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Chemical Biology and Molecular Biophysics Program (CBMB) in Drug Discovery and Biotechnology We look forward to seeing you on campus. ACADEMIA SINICA Taiwan International Graduate Program Chemical Biology and Molecular Biophysics Program (CBMB) in Drug Discovery and Biotechnology Introduction Under the leadership of previous directors, the Chemical Biology and Molecular Biophysics Program in Drug Discovery and Biotechnology – founded by TIGP, Academia Sinica in 2002 – has advanced to one of the best interdisciplinary programs in Taiwan. In the collaboration with leading universities in Taiwan: National Taiwan University and National Tsing Hua University, the program aims to enhance scholarly exchanges in order to benefit all parties on their overall research achievements and to increase the number of research professionals in the field in hopes of promoting the economic and social development of Taiwan. Over these years, the alumni and alumnae from CBMB have served in either academic institutions or biotech industry to contribute their expertise. The program is divided into two tracks: Chemical Biology (CB) track and Molecular Biophysics (MB) track. CB track collaborates with Department of Chemistry at NTU and NTHU while MB track collaborates with Institute of Biochemical Sciences and Department and Graduate Institute of Pharmacology at NTU and College of Life Science at NTHU. NTU and NTHU are the two top-ranked universities in Taiwan. The program lays a special emphasis on five research fields, including (1) protein chemistry, (2) structural biology, (3) medicinal and biological chemistry, (4) molecular and cell biology and (5) key technology. In addition to categorizing our faculty members and courses, this way reflects the necessary integration of multiple disciplines involved in today’s biotech development. The core courses offered by the program are Experimental Molecular Biophysics, Advanced Chemical Biology I and Advance Chemical Biology II. Through the training in courses, bench skills and thesis research, this program intends to offer students with two unique strengths: one is to become an independent researcher capable of solving problems and the other is to have the vision and ability to coordinate teamwork. CB MB Chemical Biology and Molecular Biophysics Program (CBMB) ACADEMIA SINICA Taiwan International Graduate Program in Drug Discovery and Biotechnology Faculty Members Academia Sinica Joseph Jen-Tse Huang automated carbohydrate synthesis; Ph.D., National Taiwan University, synthesis of glycoconjugates and study of Medicinal & Taiwan their interactions with envelop proteins of viruses Chemical Biology Protein misfolding and therapeutic strategy development in neuron Wen-Shan Li degenerative diseases; protein Ph.D., Case Western Reserve University, engineering and molecular probe design Chi-Huey Wong OH, USA Ph.D., Massachusetts Institute of Yun-Ru (Ruby) Chen Medicinal and bioorganic chemistry Technology, MA, USA Ph.D., North Carolina State Univ., NC, Bio-organic and synthetic organic Chung-Yi Wu USA chemistry Ph.D., National Chiao-Tung University, Protein folding and misfolding; amyloids Taiwan Ching-Shih Chen and amyloid in t er ac ting partners; diagnosis and therapeutic development We focus on the development of new Ph.D., Pharmaceutical Biochemistry, of neurodegenerative diseases especially and efficient methods to prepare the University of Wisconsin, USA Alzheimer’s disease important oligosaccharides and use sugar Drug design and discovery, cancer array to address their bio-function. biology, medicinal chemistry, signal An-Suei Yang transduction Jiun-Jie Shie Ph.D., the Johns Hopkins University, USA Ph.D., National Taiwan University, Chun-Hung Hans Lin Taiwan Antibody therapeutics and diagnostics Ph.D., the Scripps Research Institute, engineering and discovery; antibody Organic synthesis, chemical biology and CA, USA bioinformatics and phage-displayed drug discovery: We are interested in using Development of enzyme inhibitors for synthetic antibody library design organic chemistry as chemical tools to drug discovery; dissections of disease- study and address in biology related protein glycosylation and redox- Wei-Chieh Cheng modification Shang-Cheng Hung Ph.D., UC-Davis, USA Ph.D., Chemistry, National Tsing Hua Development of new chemical methods, Shih-Hsiung Wu University, Taiwan enzyme inhibitors, and small molecules Ph.D., School of Pharmacy, University of as chemical chaperones; investigation of Carbohydrate Synthesis, Glycotechnology, Wisconsin, Madison, WI, USA bacterial cell wall assembly and Glycobiology. Studies of structure-functional relationship of biomolecules including protein, Rong-Jie Chien peptide, polysaccharide, oligosaccharide, Ph.D., National Chiao-Tung University, polyketide and any small molecule Structural Biology Taiwan Hsiao-Ching Lin Development of new synthetic strategies and methods; total synthesis and the Ph.D., National Taiwan University, Shang-Te Danny Hsu study of the chemistry and biology of Taiwan (also specialized in Protein Chemistry) natural products and designed molecules Secondary metabolite biosynthesis, Ph.D., Utrecht University, the biocatalysts, drug discovery, natural Netherlands product chemistry Cheng-Chung Wang Molecular biophysics of functional dynamics and kinetics of proteins and Ph.D., TIGP-CBMB Program, Academia Yane-Shih Wang nucleic acids; folding mechanism of Sinica in cooperation with National Ph.D., Texas A&M University, USA topologically knotted proteins; solution Tsing Hua University Expanding genetic codes, protein state NMR spectroscopy Taiwan Development of new tools chemistry, protein polyhetero-Ub/SUMO and methodologies for carbohydrate modifications, biocatalysis and protein chemistry; development of new drug discovery technologies and methodologies for 2 3 Meng-Chiao Joseph Ho Chi-Yu Fu Lie-Fen Shyur (also specialised in Protein Chemistry) Ph.D., Biochemistry and Molecular Ph.D., National Taiwan University, Ph.D., Boston University, USA Genetics, University of Alabama at Taiwan Structural studies of protein complexes Birmingham, USA Creation and structure-function study involved in signal transduction and cancer Cryo-electron microscopy, electron of novel enzymes for bio industrial biology; protein engineer of industrial tomography and image analysis application; plant-derived drug enzymes; structure-based drug discovery development for inflammatory diseases Tsyr-Yan Dharma Yu Chung-I Chang (also specialised in Protein Chemistry) Carmay Lim Ph.D., University of Texas Southwestern Ph.D., Washington University in St. (also specialized in Structural Biology and Medical Center at Dallas, USA Louis, USA Medicinal & Chemical Biology) Structural biology, protein engineering, Membrane protein research and NMR Ph.D., University of Minnesota, structure-based drug discovery spectroscopy Minneapolis, USA Drug target identification and drug design Ming-Jing Hwang Jung-Hsin Lin using physical principles; development Ph.D., University of Pittsburgh, PA, USA Ph.D., University of Duisburg, Germany of methods for studying macromolecular Interested in all areas of computational Pharmacoinformatics; computational systems biology, especially those related to biophysics; bioinformatics; structural structural biology and post-genomics biology; molecular simulations Steve S.-F. Yu analysis. Ph.D., National Tsing Hua University, Hsinchu, Taiwan Metallo-enzymes and Su-Chang Lin Protein Chemistry bio-mimetics for catalytic conversions Ph.D., Life Sciences, National Defense of hydrocarbons; physiological roles of Medical Center, Taiwan To unravel iron-sulfur complexes in transcriptional factors from Prokaryotic systems the signaling mechanisms in immune Po-Huang Liang responses and cancer by structural and Chinpan Chen functional studies, and reconstitution of (also specialized in Medicinal & Chemical Biology) the signaling complexes (also specialized in Structural Biology) Ph.D., University of Maryland, MD, USA Ph.D., University of Washington, Hanna S. Yuan Kinetics, mechanisms, and inhibitors of Seattle, WA, USA Structural biology; Ph.D., University of Southern California, enzymes; anti-cancer drug discovery NMR; biophysics USA targeting protein-protein interactions; Structural and functional studies of RNA cellulose/hemicellulose degrading Che Alex Ma and DNA metabolism enzymes for biofuel production (also specialized in Structural Biology and Medicinal & Chemical Biology) Rita P.-Y. Chen Der-Lii M. Tzou Ph.D., University of Pennsylvania, USA Ph.D., Georgia Institute of Technology, Ph.D., University of Cambridge, UK Structure and function of membrane GA, USA Protein folding and misfolding; mechanism proteins in drug discovery Structural and functional analyses of and prevention of prion formation; vaccinia viral proteins and protein- therapy of Alzheimer’s disease Chwan-Deng Hsiao protein complexes; solid-state NMR (also specialized in Structural Biology) Tsung-Lin Li characterization of steroidal conformation Ph.D., University of Pittsburgh, PA, USA Ph.D., University of Cambridge, Structural and functional studies of Cambridge, UK protein-protein and protein- nucleic acids Natural products chemistry; drug interaction discovery; structural and mechanistic enzymology; synthetic biology 2 3 Chemical Biology and Molecular Biophysics Program (CBMB) ACADEMIA SINICA Taiwan International Graduate Program in Drug Discovery and Biotechnology Yu-Ju Chen Cell Biology Key Technology Ph.D., Iowa State University, IW, USA Analytical and physical chemistry; biochemical and biotechnological Ruey-Hwa Chen James C. Liao applications of mass spectrometry; Ph.D., Michigan
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