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Rabbit Anti-RGS12 antibody

SL19853R

Product Name: RGS12 Chinese Name: G signal转导调节因子12抗体 Alias: DKFZp761K1617; Regulator of G protein signalling 12. Organism Species: Rabbit Clonality: Polyclonal React Species: Human,Mouse,Rat, ELISA=1:500-1000IHC-P=1:400-800IHC-F=1:400-800ICC=1:100-500IF=1:100- 500（Paraffin sections need antigen repair） Applications: not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. Molecular weight: 156kDa Cellular localization: The nucleus Form: Lyophilized or Liquid Concentration: 1mg/ml immunogen: KLH conjugated synthetic peptide derived from human RGS12:601-700/1447 Lsotype: IgG Purification: affinitywww.sunlongbiotech.com purified by Protein A Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year Storage: when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed: PubMed This encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)- activating protein as well as a transcriptional repressor. This protein may play a role in Product Detail: tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008] Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Isoform 5: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis.

Subunit: Interacts with GNAI1, GNAI2 and GNAI3; the interactions are GDP-dependent.

Subcellular Location: Nuclear

Tissue Specificity: Isoform 3 is brain specific.

Similarity: Contains 1 GoLoco domain. Contains 1 PDZ (DHR) domain. Contains 1 PID domain. Contains 2 RBD (Ras-binding) domains. Contains 1 RGS domain.

SWISS: O14924

Gene ID: 6002

Database links:

Entrez Gene: 6002 Human Entrezwww.sunlongbiotech.com Gene: 71729 Mouse Gene: 54292 Rat

Omim: 602512 Human

SwissProt: O14924 Human

SwissProt: Q8CGE9 Mouse

SwissProt: O08774 Rat

Unigene: 196208 Mouse Unigene: 9796 Rat

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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