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12-21-2016 Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I Jalal K. Siddiqui The Ohio State University
Svetlana B. Tikunova The Ohio State University
Shane D. Walton The Ohio State University
Bin Liu The Ohio State University
Meredith Meyer The Ohio State University
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Repository Citation Siddiqui, Jalal K.; Tikunova, Svetlana B.; Walton, Shane D.; Liu, Bin; Meyer, Meredith; de Tombe, Pieter P.; Neilson, Nathan; Kekenes- Huskey, Peter M.; Salhi, Hussam E.; Janssen, Paul M.L.; Biesiadecki, Brandon J.; and Davis, Jonathan P., "Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I" (2016). Chemistry Faculty Publications. 101. https://uknowledge.uky.edu/chemistry_facpub/101
This Article is brought to you for free and open access by the Chemistry at UKnowledge. It has been accepted for inclusion in Chemistry Faculty Publications by an authorized administrator of UKnowledge. For more information, please contact [email protected]. Authors Jalal K. Siddiqui, Svetlana B. Tikunova, Shane D. Walton, Bin Liu, Meredith Meyer, Pieter P. de Tombe, Nathan Neilson, Peter M. Kekenes-Huskey, Hussam E. Salhi, Paul M.L. Janssen, Brandon J. Biesiadecki, and Jonathan P. Davis
Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I
Notes/Citation Information Published in Frontiers in Physiology, v. 7, 632, p. 1-14.
© 2016 Siddiqui, Tikunova, Walton, Liu, Meyer, de Tombe, Neilson, Kekenes-Huskey, Salhi, Janssen, Biesiadecki and Davis.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Digital Object Identifier (DOI) http://doi.org/10.3389/fphys.2016.00632
This article is available at UKnowledge: https://uknowledge.uky.edu/chemistry_facpub/101 ORIGINAL RESEARCH published: 21 December 2016 doi: 10.3389/fphys.2016.00632
Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I
Jalal K. Siddiqui 1, Svetlana B. Tikunova 1, Shane D. Walton 1, Bin Liu 1, Meredith Meyer 1, Pieter P. de Tombe 2, Nathan Neilson 1, Peter M. Kekenes-Huskey 3, Hussam E. Salhi 1, Paul M. L. Janssen 1, Brandon J. Biesiadecki 1 and Jonathan P. Davis 1*
1 Department of Physiology and Cell Biology and the Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA, 2 Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL, USA, 3 Department of Chemistry, University of Kentucky, Lexington, KY, USA
Control of calcium binding to and dissociation from cardiac troponin C (TnC) is essential to healthy cardiac muscle contraction/relaxation. There are numerous aberrant post-translational modifications and mutations within a plethora of contractile, and even non-contractile, proteins that appear to imbalance this delicate relationship. The Edited by: P. Bryant Chase, direction and extent of