Integumentary System the End of Summer, She Had a Golden Tan and Was Anxious to Show Off Her Hot New Look on Campus

Home , Goose bumps, Subcutaneous tissue

5 learn to Predict It was a dream job—summer days spent poolside, soaking up the sun. Following her freshman year, laura worked as a lifeguard at the country club in her hometown. by integumentary System the end of summer, she had a golden tan and was anxious to show off her hot new look on campus. However, after returning to school in the fall, she was disappointed to see that her skin kept getting lighter, t is the morning of “the big day.” You look in the mirror and, much to your dismay, and in only a few weeks it had returned to there is a big red bump on your chin. Just when you needed to look your best, this its normal pale tone. by combining your had to happen! For most people, blemish-free skin is highly desirable, and any sign i understanding of epithelial tissue from of acne is cause for embarrassment. Hair loss and crows’ feet also cause consternation chapter 4 with further information about in some people. It goes without saying that much time, effort, and money are spent on changing the appearance of the integumentary system. Think about the amount of skin structure and pigmentation in this counter space dedicated to skin care products, hair care products, and cosmetics in a chapter, explain how and why laura’s tan typical discount store. People apply lotion to their skin, color their hair, and trim their faded in the fall. nails. They try to prevent sweating by using antiperspirants and reduce or even mask body odor by washing or using deodorants and perfumes. The integumentary (in-teg-ū-men′tă-rē) system consists of the skin and accessory structures, such as hair, glands, and nails. Although people are concerned about the appearance of their integumentary system for vanity’s sake, its appearance can also Photo: The number of skin care products is amazing. indicate physiological imbalances. Some disorders, such as acne or warts, affect only The woman in this photo is shopping at a retail store that specializes in products primarily dedicated to improving the integumentary system. Other disorders affect different body parts but are reflected the appearance of the integumentary system. in the integumentary system, which provides useful signs for diagnosis. For example, reduced blood flow through the skin during a heart attack can cause a person to look pale, whereas increased blood flow as a result of fever can cause a flushed appearance. Also, some diseases cause skin rashes, such as those characteristic of measles, chicken- Module 4 pox, and allergic reactions. Integumentary System

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5.1 Functions of the integumentary the hide (skin) of an animal by removing the epidermis and pre- serving the dermis in a process called tanning. System The skin rests on the subcutaneous tissue, or hypodermis (hi-pō-der′mis), a layer of loose connective tissue (figure 5.1). The subcutaneous tissue is not part of the skin or the integumentary LEARNiNg OuTCOME system, but it does connect the skin to underlying muscle or bone. After reading this section, you should be able to Table 5.1 summarizes the structures and functions of the skin and A. Describe the general functions of the integumentary system. subcutaneous tissue.

Although we are often concerned with how the integumentary Epidermis system looks, it has many important functions that go beyond The epidermis is stratified squamous epithelium. It is separated appearance. The integumentary system forms the boundary from the underlying dermis by a basement membrane. The epidermis between the body and the external environment, thereby separating is not as thick as the dermis and contains no blood vessels. The us from the external environment while allowing us to interact with living cells of the epidermis receive nutrients and excrete waste it. Following are the major functions of the integumentary system: products by the diffusion of substances between the epidermis and 1. Protection. The skin protects against abrasion and the harmful the capillaries of the dermis (figure 5.2). effects of ultraviolet light. It also keeps microorganisms The epidermis is composed of several types of cells. Most cells from entering the body and prevents dehydration by reducing of the epidermis are called keratinocytes (ke-rat′i-nō-sītz) because water loss from the body. they produce a protein mixture called keratin (ker′ă-tin), which 2. Sensation. The integumentary system has sensory receptors makes the cells more durable. Keratinocytes give the epidermis its that can detect heat, cold, touch, pressure, and pain. ability to resist abrasion and reduce water loss. Other cells of the 3. Temperature regulation. The amount of blood flow through epidermis include melanocytes (mel′ă-nō-sītz), which contribute the skin and the activity of sweat glands help regulate body to skin color; Langerhans cells, which are part of the immune temperature. system (see chapter 22); and Merkel cells, which are specialized 4. Vitamin D production. When exposed to ultraviolet light, the epidermal cells associated with the nerve endings responsible for skin produces a molecule that can be transformed into vita- detecting light touch and superficial pressure (see chapter 14). min D, an important regulator of calcium homeostasis. New keratinocytes are produced when keratinocyte stem cells 5. Excretion. Small amounts of waste products are excreted undergo mitosis in the deepest layer of the epidermis. As new cells through the skin and glands. form, they push older cells to the surface, where they slough off. The outermost cells in this stratified arrangement protect the cells ASSESS YOuR PROgRESS underneath, and the deeper replicating cells replace cells lost from the surface. As they move from the deeper epidermal layers to the 1. Provide an example for each function of the integumentary system. surface, the keratinocytes change shape and chemical composition, through the process called keratinization (ker′ă-tin-i-zā′shŭn), 5.2 Skin where the cells accumulate keratin. During keratinization, the cells eventually die and produce an outer layer of dead, hard cells that resists abrasion and forms a permeability barrier. The study of LEARNiNg OuTCOMES keratinization is important because many skin diseases result from After reading this section, you should be able to malfunctions in this process. For example, large scales of epidermal tissue are sloughed off in psoriasis (sō-rī′ă-sis). By comparing normal A. Describe the structure and function of the epidermis. and abnormal keratinization, scientists may be able to develop B. Discuss the epidermal strata and relate them to the effective therapies for psoriasis. process of keratinization. Although keratinization is a continual process, distinct transi- C. Diﬀ erentiate between thick and thin skin as to the layers tional stages can be recognized as the cells change. On the basis of present and their locations. these stages, the many layers of cells in the epidermis are divided D. Explain the major factors aﬀ ecting skin color. into regions, or strata (sing. stratum; see figures 5.2b and 5.3). E. Describe the structure and functions of the dermis. From the deepest to the most superficial, the five strata are the stratum basale, stratum spinosum, stratum granulosum, stratum The skin is made up of two major tissue layers, the epidermis and lucidum, and stratum corneum. The number of cell layers in each the dermis (figure 5.1). The epidermis (ep-i-der′mis; upon the stratum and even the number of strata in the skin vary, depending dermis) is the superficial layer of the skin, consisting of epithelial on their location in the body. tissue. The epidermis resists abrasion on the skin’s surface and reduces water loss through the skin. The epidermis rests on the Stratum Basale dermis (der′mis; skin), a layer of connective tissue. The dermis The deepest portion of the epidermis is a single layer of cuboidal is responsible for most of the structural strength of the skin. The or columnar cells called the stratum basale (bā′să-lē), or stratum strength of the dermis is seen in leather, which is produced from germinativum (jer′mi-nă-tīv′um; figure 5.3, stratum 1). Structural

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Hairs

Epidermis

Sebaceous gland Skin

Arrector pili Dermis (smooth muscle)

Hair follicle Nerve Vein Subcutaneous Artery tissue (hypodermis) Sweat gland Adipose tissue

FiguRE 5.1 Skin and Subcutaneous Tissue The skin, consisting of the epidermis and the dermis, is connected by the subcutaneous tissue to underlying structures. Note the accessory structures (hairs, glands, and arrector pili), some of which project into the subcutaneous tissue, as well as the large amount of adipose tissue in the subcutaneous tissue.

strength is provided by hemidesmosomes, which anchor the Stratum Granulosum epidermis to the basement membrane, and by desmosomes, which The stratum granulosum (gran-ū-lō′sŭm) consists of two to five lay- hold the keratinocytes together (see chapter 4). Keratinocytes are ers of somewhat flattened, diamond-shaped cells with long axes that strengthened internally by keratin fibers (intermediate filaments) are oriented parallel to the surface of the skin (figure 5.3, stratum 3). that insert into the desmosomes. Keratinocyte stem cells of the This stratum derives its name from the presence of nonmembrane- stratum basale undergo mitotic divisions approximately every bound protein granules of keratohyalin (ker′ă-tō-hī′ă-lin), which 19 days. One daughter cell remains a stem cell in the stratum accumulate in the cytoplasm of the cell. The lamellar bodies, formed basale and divides again, but the other daughter cell is pushed as the cells pass through the stratum spinosum, move to the plasma toward the surface and becomes keratinized. It takes approxi- membrane and release their lipid contents into the extracellular mately 40–56 days for the cell to reach the epidermal surface and space. Inside the cell, a protein envelope forms beneath the plasma slough off. membrane. In the most superficial layers of the stratum granulosum, the nucleus and other organelles degenerate, and the cell dies. Unlike Stratum Spinosum the other organelles and the nucleus, however, the keratin fibers and Superficial to the stratum basale is the stratum spinosum keratohyalin granules within the cytoplasm do not degenerate. (spī-nō′sŭm), consisting of 8–10 layers of many-sided cells (figure 5.3, stratum 2). As the cells in this stratum are pushed to the Stratum Lucidum surface, they flatten; desmosomes break apart, and new The stratum lucidum (loo′si-dŭm) appears as a thin, clear zone desmosomes form. During preparation for microscopic observa- above the stratum granulosum (figure 5.3, stratum 4); it consists of tion, the cells usually shrink from one another, except where they several layers of dead cells with indistinct boundaries. Keratin fibers are attached by desmosomes, causing the cells to appear spiny— are present, but the keratohyalin, which was evident as granules in the hence the name stratum spinosum. Additional keratin fibers and stratum granulosum, has dispersed around the keratin fibers, and the lipid-filled, membrane-bound organelles called lamellar (lam′ĕ- cells appear somewhat transparent. The stratum lucidum is present in lăr, lă-mel′ar) bodies form inside the keratinocytes. only a few areas of the body (see the section “Thick and Thin Skin”).

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Table 5.1 Comparison of the Skin (Epidermis and Dermis) and Subcutaneous Tissue

Part Structure Function Epidermis Superficial part of skin; stratified squamous Prevents water loss and the entry of chemicals and microorganisms; epithelium; composed of four or five strata protects against abrasion and harmful effects of ultraviolet light; produces vitamin D; gives rise to hair, nails, and glands Stratum corneum Most superficial stratum of the epidermis; 25 or Provides structural strength due to keratin within cells; prevents water more layers of dead squamous cells loss due to lipids surrounding cells; sloughing off of most superficial cells resists abrasion Stratum lucidum Three to five layers of dead cells; appears transparent; Disperses keratohyalin around keratin fibers present in thick skin, absent in most thin skin Stratum granulosum Two to five layers of flattened, diamond-shaped cells Produces keratohyalin granules; lamellar bodies release lipids from cells; cells die Stratum spinosum A total of 8–10 layers of many-sided cells Produces keratin fibers; lamellar bodies form inside keratinocytes Stratum basale Deepest stratum of the epidermis; single layer of Produces cells of the most superficial strata; melanocytes produce and cuboidal or columnar cells; basement membrane contribute melanin, which protects against ultraviolet light of the epidermis attaches to the dermis Dermis Deep part of skin; connective tissue composed of Is responsible for the structural strength and flexibility of the skin; the two layers epidermis exchanges gases, nutrients, and waste products with blood vessels in the dermis Papillary layer Papillae project toward the epidermis; loose Brings blood vessels close to the epidermis; dermal papillae form connective tissue fingerprints and footprints Reticular layer Mat of collagen and elastic fibers; dense irregular Is the main fibrous layer of the dermis; strong in many directions; forms connective tissue cleavage lines Subcutaneous tissue Not part of the skin; loose connective tissue with Attaches the dermis to underlying structures; adipose tissue provides abundant deposits of adipose tissue energy storage, insulation, and padding; blood vessels and nerves from the subcutaneous tissue supply the dermis

Stratum Corneum The last, and most superficial, stratum of the epidermis is the stratum Thick and Thin Skin corneum (kōr′nē-ŭm; figure 5.3, stratum 5). This stratum is com- When we say a person has thick or thin skin, we are usually referring posed of 25 or more layers of dead, overlapping squamous cells metaphorically to the person’s ability to take criticism. However, joined by desmosomes. Eventually, the desmosomes break apart, in a literal sense all of us have both thick and thin skin. Skin is and the cells are shed from the surface of the skin. Excessive shed- classified as thick or thin based on the structure of the epidermis. ding of the stratum corneum of the scalp results in dandruff. Less Thick skin has all five epithelial strata, and the stratum corneum noticeably, skin cells are continually shed from other areas as has many layers of cells. Thick skin is found in areas subject to clothes rub against the body or as the skin is washed. pressure or friction, such as the palms of the hands, the soles of The stratum corneum consists of cornified cells, which are dead the feet, and the fingertips. cells, with a hard protein envelope, filled with the protein keratin. Thin skin covers the rest of the body and is more flexible than Keratin is a mixture of keratin fibers and keratohyalin. The enve- thick skin. Each of its strata contains fewer layers of cells than are lope and the keratin are responsible for the structural strength of found in thick skin; the stratum granulosum frequently consists of the stratum corneum. The type of keratin found in the skin is soft only one or two layers of cells, and the stratum lucidum is generally keratin. Another type of keratin, hard keratin, is found in nails and absent. Hair is found only in thin skin. the external parts of hair. Cells containing hard keratin are more The entire skin, including both the epidermis and the dermis, durable than cells with soft keratin, and they are not shed. varies in thickness from 0.5 mm in the eyelids to 5.0 mm on the Lipids are released from lamellar bodies surrounding the skin back and shoulders. The terms thin and thick, which refer to the cells. The lipids are responsible for many of the skin’s permeability epidermis only, should not be used when total skin thickness is characteristics. considered. Most of the difference in total skin thickness results from variation in the thickness of the dermis. For example, the skin Predict 2 of the back is thin skin, whereas that of the palm of the hand is thick Some drugs are administered by applying them to the skin (e.g., a nicotine skin; however, because the dermis of the skin of the back is thicker, skin patch to help a person stop smoking). The drug diffuses through the the total skin thickness of the back is greater than that of the palm. epidermis to blood vessels in the dermis. What kind of substances can pass In skin subjected to friction or pressure, the number of layers easily through the skin by diffusion? What kinds of substances have difficulty in the stratum corneum greatly increases to produce a thickened diffusing through the skin? area called a callus (kal′ŭs). The skin over bony prominences may

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Epidermis

Dermal papilla

Stratum corneum

Stratum lucidum Stratum granulosum

Stratum spinosum

Epidermis Stratum basale

Papilla Dermal papilla extending into the epidermis Papillary layer of dermis

(a) LM 40x (b) LM 500x

Figure 5.2 Dermis and Epidermis (a) Photomicrograph of the dermis covered by the epidermis. The dermis consists of the papillary and reticular layers. The papillary layer has projections, called papillae, that extend into the epidermis. (b) Higher-magnification photomicrograph of the epidermis resting on the papillary layer of the dermis. Note the strata of the epidermis.

develop a cone-shaped structure called a corn. The base of the cone (figure 5.4). The Golgi apparatuses of the melanocytes package is at the surface, but the apex extends deep into the epidermis, and melanin into vesicles called melanosomes (mel′ă-nō-sōmz), which pressure on the corn may be quite painful. Calluses and corns can move into the cell processes of the melanocytes. Keratinocytes develop in both thin and thick skin. phagocytize (see chapter 3) the tips of the melanocyte cell processes, thereby acquiring melanosomes. Although all keratinocytes can contain melanin, only the melanocytes produce it. Skin Color To produce melanin, the enzyme tyrosinase (tī′rō-si-nās, The factors that determine skin color include pigments in the tir′ō-si-nās) converts the amino acid tyrosine to dopaquinone skin, blood circulating through the skin, and the thickness of the (dō′pă-kwin′ōn, dō′pă-kwī-nōn). Dopaquinone can be converted stratum corneum. Melanin (mel′ă-nin) is the group of pigments to a variety of related molecules, most of which are brown to black primarily responsible for skin, hair, and eye color. Melanin also pigments but some of which are yellowish or reddish. provides protection against ultraviolet light from the sun. Large Melanin production is determined by genetic factors, exposure amounts of melanin are found in certain regions of the skin, such to light, and hormones. Genetic factors are primarily responsible as freckles, moles, the nipples, the areolae of the breasts, the axillae, for the variations in skin color among different races and among and the genitalia. Other areas of the body, such as the lips, palms people of the same race. Since all races have about the same number of the hands, and soles of the feet, contain less melanin. of melanocytes, racial variations in skin color are determined by Melanin is produced by melanocytes (mel′ă-nō-sītz), irregu- the amount and types of melanin produced by the melanocytes, larly shaped cells with many long processes that extend between the as well as by the size, number, and distribution of the melanosomes. keratinocytes of the stratum basale and the stratum spinosum Although many genes are responsible for skin color, a single mutation

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Superficial

Direction of cell movement Intercellular lipids

5 In the stratum corneum, the dead cells Keratin have a hard protein envelope, contain 5 Stratum keratin, and are surrounded by lipids. corneum Lamellar body releases lipids. 4 In the stratum lucidum, the cells are dead Stratum Protein envelope and contain dispersed keratohyalin. 4 lucidum

Stratum Keratohyalin In the stratum granulosum, keratohyalin 3 3 granulosum granules granules accumulate, and a hard protein envelope forms beneath the plasma Lipid-filled membrane; lamellar bodies release lipids; lamellar body cells die. Keratin fiber Stratum 2 spinosum 2 In the stratum spinosum, keratin fibers and Desmosome lamellar bodies accumulate.

Nucleus 1 Stratum 1 In the stratum basale, cells divide by basale Hemidesmosome mitosis, and some of the newly formed cells become the cells of the more Basement superficial strata. Deep membrane

PROCESS FiguRE 5.3 Epidermal Layers and keratinization

(see chapter 29) can prevent the manufacture of melanin. Albinism areolae, and genitalia. The cheekbones, forehead, and chest also may (al′bi-nizm) is usually a recessive genetic trait that results from an darken, resulting in the “mask of pregnancy,” and a dark line of inability to produce tyrosinase. The result is a deficiency or an pigmentation may appear on the midline of the abdomen. Diseases absence of pigment in the skin, the hair, and the irises of the eyes. that cause increased secretion of adrenocorticotropic hormone and Exposure to ultraviolet light darkens the melanin already present in melanocyte-stimulating hormone, such as Addison disease, also the skin and stimulates melanin production, resulting in tanning. cause increased pigmentation. During pregnancy, certain hormones, such as estrogen and Blood flowing through the skin imparts a reddish hue, a con- melanocyte-stimulating hormone, cause the mother’s body to dition called erythema (er-ĭ-thē′mă). An inflammatory response increased melanin production, which causes darkening of the nipples, (see chapter 4) stimulated by infection, sunburn, allergic reactions,

1 Melanosomes are produced by the Golgi apparatus of the melanocyte. 2 Melanosomes move into melanocyte cell processes. 3 Epithelial cells phagocytize the tips of the melanocyte cell processes.

4 The melanosomes, which were 4 Epithelial cell 3 produced inside the melanocytes, have been transferred to epithelial Melanocyte 2 cells and are now inside them. Melanosomes

Nucleus 1

Golgi apparatus

PROCESS FiguRE 5.4 Melanin Transfer to keratinocytes Melanocytes make melanin, which is packaged into melanosomes and transferred to many keratinocytes.

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insect bites, or other causes can produce erythema, as can expo- The dermis is divided into two layers (see figure 5.2a): the sure to the cold and blushing or flushing when angry or hot. A superficial papillary (pap′i-lār-ē) layer and the deeper reticular decrease in blood flow, as occurs in shock, can make the skin appear (re-tik′ū-lăr) layer. The papillary layer derives its name from pale, and a decrease in the blood oxygen content produces cyanosis projections, called dermal papillae (pă-pil′ē), that extend toward (sī-ă-nō′sis), a bluish skin color (see Clinical Impact, “The the epidermis. The papillary layer is loose connective tissue with Integumentary System as a Diagnostic Aid,” later in this chapter). thin fibers that are somewhat loosely arranged. The papillary Carotene (kar′ō-tēn) is a yellow pigment found in plants, layer also contains blood vessels that supply the overlying epider- such as carrots and corn. Humans normally ingest carotene and mis with oxygen and nutrients, remove waste products, and aid in use it as a source of vitamin A. Carotene is lipid-soluble and, when regulating body temperature. large amounts of carotene are consumed, the excess accumulates The dermal papillae under the thick skin of the palms of the in the stratum corneum and in adipocytes of the dermis and sub- hands and soles of the feet lie in parallel, curving ridges that shape cutaneous tissue, causing the skin to develop a yellowish tint. The the overlying epidermis into fingerprints and footprints. The ridges yellowish tint slowly disappears once carotene intake is reduced. increase friction and improve the grip of the hands and feet. Everyone The location of pigments and other substances in the skin has unique fingerprints and footprints, even identical twins. affects the color produced. For example, light reflected off dark The reticular layer, which is composed of dense irregular pigment in the dermis or subcutaneous tissue can be scattered by connective tissue, is the main layer of the dermis. It is continu- collagen fibers of the dermis to produce a blue color. The same ous with the subcutaneous tissue and forms a mat of irregularly effect produces the blue color of the sky as light is reflected from arranged fibers that are resistant to stretching in many directions. dust particles in the air. The deeper within the dermis or subcuta- The elastic and collagen fibers are oriented more in some direc- neous tissue any dark pigment is located, the bluer the pigment tions than in others and produce cleavage lines, or tension lines, appears because of the light-scattering effect of the overlying tis- in the skin (figure 5.5). It is important for health professionals sue. This effect causes the blue color of tattoos, bruises, and some to understand cleavage line directions because an incision made superficial blood vessels.

ASSESS YOuR PROgRESS 2. From deepest to most superfi cial, name and describe the fi ve strata of the epidermis. In which stratum are new cells formed by mitosis? Which strata have live cells, and which strata have dead cells? 3. Describe the structural features resulting from keratinization that make the epidermis structurally strong and resistant to water loss. 4. Compare the structure and location of thick and thin skin. Is hair in thick or thin skin? An incision made across cleavage lines can gap, 5. Which cells of the epidermis produce melanin? What happens increasing the time needed to the melanin once it is produced? for healing and resulting in increased scar tissue 6. How do genetic factors, exposure to sunlight, and hormones formation. determine the amount of melanin in the skin? 7. How do carotene, blood fl ow, oxygen content, and collagen aff ect skin color?

Dermis The dermis is connective tissue containing fibroblasts, a few adipocytes, and macrophages. Collagen is the main connective tissue fiber, but elastic and reticular fibers are also present. Adipocytes and blood vessels are scarce in the dermis compared with the subcutaneous tissue. The dermis contains nerve endings, hair follicles, smooth muscles, glands, and lymphatic vessels (see figure 5.1). An incision made parallel to cleavage The nerve endings are varied in structure and function. They include lines results in less gapping, faster healing, and less scar tissue. free nerve endings for pain, itch, tickle, and temperature sensations; hair follicle receptors for light touch; Pacinian corpuscles for deep pressure; Meissner corpuscles for detecting simultaneous stimulation FiguRE 5.5 Cleavage Lines at two points on the skin; and Ruffini end organs for sensing con- The orientation of collagen fibers produces cleavage lines, or tension lines, tinuous touch or pressure (see figure 14.1). in the skin.

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Clinical GeNeTICS Skin Cancer

kin cancer is the most common type of Genetics, “Genetic Changes in Cancer Cells,” exposed to sunlight, such as the face, neck, cancer. Most skin cancers result from in chapter 3). ears, and dorsum of the forearm and hand. A Sdamage caused by the ultraviolet (UV) The amount of protective melanin in the physician should be consulted if skin cancer radiation in sunlight. Some skin cancers are skin affects the likelihood of developing skin is suspected. induced by chemicals, x-rays, depression of cancer. Fair-skinned individuals, who have less There are three types of skin cancer: basal the immune system, or inflammation, whereas melanin, are at an increased risk of develop- cell carcinoma, squamous cell carcinoma, and others are inherited. ing skin cancer compared with dark-skinned melanoma (figure 5A). Basal cell carcinoma, UV radiation damages the genes (DNA) individuals, who have more melanin. Long- the most common type, affects cells in the stra- in epidermal cells, producing mutations. If term or intense exposure to UV radiation also tum basale. Basal cell carcinomas have a varied a mutation is not repaired, the mutation is increases the risk. Thus, individuals who are appearance. Some are open sores that bleed, passed to one of the two daughter cells when older than 50, who have engaged in repeated ooze, or crust for several weeks. Others are a cell divides by mitosis. If mutations affect- recreational or occupational exposure to the reddish patches; shiny, pearly, or translucent ing oncogenes and tumor suppressor genes in sun, or who have experienced sunburn are bumps; or scarlike areas of shiny, taut skin. epidermal cells accumulate, uncontrolled cell at increased risk. Most skin cancers develop Removal or destruction of the tumor cures division and skin cancer can result (see Clinical on the parts of the body that are frequently most cases.

(a) Basal cell carcinoma (b) Squamous cell carcinoma (c) Melanoma

FiguRE 5A Cancer of the Skin

parallel to the cleavage lines is less likely to gap than an incision 5.3 Subcutaneous Tissue made across them. The development of infections and the formation of scar tissue are reduced in wounds where the edges are closer together. LEARNiNg OuTCOME If the skin is overstretched, the dermis may rupture and After reading this section, you should be able to leave lines that are visible through the epidermis. These lines of scar tissue, called stretch marks, can develop on the abdo- A. Describe the structure and functions of the subcutaneous men and breasts of a woman during pregnancy or on the skin tissue underlying the skin. of athletes who have quickly increased muscle size by intense weight training. Just as a house rests on a foundation, the skin rests on subcutaneous tissue, which attaches it to underlying bone and muscle and supplies ASSESS YOuR PROgRESS it with blood vessels and nerves (see figure 5.1). The subcutaneous tissue consists of loose connective tissue with collagen and elastic 8. Name and compare the two layers of the dermis. Which layer is fibers. The main types of cells within the subcutaneous tissue are responsible for most of the structural strength of the skin? fibroblasts, adipocytes, and macrophages. The subcutaneous tissue, 9. What are formed by the dermal papillae in thick skin? What roles which is not part of the skin, is sometimes called the hypodermis . do they have? Approximately half the body’s stored lipids are in the subcuta- 10. What are cleavage lines, and how are they related to the healing neous tissue, where they function in insulation and padding and as of a cut? a source of energy. The subcutaneous tissue can be used to estimate

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Squamous cell carcinoma is the second not uniform), D is for diameter (greater than metastasizing melanoma cells it is reactivated. most common type of skin cancer. Squamous 6 mm), and E is for evolving (lesion changes The reactivation of embryonic genes, such as cell carcinoma affects cells in the stratum over time). Evolving lesions change size, shape, Slug, may also play a role in other metasta- spinosum and can appear as a wartlike growth; elevation, or color; they may bleed, crust, itch, sizing cancers. a persistent, scaly red patch; an open sore; or or become tender. Most skin cancers result from a series an elevated growth with a central depression. In order for cancer cells to metastasize, they of genetic changes in somatic cells. Some These lesions may bleed. Removal or destruc- must leave their site of origin, enter the circula- people, however, have a genetic susceptibility tion of the tumor cures most cases. tion, and become established in a new loca- to developing skin cancer. Xeroderma pig- Melanoma (mel′ă-nō′mă) is the least tion. For example, melanoma cells first spread mentosum (zēr′ō-der′mă pig′men-tō′sŭm) is common, but most deadly, type of skin cancer, within the epidermis. Some of those cells may a rare inherited disorder in which a DNA accounting for over 77% of the skin cancer then break through the basement membrane repair gene is defective. Because damage to deaths in the United States. Because they arise and invade the dermis; from there, they may genes by UV radiation is not repaired, expo- from melanocytes, most melanomas are black enter lymphatic or blood vessels and spread to sure to UV radiation results in the development or brown, but occasionally a melanoma stops other parts of the body. The ability of cancer of fatal skin cancers in childhood. Limiting producing melanin and appears skin-colored, cells to metastasize requires an accumulation of exposure to the sun and using sunscreens can pink, red, or purple. About 40% of melano- mutations that enables the cells to detach from reduce everyone’s likelihood of developing skin mas develop in preexisting moles. Treatment similar cells, recognize and digest the basement cancer, especially those who have a genetic of melanomas when they are confined to membrane, and become established elsewhere susceptibility. Two types of UV radiation play the epidermis is almost always successful. when surrounded by different cell types. a role. Ultraviolet-B (UVB; 290–320 nm) However, if a melanoma invades the dermis Basal cell carcinomas very rarely metas- radiation is the most potent for causing sun- and metastasizes to other parts of the body, it tasize, and only 2–6% of squamous cell car- burn; it is also the main cause of basal and is difficult to treat and can be deadly. cinomas metastasize. Compared with kerati- squamous cell carcinomas and a significant Early detection and treatment of melanocytes, melanocytes are more likely to give cause of melanoma. Ultraviolet-A (UVA; noma before it metastasizes can prevent death. rise to tumors that metastasize because, in their 320–400 nm) also contributes to skin cancer Melanoma can be detected by routine examina- developmental past, they had the ability to development, especially melanoma. It, too, tion of the skin and application of the ABCDE migrate and become established in new loca- penetrates the dermis, causing wrinkling and rule, which states the signs of melanoma: A tions. In the embryo, melanocytes are derived leathering of the skin. The Skin Cancer stands for asymmetry (one side of the lesion from a population of cells called neural crest Foundation recommends using a broad- does not match the other side), B is for border cells (see chapter 13). A gene called Slug spectrum sunscreen that protects against both irregularity (the edges are ragged, notched, regulates neural crest cell migration. In normal UVB and UVA, with a sun protection factor or blurred), C is for color (pigmentation is melanocytes, the Slug gene is inactive, but in (SPF) of at least 15.

total body fat by pinching the skin at selected locations and mea- suring the thickness of the skin fold and underlying subcutaneous Clinical tissue. The thicker the fold, the greater the amount of total body fat. The amount of adipose tissue in the subcutaneous tissue varies IMPaCT with age, sex, and diet. Most babies have a chubby appearance because they have proportionately more adipose tissue than adults. injections Women have proportionately more adipose tissue than men, njections are used to introduce certain substances, such as medi- especially over the thighs, buttocks, and breasts, which accounts cation and vaccines, into the body. Th ere are three types of injec- for some of the differences in body shape between women and men. Itions. An intradermal injection, as is used for the tuberculin skin The amount of adipose tissue in the subcutaneous tissue is also test, goes into the dermis. It is administered by drawing the skin responsible for some of the differences in body shape between taut and inserting a small needle at a shallow angle into the skin. A individuals of the same sex. subcutaneous injection extends into the subcutaneous tissue; an insulin injection is one example. A subcutaneous injection is ASSESS YOuR PROgRESS achieved by pinching the skin to form a “tent” into which a short needle is inserted. An intramuscular injection reaches a muscle 11. Name the types of tissue forming the subcutaneous tissue layer. deep to the subcutaneous tissue. It is accomplished by inserting a 12. How is the subcutaneous tissue related to the skin? long needle at a 90-degree angle to the skin. Intramuscular injec- 13. List the functions of the adipose tissue within the subcutaneous tions are used for injecting most vaccines and certain antibiotics. tissue.

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5.4 Accessory Skin Structures external and internal parts (figure 5.6b). At the opening of the follicle, the external epithelial root sheath has all the strata found in thin skin. Deeper in the hair follicle, the number of cells decreases LEARNiNg OuTCOMES until at the hair bulb only the stratum basale is present. This has After reading this section, you should be able to important consequences for skin repair. If the epidermis and the superficial part of the dermis are damaged, the undamaged part of A. Describe the structure of a hair and discuss the phases the hair follicle that lies deep in the dermis can be a source of new of hair growth. epithelium. The internal epithelial root sheath has raised edges B. Explain the function of the arrector pili muscle. that mesh closely with the raised edges of the hair cuticle and hold C. Name the glands of the skin and describe the secretions the hair in place. When a hair is pulled out, the internal epithelial they produce. root sheath usually comes out as well and is plainly visible as whitish D. Describe the parts of a nail and explain how nails grow. tissue around the root of the hair. The hair bulb is an expanded knob at the base of the hair root The accessory skin structures include the hair, glands , and nails. (figure 5.6a,b). Inside the hair bulb is a mass of undifferentiated epithelial cells, the matrix, which produces the hair and the internal epithelial root sheath. The dermis of the skin projects into the hair Hair bulb as a hair papilla; it contains blood vessels that provide nourish- The presence of hair is one of the characteristics of all mammals; ment to the cells of the matrix. if the hair is dense and covers most of the body surface, it is called fur. In humans, hair is found everywhere on the skin except the palms, the soles, the lips, the nipples, parts of the external genitalia, and the distal segments of the fingers and toes. By the fifth or sixth month of fetal development, delicate, Clinical unpigmented hair called lanugo (lă-noo′gō) has developed and IMPaCT covered the fetus. Near the time of birth, terminal hairs, which are long, coarse, and pigmented, replace the lanugo of the scalp, eyelids, The integumentary System as a and eyebrows. Vellus (vel′ŭs) hairs, which are short, fine, and usually unpigmented, replace the lanugo on the rest of the body. At Diagnostic Aid puberty, terminal hair, especially in the pubic and axillary regions, he integumentary system can be used in diagnosis because it replaces much of the vellus hair. The hair of the chest, legs, and is easily observed and oft en refl ects events occurring in other arms is approximately 90% terminal hair in males and approxi- Tparts of the body. For example, cyanosis (sī-ă-nō′sis), a bluish mately 35% in females. In males, terminal hairs replace the vellus color to the skin that results from decreased blood oxygen content, hairs of the face to form the beard. The beard, pubic, and axillary is an indication of impaired cardiovascular or respiratory function. hair are signs of sexual maturity. In addition, pubic and axillary hair When red blood cells wear out, they are broken down, and the liver may function as wicks for dispersing odors produced by secretions excretes part of their contents as bile pigments into the small intestine. from specialized glands in the pubic and axillary regions. It also Jaundice (jawn′dis), a yellowish skin color, occurs when excess bile has been suggested that pubic hair protects against abrasion during pigments accumulate in the blood. If a disease, such as viral hepatitis, intercourse and axillary hair reduces friction when the arms move. damages the liver, bile pigments are not excreted and accumulate in the blood. Rashes and lesions in the skin can be symptomatic of problems Hair Structure elsewhere in the body. For example, scarlet fever results from a bacte- A hair is divided into the shaft, which protrudes above the surface rial infection in the throat. Th e bacteria release a toxin into the blood of the skin, and the root, located below the surface (figure 5.6a). that causes the pink-red rash for which this disease was named. In The base of the root is expanded to form the hair bulb. Most of the allergic reactions (see chapter 22), histamine released into the tissues root and the shaft are composed of columns of dead, keratinized produces swelling and reddening. Development of the skin rash called epithelial cells arranged in three concentric layers: the medulla, hives can indicate an allergy to foods or drugs, such as penicillin. Th e condition of the skin, hair, and nails is aﬀ ected by nutri- the cortex, and the cuticle (figure 5.6c). The medulla (me-dool′ă) tional status. Vitamin A defi ciency causes the skin to produce excess is the central axis of the hair; it consists of two or three layers of keratin and assume a characteristic sandpaper texture, whereas iron- cells containing soft keratin. The cortex forms the bulk of the hair; defi ciency anemia causes the nails to lose their normal contour and it consists of cells containing hard keratin. The cortex is covered by become fl at or concave (spoon-shaped). the cuticle (kū′ti-kl), a single layer of cells that contain hard keratin. Hair concentrates many substances, which can be detected by The edges of the cuticle cells overlap like shingles on a roof. laboratory analysis, and comparing a patient’s hair with “normal” The hair follicle is a tubelike invagination of the epidermis hair can be useful in certain diagnoses. For example, lead poisoning that extends into the dermis from which hair develops. A hair fol- results in high levels of lead in the hair. However, hair analysis as a licle consists of a dermal root sheath and an epithelial root sheath. screening test to determine a person’s general health or nutritional The dermal root sheath is the portion of the dermis that surrounds status is unreliable. the epithelial root sheath. The epithelial root sheath is divided into

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Hair shaft (above skin surface)

Medulla Cortex Hair root Hair (below skin Cuticle surface)

Arrector pili (smooth muscle)

Sebaceous gland

Dermal root sheath

External epithelial Hair root sheath Hair bulb follicle (base of Internal epithelial hair root) root sheath Matrix Artery Vein Hair papilla (a) Adipose tissue

Medulla Cortex Cuticle Dermal root sheath External epithelial root sheath Matrix Internal epithelial (growth zone) root sheath Melanocyte

Stratum basale Hair papilla Basement membrane (b) (c)

Hair

Hair follicle

Figure 5.6 Hair Follicle (a) The hair follicle contains the hair and consists of a dermal and an epithelial root sheath. (b) Enlargement of the hair follicle wall and hair bulb. (c) Cross section of a hair within a hair follicle.

Hair Growth losing a hair normally means that the hair is being replaced. The Hair is produced in cycles that involve a growth stage and a resting length of each stage depends on the hair—eyelashes grow for stage. During the growth stage, hair is formed by matrix cells that approximately 30 days and rest for 105 days, whereas scalp hairs differentiate, become keratinized, and die. The hair grows longer grow for 3 years and rest for 1–2 years. At any given time, an esti- as cells are added at the base of the hair root. Eventually, hair mated 90% of the scalp hairs are in the growing stage, and loss of growth stops; the hair follicle shortens and holds the hair in place. approximately 100 scalp hairs per day is normal. A resting period follows, after which a new cycle begins and a new The most common kind of permanent hair loss is “pattern hair replaces the old hair, which falls out of the hair follicle. Thus, baldness.” Hair follicles shrink and revert to producing vellus hair,

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Clinical IMPaCT Burns

burn is injury to a tissue caused by heat, cold, friction, chemicals, electricity, or Head 9% aradiation. Burns are classifi ed according to the extent of surface area involved and the depth of the burn. For an adult, the surface area that is burned can be conveniently estimated by “the rule of nines,” which divides the body into areas that are approximately 9%, or Upper limb 9% multiples of 9%, of the body surface area (BSA; fi gure 5B). For younger patients, surface area relationships are diﬀ erent. For example, in an infant, the head and neck are 21% of BSA, Trunk 18% (front or back) whereas in an adult they are 9%. For burn vic- Head 15% tims younger than age 15, a table specifi cally developed for them should be consulted. On the basis of depth, burns are classifi ed Upper limb 9% as either partial-thickness or full-thickness Genitalia 1% burns (fi gure 5C). Partial-thickness burns are Trunk 16% subdivided into fi rst- and second-degree burns. (front or back) First-degree burns involve only the epidermis and may result in redness, pain, and slight edema Lower limb 18% Genitalia 1% (swelling). Th ey can be caused by sunburn or brief exposure to hot or cold objects, and they heal in a week or so without scarring. Lower limb 17% Second-degree burns damage the epidermis and dermis. Minimal dermal damage causes (a) (b) redness, pain, edema, and blisters. Healing takes approximately 2 weeks, and no scarring FiguRE 5B The Rule of Nines results. However, if the burn goes deep into the (a) In an adult, surface areas can be estimated using the rule of nines: each major area of the body is dermis, the wound appears red, tan, or white; 9%, or a multiple of 9%, of the total body surface area. (b) In infants and children, the head represents may take several months to heal; and might a larger proportion of surface area, so the rule of nines is not as accurate, as can be seen in this depiction scar. In all second-degree burns, the epidermis of a 5-year-old child. regenerates from epithelial tissue in hair follicles and sweat glands, as well as from the edges Full-thickness burns are also called third- completely destroyed, and deeper tissue may of the wound. degree burns. Th e epidermis and dermis are be involved. Th ird-degree burns are oft en sur-

which is very short, transparent, and for practical purposes invisible. Hair Color Eventually, hair production in these smaller follicles may completely Melanocytes within the hair bulb matrix produce melanin and pass cease. Although baldness is more common and more pronounced it to keratinocytes in the hair cortex and medulla. As with the skin, in certain men, it can also occur in women. Genetic factors and the varying amounts and types of melanin cause different shades of hormone testosterone are involved in causing pattern baldness. hair color. Blonde hair has little black-brown melanin, whereas jet The average rate of hair growth is approximately 0.3 mm per day, black hair has the most. Intermediate amounts of melanin account although hairs grow at different rates, even in the same approximate for different shades of brown. Red hair is caused by varying amounts location. Cutting, shaving, or plucking hair does not alter the growth of a red type of melanin. Hair sometimes contains both black-brown rate or the character of the hair, but hair can feel coarse and bristly and red melanin. With age, the amount of melanin in hair can shortly after shaving because the short hairs are less flexible. decrease, causing hair color to fade or become white (i.e., no melanin). Maximum hair length is determined by the rate of hair growth and Gray hair is usually a mixture of unfaded, faded, and white hairs. the length of the growing phase. For example, scalp hair can become Hair color is controlled by several genes, and dark hair color is not very long, but eyelashes are short. necessarily dominant over light.

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rounded by fi rst- and second-degree burns. Although the areas that have fi rst- and second- Partial- Full- degree burns are painful, the region of third- thickness thickness degree burn is usually painless because the sensory receptors have been destroyed. Th ird- First- Second- Third- degree degree degree degree burns appear white, tan, brown, black, Epidermis or deep cherry-red. Skin can regenerate only from the edges, and skin graft s are oft en necessary. Th e depth and percentage of BSA aﬀ ected can be combined with other criteria to classify the seriousness of a burn. Th e following criteria defi ne amajor burn: a third-degree burn over 10% or more of the BSA; a second-degree burn over 25% or more of the BSA; or a second- Dermis or third-degree burn of the hands, feet, face, genitals, or anal region. Facial burns are oft en associated with damage to the respiratory tract, and burns of joints oft en heal with scar tissue formation that limits movement. A moderate Subcutaneous burn is a third-degree burn over 2–10% of the tissue BSA or a second-degree burn over 15–25% of the BSA. A minor burn is a third-degree burn over less than 2% or a second-degree burn over less than 15% of the BSA. FiguRE 5C Burns Deep partial-thickness and full-thickness Partial-thickness burns are subdivided into first-degree burns (damage to only the epidermis) and burns take a long time to heal, and they tend to second-degree burns (damage to the epidermis and part of the dermis). Full-thickness, or third-degree, form scar tissue with disfi guring and debilitat- burns destroy the epidermis, the dermis, and sometimes deeper tissues. ing wound contracture. To prevent these com- plications and speed healing, skin graft s are performed. In a split skin graft , the epidermis and they serve as a source of epithelial cells that tory because the body’s immune system recog- part of the dermis are removed from another form a new epidermis. Th is is the same process nizes the graft as a foreign substance and rejects part of the body and placed over the burn. Inter- of epidermis formation that occurs following it. A solution to this problem is laboratory-grown stitial fl uid from the burned area nourishes the superfi cial second-degree burns. skin. A piece of healthy skin from the burn victim graft until its dermis becomes vascularized. At When it is not possible or practical to move is removed and placed into a fl ask with nutrients the graft donation site, part of the dermis is still skin from one part of the body to a burn site, arti- and hormones that stimulate rapid growth. Th e present. Th e deep parts of hair follicles and fi cial skin or graft s from human cadavers or pigs skin that is produced consists only of epidermis sweat gland ducts remain in this dermis, where are used. Th ese techniques are oft en unsatisfac- and does not contain glands or hair.

Muscles ASSESS YOuR PROgRESS Associated with each hair follicle are smooth muscle cells called 14. When and where are lanugo, vellus, and terminal hairs found the arrector pili (ă-rek′tōr pī′lī), which extend from the dermal in the skin? root sheath of the hair follicle to the papillary layer of the dermis 15. What are the regions of a hair? What type of cells make up (figure 5.6a). Normally, the hair follicle and the hair inside it are most of a hair? at an oblique angle to the surface of the skin. When the arrector pili 16. Describe the three layers of a hair seen in cross section. muscles contract, however, they pull the follicle into a more per- 17. Describe the parts of a hair follicle. How is the epithelial root pendicular position, causing the hair to “stand on end.” Movement sheath important in skin repair? of the hair follicles produces raised areas called “goose bumps.” 18. In what part of a hair does growth take place? What are the stages of hair growth? Do all hairs grow at the same rate? 19. What determines the diff erent shades of hair color? 20. Explain the location and action of arrector pili muscles.

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Glands sweat pores (figure 5.7). Eccrine sweat glands can be divided into The major glands of the skin are the sebaceous glands and the two parts: the deep, coiled portion, which is located mostly in the sweat glands (figure 5.7). dermis, and the duct, which passes to the skin surface. The coiled part of the gland produces an isotonic fluid that is mostly water Sebaceous Glands but also contains some salts (mainly sodium chloride) and small amounts of ammonia, urea, uric acid, and lactic acid. As this fluid Sebaceous (sē-bā′shŭs) glands, located in the dermis, are simple or moves through the duct, sodium chloride moves by active trans- compound alveolar glands that produce sebum (sē′bŭm), an oily, port from the duct back into the body, thereby conserving salts. white substance rich in lipids. Because sebum is released by the The resulting hyposmotic fluid that leaves the duct is called lysis and death of secretory cells, sebaceous glands are classified as sweat. When the body temperature starts to rise above normal, the holocrine glands (see chapter 4). Most sebaceous glands are con- sweat glands produce sweat, which evaporates and cools the nected by a duct to the upper part of the hair follicles, from which body. Sweat also can be released in the palms, soles, and axillae as the sebum oils the hair and the skin surface. This prevents drying a result of emotional stress. Emotional sweating is used in lie and protects against some bacteria. A few sebaceous glands located detector (polygraph) tests because sweat gland activity may in the lips, the eyelids (meibomian glands), and the genitalia are increase when a person tells a lie. Such tests can detect the sweat not associated with hairs but open directly onto the skin surface. produced, even in small amounts, because the salt solution con- ducts electricity and lowers the electrical resistance of the skin. Sweat Glands Eccrine sweat glands are most numerous in the palms of There are two types of sweat, or sudoriferous (soo-dō-rif′er-ŭs) the hands and soles of the feet but are absent from the margin of the glands: eccrine glands and apocrine glands. At one time, physiologists lips, the labia minora, and the tips of the penis and clitoris. believed that secretions were released in a merocrine fashion from Apocrine (ap′ō-krin) sweat glands are simple, coiled, tubular eccrine glands and in an apocrine fashion from apocrine glands glands that usually open into hair follicles superficial to the opening (see chapter 4). But we now know that apocrine sweat glands also of the sebaceous glands (figure 5.7). Apocrine sweat glands are found release some of their secretions in a merocrine fashion, and possibly in the axillae and genitalia (scrotum and labia majora) and around some in a holocrine fashion. Traditionally, they are still referred to the anus. They do not help regulate temperature in humans. Apocrine as apocrine sweat glands. sweat glands become active at puberty as a result of sex hormones. Eccrine (ek′rin) sweat glands (sometimes called merocrine Their secretions contain organic substances, such as 3-methyl-2- [mer′ō-krin, mer′ō-krīn, mer′ō-krēn] sweat glands) are the most hexenoic acid, that are essentially odorless when first released but common type of sweat gland. They are simple, coiled, tubular are quickly metabolized by bacteria to cause what is commonly glands that open directly onto the surface of the skin through known as body odor. Many mammals use scent as a means of communication, and physiologists have suggested that the activity of apocrine sweat glands may signal sexual maturity.

Other Glands Other skin glands are the ceruminous glands and the mammary Sweat pores glands. The ceruminous (sĕ-roo′mi-nŭs) glands are modified eccrine sweat glands located in the ear canal (external auditory Duct of eccrine sweat gland canal). Cerumen, or earwax, is composed of the combined secretions of ceruminous glands and sebaceous glands. Cerumen and hairs in Duct of Arrector pili the ear canal protect the tympanic membrane by preventing the apocrine (smooth muscle) entry of dirt and small insects. However, an accumulation of ceru- sweat gland men can block the ear canal and make hearing more difficult. Hair follicle Sebaceous gland The mammary glands are modified apocrine sweat glands located in the breasts. They produce milk. The structure and regu- Eccrine lation of mammary glands are discussed in chapters 28 and 29. sweat gland Hair bulb Nails A nail is a thin plate consisting of layers of dead stratum corneum cells that contain a very hard type of keratin. Nails are located on Apocrine sweat gland the distal ends of the digits (fingers and toes). A nail consists of the proximal nail root and the distal nail body (figure 5.8a). The nail root is covered by skin, and the nail body is the visible portion Figure 5.7 Glands of the Skin of the nail. The lateral and proximal edges of the nail are covered Sebaceous glands and apocrine sweat glands empty into a hair follicle. by skin called the nail fold, and the edges are held in place by the Eccrine sweat glands empty onto the surface of the skin. nail groove (figure 5.8b). The stratum corneum of the nail fold

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Free edge Nail body Nail groove Nail fold Nail body Nail fold Nail groove Lunula Bone

Cuticle Epidermis (b) (a) Nail root

Cuticle Nail root Nail body (under the skin) Free edge Nail matrix Hyponychium Nail bed Bone

Epidermis

Figure 5.8 Nail (a) Dorsal view of the exterior nail. (b) Cross section of the nail. (c) Longitudinal section of the nail. (c)

grows onto the nail body as the cuticle, or eponychium (ep-ō- Assess YOUR PROGRESS nik′ē-ŭm). Beneath the free edge of the nail body is the hypo- 21. What do sebaceous glands secrete? What is the function of nychium (hī′pō-nik′ē-ŭm), a thickened region of the stratum the secretion? corneum (figure 5.8c). 22. Which glands of the skin are responsible for cooling the body? The nail root extends distally from the nail matrix. The nail Where are they located? Which glands are involved with also attaches to the underlying nail bed, which is located between producing body odor? Where are they located? the nail matrix and the hyponychium. The nail matrix and bed 23. Name the parts of a nail. Which part produces most of the nail? are composed of epithelial tissue, with a stratum basale that gives What is the lunula? rise to the cells that form the nail. The nail matrix is thicker than the nail bed and produces nearly all of the nail. The nail bed is 24. What makes a nail hard? Do nails have growth stages? visible through the clear nail and appears pink because of blood vessels in the dermis. A small part of the nail matrix, the lunula (loo′noo-lă), is seen through the nail body as a whitish, crescent- 5.5 Physiology of the shaped area at the base of the nail. The lunula, seen best on the Integumentary System thumb, appears white because the blood vessels do not show through the thicker nail matrix. LEARNING OUTCOMES As the nail forms in the nail matrix and bed, it slides over the nail bed toward the distal end of the digit. Nails grow at an average After reading this section, you should be able to rate of 0.5–1.2 mm per day, and fingernails grow more rapidly than A. Relate the protective functions of the skin, hair, glands, toenails. Unlike hair, they grow continuously throughout life and and nails. do not have a resting phase. B. Explain how the skin acts as a sense organ. C. Discuss the importance of the skin in temperature regulation. Predict 3 D. Describe the involvement of the skin in vitamin D While trying to fix some loose boards on his deck, Bob hit his left thumb production and in excretion. with his hammer. The hammer struck his thumbnail distal to the lunula and proximal to the hyponychium. After a short period, a dark area appeared in Protection the area of the nail bed. The injury was very painful until a physician drilled a small hole through Bob’s nail, releasing bloody fluid. After nearly 2 months, The integumentary system is the body’s fortress, defending it the dark area moved to the free edge of the nail. Explain why a dark area from harm: developed in the nail. What caused Bob’s pain, and why did drilling a hole 1. The skin protects underlying structures from mechanical in his nail relieve it? Why did the dark area move distally over time? damage. The dermis provides structural strength, preventing

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tearing of the skin. The stratified epithelium of the epidermis Contraction of the arrector pili muscles causes hair to stand protects against abrasion. As the outer cells of the stratum on end, but this does not significantly reduce heat loss in humans corneum slough off, they are replaced by cells from the stra- because so little hair covers the body. However, the hair on the head tum basale. Calluses develop in areas subject to heavy friction is an effective insulator. We consider general temperature regulation or pressure. further in chapter 25. 2. The skin prevents microorganisms and other foreign substances from entering the body. Secretions from skin glands produce an environment unsuitable for some microorganisms. The Vitamin D Production skin also contains components of the immune system that act Vitamin D functions as a hormone to stimulate the uptake of cal- against microorganisms (see chapter 22). cium and phosphate from the intestines, to promote their release 3. Melanin absorbs ultraviolet light and protects underlying from bones, and to reduce calcium loss from the kidneys, resulting structures from its damaging effects. in increased blood calcium and phosphate levels. Adequate levels 4. Hair provides protection in several ways. The hair on the of these minerals are necessary for normal bone metabolism (see head acts as a heat insulator and protects against ultraviolet chapter 6), and calcium is required for normal nerve and muscle light and abrasion. The eyebrows keep sweat out of the eyes, function (see chapter 9). the eyelashes protect the eyes from foreign objects, and hair in the nose and ears prevents dust and other materials from entering. Axillary and pubic hair are a sign of sexual maturity and protect against abrasion. 5. Nails protect the ends of the fingers and toes from damage and Case can be used in defense. Frostbite 6. The intact skin plays an important role in reducing water loss STUDY because its lipids act as a barrier to the diffusion of water. illy was hiking in the mountains one autumn day. Unexpect- Some lipid-soluble substances readily pass through the epi- edly, a cold front moved in and the temperature dropped to dermis. Lipid-soluble medications can be administered by applying bwell below freezing. Billy was unprepared for the temperature them to the skin, after which the medication slowly diffuses change, and he did not have a hat or earmuffs. As the temperature through the skin into the blood. For example, nicotine patches are dropped, his ears and nose became pale in color. After continued applied to help reduce withdrawal symptoms in people attempting exposure to the dropping temperatures, every 15–20 minutes, his to quit smoking. ears and nose turned red for 5–10 minutes and then became pale again. After several hours, Billy managed to hike back to the trail head. By then, he was very chilled and had no sensation in his ears Sensation or nose. As he looked in the rearview mirror of his car, he could see Receptors in the skin can detect pain, heat, cold, and pressure. For that the skin of his ears and nose had turned white. It took Billy example, the epidermis and dermal papillae are well supplied with 2 hours to drive to the nearest emergency room, where he learned touch receptors. The dermis and deeper tissues contain pain, heat, that the white skin meant he had frostbite of his ears and nose. About 2 weeks later, the frostbitten skin peeled. Despite treatment cold, touch, and pressure receptors. Hair follicles (but not the hair) with an antibiotic, the skin of his right ear became infected. Eventually, are well innervated, and sensory receptors surrounding the base Billy recovered, but he lost part of his right ear. of hair follicles can detect hair movement. Sensory receptors are discussed in more detail in chapter 14. Predict 4 Frostbite is the most common type of freezing injury. When skin Temperature Regulation temperature drops below 0°C (32°F), the skin freezes and ice crystal Body temperature is affected by blood flow through the skin. When formation damages tissues. blood vessels (arterioles) in the dermis dilate, more warm blood a. Using figure 5.9, describe the mechanism that caused billy’s ears flows from deeper structures to the skin, and heat loss increases and nose to become pale. How is this mechanism beneficial (figure 5.9, steps 1 and 2). Body temperature tends to increase as a when the ambient temperature is decreasing? result of exercise, fever, or a rise in environmental temperature. In b. explain what happened when billy’s ears and nose periodically order to maintain homeostasis, this excess heat must be lost. The turned red. How is this beneficial when the ambient temperature body accomplishes this by producing sweat. The sweat spreads over is very cold? the surface of the skin; as it evaporates, the body loses heat. c. What is the significance of billy’s ears and nose turning and When blood vessels in the dermis constrict, less warm blood staying white? flows from deeper structures to the skin, and heat loss decreases d. Why is a person with frostbite likely to develop an infection of (figure 5.9, steps 3 and 4). If body temperature begins to drop the affected part of the body? below normal, heat can be conserved by a decrease in the diameter of dermal blood vessels.

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Blood vessel 1 Blood vessel dilation results in dilates increased blood flow toward the 1 (vasodilation). surface of the skin.

2 Heat loss across the epidermis increases. 2 Increased blood flow beneath the epidermis results in increased heat loss (gold arrows). Epidermis

(a)

Blood vessel constricts 3 Blood vessel constriction 3 (vasoconstriction). results in decreased blood flow toward the surface of the skin.

4 Heat loss across the epidermis decreases.

4 Decreased blood flow beneath the epidermis results in decreased heat loss. Epidermis PROCESS FiguRE 5.9 Heat Exchange (b) in the Skin

Vitamin D synthesis begins in skin exposed to ultraviolet light, Excretion and people can produce all the vitamin D they require by this process Excretion is the removal of waste products from the body. In addition if enough ultraviolet light is available. However, because people to water and salts, sweat contains a small amount of waste products, live indoors and wear clothing, their exposure to ultraviolet light including urea, uric acid, and ammonia. However, even when large may not be adequate for the manufacture of sufficient vitamin D. amounts of sweat are lost, the quantity of waste products eliminated This is especially likely for people living in cold climates because in the sweat is insignificant because the urinary system excretes most they remain indoors or are covered by warm clothing when out- of the body’s waste products. doors. Fortunately, vitamin D can also be ingested and absorbed in the small intestine. Natural sources of vitamin D are liver (especially ASSESS YOuR PROgRESS fish liver), egg yolks, and dairy products (e.g., butter, cheese, and milk). In addition, the diet can be supplemented with vitamin D in 25. In what ways does the skin provide protection? fortified milk or vitamin pills. 26. What kinds of sensory receptors are in the skin, and why are Vitamin D synthesis begins when the precursor molecule they important? 7-dehydrocholesterol (7-dē-hī′drō-kō-les′ter-ol) is exposed to ultra- 27. How does the skin help regulate body temperature? violet light and converted into cholecalciferol (kō′lē-kal-sif′er-ol). 28. Name the locations where cholecalciferol is produced and then Cholecalciferol is released into the blood and modified by hydrox- modifi ed into vitamin D. What are the functions of vitamin D? ylation (hydroxide ions are added) in the liver and kidneys to form 29. What substances are excreted in sweat? Is the skin an important active vitamin D, calcitriol (kal-si-trī′ol). site of excretion?

155

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Systems PaTHOlOGY Burns

Background information When large areas of skin are severely burned, the resulting systemic effects can be life-threatening. Within minutes of a major burn injury, there is increased permeability of the capillaries, which are the small blood vessels in which fluid, gases, nutrients, and waste products are normally exchanged between the blood and the tissues. This increased permea- Name: Sam bility occurs at the burn site and throughout the body. As a result, Gender: Male fluid and electrolytes (see chapter 2) are lost from the burn wound and Age: 23 into tissue spaces. The loss of fluid decreases blood volume, which decreases the heart’s ability to pump blood. The resulting decrease in Comments blood delivery to tissues can cause tissue damage, shock, and even Sam fell asleep while death. Treatment consists of administering intravenous fluid at a smoking after ingesting faster rate than it leaks out of the capillaries. Although this fluid sleeping pills. He replacement can reverse the shock and prevent death, fluid continues received partial-thickness to leak into tissue spaces, causing pronounced edema (swelling). and full-thickness burns Typically, after 24 hours, capillary permeability returns to normal, and the amount of intravenous fluid administered can be greatly decreased. How burns cause capillary permeability to (fi gure 5D) and was admitted to the emergency change is not well understood; however, it is clear that, following room and later transferred to the burn unit a burn, immunological and metabolic changes affect not only in critical condition, suff ering from shock. capillaries but the rest of the body as well. For example, chemi- large volumes of intravenous fl uids were cal mediators (see chapter 4), which are released in response to administered and Sam’s condition improved. tissue damage, contribute to changes in capillary permeability He was given a high-protein, high-caloric diet, throughout the body. as well as topical antimicrobial drugs to treat Substances released from the burn may also cause cells to infection of his wounds the fi rst few weeks of function abnormally. Burn injuries result in an almost imme- treatment. Sam developed venous thrombosis diate hypermetabolic state, which persists until wound closure. in his left leg, which required additional Two other factors contributing to the increased metabolism treatment. later, his physician recommended are (1) a resetting of the temperature control center in the brain to a higher temperature and (2) hormones released by debridement of his wounds. the endocrine system (e.g., epinephrine and norepinephrine from the adrenal glands, which can increase cell metabolism).

Full-thickness burn

Partial-thickness burn

Figure 5D Partial- and Full-thickness Burns

Figure 5E Patient in a Burn unit

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MUSCULAR Hypermetabolic state may lead to loss in muscle mass. SKELETAL NERVOUS Increased red blood cell Pain in partial-thickness burns; body production in red temperature increases as control center bone marrow. in brain is reset; abnormal K+ levels disrupt normal nervous system activity. Burns

DIGESTIVE Symptoms • Tissue damage of Tissue damage to intestinal lining LYMPHATIC AND IMMUNE and liver as a result of decreased skin and possibly blood fl ow; bacteria of intestines deeper tissue Infl ammation; depression of immune may cause systematic infection; • edema system may lead to infection. liver releases blood-clotting • Shock factors in response to injury. • Microbial infection Treatment • Intravenous fl uids CARDIOVASCULAR • High-protein, Decreased blood volume, edema, and URINARY high-calorie diet shock may occur due to increased capillary Urine production decreases • antimicrobials permeability; abnormal ion levels disrupt in response to low blood normal heart rate; increased blood clotting volume; tissue damage to • Debridement may cause venous thrombosis; preferential kidneys due to low blood fl ow. • Skin grafts blood fl ow promotes healing.

RESPIRATORY edema may obstruct airways; ENDOCRINE increased respiratory rate in Release of epinephrine and norepinephrine response to hypermetabolic state. from the adrenal glands in response to injury contributes to hypermetabolic state and increased body temperature.

Compared with a normal body temperature of approximately 37°C (98.6°F), or second week after the injury contributes to the high infection rate. First, a typical burn patient may have a body temperature of 38.5°C (101.3°F) the thermally altered tissue is recognized as a foreign substance, which despite the higher loss of water by evaporation from the burn. stimulates the immune system. Then, the immune system is overwhelmed In severe burns, the increased metabolic rate can result in a loss of as immune system cells become less effective and production of the chemi- as much as 30–40% of the patient’s preburn weight. To help compensate, cals that normally provide resistance to infections decreases (see chapter 22). treatment may include doubling or tripling the patient’s caloric intake. In The greater the magnitude of the burn, the greater the depression of the addition, the need for protein, which is necessary for tissue repair, is greater. immune system and the greater the risk for infection. Normal skin maintains homeostasis by preventing microorganisms Venous thrombosis, the development of a clot in a vein, is another from entering the body. Because burns damage and sometimes com- complication of burns. Blood normally forms a clot when exposed to dam- pletely destroy the skin, microorganisms can cause infections. For this aged tissue, such as at a burn site, but clotting can also occur elsewhere, such reason, burn patients are maintained in an aseptic (sterile) environment as in veins, where clots can block blood flow, resulting in tissue destruction. in an attempt to prevent the entry of microorganisms into the wound. The concentration of chemicals that cause clotting (called clotting factors) They are also given antimicrobial drugs, which kill microorganisms or increases for two reasons: Loss of fluid from the burn patient concentrates suppress their growth. Debridement (dā-brēd-mont′), the removal of the chemicals, and the liver releases an increased amount of clotting factors. dead tissue from the burn (figure 5E), helps prevent infections by cleaning the wound and removing tissue in which infections could develop. Skin Predict 5 grafts, performed within a week of the injury, also help close the wound When Sam was first admitted to the burn unit, the nurses carefully and prevent the entry of microorganisms. monitored his urine output. Why does that make sense in light Despite these efforts, however, infections are still the major cause of of his injuries? death for burn victims. Depression of the immune system during the first

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5.6 Effects of Aging on the Skin that is exposed to sunlight appears to age more rapidly than nonexposed skin. This effect is observed on areas of the body that Integumentary System receive sun exposure, such as the face and hands (figure 5.10). However, the effects of chronic sun exposure on the skin are different from the effects of normal aging. In skin exposed to sunlight, LEARNING OUTCOME normal elastic fibers are replaced by an interwoven mat of thick, After reading this section, you should be able to elastic-like material, the number of collagen fibers decreases, and A. List the changes the integumentary system undergoes the ability of keratinocytes to divide is impaired. with age. Assess YOUR PROGRESS As the body ages, the skin is more easily damaged because the epidermis thins and the amount of collagen in the dermis decreases. 30. Compared with young skin, why is aged skin more likely to be Skin infections are more likely, and skin repair occurs more damaged, wrinkled, and dry? slowly. A decrease in the number of elastic fibers in the dermis and 31. Why is heat potentially dangerous to the elderly? a loss of adipose tissue from the subcutaneous tissue cause the skin 32. Explain what causes age spots and white hair. to sag and wrinkle. 33. What effect does exposure to sunlight have on skin? Retin-A (tretinoin; tret′i-nō-in) is a vitamin A derivative that appears to be effective in treating fine wrinkles on the face, such as those caused by long-term exposure to the sun; it is not effective in treating deep lines. One ironic side effect of Retin-A use is increased sensitivity to the sun’s ultraviolet rays. Doctors prescribing this cream caution their patients to always use a sunblock when they are going to be outdoors. The skin also becomes drier with age as sebaceous gland activity decreases. Decreases in the activity of sweat glands and the blood supply to the dermis result in a reduced ability to regulate body temperature. Elderly individuals who do not take proper precautions may experience heat exhaustion, which can even lead to death. The number of functioning melanocytes generally decreases; however, in some localized areas, especially on the hands and face, (a) (b) melanocytes increase in number, producing age spots. (Age spots are different from freckles, which are caused by an increase in Figure 5.10 Effects of Sunlight on Skin melanin production, not an increase in melanocyte numbers.) (a) A 91-year-old Japanese monk who has spent most of his life indoors. White or gray hairs also appear because of a decrease in or lack of (b) A 62-year-old Native American woman who has spent most of her melanin production. life outdoors.

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Diseases and Disorders Table 5.2 Skin

Condition Description Birthmarks Congenital (present at birth) disorders of the dermal capillaries Ringworm Fungal infection that produces patchy scaling and inflammatory response in the skin Eczema and dermatitis Inflammatory conditions of the skin caused by allergy, infection, poor circulation, or exposure to chemical or environmental factors Psoriasis Chronic skin disease characterized by thicker than normal epidermal layer (stratum corneum) that sloughs to produce large, silvery scales; bleeding may occur if the scales are scraped away Vitiligo Development of patches of white skin where melanocytes are destroyed, apparently by an autoimmune response Bacterial Infections Impetigo Small blisters containing pus; easily rupture to form a thick, yellowish crust; usually affects children Erysipelas Swollen patches in the skin caused by the bacterium Streptococcus pyogenes Decubitus ulcers (bedsores, Develop in people who are bedridden or confined to a wheelchair; compression of tissue and reduced circulation result in pressure sores) destruction of the skin and subcutaneous tissue, which later become infected by bacteria, forming ulcers Acne Disorder of sebaceous glands and hair follicles that occurs when sloughed cells block the hair follicle, resulting in the formation of a lesion or pimple; the lesion may become infected and result in scarring; acne appears to be affected by hormones, sebum, abnormal keratinization within hair follicles, and the bacterium Propionibacterium acnes Viral Infections Rubeola (measles) Skin lesions; caused by a virus contracted through the respiratory tract; may develop into pneumonia or infect the brain, causing damage Rubella (German measles) Skin lesions; usually mild viral disease contracted through the respiratory tract; may be dangerous if contracted during pregnancy because the virus can cross the placenta and damage the fetus Chickenpox Skin lesions; usually mild viral disease contracted through the respiratory tract Shingles Painful skin lesions; caused by the chickenpox virus after childhood infection; can recur when the dormant virus is activated by trauma, stress, or another illness Cold sores (fever blisters) Skin lesions; caused by herpes simplex I virus; transmitted by oral or respiratory routes; lesions recur Genital herpes Genital lesions; caused by herpes simplex II virus; transmitted by sexual contact

Go to www.mhhe.com/seeley10 for additional information on these pathologies.

Answer Learn to Predict From page 139

To begin, we must identify the important information provided in We also learned in this chapter that the epidermis is a stratified the question. First, we are told that Laura is spending her summer squamous epithelium (as described in chapter 4) composed of many at the pool, constantly exposed to the sun, and develops a “golden layers of cells. Mitosis of cells in the deepest layer (stratum basale) of tan.” Second, she returns to school in the fall, thus spending less time the epidermis produces new cells, which gradually undergo kerati- outside, and her tan fades. nization and eventually die. At the surface of the skin, keratinized We know that sun exposure leads to tanning of the skin, but to (dead) keratinocytes are sloughed off and replaced by new ones daily. answer this question fully we must consider what specifically causes So why did Laura’s tan fade? It faded because the older, heavily the skin to darken and why tanning is not permanent. We learned in pigmented keratinocytes were sloughed off each day and replaced chapter 5 that melanocytes in the epidermis produce melanin in re- with new cells. These new cells, produced after she returned to sponse to sun exposure and package it in melanosomes. Keratinocytes school, were less pigmented and her skin became a lighter color. phagocytize the tips of melanocyte processes containing the melanosomes, and the result is pigmented keratinocytes, and thus darker skin. We can therefore conclude that Laura’s skin is darker due to increased Answers to the rest of this chapter’s Predict questions are in Appendix G. sun exposure and increased melanin production during the summer.

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The integumentary system consists of the skin, hair, glands, and nails. Summary 5.1 Functions of the Integumentary System 5.3 Subcutaneous Tissue (p. 146) (p. 140) 1. Located beneath the dermis, the subcutaneous tissue is loose connective tissue that contains collagen and elastic fibers. The integumentary system separates and protects us from the external 2. The subcutaneous tissue attaches the skin to underlying structures and environment. Other functions include sensation, temperature regulation, is a site of lipid storage. vitamin D production, and excretion of small amounts of waste products. 5.4 Accessory Skin Structures (p. 148) 5.2 Skin (p. 140) Hair Epidermis 1. Lanugo (fetal hair) is replaced near the time of birth by terminal hairs 1. The epidermis is stratified squamous epithelium divided into five strata. (scalp, eyelids, and eyebrows) and vellus hairs. At puberty, vellus hairs 2. The stratum basale consists of keratinocytes, which produce the cells can be replaced with terminal hairs. of the more superficial strata. 2. A hair has three parts: shaft, root, and hair bulb. 3. The stratum spinosum consists of several layers of cells held together 3. The root and shaft of a hair are composed of dead keratinized epithelial by many desmosomes. cells. In the center, a cortex of cells containing hard keratin surrounds 4. The stratum granulosum consists of cells filled with granules of kerato- a medulla composed of cells containing soft keratin. The cortex is hyalin. Cell death occurs in this stratum. covered by the cuticle, a single layer of cells filled with hard keratin. 5. The stratum lucidum consists of a layer of dead, transparent cells. 4. The hair bulb produces the hair in cycles, with a growth stage and a 6. The stratum corneum consists of many layers of dead squamous cells. resting stage. The most superficial cells slough off. 5. Hair color is determined by the amount and kind of melanin present. 7. Keratinization is the transformation of the living cells of the stratum 6. Contraction of the arrector pili muscles, which are smooth muscles, basale into the dead squamous cells of the stratum corneum. causes hair to “stand on end” and produces “goose bumps.” ■ Keratinized cells are filled with keratin and have a protein envelope, Glands both of which contribute to structural strength. The cells are also held together by many desmosomes. 1. Sebaceous glands produce sebum, which oils the hair and the surface ■ Intercellular spaces are filled with lipids from the lamellae that help of the skin. make the epidermis impermeable to water. 2. Eccrine sweat glands produce sweat, which cools the body. Apocrine sweat glands produce an organic secretion that can be broken down 8. Soft keratin is present in skin and the inside of hairs, whereas hard by bacteria to cause body odor. keratin occurs in nails and the outside of hairs. Hard keratin makes cells 3. Other skin glands are ceruminous glands, which make cerumen (ear- more durable, and these cells are not shed. wax), and mammary glands, which produce milk. Thick and Thin Skin Nails 1. Thick skin has all five epithelial strata. 1. The nail root is covered by skin, and the nail body is the visible part 2. Thin skin contains fewer cell layers per stratum, and the stratum of the nail. lucidum is usually absent. Hair is found only in thin skin. 2. Nearly all of the nail is formed by the nail matrix, but the nail bed contributes. Skin Color 3. The lunula is the part of the nail matrix visible through the nail body. 1. Melanocytes produce melanin inside melanosomes and then transfer 4. The nail is stratum corneum containing hard keratin. the melanin to keratinocytes. The size and distribution of melanosomes determine skin color. Melanin production is determined genetically 5.5 Physiology of the Integumentary System but can be influenced by ultraviolet light (tanning) and hormones. (p. 153) 2. Carotene, an ingested plant pigment, can cause the skin to appear yellowish. Protection 3. Increased blood flow produces a red skin color, whereas decreased blood 1. The skin protects against abrasion and ultraviolet light, prevents the flow causes pale skin. Decreased oxygen content in the blood results entry of microorganisms, helps regulate body temperature, and pre- in a bluish color, a condition called cyanosis. vents water loss. 2. Hair protects against abrasion and ultraviolet light and is a heat Dermis insulator. 1. The dermis is connective tissue divided into two layers. 3. Nails protect the ends of the digits. 2. The papillary layer has projections called dermal papillae and is composed of loose connective tissue that is well supplied with capillaries. Sensation 3. The reticular layer is the main layer. It is dense irregular connective The skin contains sensory receptors for pain, touch, hot, cold, and pressure, tissue consisting mostly of collagen. which allow for proper responses to the environment.

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Temperature Regulation Excretion 1. Through dilation and constriction of blood vessels, the skin controls Skin glands remove small amounts of waste products (e.g., urea, uric acid, heat loss from the body. and ammonia) but are not important in excretion. 2. Sweat glands produce sweat, which evaporates and lowers body temperature. 5.6 Effects of Aging on the Integumentary Vitamin D Production System (p. 158) 1. Skin exposed to ultraviolet light produces cholecalciferol, which is 1. As the body ages, blood flow to the skin declines, the skin becomes modified in the liver and then in the kidneys to form active vitamin D. thinner, and elasticity is lost. 2. Vitamin D increases blood calcium levels by promoting calcium uptake 2. Sebaceous and sweat glands become less active, and the number of from the small intestine, calcium release from bone, and the reduction melanocytes decreases. of calcium loss from the kidneys.

Review and Comprehension

1. If a splinter penetrates the skin of the palm of the hand to the second 12. After birth, the type of hair on the scalp, eyelids, and eyebrows is epidermal layer from the surface, the last layer damaged is the a. lanugo. c. vellus hair. a. stratum granulosum. d. stratum lucidum. b. terminal hair. b. stratum basale. e. stratum spinosum. 13. Hair c. stratum corneum. a. is produced by the dermal root sheath. For questions 2–6, match the layer of the epidermis with the correct b. consists of living, keratinized epithelial cells. description or function: c. is colored by melanin. a. stratum basale d. stratum lucidum d. contains mostly soft keratin. b. stratum corneum e. stratum spinosum e. grows from the tip. c. stratum granulosum 14. Given these parts of a hair and hair follicle: 2. Production of keratin fibers; formation of lamellar bodies; limited (1) cortex amount of cell division (2) cuticle 3. Sloughing occurs; 25 or more layers of dead squamous cells (3) dermal root sheath (4) epithelial root sheath 4. Production of cells; melanocytes produce and contribute melanin; (5) medulla hemidesmosomes present 5. Production of keratohyalin granules; lamellar bodies release lipids; Arrange the structures in the correct order from the outside of the hair cells die follicle to the center of the hair. a. 1,4,3,5,2 d. 4,3,1,2,5 6. Dispersion of keratohyalin around keratin fibers; layer appears trans- b. 2,1,5,3,4 e. 5,4,3,2,1 parent; cells dead c. 3,4,2,1,5 7. The function of melanin in the skin is to a. lubricate the skin. 15. Concerning hair growth, b. prevent skin infections. a. hair falls out of the hair follicle at the end of the growth stage. c. protect the skin from ultraviolet light. b. most of the hair on the body grows continuously. d. reduce water loss. c. cutting or plucking the hair increases its growth rate and thickness. e. help regulate body temperature. d. genetic factors and the hormone testosterone are involved in “pattern baldness.” 8. Concerning skin color, which pair of statements is not correctly matched? e. eyebrows have a longer growth stage and resting stage than a. skin appears yellow—carotene present scalp hair. b. no skin pigmentation (albinism)—genetic disorder c. skin tans—increased melanin production 16. Smooth muscles that produce “goose bumps” when they contract and d. skin appears blue (cyanosis)—oxygenated blood are attached to hair follicles are called e. African-Americans darker than Caucasians—more melanin in a. external root sheaths. African-American skin b. arrector pili. c. dermal papillae. For questions 9–11, match the layer of the dermis with the correct description d. internal root sheaths. or function: e. hair bulbs. a. papillary layer b. reticular layer For questions 17–19, match the type of gland with the correct description 9. Layer of dermis responsible for most of the structural strength of or function: the skin a. apocrine sweat gland 10. Layer of dermis responsible for fingerprints and footprints b. eccrine sweat gland 11. Layer of dermis responsible for cleavage lines and stretch marks c. sebaceous gland

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17. Alveolar glands that produce a white, oily substance; usually open into 22. The skin helps maintain optimum calcium and phosphate levels in hair follicles the body by participating in the production of 18. Coiled, tubular glands that secrete a hyposmotic fluid that cools the a. vitamin A. c. vitamin D. e. keratin. body; most numerous in the palms of the hands and soles of the feet b. vitamin B. d. melanin. 19. Secretions from these coiled, tubular glands are broken down by bac- 23. Which of these processes increase(s) heat loss from the body? teria to produce body odor; found in the axillae, in the genitalia, and a. dilation of dermal arterioles around the anus b. constriction of dermal arterioles c. increased sweating 20. The lunula of the nail appears white because d. Both a and c are correct. a. it lacks melanin. e. Both b and c are correct. b. blood vessels cannot be seen through the thick nail matrix. c. the cuticle decreases blood flow to the area. 24. In third-degree (full-thickness) burns, both the epidermis and the dermis d. the nail root is much thicker than the nail body. are destroyed. Which of the following conditions does not occur as a e. the hyponychium is thicker than the cuticle. result of a third-degree burn? a. dehydration (increased water loss) 21. Most of the nail is produced by the b. increased likelihood of infection a. cuticle. d. nail matrix. c. increased sweating b. hyponychium. e. dermis. d. loss of sensation in the burned area c. nail bed. e. poor temperature regulation in the burned area Answers in Appendix E

Critical Thinking

1. The skin of infants is more easily penetrated and injured by abrasion 6. Why are your eyelashes not a foot long? Your fingernails? than is the skin of adults. Based on this fact, which stratum of the 7. Pulling on hair can be quite painful, yet cutting hair is not painful. epidermis is probably much thinner in infants than in adults? Explain. 2. Melanocytes are found primarily in the stratum basale of the epidermis. 8. A patient has an ingrown toenail, in which the nail grows into the nail In reference to their function, why does this location make sense? fold. Would cutting the nail away from the nail fold permanently correct 3. The rate of water loss from the skin of a hand was measured. Following this condition? Why or why not? the measurement, the hand was soaked in alcohol for 15 minutes. After 9. Defend or refute the following statement: Dark-skinned children are all the alcohol had been removed from the hand, the rate of water more susceptible to rickets (insufficient calcium in the bones) than loss was again measured. Compared with the rate of water loss before fair-skinned children. soaking, what difference, if any, would you expect in the rate of water loss after soaking the hand in alcohol? 10. Harry, age 55, went to a health fair and had a PSA test. The test results and subsequent examinations indicated prostate cancer. Harry was 4. It has been several weeks since Goodboy Player has competed in a given radiation treatments and chemotherapeutic drugs. These drugs tennis match. After a match, he discovers that a blister has formed adversely affect cancer cells by interrupting mitosis, but they also inter- beneath an old callus on his foot, and the callus has fallen off. When rupt mitosis in normal cells. Describe the probable effect of chemo- he examines the callus, it appears yellow. Can you explain why? therapy on Harry’s epidermis, hair, nails, skin pigmentation, and 5. A woman has stretch marks on her abdomen, yet she states that she has sebaceous glands. never been pregnant. Is this possible? Answers in Appendix F

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anatomy & physiology

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