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Abstract Book II International Congress of Purinergic Signalling in South America Abstract book Maresias – São Paulo, Brazil May 30 to June 2, 2015 1 Presentation The Brazilian Purine Club was founded in 2009 with the objective of bringing together the scientific community interested in topics related to purinergic signaling. The organization of periodical congresses aims to promote the integration of researchers and students into a scientific field, which is rapidly expanding in Brazil and worldwide. Based on that, four scientific congresses were held so far. The “First Meeting of the Brazilian Purine Club: Purinergic signaling and therapeutic implications”, realized in August 2010 in Águas de Lindóia in São Paulo State, was attended by 150 participants (Researchers from Brazil and abroad in addition to a significant number of graduate and undergraduate students). The “Second Meeting of the Brazilian Purine Club” was realized in August 2011 in the city of Rio de Janeiro. The conference was attended by established researchers and students. These two initial meetings were organized as satellite symposiums of the annual conference of FESBE (Brazilian Federation of Experimental Biology Societies). The apparent success of the first two Brazilian Purine Club Meetings, demonstrated by the number of participants and increased scientific interactions between the members, encouraged us to organize a larger meeting in 2012. The “Third Meeting of the Brazilian Purine Club” was held in September in the town of Ouro Preto in the Minas Gerais State, followed in September 2013 by the “Fourth Meeting of the Brazilian Purine Club” in Canela, Rio Grande do Sul. The latter two congresses were organized and held independent from FESBE. Renowned scientists in the field of purinergic signaling from Brazil and abroad contributed to these meeting. More than 220 registrations were obtained. We count with your participation and contribution to “Fifth Meeting of the Brazilian Purine Club” to be held from May 30 – June 2, 2015 in the Beach hotel of Maresias (São Sebastião, State of São Paulo). The program of the meeting was put together based on suggestions of the members of the Purine Club. We believe that, as for the previous meetings, this congress will foster collaborative ties between Brazilian laboratories and laboratories around the world, working on purinergic signaling. Furthermore, we are confident that our initiative will contribute to the international insertion and recognition of the quality of Brazilian science, stimulate the exchange of ideas and promote collaborations with researchers from abroad. 2 Table of Content Presentation 2 Director and scientific council, Councilors and Organizing Committee 4 Program 5 Abstracts – Oral Sessions 11 Abstracts – Posters 101 Index of Authors 229 Sponsor’s Advertisements 231 3 DIRECTORSHIP AND SCIENTIFIC COUNCIL President: Prof. Dr. Henning Ulrich (USP) Vice-president: Prof. Dr. Robson Coutinho Silva (UFRJ) Secretary: Prof. Dr. Ana Lúcia Ventura (UFF) COUNCILORS Prof. Dr. Ana Maria Oliveira Battastini (UFRGS) Prof. Dr. Diogo Souza (UFRGS) Prof. Dr. Luis Carlos Crocco Afonso (UFOP) Prof. Dr. Maria Rosa Chitolina Schetinger (UFSM) Prof. Dr. Roberto Paes de Carvalho (UFF) ORGANIZING COMMITTEE Prof. Dr. Henning Ulrich (USP) Prof. Dr. Robson Coutinho Silva (UFRJ) Prof. Dr. Ana Lúcia Ventura (UFF) Prof. Dr. Zulma Ferreira (USP) Prof. Dr. Elizandra Braganhol (UFPel) Prof. Dr. Rodrigo Ribeiro Resende (UFMG) Prof. Dr. Claudiana Lameu (USP) Dr. Flávia Sarmento Vieira (USP) MSc Talita Glaser (USP) Prof. Dr. Juliana Fietto (UFV) Prof. Dr. Carla Inês Tasca (UFSC) Denise Yamamoto (USP) Zilda Mendonça Izzo (USP) 4 Program 30/05/2015 Saturday 14:00 -16:00 Registration 16:00 - 16:15 Opening Ceremony 16:15 – 17:00 Opening Conference Professor Geoffrey Burnstock, University College, London, UK Title: “Against the odds: a personal story” Chair: Henning Ulrich, University of São Paulo, Brazil 17:30 – 19:30 Welcome Reception and Poster Presentation Odd numbers 31/05/2015 Sunday 8:30 – 9:15 Guest Conference 1 Professor Maria Abbracchio, University degli Studi di Milan, Italy Title: “Purinergic regulation of adult central nervous system stem cells: is there a hope for novel neuro-reparative therapies?” Chair: Robson Coutinho Silva, Federal University of Rio de Janeiro, Brazil 9:15 – 9:30 Coffee Break 9:30 – 11:00 Symposium 1 (Room A) Symposium 2 (Room B) Purinergic signaling in immunity, stem and tumor cells Purinergic signaling in central nervous system Chair: Ana Maria Battastini, Federal University of Rio Chair: Roberto Paes de Carvalho, Fluminense Grande do Sul, Brazil Federal University, Niteroi, Brazil “Extracellular nucleotides and purinergic "Signaling pathways involved in the signaling as novel underappreciated pro- neuroprotective action of metastatic chemotactic factors for human lung guanosine" cancer cells” Carla Tasca, Federal University of Mariusz Ratajczak, University of Louisville, USA Santa Catarina, Brazil “Importance of P2X7 receptor for glioma “The role of P2 receptors in radiotherapy response” Parkinson’s disease” Fernanda B. Morrone, Catholic University of Rio Geanne Matos de Andrade, Federal Grande do Sul, Brazil University of Ceará, Brazil “Oncogenic pathways activated by P2X7 “Synapse-selective modulation of receptor” hippocampal GABAergic Elena Adinolfi, University of Ferrara, Italy transmission by adenosine” Ana Sebastião, University of Lisbon, “Adenosine uptake and activation of autophagy Portugal are the main effectors of extracellular ATP toxicity in human cervical cancer cells” “Role of adenosine A2A receptors in Guido Lenz, Federal University of Rio Grande do the control of mood-related Sul, Brazil neuropsychiatric diseases” Rodrigo Cunha, University of Coimbra, Portugal 5 11:10 – 12:40 Symposium 3 (Room A) Symposium 4 (Room B) Purinergic signaling in diseases Purinergic signaling in pathological conditions: Chair: Luiz Carlos Crocco Afonso UFOP, Brazil transporters and pores associated with purinergic signaling “Role of purinoceptor on malaria parasites Chair: Pedro Muanis Persechini. Biophysics development” Institute Carlos Chagas Filho – UFRJ, Brazil Célia Garcia, University of São Paulo, Brazil “Gliotransmission by ATP and its "Effect of purinergic receptors on infection by pathophysiological consequences” Chlamydia trachomatis" Schuichi Koizumi, University of David Ojcius, University of California, Merced, Yamanashi, Japan USA “RNAi-based strategy to study the “Pathological concentrations of homocysteine role of P2X7 receptor in the induce macrophages to a pro-inflammatory temporal lobe epilepsy” state by increasing IL1-B with the involvement Maria José Fernandes, Federal of P2X7 receptor” University of São Paulo, Brazil Rafael F. Zanin, La Salle Universitary Center, Canoas, Brazil “An extracellular network of purines, pyrimidines, and lipid mediators in “Polymorphisms in adenosine receptors and the immune-inflammatory system” major depressive disorder” Pedro M. Persechini, Federal Manuella Kaster, Federal University of Santa University of Rio de Janeiro, Brazil Catarina, Brazil "ATP release through pannexin channels" Gehard Dahl, University of Miami, USA 12:45 – 14:15 Lunch 14:30 – 15:15 Guest Conference 2 Professor Joel Linden, La Jolla Institute for Allergy and Immunology, San Diego, USA Title: “Targeting myelod adenosine receptors for tumor immunotherapy” Chair: Rodrigo Resende, Federal University of Minas Gerais, Brazil 15:15 – 15:30 Coffee Break 15:30 – 17:20 Symposium 5 (Room A) Symposium 6 (Room B) Purinergic signaling in context of parasite infection Challenges on crosstalk between academia Chair: Robson Coutinho Silva, Federal University of Rio de and industry on coffee research in Brazil Janeiro, Brazil Chair: Rui Daniel S. Prediger, Federal University of Santa Catarina, Brazil "Danger molecules ATP and adenosine signaling: at the crossroads of inflammation "The Brazilian Research looking for and pathogen persistence in the oral mucosa" the effects of coffee on health and Özlem Yilmaz, University of Florida, USA. diseases" Rui Prediger, Federal University of "The purinergic signaling in Trichomonas Santa Catarina, Brazil vaginalis-host interaction" Tiana Tasca, Federal University of Rio Grande do "The impact of regular coffee Sul, Brazil consumption on learning and memory and age-related cognitive “Bacterial RTX toxins allow acute ATP release deficits" from human erythrocytes directly through the Lisiane Porciúncula, Federal toxin pore” University of Rio Grande do Sul, Brazil Helle Praetorius, Aarhus University, Denmark 6 “Purinergic signaling contributes to " A2A receptor as a potential target schistosomiasis-related inflammation and in the control of dopamine-related endothelial dysfunction” function in the prefrontal cortex” Claudia Lucia Martins Silva, Federal University of Daniel Rial, Federal University of Rio de Janeiro, Brazil Santa Catarina, Florianópolis, Brazil. “P2X7 receptor signaling dives Th1 "The Programs of ABIC on Coffee effector/effector memory cell differentiation in Research" blood-stage Plasmodium chabaudi AS Malaria” Nathan Herszkowicz, Brazilian Maria Regina D’Império Lima, University of São Association of Coffee Industry, Brazil Paulo, Brazil "A personal experience of crosstalk between Academia and Industry on Coffee Research in Portugal" Rodrigo Cunha, University of Coimbra, Portugal 17:15 – 18:45 Coffee Break and Poster Presentation Even Numbers 19:00 – 20:30 Annual Meeting of the Brazilian Purine Club 20:30 Social Dinner 01/06/2015
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