ZIC1/2/3/4/5 Antibody Order 021-34695924 Orders@Ab-Mart.Com Support 400-6123-828 50Ul Support1@Ab-Mart.Com 100 Ul √ √ Web

TD8768 ZIC1/2/3/4/5 Antibody Order 021-34695924 [email protected] Support 400-6123-828 50ul [email protected] 100 uL √ √ Web www.ab-mart.com.cn Description: Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC- 3' (By similarity). Uniprot:Q15915 Alternative Names： Odd paired homolog Drosophila; Zic 1; ZIC; Zic family member 1 (odd-paired Drosophila homolog); Zic family member 1; Zic protein member 1; zic1; ZIC1_HUMAN; Zinc finger protein 201; Zinc finger protein of the cerebellum 1; Zinc finger protein ZIC 1; Zinc finger protein ZIC1; ZNF 201; ZNF201; HPE 5; HPE5; Odd paired homolog Drosophila; Zic 2; Zic family member 2 (odd paired Drosophila homolog); Zic family member 2; ZIC2; ZIC2_HUMAN; Zinc finger protein of the cerebellum 2; Zinc finger protein ZIC 2; Zinc finger protein Zic2; Heterotaxy 1; HTX; HTX1; ZIC 3; Zic family member 3 (odd paired Drosophila homolog heterotaxy 1); Zic family member 3; Zic3; ZIC3_HUMAN; Zinc finger protein 203; Zinc finger protein of the cerebellum 3; Zinc finger protein ZIC 3 (Zinc finger protein of the cerebellum 3); Zinc finger protein ZIC 3; ZNF203; FLJ42609; FLJ45833; Zic family member 4; ZIC4; ZIC4_HUMAN; Zinc family member 4 protein HZIC4; Zinc finger protein of cerebellum 4; Zinc finger protein of the cerebellum 4; Zinc finger protein ZIC 4; zic5; ZIC5_HUMAN; Zinc finger protein of the cerebellum 5; Zinc finger protein ZIC 5; Specificity: ZIC1/2/3/4/5 Antibody detects endogenous levels of total ZIC1/2/3/4/5. Reactivity:Human, Mouse, Rat Source:Rabbit Mol.Wt.: 55kD; 48kDa,55kDa,51kDa,37kDa,68kDa(Calculated). Storage Condition: Store at -20 °C. Stable for 12 months from date of receipt. Application: WB 1:1000-1:2000；IHC/IF 1:50-1:500.

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The Complete Genome Sequences, Unique Mutational Spectra, and Developmental Potency of Adult Neurons Revealed by Cloning
Article The Complete Genome Sequences, Unique Mutational Spectra, and Developmental Potency of Adult Neurons Revealed by Cloning Highlights Authors d Reprogramming neurons by cloning enables high-ﬁdelity Jennifer L. Hazen, Gregory G. Faust, whole-genome sequencing Alberto R. Rodriguez, ..., Sergey Kupriyanov, Ira M. Hall, d Neurons harbor 100 unique mutations but lack recurrent Kristin K. Baldwin DNA rearrangements Correspondence d Neuronal mutations impact expressed genes and exhibit unique molecular signatures [email protected] (I.M.H.), [email protected] (K.K.B.) d Mature adult neurons can generate fertile adult mouse clones In Brief Hazen et al. use cloning to amplify and perform complete genome sequence analyses on adult neurons. They discover unique characteristics of neuronal genomes consistent with postmitotic mutation and further establish neuronal genomic integrity by generating fertile mice from these neurons. Hazen et al., 2016, Neuron 89, 1223–1236 March 16, 2016 ª2016 Elsevier Inc. http://dx.doi.org/10.1016/j.neuron.2016.02.004 Neuron Article The Complete Genome Sequences, Unique Mutational Spectra, and Developmental Potency of Adult Neurons Revealed by Cloning Jennifer L. Hazen,1,8 Gregory G. Faust,2,8 Alberto R. Rodriguez,3 William C. Ferguson,1 Svetlana Shumilina,2 Royden A. Clark,2 Michael J. Boland,1 Greg Martin,3 Pavel Chubukov,1,4 Rachel K. Tsunemoto,1,5 Ali Torkamani,4 Sergey Kupriyanov,3 Ira M. Hall,6,7,* and Kristin K. Baldwin1,5,* 1Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA 2Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, 1340 Jefferson Park Avenue, Charlottesville, VA 22901, USA 3Mouse Genetics Core Facility 4Department of Integrative Structural and Computational Biology The Scripps Research Institute, 10550 N.
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ZIC1 Monoclonal Antibody (M08), Clone 1A8
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Nb600-488Af647
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Nb600-488Af488
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Product Datasheet ZIC1 Antibody NB600-488 Unit Size: 0.1 ml Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. Publications: 4 Protocols, Publications, Related Products, Reviews, Research Tools and Images at: www.novusbio.com/NB600-488 Updated 9/27/2020 v.20.1 Earn rewards for product reviews and publications. Submit a publication at www.novusbio.com/publications Submit a review at www.novusbio.com/reviews/destination/NB600-488 Page 1 of 5 v.20.1 Updated 9/27/2020 NB600-488 ZIC1 Antibody Product Information Unit Size 0.1 ml Concentration 1.0 mg/ml Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. Clonality Polyclonal Preservative 0.01% Sodium Azide Isotype IgG Purity Immunogen affinity purified Buffer PBS and 30% Glycerol Product Description Host Rabbit Gene ID 7545 Gene Symbol ZIC1 Species Human, Mouse Reactivity Notes Human and mouse. Predicted to react with rat based on 100% sequence homology. Marker Ectoderm Marker Immunogen A synthetic peptide made to an internal portion of the human Zic1 protein (between residues 20-75) [UniProt Q15915] Product Application Details Applications Western Blot, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry- Paraffin Recommended Dilutions Western Blot 1:1000, Immunohistochemistry 1:400, Immunocytochemistry/Immunofluorescence 1:10-1:500, Immunohistochemistry- Paraffin 1:400, Immunohistochemistry-Frozen Application Notes This Zic1 antibody is useful for Western Blot and Immunohistochemisty-paraffin sections. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended. Use in Immunohistochemisty-frozen sections was reported in the scientific literature (PMID: 23862012).
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ZIC1/2/3/4/5 Antibody Order 021-34695924 [email protected] Support 400-6123-828 50Ul [email protected] 100 Ul √ √ Web