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WO 2016/044805 Al 24 March 2016 (24.03.2016) P O P C T

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WO 2016/044805 Al 24 March 2016 (24.03.2016) P O P C T (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2016/044805 Al 24 March 2016 (24.03.2016) P O P C T (51) International Patent Classification: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, A61K 9/107 (2006.01) A61K 31/00 (2006.01) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, A61K 9/48 (2006.01) A23L 1/29 (2006.01) KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (21) International Application Number: PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, PCT/US20 15/05 1083 SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (22) International Filing Date: TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 18 September 2015 (18.09.201 5) (84) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (26) Publication Language: English TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (30) Priority Data: TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, 62/052,435 18 September 2014 (18.09.2014) US DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, 62/052,450 18 September 2014 (18.09.2014) US LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (71) Applicant: VIRUN, INC. [US/US]; 2 1118 Commerce GW, KM, ML, MR, NE, SN, TD, TG). Pointe Drive, Walnut, CA 91789 (US). Declarations under Rule 4.17 : (72) Inventor: BROMLEY, Philip, J.; 520 East Wilshire Av — as to applicant's entitlement to apply for and be granted a enue, Fullerton, CA 92832 (US). patent (Rule 4.1 7(H)) (74) Agents: SEIDMAN, Stephanie, L. et al; DENTONS US — as to the applicant's entitlement to claim the priority of the LLP, 4435 Eastgate Mall, Suite 400, San Diego, CA 92121 earlier application (Rule 4.1 7(in)) (US). Published: (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, — with international search report (Art. 21(3)) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, © 00 © v © (54) Title: SOFT GEL COMPOSITIONS AND PRE-GEL CONCENTRATES (57) Abstract: Provided are compositions and methods for producing non-aqueous capsule compositions that contain additives such as essential fatty acids, including omega-3 fatty acids, omega-6 fatty acids, conjugated fatty acids, and other fatty acids; phytochem - icals, including phytosterols; other oils; and coenzymes, including coenzyme Q10, and other oil-based additives. SOFT GEL COMPOSITIONS AND PRE-GEL CONCENTRATES RELATEDAPPLICATIONS Benefit of priority is claimed to U.S. Provisional Application Serial No. 62/052,435, filed September , 2014, entitled "SOFT GEL COMPOSITIONS AND PRE-GEL CONCENTRATES," to Philip J. Bromley, and to U.S . Provisional Application Serial No. 62/052,450, filed September , 2014, entitled "FORMULATIONS OF WATER-SOLUBLE DERIVATIVES OF VITAMIN E AND SOFT GEL COMPOSITIONS, CONCENTRATES AND POWDERS CONTAINING SAME," to Philip J. Bromley. Where permitted, the subject matter of this application is incorporated by reference i its entirety. This application is related to International PCT Application No. PCT/US1 5/5 1097, filed the same day herewith, entitled "PRE-SPRAY EMULSIONS AND POWDERS CONTAINING NON-POLAR COMPOUNDS," to Philip J. Bromley, which claims priority to U.S. Provisional Application Serial No. 62/052,433, filed September 2014, entitled "PRE-SPRAY EMULSIONS AND POWDERS CONTAINING NON-POLAR COMPOUNDS," to Philip J. Bromley and to U.S. Provisional Application Serial No. 62/052,450, filed September , 2014, entitled "FORMULATIONS OF WATER-SOLUBLE DERIVATIVES OF VITAMIN E AND SOFT GEL COMPOSITIONS, CONCENTRATES AND POWDERS CONTAINING SAME," to Philip J. Bromley. This application also is related to U.S. Patent Application Serial No, 14/207,310, filed March 12, 2014, published as US-20 14-027 1593-A1, entitled "FORMULATIONS OF WATER-SOLUBLE DERIVATIVES OF VITAMIN E AND COMPOSITIONS CONTAINING SAME," which claims priority to U.S. Provisional Application Serial No. 61/852,243, filed March 15, 2013, entitled "FORMULATIONS OF PEG DERIVATIVES OF VITAMIN E AND COMPOSITIONS CONTAINING SAME," to Philip Bromley, and International PCT Application No. PCT/US20 14/25006, filed March 12, 2014, published as WO 2 14/1 5 09, entitled "FORMULATIONS OF WATER-SOLUBLE DERIVATIVES OF VITAMIN E AND COMPOSITIONS CONTAINING SAME," which a so claims priority to U.S. Provisional Application Serial No. 61/852,243, filed March 15, 2013, entitled "FORMULATIONS OF PEG DERIVATIVES OF VITAMIN E AND COMPOSITIONS CONTAINING SAME" and to U.S. Provisional Application Serial No. 61/863,732, filed August 8, 2013, entitled "FORMULATIONS OF WATER- SOLUBLE DERIVATIVESOF VITAMIN E AND COMPOSITIONS CONTAINING SAME," each to Philip Bromley. This application is related to U.S. Patent Application Serial No. 13/815,193, filed February 8, 2013, published as US-2013-0309362-A1, entitled "BEVERAGE COMPOSITIONS CONTAINING NON-POLAR COMPOUNDS," to Philip J. Bromley, and to International PCT Application No. PCT/US 13/25445, filed February 8, 2013, published as International Publication No. WO 2013/120025, entitled "BEVERAGE COMPOSITIONS CONTAINING NON-POLAR COMPOUNDS," to Philip J. Bromley, both of which claim priority to U.S. Provisional Application Serial No. 61/633,431, filed February 10, 2012, entitled "BEVERAGE COMPOSITIONS CONTAINING NON-POLAR COMPOUNDS," and U.S. Provisional Application Serial No. 61/743,466, filed September 4, 2012, entitled "BEVERAGE COMPOSITIONS CONTAINING NON-POLAR COMPOUNDS," each to Philip J. Bromley. This application is related to U.S. Patent Application Serial No. 12/383,244, filed March 20, 2009, published as US-2009-0297665-A1, issued as U.S. Patent No. 8,282,977, entitled "COMPOSITIONS CONTAINING NON-POLAR COMPOUNDS," and International PCT Application No. PCT/US2009/001775, filed March 20, 2009, published as International Publication No. WO 2009/117152, entitled "EMULSIONS INCLUDING A PEG DERIVATIVE OF TOCOPHEROL," all of which claim priority to U.S. Provisional Application Serial No. 61/070,381, filed March 20, 2008, entitled "COMPOSITIONS CONTAINING NON-POLAR COMPOUNDS" and U.S. Provisional Application Serial No. 61/132,424, filed June 16, 2008, entitled "COMPOSITIONS CONTAINING NON-POLAR COMPOUNDS," each to Philip Bromley. This application also is related to U.S. Patent Application Serial No. 12/383,241, filed March 20, 2009, published as US-2009-0297491-A1, issued as 8,765,661, entitled "COMPOSITIONS CONTAINING NON-POLAR COMPOUNDS" and International PCT Application No. PCT/US2009/001774, filed March 20, 2009, published as International Publication No. WO 2009/117151, entitled "VITAMIN E DERIVATIVESAND THEIR USES," all of which claim priority to U.S. Provisional Application Serial No. 61/070,392, filed March 20, 2008, entitled "COMPOSITIONS CONTAINING NON-POLAR COMPOUNDS" and U.S. Provisional Application Serial No. 61/132,409, filed June 16, 2008, entitled "COMPOSITIONS CONTAINING NON-POLAR COMPOUNDS," each to Philip Bromley. This application also is related to U.S. Patent Application Serial No. 12/456,926, filed June 23, 2009, published as US-2009-0317532-A1, issued as U.S. Patent No. 8,337,931, entitled "COMPOSITIONS CONTAINING NON-POLAR COMPOUNDS" and International PCT Application No. PCT/US2009/003761, filed June 23, 2009, published as International Publication No. WO 2010/008475, entitled "COMPOSITIONS CONTAINING NON-POLAR COMPOUNDS," both of which claim priority to U.S. Provisional Application Serial No. 61/132,953, filed June 23, 2008, entitled "COMPOSITIONS CONTAINING NON-POLAR COMPOUNDS," each to Philip Bromley. This application also is related to U.S. Patent Application Serial No. 13/065,510, filed March 22, 2011, published as US-2011-0236364-A1, entitled "COMPOSITIONS CONTAINING NON-POLAR COMPOUNDS" and International PCT Application No. PCT/US201 1/000538, filed March 22, 2011, published as International Publication No. WO 2011/1 19228, entitled "COMPOSITIONS CONTAINING NON-POLAR COMPOUNDS," all of which claim priority to U.S. Provisional Application Serial No. 61/340,944, filed March 23, 2010, entitled "COMPOSITIONS CONTAINING NON-POLAR COMPOUNDS," each to Philip Bromley. This application also is related to U.S. Patent Application Serial No. 13/134,927, filed June 20, 2011, published as US-2012-0016026-A1, issued as 8,741,373, entitled "COMPOSITIONS CONTAINING NON-POLAR COMPOUNDS" and International PCT Application No. PCT/US20 11/01099, filed June 20, 2011, published as International Publication No. WO 2011/162802, entitled "COMPOSITIONS CONTAINING NON-POLAR COMPOUNDS," all of which claim priority to U.S. Provisional Application Serial No. 61/398,192, filed June 21, 2010, entitled "COMPOSITIONS CONTAINING NON-POLAR COMPOUNDS," each to Philip Bromley. This application also is related to U.S. Patent Application No. 14/449,880, filed August 1, 2014, entitled "COMPOSITIONS CONTAINING WATER-SOLUBLE DERIVATIVESOF VITAMIN E MIXTURES AND MODIFIED FOOD STARCH," which claims priority to U.S. Provisional Application Serial No. 61/863,897, filed August 8, 2013, entitled "COMPOSITIONS CONTAINING WATER-SOLUBLE DERIVATIVESOF VITAMIN E MIXTURES AND MODIFIED FOOD STARCH," each to Philip Bromley. Where permitted, the subject matter of each of the above-referenced applications is incorporated by reference in its entirety. FIELD OF THE INVENTION Provided herein are compositions that contain high amounts of non-polar ingredients and non-aqueous solvents, for example, concentrates. Also provided are compositions for human consumption, such as soft gel capsules and other dosage forms, that contain the non-aqueous concentrates containing high amounts of non- polar ingredients and non-aqueous solvents.
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