The World's Most Influential Scientific Minds 2015
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NSABB June-July 2005 Meeting Agenda
First Meeting of the National Science Advisory Board for Biosecurity June 30 – July 1, 2005 Hyatt Regency Bethesda 7400 Wisconsin Ave. Bethesda, Maryland, 20814 USA Hotel Phone: 301-657-1234 Agenda Webcast: To watch the live webcast of the meeting, click here. The webcast can only be viewed when the meeting is in session at 8:00am-6:00pm on June 30 and at 8:00am-1:30pm on July 1 Eastern Time. You will need RealOne Player to view the webcast. If you do not already have RealOne Player on your computer, download here. Presentation slides: To access the following PowerPoint presentations, click on the presentation titles below. June 30, 2005 Opening Remarks and Swearing in Ceremony Elias Zerhouni, M.D. Director of the National Institutes of Health (NIH) Chair's Remarks and Agenda Overview Dennis L. Kasper, M.D. NSABB Chair Harvard Medical School Introduction of NSABB Members NSABB Structure and Operations Thomas Holohan, M.D. NSABB Executive Director, NIH Office of Biotechnology Activities Break Perspectives on Biosecurity in the Life Sciences NSABB Voting Members Impetus for NSABB: Enhancing Biosecurity on the Life Sciences Rajeev Venkayya, M.D. Special Assistant to the President, Senior Director for Biological and Chemical Defense White House Homeland Security Council Perspectives on Biosecurity in the Life Sciences NSABB Ex Officio Members Lunch Session I- The Development of Criteria for Identifying Dual Use Research and Research Results Introduction: Issues of Relevance to Criteria Development Arturo Casadevall, M.D., Ph.D. Professor of Medicine and of Microbiology & Immunology and Chief of Infectious Diseases Albert Einstein College of Medicine National Research Council Perspective: Experiments of Concern Ron Atlas, Ph.D. -
Chairman of the Opening Session
The Universe had (probably) an origin: on singularity theorems & quantum fluctuations Emilio Elizalde ICE/CSIC & IEEC Campus UAB, Barcelona Cosmology and the Quantum Vacuum III, Benasque, Sep 4-10, 2016 Some facts (a few rather surprising...) • Adam Riess, NP 2011, at Starmus (Tenerife), about Hubble: • “Hubble obtained the distances and redshifts of distant nebulae…” • “Hubble discovered that the Universe was expanding…” • No mention to Vesto Slipher, an extraordinary astronomer • Brian Schmidt, NP 2011, at Starmus (Tenerife) & Lisa Randall, Harvard U, in Barcelona, about Einstein: SHOES- • “Einstein was the first to think about the possibility of a ‘dark energy’…” Supernovae • No mention to Fritz Zwicky, another extraordinary astronomer • Fritz Zwicky discovered dark matter in the early 1930s while studying how galaxies move within the Coma Cluster • He was also the first to postulate and use nebulae as gravitational lenses (1937) • How easily* brilliant astronomers get dismissed • How easily* scientific myths arise *in few decades How did the “Big Bang” get its name ? http://www.bbc.co.uk/science/space/universe/scientists/fred_hoyle • Sir Fred Hoyle (1915–2001) English astronomer noted primarily for the theory of stellar nucleosynthesis (1946,54 groundbreaking papers) • Work on Britain's radar project with Hermann Bondi and Thomas Gold • William Fowler NP’83: “The concept of nucleosynthesis in stars was first established by Hoyle in 1946” • He found the idea universe had a beginning to be pseudoscience, also arguments for a creator, “…for it's an irrational process, and can't be described in scientific terms”; “…belief in the first page of Genesis” • Hoyle-Gold-Bondi 1948 steady state theory, “creation or C-field” • BBC radio's Third Programme broadcast on 28 Mar 1949: “… for this to happen you would need such a Big Bang!” Thus: Big Bang = Impossible blow!! But now: Big Bang ≈ Inflation ! • Same underlying physics as in steady state theory, “creation or C-field” • Richard C. -
What Is the Universe Made Of? How Old Is the Universe?
What is the Universe made of? How old is it? Charles H. Lineweaver University of New South Wales ABSTRACT For the past 15 years most astronomers have assumed that 95% of the Universe was in some mysterious form of cold dark matter. They also assumed that the cosmo- logical constant, ΩΛ, was Einstein’s biggest blunder and could be ignored. However, recent measurements of the cosmic microwave background combined with other cos- mological observations strongly suggest that 75% of the Universe is made of cosmo- logical constant (vacuum energy), while only 20% is made of non-baryonic cold dark matter. Normal baryonic matter, the stuff most physicists study, makes up about 5% of the Universe. If these results are correct, an unknown 75% of the Universe has been identified. Estimates of the age of the Universe depend upon what it is made of. Thus, our new inventory gives us a new age for the Universe: 13.4 ± 1.6 Gyr. “The history of cosmology shows us that in every age devout people believe that they have at last discovered the true nature of the Universe.” (E. Harrison in Cosmology: The Science of the Universe 1981) 1 Progress A few decades ago cosmology was laughed at for being the only science with no data. Cosmology was theory-rich but data-poor. It attracted armchair enthusiasts spouting speculations without data to test them. It was the only science where the errors could be kept in the exponents – where you could set the speed of light c =1, not for dimensionless convenience, but because the observations were so poor that it didn’t matter. -
Michael S. Brown, MD
DISTINGUISHED PHYSICIANS AND Michael S. Brown, M.D. Sir Richard Roberts, Ph.D. Winner, 1985 Nobel Prize in Physiology or Medicine Winner, 1993 Nobel Prize in Physiology or Medicine MEDICAL SCIENTISTS MENTORING Winner, 1988 Presidential National Medal of Science A globally prominent biochemist and molecular biologist, DELEGATES HAVE INCLUDED... Dr. Brown received the world’s most prestigious medical Dr. Roberts was awarded the Nobel Prize for his prize for his work describing the regulation of the groundbreaking contribution to discovering RNA splicing. cholesterol metabolism. His work laid the foundation for Dr. Roberts is dedicating his future research to GMO crops the class of drugs now called statins taken daily by more than 20 million and food sources, and demonstrating the effect they have on humanity. — GRANDg MASTERS — people worldwide. Ferid Murad, M.D., Ph.D. Mario Capecchi, Ph.D. Boris D. Lushniak, M.D., M.P.H Winner, 1998 Nobel Prize in Physiology or Medicine Academy Science Director The Surgeon General of the United States (acting, 2013-2014) Winner, 2007 Nobel Prize in Physiology or Medicine A world-renowned pioneer in biochemistry, Dr. Murad’s Winner, 2001 National Medal of Science Rear Admiral Lushniak, M.D., M.P.H., was the United award-winning research demonstrated that nitroglycerin Winner, 2001 Lasker Award States’ leading spokesperson on matters of public health, and related drugs help patients with heart conditions by Winner, 2003 Wolf Prize in Medicine overseeing the operations of the U.S. Public Health Service releasing nitric oxide into the body, thus relaxing smooth Mario Capecchi, Ph.D., a biophysicist, is a Distinguished Commissioned Corps, which consists of approximately muscles by elevating intracellular cyclic GMP, leading to vasodilation and Professor of Human Genetics at the University of Utah School of Medicine. -
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..f.,5$1______ -~ survey -------) WHO WAS WHO IN KINETICS, REACTION ENGINEERING, AND CATALYSIS CAMI L. JACKSON AND JOSEPH H . HOLLES University of liyoming • Laramie, WY 82071 n the tradition of "Who was Who in Transport Phenom We have tried to include the names that are encountered ena" by Byron Bird in Chemical Engineering Education,CI J frequently in textbooks for both undergraduates and gradu Iwe have developed a similar set of microbiographies for ates (by noted authors such as Levenspiel, Hill, Fogler, and persons in the fields of kinetics, reaction engineering, and Froment and Bischoff). Again, we follow Bird's lead and do catalysis. As noted by Bird, an otherwise typical lecture not include these people simply for authoring books in these can be enlivened by presenting biographical information fields . We do, however, include-where appropriate- famous about the people whose names appear in famous equations, texts written by those scientists and engineers included for dimensionless groups, plots, approximations, and theories . other reasons. We have tried to focus on those persons who The wide variety of applications for this type of information contributed to the science of a field and not just contributed to has been demonstrated by using activity breaks to teach the a specific reaction or system (e.g., Haber and Bosch). While history of our professionl21 and as trading card rewards for contributions to specific reactions or systems are important, academic performance _l31 we elected not to include them in order to limit the scope of With the introduction and widespread acceptance ofWiki the project. Finally, we have tried to include interesting non pedia, basic biographical information on many of the early technical or non-professional information where possible to contributors to the profession of chemical engineering can be show the breadth of these individuals. -
A Review of J. Craig Venter's a Life Decoded
A peer-reviewed electronic journal published by the Institute for Ethics and Emerging Technologies ISSN 1541-0099 17(1) – March 2008 A review of J. Craig Venter’s A Life Decoded Randy Mayes, Duke University Journal of Evolution and Technology - Vol. 17 Issue 1 – March 2008 - pgs 71-72 http://jetpress.org/v17/mayes.htm In the early 1980s, a number of researchers suggested sequencing and mapping the human genome to help the science community better understand diseases and evolution. Following the announcement that the human genome had been sequenced, scientists wrote in peer-reviewed journals that we are not as hardwired as was once believed, and that the sequencing of the genome was just the beginning. Today, researchers have a new set of goals. In popular journalism, however, the science was lost in the shuffle. The media focused more on the dynamics of the conflicting philosophies of the private and public projects. This emphasis is also clear in the titles of several books chronicling the Human Genome Project, all appearing prior to the recent release of Craig Venter’s autobiography, A Life Decoded: My Genome: My Life (2007). Readers will find that Robert Cook-Deegan’s The Gene Wars (1995) and The Common Thread by Sir John Sulston and Georgina Ferry (2002), both written by insiders, are biased towards the philosophy of the public project, a commons approach. Sulston is a socialist who grows runner beans and drives a second hand car. By contrast, Venter travels in Lear jets and conducts business from his yacht. Three other books are more objective. -
Tinkering with Time the NEW TIME TRAVELERS: a JOURNEY to the on Our FRONTIERS of PHYSICS by DAVID TOOMEY Bookshelf W
BOOKS & ARTS Tinkering with time THE NEW TIME TRAVELERS: A JOURNEY TO THE On our FRONTIERS OF PHYSICS BY DAVID TOOMEY bookshelf W. W. Norton & Co.: 2007. 320 pp. $25.95 Years ago, David Toomey picked up H. G. Wells’ moving clocks tick slowly, making time travel The Time Machine and couldn’t put it down. to the future possible. We now know a number The Mathematics of He was most interested in the drawing-room of solutions to Einstein’s equations of general Egypt, Mesopotamia, discussion between the time traveller and his relativity (1915) that are sufficiently twisted to China, India, and Islam: friends in which time as a fourth dimension was allow time travel to the past: Kurt Gödel’s 1949 A Sourcebook discussed, but wanted to know more about just rotating universe; the Morris–Thorne–Yurtsever edited by Victor J. Katz how that time machine might work. Toomey was wormhole (1988); the Tipler–van Stockum infinite therefore delighted to learn that that drawing- rotating cylinder, moving cosmic strings (myself), Princeton Univ. Press: room conversation continues today — this time the rotating black-hole interior (Brandon Carter), 2007. 685 pp. $75 among physicists. a Roman ring of wormholes (Matt Visser), the We’re aware that Toomey captures well the personalities Everett–Alcubierre warp drive, my and Li–Xin Li’s the ancient cultures of the ‘new time travelers’ — those physicists self-creating universe; Amos Ori’s torus; and were mathematically interested in whether time travel to the past is others. The book discusses all of these. advanced. Now possible — from Stephen Hawking’s sense of But can a time machine really be constructed? translations of early texts humour to Kip Thorne’s penchant for placing Hawking, like one of the time traveller’s sceptical from five key regions are scientific bets. -
ACCRETION INTO and EMISSION from BLACK HOLES Thesis By
ACCRETION INTO AND EMISSION FROM BLACK HOLES Thesis by Don Nelson Page In Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy California Institute of Technology Pasadena, California 1976 (Submitted May 20, 1976) -ii- ACKNOHLEDG:-IENTS For everything involved during my pursuit of a Ph. D. , I praise and thank my Lord Jesus Christ, in whom "all things were created, both in the heavens and on earth, visible and invisible, whether thrones or dominions or rulers or authorities--all things have been created through Him and for Him. And He is before all things, and in Him all things hold together" (Colossians 1: 16-17) . But He is not only the Creator and Sustainer of the universe, including the physi cal laws which rule and their dominion the spacetime manifold and its matter fields ; He is also my personal Savior, who was "wounded for our transgressions , ... bruised for our iniquities, .. and the Lord has lald on Him the iniquity of us all" (Isaiah 53:5-6). As the Apostle Paul expressed it shortly after Isaiah ' s prophecy had come true at least five hundred years after being written, "God demonstrates His own love tmvard us , in that while we were yet sinners, Christ died for us" (Romans 5 : 8) . Christ Himself said, " I have come that they may have life, and have it to the full" (John 10:10) . Indeed Christ has given me life to the full while I have been at Caltech, and I wish to acknowledge some of the main blessings He has granted: First I thank my advisors , KipS. -
Humankind 2.0: the Technologies of the Future 6. Biotech
Humankind 2.0: The Technologies of the Future 6. Biotech Piero Scaruffi, 2017 See http://www.scaruffi.com/singular/human20.html for the full text of this discussion A brief History of Biotech 1953: Discovery of the structure of the DNA 2 A brief History of Biotech 1969: Jon Beckwith isolates a gene 1973: Stanley Cohen and Herbert Boyer create the first recombinant DNA organism 1974: Waclaw Szybalski coins the term "synthetic biology” 1975: Paul Berg organizes the Asilomar conference on recombinant DNA 3 A brief History of Biotech 1976: Genentech is founded 1977: Fred Sanger invents a method for rapid DNA sequencing and publishes the first full DNA genome of a living being Janet Rossant creates a chimera combining two mice species 1980: Genentech’s IPO, first biotech IPO 4 A brief History of Biotech 1982: The first biotech drug, Humulin, is approved for sale (Eli Lilly + Genentech) 1983: Kary Mullis invents the polymerase chain reaction (PCR) for copying genes 1986: Leroy Hood invents a way to automate gene sequencing 1986: Mario Capecchi performs gene editing on a mouse 1990: William French Anderson’s gene therapy 1990: First baby born via PGD (Alan Handyside’s lab) 5 A brief History of Biotech 1994: FlavrSavr Tomato 1994: Maria Jasin’s homing endonucleases for genome editing 1996: Srinivasan Chandrasegaran’s ZFN method for genome editing 1996: Ian Wilmut clones the first mammal, the sheep Dolly 1997: Dennis Lo detects fetal DNA in the mother’s blood 2000: George Davey Smith introduces Mendelian randomization 6 A brief History of Biotech -
On Jim Watson's APOE Status: Genetic Information Is Hard to Hide
European Journal of Human Genetics (2009) 17, 147–150 & 2009 Macmillan Publishers Limited All rights reserved 1018-4813/09 $32.00 www.nature.com/ejhg LETTERS 15.6 (95% CI, 10.9–22.5) and 4.3 (95% CI, 3.3–5.5) for APOE e4 homozygotes and e4/e3 heterozygotes respectively, 6 On Jim Watson’s APOE compared to e3 homozygotes. The meta-analytic odds ratios in population-based Caucasian samples were 11.8 status: genetic (95% CI, 7.0–19.8) and 2.8 (95% CI, 2.3–3.5), respec- tively.6 In a large Rotterdam (Netherlands), population- information is hard to based prospective study of people aged 55 years or above, it hide was estimated that 17% of the overall risk of AD could be attributed to the e4 allele, with 3% (95% CI, 0–6%) of cases attributed to the e4/e4 genotype, and 14% (95% CI, 7–21%) European Journal of Human Genetics (2009) 17, 147–149; 7 to the e4/e3 genotype. doi:10.1038/ejhg.2008.198; published online 22 October 2008 A recent investigation of LD for 50 SNPs in and surrounding APOE in 550 Caucasians identified multiple SNPs in the TOMM40 gene B15 kb upstream of APOE, and The recent publication and release to public databases of at least one SNP in the other surrounding genes LU, PVRL2, Dr James Watson’s sequenced genome,1 with the exception APOC1, APOC4 and CLPTM1 were associated with LOAD of all gene information about apolipoprotein E (ApoE), risk.8 In particular, the C allele of SNP rs157581 in provides a pertinent example of the challenges concerning TOMM40 is in strong LD (r240.6) with the C allele of privacy and the complexities of informed consent in the rs429358 in APOE, which defines the e4 allele. -
Synthetic Biology - Mapping the Patent Landscape Paul Oldham 1,2 Stephen Hall 3 1
bioRxiv preprint doi: https://doi.org/10.1101/483826; this version posted November 30, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Synthetic Biology - Mapping the Patent Landscape Paul Oldham 1,2 Stephen Hall 3 1. Industrial Fellow, Manchester Institute of Innovation Research, Alliance Manchester Business School, Manchester University. 2 Senior Visiting Fellow, Institute for the Advanced Study of Sustainability, United Nations University 3. Information System Services, Lancaster University Abstract This article presents the global patent landscape for synthetic biology as a new and emerging area of science and technology. The aim of the article is to provide an overview of the emergence of synthetic biology in the patent system and to contribute to future research by providing a high quality tagged core dataset with 7,424 first filings and 71,887 family members. This dataset is intended to assist with evidence based exploration of synthetic biology in the patent system and with advancing methods for the analysis of new and emerging areas of science and technology. The starting point for the research is recognition that traditional methods of patent landscape analysis based on key word searches face limitations when addressing new and emerging areas of science and technology. Synthetic biology can be broadly described as involving the design, synthesis and assembly of biological parts, circuits, pathways, cells and genomes. As such synthetic biology can be understood as emerging from a combination of overlaps and convergences between existing fields and disciplines, such as biotechnology, genetic engineering, protein engineering and systems biology. -
What's Inside
Newsletter A publication of the Controlled Release Society Volume 33 • Number 1 • 2016 What’s Inside Modern Drug–Medical Device Combination Products Controlled Release of Levofloxacin from Vitamin E Loaded Silicone- Hydrogel Contact Lenses Encapsulation of Gold Nanoparticles to Visualize Intracellular Localization of Lipid and Polymer-Based Nanocarriers The One Health Initiative and Its Impact on Drug Development DDTR Update Chapter News Controlled Release Society Annual Meeting & Exposition July 17–20, 2016 Seattle, Washington, U.S.A. COLLABORATE CONNECT INNOVATE Registration Opens in March! Visit controlledreleasesociety.org for the latest details. Don’t miss out on the must-attend event in delivery science and technology! This is your opportunity to: • Learn about cutting-edge research and innovation • Meet esteemed industry experts, researchers, and young scientists • Build your network and collaborate controlledreleasesociety.org Newsletter Charles Frey Vol. 33 • No. 1 • 2016 Editor > TABLE OF CONTENTS 4 From the Editor 5 Preclinical Sciences & Animal Health The One Health Initiative and Its Impact on Drug Development Steven Giannos Editor 8 Special Feature Modern Drug-Medical Device Combination Products 10 Scientifically Speaking Controlled Release of Levofloxacin from Vitamin E Loaded Silicone-Hydrogel Contact Lenses 12 Scientifically Speaking Encapsulation of Gold Nanoparticles to Visualize Intracellular Arlene McDowell Localization of Lipid and Polymer-Based Nanocarriers Editor 15 CRS Foundation 2016 Allan Hoffman Student Travel Grant Program 16 Chapter News Drug Delivery Australia 18 Chapter News Rheology: How to Get into the Flow Bozena Michniak-Kohn 20 Chapter News Editor Micro- and Nanotechnologies to Overcome Biological Barriers: Eighth Annual CRS Italy Local Chapter Workshop 22 DDTR Update Drug Delivery and Translational Research Update 24 People in the News 25 Companies in the News Yvonne Perrie Editor Cover image: ©krugloff / Shutterstock.com Rod Walker Editor 3 > FROM THE EDITOR Editors Charles Frey Steven Giannos Roderick B.