Menke's Method of Preparing Hyponitrites
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(10) Patent No.: US 8119385 B2
US008119385B2 (12) United States Patent (10) Patent No.: US 8,119,385 B2 Mathur et al. (45) Date of Patent: Feb. 21, 2012 (54) NUCLEICACIDS AND PROTEINS AND (52) U.S. Cl. ........................................ 435/212:530/350 METHODS FOR MAKING AND USING THEMI (58) Field of Classification Search ........................ None (75) Inventors: Eric J. Mathur, San Diego, CA (US); See application file for complete search history. Cathy Chang, San Diego, CA (US) (56) References Cited (73) Assignee: BP Corporation North America Inc., Houston, TX (US) OTHER PUBLICATIONS c Mount, Bioinformatics, Cold Spring Harbor Press, Cold Spring Har (*) Notice: Subject to any disclaimer, the term of this bor New York, 2001, pp. 382-393.* patent is extended or adjusted under 35 Spencer et al., “Whole-Genome Sequence Variation among Multiple U.S.C. 154(b) by 689 days. Isolates of Pseudomonas aeruginosa” J. Bacteriol. (2003) 185: 1316 1325. (21) Appl. No.: 11/817,403 Database Sequence GenBank Accession No. BZ569932 Dec. 17. 1-1. 2002. (22) PCT Fled: Mar. 3, 2006 Omiecinski et al., “Epoxide Hydrolase-Polymorphism and role in (86). PCT No.: PCT/US2OO6/OOT642 toxicology” Toxicol. Lett. (2000) 1.12: 365-370. S371 (c)(1), * cited by examiner (2), (4) Date: May 7, 2008 Primary Examiner — James Martinell (87) PCT Pub. No.: WO2006/096527 (74) Attorney, Agent, or Firm — Kalim S. Fuzail PCT Pub. Date: Sep. 14, 2006 (57) ABSTRACT (65) Prior Publication Data The invention provides polypeptides, including enzymes, structural proteins and binding proteins, polynucleotides US 201O/OO11456A1 Jan. 14, 2010 encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. -
Nitroxyl (Hno) and Carbonylnitrenes
INVESTIGATION OF REACTIVE INTERMEDIATES: NITROXYL (HNO) AND CARBONYLNITRENES by Tyler A. Chavez A dissertation submitted to the Johns Hopkins University in conformity with the requirements for the degree of Doctor of Philosophy Baltimore, Maryland February 2016 © 2016 Tyler A. Chavez All rights reserved Abstract Membrane inlet mass spectrometry (MIMS) is a well-established method used to detect gases dissolved in solution through the use of a semipermeable hydrophobic membrane that allows the dissolved gases, but not the liquid phase, to enter a mass spectrometer. Interest in the unique biological activity of azanone (nitroxyl, HNO) has highlighted the need for new sensitive and direct detection methods. Recently, MIMS has been shown to be a viable method for HNO detection with nanomolar sensitivity under physiologically relevant conditions (Chapter 2). In addition, this technique has been used to explore potential biological pathways to HNO production (Chapter 3). Nitrenes are reactive intermediates containing neutral, monovalent nitrogen atoms. In contrast to alky- and arylnitrenes, carbonylnitrenes are typically ground state singlets. In joint synthesis, anion photoelectron spectroscopic, and computational work we studied the three nitrenes, benzoylnitrene, acetylnitrene, and trifluoroacetylnitrene, with the purpose of determining the singlet-triplet splitting (ΔEST = ES – ET) in each case (Chapter 7). Further, triplet ethoxycarbonylnitrene and triplet t-butyloxycarbonylnitrene have been observed following photolysis of sulfilimine precursors by time-resolved infrared (TRIR) spectroscopy (Chapter 6). The observed growth kinetics of nitrene products suggest a contribution from both the triplet and singlet nitrene, with the contribution from the singlet becoming more prevalent in polar solvents. Advisor: Professor John P. Toscano Readers: Professor Kenneth D. -
Nthetic Approach Towards the Formation of Cobalt Peroxynitrite Intermediate a Dissertation
Synthetic Approach towards the Formation of Cobalt Peroxynitrite Intermediate A dissertation submitted to the Indian Institute of Technology Guwahati as Partial fulfillment for the degree of Doctor of Philosophy in Chemistry Submitted by Soumen Saha (Roll No. 126122002) Supervisor Prof. Biplab Mondal Department of Chemistry Indian Institute of Technology Guwahati December, 2017 TH-1730_126122002 Dedicated to My Family, Friends & Teachers TH-1730_126122002 STATEMENT I hereby declare that this thesis entitled “Synthetic Approach towards the Formation of Cobalt Peroxynitrite Intermediate” is the outcome of research work carried out by me under the supervision of Prof. Biplab Mondal in the Department of Chemistry, Indian Institute of Technology Guwahati, India. In keeping with the general practice of reporting scientific observations, due acknowledgements have been made wherever the work described is based on the findings of other investigators. December, 2017 Soumen Saha Indian Institute of Technology Guwahati TH-1730_126122002 Acknowledgement The success and final outcome of this thesis required a lot of guidance and assistance from many people and I am extremely privileged to have got this all along the completion of my thesis. All that I have done is only due to such supervision and assistance and I would not forget to thank them. First and foremost I would like to thank my thesis supervisor, Prof. Biplab Mondal, who fearlessly accepted me as Ph.D student under his guidance and was the main creator of the great ideas, techniques and whole background of this thesis. We experienced together all the ups and downs of routine work, the shared happiness of success and the depression of failure. -
List of Reactive Chemicals
LIST OF REACTIVE CHEMICALS Chemical Prefix Chemical Name Reactive Reactive Reactive CAS# Chemical Chemical Chemical Stimulus 1 Stimulus 2 Stimulus 3 111-90-0 "CARBITOL" SOLVENT D 111-15-9 "CELLOSOLVE" ACETATE D 110-80-5 "CELLOSOLVE" SOLVENT D 2- (2,4,6-TRINITROPHENYL)ETHYL ACETATE (1% IN ACETONE & BENZENE S 12427-38-2 AAMANGAN W 88-85-7 AATOX S 40487-42-1 AC 92553 S 105-57-7 ACETAL D 75-07-0 ACETALDEHYDE D 105-57-7 ACETALDEHYDE, DIETHYL ACETAL D 108-05-4 ACETIC ACID ETHENYL ESTER D 108-05-4 ACETIC ACID VINYL ESTER D 75-07-0 ACETIC ALDEHYDE D 101-25-7 ACETO DNPT T 126-84-1 ACETONE DIETHYL ACETAL D 108-05-4 ACETOXYETHYLENE D 108-05-4 1- ACETOXYETHYLENE D 37187-22-7 ACETYL ACETONE PEROXIDE, <=32% AS A PASTE T 37187-22-7 ACETYL ACETONE PEROXIDE, <=42% T 37187-22-7 ACETYL ACETONE PEROXIDE, >42% T S 644-31-5 ACETYL BENZOYL PEROXIDE (SOLID OR MORE THAN 45% IN SOLUTION) T S 644-31-5 ACETYL BENZOYL PEROXIDE, <=45% T 506-96-7 ACETYL BROMIDE W 75-36-5 ACETYL CHLORIDE W ACETYL CYCLOHEXANE SULFONYL PEROXIDE (>82% WITH <12% WATER) T S 3179-56-4 ACETYL CYCLOHEXANE SULFONYL PEROXIDE, <=32% T 3179-56-4 ACETYL CYCLOHEXANE SULFONYL PEROXIDE, <=82% T 674-82-8 ACETYL KETENE (POISON INHALATION HAZARD) D 110-22-5 ACETYL PEROXIDE, <=27% T 110-22-5 ACETYL PEROXIDE, SOLID, OR MORE THAN 27% IN SOLUTION T S 927-86-6 ACETYLCHOLINE PERCHLORATE O S 74-86-2 ACETYLENE D 74-86-2 ACETYLENE (LIQUID) D ACETYLENE SILVER NITRATE D 107-02-08 ACRALDEHYDE (POISON INHALATION HAZARD) D 79-10-7 ACROLEIC ACID D 107-02-08 ACROLEIN, INHIBITED (POISON INHALATION HAZARD) D 107-02-08 ACRYLALDEHYDE (POISON INHALATION HAZARD) D 79-10-7 ACRYLIC ACID D 141-32-2 ACRYLIC ACID BUTYL ESTER D 140-88-5 ACRYLIC ACID ETHYL ESTER D 96-33-3 ACRYLIC ACID METHYL ESTER D Stimulus - Stimuli is the thermal, physical or chemical input needed to induce a hazardous reaction. -
Hyponitrites ; Their Properties, and Their Pre- Paration by Sodium Or Potassium
View Article Online / Journal Homepage / Table of Contents for this issue DIVERS : HYPONITRfTES ; THEfR PROPERTfES, ETC. $5 XV.-Hyponitrites ; their Properties, and their Pre- paration by Sodium or Potassium. Published on 01 January 1899. Downloaded by Heinrich Heine University of Duesseldorf 12/11/2013 22:18:32. By EDWARDDIVERS, M.D.; D.Sc., F.R.8. THE hyponitrites have received the attention of many chemists besides myself since their discovery in 1871, and even this year new ways of forming them and the new working of an old method have been published, Yet much has been left to be put on record before a fairly correct and full history of these salts can be said to have been given, and the present paper is meant to be the necessary supplement to what has already been published. Way8 fmming Hyponitrites. No writer on hyponitrites in recent years has ahown himself acquainted with all the known ways of getting these salts, or even with the most productive. The following complete list is valuable, H2 View Article Online 96 DIVERS : HYPONITRITES ; THEIR PROPERTIES, AND THEIR therefore, and is of special interest as bringing togehr the various modes of formation of these salts. 1, Reduction of an alkali nitrite by the amalgam of its metal (Divers, 1871). 2. Reduction of an alkali nitrite by ferrous hydroxide (Zorn, 1882 ; Dunstap and Dymond). 3. Reduction of (hypo)nitrososulphates by sodium amalgam (Divers and Haga, 1885). 4. Reduction of nitric oxide by alkali stannite (Divers and Hagn, 1885). 5. Reduction of nitric oxide by ferrous hydroxide (Dunstan and Dymond, 1887). -
Redox Chemistry of Hyponitrite: Part Ill-Oxidation by Hexacyanoferrateilll) in Aqueous Alkaline Solution
Indian Journal of Chemistry Vol. 28A, April 1989, pp. 280-283 Redox chemistry of hyponitrite: Part ill-oxidation by hexacyanoferrateilll) in aqueous alkaline solution M R Goyal, Pankaj Bhatnagar, R K Mittal & Y K Gupta" Department of Chemistry, University of Rajasthan, Jaipur 302 004 Received 22 April 1988; revised 22 June 1988; accepted 8 July 1988 Oxidation of hyponitrite by hexacyanoferrate(ill) in alkaline solution occurs by two paths resulting in a stoichiometry of 1.21:1(oxidant.substrate), The finalproducts are N20,N2and NO; ,and the intermediates .'" are N02- and peroxonitrite. Rate has first order dependence in [Fe(CN)i - J and [N20~- J and no dependence on [OH - J. The second order rate constant isfound to be (0.87 ± 0.025) dm-mol" at 35° and 1=0.515 mol dm - 3. Rate significantlyincreases in the presence of alkali metal cations. Studies on oxidation of hyponitrite by thalliumlllf)' strength as in the reaction mixture before measuring and ceriumll'Vj' in aqueous acidic solutions have in- absorbance. Initial rates were obtained by the plane directly indicated the formation of intermediates mirror method" and the results were reproducible H2N203 and HN02 or its isomer, though the final within ±3%. identified products are nitrate", N 0 and N . Oxida- 2 2 Results tion" by chloramine-T (CAT) provides no informa- Stoichiometry and products tion about the intermediates and the only product is The stoichiometry was determined using excess of found to be nitrate. These studies reveal that the inter- hexacyanoferratetlfl). Excess hypo nitrite could not mediates appear to be unstable in acidic solutions and be employed because of interference in its determina- hence an investigation in alkaline solution seemed to tion by hexacyanoferrate(II). -
Nitroxyl (HNO): a Reduced Form of Nitric Oxide with Distinct Chemical, Pharmacological, and Therapeutic Properties
Hindawi Publishing Corporation Oxidative Medicine and Cellular Longevity Volume 2016, Article ID 4867124, 15 pages http://dx.doi.org/10.1155/2016/4867124 Review Article Nitroxyl (HNO): A Reduced Form of Nitric Oxide with Distinct Chemical, Pharmacological, and Therapeutic Properties Mai E. Shoman and Omar M. Aly Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt Correspondence should be addressed to Omar M. Aly; [email protected] Received 5 May 2015; Revised 14 August 2015; Accepted 1 September 2015 Academic Editor: Lezanne Ooi Copyright © 2016 M. E. Shoman and O. M. Aly. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Nitroxyl (HNO), the one-electron reduced form of nitric oxide (NO), shows a distinct chemical and biological profile from that of NO. HNO is currently being viewed as a vasodilator and positive inotropic agent that can be used as a potential treatment for heart failure. The ability of HNO to react with thiols and thiol containing proteins is largely used to explain the possible biological actions of HNO. Herein, we summarize different aspects related to HNO including HNO donors, chemistry, biology, and methods used for its detection. 1. Nitric Oxide (NO) cGMP in platelets, and this is thought to be the mechanism by which it inhibits platelet function [7]. In the vasculature, Biological activities associated with nitrogen oxide species are NO also prevents neutrophil/platelet adhesion to endothelial the subject of intense and current research interest. -
An Experimental and Computational Comparison of the Reactions of N2O and CO2 in Several Inorganic Systems
Please do not remove this page An Experimental and Computational Comparison of the Reactions of N2O and CO2 in Several Inorganic Systems Davis, Jack Vickery https://scholarship.miami.edu/discovery/delivery/01UOML_INST:ResearchRepository/12386108050002976?l#13386108040002976 Davis, J. V. (2021). An Experimental and Computational Comparison of the Reactions of N2O and CO2 in Several Inorganic Systems [University of Miami]. https://scholarship.miami.edu/discovery/fulldisplay/alma991031605661102976/01UOML_INST:ResearchR epository Open Downloaded On 2021/10/02 02:14:36 -0400 Please do not remove this page UNIVERSITY OF MIAMI AN EXPERIMENTAL AND COMPUTATIONAL COMPARISON OF THE REACTIONS OF N2O AND CO2 IN SEVERAL INORGANIC SYSTEMS By Jack Vickery Davis A DISSERTATION Submitted to the Faculty of the University of Miami in partial fulfillment of the requirements for the degree of Doctor of Philosophy Coral Gables, Florida August 2021 ©2021 Jack Vickery Davis All Rights Reserved UNIVERSITY OF MIAMI A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy AN EXPERIMENTAL AND COMPUTATIONAL COMPARISON OF THE REACTIONS OF N2O AND CO2 IN SEVERAL INORGANIC SYSTEMS Jack Vickery Davis Approved: ________________ _________________ Carl D Hoff, Ph.D. Roger M. Leblanc, Ph.D. Professor of Chemistry Professor of Chemistry ________________ _________________ Burjor K. Captain, Ph.D. Guillermo Prado, Ph.D. Associate Professor of Chemistry Dean of the Graduate School ________________ Manuel Temprado, Ph.D. Associate Professor of Chemistry University of Alcalá DAVIS, JACK VICKERY (Ph.D., Chemistry) An Experimental and Computational Comparison of the (August 2021) Reactions of N2O and CO2 in Several Inorganic Systems Abstract of a dissertation at the University of Miami. -
United States Patent Office Patented Nov
2,913,481 United States Patent Office Patented Nov. 17, 1959 arimanoramitroverwar 2 the solvent at low temperature or by crystallisation at 2,913,481 low temperature. The pure hyponitrous esters are how ever dangerous detonating explosives and isolation is ESTERS OF HYPONTROUSACD usually avoided. Hyponitries can be prepared from un John Wooley Batty, Arthur Lambert, and Gerald Scott, 5 stable halides which can be generated in situ. Blackley, Manchester, and Leslie Seed, Northwich, Eng The yield of the new hyponitrites is greater than the land, assignors to Imperial Chemical Industries Lim: yield of alkyl hyponitrites described in the prior art when ited, Milburne, London, England, a corporation of prepared by the same general reaction. Thus, for ex Great Britain ample, whereas the yield of isobutyl hyponitrite by inter No Drawing. Application April 29, 1957 0 action between silver hyponitrite and isobutyl iodide is Serial No. 655,478 about 10%, the yield of methoxymethylhyponitrite from chloromethyl ether under similar conditions is about 95%. Claims priority, application Great Britain May 2, 1956 Other hyponitrites included within the general class 8 Claims. (CI. 260-466) provided by this invention include esters (which may be 5 polymeric) of the general structure This invention relates to esters and more particularly to hyponitrous esters especially useful as catalysts for X-O-CHY-O-N-N-O-CHY-O-X the polymerisation of ethylenically unsaturated com wherein X may be alkyl, alkoxyalkyl, cycloalkyl or aryl pounds. and Y may be hydrogen, alkyl, cycloalkyl, aryl, alkoxy, This application is a continuation-in-part of our appli 20 alkoxyalkyl or may form part of a ring with X. -
Potassium Hydroxide Pellets
SAFETY DATA SHEET Preparation Date: 3/13/2015 Revision Date: 3/13/2015 Revision Number: G1 Product identifier Product code: P1315 Product Name: POTASSIUM HYDROXIDE, PELLETS, REAGENT, ACS Other means of identification Synonyms: Caustic Potash CAS #: 1310-58-3 RTECS # TT2100000 CI#: Not available Recommended use of the chemical and restrictions on use Recommended use: Electroplating; photoengraving & lithography; printing inks; in analytical chemistry & in organic synthesis; manfufacturing of liquid soap; pharmaceutical aid (as alkalizing agent); mordant for woods; absorbing carbon dioxide; mercerizing cotton; paint & varnish removers. Principle uses of KOH include chemicals, particularly the production of potassium carbonate and potassium permaganate; pesticides, fertilizers, and other agricultural products; soaps and detergents; scrubbing and cleaning operations, e.g., industrial gases; dyes and colorants; and rubber chemicals. Uses advised against No information available Supplier: Spectrum Chemicals and Laboratory Products, Inc. 14422 South San Pedro St. Gardena, CA 90248 (310) 516-8000 Order Online At: https://www.spectrumchemical.com Emergency telephone number Chemtrec 1-800-424-9300 Contact Person: Martin LaBenz (West Coast) Contact Person: Ibad Tirmiz (East Coast) 2. HAZARDS IDENTIFICATION Classification This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200) Acute toxicity - Oral Category 3 Skin corrosion/irritation Category 1 Serious eye damage/eye irritation Category 1 Corrosive -
Mechanism and Stereochemistry of the Reaction Ofnitric Oxide with Secondary Amines
Mechanism and Stereochemistry of the Reaction ofNitric Oxide with Secondary Amines By Kamilah Smith A thesis submitted ta McGill University in partial fulfillment ofthe requirements for the degree of Doctor of Philosophy Department of Chemistry McGill University Montreal, Quebec Canada © Kamilah Smith, February 2007 Library and Bibliothèque et 1+1 Archives Canada Archives Canada Published Heritage Direction du Branch Patrimoine de l'édition 395 Wellington Street 395, rue Wellington Ottawa ON K1A ON4 Ottawa ON K1A ON4 Canada Canada Your file Votre référence ISBN: 978-0-494-32326-7 Our file Notre référence ISBN: 978-0-494-32326-7 NOTICE: AVIS: The author has granted a non L'auteur a accordé une licence non exclusive exclusive license allowing Library permettant à la Bibliothèque et Archives and Archives Canada to reproduce, Canada de reproduire, publier, archiver, publish, archive, preserve, conserve, sauvegarder, conserver, transmettre au public communicate to the public by par télécommunication ou par l'Internet, prêter, telecommunication or on the Internet, distribuer et vendre des thèses partout dans loan, distribute and sell th es es le monde, à des fins commerciales ou autres, worldwide, for commercial or non sur support microforme, papier, électronique commercial purposes, in microform, et/ou autres formats. paper, electronic and/or any other formats. The author retains copyright L'auteur conserve la propriété du droit d'auteur ownership and moral rights in et des droits moraux qui protège cette thèse. this thesis. Neither the thesis Ni la thèse ni des extraits substantiels de nor substantial extracts from it celle-ci ne doivent être imprimés ou autrement may be printed or otherwise reproduits sans son autorisation. -
LIGAND FORMULA INDEX Order of Elements: C,Il,O,N, Others In
LIGAND FORMULA INDEX Order of elements: C,Il,O,N, others in alphabetical order. - AsF6 74 HO 1 Br - 115 HOBr 134 Br6Ir 135 HOC1 134 HOI 134 CHON 28 H02N 47 CHN 26 H0 2C1 134 CHNS 29 H031 126 CH203 37 H04NF 2S2 135 - CH2N2 135 H0 4S 79 CH2S3 131 H0 4Se 93 CH2S4 131 H0 4Tc 135 CH2Se3 131 HF 96 CNSe 35 HN3 45 C2N3 36 H20Z 75 C4H204Fe 135 H2OZN2 53, 135 - C4N3 36 H203N2 135 C5H05Mn 135 H203FP 132 C6H4 N6Fe 21 H203S 78 3- C6N6Co 24 HZ03SZ 86 3- C6N6Fe 22 HZ03Se 91 C8H3N8W 135 H204Cr 17 C8H4N8W 135 H204Mn 135 H204Mo 18 C1 104 H204S2 135 3- C1 6Ir 135 H204W 19 H205S 133 F6P 74 H208S2 89 253 254 LIGAND FORMULA INDEX H2S 76 H4N2 43 H2S4 133 H50NlS 132 H2S5 133 H502Nl 132 H2Se 90 H505Sb 133 H2Te 94 H505Ta 135 H30N 44 H506NP 2 71 H302P 54 H5061 129 H303NS 88 H501oP3 63 H303As 132 H606N3P3 72 H303B 25 H606Te 134 H30l 55 H6013P4 66 H30lS 132 H6018P6 70 H304NS 133 H708Nl3 71 H304As 133 H7016P5 135 H304P 56 H8019Nb 6 131 H304V 15 H8019P6 135 H305P 131 H8024P8 70 H309P3 68 H1604l14 135 H3N 40 H620121P60 135 HlS4 132 H403NP 132 I 122 H404Ge 131 H404Si 39 ON 135 H 0 Te - 4 4 95 °3N 48 H 0 P 4 6 2 72, 73 °3Br 121 H 0 P S 4 6 2 2 135 °3C1 113 H 0 P 2- 4 7 2 59 °3SSe 88 H 0 P 4 8 2 73 °4C1 114 H 0 FP - 4 9 3 135 °4Mn 135 H 0 P 69 - 4 12 4 °4Re 20 LIGAND NAME INDEX Ammonia, 40 Hydrogen amidophosphate, 132 Antimonic acid, 133 Hydrogen amidosu1fate, 88 Arsenic acid, 133 Hydrogen antimonate, 133 Arsenous acid, 132 Hydrogen arsenate, 133 Hydrogen arsenite, 132 Boric acid, 25 Hydrogen azide, 45 Bromate ion, 121 Hydrogen borate, 25 Bromide ion, 115 Hydrogen carbonate,