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May 2021 Volume 92 Issue 5 92 Impact 5 Factor 8.263 JOURNAL OF Volume 92 Contents Volume 92 Issue 5 | JNNP May 2021

Issue 5 N eu rology

Pages 457–569 & JOURNAL OF NEUROSURGERY & PSYCHIATRY Editorial commentaries J Neurol Neurosurg Psychiatry: first published as on 1 May 2021. Downloaded from 457 It is safe to switch from interferon beta 485 Plasma microRNA signature in presymptomatic or glatiramer acetate to oral therapy in patients and symptomatic subjects with - with relapsing with stable associated frontotemporal and

May 2021 disease amyotrophic lateral sclerosis jnnp.bmj.com N Koch-Henriksen V Kmetzsch, V Anquetil, D Saracino, D Rinaldi, A Camuzat, T Gareau, L Jornea, S Forlani, P Couratier, D Wallon, F Pasquier, N Robil, Editor 458 Plasma microRNA signature as biomarker Matthew C Kiernan (Australia) for disease progression in frontotemporal P de la Grange, I Moszer, I Le Ber, O Colliot, E Becker, The PREV-DEMALS study group Deputy Editors dementia and amyotrophic lateral sclerosis Karen L Furie (USA) R Dewan, B J Traynor Satoshi Kuwabara (Japan) 494 Modelling the cascade of biomarker changes in Lawrence Wong (China) GRN-related Associate Editors 459 Fashion focus: neurosurgery for J L Panman, V Venkatraghavan, E L van der Ende, Alan Carson (UK) L Zrinzo Nick Ward (UK) R M E Steketee, L C Jiskoot, J M Poos, Peter Warnke (USA) E G P Dopper, L H H Meeter, L Donker Kaat, Commissioning Editor S A R B Rombouts, M W Vernooij, A J A Kievit, Martin Turner (UK) Cognition E Premi, M Cosseddu, E Bonomi, J Olives, Web Editors J D Rohrer, R Sánchez-Valle, B Borroni, E E Bron, Clare Caldwell 460 Cognitive reserve in amyotrophic lateral J C Van Swieten, J M Papma, S Klein, GENFI Arun Krishnan sclerosis (ALS): a population-based longitudinal consortium investigators Cindy Lin study Steve Vucic E Costello, J Rooney, M Pinto-Grau, T Burke, Podcast Editor M Elamin, P Bede, R McMackin, S Dukic, A Vajda, 502 Unravelling the clinical spectrum and the role Colin Mahoney of repeat length in C9ORF72 repeat expansions JNNP Blog Editors M Heverin, O Hardiman, N Pender Jose Manuel Matamala E L van der Ende, J L Jackson, A White, H Seelaar, Thanuja Dharmadasa M van Blitterswijk, J C Van Swieten JNNP Facebook Editors Cindy Lin 510 Value of systematic genetic screening of William Huynh 466 Effect of erenumab on functional outcomes in Editors, Practical Neurology patients with episodic migraine in whom 2–4 patients with amyotrophic lateral sclerosis Geraint Fuller (UK) S R Shepheard, M D Parker, J Cooper-Knock, Phil Smith (UK) preventives were not useful: results from the N S Verber, L Tuddenham, P Heath, N Beauchamp,

Editorial Office LIBERTY study E Place, E S A Sollars, M R Turner, A Malaspina, http://jnnp.bmj.com/ Journal of Neurology Neurosurgery & M Lanteri-Minet, P J Goadsby, U Reuter, S Wen, P Fratta, C Hewamadduma, T M Jenkins, Psychiatry P Hours-Zesiger, M D Ferrari, J Klatt C J McDermott, D Wang, J Kirby, P J Shaw, on BMJ Publishing Group Ltd BMA House behalf of the Project MINE Consortium Tavistock Square London WC1H 9JR, UK Neuromuscular E: [email protected] Twitter: @JNNP_BMJ 473 Chronic inflammatory demyelinating

ISSN: 0022-3050 (print) polyneuropathy and pregnancy: systematic on September 26, 2021 by guest. Protected copyright. ISSN: 1468-330X (online) review Impact factor: 8.263 MORE CONTENTS ► F Kohle, S Kuwabara, H C Lehmann Disclaimer: The Editor of JNNP has been granted editorial freedom and JNNP is published in accordance with editorial guidelines issued by the World Association of Medical Editors and the Committee This article has been chosen by the Editor to be of special interest­ on Publication Ethics. JNNP is primarily intended or importance and is freely available online. for healthcare professionals and its content is for information only. The Journal is published without any 479 Effect of familial clustering in the genetic guarantee as to its accuracy or completeness and any This article has been chosen in conjunction with the BMJ Patient representations or warranties are expressly excluded screening of 235 French ALS families Forum to be of particular interest to patients and is freely available to the fullest extent permitted by law. Readers are P Corcia, W Camu, C Brulard, S Marouillat, advised to independently verify any information on online. which they choose to rely. Acceptance of advertising P Couratier, J-P Camdessanché, P Cintas, by JNNP does not imply endorsement. BMJ Publishing This article has been made freely available online under the Group Limited shall not be liable for any loss, injury or A Verschueren, M-H Soriani, C Desnuelle, BMJ Journals open access scheme. damage howsoever arising from JNNP (except for M-C Fleury, N Guy, J Cassereau, F Viader, See http://authors.bmj.com/open-access/ liability which cannot be legally excluded). Copyright: © 2021 BMJ Publishing Group Ltd. All S Pittion-Vouyovitch, V Danel, I Kolev, rights reserved; no part of this publication may be G Le Masson, S Beltran, F Salachas, E Bernard, The article is part of the Impact Commentaries series reproduced in any form without permission. P-F Pradat, H Blasco, D Lanznaster, JNNP is published by BMJ Publishing Group Ltd, typeset by Exeter Premedia Services Private Ltd, R Hergesheimer, F Laumonnier, C R Andres, Chennai, India and printed in the UK on acid-free COPE paper from sustainable forests. V Meininger, P Vourc'h Journal of Neurology Neurosurgery & Psychiatry ISSN 0022-3050 (USPS 2156) is published monthly Member since 2008 JM00017JM00010 by BMJ Publishing Group Ltd, BMA House, Tavistock Square, WC1H 9JR London. Airfreight and mailing This journal is a member of and subscribes to the principles of the in the USA by agent named World Container Inc, Committee on Publication Ethics 150-15, 183rd Street, Jamaica, NY 11413, USA. http://publicationethics.org/ Periodicals postage paid at Brooklyn, NY 11256. US Postmaster: Send address changes to Journal of Neurology Neurosurgery & Psychiatry, World Container Inc, 150-15, 183rd Street, Jamaica, NY 11413, USA. Subscription records are maintained at BMA House, Tavistock Square, WC1H 9JR London. Air Business Ltd is acting as our mailing agent. The online version of this article contains multiple choice ­questions hosted on BMJ Learning. Contents Volume 92 Issue 5 | JNNP May 2021

Neuropsychiatry Movement disorders

519 Psychotropic and medication use in 549 Adoption of focused ultrasound thalamotomy J Neurol Neurosurg Psychiatry: first published as on 1 May 2021. Downloaded from individuals with traumatic injury—a Swedish for : why so much fuss about total population cohort study of 240 000 persons FUS? Y Molero, D J Sharp, B M D'Onofrio, H Larsson, C Iorio-Morin, M Hodaie, A M Lozano S Fazel

528 and risk of suicide in older Multiple sclerosis adults: a population-based prospective cohort study 556 Effect of lateral therapy switches to D J Oh, J W Han, J B Bae, T H Kim, K P Kwak, B J Kim, S G Kim, J L Kim, S W Moon, J H Park, oral moderate-efficacy drugs in multiple S-H Ryu, J C Youn, D Y Lee, D W Lee, S B Lee, sclerosis: a nationwide cohort study J J Lee, J H Jhoo, K W Kim M D Buron, T Kalincik, F Sellebjerg, P S Sørensen, M Magyari 534 Recanalisation for acute ischaemic PostScript in patients on direct oral anticoagulants 563 Letters D J Seiffge, T Meinel, J C Purrucker, J Kaesmacher, U Fischer, D Wilson, T Y Wu

542 Prevalence, predictors and prognosis of incidental intracranial aneurysms in patients Electronic page with suspected TIA and minor stroke: a e2 Correction: Brain iron deposition is linked population-based study and systematic review with cognitive severity in Parkinson’s R Hurford, I Taveira, W Kuker, P M Rothwell, On disease behalf of the Oxford Vascular Study Phenotyped Cohort http://jnnp.bmj.com/ on September 26, 2021 by guest. Protected copyright.