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Summary of Poster Abstracts SUMMARY OF POSTER ABSTRACTS (listed by Session day and Presenter's last name) Sunday Poster Session ECI Poster Page Last Name First Name Institution Abstract Category Title Speaker No. No. University of WIsconsin- Thick/Thin Filament A Composite Approach to Model the Myosin Rod and Andreas Michael 41 71 Madison Structure Thick Filament University of Nevada- Models of Contraction/ Observing the Behavior of a Single Myosin Head within a Brizendine Richard 6 36 Reno Regulation Myosin Filament Moving on Actin Thick/Thin Filament Cardiac Troponin I Serine and Tyrosine Phosphorylation Brundage Elizabeth Ohio State Unviersity X 13 43 Regulation in Striated Muscle Exhibit both Functional and Signaling Integration Increased Myofilament Lattice Spacing and Rate of Force Thick/Thin Filament Chase P. Bryant Florida State University 14 Development (k ) during Ca2+- Activated Cardiac Muscle 44 Regulation in Striated Muscle TR Contraction University of Minnesota- Thick/Thin Filament Effect of RLC Structure on the Myosin Super-relaxed 19 Chu Sami 15 45 Twin Cities Regulation in Striated Muscle State in Cardiac Thick Filament Thick/Thin Filament Regulation of Actin Dynamics at Thin Filament Pointed Colpan Mert University of Arizona 16 46 Regulation in Striated Muscle Ends in the Heart Thick/Thin Filament An N-terminal Extension in Mouse Cardiac Myosin- Colson Brett University of Arizona X 17 47 Regulation in Striated Muscle Binding Protein C Modulates Myofilament Binding Thick/Thin Filament Cryo-EM Structure of Thick Filaments from Drosophila Danesharvar Nadia Florida State University 42 72 Structure Asynchronous Flight Muscle Thick/Thin Filament In Search of Small Molecule Activators of Cardiac Davis Jonathan Ohio State University 18 48 Regulation in Striated Muscle Troponin New phenotyping tools revealed hypertrophic and dilated Thick/Thin Filament Dvornikov Alexey Mayo Clinic 19 cardiomyopathy-like cardiac phenotypes in lamp2 and 49 Regulation in Striated Muscle bag3 knockout zebrafish mutants To study ex vivo mouse working heart at human-like heart Length Dependent Force Feng Hanzhong Wayne State University 1 rate and the effect of N-terminal truncated cardiac 31 Development troponin I on extending Frank-Starling response Sunday Poster Session ECI Poster Page Last Name First Name Institution Abstract Category Title Speaker No. No. Models of Contraction/ Adaptation of mammalian myosin II sequences to body Geeves Michael University of Kent 7 37 Regulation mass University of Maryland- Thick/Thin Filament Myosin Binding Protein-C Slow (sMyBP-C) Function, Geist Janelle 20 50 Baltimore Regulation in Striated Muscle Regulation, and Disease Implications Phosphorylation of cMyBP-C modulates the activation- University of WIsconsin- Thick/Thin Filament Giles Jasmine 21 dependence of unloaded shortening velocity at low levels 51 Madison Regulation in Striated Muscle of Ca2+ activation Illinois Institute of Thick/ Thin Filament Helical Ordering of Myosin Heads in Skeletal Muscle with Gong Henry 43 73 Technology Structure Myosin Inhibitor Treatment Thick/Thin Filament The giant protein titin regulates the length of the striated Granzier Henk University of Arizona 22 52 Regulation in Striated Muscle muscle thick filament 20 Length Dependent Force Role of Cardiac Myosin Binding Protein-C in Regulating Hanft Laurin University of Missouri 2 32 Development the Frank-Starling Relationship Alpha (TPM1.1) and Beta (TPM2.2) Tropomyosins Have Memorial University of Thick/Thin Filament Heeley David 23 Different 53 Newfoundland Regulation in Striated Muscle Biochemical Properties Ex vivo/ in vivo Demonstration of the Frank-Starling Length Dependent Force Henze Marcus MyoKardia 3 Mechanism; Evaluation of the Relative Contribution of the 33 Development Thick and Thin Filaments to Length Dependent Activation Effects of temperature, sarcomere length and RLC Thick/Thin Filament Holohan So-Jin King's College London 24 phosphorylation on the conformation of the myosin motors 54 Regulation in Striated Muscle in relaxed cardiac trabeculae Illinois Institute of Thick/Thin Filament Lattice Arrangement of Myosin Filaments Correlates with Irving Thomas 44 74 Technology Structure Fiber Type inMammalian Skeletal Muscle Models of Contraction/ Control of S100A1 Calcium-Mediated Gating at the C85 Kekenes-Huskey Peter University of Kentucky X 8 38 Regulation Post-translational Modification Site Sunday Poster Session ECI Poster Page Last Name First Name Institution Abstract Category Title Speaker No. No. Thick/Thin Filament Molecular Dynamics Simulations Show Movement of Kiani Farooq Boston University 45 75 Structure Tropomyosin on Filamentous Actin Nebulin Stiffens the Thin Filament and Augments Thick/Thin Filament Kiss Balazs University of Arizona 46 Crossbridge Interaction - An X–Ray Diffraction Study on 76 Structure Intact Muscle Thick/Thin Filament Restoring thick and thin filament interaction with C0-C2 Kumar Mohit University of Cincinnatti 25 55 Regulation in Striated Muscle region of MYBPC3 A New Twist on Tropomyosin Binding to Actin Filaments: Thick/Thin Filament Lehman William Boston University 47 Implications for Thin Filament Assembly and Regulatory 77 Structure Function Thick/Thin Filament Nebulin’s C-Terminus is Necessary for Proper Sarcomeric Li Frank University of Arizona X 26 56 Regulation in Striated Muscle Structure and Function 21 Successful Identification of Cardiac Troponin Calcium Thick/Thin Filament Lindert Steffen Ohio State Unviersity X 48 Sensitizers Using a Combination of Virtual Screening and 78 Structure ROC Analysis of Known Troponin C Binders Thick/Thin Filament Thick filament mechanosensing in skeletal and cardiac Lombardi Vicenzo University of Florence 27 57 Regulation in Striated Muscle muscles: a common mechanism for different tasks Thick/Thin Filament The structure of F-form actin at atomic resolutions: mutual Maeda Yuichiro Nagoya University 49 79 Structure switching between polymorphic transition and ATPase PKC epsilon signaling effect on actin assembly is University of Illinois- Thick/Thin Filament Mkrtschjan Michael 28 diminished in cardiomyocytes when challenged to 58 Chicago Regulation in Striated Muscle additional work in a stiff microenvironment Illinois Institute of Models of Contraction/ Influence of cTn Ca2+ binding properties and cooperative Mijailovich Srboljub 9 39 Technology Regulation mechanisms on cardiac muscle contractile dynamics University of Washington- Models of Contraction/ Overexpression of Rrm2B Elevates Cytosolic dATP and Murray Jason 10 40 Seattle Regulation Cardiac Function Sunday Poster Session ECI Poster Page Last Name First Name Institution Abstract Category Title Speaker No. No. Thick/Thin Filament Myosin-Binding Protein C Isoforms Differentially Regulate Nelson Shane University of Vermont 29 59 Regulation in Striated Muscle Skeletal Muscle Function Strain-dependent Detachment of Cardiac Myosin University of Vermont- Models of Contraction/ Palmer Bradley 11 Crossbridges can Explain the Force Response to a Quick 41 Burlington Regulation Stretch Thick/Thin Filament Effect of Temperature on Thick Filament Based Reconditi Massimo University of Florence 30 60 Regulation in Striated Muscle Regulation of Mammalian Skeletal Muscle Thick/Thin Filament Regulation of Myofilament Force and Loaded Shortening Robinett Joel University of Missouri 31 61 Regulation in Striated Muscle by Myosin Binding Protein-C Thick/Thin Filament Actin Modeling is Critical in Determination of Tropomyosin- Rynkiewicz Michael Boston University 32 62 Regulation in Striated Muscle Actin Energy Landscapes University of Minnesota- Thick/Thin Filament Myosin Orientation in a Muscle Fiber Using Bifunctional 22 Savich Yahor 50 80 Twin Cities Structure Spin Labels with High Angular Resolution Thick/Thin Filament Fropofol Decreases Force Development in Cardiac Schmidt William Johns Hopkins University 33 63 Regulation in Striated Muscle Muscle Memorial University of Thick/Thin Filament The effect of threonine-77 on the cold adaptation of Silva A. Madhushika 34 64 Newfoundland Regulation in Striated Muscle Atlantic salmon tropomyosin (Tpm1.1) Thick/Thin Filament Stability of Myosin Subfragment-2 Modulates the Force Singh Rohit University of Cincinnati 35 65 Regulation in Striated Muscle Produced by Acto-Myosin Interaction of Striated Muscle Understanding the Role of the N-terminus of Myosin Thick/Thin Filament Sitbon Yoel University of Miami 36 Essential Light Chain in Regulating Cardiac Muscle 66 Regulation in Striated Muscle Contraction University of Illinois- Thick/Thin Filament Substrate Stiffness affects Myocyte Organization and Solís Christopher 37 67 Chicago Regulation in Striated Muscle Hypertrophy via PIP2 signaling pathways Thick/Thin Filament Loss of maximum force and speed of contraction in Song Taejeong University of Cincinnati 38 68 Regulation in Striated Muscle MYBPC2 knockout mice Sunday Poster Session ECI Poster Page Last Name First Name Institution Abstract Category Title Speaker No. No. A Specialized Tnc Isoform Enables Muscle Stretch Rensselaer Polytechnic Length Dependent Force Swank Douglas 4 Activation by Reducing Calcium’s Ability to Activate the 34 Institute Development Thin Filament Effects of Myosin Light Chain Phosphorylation on Washington State Length Dependent Force Sarcomere Length-Dependent Β-Myosin Heavy Chain Tanner Bert X 5 35 University Development Kinetics in Myocardial Strips from Propylthioluracil-Treated Rats Models of Contraction/ Structure of F-Actin decorated with the nucleotide-free Taylor Kenneth Florida State
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