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LEWIS KATZ SCHOOL OF MEDICINE AT TEMPLE UNIVERSITY | TEMPLE UNIVERSITY HEALTH SYSTEM WINTER 2021 CONQUERING THE CLOT Tackling Thrombosis with Technology and Tenacity COVID-19 AT TEMPLE: STORIES UNMASKED SEPSIS: INSIGHTS, INNOVATIONS AGENDA Temple Health Magazine EDITOR Giselle Zayon [email protected] Health Magazine DESIGN & ART DIRECTION B&G Design Studios WRITERS & CONTRIBUTORS TKarenemple Brooks HealthMagazine Christopher Guadagnino Meredith Mann Jennifer Reardon Andrew Smith Jeremy Walter BUSINESS MANAGER Younndia Rush ADMINISTRATION Christopher Guadagnino, PhD Director, Communications Anne Carlin Practical Wisdom Director, Alumni Relations CONTACT US n the spring of 2020, when the City of Philadelphia needed a large indoor Office of Communications space to convert to a field hospital during the COVID-19 pandemic, any 3509 N. Broad Street Philadelphia, PA 19140 number of complexes in town could have sufficed — but Temple was the 215-707-4839 only organization to answer that call, lending the City its 340,000- square-foot Liacouras Center (page 18). TempleHealth.org IIn 2017, a Temple physician named Riyaz Bashir, MD, was frustrated. Not a 1-800-TEMPLEMED single catheter on the market could do what he needed a catheter to do, so he Lewis Katz School of Medicine Temple University Hospital designed one himself. Now the unique tool — designed to instantly restore blood Temple University Hospital flow through blood clots — is poised for worldwide use (pages 12 and 44). There’s Episcopal Campus Temple University Hospital been lots of practical Temple thinking about blood clots: the namesake of the Jeanes Campus Temple University Hospital university’s Thrombosis Research Center — Sol Sherry, MD (1916-1993) — Northeastern Campus basically invented the field of using enzymes to melt clots (pages 12 and 46). Fox Chase Cancer Center Fox Chase Cancer Center Another field, colorectal surgery (page 32), owes much about its development to at Buckingham another wise and sensible Temple doc: Harry Bacon, MD ’25 (1900-1981). Fox Chase Cancer Center Medical Group Examples abound. Temple Health Oaks Practical wisdom — a Temple trademark — has made its mark on many fields. Temple Health Center City Even the actual fields of Valley Forge National Park. When the 3,500-acre tract was Temple Health Elkins Park Temple Health Ft. Washington nearly sold for development in 1970, a Temple alumnus named Kenneth Gordon, Temple ReadyCare MD ’48 (1924-2005), mounted the campaign to save it (page 53). Temple Physicians, Inc. Temple Faculty Practice Plan Were these people seeking fortune and fame? No. They simply saw what needed Temple Transport Team to be done and did it. Temple Health refers to the health, education, and research activities carried out by the affiliates of Temple University Health System, Inc. (TUHS), and the Lewis Katz School of Medicine at Temple University. TUHS neither provides nor controls the provision of health care. All health care is provided by its member organizations or independent health care providers affiliated with TUHS member organizations. Each TUHS member organization is owned and operated pursuant to its governing documents. It is the policy of Temple Health that there shall be no exclusion from, or participation in, and no one denied the benefits of, the delivery of quality medical care on the basis of race, ethnicity, religion, sexual orientation, gender, gender identity/ expression, disability, age, ancestry, color, Giselle H. Zayon national origin, physical ability, level of JOSEPH V. LABOLILTO V. JOSEPH Editor education, or source of payment. WINTER 2021 | TEMPLE HEALTH MAGAZINE | 1 18 WINTER 2021 CONTENTS FEATURES 12 Conquering the Clot Tackling Thrombosis with Technology and Tenacity BY GISELLE ZAYON 18 Behind the Mask: COVID-19 at Temple Stories Behind the Story BY MICHAEL VITEZ AND GISELLE ZAYON 26 Slaying Sepsis Insights and Innovations to Tame a Formidable Threat BY KAREN BROOKS 32 They Called Him “The Boss”: Harry Bacon, MD BY HOWARD ROSS, MD, FASCRS DEPARTMENTS 36 Inside Story The Writing of Students & Staff 40 Quest Mary Barbe, PhD: Repetitive Strain Injury 42 Change Agent Oneida Arosarena, MD, FACS: 26 Faculty Diversity and Inclusion 44 Tools of the Trade IN EVERY ISSUE The BASHIR™ Endovascular Catheter 1 Agenda 46 Timeline Editor’s Note Titan of Medicine: Sol Sherry, MD, MACP 4 Currents 52 So Noted News Roundup Quotes & Quips 48 Impact 53 Artful Ending Alumni Leaders & Philanthropy 12 OPPOSITE: ED CUNICELLI; TOP RIGHT: YUKO SHIMIZU; BOTTOM RIGHT: DARIA KIRPACH DARIA RIGHT: BOTTOM SHIMIZU; YUKO RIGHT: TOP ED CUNICELLI; OPPOSITE: ON THE COVER: Blood clots take a huge toll on public health. Photo illustration by MMJ Studio. WINTER 2021 | TEMPLE HEALTH MAGAZINE | 3 EDUCATION & ENGAGEMENT RESEARCH & CLINICAL CURRENTS APPOINTMENTS & ACCOLADES CURRENTS Teen Vaping ithin just months of its initial recognition in the summer of 2019, more than 2,700 cases (including 60 deaths) of E-cigarette or vaping product use-associatedW lung injury (EVALI) had already been reported to the Centers for Disease Control and Prevention. And nearly 80 percent of the patients were under the age of 35. “The surge in youth vaping is alarming,” says Jamie Garfield, MD, Associate Professor of Thoracic Medicine and Surgery at Temple. Between 2017 and 2019, the percentage of high school students who reported using E-cigarettes more than doubled (from 11.7 to 27.5 percent). And it more than tripled among middle school students (from 3.3 to 10.5 percent). At the request of the Pennsylvania Department of Health, Garfield, who is also a spokesperson for the American Lung Association, developed a vaping education outreach program for Philadelphia-area schools — and recruited Temple medical student volunteers to help. “Medical students are excellent ambassadors to deliver this message since they are closer in age to our audience,” Garfield says. “A lot can be lost when information is presented to teens by older authority figures.” 4 | TEMPLE HEALTH MAGAZINE | WINTER 2021 Photograph by CLINT BLOWERS Lay off the Brakes Researchers at the Lewis Katz School of Medicine and Fox Chase Cancer Center have shown, for the first time, that a molecule called EGR4 — known mainly for its role in male fertility — serves as a critical brake on immune system activa- tion. The study, published online in EMBO Reports, shows that taking EGR4 away — effectively releasing the brake — promotes the activation of killer T cells, which infiltrate and attack tumors, thereby boosting anticancer immunity. This strategy could open the door to a new mode of anticancer therapy. The research was led by Jonathan Soboloff, PhD, Professor of Medical Genetics and Molecular Biochemistry at Temple, and Dietmar J. Kappes, PhD, Professor of Blood Cell Development and Cancer at Fox Chase Cancer Center, and was supported by the National Institutes of Health. $12 Million for Heart Research TEMPLE HEALTH MADE our Temple research programs avenues,” says principal investigator Walter J. focused on molecular mechanisms Koch, PhD, FAHA, the W.W. Smith Endowed of heart injury and repair are now Chair in Cardiovascular Medicine and Director FORBES’ supported by a $12 million Program of the Center for Translational Medicine. BEST Project Grant (PPG) from the This is the Center for Translational Medicine’s FNational Heart, Lung, and Blood Institute. second PPG — prestigious federal grants awarded EMPLOYERS One relates to the role of G protein-coupled to pre-eminent research groups with track re- IN receptor kinases in heart function and disease; cords of significant scientific impact. Two honors PENNSYLVANIA another on the influence of gender on bone given for similar reasons were likewise recently marrow stem cells in heart-tissue repair; the bestowed on Koch himself: the 2020 Research LIST FOR THE third on cardiorenal syndrome; and the fourth Achievement Award of the International Society SECOND YEAR on mitochondrial calcium exchange to reduce for Heart Research and the 2020 Distinguished IN A ROW tissue injury associated with heart attack. Achievement Award of the American Heart RAUL ARIAS RAUL “All four aim to identify new therapeutic Association Basic Sciences Council. WINTER 2021 | TEMPLE HEALTH MAGAZINE | 5 CURRENTS Neuron Chink in the Armor Regeneration New research at Temple iofilms are dense communities alongside lower-dose antibiotics or antimicrobials shows that when present of harmful bacteria that grow on to safely eradicate biofilms before bacteria enter above its usual level, a tissues and implanted medical the circulation where they could lead to deadly molecule in the body called devices. sepsis infection.” Lin28 stimulated long-dis- According to Çagla Tükel, As reported in Nature Communications, tance axon regeneration BPhD, Associate Professor of Microbiology and 3H3 is a first-of-its-kind therapeutic molecule in laboratory models of Immunology at Temple, “Biofilms are notori- that was isolated by Scott Dessain, MD, of the spinal cord and optic ously difficult to eradicate, because they secrete Lankenau Institute for Medical Research, nerve injury. a tough protein called curli, which protects which supported the study, along with the NIH. Shuxin Li, MD, PhD, Pro- them like a shield.” In other biofilms research, Roberto fessor of Anatomy and Cell But Tükel’s team has made a breakthrough Caricchio, MD, Chief of Rheumatology, along Biology, based in the Shriners — literally — with an antibody called 3H3. with Tükel and Stefania Gallucci, MD, of the Hospitals