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Killer-Like Receptors and GPR56 Progressive Expression Defines Cytokine Production of Human CD4+ Memory T Cells
ARTICLE https://doi.org/10.1038/s41467-019-10018-1 OPEN Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4+ memory T cells Kim-Long Truong1,7, Stephan Schlickeiser1,2,7, Katrin Vogt1, David Boës1, Katarina Stanko1, Christine Appelt1, Mathias Streitz1, Gerald Grütz1,2, Nadja Stobutzki1, Christian Meisel1, Christina Iwert1, Stefan Tomiuk3, Julia K. Polansky2,4, Andreas Pascher5, Nina Babel2,6, Ulrik Stervbo 6, Igor Sauer 5, Undine Gerlach5 & Birgit Sawitzki1,2 1234567890():,; All memory T cells mount an accelerated response on antigen reencounter, but significant functional heterogeneity is present within the respective memory T-cell subsets as defined by CCR7 and CD45RA expression, thereby warranting further stratification. Here we show that several surface markers, including KLRB1, KLRG1, GPR56, and KLRF1, help define low, high, or exhausted cytokine producers within human peripheral and intrahepatic CD4+ memory T-cell populations. Highest simultaneous production of TNF and IFN-γ is observed in KLRB1+KLRG1+GPR56+ CD4 T cells. By contrast, KLRF1 expression is associated with T-cell exhaustion and reduced TNF/IFN-γ production. Lastly, TCRβ repertoire analysis and in vitro differentiation support a regulated, progressive expression for these markers during CD4+ memory T-cell differentiation. Our results thus help refine the classification of human memory T cells to provide insights on inflammatory disease progression and immunotherapy development. 1 Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 13353 Berlin, Germany. 2 Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité – Universitätsmedizin Berlin, 13353 Berlin, Germany. 3 Milteny Biotec GmbH, 51429 Bergisch Gladbach, Germany. -
December 2017.Pdf
MILITARY SEA SERVICES MUSEUM, INC. SEA SERVICES SCUTTLEBUTT December 2017 A message from the President Greetings, The year 2017 was another good year for the Museum. Thanks to our Member's dues, a substantial contribution from our most generous member and contributions from a couple of local patriotic organizations, we will end the year financially sound and feeling confident that we will be able to make any emergency repairs and continue to make improvements to the Museum. As reported in previous Scuttlebutts, most of our major projects have been completed. Our upgraded security system with motion activated cameras inside the Museum and outside the shed John Cecil should be completed this month. The construction of a concrete structure for the mid-1600s British Admiralty Cannon should be completed early next year. I hope everyone has a Merry Christmas and a New Year that is happy, healthy and prosperous. On this Christmas day let's all say a prayer for our troops that can't be home with families and loved ones. They are doing a great job of preventing the spread of terrorism and protecting our freedoms. Please say a prayer for their safe return home. John Military Sea Services entry in Sebring's 2017 Veteran's Day Parade The construction on Fred Carino's boat was done by Fred and his brother Chris. The replica of the bow ornament was done by Mary Anne Lamorte and her granddaughter Dominique Juliano. Military Sea Services Museum Hours of Operation 1402 Roseland Avenue, Sebring, Open: Thursday through Saturday Florida, 33870 Phone: (863) 385-0992 Noon to 4:00 p.m. -
Preliminary Program
Preliminary Program SPSA 2020 Annual Meeting San Juan, Puerto Rico v. 1.0 (10/21/19) 2100 2100 Indigeneity as a Political Concept Thursday Political Theory 8:00am-9:20am Chair Christopher M Brown, Georgia Southern University Participants Indigeneity as Social Construct and Political Tool Benjamin Gregg, University of Texas at Austin Policing the African State: Foreign Policy and the Fall of Self-Determination Hayley Elszasz, University of Virginia Discussant S. Mohsin Hashim, Muhlenberg College 2100 Historical Legacies of Race in Politics Thursday Race, Ethnicity, and Gender 8:00am-9:20am Chair Guillermo Caballero, Purdue University Participants Race and Southern Prohibition Movements Teresa Cosby, Furman University Brittany Arsiniega, Furman University Unintended Consequences?: The Politics of Marijuana Legalization in the United States and its Implications on Race Revathi Hines, Southern University and A&M College No Hablo Español: An Examination of Public Support of Increased Access to Medical Interpreters Kellee Kirkpatrick, Idaho State University James W Stoutenborough, Idaho State University Megan Kathryn Warnement, Idaho State University Andrew Joseph Wrobel, Idaho State University Superfluity and Symbolic Violence: Revisiting Hannah Arendt and the Negro Question in the Era of Mass Incarceration Gabriel Anderson, University of California, Irvine Weaponizing Culture and Women’s Rights: Indigenous Women’s Indian Status in Canada Denise M. Walsh, University of Virginia Discussant Andra Gillespie, Emory University The papers on this -
CPL-White-Paper-09-January-2013
London Metropolitan University: Centre for Progressive Leadership White Paper: Managing Leadership from a Systemic Perspective ISSUED JANUARY 2013 LONDON METROPOLITAN UNIVERSITY BUSINESS SCHOOL A CPL WHITE PAPER Managing Leadership from a Systemic Perspective Dr William Tate ABSTRACT How can an organisation best understand, expand, release, promote, improve, combine and apply leadership capability suited to its needs? The traditional model of individual leadership behaviour and development is no longer in tune with latest knowledge of the dynamics entailed in leadership performance in today’s complex environment. Development tools drawn from psychology insufficiently address the realities of organisational life. Understanding of the new sciences and the study of systems, combined with progressive 21stC social values, demand that a new perspective of leadership be taken, reflecting the holistic context in which leadership processes are now required to operate. This paper presents a systemic view of leadership, where the leadership role is one factor in an intricate system of interacting elements that affect how leadership is best applied in organisation settings and how it can be improved. The model challenges conventional approaches to the definition, specification and codification of leadership, as well as the way leadership is studied, how it is assessed and developed. Implications for various academic disciplines are considered, and a range of HR processes are discussed, including leadership development, accountability, coaching and performance management. THE VIEWS EXPRESSED IN THIS PAPER ARE THOSE OF THE AUTHOR AND DO NOT NECESSARILY REPRESENT THOSE OF LONDON METROPOLITAN UNIVERSITY BUSINESS SCHOOL OR THE CENTRE FOR PROGRESSIVE LEADERSHIP. © William Tate, The Institute for Systemic Leadership, 09 January 2013 1 London Metropolitan University: Centre for Progressive Leadership White Paper: Managing Leadership from a Systemic Perspective 1. -
Sunday Morning Grid 5/1/16 Latimes.Com/Tv Times
SUNDAY MORNING GRID 5/1/16 LATIMES.COM/TV TIMES 7 am 7:30 8 am 8:30 9 am 9:30 10 am 10:30 11 am 11:30 12 pm 12:30 2 CBS CBS News Sunday Face the Nation (N) Paid Program Boss Paid Program PGA Tour Golf 4 NBC News (N) Å Meet the Press (N) Å News Rescue Red Bull Signature Series (Taped) Å Hockey: Blues at Stars 5 CW News (N) Å News (N) Å In Touch Paid Program 7 ABC News (N) Å This Week News (N) NBA Basketball First Round: Teams TBA. (N) Basketball 9 KCAL News (N) Joel Osteen Schuller Pastor Mike Woodlands Amazing Paid Program 11 FOX In Touch Paid Fox News Sunday Midday Prerace NASCAR Racing Sprint Cup Series: GEICO 500. (N) 13 MyNet Paid Program A History of Violence (R) 18 KSCI Paid Hormones Church Faith Paid Program 22 KWHY Local Local Local Local Local Local Local Local Local Local Local Local 24 KVCR Landscapes Painting Joy of Paint Wyland’s Paint This Painting Kitchen Mexico Martha Pépin Baking Simply Ming 28 KCET Wunderkind 1001 Nights Bug Bites Space Edisons Biz Kid$ Celtic Thunder Legacy (TVG) Å Soulful Symphony 30 ION Jeremiah Youssef In Touch Leverage Å Leverage Å Leverage Å Leverage Å 34 KMEX Conexión En contacto Paid Program Fútbol Central (N) Fútbol Mexicano Primera División: Toluca vs Azul República Deportiva (N) 40 KTBN Walk in the Win Walk Prince Carpenter Schuller In Touch PowerPoint It Is Written Pathway Super Kelinda Jesse 46 KFTR Paid Program Formula One Racing Russian Grand Prix. -
Protein Identities in Evs Isolated from U87-MG GBM Cells As Determined by NG LC-MS/MS
Protein identities in EVs isolated from U87-MG GBM cells as determined by NG LC-MS/MS. No. Accession Description Σ Coverage Σ# Proteins Σ# Unique Peptides Σ# Peptides Σ# PSMs # AAs MW [kDa] calc. pI 1 A8MS94 Putative golgin subfamily A member 2-like protein 5 OS=Homo sapiens PE=5 SV=2 - [GG2L5_HUMAN] 100 1 1 7 88 110 12,03704523 5,681152344 2 P60660 Myosin light polypeptide 6 OS=Homo sapiens GN=MYL6 PE=1 SV=2 - [MYL6_HUMAN] 100 3 5 17 173 151 16,91913397 4,652832031 3 Q6ZYL4 General transcription factor IIH subunit 5 OS=Homo sapiens GN=GTF2H5 PE=1 SV=1 - [TF2H5_HUMAN] 98,59 1 1 4 13 71 8,048185945 4,652832031 4 P60709 Actin, cytoplasmic 1 OS=Homo sapiens GN=ACTB PE=1 SV=1 - [ACTB_HUMAN] 97,6 5 5 35 917 375 41,70973209 5,478027344 5 P13489 Ribonuclease inhibitor OS=Homo sapiens GN=RNH1 PE=1 SV=2 - [RINI_HUMAN] 96,75 1 12 37 173 461 49,94108966 4,817871094 6 P09382 Galectin-1 OS=Homo sapiens GN=LGALS1 PE=1 SV=2 - [LEG1_HUMAN] 96,3 1 7 14 283 135 14,70620005 5,503417969 7 P60174 Triosephosphate isomerase OS=Homo sapiens GN=TPI1 PE=1 SV=3 - [TPIS_HUMAN] 95,1 3 16 25 375 286 30,77169764 5,922363281 8 P04406 Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens GN=GAPDH PE=1 SV=3 - [G3P_HUMAN] 94,63 2 13 31 509 335 36,03039959 8,455566406 9 Q15185 Prostaglandin E synthase 3 OS=Homo sapiens GN=PTGES3 PE=1 SV=1 - [TEBP_HUMAN] 93,13 1 5 12 74 160 18,68541938 4,538574219 10 P09417 Dihydropteridine reductase OS=Homo sapiens GN=QDPR PE=1 SV=2 - [DHPR_HUMAN] 93,03 1 1 17 69 244 25,77302971 7,371582031 11 P01911 HLA class II histocompatibility antigen, -
Newsletter 09/07 DIGITAL EDITION Nr
ISSN 1610-2606 ISSN 1610-2606 newsletter 09/07 DIGITAL EDITION Nr. 206 - April 2007 Michael J. Fox Christopher Lloyd LASER HOTLINE - Inh. Dipl.-Ing. (FH) Wolfram Hannemann, MBKS - Talstr. 3 - 70825 K o r n t a l Fon: 0711-832188 - Fax: 0711-8380518 - E-Mail: [email protected] - Web: www.laserhotline.de Newsletter 09/07 (Nr. 206) April 2007 editorial Hallo Laserdisc- und DVD-Fans, und Fach. Wie versprochen gibt es dar- diesem Editorial auch gar nicht weiter liebe Filmfreunde! in unsere Reportage vom Widescreen aufhalten. Viel Spaß und bis zum näch- Es hat mal wieder ein paar Tage länger Weekend in Bradford. Also Lesestoff sten Mal! gedauert, aber nun haben wir Ausgabe satt. Und damit Sie auch gleich damit 206 unseres Newsletters unter Dach beginnen können, wollen wir Sie mit Ihr LASER HOTLINE Team LASER HOTLINE Seite 2 Newsletter 09/07 (Nr. 206) April 2007 US-Debüt der umtriebigen Pang-Brüder, die alle Register ihres Könnens ziehen, um im Stil von „Amityville Horror“ ein mit einem Fluch belegtes Haus zu Leben zu erwecken. Inhalt Roy und Denise Solomon ziehen mit ihrer Teenager-Tochter Jess und ihrem kleinen Sohn Ben in ein entlegenes Farmhaus in einem Sonnenblumenfeld in North Dakota. Dass sich dort womöglich übernatürliche Dinge abspielen könnten, bleibt von den Erwachsenen unbemerkt. Aber Ben und kurz darauf Jess spüren bald, dass nicht alles mit rechten Dingen zugeht. Weil ihr die Eltern nicht glauben wollen, recherchiert Jess auf eigene Faust und erfährt, dass sich in ihrem neuen Zuhause sechs Jahre zuvor ein bestialischer Mord abgespielt hat. Kritik Für sein amerikanisches Debüt hat sich das umtriebige Brüderpaar Danny und Oxide Pang („The Eye“) eine Variante von „Amityville Horror“ ausgesucht, um eine amerikanische Durchschnittsfamilie nach allen Regeln der Kunst mit übernatürlichem Terror zu überziehen. -
The Battle of Hampden and Its Aftermath
Maine History Volume 43 Article 3 Number 1 Here Come the British! 1-1-2007 The aB ttle of aH mpden and Its Aftermath Robert Fraser Follow this and additional works at: https://digitalcommons.library.umaine.edu/ mainehistoryjournal Part of the History Commons Recommended Citation Fraser, Robert. “The aB ttle of aH mpden and Its Aftermath” Maine History 43, no. 1 (January 2007): 21-40. This Article is brought to you for free and open access by DigitalCommons@UMaine. It has been accepted for inclusion in Maine History by an authorized administrator of DigitalCommons@UMaine. For more information, please contact [email protected]. THE BATTLE OF HAMPDEN AND ITS AFTERMATH BY ROBERT FRASER The successful British attack on the Penobscot Valley in fall 1814 was to annex eastern Maine to Canada, a move taken to protect the important line of communications between Halifax and Quebec. New England merchants had opposed the War of 1812, as it destroyed their interna- tional trade, and most New Englanders tried to remain neutral during the fray. At Hampden, enemy threats brought them out to defend their homes. Although Great Britain returned the area to the United States at war’s end, the occupation of the Penobscot Valley had lasting implica- tions for the District of Maine. Between 1954 and 1984 Robert Fraser was assistant curator at the Cohasset Historical Society and a consultant to other historical societies. He writes historical articles for local newspa- pers and national magazines, and has published two books on light- houses and another on local history. -
Supplementary Appendix
Supplementary Appendix This appendix has been provided by the authors to give readers additional information about their work. Supplement to: Gilbert PB, Montefiori DC, McDermott A, et al. Immune Correlates Analysis of the mRNA-1273 COVID-19 Vaccine Efficacy Trial 1 Table of Contents Immune Assays Team. ................................................................................................................................ 6 Moderna, Inc. Team. .................................................................................................................................. 6 Coronavirus Vaccine Prevention Network (CoVPN)/Coronavirus Efficacy (COVE) Team. .............. 7 CoVPN/COVE Team (cont’d): COVE Trial Investigators and Study Teams .................................... 10 United States Government (USG)/Coronavirus Prevention Network (CoVPN) Biostatistics Team. 20 Figure S1. Timing of mRNA-1273 doses, blood sampling, and the two time periods for diagnosis of COVID-19 endpoints (“Intercurrent” and “Post Day 57”). .................................................................. 21 Figure S2. Flowchart of study participants from enrollment to the case-cohort set of baseline SARS- CoV-2 negative per-protocol participants. ............................................................................................. 22 Supplementary Text 1: Additional details on the immunoassays ......................................................... 23 Solid-phase electrochemiluminescence S-binding IgG immunoassay (ECLIA) .................... -
Decoder Ring--Reprints and Refrigerators in "The American Comic Book (Critical Insights)" Jerry Spiller Art Institute of Charleston, [email protected]
Against the Grain Volume 27 | Issue 6 Article 43 2015 Decoder Ring--Reprints and Refrigerators in "The American Comic Book (Critical Insights)" Jerry Spiller Art Institute of Charleston, [email protected] Follow this and additional works at: https://docs.lib.purdue.edu/atg Part of the Library and Information Science Commons Recommended Citation Spiller, Jerry (2015) "Decoder Ring--Reprints and Refrigerators in "The American Comic Book (Critical Insights)"," Against the Grain: Vol. 27: Iss. 6, Article 43. DOI: https://doi.org/10.7771/2380-176X.7256 This document has been made available through Purdue e-Pubs, a service of the Purdue University Libraries. Please contact [email protected] for additional information. Decoder Ring — Reprints and Refrigerators in “The American Comic Book (Critical Insights)” Column Editor: Jerry Spiller (Art Institute of Charleston) <[email protected]> often lament that printed academic and schol- “Comic Fandom Through the Ages” sums up The essayists also note the lack of credit arly works lag behind online sources in time- changes in readership and the relationship and “larger than life” appeal afforded to even Iliness. To a degree, this is a simple necessity. between readers, creators, and the tone and positively portrayed female characters, as any I was pleasantly surprised in this regard subject matter and tone. The changes in both heroism or actual plot contributions they make when reading through the Salem Press volume fandom and creators detailed by Munson and are are often simply forgotten or overshadowed The American Comic Book, part of their Critical Helvie work well together to set up Katherine by the acts of male figures. -
Systems Thinking: from Heresy to Practice, Edited by A
Copyright material from www.palgraveconnect.com - licensed to npg - PalgraveConnect - 2015-03-15 - licensed to npg PalgraveConnect www.palgraveconnect.com material from Copyright 10.1057/9780230299221preview - Systems Thinking: From Heresy to Practice, Edited by A. Keivan Zokaei, John Seddon and Brendan O©Donovan Systems Thinking: From Heresy to Practice Copyright material from www.palgraveconnect.com - licensed to npg - PalgraveConnect - 2015-03-15 - licensed to npg PalgraveConnect www.palgraveconnect.com material from Copyright 10.1057/9780230299221preview - Systems Thinking: From Heresy to Practice, Edited by A. Keivan Zokaei, John Seddon and Brendan O©Donovan 9780230_285552_01_prexx.indd i 11/26/2010 9:58:29 AM Copyright material from www.palgraveconnect.com - licensed to npg - PalgraveConnect - 2015-03-15 - licensed to npg PalgraveConnect www.palgraveconnect.com material from Copyright 10.1057/9780230299221preview - Systems Thinking: From Heresy to Practice, Edited by A. Keivan Zokaei, John Seddon and Brendan O©Donovan 9780230_285552_01_prexx.indd ii 11/26/2010 9:58:29 AM Systems Thinking: From Heresy to Practice Public and Private Sector Studies Edited by Keivan Zokaei Consultant and Honorary Fellow at Warwick University John Seddon Consultant and Visiting Professor, Vanguard / Cardiff and Derby Universities and Brendan O’Donovan Copyright material from www.palgraveconnect.com - licensed to npg - PalgraveConnect - 2015-03-15 - licensed to npg PalgraveConnect www.palgraveconnect.com material from Copyright 10.1057/9780230299221preview - Systems Thinking: From Heresy to Practice, Edited by A. Keivan Zokaei, John Seddon and Brendan O©Donovan 9780230_285552_01_prexx.indd iii 11/26/2010 9:58:29 AM Selection and editorial content © Keivan Zokaei, John Seddon and Brendan O’Donovan 2011 Individual chapters © the contributors 2011 Foreword © Prof. -
Welcome to the Seventh Annual Hawaii International Conference on Education
2009 Hawaii International Conference on Education Honolulu, Hawaii Welcome to the Seventh Annual Hawaii International Conference on Education Aloha! We welcome you to the Seventh Annual Hawaii International Conference on Education. This event offers a rare opportunity for academics and other professionals from around the world to share their broad array of perspectives. True to its primary goal, this conference provides those with cross-disciplinary interests related to education to meet and interact with others inside and outside their own discipline. The international attendees to this conference bring a variety of viewpoints shaped by different cultures, languages, geography and politics. This diversity is also captured in the Hawaii International Conference’s unique cross-disciplinary approach. The resulting interaction energizes research as well as vocation. With Waikiki Beach, Diamond Head and the vast South Pacific as the backdrop, this venue is an important dimension of this conference. For centuries a stopping place of explorers, Hawaii has historically been enriched by the blend of ideas that have crossed our shores. The Hawaii International Conference on Education continues this tradition in the nurturing spirit of Aloha. Along with its ideal weather and striking beauty, the Hawaiian Islands provide natural elements to inspire learning and dialogue. The 2008 conference was a great success. We hosted more than 1,200 participants representing more than 40 countries. Thank you for joining the 2009 Hawaii International Conference on Education! The 2010 Hawaii International Conference on Education will be held January 7 – 10, 2010 at the Waikiki Beach Marriott Resort & Spa and the Hilton Waikiki Prince Kuhio Hotel in Honolulu, Hawaii.