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Rare Air Temple Lung Center: in SICKNESS & in HEALTH Tough Cases, Exceptional Options MEDICAL STUDENTS COMMIT to COMMUNICATION

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Rare Air Temple Lung Center: in SICKNESS & in HEALTH Tough Cases, Exceptional Options MEDICAL STUDENTS COMMIT to COMMUNICATION LEWIS KATZ SCHOOL OF MEDICINE AT TEMPLE UNIVERSITY | TEMPLE UNIVERSITY HEALTH SYSTEM SUMMER 2018 QUERY THEORY A TRIBUTE TO BEATRICE MINTZ, PHD Rare Air Temple Lung Center: IN SICKNESS & IN HEALTH Tough Cases, Exceptional Options MEDICAL STUDENTS COMMIT TO COMMUNICATION AGENDA Temple HealthMagazine EDITOR Giselle Zayon [email protected] DESIGN & ART DIRECTION B&G Design Studios WRITERS & CONTRIBUTORS Andrew Becker JoAnne DeSanto-Bonewicz Grace Cushing Heather Greaves Christopher Guadagnino Meredith Mann Kaitlyn Oberg Kalani Simpson Jeremy Walter BUSINESS MANAGER Younndia Rush ADMINISTRATION Alan N. Rosenberg Senior Vice President/ The Anatomy of Reputation Chief Administrative Officer n organization’s reputation is affected by many things. Three recent Christopher Guadagnino, PhD Temple Health examples: Interim Lead, Communications The United Network for Organ Sharing has announced that Temple CONTACT US performs more lung transplants than any other center in the United Office of Communications A U.S. News & World Report counts 3509 N. Broad Street States; Temple Health’s Fox Chase Philadelphia, PA 19140 Cancer Center and Lewis Katz School of Medicine among the nation’s best; and the 215-707-4839 American Heart Association has recognized Temple’s Walter Koch, PhD, with its highest national honors for basic research. TempleHealth.org 1-800-TEMPLEMED Accomplishments like these elevate Temple’s name. Lewis Katz School of Medicine But what about the Temple medical students who saved the life of a man at a home- at Temple University less shelter in Philadelphia earlier this year? Their altruistic (and, might I add, clinically Temple University Hospital Temple University Hospital impeccable) actions are no less important. Episcopal Campus To a greater extent than we might imagine, the thoughtful, sometimes heroic, and Temple University Hospital Northeastern Campus mostly unsung things that students and faculty do every day define the reputations of Fox Chase Cancer Center our nation’s medical schools and teaching hospitals. Fox Chase Cancer Center at Buckingham National awards and ratings are just part of the reputational equation. Fox Chase Cancer Center Like heartbeat and respiration, reputation moves in human time. It rises and falls Medical Group Jeanes Hospital with every gesture of the human heart and human brain. Temple Health Oaks Temple Health Center City Temple Health Elkins Park Temple Health Ft. Washington Temple ReadyCare Temple Physicians, Inc. Temple University Physicians Temple Transport Team Temple Health refers to the health, education, and research activities carried out by the affiliates of Temple University Health System, Inc. (TUHS), and the Lewis Katz School of Medicine at Temple University. TUHS neither provides Larry R. Kaiser, MD, FACS nor controls the provision of health care. All health care is provided by its member Senior Executive Vice President for Health Affairs, Temple University organizations or independent health care The Lewis Katz Dean at the School of Medicine providers affiliated with TUHS member organizations. Each TUHS member Professor of Surgery, Lewis Katz School of Medicine organization is owned and operated pursuant to its governing documents. HEALTH SCIENCE CAMPUS: JOSEPH V. LABOLITO; KAISER: COURTESY KAISER KAISER: COURTESY LABOLITO; V. JOSEPH CAMPUS: SCIENCE HEALTH President & CEO, Temple University Health System SUMMER 2018 | TEMPLE HEALTH MAGAZINE | 1 42 SUMMER 2018 CONTENTS FEATURES 12 Rare Air The Temple Lung Center: Tough Cases, Exceptional Options BY GISELLE ZAYON 18 Taming the Flame Inflammation: The Internal Inferno BY GISELLE ZAYON 24 Query Theory A Tribute to Beatrice Mintz, PhD BY GISELLE ZAYON 28 In Sickness and in Health Medical Students Commit to Communication BY KALANI SIMPSON DEPARTMENTS 32 Inside Story The Writing of Students & Staff 36 Quest Lori Rink: Gastrointestinal Stromal Tumors 38 Tools of the Trade New Lung Biopsy Technology 40 Timeline Jeanes Hospital at 90 42 Change Agent 4 Robert McNamara: Emergency Medicine 48 So Noted Quotes & Quips 49 Artful Ending The CCDC170 Gene Protein IN EVERY ISSUE 1 Agenda By Larry Kaiser, MD, FACS 4 Currents News Roundup 6 33 44 Impact ON THE COVER: The rare air of advanced expertise. That’s what thousands of patients with advanced lung disease seek at OPPOSITE: TOMMY LEONARDI; THIS PAGE, TOP: CLINT BLOWERS; BOTTOM LEFT: DAN BEJAR; BOTTOM RIGHT: SIMON PRADES RIGHT: BOTTOM BEJAR; DAN LEFT: BOTTOM BLOWERS; CLINT TOP: THIS PAGE, LEONARDI; TOMMY OPPOSITE: Alumni News & Philanthropy Notes Temple every year. Photo illustration by Ann Cutting. SUMMER 2018 | TEMPLE HEALTH MAGAZINE | 3 EDUCATION & ENGAGEMENT RESEARCH & CLINICAL CURRENTS APPOINTMENTS & ACCOLADES CURRENTS Alzheimer’s Update an extra-virgin olive oil pre- serve memory and protect the brain against Alzheimer’s? According to research done at Temple, it can. CIn a laboratory study led by Domenico Praticò, MD, the Scott Richards North Star Foundation Chair in Alzheimer’s Research at Temple, extra-virgin olive oil reduced the formation of amyloid-beta plaque and neurofibrillary tangles in the brain, classic markers of Alzheimer’s disease. The study, published online in the Annals of Clinical and Translational Neurology, received global media at- tention from Newsweek magazine, USA Today, Yahoo!, the Daily Mail, and the Philadelphia Inquirer. Two other Praticò Alzheimer’s studies attracted widespread attention, too. One was the first to demonstrate the ability of a substance called PD146176 to reverse well-established cognitive decline and neuropathology. “In this exciting new study, the authors provide support for a new experimental treatment approach that works by helping nerve cells digest toxic proteins that might otherwise cause cell death,” said John Krystal, Editor of Biological Psychiatry and Chair of the Department of Psychiatry at the Yale University School of Medicine. In another study, published online in Translational Psychiatry, Praticò was the first to elucidate several mechanisms involved in declining glucose levels in the brain, a classic trait of Alzheimer’s. This study was also the first to identify a brain protein called p38 as a potential drug target in the treatment of Alzheimer’s. 4 | TEMPLE HEALTH MAGAZINE | SUMMER 2018 Photograph by CLINT BLOWERS HIV Cure in Sight The gene-editing company Excision Biotherapeutics, spun out of the Lewis Katz School of Medicine at Temple University, has secured $10 million in venture capital funding to continue to seek a cure for HIV. The announce- ment was covered by various media outlets, including the Wall Street Journal and the Philadelphia Business Journal. Due to the virus’s abil- ity to hide away in latent reservoirs, a permanent cure for HIV infection has remained elusive. But in 2017, using a powerful gene- editing technology known as CRISPR/Cas9, scientists at Temple and the University of Pittsburgh became the first to excise HIV DNA from the genomes of living animals Forensic Files to eliminate further viral replication. hen a young, seemingly healthy also help prevent another loss in the family — The research, reported by person dies suddenly, we can enabling siblings of the deceased to be media outlets around the “Woften determine the cause tested and treated for any genetic anomalies world and funded in part through DNA testing,” says Glenn Gerhard, found,” says Joshua Cooper, MD, Professor of by NIH, marks a major step MD, Chair of Medical Genetics and Molecular Medicine in the Section of Cardiology. forward in the pursuit of Biochemistry at Temple. “Often, we’ll find a ge- Regional medical examiners call upon a permanent cure for HIV netic heart condition that was never diagnosed.” Temple’s Arthur Washburn, PhD, too. Trained in infection. “Our eventual goal To this end, Sam P. Gulino, MD, Chief Medical physical anthropology, the Associate Professor of is a clinical trial in human Examiner of the Philadelphia Medical Examiner’s Anatomy and Cell Biology has been consulting in patients,” says Kamel Khalili, Office, has partnered with Temple’s Cardiac forensics since 1991. He’s consulted on numer- PhD, Chair of the Department Genetics Program. ous cases involving the excavation and skeletal of Neuroscience, Director of “Genetic testing can provide answers. It can analysis of human remains. the Center for Neurovirology, and Director of the Compre- hensive Neuro-AIDS Center at Temple. Khalili led the work in Rankings on the Rise collaboration with Wenhui “Temple’s high rankings by U.S. News and World Report, Princeton Review, MONEY, Washington Hu, MD, PhD (now Associate Monthly, and other purveyors of higher education send a clear message: Temple University Professor in Temple’s Center and its graduates continue to rise,” says Larry R. Kaiser, MD, FACS, Temple Health’s CEO. for Metabolic Disease Re- Temple earned places on lists such as “Northeastern Regional Best Colleges,” “Great search), and Won-Bin Young, Schools,” “Most Active Student Government,” “Top ‘Green’ Colleges,” “Best Colleges for Your PhD, who was at the Univer- Money,” and dozens more. Kiplinger’s Personal Finance recognized Temple as one of the 100 sity of Pittsburgh at the time best values among public colleges and universities nationwide. of the research and is now In the 2018 U.S. News and World Report “Best Global Universities” edition, Temple earned on the Temple Neuroscience all-time highs in numerous disciplines, including clinical medicine and public health. CLINT BLOWERS CLINT faculty. SUMMER 2018 | TEMPLE HEALTH MAGAZINE
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