ESCMID PGTW PARASITIC INFECTIONS OF THE ARABIAN PENINSULA AL AIN, UAE 17-19 MARCH 2016 Common Helminthic Infections in the Middle East Míriam J. Álvarez-Martínez M.D., Ph.D. Microbiology Department Hospital Clinic, Barcelona (Spain) ISGlobal (Barcelona© by Institute author for Global Health) Faculty of Medicine-University of Barcelona
[email protected] ESCMID Online Lecture Library © by author LAS FALLAS- VALENCIA, SPAIN ESCMID Online Lecture Library © by author ESCMID Online Lecture Library OUTLINE • Helminthic Infections – yesterday, today & always? Global Burden • Coinfections & Immunity • Strongyloides: Infection & Hyperinfection • Lymphatic Filariais© by author • Conclusions ESCMID Online Lecture Library 2008 © by author Three generalESCMID migration routes ofOnline humans in prehistory Lecture hypothesized fromLibrary Asia to the Americas. (a) Represents the longest-standing hypothesis of a migration route through Beringia and into North America at the time of low sea level and glacial maximum (b) Parasite probe data are consistent with a Coastal migration or (c) Trans-Pacific migration © by author ESCMID Online Lecture Library PHOTOGRAPH COURTESY DENNIS VAN GERVEN Metazoa PlatyhelmintosPlatyhelminths NematohelmintosNematodes gusanosFlatworms planos gusanosRoundworms redondos Soil CestodosCestodes TrematodosTrematodes Nematodos Filarial © by authorTransmitted Tapeworms Flukes worms tape worms flukes roundHelminths worms ESCMID Online Lecture Library GLOBAL BURDEN • It is estimated that approximately one-third of the 3 billion people that live on less than 2 US dollars per day in developing regions of sub-Saharan Africa, Asia, and the Americas are infected with one or more helminths. • Human helminthic infections have both direct and indirect effects on malaria and HIV/AIDS in developing countries, where are frequenty© by author coendemic. • Coinfections have additive effects, such as severe anemia,synergisticESCMID Online effects, such Lecture as increased Library transmission of the malaria, HIV, and/or increased susceptibility to infection.