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Capital Market Day 2018

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Capital Market Day 2018 PRESENTATION CAPITAL MARKET DAY 2018 RADISSON BLU, ZURICH AIRPORT 4 OCTOBER 2018 CAPITAL MARKET DAY 2018 CREATING THE FUTURE Etienne Jornod Executive Chairman MILESTONE 2020 WHAT IS NEXT? WE ARE ON THE WAY Worldwide pharmaceutical company Central purchasing organisation for pharmacists © Vifor Pharma 4 October 2018 3 WE ARE BUILDING A FAST GROWING COMPANY 3 DRIVERS WITH BLOCKBUSTER POTENTIAL Ferinject® Exploit the potential Veltassa® Drive to blockbuster Vifor Fresenius Medical Care Renal Pharma Launch products and enhance value © Vifor Pharma 4 October 2018 4 PIPELINE & LIFE CYCLE MANAGEMENT DE-RISKED INVESTMENTS PHASE 1 PHASE 2 PHASE 3 COMMERCIAL PHASE 4 AFFIRM-AHF Ferroportin HEART-FID2) inhibitor1) Paediatric AMBER OWN PRODUCTS OWN DIAMOND Anti-infectives 2019 Avacopan 20193) LICENSING LICENSING CCX140 - PRODUCTS IN Vadadustat4) CR845 1) Iron overload; leveraging iron metabolism expertise 2) Daiichi Sankyo clinical trial 3) Assumes CMA approval 4) U.S. Filing expected by the end of 2019 © Vifor Pharma 4 October 2018 5 WE KNOW HOW TO CREATE A NEW MARKET! © Vifor Pharma 4 October 2018 6 FERINJECT® 4 October 2018 GLOBAL I.V. IRON IN-MARKET SALES MAT Q2-19961) 1) Excluding the market share of Vifor Pharma products (0.6%). Source: IQVIATM MIDAS® Quarterly panel, GERS, Insight Health, DN, DLI, Q2-2018. Average 2017 exchange rates have been applied. © Vifor Pharma 4 October 2018 8 GLOBAL I.V. IRON IN-MARKET SALES MAT Q2-2018 Source: IQVIATM MIDAS® Quarterly panel, GERS, Insight Health, DN, DLI, Q2-2018. Average 2017 exchange rates have been applied. © Vifor Pharma 4 October 2018 9 VELTASSA® 4 October 2018 GLOBAL POTASSIUM BINDER IN-MARKET SALES MAT Q2-20151) 1) Excluding the market share of Sorbisterit (1.6%) Source: IQVIATM MIDAS® Quarterly panel, GERS, Insight Health, DLI, Q2-2018. Average 2017 exchange rates have been applied. © Vifor Pharma 4 October 2018 11 GLOBAL POTASSIUM BINDER IN-MARKET SALES MAT Q2-2018 Source: IQVIATM MIDAS® Quarterly panel, GERS, Insight Health, DLI, Q2-2018. Average 2017 exchange rates have been applied. © Vifor Pharma 4 October 2018 12 GLOBAL I.V. IRON IN-MARKET SALES MAT Q2 WORLDWIDE VIFOR 2018 PHARMA 1,698 MILLION CHF 1,219 MILLION CHF = 71.9% MAT Q2 WORLDWIDE 1996 96 MILLION CHF © Vifor Pharma 4 October 2018 13 GLOBAL POTASSIUM BINDER MARKET VIFOR PHARMA = 28% 63 MILLION CHF MAT Q2 WORLDWIDE 2018 225 MILLION CHF MAT Q2 WORLDWIDE 2015 175 MILLION CHF © Vifor Pharma 4 October 2018 14 VFMCRP 4 October 2018 15 THE JOINT COMPANY UNIQUENESS OF THE BUSINESS MODEL MEDICAL DIRECT ACCESS R&D CLINICAL REGULATORY PRODUCTION COMMERCIAL AFFAIRS TO THE PATIENT CR845 Vadadustat CCX140 Avacopan THIS IS WHAT DIFFERENTIATES VIFOR PHARMA FROM A TYPICAL PHARMA COMPANY. © Vifor Pharma 4 October 2018 16 INCREDIBLE PENETRATION IN FKC CLINICS1) AND OTHER CLIENTS 1) Fresenius Kidney Care (FKC): Fresenius Medical Care North America dialysis provider organization © Vifor Pharma 4 October 2018 17 FINANCIAL AND CAPITAL MARKET CONSIDERATION 4 October 2018 18 VIFOR PHARMA VS. TOP SPI PERFORMERS THE HIGHEST SHARE PRICE RETURN SINCE 1995 4'540% 3'444% 2'657% 2'537% 2'236% 2'107% 2'022% 1'995% 1'060% 1'017% Vifor Pharma AG Logitech Tecan Group AG Sika AG Kuehne + Nagel Schindler Holding Chocoladefabriken Sonova Holding LEM Holding SA Cie Financiere International SA International AG AG Lindt & Spruengli AG Richemont SA AG Source: Bloomberg Note: share price increase from 01.09.1995 to 31.08.2018; excludes market capitalization below CHF 100m as of 01.09.1995. © Vifor Pharma 4 October 2018 19 OBJECTIVE 2025 WE ARE CONFIDENT TO DELIVER ON “MILESTONE 2020” THE OBJECTIVE 2025 IS TO CONTINUE TO GROW AT ONE OF THE FASTEST RATES IN THE PHARMACEUTICAL INDUSTRY… «WE HAVE BEEN • NET SALES GROWING EVERY YEAR • EBITDA FOR 22 YEARS1)!» • NET PROFIT 1) Net profit before minorities, excluding non-cash one off effects and launch and ramp-up costs of Veltassa® in 2016 and 2017 © Vifor Pharma 4 October 2018 20 CAPITAL MARKET DAY 2018 STRATEGY 2025 Stefan Schulze President of the Executive Committee & COO STRATEGY 2025 EXPLOIT OUR COMPETITIVE ADVANTAGES EXISTING GROWTH DRIVERS Ferinject® – Exploit the potential Veltassa® – Drive to blockbuster VFMCRP – Launch products and enhance value © Vifor Pharma 4 October 2018 22 FERINJECT® / INJECTAFER® EXPLOIT THE POTENTIAL 2019 2025 > CHF 2 billion Japan launch China launch in-market sales H2 2019 2021 potential AFFIRM-AHF FAIR-HF2 HEART-FID U.S. label completion completion completion update Post-approval study Post-approval study U.S. Post-approval study Focus on cardiology, patient blood management, nephrology and gastroenterology EU guidelines1) U.S. guidelines1) update based on update based on AFFIRM AHF HEART-FID 1) Targeted guidelines: © Vifor Pharma 4 October 2018 23 IRON DEFICIENCY SIGNIFICANT PBM OPPORTUNITIES PATIENT BLOOD MANAGEMENT (PBM) – EU51) COMMENTS 96K • Patient focused approach to 109K blood management • Medical benefit: i.v. iron improves outcomes, including mortality 1’365K1 • Economic benefit: reduction in 1’160K length of hospitalisation and blood transfusion • In-market sales opportunity of > CHF 200m in EU5 With iron deficiency Other i.v. iron Ferinject® Not treated 1) France, Germany, Italy, Spain and UK © Vifor Pharma 4 October 2018 24 LIFE CYCLE MANAGEMENT SUPPORTING FUTURE GROWTH FERINJECT® IN-MARKET SALES A LEADING PRODUCT • Most extensive clinical evidence with 28 published RCTs1) and 7’034 patients treated in RCTs • More than 8 million patient-years experience2) • Unique non-dextran-based carboxymaltose shell • Only high-dose i.v. iron to demonstrate efficient iron 3) 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 utilization in the body Europe U.S. ROW 1) Randomized clinical trials 2) Vifor Pharma analysis as of August 2018 3) Beshara, S et al. Br J Haematol 2003; 120:853-9 © Vifor Pharma 4 October 2018 25 VELTASSA® DRIVE TO BLOCKBUSTER STATUS 2019 2025 European rollout Japan launch Blockbuster Zeria status AMBER Guideline1) DIAMOND Guideline1) completion updates based on completion updates based on Post-approval study AMBER results Post-approval study DIAMOND results Label updates based on DIAMOND results 1) Targeted guidelines: © Vifor Pharma 4 October 2018 26 HYPERKALEMIA MARKET OPPORTUNITY BUILD MARKET AWARENESS U.S. – 3.0 MILLION PATIENTS EU5 – 3.1 MILLION PATIENTS JAPAN – 1.3 MILLION PATIENTS Total population: 327 million Total population: 320 million Total population: 127 million 12 14 12 10.7 10.3 11.5 10 12 10 10 8 8 8 6 6 4.7 6 4.8 4 4 4 2.3 2.4 1.7 1.8 2 2 2 1.1 0.8 0.5 0.8 0.5 0.8 0.5 0.1 0.1 0 0 0 CKD 3-4 only CKD 3-4 with HF HF only CKD 3-4 only CKD 3-4 with HF HF only CKD 3-4 only CKD 3-4 with HF HF only Total prevalence With hyperkalemia Total prevalence With hyperkalemia Total prevalence With hyperkalemia Source: USRDS 2013 ADR, CDC Source: from House AJKD Vol 72 | Iss 2 | August 2018 . De Nicola et Source: Saito Y et al. PLoS ONE 12 (9): e0184402.. 2008 ESC Heart al Nephrol Dial Transplant (2016) 31: 335–336 Failure 2016; 3: 145–151 © Vifor Pharma 4 October 2018 27 LIFE CYCLE MANAGEMENT UNLOCK FULL POTENTIAL WITH CLINICAL DATA STUDY AMBER DIAMOND Strengthen evidence of RAASi enabling Beneficial effect on CLINICAL OBJECTIVES morbidity and mortality Beneficial effect on blood pressure U.S. label change & STRATEGIC OBJECTIVES Guideline updates guideline updates RESULTS EXPECTED H1 2019 2022 © Vifor Pharma 4 October 2018 28 PRESENCE IN NEPHROLOGY BECOME A GLOBAL LEADER IN A FAST-GROWING MARKET EXPECTED GLOBAL MARKET EVOLUTION FOR PHARMACEUTICALS IN NEPHROLOGY 2017 2025 2.7% ~$20bn >$40bn VFMCRP current market share Rest of the nephrology market Source: EvaluatePharma 2017-22 CAGR of 10.3%, 2022-25 CAGR assumed unchanged, Vifor Pharma analysis © Vifor Pharma 4 October 2018 29 VFMCRP BECOME AN INNOVATION LAUNCH ENGINE 2019 2025 RetacritTM Rayaldee® CR845 > CHF 1bn launch launch launch reported sales Avacopan Vadadustat CCX140 Additional launches in launch1) launch launch nephrology Avacopan / ANCA AV Vadadustat CR845 / Uremic Pruritus Phase III trial Phase III trials Phase III trial completion completion completion Avacopan / C3G CCX140 / FSGS Phase II trial Phase II trial completion completion 1) Assumes Conditional Marketing Authorization approval © Vifor Pharma 4 October 2018 30 NEPHROLOGY NUMEROUS OPPORTUNITIES REMAIN CURRENT INDICATIONS PIPELINE INDICATIONS POTENTIAL INDICATIONS Hypernatremia Vascular calcification FSGS Iron deficiency Polycystic kidney disease ANCA associated vasculitis Anaemia Kidney stones aHUS Secondary hyperparathyroidism Hyperphosphatemia β-Thalassemia renal disease Hyperkalemia Uremic pruritus Metabolic acidosis Acute kidney injury C3G Diabetic nephropathy Fabry © Vifor Pharma 4 October 2018 31 NEPHROLOGY LEADERSHIP ON THE WHOLE NEPHROLOGY CHAIN PRE CLINICAL CLINICAL PRE-COMMERCIAL PARTNERSHIP IN-LICENSING DEALS AND PARTNERSHIPS CCX140 Avacopan GENERATION DATA CR845 Vadadustat COMMERCIAL COMMERCIAL PRE DIALYSIS DIALYSIS TRANSPLANTATION © Vifor Pharma 4 October 2018 32 STRATEGY 2025 EXPLOIT OUR COMPETITIVE ADVANTAGES EXISTING GROWTH DRIVERS EXISTING INFRASTRUCTURE Ferinject® – Exploit the potential • Leverage U.S. commercial infrastructure Veltassa® – Drive to blockbuster • Become EU partner of choice for non-European growth companies VFMCRP – Launch products and enhance value INORGANIC GROWTH – ADJACENT INDICATIONS NEW TECHNOLOGIES AND BUSINESS AREAS Licensing/acquisition across geographies & TAs1): • Exploit data & pay-for-performance (anaemia and bone-mineral metabolism management, etc.)
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