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10Th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies: Basic, Epidemiologic and Clinical Research National Cancer Institute 10th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies: Basic, Epidemiologic and Clinical Research National Cancer Institute Presented by the Office of AIDS Malignancy Program and the Office of International Affairs October 16–17, 2006 Marriott Bethesda North Hotel and Conference Center, North Bethesda, Maryland U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health 10th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies: Basic, Epidemiologic and Clinical Research Presented by the Office of AIDS Malignancy Program and the Office of International Affairs October 16–17, 2006 Marriott Bethesda North Hotel and Conference Center North Bethesda, Maryland 10th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies Marriott Bethesda North Hotel & Conference Center, North Bethesda, Maryland October 16–17, 2006 TABLE OF CONTENTS Program .............................................................................................................................. 1 Continuing Medical Education................................................................................................ 7 Program Committee ............................................................................................................. 9 ACSR..................................................................................................................................11 Abstracts ............................................................................................................................13 Author Index ......................................................................................................................89 List of Participants...............................................................................................................95 Assessment i 10th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies Marriott Bethesda North Hotel & Conference Center, North Bethesda, Maryland October 16–17, 2006 PROGRAM Monday, October 16 8:00 AM– 6:00 PM Poster Presentations 8:00 Opening Remarks and Welcome Kishor Bhatia, PhD, MRCPath National Cancer Institute, NIH, Bethesda, MD, USA 8:15 P1: Viral Malignancies and an International Perspective John Ziegler, MD, MSc University of California, San Francisco, Comprehensive Cancer Center, USA 9:00 AM– KSHV and Kaposi’s Sarcoma (KS) 10:00 AM Moderator: Denise Whitby, PhD 9:00 P2: Modulation of Cell Signaling and Angiogenesis by KSHV Blossom Damania, PhD University of North Carolina at Chapel Hill, USA 9:30 P3: AIDS-Associated Kaposi’s Sarcoma (KS) at 25: A Model for the Evaluation of Targeted Antiangiogenesis Therapy Susan Krown, MD Memorial Sloan-Kettering Cancer Center, New York, NY, USA 10:00 AM Break 10:20 AM– Session 1: Kaposi’s Sarcoma–Associated Herpesvirus (KSHV/HHV-8): 12:05 PM Pathogenesis of Disease and Pathogenesis-Based Therapy Moderators: Robert Yarchoan, MD, and Andrew Grulich, PhD 10:20 Activation of Kaposi’s Sarcoma–Associated Herpesvirus (KSHV) to Lytic Replication by the Cytotoxic Chemotherapy Drugs Vincristine and Doxorubicin Kazushi Nakano, MD, National Cancer Institute, Bethesda, MD, USA 10:35 Identification of Novel NFκΒ Inhibitors in Primary Effusion Lymphoma Cells Ethel Cesarman, MD, PhD, Weill Medical College of Cornell University, New York, NY, USA 10:50 Rapamycin is Efficacious against Primary Effusion Lymphoma (PEL) Dirk Dittmer, PhD, University of North Carolina at Chapel Hill, USA 11:05 Cyclooxygenase-2 (COX-2) Induced by KSHV Early During In Vitro Infection of Target Cells Plays a Role in the Maintenance of Latent Viral Gene Expression Neelam Sharma-Walla, PhD, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA 1 10th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies Marriott Bethesda North Hotel & Conference Center, North Bethesda, Maryland October 16–17, 2006 Session 1, continued 11:20 Intracellular KSHV Load Determines Early Loss of Immune Synapse Components Laura Adang, PhD, University of Virginia, Charlottesville, USA 11:35 HHV-8 Infects and Replicates in Primary Cultures of Activated B Lymphocytes Through DC-SIGN Giovanna Rappocciolo, PhD, University of Pittsburgh, PA, USA 11:50 KSHV-LANA Stabilizes c-Myc by Activating ERK1/2 and Inhibiting GSK-3 Jianyong Liu, MD, PhD, Johns Hopkins School of Medicine, Baltimore, MD, USA 12:05 PM Lunch 1:25 PM– Lymphoma and EBV as a Therapeutic Target 2:30 PM 1:25 Introductory Remarks Elliott Kieff, MD, PhD Harvard Medical School, Boston, MA, USA 1:30 P4: InterLymph: An International Collaboration on the Epidemiology of Non-Hodgkin Lymphoma Wendy Cozen, DO, MPH Keck School of Medicine, University of Southern California, Los Angeles, USA 2:00 P5: Pathogenesis of B Cell Lymphomas: Implications in the Context of AIDS Gianluca Gaidano, MD, PhD Amedeo Avogadro University of Eastern Piedmont, Novara, Italy 2:30 PM– Session 2: Lymphoma and Epstein-Barr Virus (EBV): New Insights and 3:15 PM Treatments Moderators: Kevin Howcroft, PhD, and Sam Mbulaiteye, MD 2:30 Elevated Activation-Induced Cytidine Deaminase (AID) Expression Preceding the Diagnosis of AIDS-Associated Burkitt’s Lymphoma Marta Epeldegui, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA 2:45 Development of a Therapeutic Vaccine for HIV-associated Hodgkin’s Lymphoma Rajiv Khanna, PhD, Queensland Institute of Medical Research, Brisbane, Australia 3:00 EBV Gene Transcription Kinetics During Viral Reactivation by Bortezomib in Cell Lines and in a Clinical Setting Rachel Bagni, MS, NCI-Frederick, MD, USA 3:15 PM Break 2 10th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies Marriott Bethesda North Hotel & Conference Center, North Bethesda, Maryland October 16–17, 2006 3:30 PM– Session 3: Clinical Management of AIDS-Associated Lymphoma 4:30 PM Moderator: Alexandra Levine, MD, and Richard Ambinder MD, PhD 3:30 Randomized Phase II Trial of Infusional EPOCH Chemotherapy Given Either Concurrently with or Sequentially Followed by Rituximab in HIV-Associated Lymphoma: AIDS Malignancy Consortium Trial 034 Joseph Sparano, MD, Montefiore-Einstein Cancer Center, Bronx, NY, USA 3:45 Abbreviated EPOCH-Rituximab Therapy with HAART Suspension Is Highly Effective and Tolerable in AIDS Related Lymphoma Kieron Dunleavy, MD, National Cancer Institute, Bethesda, MD, USA 4:00 Dose Modified Oral Chemotherapy for AIDS-Related Non-Hodgkin's Lymphoma (AR-NHL) in East Africa: Impact on CD4+ count and HIV-1 replication; and Retrospective Look at Similar Regimen In Pre-HAART Era in the USA Walter Mwanda, MBChB, MD, University of Nairobi College of Health Sciences and Kenyatta National Hospital–Case Research Collaboration, Kenya 4:15 Discussion 4:35 PM– Adjourn to Posters 6:00 PM Authors of AB#1–41 please stand by your poster. 3 10th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies Marriott Bethesda North Hotel & Conference Center, North Bethesda, Maryland October 16–17, 2006 Tuesday, October 17 8:00 AM– Poster Presentations 6:00 PM 8:10 Administrative Remarks Geraldina Dominguez, PhD 8:15 AM– HPV, Disease and Vaccine 10:15 AM Moderator: Joel Palefsky, MD, FRCP 8:15 P6: HPV Infection and Cancer in Normal and Immunologically Impaired Hosts Douglas Lowy, MD National Cancer Institute, NIH, Bethesda, MD, USA 8:45 P7: HPV Infection in HIV-Positive Women Silvia Franceschi, MD International Agency for Research on Cancer, Lyon, France 9:15 P8: HPV VLP Vaccine: Clinical Trial Results and Implementation Challenges Diane Harper, MD, MPH, MS Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, NH, USA 9:45 P9: Development of a Broadly Protective HPV Vaccine Based on L2 Richard Roden, PhD Johns Hopkins School of Medicine, Baltimore, MD, USA 10:15 AM Break 10:35 AM– Session 4: Human Papillomavirus (HPV): Diverse Sites of Infection with 12:00 PM Implications to Treatment and Prevention Moderators: T-C Wu, MD, PhD, and Elizabeth Read-Connole, PhD 10:35 Human Papillomavirus (HPV) Infection of the Anus Is More Prevalent and Diverse than Cervical HPV Infection Among HIV-Infected Women in the Study to Understand the Natural History of HIV/AIDS in the Era of Effective Therapy (SUN Study) Erna Kojic, MD, The Miriam Hospital, Providence, RI, USA 10:50 Six-Month History of Oral Versus Cervical Human Papillomavirus Infection Gypsyamber D’Souza, PhD, Johns Hopkins University, Baltimore, MD, USA 11:05 Clinical Profile of HIV-Positive Women with Cervical Cancer in India Aruna Alahari, MD, Tata Memorial Hospital, Mumbai, India 11:20 A High Prevalence of High Risk Human Papillomavirus and Cervical Dysplasia in HIV Seropositive Women in a Urban South African Cancer Cohort (SACCC) Cynthia Firnhaber, MD, University of Witwatersrand, Johannesburg, South Africa 11:35 Prevalence of Cervical Dysplasia in HIV-Positive Women in Jos, Nigeria Patricia Agaba, MD, AIDS Prevention Initiative in Nigeria, Jos University Teaching Hospital 4 10th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies Marriott Bethesda North Hotel & Conference Center, North Bethesda, Maryland October 16–17, 2006 Session 4, continued 11:50 Infrared Coagulator (IRC) for Treatment of High Grade Squamous Intraepithelial Neoplasia (HSIL) of the Anal Canal in HIV Infected Individuals: A Pilot Study (AMC 032) Elizabeth Stier, MD, Boston Medical Center, MA, USA 12:05 Interaction of HPV Pseudovirus with the Murine Female
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