Journal of Stroke 2016;18(2):195-202 http://dx.doi.org/10.5853/jos.2015.01669 Original Article Left Ventricular Diastolic Dysfunction in Ischemic Stroke: Functional and Vascular Outcomes Hong-Kyun Park,a* Beom Joon Kim,a* Chang-Hwan Yoon,b Mi Hwa Yang,a Moon-Ku Han,a Hee-Joon Baea aDepartment of Neurology and Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Korea bDivision of Cardiology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea Background and Purpose Left ventricular (LV) diastolic dysfunction, developed in relation to myo- Correspondence: Moon-Ku Han cardial dysfunction and remodeling, is documented in 15%-25% of the population. However, its role Department of Neurology and Cerebrovascular Center, Seoul National in functional recovery and recurrent vascular events after acute ischemic stroke has not been thor- University Bundang Hospital, oughly investigated. 82 Gumi-ro 173beon-gil, Bundang-gu, Seongnam 13620, Korea Methods In this retrospective observational study, we identified 2,827 ischemic stroke cases with Tel: +82-31-787-7464 adequate echocardiographic evaluations to assess LV diastolic dysfunction within 1 month after the Fax: +82-31-787-4059 index stroke. The peak transmitral filling velocity/mean mitral annular velocity during early diastole (E/ E-mail:
[email protected] e’) was used to estimate LV diastolic dysfunction. We divided patients into 3 groups according to E/e’ Received: December 1, 2015 as follows: <8, 8-15, and ≥15. Recurrent vascular events and functional recovery were prospectively Revised: March 14, 2016 collected at 3 months and 1 year. Accepted: March 21, 2016 Results Among included patients, E/e’ was 10.6±6.4: E/e’ <8 in 993 (35%), 8-15 in 1,444 (51%), and *These authors contributed equally to this ≥15 in 378 (13%) cases.