Anti-CD5L (C-Terminal) Polyclonal Antibody (CPBT- 65327RC) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

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Anti-CD5L (C-terminal) polyclonal antibody (CPBT- 65327RC) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Product Overview This product detects an epitope within the C-terminal (CT) region of human CD5L, also known as Apoptosis Inhibitor expressed by Macrophages (AIM), and SP alpha. CD5L is a soluble 38kD glycoprotein which is specifically produced by mature macrophages, and has been shown to support their survival and enhance phagocytic function. CD5L expression is upregulated in response to LXR/RXR heterodimer activation. CD5L has been shown to mediate the survival of macrophages in atherosclerotic plaques. Western Blotting detects a band of approximately 38kDa in Raji cell lysates. Specificity CD5L Immunogen 13 amino acid peptide sequence near the carboxy terminus of human CD5L. Isotype IgG Source/Host Rabbit Species Reactivity Human, Mouse Conjugate Unconjugated Applications IHC-P; WB Format Purified IgG - liquid Size 100 μg Preservative 0.02% Sodium Azide Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Warnings For research purposes only GENE INFORMATION 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Gene Name CD5L CD5 molecule-like [ Homo sapiens (human) ] Official Symbol CD5L Synonyms CD5L; CD5 molecule-like; AIM; API6; PRO229; Spalpha; SP-ALPHA; CD5 antigen-like; CT-2; apoptosis inhibitor 6; igM-associated peptide; CD5 antigen-like (scavenger receptor cysteine rich family); CD5L; Entrez Gene ID 922 Protein Refseq NP_005885 UniProt ID O43866 Chromosome Location 1q21-q23 Function scavenger receptor activity; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.

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UNIVERSITY of CALIFORNIA, SAN DIEGO Towards an Understanding of Inflammation in Macrophages a Dissertation Submitted in Partial
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