Challenges to American Institutions Academy Inducts 232Nd Class of Members
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Applied Category Theory for Genomics – an Initiative
Applied Category Theory for Genomics { An Initiative Yanying Wu1,2 1Centre for Neural Circuits and Behaviour, University of Oxford, UK 2Department of Physiology, Anatomy and Genetics, University of Oxford, UK 06 Sept, 2020 Abstract The ultimate secret of all lives on earth is hidden in their genomes { a totality of DNA sequences. We currently know the whole genome sequence of many organisms, while our understanding of the genome architecture on a systematic level remains rudimentary. Applied category theory opens a promising way to integrate the humongous amount of heterogeneous informations in genomics, to advance our knowledge regarding genome organization, and to provide us with a deep and holistic view of our own genomes. In this work we explain why applied category theory carries such a hope, and we move on to show how it could actually do so, albeit in baby steps. The manuscript intends to be readable to both mathematicians and biologists, therefore no prior knowledge is required from either side. arXiv:2009.02822v1 [q-bio.GN] 6 Sep 2020 1 Introduction DNA, the genetic material of all living beings on this planet, holds the secret of life. The complete set of DNA sequences in an organism constitutes its genome { the blueprint and instruction manual of that organism, be it a human or fly [1]. Therefore, genomics, which studies the contents and meaning of genomes, has been standing in the central stage of scientific research since its birth. The twentieth century witnessed three milestones of genomics research [1]. It began with the discovery of Mendel's laws of inheritance [2], sparked a climax in the middle with the reveal of DNA double helix structure [3], and ended with the accomplishment of a first draft of complete human genome sequences [4]. -
Arxiv:1006.1489V2 [Math.GT] 8 Aug 2010 Ril.Ias Rfie Rmraigtesre Rils[14 Articles Survey the Reading from Profited Also I Article
Pure and Applied Mathematics Quarterly Volume 8, Number 1 (Special Issue: In honor of F. Thomas Farrell and Lowell E. Jones, Part 1 of 2 ) 1—14, 2012 The Work of Tom Farrell and Lowell Jones in Topology and Geometry James F. Davis∗ Tom Farrell and Lowell Jones caused a paradigm shift in high-dimensional topology, away from the view that high-dimensional topology was, at its core, an algebraic subject, to the current view that geometry, dynamics, and analysis, as well as algebra, are key for classifying manifolds whose fundamental group is infinite. Their collaboration produced about fifty papers over a twenty-five year period. In this tribute for the special issue of Pure and Applied Mathematics Quarterly in their honor, I will survey some of the impact of their joint work and mention briefly their individual contributions – they have written about one hundred non-joint papers. 1 Setting the stage arXiv:1006.1489v2 [math.GT] 8 Aug 2010 In order to indicate the Farrell–Jones shift, it is necessary to describe the situation before the onset of their collaboration. This is intimidating – during the period of twenty-five years starting in the early fifties, manifold theory was perhaps the most active and dynamic area of mathematics. Any narrative will have omissions and be non-linear. Manifold theory deals with the classification of ∗I thank Shmuel Weinberger and Tom Farrell for their helpful comments on a draft of this article. I also profited from reading the survey articles [14] and [4]. 2 James F. Davis manifolds. There is an existence question – when is there a closed manifold within a particular homotopy type, and a uniqueness question, what is the classification of manifolds within a homotopy type? The fifties were the foundational decade of manifold theory. -
A HISTORY of the HEBREW TABERNACLE CONGREGATION of WASHINGTON HEIGHTS a German-Jewish Community in New York City
A HISTORY OF HEBREW TABERNACLE A HISTORY OF THE HEBREW TABERNACLE CONGREGATION OF WASHINGTON HEIGHTS A German-Jewish Community in New York City With An Introduction by Rabbi Robert L. Lehman, D. Min., D.D. December 8, 1985 Chanukah, 5746 by Evelyn Ehrlich — 1 — A HISTORY OF HEBREW TABERNACLE THANK YOU Many individuals have contributed toward making this project possible, not the least of which were those who helped with their financial contributions. They gave “in honor” as well as “in memory” of individuals and causes they held dear. We appreciate their gifts and thank them in the name of the congregation. R.L.L. IN MEMORY OF MY DEAR ONES by Mrs. Anna Bondy TESSY & MAX BUCHDAHL by their loved ones, Mr. and Mrs. Ernst Grumbacher HERBERT KANN by his wife, Mrs. Lore Kann FRED MEYERHOFF by his wife, Mrs. Rose Meyerhoff ILSE SCHLOSS by her husband, Mr. Kurt J. Schloss JULIUS STERN by his wife, Mrs. Bella Stern ROBERT WOLEMERINGER by his wife, Mrs. Friedel Wollmeringer IN HONOR OF AMY, DEBORAH & JOSHUA BAUML by their grandmother, Mrs. Elsa Bauml the CONGREGATION by Mrs. Gerda Dittman, Mr. & Mrs. Paul Ganzman, Ms. Bertha Kuba, Mr. & Mrs. Nathan Maier, Mrs. Emma Michel, Mrs. Ada Speyer (deceased 1984), Mrs. Joan Wickert MICHELLE GLASER and STEVEN GLASER by their grandmother, Mrs. Anna Bondy RAQUEL and RUSSELL PFEFFER by their grandparents, Mr. and Mrs. Rudolph Oppenheimer HANNA ROTHSTEIN by her friend, Mrs. Stephanie Goldmann and by two donors who wish to remain anonymous — 2 — A HISTORY OF HEBREW TABERNACLE INTRODUCTION Several factors were instrumental in the writing of this history of our congregation. -
Masthead (PDF)
Proceedings of the National Academy ofPNAS Sciences of the United States of America www.pnas.org PRESIDENT OF Robert G. Roeder Geophysics John J. Mekalanos THE ACADEMY Michael Rosbash Michael L. Bender Peter Palese Ralph J. Cicerone David D. Sabatini Thomas E. Shenk Gertrud M. Schupbach Human Environmental Thomas J. Silhavy SENIOR EDITOR Robert Tjian Sciences Peter K. Vogt Solomon H. Snyder Susan Hanson Cellular and Molecular Physics ASSOCIATE EDITORS Neuroscience Immunology Anthony Leggett William C. Clark Pietro V. De Camilli Peter Cresswell Paul C. Martin Alan Fersht Richard L. Huganir Douglas T. Fearon Jack Halpern L. L. Iversen Richard A. Flavell Physiology and Jeremy Nathans Charles F. Stevens Dan R. Littman Pharmacology Thomas C. Su¨dhof Tak Wah Mak Susan G. Amara Joseph S. Takahashi William E. Paul David Julius EDITORIAL BOARD Hans Thoenen Michael Sela Ramon Latorre Ralph M. Steinman Masashi Yanagisawa Animal, Nutritional, and Chemistry Applied Microbial Sciences Stephen J. Benkovic Mathematics Plant Biology David L. Denlinger Bruce J. Berne Richard V. Kadison Maarten J. Chrispeels R. Michael Roberts Harry B. Gray Robion C. Kirby Enrico Coen Robert Haselkorn Linda J. Saif Mark A. Ratner George H. Lorimer Ryuzo Yanagimachi Barry M. Trost Medical Genetics, Hematology, and Nicholas J. Turro Anthropology Oncology Plant, Soil, and Charles T. Esmon Microbial Sciences Jeremy A. Sabloff Computer and Joseph L. Goldstein Roger N. Beachy Information Sciences Mark T. Groudine Steven E. Lindow Applied Mathematical Sciences Shafrira Goldwasser David O. Siegmund Tony Hunter M. S. Swaminathan Philip W. Majerus Susan R. Wessler Economic Sciences Newton E. Morton Applied Physical Sciences Ronald W. -
Looking at Earth: an Astronaut's Journey Induction Ceremony 2017
american academy of arts & sciences winter 2018 www.amacad.org Bulletin vol. lxxi, no. 2 Induction Ceremony 2017 Class Speakers: Jane Mayer, Ursula Burns, James P. Allison, Heather K. Gerken, and Gerald Chan Annual David M. Rubenstein Lecture Looking at Earth: An Astronaut’s Journey David M. Rubenstein and Kathryn D. Sullivan ALSO: How Are Humans Different from Other Great Apes?–Ajit Varki, Pascal Gagneux, and Fred H. Gage Advancing Higher Education in America–Monica Lozano, Robert J. Birgeneau, Bob Jacobsen, and Michael S. McPherson Redistricting and Representation–Patti B. Saris, Gary King, Jamal Greene, and Moon Duchin noteworthy Select Prizes and Andrea Bertozzi (University of James R. Downing (St. Jude Chil- Barbara Grosz (Harvard Univer- California, Los Angeles) was se- dren’s Research Hospital) was sity) is the recipient of the Life- Awards to Members lected as a 2017 Simons Investi- awarded the 2017 E. Donnall time Achievement Award of the gator by the Simons Foundation. Thomas Lecture and Prize by the Association for Computational American Society of Hematology. Linguistics. Nobel Prize in Chemistry, Clara D. Bloomfield (Ohio State 2017 University) is the recipient of the Carol Dweck (Stanford Univer- Christopher Hacon (University 2017 Robert A. Kyle Award for sity) was awarded the inaugural of Utah) was awarded the Break- Joachim Frank (Columbia Univer- Outstanding Clinician-Scientist, Yidan Prize. through Prize in Mathematics. sity) presented by the Mayo Clinic Di- vision of Hematology. Felton Earls (Harvard Univer- Naomi Halas (Rice University) sity) is the recipient of the 2018 was awarded the 2018 Julius Ed- Nobel Prize in Economic Emmanuel J. -
Medical Advisory Board September 1, 2006–August 31, 2007
hoWard hughes medical iNstitute 2007 annual report What’s Next h o W ard hughes medical i 4000 oNes Bridge road chevy chase, marylaNd 20815-6789 www.hhmi.org N stitute 2007 a nn ual report What’s Next Letter from the president 2 The primary purpose and objective of the conversation: wiLLiam r. Lummis 6 Howard Hughes Medical Institute shall be the promotion of human knowledge within the CREDITS thiNkiNg field of the basic sciences (principally the field of like medical research and education) and the a scieNtist 8 effective application thereof for the benefit of mankind. Page 1 Page 25 Page 43 Page 50 seeiNg Illustration by Riccardo Vecchio Südhof: Paul Fetters; Fuchs: Janelia Farm lab: © Photography Neurotoxin (Brunger & Chapman): Page 3 Matthew Septimus; SCNT images: by Brad Feinknopf; First level of Rongsheng Jin and Axel Brunger; iN Bruce Weller Blake Porch and Chris Vargas/HHMI lab building: © Photography by Shadlen: Paul Fetters; Mouse Page 6 Page 26 Brad Feinknopf (Tsai): Li-Huei Tsai; Zoghbi: Agapito NeW Illustration by Riccardo Vecchio Arabidopsis: Laboratory of Joanne Page 44 Sanchez/Baylor College 14 Page 8 Chory; Chory: Courtesy of Salk Janelia Farm guest housing: © Jeff Page 51 Ways Illustration by Riccardo Vecchio Institute Goldberg/Esto; Dudman: Matthew Szostak: Mark Wilson; Evans: Fred Page 10 Page 27 Septimus; Lee: Oliver Wien; Greaves/PR Newswire, © HHMI; Mello: Erika Larsen; Hannon: Zack Rosenthal: Paul Fetters; Students: Leonardo: Paul Fetters; Riddiford: Steitz: Harold Shapiro; Lefkowitz: capacity Seckler/AP, © HHMI; Lowe: Zack Paul Fetters; Map: Reprinted by Paul Fetters; Truman: Paul Fetters Stewart Waller/PR Newswire, Seckler/AP, © HHMI permission from Macmillan Page 46 © HHMI for Page 12 Publishers, Ltd.: Nature vol. -
CURRICULUM VITAE George M. Weinstock, Ph.D
CURRICULUM VITAE George M. Weinstock, Ph.D. DATE September 26, 2014 BIRTHDATE February 6, 1949 CITIZENSHIP USA ADDRESS The Jackson Laboratory for Genomic Medicine 10 Discovery Drive Farmington, CT 06032 [email protected] phone: 860-837-2420 PRESENT POSITION Associate Director for Microbial Genomics Professor Jackson Laboratory for Genomic Medicine UNDERGRADUATE 1966-1967 Washington University EDUCATION 1967-1970 University of Michigan 1970 B.S. (with distinction) Biophysics, Univ. Mich. GRADUATE 1970-1977 PHS Predoctoral Trainee, Dept. Biology, EDUCATION Mass. Institute of Technology, Cambridge, MA 1977 Ph.D., Advisor: David Botstein Thesis title: Genetic and physical studies of bacteriophage P22 genomes containing translocatable drug resistance elements. POSTDOCTORAL 1977-1980 Postdoctoral Fellow, Department of Biochemistry TRAINING Stanford University Medical School, Stanford, CA. Advisor: Dr. I. Robert Lehman. ACADEMIC POSITIONS/EMPLOYMENT/EXPERIENCE 1980-1981 Staff Scientist, Molec. Gen. Section, NCI-Frederick Cancer Research Facility, Frederick, MD 1981-1983 Staff Scientist, Laboratory of Genetics and Recombinant DNA, NCI-Frederick Cancer Research Facility, Frederick, MD 1981-1984 Adjunct Associate Professor, Department of Biological Sciences, University of Maryland, Baltimore County, Catonsville, MD 1983-1984 Senior Scientist and Head, DNA Metabolism Section, Lab. Genetics and Recombinant DNA, NCI-Frederick Cancer Research Facility, Frederick, MD 1984-1990 Associate Professor with tenure (1985) Department of Biochemistry -
RMM00006 B.Pdf
This document is from the Cornell University Library's Division of Rare and Manuscript Collections located in the Carl A. Kroch Library. If you have questions regarding this document or the information it contains, contact us at the phone number or e-mail listed below. Our website also contains research information and answers to frequently asked questions. http://rmc.library.cornell.edu Division of Rare and Manuscript Collections 2B Carl A. Kroch Library Cornell University, Ithaca, NY 14853 Phone: (607) 255-3530 Fax: (607) 255-9524 E-mail: [email protected] PREFACE TO THE LETTERBOOK INDEX The letterbooks of Jacob Gould Schurman were maintained in his office by several persons over his twenty eight year incumbency, resulting in significant variations in control, style, and judgment. Moreover, indexes to each volume were kept by handwritten notation, in both pencil and ink, seldom in alphabetical order, and with numerous addenda and instances of inserted or corrected text. Researchers should exercise special and unusual latitude in an attempt to gather all the citations for a specific name. There are a number of variant patterns, but the most consistent apply to abbreviated versions of the name of the same person. "Cunningham, ~riggs"may be the same as "Cunningham, B." I,Dann, H. E ." may be the same as "Dann, H. H." (due to blurred or illegible handwriting). "Campbell, E. P." may be the same as "Campbell, President" (or Senator, Governor, Secretary, etc.). In many cases the index has knowingly been recreated literally from the original volume indexes with the mistakes intact to avoid an even more confusing, erroneous and unconfirmable interpretation. -
Inauguration of John Grier Hibben
INAUGURATION O F J O H N G R I E R H I B B E N PRESIDENT OF PRINCETON UNIVERSITY AT RDAY MAY S U , THE ELEVENTH MCMXII INAUGURATION O F J O H N G R I E R H I B B E N PRESIDENT OF PRINCETON UNIVERSITY SATUR AY MAY THE ELE ENTH D , V MCMXII PROGRAMME AN D ORDER OF ACADEMI C PROCESSION INAUGURAL EXERCISES at eleven o ’ clock March from Athalia Mendelssohn Veni Creator Spiritus Palestrina SC RI PTUR E AN D P RAYE R HENRY. VAN DYKE Murray Professor of English Literature ADM I N I STRATI ON O F T H E OATH O F OFF I CE MAHLON PITNEY Associat e Justice of the Supreme Court of the United States D ELIVE RY O F T H E CHARTE R AN D KEYS JOHN AIKMAN STEWART e E " - n S nior Trustee, President pro tempore of Pri ceton University I NAUGURAL ADD RE SS JOHN GRIER HIBBEN President of Princeton University CONFE RR ING O F HONORARY D EGREES O Il EDWARD D OUGLASS W H I T E T h e Chief Justice of the United States WILLIAM HOWARD TAFT President of the United States T H E O N E HUND REDTH P SALM Sung in unison by choir and assembly standing Accompaniment of trumpets BENED I CT I ON EDWIN STEVENS LINES Bishop of Newark Postlude Svendsen (The audience ls re"uested to stand while the academic "rocession ls enterlng and "assing out) ALUMNI LUNCHEON T h e Gymnasium ’ at "uarter before one O clock ’ M . -
2011 Annual Report
Memorial Sloan-Kettering Cancer Center 2011 Annual Report 10 steps closer 10 steps closer Letter from the Chairman and the President 1 1 | First effective treatments for advanced melanoma 5 2 Genomic analysis offers clues to most common | type of ovarian cancer 7 3 Breast cancer surgery: practice-changing | findings for some patients 9 4 New drugs offer survival benefit for men | with metastatic prostate cancer 11 5 | Insights into DNA damage and repair 13 6 Novel stem cell technique shows promise | in treating disease 15 7 Combination therapy may prevent spread | of nasopharyngeal tumors 17 8 Algorithm can predict shape of proteins, | speeding basic cancer research 19 9 Two of 2011’s top five advances in cancer | research led by MSKCC physician-scientists 21 10 | The Josie Robertson Surgery Center 23 The Campaign for Memorial Sloan-Kettering 25 Statistical Profile 27 Financial Summary 29 Boards of Overseers and Managers 31 www.mskcc.org/annualreport Letter from the Chairman and the President The year 2011 was a strong one at Memorial Sloan-Kettering. We continued to lead across “Our success as an institution is due in the spectrum of patient care, research, and training, and laid the groundwork for important progress in the years ahead. great measure to our remarkable staff… We want to begin by saying that our success as an institution is due in great measure to our remarkable staff. On a daily basis, we are inspired by their dedication and compassion, and We are inspired by their dedication Douglas A. Warner III are grateful for the work they do in the service of our patients and our mission. -
GSA Welcomes 2012 Board Members
7INTERs3PRING 4HE'3!2EPORTER winter s spring 2012 New Executive GSA Welcomes 2012 Board Members Director Now on Board The Genetics Society of America New Members of the GSA Board of welcomes four new members elected Directors Adam P. Fagen, by the general membership to the Ph.D., stepped in as 2012 GSA Board of Directors. The VICE PRESIDENT: GSA’s new Executive new members are: Michael Lynch Michael Lynch, Director beginning (Indiana University), who serves as Distinguished December 1, 2011. vice president in 2012 and as GSA Professor of Dr. Fagen previously president in 2013 and Marnie E. Biology, Class of was at the American Halpern (Carnegie Institution for 1954 Professor, Society of Plant Science); Mohamed Noor (Duke Department of Biologists (ASPB), University); and John Schimenti Biology, Indiana where he was the director of public (Cornell University), who will serve as University, continued on page nineteen directors. Bloomington. Dr. Lynch is a population and evolutionary biologist and a In addition to these elected officers, long-time member of GSA. Dr. Lynch 2012 Brenda J. Andrews (University of sees GSA as the home for geneticists Toronto), Editor-in-Chief of GSA’s who study a broad base of topics GSA Award journal, G3: Genes|Genomes|Genetics, and organisms, and as a forum Recipients which was first published online in where general discussion occurs, June 2011, becomes a member of the whether based on the principles Announced Board of Directors. The bylaws have of genetics, the most pressing historically included the GENETICS GSA is pleased to announce the issues within the discipline itself, or editor-in-chief on the Board and as a responses to societal concerns and/ 2012 recipients of its five awards result of a 2011 bylaw revision, the G3 for distinguished service in the or conflicts within applied genetics. -
Resubmission JBC Frescas and De Lange
Cell Biology: Binding of TPP1 Protein to TIN2 Protein Is Required for POT1a,b Protein-mediated Telomere Protection David Frescas and Titia de Lange J. Biol. Chem. 2014, 289:24180-24187. doi: 10.1074/jbc.M114.592592 originally published online July 23, 2014 Downloaded from Access the most updated version of this article at doi: 10.1074/jbc.M114.592592 http://www.jbc.org/ Find articles, minireviews, Reflections and Classics on similar topics on the JBC Affinity Sites. Alerts: • When this article is cited • When a correction for this article is posted at Rockefeller University Library on August 31, 2014 Click here to choose from all of JBC's e-mail alerts This article cites 29 references, 13 of which can be accessed free at http://www.jbc.org/content/289/35/24180.full.html#ref-list-1 THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 289, NO. 35, pp. 24180–24187, August 29, 2014 © 2014 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A. Binding of TPP1 Protein to TIN2 Protein Is Required for POT1a,b Protein-mediated Telomere Protection* Received for publication, June 30, 2014, and in revised form, July 22, 2014 Published, JBC Papers in Press, July 23, 2014, DOI 10.1074/jbc.M114.592592 David Frescas and Titia de Lange1 From the Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York 10065 Background: Chromosome ends require the TPP1/POT1 heterodimers for protection. Results: A TIN2 mutant that fails to bind TPP1 resulted in phenotypes associated with TPP1/POT1 deletion.