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12-21-2016 Myofilament Sensitivity: Consequences of the Effective Concentration of I Jalal K. Siddiqui The Ohio State University

Svetlana B. Tikunova The Ohio State University

Shane D. Walton The Ohio State University

Bin Liu The Ohio State University

Meredith Meyer The Ohio State University

See next page for additional authors

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Repository Citation Siddiqui, Jalal K.; Tikunova, Svetlana B.; Walton, Shane D.; Liu, Bin; Meyer, Meredith; de Tombe, Pieter P.; Neilson, Nathan; Kekenes- Huskey, Peter M.; Salhi, Hussam E.; Janssen, Paul M.L.; Biesiadecki, Brandon J.; and Davis, Jonathan P., "Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of " (2016). Chemistry Faculty Publications. 101. https://uknowledge.uky.edu/chemistry_facpub/101

This Article is brought to you for free and open access by the Chemistry at UKnowledge. It has been accepted for inclusion in Chemistry Faculty Publications by an authorized administrator of UKnowledge. For more information, please contact [email protected]. Authors Jalal K. Siddiqui, Svetlana B. Tikunova, Shane D. Walton, Bin Liu, Meredith Meyer, Pieter P. de Tombe, Nathan Neilson, Peter M. Kekenes-Huskey, Hussam E. Salhi, Paul M.L. Janssen, Brandon J. Biesiadecki, and Jonathan P. Davis

Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I

Notes/Citation Information Published in Frontiers in Physiology, v. 7, 632, p. 1-14.

© 2016 Siddiqui, Tikunova, Walton, Liu, Meyer, de Tombe, Neilson, Kekenes-Huskey, Salhi, Janssen, Biesiadecki and Davis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Digital Object Identifier (DOI) http://doi.org/10.3389/fphys.2016.00632

This article is available at UKnowledge: https://uknowledge.uky.edu/chemistry_facpub/101 ORIGINAL RESEARCH published: 21 December 2016 doi: 10.3389/fphys.2016.00632

Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I

Jalal K. Siddiqui 1, Svetlana B. Tikunova 1, Shane D. Walton 1, Bin Liu 1, Meredith Meyer 1, Pieter P. de Tombe 2, Nathan Neilson 1, Peter M. Kekenes-Huskey 3, Hussam E. Salhi 1, Paul M. L. Janssen 1, Brandon J. Biesiadecki 1 and Jonathan P. Davis 1*

1 Department of Physiology and Biology and the Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA, 2 Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL, USA, 3 Department of Chemistry, University of Kentucky, Lexington, KY, USA

Control of calcium binding to and dissociation from cardiac (TnC) is essential to healthy contraction/relaxation. There are numerous aberrant post-translational modifications and mutations within a plethora of contractile, and even non-contractile, that appear to imbalance this delicate relationship. The Edited by: P. Bryant Chase, direction and extent of