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88 July 2017 Volume 88 Issue 7

7

Volume 88 Issue 7 Contents Volume 88 Issue 7 | JNNP July 2017 Pages 537–616 JOURNAL OF & Editorial commentaries Cognitive neurology J Neurol Neurosurg Psychiatry: first published as on 1 July 2017. Downloaded from

ISSUE 537 ALS genetic epidemiology ‘How simplex is the 586 Auditory training changes temporal lobe HIGHLIGHTS Dementia – A new Tesla genetic epidemiology of ALS?’ connectivity in ‘Wernicke’s aphasia’: ALS – Exploring cardiovascular Aphasia – Home therapy Dystonia – True psychiatry J H Veldink Muscle – What is the issue? a randomised trial

July 2017 Z V J Woodhead, J Crinion, S Teki, W Penny, jnnp.bmj.com 538 Is cardiovascular fitness a risk factor for ALS? C J Price, A P Leff Cover image: tree. M R Turner Movement disorders Editor 539 Home-based therapy for chronic Wernicke’s 595 Psychiatric associations of adult-onset focal Matthew C Kiernan (Australia) aphasia dystonia Deputy Editors L Bonilha, J Fridriksson B D Berman, J Junker, E Shelton, S H Sillau, Karen L Furie (USA) H A Jinnah, J S Perlmutter, A J Espay, J Jankovic, Satoshi Kuwabara (Japan) M Vidailhet, C Bonnet, W Ondo, I A Malaty, Lawrence Wong (China) Neurogenetics R Rodríguez, W M McDonald, L Marsh, Associate Editors 540 Genetic epidemiology of amyotrophic M Zurowski, T Bäumer, N Brüggemann Alan Carson (UK) lateral sclerosis: a systematic review and Nick Ward (UK) Peter Warnke (USA) meta-analysis Z-Y Zou, Z-R Zhou, C-H Che, C-Y Liu, R-L He, Occasional essay Commissioning Editor H-P Huang 603 Six issues in muscle disease Martin Turner (UK) M Swash Web Editors Clare Caldwell Arun Krishnan 550 Exploring the fitness hypothesis in ALS: a Neurological education Cindy Lin 608 The London Contribution to Neurology and Steve Vucic population-based case-control study of parental Psychiatry: The second British Symposium on Editors, Practical Neurology cause of death and lifespan Geraint Fuller (UK) A E Visser, M Seelen, A Hulsbergen, J de Graaf, the History of Neurology and Psychiatry Phil Smith (UK) A J van der Kooi, J Raaphorst, J H Veldink, E H Reynolds Editorial Office L H van den Berg Journal of Neurology Neurosurgery & PostScript Psychiatry 557 The changing picture of amyotrophic lateral 613 Letters BMJ Publishing Group Ltd sclerosis: lessons from European registers BMA House http://jnnp.bmj.com/ Tavistock Square O Hardiman, A Al-Chalabi, C Brayne, E Beghi, London WC1H 9JR, UK L H van den Berg, A Chio, S Martin, G Logroscino, T: +44 (0)20 7383 6909 J Rooney F: +44 (0)20 7383 6668 E: [email protected] 564 7T MRI for neurodegenerative dementias in Twitter: @JNNP_BMJ vivo: a systematic review of the literature ISSN: 0022-3050 (print) E F McKiernan, J T O’Brien ISSN: 1468-330X (online) on September 24, 2021 by guest. Protected copyright. Impact factor: 6.431

Disclaimer: JNNP is published by BMJ Publishing Neuromuscular Group Ltd, a wholly owned subsidiary of the British Medical Association. The BMJ Group grants editorial 575 Genetic and clinical characteristics of NEFL- freedom to the Editor of JNNP. JNNP follows related Charcot-Marie-Tooth disease guidelines on editorial independence produced by This article has been chosen by the Editor to be of special interest­ the World Association of Medical Editors and the A Horga, M Laurà, Z Jaunmuktane, N U Jerath, code on good publication practice of the Committee or importance and is freely available online. on Publication Ethics. M A Gonzalez, J M Polke, R Poh, J C Blake, JNNP is intended for medical professionals and is Y-T Liu, S Wiethoff, C Bettencourt, M P T Lunn, This article has been chosen in conjunction with the BMJ Patient provided without warranty, express or implied. H Manji, M G Hanna, H Houlden, S Brandner, Forum to be of particular interest to patients and is freely available Statements in the journal are the responsibility of their authors and advertisers and not authors’ S Züchner, M Shy, M M Reilly online. institutions, the BMJ Publishing Group or the BMA unless otherwise specified or determined by law. This article has been made freely available online under the Acceptance of advertising does not imply BMJ Journals Open Access scheme. endorsement. See http://jnnp.bmj.com/site/about/guidelines.xhtml#open To the fullest extent permitted by law, the BMJ Publishing Group shall not be liable for any loss, injury or damage resulting from the use of JNNP or any The article is part of the Impact Commentaries series information in it whether based on contract, tort or otherwise. Readers are advised to verify any information they choose to rely on. Copyright: © 2017 BMJ Publishing Group. All COPE rights reserved; no part of this publication may be reproduced, stored in a retrieval system, or Member since 2008 transmitted in any form or by any means, electronic, JM00010JM00017 mechanical, photocopying, recording, or otherwise This journal is a member of and subscribes to the principles of the without prior permission. Committee on Publication Ethics JNNP is published by BMJ Publishing Group Ltd, typeset by Exeter Premedia Services Private Ltd, http://publicationethics.org/ Chennai, India and printed in the UK on acid-free paper from sustainable forests. Journal of Neurology Neurosurgery & Psychiatry (ISSN No: 0022-3050) is published monthly by BMJ Publishing Group and is distributed in the USA by Air Business Ltd. Periodicals postage paid at Jamaica NY 11431 POSTMASTER: send address changes to Journal of Neurology Neurosurgery & Psychiatry, Air Business Ltd, c/o Worldnet Shipping Inc., 156-15, 146th Avenue, 2nd Floor, Jamaica, NY 11434, USA.