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Smes in Health Research SMEs in Health Research Synopses of projects funded through the SME call for “Life sciences, genomics and biotechnology for health” project synopses project Interested in European research? Research*eu is our monthly magazine keeping you in touch with main developments (results, programmes, events, etc.). It is available in English, French, German and Spanish. A free sample copy or free subscription can be obtained from: European Commission Directorate-General for Research Communication Unit B-1049 Brussels Fax (32-2) 29-58220 E-mail: [email protected] Internet: http://ec.europa.eu/research/research-eu European Commisssion Directorate-General for Research Directorate F — Health Unit F1 — Horizontal Aspects and Coordination Contact: Ludovica Serafi ni European Commission Offi ce CDMA 2/179 B-1049 Brussels Tel. (32-2) 29-56759 Fax (32-2) 29-95888 E-mail: ludovica.serafi [email protected] EUROPEAN COMMISSION SMEs in Health Research Synopses of projects funded through the SME call for “Life sciences, genomics and biotechnology for health” (FP6-2005-LIFESCIHEALTH-7) 2008 Directorate-General for Research EUR 23457 EN Health Acknowledgements This catalogue has been produced thanks to the essential input from all project coordinators. Special thanks go to Séverine Romain for her highly professional and dynamic assistance, pivotal for the catalogue completion. I am very grateful to Rachida Ghalouchi, Christel Jaubert, Charles Kelly, Kristina Kyriakopoulou, and to all the officers in Health Directorate responsible for the projects included in this synopses, for their efficient co-operation. Finally, my warmest thanks to Stéphane Hogan, Head of Unit F1, Horizontal aspects and coordination in the Health Directorate, for the commitment and lead provided. Ludovica Serafini Editor Contact details for FP7 activities Information on FP7 Health Theme (including calls, available supports and information on SMEs and innovation): http://cordis.europa.eu/fp7/cooperation/health_en.html The SME Contact Officer in the Health Directorate is Ludovica Serafini, e-mail: [email protected] Europe Direct is a service to help you find answers to your questions about the European Union Freephone number (*): 00 800 6 7 8 9 10 11 (*) Certain mobile telephone operators do not allow access to 00 800 numbers or these calls may be billed LEGAL NOTICE Neither the European Commission nor any person acting on behalf of the Commission is responsible for the use which might be made of the following information. The views expressed in this publication are the sole responsibility of the author and do not necessarily reflect the views of the European Commission. A great deal of additional information on the European Union is available on the Internet. It can be accessed through the Europa server (http://europa.eu) and CORDIS (http://cordis.europa.eu/en/home.html) Cataloguing data can be found at the end of this publication. Luxembourg: Office for Official Publications of the European Communities, 2008 ISBN 978-92-79-08803-2 DOI 10.2777/13756 © European Communities, 2008 Reproduction is authorised provided the source is acknowledged. Printed in Luxembourg Printed on white chlorine-free paper SME CALL Table of content • Foreword . 7 • CILMALVAC . 30 The Tetrahymena system as an • Introduction . 9 innovative approach to malaria antigene expression • AGLAEA . 10 Development of novel animal models • cNEUPRO . 32 of glutamatergic central nervous Clinical Neuroproteomics system disorders using in vivo of Neurodegenerative Diseases siRNA and transgenic approaches • COBRED . 34 • ANGIOSTOP . 12 Colon and breast cancer diagnostics Novel Anti-angiogenic treatment for Cancer, Arthritis and Ocular • COMICS. 36 Neovascularization based on Comet assay and cell array for fast Inhibition of Placental Growth and efficient genotoxicity testing Factor (PlGF) • CVDIMMUNE. 38 • ARTEMIS. 14 Immunomodulation and In Vitro neural tissue system autoimmunity in cardiovascular for replacement of transgenic disease and atherosclerosis animals with memory/learning deficiencies • DEPPICT . 40 Designing Therapeutic Protein:Protein • AUTOSCREEN . 16 Inhibitors for Brain Cancer Treatments AUTOSCREEN for Cell Based High-throughput and High-content • DeZnIT . 42 Gene Function Analysis and Design of zinc metalloenzyme Drug Discovery Screens targeted drugs using an Integrated Technology approach • BacAbs . 18 Assessment of Structural • Diagnosis . 44 Requirements in Complement- Development of new and cost Mediated Bactericidal Events: effective methods for non-invasive Towards a Global Approach diagnosis of human pathogens to the Selection of New Vaccine Candidates • DIALOK . 46 Development of Innovative Assays • BioBridge. 20 and Locally acting therapies aiming Integrative Genomics and Chronic at critical Kinases in hepatic and Disease Phenotypes: modelling renal fibrosis and simulation tools for clinicians • DiaNa . 48 • CancerGrid . 22 Predictive diagnostics for diabetic Grid-aided computer system nephropathy – Novel nanotechnology for rapid anti-cancer drug design based test platforms • CAPPELLA . 26 • Drop-Top. 50 Combating cancer through novel Integration of DNA, RNA and protein approaches to protein: protein markers in a tool for the prognosis interaction inhibitor libraries and diagnosis of human disease • ChILL. 28 • EACCAD . 54 Chromatin Immuno-linked European approach to combat ligation: A novel generation of outbreaks of clostridium difficile biotechnological tools for research associated diarrhoea by development and diagnosis of new diagnostic tests 3 • ENLIGHT . 56 • IBDchip . 80 • MAMMI . 100 New molecular methods and image Usefulness of a new DNA array Mammography with molecular analysis tools for analysis of cancer (IBDchip) to predict clinical course, imaging biomarkers in situ development of complications and response to therapy in patients with • MANASP. 102 • EPIVAC . 58 inflammatory bowel disease (IBD) Development of novel management Development of a multi-step strategies for invasive aspergillosis Improved Epidermis Specific Vaccine • IMMUNATH . 82 Candidate against HIV/AIDS Translating innate immune • MEGATOOLS . 104 receptor function into diagnostic New tools for Functional Genomics • EURO-PHARMACO-GENE . 60 and therapeutic applications for based on homologous recombination Design of targeted Gene atherosclerosis induced by double-strand break and Pharmaceutics using self-assembling specific meganucleases functional entities • Immuno-PDT. 84 Immunophotodynamic therapy • MEMORIES. 106 • EXERA . 62 of cancer: concepts and applications Development, characterisation and Development of 3D in vitro models validation of new and original models of estrogen-reporter mouse tissues • INDABIP . 86 for Alzheimer’s Disease for the pharmaco-toxicological Innovative diagnostic approaches analysis of Estrogen Receptors- for biomarkers in Parkinson disease • Mimovax . 108 Interacting Compounds (ER-ICs) Alzheimer’s disease-treatment targeting • INNOVAC . 88 truncated Aβ 40/42 by active • FASTEST-TB . 66 Highly innovative strategies for immunisation Development and Clinical Evaluation vaccination to poverty related of Fast Tests for Tuberculosis Diagnosis diseases • MODEST . 110 Modular Devices for Ultrahigh- • FGENTCARD. 68 • INTELLIMAZE . 90 throughput and Small-volume Functional GENomic diagnostic High-throughput, fully automated Transfection Tools for Coronary Artery Disease and cost-effective behavioural phenotyping of normal, clinical • MUNANOVAC . 112 • GLYFDIS. 70 and genetic mouse models Mucosal Nano Vaccine Candidate Glycans in Body Fluids- Potential for HIV for Disease Diagnostics • InVitroHeart. 92 Reducing Animal Experimentation in • MYASTAID . 114 • HI-CAM . 72 Drug Testing by Human Cardiomyocyte Development of models to improve Development of a high-resolution In Vitro Models Derived from management of Myasthenia Gravis: From Anger camera for diagnosis and Embryonic Stem Cells basic knowledge to clinical application staging of cancer diseases based on state of the art detector technology • LIGHTS. 94 • MYOAMP . 116 Small ligands to interfere with Amplification of human myogenic • HighReX . 74 Thymidylate synthase dimer formation stem cells in clinical conditions High Resolution X-Ray Imaging for as new tools for development of Improved Detection and Diagnosis anticancer agents against • NanoSense . 118 of Breast Cancer ovarian carcinoma Moving sensitive immunoassays from slow and expensive to fast and • HIVResInh . 76 • liintop. 96 affordable nanoparticle-based methods Preparation and Identification of Optimisation of liver and intestine New HIV Reverse Transcriptase in vitro models for pharmacokinetics • NEOBRAIN. 120 Inhibitors Targeted Against HIV Strains and pharmacodynamics studies Neonatal estimation of brain Resistant to anti-HIV/AIDS drugs damage risk and identification • MagRSA . 98 of neuroprotectants • HIVSTOP . 78 Fully automated and integrated Development of an Effective RNA Microfluidic Platform for Real-time • Net2Drug . 122 Interference-Based Anti-HIV-1 Therapy Molecular Diagnosis of Methicillin- From gene regulatory networks Using an SV40-Derived Vector resistant Staphylococcus Aureus to drug prediction 4 • NPARI. 124 • RATstream™ . 146 • TargetHerpes . 166 Tailoring of Novel Peptide coatings European project on the Molecular intervention strategies targeting and therapeutics derived from characterisation of transgenic rat latent and lytic herpesvirus infections a newly identified component of models for neurodegenerative and the human innate immunity
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