DOCSLIB.ORG

Health Impacts and Environmental Footprints of Diets That Meet the Eatwell Guide Recommendations: Analyses of Multiple UK Studies

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Health Impacts and Environmental Footprints of Diets That Meet the Eatwell Guide Recommendations: Analyses of Multiple UK Studies Open access Original research BMJ Open: first published as 10.1136/bmjopen-2020-037554 on 26 August 2020. Downloaded from Health impacts and environmental footprints of diets that meet the Eatwell Guide recommendations: analyses of multiple UK studies Pauline Scheelbeek ,1,2 Rosemary Green,1,2 Keren Papier,3 Anika Knuppel,3 Carmelia Alae- Carew,2 Angela Balkwill,3 Timothy J Key,3 Valerie Beral,3 Alan D Dangour1,2 To cite: Scheelbeek P, ABSTRACT Strengths and limitations of this study Green R, Papier K, et al. Health Objectives To assess the health impacts and impacts and environmental environmental consequences of adherence to national ► This is the first study (in a UK context) using empir- footprints of diets that dietary recommendations (the Eatwell Guide (EWG)) in the meet the Eatwell Guide ical data to study health impacts and multiple envi- UK. recommendations: analyses of ronmental consequences of sustainable diets. Design and setting A secondary analysis of multiple multiple UK studies. BMJ Open ► The study uses multiple high- quality datasets with observational studies in the UK. 2020;10:e037554. doi:10.1136/ a total of 557 722 participants for health outcomes Participants Adults from the European Prospective bmjopen-2020-037554 and 5747 participants for environmental footprints. Investigation into Cancer - Oxford(EPIC- Oxford), UK Biobank ► The provided methods can be replicated in other ► Prepublication history and and Million Women Study, and adults and children aged 5 additional material for this settings and the Eatwell Guide dietary recommen- and over from the National Diet and Nutrition Survey (NDNS). paper are available online. To dations share many features of healthy lower envi- Primary and secondary outcome measures risk of total view these files, please visit ronmental impact diets. mortality from Cox proportional hazards regression the journal online (http:// dx. doi. ► Despite several sensitivity analyses, there might be models, total greenhouse gas emissions (GHGe) and org/ 10. 1136/ bmjopen- 2020- residual confounding (ie, unmeasured differences blue water footprint (WF) associated with ‘very low’ (0–2 037554). between people who eat different diets) distorting recommendations), ‘low’ (3–4 recommendations) or our findings. Received 12 February 2020 ‘intermediate- to- high’ (5–9 recommendations) adherence ► Although the evidence base and quality of methods http://bmjopen.bmj.com/ Revised 15 June 2020 to EWG recommendations. and metrics for environmental footprints are rap- Accepted 03 July 2020 Results Less than 0.1% of the NDNS sample adhere to idly improving, uncertainty about the exact mea- all nine EWG recommendations and 30.6% adhere to at surements of water footprints and greenhouse gas least five recommendations. Compared with ‘very low’ emissions of food items and diets in general remain. adherence to EWG recommendations, ‘intermediate- to- high adherence’ was associated with a reduced risk of mortality (risk ratio (RR): 0.93; 99% CI: 0.90 to 0.97) and −1.6 kg CO eq/day (95% CI: −1.5 to −1.8), or 30% lower 2 health and safeguarding environmental dietary GHGe. Dietary WFs were similar across EWG sustainability for future generations. Current on September 28, 2021 by guest. Protected copyright. adherence groups. Of the individual Eatwell guidelines, diets are associated with a high burden of © Author(s) (or their adherence to the recommendation on fruit and vegetable employer(s)) 2020. Re- use disease: globally ~1.9 billion adults are over- consumption was associated with the largest reduction in 1 permitted under CC BY. total mortality risk: an RR of 0.90 (99% CI: 0.88 to 0.93). weight or obese, 462 million are underweight Published by BMJ. Increased adherence to the recommendation on red and and over 30% of the world’s population suffers 1 2 Centre on Climate Change & processed meat consumption was associated with the from deficiencies of essential nutrients. The Planetary Health, London School largest decrease in environmental footprints (−1.48 kg of Hygiene & Tropical Medicine, food system that produces these diets is also CO eq/day, 95% CI: −1.79 to 1.18 for GHGe and −22.5 L/ London, United Kingdom 2 responsible for 21%–37% of global green- 3 2Department of Population day, 95% CI: −22.7 to 22.3 for blue WF). house gas emissions (GHGe) and agriculture Health, London School of Conclusions The health and environmental benefits of alone accounts for ~70% of fresh water with- Hygiene & Tropical Medicine, greater adherence to EWG recommendations support drawal.4 While food system GHGe contribute London, United Kingdom increased government efforts to encourage improved diets 3 to global climate change problems regard- Nuffield Department of in the UK that are essential for the health of people and the Population Health, Oxford planet in the Anthropocene. less of location of production, food system University, Oxford, UK water use is highly location specific: with approximately half of all countries classified Correspondence to BACKGROUND as ‘water scarce’—and a number of water safe Dr Pauline Scheelbeek; Diets are likely to play a crucial role in the countries projected to become water scarce Pauline. Scheelbeek@ lshtm. Anthropocene in supporting population ac. uk by 20405—origin of food supply is a crucial Scheelbeek P, et al. BMJ Open 2020;10:e037554. doi:10.1136/bmjopen-2020-037554 1 Open access BMJ Open: first published as 10.1136/bmjopen-2020-037554 on 26 August 2020. Downloaded from consideration when considering the sustainability of food these are subject to many assumptions related to the system water use. substitutions between food groups inherent to the dietary There is an urgent need for significant transformations change. To date, no study has been conducted using of the food system to produce diets that address both empirical dietary data (of large- scale cohort studies) to health and environmental concerns, and evidence on the assess ‘real- world’ composition of diets that are in adher- recommended composition of these diets is expanding ence with the EWG, which could substantially improve rapidly.6 7 While the specific composition of such diets has the uncertainty of estimation of the associated change in been shown to vary considerably culturally and region- dietary GHGe. Furthermore, to date, no analysis of the ally compared with existing consumption patterns, these WF of EWG adherence has been published. diets typically have substantially greater plant- based food In this report, we use high- quality data from three large content as well as no more than moderate content of prospective UK cohort studies to assess the health impacts animal sourced foods (eg, meat and dairy).6 8 9 associated with adherence to EWG dietary guidelines; The UK food system is no exception to these concerns and using nationally representative dietary intake data, for sustainability, and many transformative changes need we estimate the environmental footprints of UK diets with to be made to make it more sustainable, resilient and varying degrees of adherence to EGW recommendations. healthy. Currently 64% of the adult population in the UK are overweight or obese,10 and only 29% of adults and 18% of children between 5 and 15 years of age meet the METHODS recommended fruit and vegetable intake of ‘5 a day’.10 At Datasets the same time, water use of UK diets is on average 2757 L/ We used four high-quality data sources in this paper 11 capita/day, which is below the global average of 3167 L, (detailed description of each database provided in online but half of the national blue (surface and ground) water supplementary appendix 1). The databases from Euro- 3 footprint (WF)—15.0 million m /day—is imported (ie, pean Prospective Investigation into Cancer - Oxford embedded in imported foods from elsewhere) from (EPIC- Ox),26 UK Biobank (UKB)27 and the Million 12 13 countries with water scarcity. Furthermore, GHGe of Women Study (MWS)28 contain comprehensive health average UK diets were found to be 1210 kg CO2eq/capita/ information, linked death registration data as well as year as compared with an European Union average of dietary intake data. These three datasets were used to 14 1070 kg CO2eq/capita/year. Evidence suggests that 17% estimate the associations with health of adherence to of emissions could be avoided when the population were EWG recommendations. Details on the specific datasets 15 to shift to WHO dietary guidelines. have been published elsewhere. Briefly, participants in Governments are increasingly including both health the MWS were recruited from women invited for breast and environmental considerations in their recom- cancer screening in England and Scotland between 1996 mended dietary guidelines. In the UK, Public Health and 2001. Dietary intake was collected using semiquan- http://bmjopen.bmj.com/ England produced the ‘Eatwell Guide’ (EWG) as a titative questions and total mortality was determined ‘policy tool to define government recommendations on using death records. We used data from 464 078 partici- 16 eating healthily and achieving a balanced diet’. From pants of the MWS database. In the EPIC- Ox study, which a health perspective, the EWG promotes, for example, involves both male and female participants, dietary intake cereals, potatoes, fruit, vegetable and fibre consumption, was collected using a Food Frequency questionnaire, while recommending a limited consumption of sugar and while total mortality was ascertained using death record 17 processed meats. Adhering to these individual guide- linkage. We used data from 40 030 men and women of lines has been associated with several health benefits the EPIC- Ox database. For the UKB study, middle- aged on September 28, 2021 by guest. Protected copyright. 18 including improved cardiovascular health and reduced adults were recruited between 2006 and 2010. A subsa- 19 20 cancer risk. From an environmental perspective, the mple completed a minimum of three 24 hours dietary EWG mentions the importance of a ‘balance of healthier recall questionnaires.
Load more

Recommended publications
  • Million-Women-Study.Pdf
    ARTICLES Articles Breast cancer and hormone-replacement therapy in the Million Women Study Million Women Study Collaborators Summary Introduction Results from randomised controlled trials and from Background Current use of hormone-replacement therapy observational studies show that current and recent use of (HRT) increases the incidence of breast cancer. The Million hormone-replacement therapy (HRT) increases the risk of Women Study was set up to investigate the effects of breast cancer.1–4 However, the effect of HRT on mortality specific types of HRT on incident and fatal breast cancer. from breast cancer is unclear1–5 and use of HRT preparations containing oestrogen-progestagen combina- Methods 1 084 110 UK women aged 50–64 years were tions may be associated with a greater risk of breast cancer recruited into the Million Women Study between 1996 and than preparations containing oestrogen alone.6–10 The 2001, provided information about their use of HRT and other Million Women Study, a cohort study of a quarter of personal details, and were followed up for cancer incidence British women aged 50–64 years, was set up chiefly to and death. investigate the relation between various patterns of use of HRT and breast cancer incidence and mortality.11 Findings Half the women had used HRT; 9364 incident invasive breast cancers and 637 breast cancer deaths were Methods registered after an average of 2·6 and 4·1 years of follow-up, Data collection and definitions respectively. Current users of HRT at recruitment were more The National Health Service Breast Screening likely than never users to develop breast cancer (adjusted Programme (NHSBSP) invites all women in the UK aged relative risk 1·66 [95% CI 1·58–1·75], p<0·0001) and die 50–64 years for routine screening once every 3 years.
    [Show full text]
  • Drug Discovery
    DRUG DISCOVERY Edited by Hany A. El-Shemy Drug Discovery http://dx.doi.org/10.5772/3388 Edited by Hany A. El-Shemy Contributors Melanie A. Jordan, Lourdes Rodriguez-Fragoso, Irina Piatkov, Elizabeth Hong-Geller, Sonia Lobo-Planey, Pawel Kafarski, Gluza Karolina, Malemud, Jolanta Natalia Latosińska, Magdalena Latosińska, Terry Smith, Luis Jesús Villarreal- Gómez, Irma E. Soria-Mercado, Ana Leticia Iglesias, Graciela Lizeth Perez-Gonzalez, Carsten Wrenger, Eva Liebau, Taosheng Chen, Asli Nur Goktug, Sergio C. Chai, Xin Liang, Jimmy Cui, Jonathan Low, Henning Ulrich, Claudiana Lameu, Gabriel Magoma, Samuel Constant, Christophe Mas, Song Huang, Ludovic Wiszniewski Published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia Copyright © 2013 InTech All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book.
    [Show full text]
  • Disability and Participation in Breast and Bowel Cancer Screening in England: a Large Prospective Study
    SHORT COMMUNICATION British Journal of Cancer (2017) 117, 1711–1714 | doi: 10.1038/bjc.2017.331 Keywords: disability; screening; participation; bowel cancer; breast cancer Disability and participation in breast and bowel cancer screening in England: a large prospective study S Floud*,1, I Barnes1, M Verfu¨ rden2, H Kuper3, T Gathani1,4, R G Blanks1, R Alison1, J Patnick1, V Beral1, J Green1 and G K Reeves1 for the Million Women Study Collaborators5 1Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Roosevelt Drive, Oxford OX3 7LF, UK; 2UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK; 3International Centre for Evidence in Disability, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK and 4Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK Background: There is limited information about participation in organised population-wide screening programmes by people with disabilities. Methods: Data from the National Health Service routine screening programmes in England were linked to information on disability reported by the Million Women Study cohort participants. Results: Of the 473 185 women offered routine breast or bowel cancer screening, 23% reported some disability. Women with disabilities were less likely than other women to participate in breast cancer screening (RR ¼ 0.64, 95% CI: 0.62–0.65) and in bowel cancer screening (RR ¼ 0.75, 0.73–0.76). Difficulties with self-care or vision were associated with the greatest reduction in screening participation. Conclusion: Participation in routine cancer screening programmes in England is reduced in people with disabilities and participation varies by type of disability.
    [Show full text]
  • Download (806Kb)
    City Research Online City, University of London Institutional Repository Citation: Noble, R. ORCID: 0000-0002-8057-4252, Kaltz, O. and Hochberg, M. E. (2015). Peto's paradox and human cancers. Philosophical Transactions of the Royal Society B: Biological Sciences, 370(1673), 20150104.. doi: 10.1098/rstb.2015.0104 This is the accepted version of the paper. This version of the publication may differ from the final published version. Permanent repository link: https://openaccess.city.ac.uk/id/eprint/24709/ Link to published version: http://dx.doi.org/10.1098/rstb.2015.0104 Copyright: City Research Online aims to make research outputs of City, University of London available to a wider audience. Copyright and Moral Rights remain with the author(s) and/or copyright holders. URLs from City Research Online may be freely distributed and linked to. Reuse: Copies of full items can be used for personal research or study, educational, or not-for-profit purposes without prior permission or charge. Provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. City Research Online: http://openaccess.city.ac.uk/ [email protected] Submitted to Phil. Trans. R. Soc. B - Issue Peto's paradox and human cancers Journal: Philosophical Transactions B For ReviewManuscript ID: RSTB-2015-0104.R1 Only Article Type: Research Date Submitted by the Author: 26-Apr-2015 Complete List of Authors: Noble, Robert; University of Montpellier II, Institute
    [Show full text]
  • Oxford University Department of Statistics a Brief History John Gittins
    Oxford University Department of Statistics A Brief History John Gittins 1 Contents Preface 1 Genesis 2 LIDASE and its Successors 3 The Department of Biomathematics 4 Early Days of the Department of Statistics 5 Rapid Growth 6 Mathematical Genetics and Bioinformatics 7 Other Recent Developments 8 Research Assessment Exercises 9 Location 10 Administrative, Financial and Secretarial 11 Computing 12 Advisory Service 13 External Advisory Panel 14 Mathematics and Statistics BA and MMath 15 Actuarial Science and the Institute of Actuaries (IofA) 16 MSc in Applied Statistics 17 Doctoral Training Centres 18 Data Base 19 Past and Present Oxford Statistics Groups 20 Honours 2 Preface It has been a pleasure to compile this brief history. It is a story of great achievement which needed to be told, and current and past members of the department have kindly supplied the anecdotal material which gives it a human face. Much of this achievement has taken place since my retirement in 2005, and I apologise for the cursory treatment of this important period. It would be marvellous if someone with first-hand knowledge was moved to describe it properly. I should like to thank Steffen Lauritzen for entrusting me with this task, and all those whose contributions in various ways have made it possible. These have included Doug Altman, Nancy Amery, Shahzia Anjum, Peter Armitage, Simon Bailey, John Bithell, Jan Boylan, Charlotte Deane, Peter Donnelly, Gerald Draper, David Edwards, David Finney, Paul Griffiths, David Hendry, John Kingman, Alison Macfarlane, Jennie McKenzie, Gilean McVean, Madeline Mitchell, Rafael Perera, Anne Pope, Brian Ripley, Ruth Ripley, Christine Stone, Dominic Welsh, Matthias Winkel and Stephanie Wright.
    [Show full text]
  • Job Description and Person Specificationselection Criteria
    _________________________________________________________________________ Nuffield Department of Population Health Job description and selection criteria Personal Assistant to Prof Dame Valerie Beral, Co-Director of the Job title Cancer Epidemiology Unit Division Medical Sciences Division Department Nuffield Department of Population Health Unit Cancer Epidemiology Unit (CEU) Location Old Road Campus, Headington, Oxford Grade and salary Grade 5: £24,983 - £29,799 per annum Hours Full time (part time hours considered) Contract type Fixed term - 2 years Reporting to Prof Dame Valerie Beral, Co-Director of the Cancer Epidemiology Unit Vacancy reference 135188 Introduction Cancer Epidemiology Unit The main emphasis of research in the Cancer Epidemiology Unit (Director: Professor Valerie Beral) is on providing large-scale reliable evidence on the relationship between common exposures (such as obesity, diet, smoking, alcohol, the use of oral contraceptives and hormone replacement therapy) and common conditions of public health importance such as breast, prostate, and cervical cancers, cardiovascular disease and fractures. Much of this work centres on large scale cohort studies (the Million Women Study, EPIC, UK Biobank-Oxford), and on the several International Collaborative Groups based in the Unit. Current research areas also include work on statistical and epidemiological methodology, and a programme of work related to the National Health Service screening programmes for breast, cervical and bowel cancers. Since 2009 the Unit has also been conducting a programme of research into shift work, circadian rhythm disruption and cancer funded by the UK Health and Safety Executive. For more information please visit: http://www.ceu.ox.ac.uk Nuffield Department of Population Health The Nuffield Department of Population Health (NDPH) provides an excellent environment for multi-disciplinary research and teaching and in the 2014 REF (Research Excellence Framework) was ranked first for research in the area of public health, health services and primary care.
    [Show full text]
  • Mortality Risks of Oesophageal Cancer Associated with Hot Tea, Alcohol, Tobacco and Diet in Japan
    Journal of Epidemiology Vol. 8, No. 4 Oct Mortality Risks of Oesophageal Cancer Associated with Hot Tea, Alcohol, Tobacco and Diet in Japan Yoshihide Kinjo 1.2, Yadong Cui 3, Suminori Akiba 4, Shaw Watanabe 5, Naohito Yamaguchi 2, Tomotaka Sobue 2, Shoichi Mizuno 6, and Valerie Beral 1 To clarify mortality risks of oesophageal cancer associated with hot tea, alcohol, tobacco and diet, further analyses on the data from a large prospective cohort study in Japan were conducted. The subjects for analysis were 220,272 'men and women aged 40 to 69 at the baseline of 1965. There were 440 oesophageal cancer deaths during the period from January 1966 to December 1981. Person-years at risk were 3,065,182 in total. Rate ratio and 95% confidence interval adjusted for attained age, prefecture, occupation and sex were (RR (95%Cl)): 1.6 (1.2-2.0) for hot tea (drinking green tea at high temperatures) in comparison with not-hot tea (drinking green tea at moderate temperatures); 2.4 (1.8-3.1) for daily (4 times/week or more) alcohol drinking in comparison with non-drinking; and 2.3 (1.7-3.1) for heavy smoking (15 cigarettes/day or more) in comparison with non-smoking. Dose-response relationships were found in alcohol drinking and smoking among men and women (p for trend; p<0.001). The rate ratios were not significantly associated with the dietary factors except for green-yellow vegetables (1-3 times/month or less in comparison with daily; RR=2.0, 95%Cl: 1.2 -3.1), where a no dose-response trend was observed (p=0.45).
    [Show full text]
  • 10Th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies: Basic, Epidemiologic and Clinical Research National Cancer Institute
    10th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies: Basic, Epidemiologic and Clinical Research National Cancer Institute Presented by the Office of AIDS Malignancy Program and the Office of International Affairs October 16–17, 2006 Marriott Bethesda North Hotel and Conference Center, North Bethesda, Maryland U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health 10th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies: Basic, Epidemiologic and Clinical Research Presented by the Office of AIDS Malignancy Program and the Office of International Affairs October 16–17, 2006 Marriott Bethesda North Hotel and Conference Center North Bethesda, Maryland 10th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies Marriott Bethesda North Hotel & Conference Center, North Bethesda, Maryland October 16–17, 2006 TABLE OF CONTENTS Program .............................................................................................................................. 1 Continuing Medical Education................................................................................................ 7 Program Committee ............................................................................................................. 9 ACSR..................................................................................................................................11 Abstracts ............................................................................................................................13
    [Show full text]
  • Moderate Alcohol Intake and Cancer Incidence in Women Naomi E
    ARTICLE Moderate Alcohol Intake and Cancer Incidence in Women Naomi E. Allen , Valerie Beral , Delphine Casabonne , Sau Wan Kan , Gillian K. Reeves , Anna Brown , Jane Green ; on behalf of the Million Women Study Collaborators Background With the exception of breast cancer, little is known about the effect of moderate intakes of alcohol, or of particular types of alcohol, on cancer risk in women. Methods A total of 1 280 296 middle-aged women in the United Kingdom enrolled in the Million Women Study were routinely followed for incident cancer. Cox regression models were used to calculate adjusted relative risks and 95% confidence intervals (CIs) for 21 site-specific cancers according to amount and type of alco- holic beverage consumed. All statistical tests were two-sided. Results A quarter of the cohort reported drinking no alcohol; 98% of drinkers consumed fewer than 21 drinks per week, Downloaded from with drinkers consuming an average of 10 g alcohol (1 drink) per day. During an average 7.2 years of follow-up per woman 68 775 invasive cancers occurred. Increasing alcohol consumption was associated with increased risks of cancers of the oral cavity and pharynx (increase per 10 g/d = 29%, 95% CI = 14% to 45%, Ptrend < .001), esophagus (22%, 95% CI = 8% to 38%, Ptrend = .002), larynx (44%, 95% CI = 10% to 88%, Ptrend = .008), http://jnci.oxfordjournals.org/ rectum (10%, 95% CI = 2% to 18%, Ptrend = .02), liver (24%, 95% CI = 2% to 51%, Ptrend = .03), breast (12%, 95% CI = 9% to 14%, Ptrend < .001), and total cancer (6%, 95% CI = 4% to 7%, P trend < .001).
    [Show full text]
  • Wellcome Trust Grants Awarded 2014/15 1 October 2014–30 September 2015 Key to Panels (Column O)
    Wellcome Trust Grants Awarded 2014/15 1 October 2014–30 September 2015 Key to panels (column O) AAC Arts Awards Funding Committee AHI R&D for Affordable Healthcare in India APS Small Arts and People Awards BDA Broadcast Development Awards Committee BRM Biomedical Resources and Multi-user Equipment Committee BSI Basic Science Interview Committee CCA C&S Capital Awards Ctte 18/3/15 CLI Clinical Interview Committee DEL DELTAs (Developing Excellence in Leadership, Training and Science Initiative) EBO Ebola Trials Committee ENA Education & Neuroscience Award Ctte ER1 Genetics, Genomics and Population Research ER2 Cellular and Molecular Neuroscience ER3 Cognitive Neuroscience and Mental Health ER4 Immune System in Health and Disease ER5 Pathogen Biology and Disease Transmission ER6 Physiology in Health and Disease ER7 Cell and Developmental Biology ER8 Molecular Basis of Cell Function ER9 Population and Public Health ERE Ethics and Society ERM Medical History and Humanities GHT Global Health Trials Committee GOV Wellcome Governors H3A Human Heredity and Health in Africa HIF Health Innovation Challenge Fund Joint Funding Panel IDP Internal Decision Panel IPE International Engagement Funding Committee ISE Internal Small grants - Ethics&Soc ISM Internal Small grants - Med Hmnties MHS Seed Committee for MH PAG Pathfinders Assessment Group PHC Public Health and Tropical Medicine Interview Committee PHD PhD Studentships PUB Public Engagement RRH Research Resources in Medical History Funding Committee SAC Strategic Awards Committee SDD Seeding Drug
    [Show full text]
  • Dame Valerie Beral, DBE, AC, FRS Director, Cancer Epidemiology Unit, University of Oxford 161St Cutter Lecture the Causes of Breast Cancer May 6, 2015
    Epicenter Department of Epidemiology Newsletter Special Edition Dame Valerie Beral, DBE, AC, FRS Director, Cancer Epidemiology Unit, University of Oxford 161st Cutter Lecture The Causes of Breast Cancer May 6, 2015 Special Edition 161 st Cutter Lecture Lecturer: Dame Valerie Beral, DBE, AC, FRS Cutter Lecture on Preventative Medicine Since 1912, the Cutter Lecture on Preventive Medicine has been one of the most respected presentations, espe- cially in the field of epidemiology. The lectures are administered by the Department of Epidemiology at the Harvard T.H. Chan School of Public Health according to the bequest from John Clarence Cutter, MD (1851 - 1909), a graduate of the Harvard Medical School. He specified that the lectures be delivered in Boston, free of charge to medical professionals and the press. Covering a range of public health topics, the lectures remain dedicated to enhancing the physical and social welfare of the world’s population. The Causes of Breast Cancer Breast cancer is a prevalent disease in some of the world’s most prosperous na- tions. Nearly two million women worldwide will be diagnosed with breast cancer by 2030, according to the World Health Organization. That is double the rate of cases in 2000, and most of the increase will be in low- and middle-income devel- oping countries. Today, there is a significantly higher incidence of breast cancer (approximately 6 percent by age 70) among women who live in North America and Western Europe versus rural Africa and Asia (approximately 1 percent), but this socioeconomic disparity is showing signs of seismic shift. Evidence suggests the gap will narrow rapidly.
    [Show full text]
  • Anticancer Drug Discovery — from Serendipity to Rational Design
    Chapter 2 Anticancer Drug Discovery — From Serendipity to Rational Design Jolanta Natalia Latosińska and Magdalena Latosińska Additional information is available at the end of the chapter http://dx.doi.org/10.5772/52507 1. Introduction Cancer is nowadays used as a generic term describing a group of about 120 different diseases, which can affect any part of the body and defined as the state characterized by the uncontrolled growth and invasion of normal tissues and spread of cells [1]. According to WHO reports cancer is a leading cause of premature death worldwide, accounting for 7.6 million deaths (around 13% of all deaths) only in 2008 [2]. The deaths from cancer worldwide are projected to continue rising, reaching an estimated 13.1 million in 2030 (WHO 2012). The number of all cancer cases around the world reached 12.7 million in 2008 and is expected to increase to 21 million by 2030. Approximately one in five people before age 75 will suffer from cancer during their lifetime, while one in ten in this age range is predicted to die due to cancer [2]. About 70% of all cancer deaths occurred in low- and middle-income countries. Cancer statistics indicate that most common new cancer cases (excluding common non-melanoma skin cancer) include lung, breast, colorectum, stomach, prostate and liver. These statistics are affected by a few factors including the increase in the number of carcinogens in daily life conditions (food, alcohol, tobacco etc.; high levels of chemicals and pollutants in environment, exposure to UV and ionizing radiation and viruses), genetic disposition [1] but also higher effectiveness of the treatment regimes.
    [Show full text]