Drugs, bytes and Standards: The Future of Radiology

11th Biennial International Symposium of the International Society for Strategic Studies in Radiology IS3R 2015 /The August 27–29, 2015 Scientific Program 1 Imprint Vienna, March 2015 © IS3R, www.is3r.org Coordination: Monika Hierath Design: Sonja Huber, www.diehuber.at Print2 office: druck.at Table of Contents

Letter from the President 4 Letter from the Program Chairs 5 About the IS3R 6 IS3R Organization 7 Program Overview 8 Scientific Program Schedule 9 Venue 13 Practical Information 14 Corporate Members 15

3 Letter from the President

Dear Fellow Members, Colleagues, and Friends,

On behalf of the Executive Board of the In- The program of this year’s symposium is outstanding. I am extremely grateful to Ralph ternational Society for Strategic Studies in Weissleder and all the members of the Program Committee for including truly timely and Radiology, it is my great pleasure to wel- stimulating topics. The large number of panel discussions will enable interactive exchange of come you to the 11th Biennial International opinions between our distinguished members and our industrial partners. It is this exchange Symposium of our Society, August 27–29, to which we are particularly looking forward as it brings a very special flavor to our meetings: 2015, in Amsterdam, the Netherlands. I am the interaction between professionals and companies involved in the field of imaging with extremely pleased that the Executive Board the intention to improve the health and well-being of our patients. On behalf of our entire of IS3R has chosen the capital of my country society, I would like to thank our corporate members for their support and active participa- as the venue of our meeting as I feel that this tion. vibrant city with its international flair com- bining history and tradition with extreme In addition to the program-related interaction, I hope that participants will benefit from tolerance and unconventional thinking fits the possibility to establish new and intensify old relationships, to start new and expand old perfectly with the aims of our Society and friendships, and to experience stimulating conversations in a relaxed environment. But I also with the atmosphere of our meetings. hope that all attendees will take advantage of Dutch hospitality and of the social events that offer a small taste of the as well as providing some food for thought. During the past two years the IS3R has implemented a number of new activities: an “Interim Meeting” was held in December 2014 in Chicago revisiting the developments in our field. This may be the start of an increasingly intense dialogue over the coming years. At the 2015 International Symposium, we, for the first time, welcome a group of young leaders, who we hope will boldly and resolutely guide our profession into a challenging but very promis- ing future. I hope that the information received in our meetings and the contacts with our members and partners from industry will spur their careers so that they may indeed play a meaningful role during the years to come.

As my tenure as President of the IS3R is coming to an end, I would like to express my gratitude to all members of the Executive Board for their support and hard work. A special word of thanks goes to Hedi Hricak, our Past President, on whose wisdom I could always rely with trust and confidence. I would like to congratulate Jonathan Lewin, our incoming President, and wish him a successful term. I am convinced that under his expert and dedicated guidance the IS3R will continue to flourish as a unique platform for high-level strategic exchange in Medical Imaging.

Best wishes,

Gabriel Krestin, MD, PhD IS3R President

4 Letter from the Program Chairs

Dear Colleagues, on behalf of the Program Committee for our This year’s symposium will focus on three distinct areas: imaging and molecular therapeutics, 11th Biennial International Symposium held information technology and standards in radiology. These areas were chosen by the Program this week in Amsterdam, the Netherlands, Committee as they will likely change our specialty over the years to come. Session 1 focuses August 27–29, 2015, it is our pleasure to on “imaging in the molecular era” where molecular diagnostics and targeted therapeutics present the final program and details for the are ever more pervasive. The session also encompasses discussions on unique growth oppor- meeting. We anticipate a very thought-pro- tunities and barriers to commercialization. Session 2 focuses on clinical applications of PET voking meeting as well as lively discussion imaging technologies and their different challenges in penetrating the market while session from our usual gathering of academic, clini- 3 addresses changes and opportunities in healthcare informatics, clinical decision support cal, and industrial leaders. and next generation information technologies in radiology. Finally, session 4 focuses on di- verse restructuring efforts in and affecting radiology as well as the need for more rigorous standards. We hope that you are as excited by these topics as we are as we look forward to engaging discussions.

Two keynote lectures will be presented by distinguished experts to lay the foundation for continued conversations on the future of healthcare, global changes and challenges and scientific opportunities. A hallmark of our meetings is time for panels and interactive discus- sions to facilitate the exchange of ideas. We have tailored the program to ensure that there is sufficient time after each session for these discussions. As in the past, we will prepare a summary of the meeting outcomes which will be distributed to our members.

We would like to thank the entire Program Committee for its tireless efforts in organizing this year’s meeting. Together, we would also like to thank the IS3R office staff and the rest of the IS3R board for their support in preparing for the meeting. Last but not least, we would like to thank all the invited speakers, moderators, and panelists for their invaluable contributions. It is their input that will hopefully make this meeting a huge success. We look forward to welcoming you in Amsterdam.

With best regards,

Ralph Weissleder, MD, PhD gabriel Krestin, MD, PhD hedvig Hricak, MD, PhD Chair of the President and local host of Co-Chair of the Program Committee the Program Committee Program Committee

5 ABOUT THE IS3R

Mission of the IS3R Committees

The International Society for Strategic Studies in Radiology is a non-political, not-for-profit PUBLICATIONs COMMITTEE organization whose purpose is to define and investigate strategic, scientific and economic Chair issues of global importance to the field of radiology. Christian Herold (Vienna/AT) Members By forming a partnership between academia and industry, the Society seeks to anticipate Byung Ihn Choi (Seoul/KR) national and global developments in radiology and allied fields, define areas of common in- Adrian K. Dixon (Cambridge/UK) terest to both partners, and encourage cooperation. It aims to communicate important issues Hedvig Hricak (New York/US) to radiologists, physicians in other medical fields, industry and governments, and to influence Gabriel P. Krestin (Rotterdam/NL) healthcare management and the flow of financial and human resources into the scientific and Jonathan S. Lewin (Baltimore/US) strategic fields most likely to advance biomedical imaging and patient care. Stefan Schönberg (Mannheim/DE) James H. Thrall (Boston/US)

MEMBERSHIP & NOMINATING COMMITTEE Chair IS3R Executive Board Maximilian Reiser (Munich/DE) Co-Chair President By-Laws & Rules Committee Herbert Y. Kressel (Boston/US) Gabriel P. Krestin (Rotterdam/NL) Chair: James Thrall (Boston/US) Members Boris Brkljacic (Zagreb/HR) Past President Corporate Advisory BOARD Bruce Hillman (Charlottesville/US) Hedvig Hricak (New York/US) Chair: William G. Bradley (San Diego/US) Pek-Lan Khong (Pokfulam Hong Kong/CN) Norbert J. Pelc (Stanford/US) Founding President Program Committee Mitchell D. Schnall (Philadelphia/US) Alexander R. Margulis (New York/US) Chair: Ralph Weissleder (Boston/US) Valentin Sinitsyn (Moscow/RU)

President-Elect COMPLIANCE COMMITTEE BY-LAWS & RULES COMMITTEE Jonathan S. Lewin (Baltimore/US) Chair: Guy Frija (Paris/FR) Chair James Thrall (Boston/US) Vice President AWARDS AND HONOURS COMMITTEE Co-Chair Xiaoyuan Feng (Shanghai/CH)) Chair: Hedvig Hricak (New York/US) Stefan Schönberg (Mannheim/DE) Members Treasurer YOUNG LEADERS CLUB COMMITTEE Dieter Enzmann (Los Angeles/US) Luis Donoso (Barcelona/ES) Chair: Carlo Catalano (Rome/IT) Moshe Graif (Tel Aviv/IL) Sachio Kuribayashi (Tokyo/JP) Secretary EXECUTIVE BOARD Members at Large András Palkó (Szeged/HU) Norman J. Beauchamp (Washington/US) Ronald Arenson (San Francisco/US) Boris Brkljacic (Zagreb/HR) CORPORATE ADVISORY BOARD Publications Committee Giovanni Cerri (Sao Paulo/Brazil) Chair Chair: Christian Herold (Vienna/AT) Sanjiv S. Gambhir (Stanford/US) William G. Bradley (San Diego/US) Stefan Schönberg (Mannheim/DE) Co-Chair Membership & Nominating Committee Kazuro Sugimura (Kobe/JP) Bernd K. Hamm (Berlin/DE) Chair: Maximilian Reiser (Munich/DE) Members Norman J. Beauchamp (Seattle/US) James A. Brink (Boston/US)

6 IS3R Organization

Administration

Byung Ihn Choi (Seoul/KR) AWARDS AND HONOURS COMMITTEE IS3R – European Office Luis Donoso (Barcelona/ES) Chair Society and Symposium Secretariat Xiaoyuan Feng (Shanghai/CH) Hedvig Hricak (New York/US) Monika Hierath & Katharina Krischak Christian Herold (Vienna/AT) Members Neutorgasse 9/2, 1010 Vienna, AUSTRIA Hedvig Hricak (New York/US) Adrian K. Dixon (Cambridge/UK) Phone: +43-1-533-4064-20 Valerie Jackson (Indianapolis/US) Philippe Grenier (Paris/FR) Fax: +43-1-535-7037 Gabriel P. Krestin (Rotterdam/NL) Gabriel P. Krestin (Rotterdam/NL) E-mail: [email protected] Jonathan S. Lewin (Baltimore/US) Barbara McNeil (Boston/US) Carolyn C. Meltzer (Atlanta/US) IS3R – US Office Maximilian F. Reiser (Munich/DE) YOUNG LEADERS CLUB COMMITTEE Society Secretariat Chair Pamela F. Mechler PROGRAM COMMITTEE Carlo Catalano (Rome/IT) 1891 Preston White Drive Chair Co-Chair Reston, VA 20191, USA Ralph Weissleder (Boston/US) Hedvig Hricak (New York/US) Phone: +1-703-716-7545 Co-Chairs Members Fax: +1-703-716-4487 Hedvig Hricak (New York/US) N. Reed Dunnick (Ann Arbor /US E-mail: [email protected] Gabriel P. Krestin (Rotterdam/NL) Xiaoyuan Feng (Shanghai/CN) Members Christian J. Herold (Vienna/AT) www.is3r.org James A. Brink (Boston/US) Herbert Y. Kressel (Boston/US) William R. Brody (La Jolla/US) Gabriel P. Krestin (Rotterdam/NL) R. Nick Bryan (Philadelphia/US) Maximilian F. Reiser (Munich/DE) Philippe Grenier (Paris/FR) Thomas M. Grist (Madison/US) Christian J. Herold (Vienna/AT) Zhengyu Jin (Beijing/CN) Jonathan S. Lewin (Baltimore/US) Maximilian F. Reiser (Munich/DE) Hans Ringertz (Linköping/SE) Stefan Schönberg (Mannheim/DE) Markus Schwaiger (Munich/DE) James H. Thrall (Boston/US) Elias Zerhouni (Baltimore/US)

COMPLIANCE COMMITTEE Chair Guy Frija (Paris/FR) Co-Chair Kazuro Sugimura (Kobe/JP) Members Ronald Arenson (San Francisco/US) Lorenzo Bonomo (Rome/IT) Bernd K. Hamm (Berlin/DE) Hiroshi Honda (Fukuoka/JP) Jonathan S. Lewin (Baltimore/US)

7 PROGRAM OVERVIEW

Thursday, August 27* Friday, August 28* Saturday, August 29*

07:30 Registration 08:30 Session III: Healthcare IT 08:30 Session IV (con.): 08:30 Welcome and Opening Remarks Standards and Changes in 10:30 Break Radiology 09:00 Keynote Address 1 11: 00 P anel Discussion: Next gen 10:30 Break 09:45 Session I: Molecular informatics and clinical Therapies and Imaging decision support 11: 00 P anel Discussion: Standardization of imaging 10:25 Break 12:00 lunch biomarkers across different vendors 10:55 S ession I (con.): Molecular 13:00 Panel Discussion (con.): Next Therapies and Imaging gen informatics and clinical 12:30 Summary and Closing decision support 11:55 lunch 14:00 Keynote Address 2 13:00 Panel Discussion: Companion 13:00 Farewell Lunch imaging diagnostics (CID) 14:45 Break

14:00 Break 15:15 S ession IV: Standards and Changes in Radiology 14:30 S ession II: PET Technologies, MRI-PET P anel Discussion: Changing times of Academic/industry 16:00 Adjourn relationships

16:30 Panel Discussion: 16:00 IS3R General Assembly Non-physician support (members only) 17:45 Adjourn

19:30 Social Event at Rosarium 19:30 Social Event at National Maritime Museum

*All sessions take place in the Council Chamber.

8 SCIENTIFIC PROGRAM Schedule

Thursday, August 27

OPENING SESSION 13:00 PANEL DISCUSSION: Companion SESSION II: PET TECHNOLOGIES, imaging diagnostics (CID) MRI-PET 08:30 Opening Remarks and Welcome Chairs: O. Clément, Chairs: O. Ratib, C. Meltzer, P. Khong 09:00 Keynote address: The future B. Hillman, L. Tan of health-care from company 14:30 What are the niches for MRI-PET? perspective a. Is there a business for CID g. von Schulthess F. van Houten and how do we get them 14:45 What are the European challenges reimbursed? for PET (incl. regulatory hurdles for Session I: MOLECULAR THERAPIES J. Debatin new tracers)? AND IMAGING b. CID development from a pharma C. Claussen Chairs: B. Hamm, H. Honda perspective? 15:00 P ET neuroincubator model – E. Zerhouni (tbc) enabling the field by making PET 09:45 The growing field of theranostics c. CID development from a pharma tracers available through a self- and companion imaging diagnostics perspective? sustaining initiative m. Schwaiger M. Mintun (tbc) g. Brophy 10:05 Challenges in imaging signature d. CID development from a dx 15:15 Siemens: 15 years after the pathways (and in tracking cells such pharma perspective? introduction of PET/CT: lessons as stem cells or immune cells) N.N. learned – utilization and S. Gambhir e. CID development from a dx dissemination pharma perspective? B. Fünfstück 10:25 Break N.N. 15:30 Toshiba: 15 years after the f. CID from an imaging introduction of PET/CT: lessons 10:55 Interventional approaches for perspective? learned – utilization and molecular testing N.N. dissemination (tbc) R. Weissleder g. NIH perspectives N.N. 11:15 Imaging in drug development: R. Pettigrew 15:30 Philips: 15 years after the patient selection or efficacy introduction of PET/CT: lessons H. Hricak 14:00 Break learned – utilization and 11:35 Imaging and in vitro biomarkers: dissemination challenges and opportunities for h. Pien integrated diagnostics (academic perspective) 16:00 Adjourn g. Krestin

11:55 lunch 16:00 IS3R General Assembly (members only)

19:30 Social Event at Rosarium Buses will depart from Sofitel Legend The Grand at 18:30

9 SCIENTIFIC PROGRAM Schedule

Friday, August 28

SESSION III: HEALTHCARE IT 3. What are the challenges 16:45 PANEL DISCUSSION 2: Chairs: M. Reiser, P. Aspelin, developing/implementing Next Non-physician support R. Garcia-Monaco Generation IT? Chairs: L. Bonomo, B. Choi, W. Kalender, M. Graif H. Gharbi 08:30 Update on clinical decision support J. Brink 14.00 Key note address: TBC a. Who/what are the drivers 08.50 H ow will “big data” affect radiology J. Penninger (expand access and decrease (research/analytics)? costs) R. Arenson 14:45 Break S. Golding 09:10 What does image mining offer? b. Can computers be a radiologist’s Why should we care? SESSION IV: STANDARDS AND assistant (clinical decision support T. Grist CHANGES IN RADIOLOGY software for neuroradiology; 09:30 How will Apple and Google health- a start-up perspective)? care entries change our space? 15:15 PAN EL DISCUSSION 1: Changing R. Bryan J. Lewin times of Academic/industry c. Outsourcing to other countries 09:50 Opportunities for business analytics relationships A. Dixon software Chairs: N. Dunnick, B. Brkljacic, d. Physician extenders D. Enzmann S. Ternovoy (tbc) K. Soyebi 10:10 Large scale, vender neutral solutions m. Prokop a. How are the relationships 17:45 Adjourn changing? 10:30 Break P. Grenier b. What has worked and what 11: 00 PAN EL DISCUSSION: Next gen hasn‘t? 19:30 SOCIAL EVENT at National Maritime informatics and clinical N. Pelc Museum decision support c. New models (industry Ship will depart from Sofitel Legend Chairs: R. Günther (tbc), perspective: Siemens) The Grand at 18:30 V. Jackson, S. Schönberg H. Requardt d. New models (industry 1. What’s on the horizon beyond perspective: Philips) PACS: D. Olego a. Cloud Imaging enabling e. New models (academic breakthrough analytics and perspective Europe) boundaryless collaboration C. Catalano J. DeWitte f. New models (academic b. New IT developments perspective Russia) G. Sorensen V. Sinitsyn g. New models (academic 12:00 lunch perspective Brazil) G. Cerri 13:00 2. What are the opportunities and h. New models (academic barriers to broad adoption of perspective Asia) clinical decision support? Z. Jin, X. Feng, K. Sugimura S. Seltzer, L. Donoso, G. Frija

10 SCIENTIFIC PROGRAM Schedule

Saturday, August 29

SESSION IV (con.): STANDARDS AND 11: 00 PAN EL DISCUSSION 3: CHANGES IN RADIOLOGY Standardization of imaging Chairs: C. Herold, D. Kim, S. Baum biomarkers across different vendors 08:30 Partnering and interdisciplinary Chairs: J. Dai, D. Le Bihan interactions in radiology (departments vs. service a. FDA requirements for lines/centers) and the importance of quantitative biomarker approval multidisciplinary conferences D. Sullivan W. Bradley b. How do we implement 08:50 Conflict of interest and compliance. standardized biomarkers How does it work with increasing M. Schnall pressure to enter academic/private c. Implementation of standards sector relationships? across different institutions H. Kressel R. Evens 09:10 TBC d. Siemens B. McNeil N.N. 09:30 ACOs in the US (i.e. population e. Bayer health management); Imaging 3.0 E. Puchert (value vs. volume). J. Thrall 12.30 SUMMARY and CLOSING 09:50 Companies buying hospitals and R. Weissleder, G. Krestin practices: what is happening in Europe? A. Palkó 10:10 Rising cost of imaging and 13:00 FAREWELL LUNCH equipment. How to control costs g. Rubin

10:30 Break

11 12 VENUE

Hotel Information

Sofitel Legend The Grand 197 1012 EX Amsterdam, Netherlands Phone: (+31)20 / 5553111

Fax: (+31)20/5553222

Email: [email protected]

Geldersekade

Web: www.sofitel-legend-thegrand.com Anne Frank‘s House

Oosterdok

Sofitel Legend The Grand Amsterdam is a Oudezijds Voorburgwal

Waalseilandsgracht

five-star hotel in the heart of the city of- Royal Palace

fering a unique historical ambiance. From Sofitel Legend The Grand

th a 15 -century convent to royal lodgings to Oude Schans Dutch Admiralty headquarters to the city Kloveniersburgwal hall of Amsterdam, the hotel boasts a rich history. The venue is within walking distance

of Amsterdam’s major landmarks, including the Van Gogh Museum, the Royal Palace, binnenAmstel

Anne Frank’s House, and the new Hermit - age Amsterdam. Hermitage Amsterdam binnenAmstel

Amstel

Van Gogh Museum

13 PRACTICAL INFORMATION

Practical Information

Certificate of Attendance or their stay in Amsterdam. Participants and Registration Participants who would like to receive a accompanying persons should ensure that Staff at the symposium registration desk will certificate certifying their attendance at the their own personal health, accident and/or be available on Wednesday evening from symposium are encouraged to request one travel insurance are up-to-date and valid for 15:00–17:00, as well as during the sympo- from the registration desk (located in the use in Amsterdam. sium hours from Thursday to Saturday. They lobby) before adjournment on Saturday. will assist you with local information for Meals sightseeing in Amsterdam, booking optional Credit Cards/Currency Exchange Buffet breakfast is included at the Sofitel tours, or any questions regarding your ac- The hotel reception provides currency ex- Legend The Grand. Business lunch buffet commodations. change up to $500. The closest exchange and coffee breaks for all participants will be office is located at Amsterdam Central Sta- provided. Thank you for your understanding Smoking Policy tion (10 min walk). The nearest ATM can be that the IS3R does not provide lunch and cof- The symposium meeting sessions are non- found in (2 min walk). Major fee breaks for accompanying persons. smoking. However, smoking is permitted in Credit Cards are accepted. the hotel’s cigar lounge. Official Language Insurance English (no translation of the meeting will be Speakers‘ Desk Neither the IS3R nor the symposium organi- provided). Speakers are kindly requested to upload zers can accept liability for personal injury, or their presentation at the Speakers‘ Desk at loss/damage to property, personal or other- Recording least 90 minutes before the session starts. wise, belonging to meeting participants or Audio or video recording any part of the accompanying persons, either during or as symposium without prior express permission a result of the symposium or during all tours is prohibited.

Social Evening Events

Wednesday 19:00–20:30. Thursday at 18:30 Friday at 19:30 Welcome reception at the Sofitel Legend Cocktails and dinner will be held at Rosarium, The IS3R 11th Anniversary Celebration and The Grand. Drinks and light hors d‘oeuvres which is located in the middle of the green Gold Medal Dinner will be held at the Na- will be served. environment of the beautiful Amstelpark in tional Maritime Museum. The reception at Dress code: Smart casual the south of Amsterdam. The restaurant is the museum will be preceded by a boat ride known for its innovative cuisine and superb along the 17th-century of Amsterdam. atmosphere. The comfortable and modern Located at the waterfront, the museum is interior and the splendid view of the won- housed in a former naval storehouse const- derful rose garden allow for an exceptional ructed in 1656 and is a reminder of how sig- dining experience. nificantly Dutch culture has been shaped by Dress code: Business casual attire, jacket not the sea. Today, the architecture blends histo- required ric architecture with contemporary features such as the magnificent inner courtyard with its spectacular glass roof while retaining all the maritime allure of days gone by. Dress code: Dinner attire, jacket required

Please note that pre-registration to all social events is required. Information on the registration process will be provided shortly.

14 CORPORATE MEMBERS

Platinum General Electric Healthcare Technologies Philips Medical Systems Siemens Medical Solutions Toshiba America Medical Systems

Gold Affidea Alliance Medical Group Bayer Healthcare LL C Bracco Diagnostics Inc. Hologic, Inc. Laboratoire Guerbet, SA

Silver Agfa-Gevaert, N.V. Carestream Health Elekta Navidea Biopharmaceuticals Sirtex Medical Europe GmbH

15 11th Biennial International Symposium of the International Society for Strategic Studies in Radiology IS3R 2015 Amsterdam/The Netherlands August 27–29, 2015 Preliminary Program 16