Disease and Death in the Royal Navy's Western
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Evolution of Clinical Trials Throughout History
Evolution of clinical trials throughout history Emma M. Nellhaus1, Todd H. Davies, PhD1 Author Affiliations: 1. Office of Research and Graduate Education, Marshall University Joan C. Edwards School of Medicine, Huntington, West Virginia The authors have no financial disclosures to declare and no conflicts of interest to report. Corresponding Author: Todd H. Davies, PhD Director of Research Development and Translation Marshall University Joan C. Edwards School of Medicine Huntington, West Virginia Email: [email protected] Abstract The history of clinical research accounts for the high ethical, scientific, and regulatory standards represented in current practice. In this review, we aim to describe the advances that grew from failures and provide a comprehensive view of how the current gold standard of clinical practice was born. This discussion of the evolution of clinical trials considers the length of time and efforts that were made in order to designate the primary objective, which is providing improved care for our patients. A gradual, historic progression of scientific methods such as comparison of interventions, randomization, blinding, and placebos in clinical trials demonstrates how these techniques are collectively responsible for a continuous advancement of clinical care. Developments over the years have been ethical as well as clinical. The Belmont Report, which many investigators lack appreciation for due to time constraints, represents the pinnacle of ethical standards and was developed due to significant misconduct. Understanding the history of clinical research may help investigators value the responsibility of conducting human subjects’ research. Keywords Clinical Trials, Clinical Research, History, Belmont Report In modern medicine, the clinical trial is the gold standard and most dominant form of clinical research. -
Encountering Oceania: Bodies, Health and Disease, 1768-1846
Encountering Oceania: Bodies, Health and Disease, 1768-1846. Duncan James Robertson PhD University of York English July 2017 Duncan Robertson Encountering Oceania Abstract This thesis offers a critical re-evaluation of representations of bodies, health and disease across almost a century of European and North American colonial encounters in Oceania, from the late eighteenth-century voyages of James Cook and William Bligh, to the settlement of Australia, to the largely fictional prose of Herman Melville’s Typee. Guided by a contemporary and cross-disciplinary analytical framework, it assesses a variety of media including exploratory journals, print culture, and imaginative prose to trace a narrative trajectory of Oceania from a site which offered salvation to sickly sailors to one which threatened prospective settlers with disease. This research offers new contributions to Pacific studies and medical history by examining how late-eighteenth and early-nineteenth century concepts of health and disease challenged, shaped and undermined colonial expansion in Oceania from 1768-1846. In particular, it aims to reassess the relationship between contemporary thinking on bodies, health and disease, and the process of colonial exploration and settlement in the period studied. It argues that this relationship was less schematic than some earlier scholarship has allowed, and adopts narrative medical humanities approaches to consider how disease and ill-health was perceived from individual as well as institutional perspectives. Finally, this thesis analyses representations of bodies, health and disease in the period from 1768-1846 in two ways. First, by tracing the passage of disease from ship to shore and second, by assessing the legacy of James Cook’s three Pacific voyages on subsequent phases of exploration and settlement in Oceania. -
The Royal Hospital Haslar: from Lind to the 21St Century
36 General History The Royal Hospital Haslar: from Lind to the 21st century E Birbeck In 1753, the year his Treatise of the Scurvy was published (1,2), The original hospital plans included a chapel within the James Lind was invited to become the Chief Physician of the main hospital, which was to have been sited in the fourth Royal Hospital Haslar, then only partially built. However, he side of the quadrangular building. Due to over-expenditure, declined the offer and George Cuthbert took the post. this part of the hospital was never built. St. Luke’s Church A few years later the invitation to Lind was repeated. On was eventually built facing the quadrangle. Construction of this occasion Lind accepted, and took up the appointment the main hospital building eventually stopped in 1762. in 1758. In a letter sent that year to Sir Alexander Dick, a friend who was President of the Royal College of Physicians Early administration of Haslar Edinburgh, Lind referred to Haslar hospital as ‘an immense Responsibility for the day to day running of the hospital lay pile of building & … will certainly be the largest hospital in with Mr Richard Porter, the Surgeon and Agent for Gosport Europe when finished…’ (3). The year after his appointment, (a physician who was paid by the Admiralty to review and reflecting his observations on the treatment of scurvy, Lind care for sailors of the Fleet for a stipend from the Admiralty), is reputed to have advised Sir Edward Hawke, who was who had had to cope with almost insurmountable problems. -
Canada Archives Canada Published Heritage Direction Du Branch Patrimoine De I'edition
North Atlantic Press Gangs: Impressment and Naval-Civilian Relations in Nova Scotia and Newfoundland, 1749-1815 by Keith Mercer Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Dalhousie University Halifax, Nova Scotia August 2008 © Copyright by Keith Mercer, 2008 Library and Bibliotheque et 1*1 Archives Canada Archives Canada Published Heritage Direction du Branch Patrimoine de I'edition 395 Wellington Street 395, rue Wellington Ottawa ON K1A0N4 Ottawa ON K1A0N4 Canada Canada Your file Votre reference ISBN: 978-0-494-43931-9 Our file Notre reference ISBN: 978-0-494-43931-9 NOTICE: AVIS: The author has granted a non L'auteur a accorde une licence non exclusive exclusive license allowing Library permettant a la Bibliotheque et Archives and Archives Canada to reproduce, Canada de reproduire, publier, archiver, publish, archive, preserve, conserve, sauvegarder, conserver, transmettre au public communicate to the public by par telecommunication ou par Plntemet, prefer, telecommunication or on the Internet, distribuer et vendre des theses partout dans loan, distribute and sell theses le monde, a des fins commerciales ou autres, worldwide, for commercial or non sur support microforme, papier, electronique commercial purposes, in microform, et/ou autres formats. paper, electronic and/or any other formats. The author retains copyright L'auteur conserve la propriete du droit d'auteur ownership and moral rights in et des droits moraux qui protege cette these. this thesis. Neither the thesis Ni la these ni des extraits substantiels de nor substantial extracts from it celle-ci ne doivent etre imprimes ou autrement may be printed or otherwise reproduits sans son autorisation. -
Founding Fellows
Founding Members of the Royal Society of Edinburgh Alexander Abercromby, Lord Abercromby William Alexander John Amyatt James Anderson John Anderson Thomas Anderson Archibald Arthur William Macleod Bannatyne, formerly Macleod, Lord Bannatyne William Barron (or Baron) James Beattie Giovanni Battista Beccaria Benjamin Bell of Hunthill Joseph Black Hugh Blair James Hunter Blair (until 1777, Hunter), Robert Blair, Lord Avontoun Gilbert Blane of Blanefield Auguste Denis Fougeroux de Bondaroy Ebenezer Brownrigg John Bruce of Grangehill and Falkland Robert Bruce of Kennet, Lord Kennet Patrick Brydone James Byres of Tonley George Campbell John Fletcher- Campbell (until 1779 Fletcher) John Campbell of Stonefield, Lord Stonefield Ilay Campbell, Lord Succoth Petrus Camper Giovanni Battista Carburi Alexander Carlyle John Chalmers William Chalmers John Clerk of Eldin John Clerk of Pennycuik John Cook of Newburn Patrick Copland William Craig, Lord Craig Lorentz Florenz Frederick Von Crell Andrew Crosbie of Holm Henry Cullen William Cullen Robert Cullen, Lord Cullen Alexander Cumming Patrick Cumming (Cumin) John Dalrymple of Cousland and Cranstoun, or Dalrymple Hamilton MacGill Andrew Dalzel (Dalziel) John Davidson of Stewartfield and Haltree Alexander Dick of Prestonfield Alexander Donaldson James Dunbar Andrew Duncan Robert Dundas of Arniston Robert Dundas, Lord Arniston Henry Dundas, Viscount Melville James Edgar James Edmonstone of Newton David Erskine Adam Ferguson James Ferguson of Pitfour Adam Fergusson of Kilkerran George Fergusson, Lord Hermand -
Sailors' Scurvy Before and After James Lind – a Reassessment
Historical Perspective Sailors' scurvy before and after James Lind–areassessment Jeremy Hugh Baron Scurvy is a thousand-year-old stereotypical disease characterized by apathy, weakness, easy bruising with tiny or large skin hemorrhages, friable bleeding gums, and swollen legs. Untreated patients may die. In the last five centuries sailors and some ships' doctors used oranges and lemons to cure and prevent scurvy, yet university-trained European physicians with no experience of either the disease or its cure by citrus fruits persisted in reviews of the extensive but conflicting literature. In the 20th century scurvy was shown to be due to a deficiency of the essential food factor ascorbic acid. This vitamin C was synthesized, and in adequate quantities it completely prevents and completely cures the disease, which is now rare. The protagonist of this medical history was James Lind. His report of a prospective controlled therapeutic trial in 1747 preceded by a half-century the British Navy's prevention and cure of scurvy by citrus fruits. After lime-juice was unwittingly substituted for lemon juice in about 1860, the disease returned, especially among sailors on polar explorations. In recent decades revisionist historians have challenged normative accounts, including that of scurvy, and the historicity of Lind's trial. It is therefore timely to reassess systematically the strengths and weaknesses of the canonical saga.nure_205 315..332 © 2009 International Life Sciences Institute INTRODUCTION patients do not appear on the ship’s sick list, his choice of remedies was improper, and his inspissated juice was Long intercontinental voyages began in the late 16th useless.“Scurvy” was dismissed as a catch-all term, and its century and were associated with scurvy that seamen dis- morbidity and mortality were said to have been exagger- covered could be cured and prevented by oranges and ated. -
SHOVELL and the LONGITUDE How the Death of Crayford’S Famous Admiral Shaped the Modern World
SHOVELL AND THE LONGITUDE How the death of Crayford’s famous admiral shaped the modern world Written by Peter Daniel With Illustrations by Michael Foreman Contents 1 A Forgotten Hero 15 Ships Boy 21 South American Adventure 27 Midshipman Shovell 33 Fame at Tripoli 39 Captain 42 The Glorious Revolution 44 Gunnery on the Edgar 48 William of Orange and the Troubles of Northern Ireland 53 Cape Barfleur The Five Days Battle 19-23 May 1692 56 Shovell comes to Crayford 60 A Favourite of Queen Anne 65 Rear Admiral of England 67 The Wreck of the Association 74 Timeline: Sir Cloudsley Shovell 76 The Longitude Problem 78 The Lunar Distance Method 79 The Timekeeper Method 86 The Discovery of the Association Wreck 90 Education Activities 91 Writing a Newspaper Article 96 Design a Coat of Arms 99 Latitude & Longitude 102 Playwriting www.shovell1714.crayfordhistory.co.uk Introduction July 8th 2014 marks the tercentenary of the Longitude Act (1714) that established a prize for whoever could identify an accurate method for sailors to calculate their longitude. Crayford Town Archive thus have a wonderful opportunity to tell the story of Sir Cloudesley Shovell, Lord of the Manor of Crayford and Rear Admiral of England, whose death aboard his flagship Association in 1707 instigated this act. Shovell, of humble birth, entered the navy as a boy (1662) and came to national prominence in the wars against the Barbary pirates. Detested by Pepys, hated by James II, Shovell became the finest seaman of Queen Anne’s age. In 1695 he moved to Crayford after becoming the local M.P. -
James Lind’S 1753 Treatise of the Scurvy, an Extract of Which Is Reproduced in This Section
Public Health Classics This section looks back to some ground-breaking contributions to public health, adding a commentary on their significance from a modern-day perspective. To complement the theme of this month’s Bulletin, Iain Milne and Iain Chalmers comment on James Lind’s 1753 Treatise of the scurvy, an extract of which is reproduced in this section. Documenting the evidence: the case of scurvy Iain Milne1 & Iain Chalmers2 In 1753, James Lind, a Scottish naval surgeon and medical Although Lind is remembered for his controlled trial, graduate of Edinburgh University, published a 450-page, three- his account of it fills only four pages in the book: the rest of it part Treatise of the scurvy (1). At that time, scurvy was killing reports what had been published on the diagnosis, prognosis, thousands of people every year and was responsible for many prevention and treatment of scurvy. Lind’s systematic review more deaths of sailors in the Royal Navy than enemy action. of the literature deserves greater recognition, particularly now Believing that one of the reasons there was so much confusion that there is wide acceptance of the principle that decisions in about the diagnosis, prevention and cure of scurvy was that “no health care and health policy should be informed by up-to-date, physician conversant with this disease at sea had undertaken to systematic reviews of reliable, relevant research. throw light upon the subject”, Lind set about filling this gap, The year after Lind conducted his clinical experiment at with a clearly stated commitment to base his work on “observ- sea, he left the Navy and returned to Enlightenment Edinburgh, able facts” rather than on the theories that dominated medical where he graduated in medicine at the University, obtained a decision-making at that time. -
Ships' Boys and Youth Culture in Eighteenth-Century Britain: the Navy Recruits of the London Marine Society
Ships' Boys and Youth Culture in Eighteenth-Century Britain: The Navy Recruits of the London Marine Society Roland Pietsch Jim Hawkins, mousse et héro du roman de Robert L. Stevenson « L'île au trésor », est un personnage dont plusieurs d'entre nous aurons lu l'histoire dans notre jeunesse. Il est étonnant, cependant, qu'on ait fait si peu de recherches sur les vrais mousses du dix-huitième siècle. Fondé sur les archives de la London Marine Society, cet article tente de mettre au jour les origines et les motifs des garçons qui s'enrôlaient dans la Marine britannique au cours de la Guerre de sept ans contre la France. L'analyse suggère que le service en mer avait un double caractère pour les enfants des classes ouvrière et défavorisée : il leur fournissait une « demeure flottante », ce que n'arrivait pas à faire la communauté, et, en même temps, il semble qu'il offrait un moyen de s'enfuir pour les jeunes qui ne voulaient pas se conformer aux normes de la société. En recrutant ces derniers, mais aussi à cause de son environnement de travail, le marin acquérait plusieurs caractéristiques d'un modèle culturel pour la jeunesse. When thinking of ships' boys in the eighteenth century, the first that usually comes into one's mind is Jim Hawkins, the narrator in Robert L. Stevenson's Treasure Island. Yet, compared to such colourful stories of boys at sea in literature, historiography has little to offer on these juvenile sailors. Partly the lack of studies can be explained by the available source material: eighteenth-century records telling us about the boys aboard ships who were trained to become ordinary sailors are scarce. -
Faith@Work the Magazine of Glenrothes Baptist Church
faith@work the magazine of glenrothes baptist church march 2015 [1] Contents page THE PASTOR’S PAGES: LET US PRAY 1 HOLY WEEK SERVICES 8 BAPTISMS 9 FROM THE TREASURER 14 AN INTRODUCTION TO GBC 15 MISSION JAKARTA 18 SCOTTISH REFORMED CONFERENCE 26 ‘LORD, FOR THE YEARS’ 27 CONNECTED BY GRACE—JOHN THORNTON (2) 29 OUR ANNIVERSARY PREACHER 37 [2] The Pastor’s Pages LET US PRAY ur church is strong at many things. God Ohas given our church a heart to love and to reach out to others. We spend much time doing many great ministries and services to others within and without the church. We love the Word of God and proclaiming the gospel of Jesus Christ to the nations. We don’t shrink from proclaiming central doctrines, and ‘contending for the faith that was once for all delivered to the saints.’ We strive together to make disciples who make disciples. We seek to serve together using all of the different gifts of the body of the church, that Christ may be glorified. God is definitely at work among us. He is growing our church, and not only numerically. Souls are being saved, and all Christians (young & old) are growing in depth of insight and understanding in following Christ. However, I can’t help but think this is in spite of us— particularly when I consider our church’s heart for corporate prayer. Now, I’m not saying that we don’t pray. I’m sure as individuals and with friends we do pray a lot (I hope I’m not giving everyone the benefit of the doubt). -
Naval Accidents 1945-1988, Neptune Papers No. 3
-- Neptune Papers -- Neptune Paper No. 3: Naval Accidents 1945 - 1988 by William M. Arkin and Joshua Handler Greenpeace/Institute for Policy Studies Washington, D.C. June 1989 Neptune Paper No. 3: Naval Accidents 1945-1988 Table of Contents Introduction ................................................................................................................................... 1 Overview ........................................................................................................................................ 2 Nuclear Weapons Accidents......................................................................................................... 3 Nuclear Reactor Accidents ........................................................................................................... 7 Submarine Accidents .................................................................................................................... 9 Dangers of Routine Naval Operations....................................................................................... 12 Chronology of Naval Accidents: 1945 - 1988........................................................................... 16 Appendix A: Sources and Acknowledgements........................................................................ 73 Appendix B: U.S. Ship Type Abbreviations ............................................................................ 76 Table 1: Number of Ships by Type Involved in Accidents, 1945 - 1988................................ 78 Table 2: Naval Accidents by Type -
Rules and Regulations Proposed by the Board of Health for the Purpose
Digitized by tlie Internet Archive in 2014 littps://arcliive.org/details/b21354765 : RULES AND REGULATIONS PROPOSED BY THE SOAR]> OF HEAMH INTRODUCTION AI*D SPREADING FOR THK PURPOSE OF PREVENTING THE OF THE DISEASE CALLED CHOLERA MORBUS, to the observation Disease in its most marlied form, as it occurred The early symptoms of the and of Dr. Eussell and Dr. Barry at St. Petersburg, places where the Cholera has prevaUed, with corroborated by the accounts from other THE MOST APPROVED TREATMENT. Majesty's Privy Council Published by a Committee of the Lords of his TO WHICH ARE ADDED, A WARNING TO THE BRITISH PUBLIC AGAINST THE ALARMING APPROACH OF THE INDIAN CHOLERA. BY SIR GILBERT BLANE, Bart. F.R.S. AND THE HISTORY OF THE EPIDEMIC CHOLERA OF INDIA, FROM ITS FIRST APPEARANCE IN THE YEAR 1817, TO 1831, AND THE DREADFUL RAVAGES IT HAS COMMITTED, WITH THE DATES OP ITS FIRST APPEARANCE IN THE DIFFERENT PROVINCES. LONDON BURGESS AND HILL, 55, GREAT WINDMILL STREET, HAYMARKET. 1831. Price Sixpence, ^ ^^f > IMPORTANT WORK ON CHOLERA, Jttst Published, price \As, hoards. In one closely printed Volume 8vo., with a Map exhibiting the Progress of the Epidemic Cholera over the principal parts of India, by the dates of Its appcai ance at numerous places, with the Great Roads, &c. &c. AN ESSAY ON THE EPIDEMIC CHOLERA OF INDIA. BY REGINALD ORTON, Surgeon H. P. late of His Majesty's 3^th Regiment of Foot. CONTENTS. CHAP. I.-Description of Cholera, Sect, i, Of the Severer Form of Cholera, or the Common Form of the Epidemic.