competent for protection of human health - D2: the goods for which export, import and transit is based on a license issued by the state authority competent for animal and plant health protection, if goods are imported, exported or in transit for veterinary or phyto-sanitary purposes - D3: the goods for which export, import and transit is based on a license issued by the state authority competent for environment protection - D4: the goods for which export, import and transit is based on a license issued by the state authority competent for culture.
    [Show full text]
  • Alpine Garden Society Tour Scheme 2012
    Merlin Trust – Alpine Garden Society Tour Scheme 2012 South Africa – Tour to the Eastern Cape 6th – 21st February 2012 By: Merlin recipient, Carol Hart The author photographing Crassula vaginata, Aurora Peak, Maclear For Granny Grace ii Contents Acknowledgements iv Introduction 1 The Merlin Award 1 Our Guides 1 The Tour Area 2 Map 3 The Biomes 4 The Pictures 5 Highlights of the Tour 6 Itinerary 7 A Few More Highlights 8 Conclusion 9 References 10 Ode to the Flowers of the Eastern Cape 11-12 The Tour in Pictures 13-93 iii Acknowledgements With great thanks to the Merlin Trust for enabling me to be a part of this tour to the Eastern Cape. What an eye-opening first ever botanical trip to such a diverse rich country! Huge, huge thanks to Cameron McMaster, for his passionate wealth of natural history knowledge which he so keenly and positively shares. His experience, interest and expertise at flora identification are a real inspiration and have helped to protect threatened species. His website; his photos are an amazing resource to reference (http://www.africanbulbs.com). Huge big thanks also go to Dawie Human, our other guide, whose added experience and knowledge of natural history complemented our whole tour experience of the Eastern Cape. I’d like to thank all the hosts for their hospitality and care and all the other group members who made the trip an even more memorable and enjoyable event and shared and cared for each other. Thank you to my employers, The Royal Botanic Gardens Kew, and colleagues, for being supportive and encouraging; Peter Colbourne, and Sarah Bell for helping with my IT deficiencies and lastly a loving thank you to my parents for all your invaluable support, especially for getting me to the train station in the snow! I’d like to dedicate this work in loving memory of my Gran, Grace Hart (1914-2011), whose interest in horticulture, gardens and travel was an inspiration.
    [Show full text]
  • Repertorium Plantarum Succulentarum LIV (2003) Repertorium Plantarum Succulentarum LIV (2003)
    ISSN 0486-4271 IOS Repertorium Plantarum Succulentarum LIV (2003) Repertorium Plantarum Succulentarum LIV (2003) Index nominum novarum plantarum succulentarum anno MMIII editorum nec non bibliographia taxonomica ab U. Eggli et D. C. Zappi compositus. International Organization for Succulent Plant Study Internationale Organisation für Sukkulentenforschung December 2004 ISSN 0486-4271 Conventions used in Repertorium Plantarum Succulentarum — Repertorium Plantarum Succulentarum attempts to list, under separate headings, newly published names of succulent plants and relevant literature on the systematics of these plants, on an annual basis. New names noted after the issue for the relevant year has gone to press are included in later issues. Specialist periodical literature is scanned in full (as available at the libraries at ZSS and Z or received by the compilers). Also included is information supplied to the compilers direct. It is urgently requested that any reprints of papers not published in readily available botanical literature be sent to the compilers. — Validly published names are given in bold face type, accompanied by an indication of the nomenclatu- ral type (name or specimen dependent on rank), followed by the herbarium acronyms of the herbaria where the holotype and possible isotypes are said to be deposited (first acronym for holotype), accord- ing to Index Herbariorum, ed. 8 and supplements as published in Taxon. Invalid, illegitimate, or incor- rect names are given in italic type face. In either case a full bibliographic reference is given. For new combinations, the basionym is also listed. For invalid, illegitimate or incorrect names, the articles of the ICBN which have been contravened are indicated in brackets (note that the numbering of some regularly cited articles has changed in the Tokyo (1994) edition of ICBN).
    [Show full text]
  • Mcmenamin FM
    The Garden of Ediacara • Frontispiece: The Nama Group, Aus, Namibia, August 9, 1993. From left to right, A. Seilacher, E. Seilacher, P. Seilacher, M. McMenamin, H. Luginsland, and F. Pflüger. Photograph by C. K. Brain. The Garden of Ediacara • Discovering the First Complex Life Mark A. S. McMenamin C Columbia University Press New York C Columbia University Press Publishers Since 1893 New York Chichester, West Sussex Copyright © 1998 Columbia University Press All rights reserved Library of Congress Cataloging-in-Publication Data McMenamin, Mark A. The garden of Ediacara : discovering the first complex life / Mark A. S. McMenamin. p. cm. Includes bibliographical references and index. ISBN 0-231-10558-4 (cloth) — ISBN 0–231–10559–2 (pbk.) 1. Paleontology—Precambrian. 2. Fossils. I. Title. QE724.M364 1998 560'.171—dc21 97-38073 Casebound editions of Columbia University Press books are printed on permanent and durable acid-free paper. Printed in the United States of America c 10 9 8 7 6 5 4 3 2 1 p 10 9 8 7 6 5 4 3 2 1 For Gene Foley Desert Rat par excellence and to the memory of Professor Gonzalo Vidal This page intentionally left blank Contents Foreword • ix Preface • xiii Acknowledgments • xv 1. Mystery Fossil 1 2. The Sand Menagerie 11 3. Vermiforma 47 4. The Nama Group 61 5. Back to the Garden 121 6. Cloudina 157 7. Ophrydium 167 8. Reunite Rodinia! 173 9. The Mexican Find: Sonora 1995 189 10. The Lost World 213 11. A Family Tree 225 12. Awareness of Ediacara 239 13. Revenge of the Mole Rats 255 Epilogue: Parallel Evolution • 279 Appendix • 283 Index • 285 This page intentionally left blank Foreword Dorion Sagan Virtually as soon as earth’s crust cools enough to be hospitable to life, we find evidence of life on its surface.
    [Show full text]
  • Aloe Scientific Primer International Aloe Science Council
    The International Aloe Science Council Presents an Aloe Scientific Primer International Aloe Science Council Commonly Traded Aloe Species The plant Aloe spp. has long been utilized in a variety of ways throughout history, which has been well documented elsewhere and need not be recounted in detail here, particularly as the purpose of this document is to discuss current and commonly traded aloe species. Aloe, in its various species, can presently and in the recent past be found in use as a decorative element in homes and gardens, in the creation of pharmaceuticals, in wound care products such as burn ointment, sunburn protectant and similar applications, in cosmetics, and as a food, dietary supplements and other health and nutrition related items. Recently, various species of the plant have even been used to weave into clothing and in mattresses. Those species of Aloe commonly used in commerce today can be divided into three primary categories: those used primarily in the production of crude drugs, those used primarily for decorative purposes, and those used in health, nutritional and related products. For reference purposes, this paper will outline the primary species and their uses, but will focus on the species most widely used in commerce for health, nutritional, cosmetic and supplement products, such as aloe vera. Components of aloe vera currently used in commerce The Aloe plant, and in particular aloe vera, has three distinct raw material components that are processed and found in manufactured goods: leaf juice; inner leaf juice; and aloe latex. A great deal of confusion regarding the terminology of this botanical and its components has been identified, mostly because of a lack of clear definitions, marketing, and other factors.
    [Show full text]
  • A Population Study of Aloe Peglerae in Habitat
    S. Afr. J. Bot., 1988, 54(2): 137 - 139 137 A population study of Aloe peglerae in habitat Mavis A. Scholes 20 Gavin Avenue, Pine Park, 2194 Republic of South Africa Accepted 20 October 1987 One hundred Aloe peglerae Schon I. plants were studied in habitat over a period of 10 years. Growth, flowering, seed production, mortality and recruitment were recorded. A. peglerae was found to be slow growing, with irregular flowering and seed set. Mortality and recruitment were both low. The population studied appears to be stable. Een honderd plante van Aloe peglerae Schon I. is oor 'n tydperk van 10 jaar in hulle natuurlike habitat bestudeer. Groeiwyse, blom- en saadproduksie, sterftes en aanwas is aangeteken. Daar is bevind dat A. peglerae stadig groei en ongereeld blomme en saad produseer. Die sterfte- en aanwassyfers was beide laag. Die bevolking wat bestudeer is, Iyk stabiel. Keywords: Aloe peglerae Schonl., Asphodelaceae (Liliaceae), population dynamics Introduction are exerted (Figure 1). Occasionally a plant may produce two Aloe peglerae Schonl. generally grows at an altitude in excess inflorescences simultaneously and very rarely three. of 1 500 m on the north-facing slopes of the Magaliesberg Aloe davyana grows in profusion on the lower slopes of - a quartzitic range extending 100 km between Pretoria and the Magaliesberg and the occasional hybrid between A . Rustenburg. This aloe has also been recorded on the rocky peglerae and A. davyana may be found. Aloe mutabilis grows ridges of the Witwatersrand in the Krugersdorp area but in the kloofs (ravines) in the same vicinity but flowers from urbanization has caused the destruction of many specimens.
    [Show full text]
  • Antimicrobial Activity and Qualitative Phytochemical
    ANTIMICROBIAL ACTIVITY AND QUALITATIVE PHYTOCHEMICAL COMPOSITION OF CRUDE EXTRACTS FROM MEDICINAL PLANTS AGAINST SELECTED ENTERIC BACTERIAL PATHOGENS AND Candida albicans HIBERT RACHUONYO OPINDE (BSc) I56/20520/2012 A Thesis Submitted in Partial Fulfillment of the Requirements for the Award of the Degree of Master of Science (Microbiology) in the School of Pure and Applied Sciences of Kenyatta University September 2016 i DECLARATION This thesis is my original work and has not been presented for a degree in any other University. Signature ………..……………… Date ……..…….…… Hibert Rachuonyo Opinde Department of Microbiology Kenyatta University This thesis has been submitted for examination with our approval as the University supervisors. Signature ………………………... Date.…….....…….....…. Dr. Anthony Kebira Department of Microbiology Kenyatta University Signature ……………………….. Date.……......……...….. Dr. Grace W. Gatheri Department of Plant Sciences Kenyatta University ii DEDICATION This thesis is dedicated to my parents; Noah Odek Opinde and Hilda Akinyi Opinde for their guidance and moral support since I started my education journey. iii ACKNOWLEDGEMENTS Thanks to Almighty God for this far He has brought us, his blessings and the gift of a healthy life. Despite the many challenges we have been through He has been good to us and we have been able to overcome them. I sincerely thank my supervisors; Dr. Anthony Kebira and Dr. Grace W. Gatheri for their relentless support, encouragement, relentless support and guidance during my research work. Special appreciation Professor L.E. Newton for the help and guidance offered in the process of identification of the plants. I would also like to dearly appreciate the support and input from my fellow colleagues; Philip Ogola, Japheth Wambani, Nathan Kiboi, James Kimani, Wycliffe Arika, Majorie Oruru, Christine Nakhumincha and Gilbert Koskey.
    [Show full text]