SERP1 (Stress-Associated endoplasmic Reticulum 1, Ribosome-attached Membrane Protein 4, SERP1, RAMP4)

Catalog number 225742 Supplier United States Biological

Newly synthesized emerging through the endoplasmic reticulum (ER) membrane enter a unique environment for folding and assembly by associated proteins. RAMP4 (ribosome-attached membrane protein 4), also designated SERP1 (stress-associated endoplasmic reticulum protein family member 1) and RAMP4-2 (ribosome-associated membrane protein 4-2), also known as SERP2 (stress-associated endoplasmic reticulum protein family member 2), are single-pass type IV membrane proteins that localize to the ER and belong to the RAMP4 family. RAMP4 and RAMP4-2 may interact with target proteins during translocation into the lumen of the ER and protect unfolded target proteins against degradation during ER stress. After termination of ER stress, RAMP4 and RAMP4-2 are involved in facilitating glycosylation of target proteins. RAMP4 consists of 66 amino acids and is encoded by a located on human 3, whereas RAMP4-2 is encoded by a gene located on human chromosome 13 and is composed of 61 amino acids. Applications Suitable for use in Western Blot. Other applications not tested. Recommended Dilution Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Immunogen A synthetic peptide corresponding to residues in Human SERP1. Formulation Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2. Purity Purified by immunoaffinity chromatography. Specificity Recognizes endogenous levels of SERP1. Species Crossreactivity: Human, mouse, rat Product Type Pab Source human Isotype IgG Grade Affinity Purified Applications WB Crossreactivity Hu Mo Rt Storage -20°C MW 11

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