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Medicom International Conference Series in Neurology EAN Congress 2021 European Academy of Neurology 19–22 JUNE 2021 Virtual Meeting PEER-REVIEWED CONFERENCE CONFERENCE REPORT Dexamethasone Not Erenumab Superior to Typing Behaviour to Indicated for Chronic Topiramate for Migraine Remotely Monitor Clinical Subdural Haematoma Treatment MS Status The DECSA trial demonstrated that In the direct head-to-head HER-MES Real-world smartphone typing be- dexamethasone is not indicated study, in patients with episodic and haviour is a potential digital bio for the treatment of symptomatic chronic migraine, erenumab showed marker to monitor clinical MS chronic subdural haematoma; sur- significantly better tolerability and status. It effectively distinguished gery is the appropriate treatment. efficacy versus topiramate. between MS patients with different levels of disability. read more on PAGE 6 read more on PAGE 14 read more on PAGE 16 Editor Prof. Hans-Peter Hartung, Heinrich-Heine-University Düsseldorf, Germany MEDIC AL PUBLISHERS Contents Letter from the Editor 3 COVID-19 3 First evidence of brainstem involvement in COVID-19 3 Cognitive/behavioural alterations persistent after COVID-19 COLOPHON 3 Neural base of persistent hyposmia after COVID-19 4 Neurological symptoms and complications affect outcomes Editor Prof. Hans-Peter Hartung Department of Neurology, 5 Cerebrovascular Disease Heinrich-Heine-University Düsseldorf, Germany 5 ICH only slightly increases mortality in COVID-19 patients Advisory Board Prof. Marinos Dalakas 5 Stroke with covert brain infarction indicates high vascular risk Thomas Jefferson University, Philadelphia, USA 6 Expanding precision medicine to stroke care Dr Stefan Schwab 6 Dexamethasone not indicated for chronic subdural haematoma University Hospital Erlangen, Germany 7 Cognitive Impairment and Dementia Publishing Director Paul Willers 7 Severe outcomes of COVID-19 in patients with dementia Science Officer Dr Rachel Giles 8 Hypertension pathology visible in white matter lesion volume Editorial Manager Lisa Colson 8 Promising diagnostic accuracy of plasma GFAP Editorial Coordinators Dr Joery Goossens 8 Sex modulates effect of cognitive reserve on SCD Deirdre Boucherie 9 Hypersensitivity to uncertainty in subjective cognitive decline Medical Writer Dr Michiel Tent Production Manager Desiree Heijl 10 Epilepsy Graphic Design MOOZ grafisch ontwerp 10 Minimally invasive device to detect focal seizure activity Graphics Wim Kempink 10 Long-term effectiveness of ANT-DBS in epilepsy confirmed ISSN 2468-8762 21:11 11 Good safety and efficacy of cenobamate for focal seizures All rights reserved. 11 Prenatal valproate exposure increases risk of adverse No part of this publication may be reproduced, distributed, or transmitted neurodevelopmental outcome in any form or by any means, including photocopying, recording, or other electronic or mechanical methods, without the prior written permission of 12 ‘Mozart effect’ in epilepsy: why Mozart tops Haydn the publisher, except in the case of brief quotations embodied in critical reviews and certain other noncommercial uses permitted by copyright law. 13 Migraine and Headache Copyright ©2021 Medicom Medische Uitgeverij BV 13 Factors associated with decreased migraine attack risk 13 Eptinezumab shows acute benefits during migraine attack Disclaimer: Our independent peer-reviewed Medicom Conference Reports are made 14 Erenumab superior to topiramate for migraine treatment possible by sponsoring. The ideas and opinions expressed in this journal or other associated publications do not necessarily reflect those of Medicom 14 Pregnant migraine patients at higher risk of complications Medical Publishers. Although great care has been taken in compiling the content of this publication, Medicom is not responsible or liable in 15 Occipital nerve stimulation in drug-resistant cluster headache any way for the currency of the information, for any errors, omissions or 15 Rhythmicity in primary headache disorders inaccuracies in the original articles, or for any consequences arising from the content. Products mentioned in this report may not be covered by 16 Multiple Sclerosis and NMOSD marketing authorisation in some countries. Product information, applicable in your country, should be reviewed before prescribing. The mention of any 16 Typing behaviour to remotely monitor clinical MS status product, service, or therapy in this publication should not be construed as an endorsement of the products mentioned. It is the responsibility of the 16 Machine-learning method accurately classifies patients with MS treating physician or other health care provider, relying on independent 17 Positive results from ublituximab versus teriflunomide experience and knowledge of the patient, to determine drug dosages and the best treatment for the patient. Readers are advised to check 17 Alemtuzumab in treatment-naïve patients with aggressive MS the appropriate medical literature and the product information currently provided by the manufacturer of each drug to be administered to verify 18 No higher early MS relapse frequency after stopping ponesimod the dosage, method, and duration of administration, or contraindications. 18 Satralizumab efficacious in AQP4-IgG-positive patients with NMOSD Readers are also encouraged to contact the manufacturer with questions about the features or limitations of any products. Medicom assumes no 19 Good long-term safety and efficacy of inebilizumab in NMOSD responsibility for any injury or damage to persons or property arising out of or related to any use of the material contained in this publication or to any 20 Neuromuscular Disorders errors or omissions. 20 24-month pooled FIREFISH data of risdiplam in SMA 20 Inability to recognise disgust as first cognitive symptom of ALS 21 Pathogenic T-cell signature identified in myasthenia gravis 21 Parkinson’s Disease MEDIC AL PUBLISHERS 21 Effect of prasinezumab on motor features in early PD 22 Levodopa-carbidopa intestinal gel in patients with advanced PD Head Office Postal address 22 Safinamide improves non-motor symptoms in PD Medicom Medical Publishers Medicom Medical Publishers 23 New Frontier – Navigated Transcranial Ultrasound Faas Eliaslaan 5 PO Box 90 23 Exploring the possibilities 3742 AR Baarn 3740 AB Baarn The Netherlands The Netherlands Join us on LinkedIn Telephone +31 85 4012 560 MEDIC AL PUBLISHERS E-mail [email protected] Letter from the Editor Prof. Hans-Peter Hartung Dear colleagues, Biography Prof. Hartung is currently Professor of Neurology Like last year`s EAN meeting and almost any of the at Heinrich-Heine-University Düsseldorf, Honorary Professor at Brain and Mind Center, University of big international congresses, EAN 2021 was again held Sydney, Visiting Professor at Medical University as a virtual meeting. So, while the splendour of Vienna Vienna and Palacky University Olomouc. He was and the chats in the Kaffeehäuser (coffee houses) were chairman of the Department of Neurology, missed, the extensive program provided a very up-to- Heinrich-Heine-University Düsseldorf from date overview of our quickly moving field. 2001-2020, director of the Center for Neurology and Neuropsychiatry from 2012-2020 and director of the Department of Conservative Medicine from Much news was communicated regarding diagnostic, 2012-2019. therapeutic, and pathogenetic advances in subdisciplines Prof. Hartung’s clinical and translational research like multiple sclerosis, movement disorders, epilepsy, the interests are in the field of basic and clinical dementias, and neuromuscular disorders. Appropriately, neuroimmunology and in particular multiple one focus was on COVID-19, its nervous system sclerosis and immune neuropathies, development manifestations, vaccinations, and specific management of new immunological, neuroprotective and neural repair promoting strategies. He has (co-)authored issues. more than 950 articles in peer-reviewed journals There were lively discussions during live Q&A sessions and 100 book chapters. He has been involved as and in the chatrooms. member of the Steering Committee in numerous As always, the main meeting was preceded by a range international multicentre therapeutic phase 2 and of excellent teaching courses providing high level 3 trials in multiple sclerosis, Guillain-Barré postgraduate educational sessions. Syndrome and CIDP. He was President of ECTRIMS and has served/ serves amongst others on the executive boards of I hope you will find this report highlighting some the European Charcot Foundation, the European outstanding contributions useful. Neurological Society, and the International We all expect and long for a face-to-face meeting at EAN Multiple Sclerosis Cognition Society (IMSCOGS). 2022. He is/was also member of the Editorial Board of a number of international journals. Prof. Hartung is a Fellow of the AAN and EAN, and has been chair/ With best wishes, member of the management group of the EAN Hans-Peter Hartung, MD FRCP FAAN FANA FEAN scientific panels on general neurology and multiple sclerosis. He is Corresponding and Honorary Fellow of several international societies. Conflict of Interest Statement: Hans-Peter Hartung has received fees for consulting, speaking, and serving on steering committees from Bayer Healthcare, Biogen, GeNeuro, MedImmune, Merck, Novartis, Opexa, Receptos Celgene, Roche, Sanofi Genzyme, CSL Behring, Octapharma, Teva, TG Therapeutics, and Viela Bio, with approval by the Rector of Heinrich-Heine University. CONFERENCE REPORT - EAN 2021 COVID-19