DOCSLIB.ORG

Causative Nematode of Human Anisakiasis , a Anisakis Simplex

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Causative Nematode of Human Anisakiasis , a Anisakis Simplex Purification and Cloning of an Apoptosis-Inducing Protein Derived from Fish Infected with Anisakis simplex, a Causative Nematode of Human Anisakiasis This information is current as of September 23, 2021. Sang-Kee Jung, Angela Mai, Mitsunori Iwamoto, Naoki Arizono, Daisaburo Fujimoto, Kazuhiro Sakamaki and Shin Yonehara J Immunol 2000; 165:1491-1497; ; doi: 10.4049/jimmunol.165.3.1491 Downloaded from http://www.jimmunol.org/content/165/3/1491 References This article cites 25 articles, 10 of which you can access for free at: http://www.jimmunol.org/ http://www.jimmunol.org/content/165/3/1491.full#ref-list-1 Why The JI? Submit online. • Rapid Reviews! 30 days* from submission to initial decision • No Triage! Every submission reviewed by practicing scientists by guest on September 23, 2021 • Fast Publication! 4 weeks from acceptance to publication *average Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2000 by The American Association of Immunologists All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. Purification and Cloning of an Apoptosis-Inducing Protein Derived from Fish Infected with Anisakis simplex, a Causative Nematode of Human Anisakiasis1 Sang-Kee Jung2*† Angela Mai,*† Mitsunori Iwamoto,* Naoki Arizono,‡ Daisaburo Fujimoto,§ Kazuhiro Sakamaki,† and Shin Yonehara2† While investigating the effect of marine products on cell growth, we found that visceral extracts of Chub mackerel, an ocean fish, had a powerful and dose-dependent apoptosis-inducing effect on a variety of mammalian tumor cells. This activity was strikingly dependent on infection of the C. mackerel with the larval nematode, Anisakis simplex. After purification of the protein responsible for the apoptosis-inducing activity, we cloned the corresponding gene and found it to be a flavoprotein. This protein, termed apoptosis-inducing protein (AIP), was also found to possess an endoplasmic reticulum retention signal (C-terminal KDEL se- Downloaded from quence) and H2O2-producing activity, indicating that we had isolated a novel reticuloplasimin with potent apoptosis-inducing activity. AIP was induced in fish only after infection with larval nematode and was localized to capsules that formed around larvae to prevent their migration to host tissues. Our results suggest that AIP may function to impede nematode infection. The Journal of Immunology, 2000, 165: 1491–1497. lterations in cell survival and growth contribute to the with apoptosis-inducing activity, and therefore has potential im- http://www.jimmunol.org/ pathogenesis of a number of human diseases, including portance in host defense system against invading parasites. A cancer, infection, autoimmune diseases, and neurode- generative disorders (1). Apoptosis can be triggered by a variety of Materials and Methods extrinsic and intrinsic signals. Purification of AIP During screening of biological response modifiers, particularly All packed columns used for purification were from Pharmacia (Piscat- those regulating cell growth, from marine fishes and plants, we away, NJ). All fractions were assayed for apoptosis-inducing activity, and observed that several mammalian tumor cells exposed to extracts all procedures were done at 4°C. Lyophilized visceral extracts from Ani- from visceral organs of Chub mackerel underwent morphological sakis simplex-infected C. mackerel were dissolved in 100 mM Tris-HCl changes resembling those of apoptosis. This activity was heat, pH, (pH 7.5) and centrifuged at 27,000 ϫ g for 30 min. The supernatant was by guest on September 23, 2021 and protease sensitive, and Fas and TNF receptor independent (our subjected to ammonium sulfate fractionation, and the precipitate obtained at 55–95% saturation with ammonium sulfate was dissolved in 20 mM unpublished observations). Tris-HCl (pH 7.5), and applied to a HiLoad 16/60 Superdex 200 pg gel- In the current study, we report the purification, cDNA cloning, filtration column in the same buffer. Fractions that contained apoptosis- and characterization of this protein factor designated as apoptosis- inducing activity (active fractions) were pooled, applied to a Con A-Sepha- ␣ inducing protein (AIP).3 AIP was found to be induced in fish by rose column, eluted with 0.5 M methyl- -D-mannopyranoside, and concentrated by ultrafiltration with a 50-kDa molecular mass cutoff mem- infection with larval nematode, and possesses the basic dinucle- brane. Concentrated material was applied to a HiLoad Superdex 200 col- otide-binding motif and COOH-terminal endoplasmic reticulum umn equilibrated with buffer A (20 mM bis-Tris, pH 6.4, 100 mM NaCl) (ER) retention signal, indicating that it is a novel structural and and eluted with the same buffer. Active fractions were applied to a Mono functional reticuloplasmin. Evidence is presented that AIP is se- Q HR 5/5 column equilibrated with buffer A and eluted with a linear gra- creted from the ER in vivo and in vitro as a functional molecule dient up to 1 M NaCl. Active fractions were concentrated, applied to a Superdex 200 HR 10/30 gelfiltration column equilibrated with PBS, and eluted with the same buffer. Active fractions were sterilized and stored in small portions at Ϫ80°C. The concentration of protein was determined by *M, F, L Science Center, Tensei-suisan Co., Karatsu, Saga, Japan; †Institute for Virus the bicinchoninic acid assay (Pierce, Rockford, IL) with BSA as a standard. Research, Kyoto University, Shogoin, Sakyo-ku, Kyoto, Japan; ‡Department of Med- ical Zoology, Kyoto Prefectural University of Medicine, Kawaramachi-hirokoji, cDNA cloning Kyoto, Japan; and §Department of Applied Biological Science, Faculty of Agricul- ture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan To determine the N-terminal sequence, two protein bands of 62 and 64 kDa were resolved by SDS-PAGE, transferred to a polyvinylidene difluoride Received for publication January 18, 2000. Accepted for publication May 19, 2000. membrane, and submitted for sequence analysis. To determine the internal The costs of publication of this article were defrayed in part by the payment of page sequence, the Coomassie blue-stained protein band was excised from the charges. This article must therefore be hereby marked advertisement in accordance SDS-PAGE gel. After in-gel digestion with V8 protease, the sequences of with 18 U.S.C. Section 1734 solely to indicate this fact. four peptides were determined. The following peptide sequences and res- 1 Sequence data have been submitted to the European Molecular Biology Laboratory idue numbers are based on the derived amino acid sequence of the AIP (EMBL) databases under accession number AJ400871. gene (residues 1–524): EHLADXLEDKDYDTLLQTLD (residues 31–50, 2 Address correspondence and reprint requests to Dr. Sang-Kee Jung, M, F, L Science N-terminal sequences of two polypeptides), FVMTDDNTFY (residues Center, Tensei-suisan Co., 1-25 Nakase-dori, Karatsu, Saga 847-0193, Japan; or Dr. 138–147), MIYDQADV (residues 246–253), AFLSVLDVP (residues Shin Yonehara, Institute for Virus Research, Kyoto University, Shogoin, Sakyo-ku, 272–280), and SLLFLGASDE (residues 408–417). Single-letter abbrevi- Kyoto 606-8507, Japan. E-mail address: [email protected] or syonehar@ ations for the amino acid residues are as follows: A, Ala; C, Cys; D, Asp; virus.kyoto-u.ac.jp E, Glu; F, Phe; G, Gly; H, His; I, Ile; K, Lys; L, Leu; M, Met; N, Asn; P, 3 Abbreviations used in this paper: AIP, apoptosis-inducing protein; BiP, Ig heavy Pro; Q, Gln; R, Arg; S, Ser; T, Thr; V, Val; W, Trp; and Y, Tyr. X, chain binding protein; ER, endoplasmic reticulum; Fig 1, IL-4-induced mouse B cell Indicates unidentified amino acid. Two degenerate primers corresponding gene; LAO, L-amino acid oxidase; OPD, o-phenylenediamine dihydrochloride. to the peptide sequences EHLADCLEDKDYDTLLQTLD and MIY Copyright © 2000 by The American Association of Immunologists 0022-1767/00/$02.00 1492 AIP, A NOVEL INFECTION-DEPENDENT APOPTOSIS-INDUCING PROTEIN DQADV were designed: GA(A/G)GA(C/T)AA(A/G)GA(C/T)TA(C/ with the equal volume of2NH2SO4, and the amount of H2O2 production T)GA(C/T)AC and TC(A/C/G/T)GC(C/T)TG(A/G)TC(A/G)TA(A/G)TA was determined by comparison with a standard curve that had been gen- CAT, and used as primers for RT-PCR. Total RNA was prepared from the erated using fresh dilutions of stock H2O2. dissected capsule of larva-infected C. mackerel by homogenization in TRIZOL (Life Technologies, Grand Island, NY) and used to synthesize the Plasmid construction and transfections first-strand cDNA with Superscript reverse transcriptase (Life Technolo- gies). Poly(A) RNA was isolated from total RNA by using oligo(dT) Full-length AIP cDNA was introduced into a mammalian expression plas- mRNA purification kit (Pharmacia) and used to construct the capsule mid pEF-BOS (2) (pEF-AIP). To exchange signal sequence of AIP for cDNA library (SuperScript plasmid system for cDNA synthesis and plas- mammalian signal sequence, the region coding aa 31–524 and stop codon mid cloning; Life Technologies). RT-PCR conditions used were 94°C for was introduced into a SfiI site of pSecTag2 vector (Invitrogen) (pSec-AIP). 1 min, 56°C for 1 min, and 72°C for 2 min (35 cycles). A 644-bp PCR pEF-AIP and pSec-AIP were transfected into Cos-7 cells using a Bio-Rad product was obtained and subsequently sequenced after subcloning into the (Richmond, CA) Gene Pulser apparatus and into NIH3T3 cells by the pCR vector using the TA cloning kit (Invitrogen, San Diego, CA).
Load more

Recommended publications
  • Gnathostoma Spinigerum Was Positive
    Department Medicine Diagnostic Centre Swiss TPH Winter Symposium 2017 Helminth Infection – from Transmission to Control Sushi Worms – Diagnostic Challenges Beatrice Nickel Fish-borne helminth infections Consumption of raw or undercooked fish - Anisakis spp. infections - Gnathostoma spp. infections Case 1 • 32 year old man • Admitted to hospital with severe gastric pain • Abdominal pain below ribs since a week, vomiting • Low-grade fever • Physical examination: moderate abdominal tenderness • Laboratory results: mild leucocytosis • Patient revealed to have eaten sushi recently • Upper gastrointestinal endoscopy was performed Carmo J, et al. BMJ Case Rep 2017. doi:10.1136/bcr-2016-218857 Case 1 Endoscopy revealed 2-3 cm long helminth Nematode firmly attached to / Endoscopic removal of larva with penetrating gastric mucosa a Roth net Carmo J, et al. BMJ Case Rep 2017. doi:10.1136/bcr-2016-218857 Anisakiasis Human parasitic infection of gastrointestinal tract by • herring worm, Anisakis spp. (A.simplex, A.physeteris) • cod worm, Pseudoterranova spp. (P. decipiens) Consumption of raw or undercooked seafood containing infectious larvae Highest incidence in countries where consumption of raw or marinated fish dishes are common: • Japan (sashimi, sushi) • Scandinavia (cod liver) • Netherlands (maatjes herrings) • Spain (anchovies) • South America (ceviche) Source: http://parasitewonders.blogspot.ch Life Cycle of Anisakis simplex (L1-L2 larvae) L3 larvae L2 larvae L3 larvae Source: Adapted to Audicana et al, TRENDS in Parasitology Vol.18 No. 1 January 2002 Symptoms Within few hours of ingestion, the larvae try to penetrate the gastric/intestinal wall • acute gastric pain or abdominal pain • low-grade fever • nausea, vomiting • allergic reaction possible, urticaria • local inflammation Invasion of the third-stage larvae into gut wall can lead to eosinophilic granuloma, ulcer or even perforation.
    [Show full text]
  • The Functional Parasitic Worm Secretome: Mapping the Place of Onchocerca Volvulus Excretory Secretory Products
    pathogens Review The Functional Parasitic Worm Secretome: Mapping the Place of Onchocerca volvulus Excretory Secretory Products Luc Vanhamme 1,*, Jacob Souopgui 1 , Stephen Ghogomu 2 and Ferdinand Ngale Njume 1,2 1 Department of Molecular Biology, Institute of Biology and Molecular Medicine, IBMM, Université Libre de Bruxelles, Rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium; [email protected] (J.S.); [email protected] (F.N.N.) 2 Molecular and Cell Biology Laboratory, Biotechnology Unit, University of Buea, Buea P.O Box 63, Cameroon; [email protected] * Correspondence: [email protected] Received: 28 October 2020; Accepted: 18 November 2020; Published: 23 November 2020 Abstract: Nematodes constitute a very successful phylum, especially in terms of parasitism. Inside their mammalian hosts, parasitic nematodes mainly dwell in the digestive tract (geohelminths) or in the vascular system (filariae). One of their main characteristics is their long sojourn inside the body where they are accessible to the immune system. Several strategies are used by parasites in order to counteract the immune attacks. One of them is the expression of molecules interfering with the function of the immune system. Excretory-secretory products (ESPs) pertain to this category. This is, however, not their only biological function, as they seem also involved in other mechanisms such as pathogenicity or parasitic cycle (molting, for example). Wewill mainly focus on filariae ESPs with an emphasis on data available regarding Onchocerca volvulus, but we will also refer to a few relevant/illustrative examples related to other worm categories when necessary (geohelminth nematodes, trematodes or cestodes).
    [Show full text]
  • 84364615004.Pdf
    Biomédica ISSN: 0120-4157 ISSN: 2590-7379 Instituto Nacional de Salud Bolaños, Fernando; Jurado, Leonardo F.; Luna-Tavera, Rina L.; Jiménez, Jaime M. Abdominal angiostrongyliasis, report of two cases and analysis of published reports from Colombia Biomédica, vol. 40, no. 2, 2020, pp. 233-242 Instituto Nacional de Salud DOI: 10.7705/biomedica.5043 Available in: http://www.redalyc.org/articulo.oa?id=84364615004 How to cite Complete issue Scientific Information System Redalyc More information about this article Network of Scientific Journals from Latin America and the Caribbean, Spain and Journal's webpage in redalyc.org Portugal Project academic non-profit, developed under the open access initiative Biomédica 2020;40:233-42 Abdominal angiostrongyliasis in Colombia doi: https://doi.org/10.7705/biomedica.5043 Case report Abdominal angiostrongyliasis, report of two cases and analysis of published reports from Colombia Fernando Bolaños1,2, Leonardo F. Jurado3,4,5, Rina L. Luna-Tavera1, Jaime M. Jiménez1 1 Departamento de Patología, Hospital Universitario Hernando Moncaleano Perdomo, Neiva, Colombia 2 Departamento de Patología, Hospital Universitario Departamental de Nariño, Pasto, Colombia 3 Departamento de Patología y Laboratorios, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá, D.C., Colombia 4 Departamento de Microbiología, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, D.C., Colombia 5 Facultad de Medicina, Fundación Universitaria Sanitas, Bogotá, D.C., Colombia Abdominal angiostrongyliasis is a parasitic zoonosis, endemic in the American continent. Its etiological agent is Angiostrongylus costaricensis, a nematode whose definitive hosts are rats and other rodents and the intermediate hosts, slugs. Mammals acquire the infection by consuming vegetables contaminated with L3 larvae.
    [Show full text]
  • Baylisascariasis
    Baylisascariasis Importance Baylisascaris procyonis, an intestinal nematode of raccoons, can cause severe neurological and ocular signs when its larvae migrate in humans, other mammals and birds. Although clinical cases seem to be rare in people, most reported cases have been Last Updated: December 2013 serious and difficult to treat. Severe disease has also been reported in other mammals and birds. Other species of Baylisascaris, particularly B. melis of European badgers and B. columnaris of skunks, can also cause neural and ocular larva migrans in animals, and are potential human pathogens. Etiology Baylisascariasis is caused by intestinal nematodes (family Ascarididae) in the genus Baylisascaris. The three most pathogenic species are Baylisascaris procyonis, B. melis and B. columnaris. The larvae of these three species can cause extensive damage in intermediate/paratenic hosts: they migrate extensively, continue to grow considerably within these hosts, and sometimes invade the CNS or the eye. Their larvae are very similar in appearance, which can make it very difficult to identify the causative agent in some clinical cases. Other species of Baylisascaris including B. transfuga, B. devos, B. schroeder and B. tasmaniensis may also cause larva migrans. In general, the latter organisms are smaller and tend to invade the muscles, intestines and mesentery; however, B. transfuga has been shown to cause ocular and neural larva migrans in some animals. Species Affected Raccoons (Procyon lotor) are usually the definitive hosts for B. procyonis. Other species known to serve as definitive hosts include dogs (which can be both definitive and intermediate hosts) and kinkajous. Coatimundis and ringtails, which are closely related to kinkajous, might also be able to harbor B.
    [Show full text]
  • Agent for Expelling Parasites in Humans, Animals Or Birds
    (19) TZZ Z_T (11) EP 2 496 089 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: A01N 65/00 (2009.01) A01N 65/10 (2009.01) 22.02.2017 Bulletin 2017/08 A61K 36/23 (2006.01) A01P 5/00 (2006.01) (21) Application number: 10803029.7 (86) International application number: PCT/BE2010/000077 (22) Date of filing: 05.11.2010 (87) International publication number: WO 2011/054066 (12.05.2011 Gazette 2011/19) (54) AGENT FOR EXPELLING PARASITES IN HUMANS, ANIMALS OR BIRDS MITTEL ZUR ABWEISUNG VON PARASITEN BEI MENSCHEN, TIEREN ODER VÖGELN AGENT POUR EXPULSER DES PARASITES CHEZ DES HUMAINS, DES ANIMAUX OU DES OISEAUX (84) Designated Contracting States: (56) References cited: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB • RAMADAN NASHWA I ET AL: "The in vitro effect GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO of assafoetida on Trichomonas vaginalis", PL PT RO RS SE SI SK SM TR JOURNAL OF THE EGYPTIAN SOCIETY OF PARASITOLOGY, EGYPTIAN SOCIETY OF (30) Priority: 06.11.2009 BE 200900689 PARAS1TOLOGY, CAIRO, EG, vol. 33, no. 2, 1 August 2003 (2003-08-01) , pages 615-630, (43) Date of publication of application: XP009136264, ISSN: 1110-0583 12.09.2012 Bulletin 2012/37 • DATABASE MEDLINE [Online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, (73) Proprietors: US; December 2004 (2004-12), RAMADAN • MEIJS, Maria Wilhelmina NASHWA I ET AL: "Effect of Ferula assafoetida 4852 Hombourg (BE) on experimental murine Schistosoma mansoni • VAESSEN, Jan Jozef infection.", XP002592455, Database accession 4852 Hombourg (BE) no.
    [Show full text]
  • February 15, 2012 Chapter 34 Notes: Flatworms, Roundworms and Rotifers
    February 15, 2012 Chapter 34 Notes: Flatworms, Roundworms and Rotifers Section 1 Platyhelminthes Section 2 Nematoda and Rotifera 34-1 Objectives Summarize the distinguishing characteristics of flatworms. Describe the anatomy of a planarian. Compare free-living and parasitic flatworms. Diagram the life cycle of a fluke. Describe the life cycle of a tapeworm. Structure and Function of Flatworms · The phylum Platyhelminthes includes organisms called flatworms. · They are more complex than sponges but are the simplest animals with bilateral symmetry. · Their bodies develop from three germ layers: · ectoderm · mesoderm · endoderm · They are acoelomates with dorsoventrally flattened bodies. · They exhibit cephalization. · The classification of Platyhelminthes has undergone many recent changes. Characteristics of Flatworms February 15, 2012 Class Turbellaria · The majority of species in the class Turbellaria live in the ocean. · The most familiar turbellarians are the freshwater planarians of the genus Dugesia. · Planarians have a spade-shaped anterior end and a tapered posterior end. Class Turbellaria Continued Digestion and Excretion in Planarians · Planarians feed on decaying plant or animal matter and smaller organisms. · Food is ingested through the pharynx. · Planarians eliminate excess water through a network of excretory tubules. · Each tubule is connected to several flame cells. · The water is transported through the tubules and excreted from pores on the body surface. Class Turbellaria Continued Neural Control in Planarians · The planarian nervous system is more complex than the nerve net of cnidarians. · The cerebral ganglia serve as a simple brain. · A planarian’s nervous system gives it the ability to learn. · Planarians sense light with eyespots. · Other sensory cells respond to touch, water currents, and chemicals in the environment.
    [Show full text]
  • Backyard Raccoon Latrines and Risk for Baylisascaris Procyonis
    LETTERS DOI: 10.3201/eid1509.090459 Backyard Raccoon Page County). Yards were selected on the basis of proximity to forest pre- References Latrines and Risk serves and willingness of homeowners for Baylisascaris to participate in the study. We located 1. Tsurumi M, Kawabata H, Sato F. Present status and epidemiological investigation procyonis latrines by systematically search- of Carios (Ornithodoros) capensis in ing yards, giving special attention to the colony of the black-footed albatross Transmission to horizontal substrates, such as piles of Diomedea nigripes on Tori-shima, Izu Humans wood and the bases of large trees (6). Islands, Japan [in Japanese]. Journal of We removed all fecal material to test the Yamashina Institute for Ornithology. To the Editor: Raccoons (Pro- 2002;10:250–6. for B. procyonis and stored it in plas- 2. Kawabata H, Ando S, Kishimoto T, Ku- cyon lotor) are abundant in urban en- tic bags at –20oC until analysis. Com- rane I, Takano A, Nogami S, et al. First vironments and carry a variety of dis- posite samples that were at least 2 g detection of Rickettsia in soft-bodied ticks eases that threaten domestic animals underwent fecal flotation in Sheather associated with seabirds, Japan. Microbiol (1) and humans (2,3). A ubiquitous Immunol. 2006;50:403–6. solution (7) (at least 1 g of every fe- 3. Sato Y, Konishi T, Hashimoto Y, Taka- parasite of raccoons, Baylisascaris cal deposit at a latrine) (n =131). We hashi H, Nakaya K, Fukunaga M, et al. procyonis causes a widely recognized identified B. procyonis eggs by mi- Rapid diagnosis of Lyme disease: flagellin emerging zoonosis, baylisascariasis croscopic examination on the basis of gene–based nested polymerase chain reac- (3).
    [Show full text]
  • Presumptive Treatment and Screening for Stronglyoidiasis, Infections
    Presumptive Treatment and Screening for Strongyloidiasis, Infections Caused by Other Soil- Transmitted Helminths, and Schistosomiasis Among Newly Arrived Refugees U.S. Department of Health and Human Services Centers for Disease Control and Prevention National Center for Emerging and Zoonotic Infectious Diseases Division of Global Migration and Quarantine November 26, 2018 Accessible link: https://www.cdc.gov/immigrantrefugeehealth/guidelines/domestic/intestinal-parasites- domestic.html Introduction Strongyloides parasites, other soil-transmitted helminths (STH), and Schistosoma species are some of the most common infections among refugees [1, 2]. Among refugees resettled in North America, the prevalence of potentially pathogenic parasites ranges from 8% to 86% [1, 2]. This broad range may be explained by differences in geographic origin, age, previous living and environmental conditions, diet, occupational history, and education level. Although frequently asymptomatic or subclinical, some infections may cause significant morbidity and mortality. Parasites that infect humans represent a complex and broad category of organisms. This section of the guidelines will provide detailed information regarding the most commonly encountered parasitic infections. A summary table of current recommendations is included in Table 1. In addition, information on overseas pre-departure intervention programs can be accessed on the CDC Immigrant, Refugee, and Migrant Health website. Strongyloides Below is a brief summary of salient points about Strongyloides infection in refugees, especially in context of the presumptive treatment with ivermectin. Detailed information about Strongyloides for healthcare providers can be found at the CDC Parasitic Diseases website. Background • Ivermectin is the drug of choice for strongyloidiasis. CDC presumptive overseas ivermectin treatment was initiated in 2005. Epidemiology • Prevalence in serosurveys of refugee populations ranges from 25% to 46%, with a particularly high prevalence in Southeast Asian refugees [2-4].
    [Show full text]
  • Prevalence, Intensity, Longevity, and Persistence of Anisakis Sp. Larvae and Lacistorhynchus Tenuis Metacestodes in San Francisco Striped Bass
    29 NOAA Technical Report NMFS 29 Prevalence, Intensity, Longevity, and Persistence of Anisakis sp. Larvae and Lacistorhynchus tenuis Metacestodes in San Francisco Striped Bass Mike Moser, Judy A. Sakanari, Carol A. Reilly, and Jeannette Whipple April 1985 U.S. DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration National Marine Fisheries Service NOAA TECHNICAL REPORTS NMFS The major responsibilities of the National Marine Fisheries Service (NMFS) are to monitor and assess the abundance and geographic distribution of fishery resources, to understand and predict fluctuations in the quantity and distribution of these resources, and to establish levels for optimum use ofthe resources. NMFS is also charged with the development and implemen­ tation of policies for managing national fishing grounds, development and enforcement of domestic fisheries regulations, surveillance of foreign fishing off United States coastal waters, and the development and enforcement of international fishery agreements and policies. NMFS also assists the fishing industry through marketing service and economic analysis programs, and mongage insurance and vessel construction subsidies. It collects, analyzes, and publishes statistics on various phases of the industry. The NOAA Technical Repon NMFS series was established in 1983 to replace two subcategories of the Technical Reports series: "Special Scientific Repon-Fisheries" and "Circular." The series contains the following types of repons: Scientific investigations that document long-term continuing programs of NMFS, intensive scientific reports on studies of restricted scope, papers on applied fishery problems, technical repons of general interest intended to aid conservation and management, repons that review in considerable detail and at a high technical level cenain broad areas of research, and technical papers originating in economics studies and from management investigations.
    [Show full text]
  • Diseases of ND Fish and Wildlife Brochure 2011.Indd
    NORTH DAKOTA GAME RIVERDALE OFFICE: AND FISH DEPARTMENT 406 Dakota Avenue HEADQUARTERS OFFICE: Riverdale, ND 58565 100 North Bismarck Expressway (701) 654-7475 Bismarck, ND 58501 (701) 328-6300 JAMESTOWN OFFICE: 3320 East Lakeside Road DEVILS LAKE OFFICE: Jamestown, ND 58402 7928 45th Street NE (701) 253-6480 Devils Lake, ND 58301 (701) 662-3617 WILLISTON OFFICE: 13932 West Front Street DICKINSON OFFICE: Williston, ND 58801 225 30th Avenue SW (701) 774-4320 Dickinson, ND 58601 (701) 227-7431 LONETREE WMA: Headquarters 1851 23rd Avenue NE Harvey, ND 58341 gf.nd.gov (701) 324-2211 Email: [email protected] (701) 328-6300 NNORTHORTH DDAKOTAAKOTA GAMEGAME AANDND FFISHISH DDEPARTMENTEPARTMENT The NDGFD receives Federal financial assistance from the US Fish and Wildlife Service. In accordance with Title VI of the Civil Rights Act of 1964, Section 504 of the Rehabilitation Act of 1973, Title II of the Americans with Disabilities Act of 1990, the Age Discrimination Act of 1975, and Title IX of the Education Amendments of 1972, the NDGFD joins the US Depart- ment of the Interior and its Bureaus in prohibiting discrimination on the basis of race, color, national origin, age, disability, sex (in education programs or activities) and also religion for the NDGFD. If you believe you have been discriminated against in any program, activity, or facility as described above, or you desire further information, please write to: ND Game and Fish Department, Attn: Chief Administrative Services, 100 N. Bismarck Expressway, Bismarck, ND 58501-5095 or to: U.S. Fish and Wildlife Service, Attn: Civil Rights Coordinator, 4401 N.
    [Show full text]
  • Parasitology Group Annual Review of Literature and Horizon Scanning Report 2018
    APHA Parasitology Group Annual Review of Literature and Horizon Scanning Report 2018 Published: November 2019 November 2019 © Crown copyright 2018 You may re-use this information (excluding logos) free of charge in any format or medium, under the terms of the Open Government Licence v.3. To view this licence visit www.nationalarchives.gov.uk/doc/open-government-licence/version/3/ or email [email protected] This publication is available at www.gov.uk/government/publications Any enquiries regarding this publication should be sent to us at [email protected] Year of publication: 2019 The Animal and Plant Health Agency (APHA) is an executive agency of the Department for Environment, Food & Rural Affairs, and also works on behalf of the Scottish Government and Welsh Government. November 2019 Contents Summary ............................................................................................................................. 1 Fasciola hepatica ............................................................................................................. 1 Rumen fluke (Calicophoron daubneyi) ............................................................................. 2 Parasitic gastro-enteritis (PGE) ........................................................................................ 2 Anthelmintic resistance .................................................................................................... 4 Cestodes .........................................................................................................................
    [Show full text]
  • Baylisascaris Procyonis Roundworm Seroprevalence Among Wildlife Rehabilitators, United States and Canada, 2012–2015
    DISPATCHES Baylisascaris procyonis Roundworm Seroprevalence among Wildlife Rehabilitators, United States and Canada, 2012–2015 Sarah G.H. Sapp, Lisa N. Rascoe, Wildlife rehabilitators may represent a population at Patricia P. Wilkins, Sukwan Handali, risk for subclinical baylisascariasis due to frequent con- Elizabeth B. Gray, Mark Eberhard, tact with raccoons and their feces, which may contain Dana M. Woodhall, Susan P. Montgomery, infectious larvated B. procyonis eggs. We assessed the Karen L. Bailey, Emily W. Lankau,1 occurrence of antibodies to B. procyonis in a sample of Michael J. Yabsley wildlife rehabilitators from the United States and Canada and administered a questionnaire on rehabilitation experi- Baylisascaris procyonis roundworms can cause potentially ence and procedures. fatal neural larva migrans in many species, including hu- mans. However, the clinical spectrum of baylisascariasis is not completely understood. We tested 347 asymptomatic The Study adult wildlife rehabilitators for B. procyonis antibodies; 24 During 2012–2015, we collected serum samples from and were positive, suggesting that subclinical baylisascariasis is administered questionnaires to wildlife rehabilitators (de- occurring among this population. tails in online Technical Appendix, http://wwwnc.cdc.gov/ EID/article/22/12/16-0467-Techapp1.pdf). We tested serum samples for B. procyonis IgG using a recombinant B. procy- aylisascaris procyonis, a roundworm of raccoons onis repeat antigen 1 protein Western blot as described (7). B(Procyon lotor) and rarely dogs, can cause fatal neural Of 347 enrolled persons (Table 1), 315 (91%) reported larva migrans or ocular larval migrans in numerous bird current involvement in rehabilitation activities. Participants and mammal species, including humans (1). At least 54 had an average of 10.5 (median 7.0) years of animal re- human cases have been reported; however, cases may not habilitation experience.
    [Show full text]