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Generated by SRI International Pathway Tools Version 25.0, Authors S Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000009765Cyc: Streptomyces avermitilis MA-4680 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari an amino an amino an amino an amino an amino an amino an amino phosphate acid acid acid acid an amino an amino acid acid acid molybdate H + phosphate phosphate an amino an amino + spermidine α α sn-glycerol acid acid H -L- phosphate N-acetyl- -D-glucosamine ammonium ammonium putrescine D-gluconate 3-phosphate acid acid rhamnopyranose N,N'-diacetylchitobiose predicted predicted predicted predicted predicted predicted predicted predicted predicted ABC ABC ABC ABC ABC ABC ABC ABC ABC F0F1 ATP RS01065 RS27590 RS27105 FtsE RS25690 RS15815 RS14880 RS31535 RS31185 RS22825 RS14810 RS21405 RS20255 RS19445 RS06595 RS38395 RS38070 RS17995 RS36155 RS35865 YajC RS13495 RS17430 RS34865 RS05340 RS30815 RS17350 RS30720 RS30620 MycP RS30540 RS17195 RS30425 RS09640 RS34480 RS30245 RS30145 TatC RS17025 RS30065 RS30025 RS29890 RS34270 RS34265 RS01370 RS34205 RS34190 RS13090 RS29210 RS29140 RS01145 RS09170 RS29000 RS29060 RS34040 RS09180 RS29175 RS29425 RS16835 RS34195 RS13500 RS34055 RhaS RS20995 RS21000 RS33005 NgcE RS13800 RS28865 UgpC RS34500 RS30430 RS05155 RS24790 transporter transporter transporter transporter RS01425 RS36230 RS06090 transporter transporter transporter PntB RS36735 RS37665 RS18340 RS18555 RS11460 RS20065 MurJ RS21690 MurJ RS23120 RS15340 RS24375 RS25255 RS32425 RS26130 RS26665 RS16320 RS16450 transporter transporter synthase of an of an of an of an of an of an of an of molybdate of phosphate amino acid amino acid amino acid amino acid amino acid amino acid amino acid α-L- N-acetyl-α-D-glucosamine an amino an amino H + spermidine D-gluconate phosphate phosphate sn-glycerol H + rhamnopyranose phosphate N,N'-diacetylchitobiose ammonium ammonium an amino an amino acid acid putrescine 3-phosphate acid acid molybdate phosphate an amino an amino an amino an amino an amino an amino an amino acid acid acid acid acid acid acid chaplin Cofactor, Carrier, and Vitamin Biosynthesis Aromatic Compound Amine and Polyamine Degradation Biosynthesis Macromolecule Modification tRNA processing ditrans,octacis- UDP-N-acetyl- a nascent Nα,Nε-diacetyl-lysyl- UDP-N-acetyl- (4R)-4-hydroxy- a [DNA]-3'- a 5'-phospho- phosphoenol 5-deoxy-D- 5-methoxybenzimidazole NaMN a purine menadione NADH H + meso- 3-phenylpropanoate a [glutamine- a lipid II formaldehyde predicted cob(II)yrinate a,c- Fatty Acid and Lipid Biosynthesis ethanolamine utilization adenosylcobinamide undecaprenyldiphospho- α-D-muramoyl-L- peptidoglycan α-D-muramoyl- 2-oxoglutarate glucuronate cob(II)yrinate a,c-diamide [2Fe-2S] iron-sulfur superpathway of coenzyme A biosynthesis I (bacteria) thiamine diphosphate NAD de novo biosynthesis adenosylcobalamin thiamine diphosphate salvage II mycothiol biosynthesis adeninyl adenosylcobamide biosynthesis NAD de novo biosynthesis chorismate biosynthesis I a polycistronic putrescine degradation IV superpathway of putrescine degradation I 4-aminobutanoate urea degradation II ribonucleoside diaminopimelate D-alanyl-D-alanine ATP synthetase]- hydroxyl [DNA] dGDP pyruvate dGDP dADP ABC diamide biosynthesis I from adenosylcobinamide-GDP I (from aspartate) allantoin degradation N-acetyl-(N-acetyl-β-D- alanyl-D-glutamate (meso-DAP bifunctional 3- L-alanyl-γ-D- glutathione- 5-deoxy- urea urea biosynthesis II (late cluster biosynthesis biosynthesis I (E. coli) II (from tryptophan) salvage from cobalamin tRNA precursor 4-aminobutanoate degradation III 5'-triphosphate L-tyrosine vitamin B12- transporter RS04910 (early cobalt insertion) 3-methyl-2- a 5,10- palmitate biosynthesis (type II fatty acid synthase) D-erythrose ethanolamine to ureidoglycolate II glucosaminyl)muramoyl- containing) phenylpropionate/ glutamyl-meso-2,6- independent vitamin B12- glucuronate cobalt incorporation) 4-amino-2-methyl-5- D-glucopyranose octanoyl-[acyl-carrier CDP-diacylglycerol putrescine degradation nicotinate-nucleotide-- D-alanyl-D-alanine D-alanyl-D-alanine bifunctional non- dependent of urea uroporphyrinogen-III oxobutanoate methylenetetrahydrofolate 2-[(2R,5Z)- 4-phosphate (ammonia producing) putrescine urea D-aspartate L-alanyl-γ-D-glutamyl-L- NADH-quinone cinnamic acid diaminopimeloyl- formaldehyde dependent isomerase: uroporphyrinogen-III L-cysteine desulfurase 2-carboxy-4- trp cob(I)alamin pyrimidinemethanol 6-phosphate asp protein] biosynthesis biosynthesis I 3-deoxy-7- 4-aminobutanoate 4-aminobutanoate dimethylbenzimidazole bifunctional oxidoreductase: UDP-N- carboxypeptidase/ carboxypeptidase/ 4-hydroxy-2- homologous ribonucleotide iolB bifunctional adenine ethanolamine (S)-(+)-allantoin urease: lysyl-D-alanyl-D-alanine dioxygenase D-alanyl-D-alanine bifunctional [glutamine dehydrogenase: pyruvate ribonucleotide acetate acetate bifunctional methylthiazol-5(2H tryptophan 2,3- bifunctional inositol-3-phosphate L-aspartate oxidase: an acetoacetyl-[acp] (mitochondria, yeast) phosphoheptulonate 4-aminobutyrate- 4-aminobutyrate- phosphoribosyltransferase: adenosylcobinamide SAVERM_RS24960 acetylmuramoyl-L- lytic transglycosylase D-alanyl-D-alanine- D-alanyl-D-alanine- oxoglutarate end-joining reductase: uroporphyrinogen-III 3-methyl-2-oxobutanoate ammonia-lyase: allantoinase SAVERM_RS14155 ferredoxin subunit: synthetase] SAVERM_RS37135 kinase: pyk reductase: 5-deoxy- uroporphyrinogen-III cysteine desulfurase: )-ylidene]ethyl dioxygenase: hydroxymethylpyrimidine synthase: SAVERM_RS24200 DHAP synthase class II: -2-oxoglutarate -2-oxoglutarate cobT kinase/ SAVERM_RS24970 alanyl-D-glutamate-- domain-containing endopeptidase: dacB endopeptidase: dacB aldolase/2- DNA SAVERM_RS12835 RS36145 RS06130 C-methyltransferase/ hydroxymethyltransferase: HMP-PP nicotinate-nucleotide-- an acetoacetyl-[acp] a tRNA precursor SAVERM_RS23480 AllB: allB 4-aminobutanal ureA SAVERM_RS32545 adenylyltransferase/ glutathione- pyruvate SAVERM_RS12835 glucuronate a metal a metal C-methyltransferase/ SAVERM_RS32555 phosphate SAVERM_RS23380 cob(II)alamin kinase/ SAVERM_RS22210 2-iminosuccinate 3-oxoacyl-[acyl- glycerol-3-phosphate SAVERM_RS31350 ribonuclease D: transaminase: transaminase: adenosylcobinamide- D-aspartate ligase: SAVERM_RS24975 nuoE 2, 6-diaminopimelate protein: D-alanyl-D-alanine penicillin- dehydro-3-deoxy- ligase: ligD uroporphyrinogen- panB N-Formyl-L- dimethylbenzimidazole 3-oxoacyl-[acyl- 3-deoxy- with a 5' extension eutC urease: nicotinate-nucleotide-- penicillin- bifunctional 3- [glutamine synthetase]- independent kinase: pyk ribonucleoside- isomerase: cation cation uroporphyrinogen- [+ 2 isozymes] phosphomethylpyrimidine carrier-protein] dehydrogenase: SAVERM_RS11695 allantoate 4-aminobutanal gabT gabT phosphate SAVERM_RS25075 nuoF SAVERM_RS24990 ligase: SAVERM_RS30135 carboxypeptidase/ binding phosphogluconate [+ 3 isozymes] ribonucleoside- sulfite RS08495 sulfite III synthase: kynurenine phosphoribosyltransferase: carrier-protein] D-arabino- and a long 3' trailer a tRNA precursor with succinate gamma- succinate SAVERM_RS36495 dimethylbenzimidazole binding phenylpropionate/ adenylyl-L-tyrosine formaldehyde diphosphate iolB III synthase: thiamine phosphate cob(I)yrinic acid kinase: thiD Ins(3)P UDP-N-acetyl- quinolinate reductase: fabG SAVERM_RS13950 acetaldehyde guanylyltransferase: nuoH nuoI SAVERM_RS31505 [+ 5 isozymes] D-alanyl-D-alanine- protein aldolase: eda diphosphate 5-dehydro- SAVERM_RS24485 an S-sulfanyl-[L- α cobT reductase: fabG sn-glycerol heptulosonate a 5' extension and allantoate semialdehyde aminobutyraldehyde semialdehyde SAVERM_RS36500 phosphoribosyltransferase: protein cinnamic acid phosphorylase: dehydrogenase: reductase: SAVERM_RS24485 2-dehydropantoate synthase: a,c-diamide -D-glucosamine synthase 3-oxoacyl-[acyl- ribonuclease SAVERM_RS31080 SAVERM_RS25005 nuoK endopeptidase: dacB 2: mrdA reductase: 2-deoxy-D- cysteine desulfurase] HMP-P nicotinate-nucleotide-- 3-phosphate 7-phosphate a short 3' extension amidohydrolase: gamma- dehydrogenase: SAVERM_RS36505 cobT ditrans,octacis- 2: mrdA dioxygenase SAVERM_RS30780 SAVERM_RS05300 pyruvate SAVERM_RS15715 RS38495 uroporphyrinogen-III SAVERM_RS31415 adenosyltransferase: NadA: nadA carrier-protein] 3-oxoacyl-[acyl- PH: rph succinate- SAVERM_RS25020 nuoN UDP-N-acetyl- a mature a nascent penicillin- [DNA] dGTP SAVERM_RS15715 gluconate uroporphyrinogen-III D-inositol-3-phosphate dimethylbenzimidazole 3-dehydroquinate ribonuclease ethanol SAVERM_RS18060 aminobutyraldehyde SAVERM_RS04405 ammonium adenosyl- undecaprenyldiphospho-N- ferredoxin subunit: SAVERM_RS15720 C-methyltransferase: 2-dehydropantoate SAVERM_RS14935 reductase: fabG carrier-protein] ribonuclease D:polyribonucleotide semialdehyde α-D-muramoyl- peptidoglycan peptidoglycan binding glyoxylate pyruvate formate SAVERM_RS15720 sulfite RS33810 sulfite C-methyltransferase: asp 5-(2-hydroxyethyl) bifunctional glycosyltransferase: phosphoribosyltransferase: quinolinate synthase: ribonuclease D: P protein dehydrogenase: dehydrogenase: [+ 2 isozymes] allantoin degradation cobinamide acetyl-(N-acetylglucosaminyl)
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