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Overlap Between Systemic Lupus Erythematosus and Rheumatoid Arthritis: Is It Real Or Just an Illusion?

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Overlap Between Systemic Lupus Erythematosus and Rheumatoid Arthritis: Is It Real Or Just an Illusion? Editorial Overlap Between Systemic Lupus Erythematosus and Rheumatoid Arthritis: Is It Real or Just an Illusion? The association between rheumatoid arthritis (RA) and sys- diseases, in which case the pathogenic mechanisms under- temic lupus erythematosus (SLE) has been debated for many lying each of them should be revised. years. Based on their different genetic background and path- Regarding classification criteria for rheumatic diseases, ogenic mechanisms, it has been argued that both diseases are almost all have been performed on cross-sectional evalua- complex, mutually exclusive entities. However, recent tions, hence they seem to neither adequately evaluate clini- knowledge is challenging this notion, suggesting that both cal and serological features collected over time nor assess diseases can indeed overlap. the dynamic course of the corresponding disease. When the In this issue of The Journal, Icen and colleagues explore 1982 revised classification criteria for SLE were formulated, the frequency of SLE features and their influence on mortal- the objective was to reliably discriminate SLE patients from ity in an incident cohort of 603 subjects with RA followed a heterogeneous group of inflammatory arthritides (most of over time1. This study was conducted in the Rochester them RA)4. In spite of that, some of these criteria are also Epidemiology Project, a centralized medical record-linkage common manifestations in RA (i.e., arthritis, pleuritis, peri- system that encompasses all healthcare data from residents carditis, or proteinuria) or are related to therapy (i.e., rash, of Rochester and Olmsted County, Minnesota, USA, since photosensitivity, oral ulcers, proteinuria, leukopenia, and 1909. This kind of project provides an extraordinary oppor- antinuclear antibodies). Thus, a significant number of RA tunity to conduct comprehensive population-based studies patients potentially meet SLE classification criteria. over long periods. A cumulative incidence of ≥ 4 SLE fea- Similarly, the 1987 revised classification criteria for RA tures (including arthritis) was found in 15.5% of patients intended to improve the specificity of the former criteria, after 25 years of followup, this being associated with a 2- with a better discrimination between patients with well fold increase in the risk of death. established RA versus patients with other rheumatic dis- Is there an explanation for the high incidence of SLE fea- eases (20% of them with SLE)5. Since a number of non-RA tures found in this cohort of RA patients? Information about patients also met some RA classification criteria, a warning SLE and RA association is scarce and discrepant. Cohen and was included: “four conditions (systemic lupus erythemato- colleagues reported that 11 of 309 (3.6%) patients with SLE sus, psoriatic arthritis, mixed connective tissue disease, and fulfilled classification criteria for RA, suggesting that both Reiter’s syndrome) appear likely to have substantial num- diseases are more frequently associated than expected by bers of patients who might fulfill the requirements of the chance2. In contrast, in a retrospective study including about new criteria, and caution should be observed in these cir- 7000 new patients, Panush and colleagues identified only 6 cumstances”. patients with overlapping criteria for RA and SLE, with a Following this line of thought, it may be concluded that 10-fold lower concurrent prevalence rate (0.09%) than that sequential concurrence of RA manifestations that are also expected by chance (1.2%)3. included in the SLE classification criteria explains the high With these data, whether RA and SLE are directly or frequency of SLE features. However, it is clear that some inversely related entities remains unclear; nonetheless, the patients with a well classified autoimmune rheumatic dis- surprising finding of 15.5% of RA patients fulfilling classi- ease also may have features considered hallmarks of anoth- fication criteria for SLE opens 2 options for interpretation: er one; for instance, a patient with established RA who pres- (1) the existing gaps in the classification systems make them ents with proliferative glomerulonephritis, psychosis, anti- not specific enough for differentiating some cases of RA dsDNA or anti-Sm antibodies, or other hallmarks of SLE. from SLE, and/or (2) there is a real association between both Do these clinical manifestations and autoantibodies reveal See SLE features in RA and their effect on overall mortality, page 50 Personal non-commercial use only. The Journal of Rheumatology Copyright © 2009. All rights reserved. 4 The Journal of Rheumatology 2009; 36:1; doi:10.3899/jrheum.081067 Downloaded on September 30, 2021 from www.jrheum.org the presence of a second autoimmune disorder in the same sequence (arginine-alanine-alanine) in positions 72 to 74 of patient, or are they atypical features from a unique disease? the ß-chain is well established17. These alleles, collectively Frequently, physicians are baffled by associations of termed “shared epitope” (SE), preferentially bind peptides autoimmune diseases, especially when features considered containing the non-standard amino acid citrulline (deiminat- hallmarks of another disease occur; many clinicians are even ed arginine). Dose-effect of the SE over the production of reluctant to consider overlap of a second systemic autoim- anti-CCP antibodies in RA has been reported; in addition, mune disease. As shown by Icen and colleagues, only 9 the association of the SE and erosive disease is thought to be patients (1.5%) were clinically diagnosed as having SLE, in an indirect effect mediated by antibodies against different spite of 15.5% fulfilling SLE classification criteria1. Why citrullinated proteins18. As seen in RA, 67% of SLE patients are rheumatologists unwilling to diagnose SLE–RA over- with major erosions have alleles of the SE, in contrast with lap? Although joint involvement is one of the most common only 22% of those with nonerosive arthritis. Moreover, the SLE manifestations, only a minority of patients (~5%) presence of 2 copies of the SE increases the risk of erosive develop deforming arthropathy. Typically it is characterized arthritis in SLE 8 times13. Besides RA and SLE, the associ- by a nonerosive arthropathy with correctable ulnar deviation ation of SE with anti-CCP antibody production and erosive of metacarpophalangeal joints, Z deformity of the thumb, arthropathy has also been described in patients with psoriat- and swan-neck deformity of fingers, resembling the ic arthritis19. Hence, recent evidence supports the hypothe- Jaccoud’s arthropathy first described in rheumatic fever. sis that anti-CCP antibody response (and probably, the entire However, less than 1% of SLE patients develop erosive abnormal citrulline metabolism including the SE) plays a arthropathy indistinguishable from RA, an entity also direct pathogenic role in the development of a severe and known as rhupus6,7. erosive arthritis phenotype, regardless of the underlying dis- The first insights about the RA and SLE overlap come ease. Finally, apart from its extensive use as an inflammato- from 1960, when Toone and colleagues described the pres- ry marker, C-reactive protein (CRP) is a pentraxin critically ence of LE cells (until then, considered as exclusive for involved in the disposal of necrotic detritus and apoptotic SLE) in sera of 15 patients with RA, 8 of them with particles. While CRP levels correlate directly with disease systemic manifestations8. Several following studies showed activity in RA, a failure in its production has been found in positive rheumatoid factor in almost all rhupus patients2,3,6,7. SLE, despite evident tissue inflammation. This under- Also, anti-RA33 antibodies (previously considered specific powered acute-phase response results in diminished clear- for RA) have been associated with erosive arthritis in SLE9. ance of dying cells, and has been hypothesized as critical in However, both antibodies are detected in SLE patients with the pathogenesis of SLE. Nevertheless, we have found that either erosive or nonerosive arthropathy and even in non- rhupus patients display adequate CRP response, with serum deforming, nonerosive arthropathy10. concentrations significantly higher than those found in SLE Since almost all information available on rhupus has patients with nonerosive arthritis (14.5 vs 0.8 mg/l, respec- been circumstantial, doubts about its existence have been tively; p = 0.01), suggesting that CRP may be an active path- raised. If rhupus represents SLE and RA overlap, an SLE ogenic agent in addition to its known utility as a serological subset with intense joint expression, or a distinctive entity is marker for an erosive arthritis pattern among SLE patients16. a matter of debate. There is no discussion about rhupus Longterm studies on incident cohorts imply some inher- being part of the SLE spectrum; the questioning has been ent biases and deficiencies (i.e., laboratory assays may not whether these patients also have RA. Currently, there is evi- be available or may change throughout the study period; the dence supporting the existence of rhupus as a true overlap clinical course and severity of the disease may change over syndrome. There are at least 3 biological markers that, being time); however, these studies have the advantage of collect- hallmarks of RA, are also present in rhupus, but not in SLE. ing valuable data about the course of a disease over time. First, an elevated production of the highly specific Additionally, since
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