BIOSCI 1999 MEDICAL MICROBIOLOGY Fall Term 2012
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BIOSCI 1999 MEDICALMICROBIOLOGY FallTerm2012Syllabus Instructor Dr.JonBoyle LifeSciencesAnnex102 412Ͳ624Ͳ5842,[email protected] OfficeHours:Mondays10:00Ͳ11:00,Wednesdays10:00Ͳ11:00 WhileIpreferthatyouusethepostedofficehours,pleasecontactmetomakean appointmentifthosehoursdonotworkforyou. LectureTime/Place M/W/F9:00Ͳ9:50A.M.,A214LangleyHall CourseObjectives Thiscoursewillfocusonmechanismsofmicrobialpathogenesisandthehost response,andthescientificapproachesthatareusedtoinvestigatethese processes.Howdomicrobesgainentryintothehost?Howtoconstituentsofthe normalmicrobialfloracausedisease?Howdomicrobialpathogensmodulate thehosttofacilitatetheirsurvival?Howdohostcellsrespondtomicrobial pathogens?How,inturn,domicrobesrespondtotheseinsults?Whatdoes genomicstellsusabouthowmicrobialpathogensevolve?Howdoemerging pathogenstakeadvantageofnewecologicalniches?Howcanmicrobial pathogensbethwarted? Thecoursewillberoughlydividedintothreesectionsbasedonthepathogenswe cover:Bacterialpathogens,viruses,andeukaryoticpathogens(parasites). Attheendofthiscoursestudentswillbeableto: Compareandcontrastdifferentmicrobialdiseases,includingthemechanismsof howtheycausedisease. Summarizetherole(bothpositiveandnegative)ofthehostininfectious disease,includingnaturalbarrierstoinfection,innateandacquiredimmune responsestoinfection,andinflammation. Understandthemodernapproachesthatareusedtostudymicrobesthrough readingsfromtheprimaryliterature. Compareandcontrasttherapeutictreatmentsformicrobialinfections,and distinguishwhenavaccine,antibiotic,orothertherapyislikelytobethemost appropriateresponse. Understandthegeneticsbehindhowmicrobesresisthostresponsesandhow antimicrobialresistanceevolves. Textbook Required:ThetextbookforthiscourseisMedicalMicrobiology,6thedition. EditedbyMurray,RosenthalandPfaller(2009). ReserveMaterials ThetextbookisonreserveinLangleyLibrary. CourseWeb IwillbeusingCourseWebtopostaportionofthecoursematerials.Thesyllabus, readingsoutsideofthetextbookassociatedwiththelectures,and announcementswillbeavailableathttp://courseweb.pitt.edu.Loginonthe mainpage.YouwillthenhaveaccesstoyourMyCourseWebpage,whichhas linkstoalloftheclassesforwhichyouhaveregisteredthatareusingCourseWeb. Ifyouneedhelp,contactthecomputerhelpdeskat412Ͳ624ͲHELP. EͲmail AlthougheͲmailwillnotbeusedroutinelyinthisclassforcommunication, occasionallyI maysendoutaneͲmailnoticeusingtheaddressesavailable BIOSCI 1999 SYLLABUS, FALL 2012, PAGE 1 throughCourseWeb (yourpitt.eduaddress).Suchnoticesarealsopostedas AnnouncementsonCourseWeb. IMPORTANT:IFYOUWRITEMEADIRECTEMAILORPOSTAMESSAGETOMEVIA COURSEWEB,IMAYTAKEUPTO48HOURSTOGETBACKTOYOU,SOTAKETHAT INTOCONSIDERATION.EQUALLYIMPORTANT:PLEASEMAKESURETOPUT YOURNAMEINTHEEMAILASWELLASTHECOURSENUMBERINTHESUBJECT LINE. Emailcommunication EachstudentisissuedaUniversityemailaddress([email protected])upon policy admittance.ThisemailaddressmaybeusedbytheUniversityforofficial communicationwithstudents.Studentsareexpectedtoreademailsenttothis accountonaregularbasis.FailuretoreadandreacttoUniversity communicationsinatimelymannerdoesnotabsolvethestudentfromknowing andcomplyingwiththecontentofthecommunications.TheUniversityprovides anemailforwardingservicethatallowsstudentstoreadtheiremailviaother serviceproviders(e,g.,Hotmail,AOL,Yahoo).Studentsthatchoosetoforward theiremailfromtheirpitt.eduaddress'toanotheraddressdosoattheirownrisk. Ifemailislostasaresultofforwarding,itdoesnotabsolvethestudentfrom respondingtoofficialcommunicationssenttotheirUniversityemailaddress.To forwardemailsenttoyourUniversityaccount,gotohttp://accounts.pitt.edu, clicklogintoyouraccountandclickonEditForwardingAddresses,andfollow theinstructionsonthepage.Besuretologoutofyouraccountwhenyouhave finished. LectureandExam Thelecturescheduleforthiscourseisattached.Pleasenotethedatesofthe Schedule exams(includingthefinal)toavoidanyfutureschedulingconflicts.MidͲterms willbegivenduringtheregularclassmeetings.Thefinalexamwillbeon Wednesday,December12,2012from12:00p.m.to1:50p.m.inLangleyA214. ThreemidͲtermexamsarescheduled,worth100pointseach.Note:thedatesof theexamsmaychange,inparticularifwegetbehindormisslectures.Thatwill beatmydiscretionbutIwillmakesuretogiveyouadequateleadtime. PleasebeawarethattherewillbenomakeͲupmidͲtermexams.Youwillbe allowedtodropyourlowestmidterm(NOTthefinal).Allstudentsarerequiredto takethefinalexaminordertopassthecourse,whichwillincludequestions coveringthelastsectionofthecourse(Parasites)aswellascomprehensive questions.Pleaseseetheinformationbelowonmissedexams. NewsandViews Basedonanoriginalresearcharticle,youwillberequiredtowriteaNewsand Assignment Viewsstylereportduringthesemester,topresentyourNewsandyour Viewstotheclassintheformofanoralpresentation,andbeadiscussantfor 2presentationsbyyourpeers. SigningupforApresentationdate:Theoralpresentationswillbeduring6class periodsthroughouttheterm(seeclassschedulefordetails).Youwillneedtosign upforoneofthesepresentationperiodsoncourseweb. SigningupforAresearchpaper:Youwillchooseanarticlefromalistprovidedin classandoncourseweb.Pleasesubmityourfirst,secondandthirdchoiceson courseweb. BeingAdiscussant:Eachstudentwillactasadiscussantfortwopapers presentedthroughoutthesemester,andwillberequiredto1)submitatleast3 questionstome2calendardaysbeforethepresentationand2)askatleastone ofthesequestionstothepresenteraftertheoralpresentation.Thesequestions shouldbeanalyticalinnature,andwillrequirethediscussanttohavereadthe paperindepth.Youwillsignuptobeadiscussantfor2papersoncourseweb. Theoralpresentation: Presentationswillbe10minutesinlength,with2minutes BIOSCI 1999 SYLLABUS, FALL 2012, PAGE 2 forquestions.BecauseoftimeconstraintsIwillwarnyouat9minutesandstop youat10minutestoallowtimeforthediscussantstoaskquestions.NOTE:you willlosepointsifyougoovertime.Sorehearse! TheNewsandViewsreport:TheNewsandViewsreportshouldbe3pages, doublespaced,andincludeabasicfiguresimilartoNewsandViewsarticles fromScienceandNature.Seecoursewebforsomeexamples.Yourwritten reportwillbedueonthesamedaythatyougiveyouroralpresentation. FinalGrade Yourfinalgradewillbedeterminedasfollows: Criterion TotalPossible ToptwomidͲtermexamscores 200points NewsandViewsPresentation 75points NewsandViewsDiscussion 15pointseachforatotalof30 NewsandViewsPaper 45points Cumulativefinalexam 150points Total 500points Yourfinalgradeisbasedonyourpercentoftotalpointsforthesemester(no curve),usingthefollowingscale: A+:ш100% A:93Ͳ99.9% AͲ:90Ͳ92.9% B+:88Ͳ89.9% B:83Ͳ87.9% BͲ:80Ͳ82.9% C+:78Ͳ79.9% C:73Ͳ77.9% CͲ:70Ͳ72.9% D+:68Ͳ69.9% D:63Ͳ67.9% DͲ:60Ͳ62.9% F:<59.9% MissedExams THEREARENOMAKEͲUPMIDͲTERMEXAMSOREXTRACREDIT OPPORTUNITIESINTHISCOURSE.IfyoumissmorethanonemidͲtermexam youshoulddiscusstheoptionsavailabletoyouwithyouradvisorortheSAS DeansOffice.Studentswhomissthefinalexamduetoanemergencyshould pursuetheGgradeoptionasdetailedbelow.Pleasenotethatyouare expectedtoshowuptoeachexamontime.Latearrivalswillbegiventhe examduringthetimethatremainsforthedesignatedexaminationperiod. Transportationproblemsandweatherissuesarenotconsideredanadequate excuse.Ifyouhavetotraveltoreachcampus,pleaseallowsufficienttimeto ensurethatyouarrivebythetimetheexambegins. ExamRegrades Youmayrequestaregradeofanyportionofanexambysubmittingyour requestinwritingandexplainingwhyyouthinkthegradingwasinerror.This requestmustbesubmittedtomewithinoneweekafterthedatethatthe gradedexamsarereturnedtotheclass.Unlesstheregraderequestissimply duetoanadditionerror,pleasebeawarethatyourentireexammaybe evaluatedandanyquestionthatwasgradedincorrectly(inyourfavor)may alsoberegradedresultinginpointsdeductedfromyourtotal. GGrades IfyouwishtopetitionforaGgrade,youmustsubmitarequestforthisgrade changeinwriting,andyoumustdocumentyourreason(s).Youwillbe requiredtomakearrangementsforthespecifictasksthatyoumustcomplete toremovetheGgrade.RememberthatGgrades,accordingtoSASguidelines, aretobegivenonlywhenstudentswhohavebeenattendingacourseand havebeenmakingregularprogressarepreventedbycircumstancesbeyond theircontrolfromcompletingthecourseafteritistoolatetowithdraw.Ifyou missthefinalexam,youmayreceiveaGgradeiftheaboveconditionsare BIOSCI 1999 SYLLABUS, FALL 2012, PAGE 3 met. AcademicIntegrity Cheating/plagiarismwillnotbetolerated.Studentssuspectedofviolatingthe Policy UniversityofPittsburghPolicyonAcademicIntegrity,notedbelow,willbe requiredtoparticipateintheoutlinedproceduralprocessasinitiatedbythe instructor.Aminimumsanctionofazeroscoreforthequiz,examorpaperwill beimposed. StudentsinthiscourseareexpectedtocomplywiththeUniversityof PittsburghSchoolofArtsandSciencesAcademicIntegrityCode (http://www.as.pitt.edu/fac/policies/academicͲintegrity).Anystudent suspectedoffailingtomeetthestudentobligationsofthecodeforanyreason duringthesemesterwillberequiredtoparticipateintheproceduresfor adjudication,initiatedattheinstructorlevel.Thismayinclude,butisnot limitedto,theconfiscationoftheexaminationorhomeworkpaperofany individualsuspectedofviolatingthecode. YoumaynotuseunauthorizedmateriAlsduringanexAm,includingnotes, dictionAries,calculators,pagers,telephones,PDAs,andanydevicethAtcan connecttotheinternet. YoumustsubmitforgradingonlymateriAlthatiswrittenexclusivelyinyour ownwordsandwrittenordrawninyourownhandwriting. ViolationoftheAcademicIntegrityCoderequirestheinstructortosubmitan AcademicIntegrityViolationReporttotheDean. Special Ifyouhaveadisabilityforwhichyouareormayberequestingan Accommodations accommodation,youareencouragedtocontactbothyourinstructorandthe OfficeofDisabilityResourcesandServices,216WilliamPittUnion,412648Ͳ 7890/4123837355(FTY),asearlyaspossibleintheterm.DisabilityResources andServiceswillverifyyourdisabilityanddeterminereasonable