BIOSCI 1999 MEDICALMICROBIOLOGY FallTerm2012Syllabus
Instructor Dr.JonBoyle LifeSciencesAnnex102 412Ͳ624Ͳ5842,[email protected] OfficeHours:Mondays10:00Ͳ11:00,Wednesdays10:00Ͳ11:00 WhileIpreferthatyouusethepostedofficehours,pleasecontactmetomakean appointmentifthosehoursdonotworkforyou. LectureTime/Place M/W/F9:00Ͳ9:50A.M.,A214LangleyHall
CourseObjectives Thiscoursewillfocusonmechanismsofmicrobialpathogenesisandthehost response,andthescientificapproachesthatareusedtoinvestigatethese processes.Howdomicrobesgainentryintothehost?Howtoconstituentsofthe normalmicrobialfloracausedisease?Howdomicrobialpathogensmodulate thehosttofacilitatetheirsurvival?Howdohostcellsrespondtomicrobial pathogens?How,inturn,domicrobesrespondtotheseinsults?Whatdoes genomicstellsusabouthowmicrobialpathogensevolve?Howdoemerging pathogenstakeadvantageofnewecologicalniches?Howcanmicrobial pathogensbethwarted? Thecoursewillberoughlydividedintothreesectionsbasedonthepathogenswe cover:Bacterialpathogens,viruses,andeukaryoticpathogens(parasites). Attheendofthiscoursestudentswillbeableto: Compareandcontrastdifferentmicrobialdiseases,includingthemechanismsof howtheycausedisease. Summarizetherole(bothpositiveandnegative)ofthehostininfectious disease,includingnaturalbarrierstoinfection,innateandacquiredimmune responsestoinfection,andinflammation. Understandthemodernapproachesthatareusedtostudymicrobesthrough readingsfromtheprimaryliterature. Compareandcontrasttherapeutictreatmentsformicrobialinfections,and distinguishwhenavaccine,antibiotic,orothertherapyislikelytobethemost appropriateresponse. Understandthegeneticsbehindhowmicrobesresisthostresponsesandhow antimicrobialresistanceevolves. Textbook Required:ThetextbookforthiscourseisMedicalMicrobiology,6thedition. EditedbyMurray,RosenthalandPfaller(2009). ReserveMaterials ThetextbookisonreserveinLangleyLibrary. CourseWeb IwillbeusingCourseWebtopostaportionofthecoursematerials.Thesyllabus, readingsoutsideofthetextbookassociatedwiththelectures,and announcementswillbeavailableathttp://courseweb.pitt.edu.Loginonthe mainpage.YouwillthenhaveaccesstoyourMyCourseWebpage,whichhas linkstoalloftheclassesforwhichyouhaveregisteredthatareusingCourseWeb. Ifyouneedhelp,contactthecomputerhelpdeskat412Ͳ624ͲHELP. EͲmail AlthougheͲmailwillnotbeusedroutinelyinthisclassforcommunication, occasionallyI maysendoutaneͲmailnoticeusingtheaddressesavailable BIOSCI 1999 SYLLABUS, FALL 2012, PAGE 1 throughCourseWeb (yourpitt.eduaddress).Suchnoticesarealsopostedas AnnouncementsonCourseWeb. IMPORTANT:IFYOUWRITEMEADIRECTEMAILORPOSTAMESSAGETOMEVIA COURSEWEB,IMAYTAKEUPTO48HOURSTOGETBACKTOYOU,SOTAKETHAT INTOCONSIDERATION.EQUALLYIMPORTANT:PLEASEMAKESURETOPUT YOURNAMEINTHEEMAILASWELLASTHECOURSENUMBERINTHESUBJECT LINE. Emailcommunication EachstudentisissuedaUniversityemailaddress([email protected])upon policy admittance.ThisemailaddressmaybeusedbytheUniversityforofficial communicationwithstudents.Studentsareexpectedtoreademailsenttothis accountonaregularbasis.FailuretoreadandreacttoUniversity communicationsinatimelymannerdoesnotabsolvethestudentfromknowing andcomplyingwiththecontentofthecommunications.TheUniversityprovide