DOCSLIB.ORG

Wo 2009/078034 A2

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Wo 2009/078034 A2 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date PCT (10) International Publication Number 25 June 2009 (25.06.2009) WO 2009/078034 A2 (51) International Patent Classification: Building, Goregaon - Mulund Link Road,, Opposite Indira A61K9/00 (2006.01) A61K9/20 (2006.01) Container Yard, Off L.B.S. Marg, Bhandup (W),, Mumbai A61K 9/14 (2006.01) A61K 31/4045 (2006.01) 400 078 (IN). KELKAR, Atul [IN/IN]; 221, Annexe A61K 9/16 (2006.01) Building, Goregaon - Mulund Link Road,, Opposite Indira Container Yard, Off L.B.S. Marg, Bhandup (W),, Mumbai (21) International Application Number: 400 078 (IN). PCT/IN2008/000787 (74) Agent: MAJUMDAR, Subhatosh; S. MAJUMDAR & (22) International Filing Date: CO., 5, Harish Mukherjee Road, Kolkata 700 025 (IN). 26 November 2008 (26.1 1.2008) (81) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind of national protection available): AE, AG, AL, AM, AO, AT,AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, (26) Publication Language: English CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, (30) Priority Data: IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, 2320/MUM/2007 LR, LS, LT, LU, LY,MA, MD, ME, MG, MK, MN, MW, 26 November 2007 (26. 11.2007) IN MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY,TJ, (71) Applicant (for all designated States except US): RUBI¬ TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, CON RESEARCH PRIVATE LIMITED [IN/IN]; 221, ZW Annexe Building, Goregaon - Mulund Link Road,, Oppo site Indira Container Yard, Off L.B.S. Marg, Bhandup (W),, (84) Designated States (unless otherwise indicated, for every Mumbai 400 078 (IN). kind of regional protection available): ARIPO (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, (72) Inventors; and ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), (75) Inventors/Applicants (for US only): PILGAONKAR, European (AT,BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, Pratibha, S. [IN/IN]; 221, Annexe Building, Goregaon - FR, GB, GR, HR, HU, IE, IS, IT, LT,LU, LV,MC, MT, NL, Mulund Link Road,, Opposite Indira Container Yard, Off NO, PL, PT, RO, SE, SI, SK, TR), OAPI (BF, BJ, CF, CG, L.B.S. Marg, Bhandup (W),, Mumbai 400 078 (IN). RUS- CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). TOMJEE, Maharukh, T. [IN/IN]; 221, Annexe Building, Goregaon - Mulund Link Road,, Opposite Indira Container Published: Yard, Off L.B.S. Marg, Bhandup (W),, Mumbai 400 078 — without international search report and to be republished (IN). GANDHI, Anilkumar, S. [IN/IN]; 221, Annexe upon receipt of that report (54) Title: ORAL DISINTEGRATING TABLETS OF ROPINIROLE HYDROCHLORIDE (57) Abstract: The present invention relates to a solid pharmaceutical composition comprising ropinirole, which dissolves or dis- integrates in the oral cavity within about sixty (60) seconds. The present invention further discloses orally disintegrating tablets of ropinirole of optimal mechanical strength comprising taste-masked ropinirole and at least one pharmaceutically acceptable excipient. ORAL DISINTEGRATING TABLETS OF ROPINIROLE HYDROCHLORIDE Field of the invention The present invention relates to a solid pharmaceutical composition comprising ropinirole, which dissolves or disintegrates in the oral cavity within about sixty (60) seconds. The present invention also relates to a process for the preparation of a taste-masked pharmaceutical composition of ropinirole of optimal mechanical strength comprising ropinirole along with a taste-masking agent and at least one pharmaceutically acceptable excipient. Background of the Invention The geriatric population, composed of people aged sixty-five (65) years and over, is rapidly growing in the United States and throughout the world. According to the United Nations World Prospects published in 2005, the global population of people over the age of sixty (60) in 2005 was estimated to be 672 million out of a total of approximately 6.5 billion and is expected to reach 1.9 billion by 2050 (cited in: Population Division of the Department of Economic and Social Affairs of the United Nations Secretariat. The World Population Prospects: the 2004 revision). This population presents unique treatment challenges for caregivers and physicians. The prevalence of psychiatric illness ranges from 65-90%, with dementia complicated by depression, psychosis, and behavioral disturbances, the most common disorder. Majority of them also suffer from movement disorders, which are neurological conditions that affect the speed, fluency, quality, and ease of movement. Abnormal fluency or speed of movement (dyskinesia) may involve excessive or involuntary movement (hyperkinesia) or slowed or absent voluntary movement (hypokinesia). Non- limiting examples of movement disorders include ataxia (lack of coordination, often producing jerky movements), dystonia (causes involuntary movement and prolonged muscle contraction), Huntington's disease (chronic progressive chorea), multiple system atrophies (e.g., Shy-Drager syndrome), myoclonus (rapid, brief, irregular movement), Parkinson's disease, progressive supranuclear palsy (rare disorder that affects purposeful movement), Restless leg syndrome (RSD) and periodic limb movement disorder (PLMD), tics (involuntary muscle contractions), Tourette's syndrome, Tremor (e.g., essential tremor, resting tremor), Wilson disease (inherited disorder that causes neurological and psychiatric symptoms and liver disease). These excessive or otherwise abnormal involuntary movements may vary significantly in rate, frequency, periodicity and progression character. Parkinson's disease is a progressive disorder of the nervous system that affects about 10 million people world-wide and is of increasing occurrence in aging populations. It is a highly specific degeneration of dopamine-containing cells of the substantia nigra of the midbrain causing a dopamine deficiency in the striatum. It affects neurons in the part of the brain that controls muscle movement and causes symptoms such as trembling, muscle rigidity, difficulty in walking, and problems with balance and coordination. Further, Restless Leg Syndrome (RLS), also known as Ekbom's Syndrome a fairly common sensorimotor disorder, characterized in that it typically gives the individual who suffers from RLS an unpleasant sensation in the legs at rest, causing what is often described as an irresistible desire to move, leading to significant discomfort. Movement disorders like restless leg syndrome and periodic limb movement during sleep are common in patients with fibromyalgia and chronic fatigue syndrome. Fibromyalgia is a chronic pain disorder characterized by widespread musculoskeletal aches, pain and stiffness, soft tissue tenderness, general fatigue, and sleep disturbances. Fibromyalgia patients experience a range of symptoms of varying intensities that wax and wane over time. Chronic fatigue syndrome is a disorder that causes extreme fatigue that lasts longer with symptoms that include widespread muscle and joint pain, cognitive difficulties, chronic, often severe mental and physical exhaustion. Such type of movement disorders and impairments further complicate the administration of medication to the elderly population. Most commonly employed solid pharmaceutical preparations such as tablets or capsules are not suitable for this population as they may have difficulty in swallowing them. With liquid dosage forms, administration and stability of the drug and the dosage form can be a major concern. An ideal solid dosage form for these patients includes a formulation that simply melts in the mouth without any extra effort. Further, taste is an important parameter governing the compliance of patients of any age group. With unpleasant tasting drugs, the disagreeable taste of the drug can lead to low patient compliance. Such reduced compliance, especially in case of Parkinson's patients can lead to severe complications. Hence there exists a need to design taste-masked solid dosage forms of unpleasant tasting drugs for patients suffering from Parkinson's disease that dissolves or disintegrates in the oral cavity without the need for water providing a more convenient dosage form encouraging adherence to the daily medication regimen. Ropinirole, 4-[2-(dipropylamino)ethyl]-l,3-dihydro-2H-indol 2-one, used commonly as hydrochloride salt, is a selective non-ergoline dopamine agonist used mainly in the treatment of Parkinson's disease. Dopamine agonists function by increasing the dopamine levels in the brain. This helps to lessen the symptoms of Parkinson's disease. Ropinirole has also been disclosed as being of potential use in the treatment of a variety of other conditions, such as fibromyalgia (U.S. Patent No. 6,277,875), and chronic fatigue syndrome (U.S. Patent No. 6,300,365). Ropinirole is rapidly absorbed after oral administration, reaching peak concentration in approximately 1-2 hours. Treatment with ropinirole is- also desirable in pediatric patients suffering from Restless Leg Syndrome (RLS) and Attention Deficit Hyperactivity Disorder (ADHD), and study shows that it resulted in significant improvement (Reference: Ropinirole in a Child With Attention- Deficit Hyperactivity Disorder and Restless Legs Syndrome. Pediatric Neurology, Volume 32, Issue 5, Pages 350-351 E. Konofal, I. Arnulf, M. Lecendreux, M. Mouren). Such pediatric
Load more

Recommended publications
  • Xenoport Hurt by Solzira NDA Withdrawal
    November 11, 2008 Xenoport hurt by Solzira NDA withdrawal Evaluate Vantage News that Xenoport and partner GlaxoSmithKline’s recent application for restless legs syndrome (RLS) drug Solzira will have to be withdrawn, with the FDA requesting that data from a single trial be re-formatted, caused Xenoport’s shares to fall 13% yesterday to a new 18-month low of $34.44. With a potential 4-6 month delay to approval and the postponement of a $23m milestone that Xenoport was due to receive from Glaxo on the FDA’s acceptance of Solzira’s NDA, senior executives at the specialty US company could be forgiven for feeling somewhat aggrieved with Glaxo for this apparent oversight, given the pharma giant’s supposed experience and expertise in regulatory filings. The setback to Solzira and resulting slump in Xenoport’s share price suggests that shareholders who have not fled the stock will be even more desperate for positive phase IIb data for GERD treatment, XP19986 (Event - XenoPort looking for end of year trial lift, October 10, 2008). Formatting issues Avoiding these kinds of regulatory pitfalls, after all the cost and hard work involved in taking a drug through clinical development, is becoming an increasingly important factor behind a company’s decision to sign up a big pharma partner in today’s tougher regulatory environment. Both companies were naturally keen to stress that the NDA withdrawal has nothing to do with the content of the filing, which probably makes the rejection on a technicality all the more frustrating for Xenoport. Whilst the FDA requested the data from one particular study to be re-formatted, Glaxo has decided to review the formatting of other data sets in the application, presumably to ensure there can be no further grounds for rejection.
    [Show full text]
  • PHARMACEUTICAL APPENDIX to the TARIFF SCHEDULE 2 Table 1
    Harmonized Tariff Schedule of the United States (2020) Revision 19 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2020) Revision 19 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names INN which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service CAS registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known.
    [Show full text]
  • Stems for Nonproprietary Drug Names
    USAN STEM LIST STEM DEFINITION EXAMPLES -abine (see -arabine, -citabine) -ac anti-inflammatory agents (acetic acid derivatives) bromfenac dexpemedolac -acetam (see -racetam) -adol or analgesics (mixed opiate receptor agonists/ tazadolene -adol- antagonists) spiradolene levonantradol -adox antibacterials (quinoline dioxide derivatives) carbadox -afenone antiarrhythmics (propafenone derivatives) alprafenone diprafenonex -afil PDE5 inhibitors tadalafil -aj- antiarrhythmics (ajmaline derivatives) lorajmine -aldrate antacid aluminum salts magaldrate -algron alpha1 - and alpha2 - adrenoreceptor agonists dabuzalgron -alol combined alpha and beta blockers labetalol medroxalol -amidis antimyloidotics tafamidis -amivir (see -vir) -ampa ionotropic non-NMDA glutamate receptors (AMPA and/or KA receptors) subgroup: -ampanel antagonists becampanel -ampator modulators forampator -anib angiogenesis inhibitors pegaptanib cediranib 1 subgroup: -siranib siRNA bevasiranib -andr- androgens nandrolone -anserin serotonin 5-HT2 receptor antagonists altanserin tropanserin adatanserin -antel anthelmintics (undefined group) carbantel subgroup: -quantel 2-deoxoparaherquamide A derivatives derquantel -antrone antineoplastics; anthraquinone derivatives pixantrone -apsel P-selectin antagonists torapsel -arabine antineoplastics (arabinofuranosyl derivatives) fazarabine fludarabine aril-, -aril, -aril- antiviral (arildone derivatives) pleconaril arildone fosarilate -arit antirheumatics (lobenzarit type) lobenzarit clobuzarit -arol anticoagulants (dicumarol type) dicumarol
    [Show full text]
  • Serotonin Dopamine Antagonists)
    NewNew DevelopmentsDevelopments inin thethe ResearchResearch andand TreatmentTreatment ofof SchizophreniaSchizophrenia StephenStephen M.M. Stahl,Stahl, MD,MD, PhDPhD Adjunct Professor, Department of Psychiatry, University of California, San Diego School of Medicine Sponsored by Neuroscience Education Institute Additionally sponsored by American Society for the Advancement of Pharmacotherapy This activity is supported by educational grants from AstraZeneca Pharmaceuticals LP; Cephalon, Inc.; and Shire Pharmaceuticals Inc. with additional support from Alkermes, Inc.; Eli Lilly and Company; Jazz Pharmaceuticals, Inc.; and Sepracor Inc. Copyright © 2007 Neuroscience Education Institute. All rights reserved. Learning Objectives After completion of this lecture you should be able to: • Evaluate evidence about the function and efficacy of the newest antipsychotics • Describe the rationale and present state of pharmacogenetics research • Discuss goals and challenges of pharmacogenetics in psychiatry Copyright © 2008 Neuroscience Education Institute. All rights reserved. Overview: Four Bedtime Stories • A Tale of Serotonin Antagonism • The Dopamine Partial Agonism Story • Pharmacogenetics and the Genes • Once Upon a Glutamate Receptor Copyright © 2008 Neuroscience Education Institute. All rights reserved. Overview: Four Bedtime Stories • A Tale of Serotonin Antagonism • The Dopamine Partial Agonism Story • Pharmacogenetics and the Genes • Once Upon a Glutamate Receptor Copyright © 2008 Neuroscience Education Institute. All rights reserved. What
    [Show full text]
  • 2009 Paris, France the Movement Disorder Society’S 13Th International Congress of Parkinson’S Disease and Movement Disorders
    FINAL PROGRAM The Movement Disorder Society’s 13th International Congress OF PARKINSon’S DISEASE AND MOVEMENT DISORDERS JUNE 7-11, 2009 Paris, France The Movement Disorder Society’s 13th International Congress of Parkinson’s Disease and Movement Disorders Claiming CME Credit To claim CME credit for your participation in the MDS 13th International Congress of Parkinson’s Disease and Movement Disorders, International Congress participants must complete and submit an online CME Request Form. This Form will be available beginning June 10. Instructions for claiming credit: • After June 10, visit www.movementdisorders.org/congress/congress09/cme • Log in following the instructions on the page. You will need your International Congress Reference Number, located on the upper right of the Confirmation Sheet found in your registration packet. • Follow the on-screen instructions to claim CME Credit for the sessions you attended. • You may print your certificate from your home or office, or save it as a PDF for your records. Continuing Medical Education The Movement Disorder Society is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Credit Designation The Movement Disorder Society designates this educational activity for a maximum of 30.5 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity. Non-CME Certificates of Attendance were included with your on- site registration packet. If you did not receive one, please e-mail [email protected] to request one. The Movement Disorder Society has sought accreditation from the European Accreditation Council for Continuing Medical Education (EACCME) to provide the following CME activity for medical specialists.
    [Show full text]
  • The Use of Stems in the Selection of International Nonproprietary Names (INN) for Pharmaceutical Substances
    WHO/PSM/QSM/2006.3 The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances 2006 Programme on International Nonproprietary Names (INN) Quality Assurance and Safety: Medicines Medicines Policy and Standards The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances FORMER DOCUMENT NUMBER: WHO/PHARM S/NOM 15 © World Health Organization 2006 All rights reserved. Publications of the World Health Organization can be obtained from WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel.: +41 22 791 3264; fax: +41 22 791 4857; e-mail: [email protected]). Requests for permission to reproduce or translate WHO publications – whether for sale or for noncommercial distribution – should be addressed to WHO Press, at the above address (fax: +41 22 791 4806; e-mail: [email protected]). The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.
    [Show full text]
  • Downloaded from Survive Nursing | Survivenursing.Com V20110426
    Generic Stem Stem Definition Examples -abine (see -arabine, -citabine) decitabine -ac Anti-inflammatory agents (acetic acid derivatives) bromfenac; dexpemedolac -acetam See -racetam -actide Synthetic corticotropins seractide -adol or -aldol- Analgesics (mixed opiate receptor agonists/ antagonists) tazadolene; spiradolene; levonantradol -adox Antibacterials (quinoline dioxide derivatives) carbadox -afenone Antiarrhythmics (propafenone derivatives) alprafenone; diprafenone -afil PDE5 inhibitors tadalafil -aj- Antiarrhythmics (ajmaline derivatives) lorajmine -aldrate Antacid aluminum salts magaldrate -algron Alpha1 - and alpha2 - adrenoreceptor agonists dabuzalgron -alol Combined alpha and beta blockers labetalol; medroxalol -amivir (see -vir) -ampa Ionotropic non-NMDA glutamate receptors (AMPA and/or KA receptors) -ampanel Ionotropic non-NMDA glutamate receptors (AMPA and/or KA receptors) ; becampanel antagonists -ampator Ionotropic non-NMDA glutamate receptors (AMPA and/or KA receptors) ; forampator modulators -andr- Androgens nandrolone -anib Angiogenesis inhibitors semaxanib -anserin Serotonin 5-HT2 receptor antagonists altanserin; tropanserin; adatanserin -antel Anthelmintics (undefined group) carbantel -antrone Antineoplastics; anthraquinone derivatives pixantrone -apsel P-selectin antagonists torapsel -arabine Antineoplastics (arabinofuranosyl derivatives) fazarabine; fludarabine aril-, -aril, -aril- Antiviral (arildone derivatives) pleconaril; arildone; fosarilate -arit Antirheumatics (lobenzarit type) lobenzarit; clobuzarit -arol
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2016/0220580 A1 Rubin Et Al
    US 2016O220580A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2016/0220580 A1 Rubin et al. (43) Pub. Date: Aug. 4, 2016 (54) SMALL MOLECULESCREENING FOR (60) Provisional application No. 61/497,708, filed on Jun. MOUSE SATELLITE CELL PROLIFERATION 16, 2011. (71) Applicant: PRESIDENT AND FELLOWS OF Publication Classification HARVARD COLLEGE, Cambridge, (51) Int. Cl. MA (US) A 6LX3/553 (2006.01) (72) Inventors: Lee L. Rubin, Wellesley, MA (US); A613 L/496 (2006.01) Amanda Gee, Alexandria, VA (US); A613 L/4439 (2006.01) Amy J. Wagers, Cambridge, MA (US) A613 L/404 (2006.01) (52) U.S. Cl. CPC ............. A6 IK3I/553 (2013.01); A61 K3I/404 (21) Appl. No.: 15/012,656 (2013.01); A61 K3I/496 (2013.01); A61 K 31/4439 (2013.01) (22) Filed: Feb. 1, 2016 (57) ABSTRACT The invention provides methods for inducing, enhancing or Related U.S. Application Data increasing satellite cell proliferation, and an assay for screen (63) Continuation-in-part of application No. 14/126,716, ing for a candidate compound for inducing, enhancing or filed on Jun. 13, 2014, now Pat. No. 9.248,185, filed as increasing satellite cell proliferation. Also provided are meth application No. PCT/US2012/042964 on Jun. 18, ods for repairing or regenerating a damaged muscle tissue of 2012. a Subject. Patent Application Publication Aug. 4, 2016 Sheet 1 of 44 US 2016/0220580 A1 FIG. A Patent Application Publication Aug. 4, 2016 Sheet 2 of 44 US 2016/0220580 A1 FIG. C. FIG. 2A Patent Application Publication Aug.
    [Show full text]
  • Novel Therapeutic Strategies in Parkinson's Disease
    Novel therapeutic strategies in Parkinson’s disease Peter Klivenyi, Laszlo Vecsei To cite this version: Peter Klivenyi, Laszlo Vecsei. Novel therapeutic strategies in Parkinson’s disease. European Journal of Clinical Pharmacology, Springer Verlag, 2009, 66 (2), pp.119-125. 10.1007/s00228-009-0742-4. hal-00535002 HAL Id: hal-00535002 https://hal.archives-ouvertes.fr/hal-00535002 Submitted on 11 Nov 2010 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Eur J Clin Pharmacol (2010) 66:119–125 DOI 10.1007/s00228-009-0742-4 REVIEW ARTICLE Novel therapeutic strategies in Parkinson’s disease Peter Klivenyi & Laszlo Vecsei Received: 30 June 2009 /Accepted: 30 September 2009 /Published online: 16 October 2009 # Springer-Verlag 2009 Introduction producing symptomatic benefit. However, in the subse- quent human clinical trials, many of them failed to produce Parkinson’s disease (PD) is a neurodegenerative disorder the same efficacy as seen in preclinical studies. These characterized by resting tremor, rigidity, and bradykinesia. failures are not necessarily an indication of drug failure or The pathological processes begin years/decades before the drug action but may be related to inadequate administration, first motor symptoms are observed.
    [Show full text]
  • Wo 2007/075896 A2
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date PCT (10) International Publication Number 5 July 2007 (05.07.2007) WO 2007/075896 A2 (51) International Patent Classification: Arrow Rock Avenue, San Diego, CA 92126 (US). LUM, A61K 31/501 (2006.01) C07D 417/02 (2006.01) Christopher [US/US]; 13384 Bavarian Drive, San Diego, CA 92129 (US). ERNST, Justin [US/US]; 3535 Lebon (21) International Application Number: Drive #5105, San Diego, CA 92122 (US). PCT/US2006/048803 (74) Agents: CARSTEN, Douglas, H. et al; FOLEY & (22) International Filing Date: LARDNER LLP, P.O. Box 80278, San Diego, CA 20 December 2006 (20.12.2006) 92138-0278 (US). (25) Filing Language: English (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AT,AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, (26) Publication Language: English CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, (30) Priority Data: JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, 60/753,634 22 December 2005 (22.12.2005) US LT, LU, LV,LY,MA, MD, MG, MK, MN, MW, MX, MY, 60/787,362 30 March 2006 (30.03.2006) US MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, 60/842,051 1 September 2006 (01.09.2006) US RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW (71) Applicant (for all designated States except US): KEMIA, INC.
    [Show full text]
  • OMED 17 PHILADELPHIA, PENNSYLVANIA 29.5 Category 1-A CME Credits Anticipated
    ® OCTOBER 7 - 10 OMED 17 PHILADELPHIA, PENNSYLVANIA 29.5 Category 1-A CME credits anticipated ACOFP / AOA’s 122nd Annual Osteopathic Medical Conference & Exposition Joint Session with ACOFP and Cleveland Clinic: Managing Chronic Disease Parkinson's Disease: Early Warning Signs, When to Refer Hubert Fernandez, MD The American College of Osteopathic Family Physicians is accredited by the American Osteopathic Association Council to sponsor continuing medical education for osteopathic physicians. The American College of Osteopathic Family Physicians designates the lectures and workshops for Category 1-A credits on an hour-for-hour basis, pending approval by the AOA CCME, ACOFP is not responsible for the content. 10/5/2017 Early (and Late) Signs of PD: When to Refer Hubert H. Fernandez, MD, FAAN, FANA Professor of Medicine (Neurology) Cleveland Clinic Lerner College of Medicine Center Director Center for Neurological Restoration, Cleveland Clinic Disclosures Consulting: AbbVie, Acadia, Eli Lilly, Indus, Ipsen, Merz, Novartis, Pfizer, Sunovion, Voyager Independent Contractor (including contracted research): Acordia, Biogen, Kyowa Hakko, Michael J Fox Foundation, NIH/NINDS, Parkinson Study Group, Rhythm, Teva Teaching and Speaking: Medscape, Vindico Education 1 10/5/2017 Who gets PD? . Mean age of onset: 60-70, M>F . Affects 0.3% of the population and 1% of those older than 60 . Over 1.5 million people in North America affected Nutt JG and Wooten GF. New Engl J Med 2005;353(10): 1021-1027 PD Motor Symptoms 2 10/5/2017 The Parkinson Family Essential Tremor Progressive Drugs Multi- Vascular Supranuclear System Palsy Atrophy Idiopathic Toxins Parkinson’s Parkinson- Other Secondary Disease plus Encephalitis Lewy Cortico Body Basal Alzheimer’s Other Disease Degeneration Disease A Brief History of Our Understanding of PD 1917 2017 paralysis 1817 agitans Goetz CG.
    [Show full text]
  • Stembook 2018.Pdf
    The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances FORMER DOCUMENT NUMBER: WHO/PHARM S/NOM 15 WHO/EMP/RHT/TSN/2018.1 © World Health Organization 2018 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the same or equivalent Creative Commons licence. If you create a translation of this work, you should add the following disclaimer along with the suggested citation: “This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition”. Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of the World Intellectual Property Organization. Suggested citation. The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances. Geneva: World Health Organization; 2018 (WHO/EMP/RHT/TSN/2018.1). Licence: CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publication (CIP) data.
    [Show full text]