A National Public Health Agenda for Osteoarthritis: 2020 Update
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Knee Osteoarthritis
Patrick O’Keefe, MD Knee Osteoarthritis Overview What is knee osteoarthritis? Osteoarthritis, also known as Osteoarthritis is the most common type of knee arthritis. "wear and tear" arthritis, is a common problem for many A healthy knee easily bends and straightens because of a people after they reach middle smooth, slippery tissue called articular cartilage. This age. Osteoarthritis of the knee substance covers, protects, and cushions the ends of the is a leading cause of disability leg bones that form your knee. in the United States. It develops slowly and the pain it Between your bones, two c-shaped pieces of meniscal causes worsens over time. cartilage act as "shock absorbers" to cushion your knee Although there is no cure for joint. Osteoarthritis causes cartilage to wear away. osteoarthritis, there are many treatment options available. How it happens: Osteoarthritis occurs over time. When the Using these, people with cartilage wears away, it becomes frayed and rough. Moving osteoarthritis are able to the bones along this exposed surface is painful. manage pain, stay active, and live fulfilling lives. If the cartilage wears away completely, it can result in bone rubbing on bone. To make up for the lost cartilage, Questions the damaged bones may start to grow outward and form painful spurs. If you have any concerns or questions after your surgery, Symptoms: Pain and stiffness are the most common during business hours call symptoms of knee osteoarthritis. Symptoms tend to be 763-441-0298 or Candice at worse in the morning or after a period of inactivity. 763-302-2613. -
Juvenile Arthritis and Exercise Therapy: Susan Basile
Mini Review iMedPub Journals Journal of Childhood & Developmental Disorders 2017 http://www.imedpub.com ISSN 2472-1786 Vol. 3 No. 2: 7 DOI: 10.4172/2472-1786.100045 Juvenile Arthritis and Exercise Therapy: Susan Basile Current Research and Future Considerations Department of Kinesiology and Health, Georgia State University, IL, USA Abstract Corresponding author: Susan Basile Juvenile Idiopathic Arthritis (JIA) is a chronic condition affecting significant numbers of children and young adults. Symptoms such as pain and swelling can [email protected] lead to secondary conditions such as altered movement patterns and decreases in physical activity, range of motion, aerobic capacity, and strength. Exercise therapy has been an increasingly utilized component of treatment which addresses both Department of Kinesiology and Health, primary and secondary symptoms. The objective of this paper was too give an Georgia State University, USA. overview of the current research on different types of exercise therapies, their measurements, and outcomes, as well as to make recommendations for future Tel: 630-583-1128 considerations and research. After defining the objective, articles involving patients with JIA and exercise or physical activity-based interventions were identified through electronic databases and bibliographic hand search of the Citation:Basile S. Juvenile Arthritis and existing literature. In all, nineteen articles were identified for inclusion. Studies Exercise Therapy: Current Research and involved patients affected by multiple subtypes of arthritis, mostly of lower body Future Considerations. J Child Dev Disord. joints. Interventions ranged from light systems of movement like Pilates to an 2017, 3:2. intense individualized neuromuscular training program. None of the studies exhibited notable negative effects beyond an individual level, and most produced positive outcomes, although the significance varied. -
Variation in the Initial Treatment of Knee Monoarthritis in Juvenile Idiopathic Arthritis: a Survey of Pediatric Rheumatologists in the United States and Canada
Variation in the Initial Treatment of Knee Monoarthritis in Juvenile Idiopathic Arthritis: A Survey of Pediatric Rheumatologists in the United States and Canada TIMOTHY BEUKELMAN, JAMES P. GUEVARA, DANIEL A. ALBERT, DAVID D. SHERRY, and JON M. BURNHAM ABSTRACT. Objective. To characterize variations in initial treatment for knee monoarthritis in the oligoarthritis sub- type of juvenile idiopathic arthritis (OJIA) by pediatric rheumatologists and to identify patient, physi- cian, and practice-specific characteristics that are associated with treatment decisions. Methods. We mailed a 32-item questionnaire to pediatric rheumatologists in the United States and Canada (n = 201). This questionnaire contained clinical vignettes describing recent-onset chronic monoarthritis of the knee and assessed physicians’ treatment preferences, perceptions of the effective- ness and disadvantages of nonsteroidal antiinflammatory drugs (NSAID) and intraarticular corticos- teroid injections (IACI), proficiency with IACI, and demographic and office characteristics. Results. One hundred twenty-nine (64%) questionnaires were completed and returned. Eighty-three per- cent of respondents were board certified pediatric rheumatologists. Respondents’ treatment strategies for uncomplicated knee monoarthritis were broadly categorized: initial IACI at presentation (27%), initial NSAID with contingent IACI (63%), and initial NSAID with contingent methotrexate or sulfasalazine (without IACI) (10%). Significant independent predictors for initial IACI were believing that IACI is more effective than NSAID, having performed > 10 IACI in a single patient at one time, and initiating methotrexate via the subcutaneous route for OJIA. Predictors for not recommending initial or contin- gent IACI were believing that the infection risk of IACI is significant and lacking comfort with per- forming IACI. Conclusion. There is considerable variation in pediatric rheumatologists’ initial treatment strategies for knee monoarthritis in OJIA. -
Septic Arthritis of the Sternoclavicular Joint
J Am Board Fam Med: first published as 10.3122/jabfm.2012.06.110196 on 7 November 2012. Downloaded from BRIEF REPORT Septic Arthritis of the Sternoclavicular Joint Jason Womack, MD Septic arthritis is a medical emergency that requires immediate action to prevent significant morbidity and mortality. The sternoclavicular joint may have a more insidious onset than septic arthritis at other sites. A high index of suspicion and judicious use of laboratory and radiologic evaluation can help so- lidify this diagnosis. The sternoclavicular joint is likely to become infected in the immunocompromised patient or the patient who uses intravenous drugs, but sternoclavicular joint arthritis in the former is uncommon. This case series describes the course of 2 immunocompetent patients who were treated conservatively for septic arthritis of the sternoclavicular joint. (J Am Board Fam Med 2012;25: 908–912.) Keywords: Case Reports, Septic Arthritis, Sternoclavicular Joint Case 1 of admission, he continued to complain of left cla- A 50-year-old man presented to his primary care vicular pain, and the course of prednisone failed to physician with a 1-week history of nausea, vomit- provide any pain relief. The patient denied any ing, and diarrhea. His medical history was signifi- current fevers or chills. He was afebrile, and exam- cant for 1 episode of pseudo-gout. He had no ination revealed a swollen and tender left sterno- chronic medical illnesses. He was noted to have a clavicular (SC) joint. The prostate was normal in heart rate of 60 beats per minute and a blood size and texture and was not tender during palpa- pressure of 94/58 mm Hg. -
Adult Still's Disease
44 y/o male who reports severe knee pain with daily fevers and rash. High ESR, CRP add negative RF and ANA on labs. Edward Gillis, DO ? Adult Still’s Disease Frontal view of the hands shows severe radiocarpal and intercarpal joint space narrowing without significant bony productive changes. Joint space narrowing also present at the CMC, MCP and PIP joint spaces. Diffuse osteopenia is also evident. Spot views of the hands after Tc99m-MDP injection correlate with radiographs, showing significantly increased radiotracer uptake in the wrists, CMC, PIP, and to a lesser extent, the DIP joints bilaterally. Tc99m-MDP bone scan shows increased uptake in the right greater than left shoulders, as well as bilaterally symmetric increased radiotracer uptake in the elbows, hands, knees, ankles, and first MTP joints. Note the absence of radiotracer uptake in the hips. Patient had bilateral total hip arthroplasties. Not clearly evident are bilateral shoulder hemiarthroplasties. The increased periprosthetic uptake could signify prosthesis loosening. Adult Stills Disease Imaging Features • Radiographs – Distinctive pattern of diffuse radiocarpal, intercarpal, and carpometacarpal joint space narrowing without productive bony changes. Osseous ankylosis in the wrists common late in the disease. – Joint space narrowing is uniform – May see bony erosions. • Tc99m-MDP Bone Scan – Bilaterally symmetric increased uptake in the small and large joints of the axial and appendicular skeleton. Adult Still’s Disease General Features • Rare systemic inflammatory disease of unknown etiology • 75% have onset between 16 and 35 years • No gender, race, or ethnic predominance • Considered adult continuum of JIA • Triad of high spiking daily fevers with a skin rash and polyarthralgia • Prodromal sore throat is common • Negative RF and ANA Adult Still’s Disease General Features • Most commonly involved joint is the knee • Wrist involved in 74% of cases • In the hands, interphalangeal joints are more commonly affected than the MCP joints. -
Joint Pain Or Joint Disease
ARTHRITIS BY THE NUMBERS Book of Trusted Facts & Figures 2020 TABLE OF CONTENTS Introduction ............................................4 Medical/Cost Burden .................................... 26 What the Numbers Mean – SECTION 1: GENERAL ARTHRITIS FACTS ....5 Craig’s Story: Words of Wisdom What is Arthritis? ...............................5 About Living With Gout & OA ........................ 27 Prevalence ................................................... 5 • Age and Gender ................................................................ 5 SECTION 4: • Change Over Time ............................................................ 7 • Factors to Consider ............................................................ 7 AUTOIMMUNE ARTHRITIS ..................28 Pain and Other Health Burdens ..................... 8 A Related Group of Employment Impact and Medical Cost Burden ... 9 Rheumatoid Diseases .........................28 New Research Contributes to Osteoporosis .....................................9 Understanding Why Someone Develops Autoimmune Disease ..................... 28 Who’s Affected? ........................................... 10 • Genetic and Epigenetic Implications ................................ 29 Prevalence ................................................... 10 • Microbiome Implications ................................................... 29 Health Burdens ............................................. 11 • Stress Implications .............................................................. 29 Economic Burdens ........................................ -
Approach to Polyarthritis for the Primary Care Physician
24 Osteopathic Family Physician (2018) 24 - 31 Osteopathic Family Physician | Volume 10, No. 5 | September / October, 2018 REVIEW ARTICLE Approach to Polyarthritis for the Primary Care Physician Arielle Freilich, DO, PGY2 & Helaine Larsen, DO Good Samaritan Hospital Medical Center, West Islip, New York KEYWORDS: Complaints of joint pain are commonly seen in clinical practice. Primary care physicians are frequently the frst practitioners to work up these complaints. Polyarthritis can be seen in a multitude of diseases. It Polyarthritis can be a challenging diagnostic process. In this article, we review the approach to diagnosing polyarthritis Synovitis joint pain in the primary care setting. Starting with history and physical, we outline the defning characteristics of various causes of arthralgia. We discuss the use of certain laboratory studies including Joint Pain sedimentation rate, antinuclear antibody, and rheumatoid factor. Aspiration of synovial fuid is often required for diagnosis, and we discuss the interpretation of possible results. Primary care physicians can Rheumatic Disease initiate the evaluation of polyarthralgia, and this article outlines a diagnostic approach. Rheumatology INTRODUCTION PATIENT HISTORY Polyarticular joint pain is a common complaint seen Although laboratory studies can shed much light on a possible diagnosis, a in primary care practices. The diferential diagnosis detailed history and physical examination remain crucial in the evaluation is extensive, thus making the diagnostic process of polyarticular symptoms. The vast diferential for polyarticular pain can difcult. A comprehensive history and physical exam be greatly narrowed using a thorough history. can help point towards the more likely etiology of the complaint. The physician must frst ensure that there are no symptoms pointing towards a more serious Emergencies diagnosis, which may require urgent management or During the initial evaluation, the physician must frst exclude any life- referral. -
Arthritis and Joint Pain
Fact Sheet News from the IBD Help Center ARTHRITIS AND JOINT PAIN Arthritis, or inflammation (pain with swelling) of the joints, is the most common extraintestinal complication of IBD. It may affect as many as 30% of people with Crohn’s disease or ulcerative colitis. Although arthritis is typically associated with advancing age, in IBD it often strikes younger patients as well. In addition to joint pain, arthritis also causes swelling of the joints and a reduction in flexibility. It is important to point out that people with arthritis may experience arthralgia, but many people with arthralgia may not have arthritis. Types of Arthritis • Peripheral Arthritis. Peripheral arthritis usually affects the large joints of the arms and legs, including the elbows, wrists, knees, and ankles. The discomfort may be “migratory,” moving from one joint to another. If left untreated, the pain may last from a few days to several weeks. Peripheral arthritis tends to be more common among people who have ulcerative colitis or Crohn’s disease of the colon. The level of inflammation in the joints generally mirrors the extent of inflammation in the colon. Although no specific test can make an absolute diagnosis, various diagnostic methods—including analysis of joint fluid, blood tests, and X-rays—are used to rule out other causes of joint pain. Fortunately, IBD-related peripheral arthritis usually does not cause any lasting damage and treatment of the underlying IBD typically results in improvement in the joint discomfort. • Axial Arthritis. Also known as spondylitis or spondyloarthropathy, axial arthritis produces pain and stiffness in the lower spine and sacroiliac joints (at the bottom of the back). -
Study Guide Medical Terminology by Thea Liza Batan About the Author
Study Guide Medical Terminology By Thea Liza Batan About the Author Thea Liza Batan earned a Master of Science in Nursing Administration in 2007 from Xavier University in Cincinnati, Ohio. She has worked as a staff nurse, nurse instructor, and level department head. She currently works as a simulation coordinator and a free- lance writer specializing in nursing and healthcare. All terms mentioned in this text that are known to be trademarks or service marks have been appropriately capitalized. Use of a term in this text shouldn’t be regarded as affecting the validity of any trademark or service mark. Copyright © 2017 by Penn Foster, Inc. All rights reserved. No part of the material protected by this copyright may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without permission in writing from the copyright owner. Requests for permission to make copies of any part of the work should be mailed to Copyright Permissions, Penn Foster, 925 Oak Street, Scranton, Pennsylvania 18515. Printed in the United States of America CONTENTS INSTRUCTIONS 1 READING ASSIGNMENTS 3 LESSON 1: THE FUNDAMENTALS OF MEDICAL TERMINOLOGY 5 LESSON 2: DIAGNOSIS, INTERVENTION, AND HUMAN BODY TERMS 28 LESSON 3: MUSCULOSKELETAL, CIRCULATORY, AND RESPIRATORY SYSTEM TERMS 44 LESSON 4: DIGESTIVE, URINARY, AND REPRODUCTIVE SYSTEM TERMS 69 LESSON 5: INTEGUMENTARY, NERVOUS, AND ENDOCRINE S YSTEM TERMS 96 SELF-CHECK ANSWERS 134 © PENN FOSTER, INC. 2017 MEDICAL TERMINOLOGY PAGE III Contents INSTRUCTIONS INTRODUCTION Welcome to your course on medical terminology. You’re taking this course because you’re most likely interested in pursuing a health and science career, which entails proficiencyincommunicatingwithhealthcareprofessionalssuchasphysicians,nurses, or dentists. -
Effects of Extracellular Vesicles from Blood-Derived Products on Osteoarthritic Chondrocytes Within an Inflammation Model
International Journal of Molecular Sciences Article Effects of Extracellular Vesicles from Blood-Derived Products on Osteoarthritic Chondrocytes within an Inflammation Model Alexander Otahal 1,* , Karina Kramer 1, Olga Kuten-Pella 2 , Lukas B. Moser 1, Markus Neubauer 1, Zsombor Lacza 2,3, Stefan Nehrer 1 and Andrea De Luna 1 1 Center for Regenerative Medicine, Danube University Krems, 3500 Krems, Austria; [email protected] (K.K.); [email protected] (L.B.M.); [email protected] (M.N.); [email protected] (S.N.); [email protected] (A.D.L.) 2 OrthoSera GmbH, 3500 Krems, Austria; [email protected] (O.K.-P.); [email protected] (Z.L.) 3 Institute of Sport and Health Sciences, University of Physical Education, 1123 Budapest, Hungary * Correspondence: [email protected] Abstract: Osteoarthritis (OA) is hallmarked by a progressive degradation of articular cartilage. One major driver of OA is inflammation, in which cytokines such as IL-6, TNF-α and IL-1β are secreted by activated chondrocytes, as well as synovial cells—including macrophages. Intra-articular injection of blood products—such as citrate-anticoagulated plasma (CPRP), hyperacute serum (hypACT), and extracellular vesicles (EVs) isolated from blood products—is gaining increasing importance in regenerative medicine for the treatment of OA. A co-culture system of primary OA chondrocytes and activated M1 macrophages was developed to model an OA joint in order to observe the effects Citation: Otahal, A.; Kramer, K.; of EVs in modulating the inflammatory environment. Primary OA chondrocytes were obtained from Kuten-Pella, O.; Moser, L.B.; patients undergoing total knee replacement. -
Journal of Arthritis DOI: 10.4172/2167-7921.1000102 ISSN: 2167-7921
al of Arth rn ri u ti o s J García-Arias et al., J Arthritis 2012, 1:1 Journal of Arthritis DOI: 10.4172/2167-7921.1000102 ISSN: 2167-7921 Research Article Open Access Septic Arthritis and Tuberculosis Arthritis Miriam García-Arias, Silvia Pérez-Esteban and Santos Castañeda* Rheumatology Unit, La Princesa Universitary Hospital, Madrid, Spain Abstract Septic arthritis is an important medical emergency, with high morbidity and mortality. We review the changing epidemiology of infectious arthritis, which incidence seems to be increasing due to several factors. We discuss various different risk factors for development of septic arthritis and examine host factors, bacterial proteins and enzymes described to be essential for the pathogenesis of septic arthritis. Diagnosis of disease should be making by an experienced clinician and it is almost based on clinical symptoms, a detailed history, a careful examination and test results. Treatment of septic arthritis should include prompt removal of purulent synovial fluid and needle aspiration. There is little evidence on which to base the choice and duration of antibiotic therapy, but treatment should be based on the presence of risk factors and the likelihood of the organism involved, patient’s age and results of Gram’s stain. Furthermore, we revised joint and bone infections due to tuberculosis and atypical mycobacteria, with a special mention of tuberculosis associated with anti-TNFα and biologic agents. Keywords: Septic arthritis; Tuberculosis arthritis; Antibiotic therapy; Several factors have contributed to the increase in the incidence Anti-TNFα; Immunosuppression of septic arthritis in recent years, such as increased orthopedic- related infections, an aging population and an increase in the use of Joint and bone infections are uncommon, but are true rheumatologic immunosuppressive therapy [4]. -
Ankylosing Spondylitis
Henry Ford Hosp Med Journal Vol 27, No 1, 1979 Ankylosing Spondylitis Carlina V. jimenea, MD* Spondyllitisi , in the broad sense, means arthritis or inflam continuous bone." From these observations, Connor de mation of the spine. The term is derived from the Greek duced that the person "must have been immovable, that he words "spondylos," meaning vertebra, "-itis" for inflamma could neither bend nor stretch himself out, rise up, nor lie tion, and "ankylos," meaning bent or crooked. Ankylosing down norturn upon his side." Such a skeleton might appear spondylitis, therefore, is a chronic inflammatory disease of as illustrated (Figures 1 and 2).* the spine resulting in progressive stiffening with fusion ofthe various anatomical elements. Other early descriptions were reported by Wilks (1858), von Thaden (1863), Blezinger (1864), Bradhurst (1866), Virchow (1869), Harrison (1870), Flagg (1876) and Strum- History pell (1884).^ The most complete clinical description ofthe Ankylosing spondylitis has plagued man since antiquity. disease, however, is credited to von Bechterew, who in Ruffer and Reitti described the skeleton of a man living 1893 described what he thought was a new neurological during the third dynasty (2980 to 2900 B.C.) whose spinal disease characterized by stiffness ofall orpart of the spine, column, presumably in its entire length, was diseased and paresis of the muscles of the back, neck and extremities. transformed into a solid block because of new bone forma Later in 1897, Strumpell reported a group of cases with tion in the longitudinal ligaments. A skeleton found in progressive ankylosis ofthe spine and hip joints. In 1898, Nordpfalzdated (bytomb gifts enclosed)about400 B.C., was Marie described six cases characterized by an ascending reported by Arnold^ as showing similar changes.