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PHC1 polyclonal antibody

Catalog: BS7896 Host: Rabbit Reactivity: Human,Mouse,Rat

BackGround: Purification&Purity: Polycomb group (PcG) assemble into multimeric The antibody was affinity-purified from rabbit antiserum complexes, which are involved in maintaining the by affinity-chromatography using epitope-specific im- transcriptional repressive state of throughout de- munogen and the purity is > 95% (by SDS-PAGE). velopment. PHC1 (polyhomeotic homolog 1), also known Applications: as EDR1, HPH1 or RAE28, is a 1,004 amino acid nuclear WB 1:500 - 1:2000 protein that is a component of the PcG multiprotein PRC1 IHC 1:50 - 1:200 complex. Specifically, the PcG PRC1 complex modifies Storage&Stability: histones, remodels chromatin and mediates monoubiq- Store at 4°C short term. Aliquot and store at -20°C long uination of Histone H2A. Other constituent proteins in- term. Avoid freeze-thaw cycles. volved in the PcG PRC1 complex are Mel-18, Bmi-1, Specificity: M33, MPc2, MPc3, RING1, Ring1b, as well as several PHC1 polyclonal antibody detects endogenous levels of others. Existing as a homodimer, PHC1 contains one PHC1 protein. FCS-type zinc finger and a SAM (sterile alpha motif) DATA: domain. PHC1 is encoded by a located on human 12, which encodes over 1,100 genes and comprises approximately 4.5% of the . Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Molecular Weight: ~ 125, 135 kDa WesternBlot (WB) analysis of PHC1 polyclonal antibody Swiss-Prot: Note: P78364 For research use only, not for use in diagnostic procedure.

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