Journal of Thoracic Disease Volume 6 Number 6 Jun 2014 Pages 571-863; E61-E147 Indexed in Pub Ed
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Journal Thoracic of Disease Vol 6, No 6 June 2014 ISSN 2072-1439 JJOURNALOURNAL ofof TTHORACICHORACIC DDISEASEISEASE www.jthoracdis.com Volume 6 Number 6 Jun 2014 Pages 571-863; 6 Number E61-E147 Volume 6 Jun 2014 Published by Pioneer Bioscience Publishing Company Indexed in PubMed, SCI Indexed in Pub ed Aims and Scope Address: 9A Gold Shine Tower, 346-348 Queen’s Road The Journal of Thoracic Disease (JTD, J Thorac Dis, pISSN: Central, Sheung Wan, Hong Kong. Tel: +852 3488 1279; 2072-1439; eISSN: 2077-6624) was founded in Dec 2009, Fax: +852 3488 1279. indexed in Pubmed/Pubmed Central in Dec 2011, and Science Email: [email protected] Citation Index (SCI) on Feb 4, 2013. It is published quarterly www.jthoracdis.com (Dec 2009- Dec 2011), bimonthly (Jan 2012- Dec 2013), and monthly (Jan 2014-), and openly distributed worldwide. JTD Note to NIH Grantees publishes manuscripts that describe new findings in the field Pursuant to NIH mandate, Pioneer Bioscience Publishing to provide current, practical information on the diagnosis Company will post the accepted version of contributions and treatment of conditions related to thoracic disease (lung authored by NIH grant-holders to PubMed Central upon disease, cardiac disease, breast disease and esophagus disease). acceptance. This accepted version will be made publicly Original articles are considered most important and will be available 2 months after publication. For further information, processed for rapid review by the members of Editorial Board. see www.thepbpc.org Clinical trial notes, Cancer genetics reports, Epidemiology notes and Technical notes are also published. Case reports Conflict of Interest Policy for Editors implying new findings that have significant clinical impact are The full policy and the Editors’ disclosure statements are carefully processed for possible publication. Review articles available online at: www.jthoracdis.com are published in principle at the Editor’s request. There is no fee involved throughout the publication process. The acceptance of Disclaimer the article is based on the merit of quality of the manuscripts. The Publisher and Editors cannot be held responsible for All the submission and reviewing are conducted electronically errors or any consequences arising from the use of information so that rapid review is assured. contained in this journal; the views and opinions expressed do not necessarily reflect those of the Publisher and Editors, The Official Publication of: neither does the publication of advertisements constitute any v Guangzhou Institute of Respiratory Disease (GIRD) endorsement by the Publisher and Editors of the products v China State Key Laboratory of Respiratory Disease advertised. v First Affiliated Hospital of Guangzhou Medical University v Society for Thoracic Disease (STD) Cover image: The bronchoscopy procedure. (See PE82 in this issue). Endorsed by: v International COPD Coalition (ICC) For submission instructions, subscription and all other information visit www.jthoracdis.com Editorial Correspondence Daoyuan Wang, MD © 2014 Pioneer Bioscience Publishing Company Managing Editor Pioneer Bioscience Publishing Company Editor-in-Chief Nanshan Zhong, MD Academician, Chinese Academy of Engineering. Guangzhou Institute of Respiratory Disease, Guangzhou, China Executive Editor-in-Chief Jianxing He, MD, FACS The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Executive Editor-in-Chief (Cardiovascular Surgery) Tristan D. Yan, BSc, MBBS, MS, MD, PhD Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia; The Collaborative Research (CORE) Group, Sydney, Australia Deputy Editors-in-Chief Duarte, USA London, United Kingdom Jin-Shing Chen, MD, PhD Kwun Fong, MBBS (Lon), FRACP, PhD Gaetano Rocco, MD, FRCS (Ed), FETCS, FCCP Taipei, Taiwan Brisbane, Australia Naples, Italy Rongchang Chen, MD, PhD Lawrence Grouse, MD, PhD Guangzhou , China Gig Harbor, USA Yi-Jen Chen, MD, PhD Shahzad G. Raja, MBBS, MRCSEd, FRCSEd (C-Th) Editorial Co-Directors & Executive Editors Statistical Editors Guangqiao Zeng, MD Jiqian Fang, PhD Guangzhou, China Guangzhou, China Daoyuan Wang, MD Baoliang Zhong, MD, PhD Guangzhou, China Hong Kong, China Associate Editors Section Editor (Systematic Review and Meta-analysis) Hatem A Azim Jr, MD Paul Zarogoulidis, MD, PhD Zhi-De Hu, M.M Jinan, China Brussels, Belgium Thessaloniki , Greece Wan-Jie Gu, MSc Guangzhou, China Kazuaki Takabe, MD, PhD, FACS Junya Zhu, MS, MA Zhi-Rui Zhou, MD Changchun, China Richmond, United States Boston, United States Gary Y. Yang, MD Section Editor (Cancer Registry, Prevention and Control) Loma Linda, United States Wanqing Chen, MD Beijing, China Editorial Board Wentao Fang, MD Hui-Wen Lo, PhD Robert Sturm, MSc, PhD James S Allan, MD Yoshinosuke Fukuchi, MD, PhD Kevin W. Lobdell, MD Xiaoning Sun, MD, PhD Rahul J Anand, MD Diego Gonzalez-Rivas, MD, FECTS Jiade J. Lu, MD, MBA Lijie Tan, MD, Vice Chief Emilio Bajetta, MD, SC Cesare Gridelli, MD Giovanni Mariscalco, MD, PhD Kosmas Tsakiridis, MD, PhD Peter J Barnes, DM, DSc, FRCP, Tomas Gudbjartsson, MD, PhD Doug McEvoy, MBBC, FRACP Kenneth WT Tsang, MD, FRCP FCCP, FMedSci, FRS Don Hayes, Jr, MD, MS, Med Mark J. McKeage, MD Mark I. van Berge Henegouwen, J. Patrick Barron, MD Andrea Imperatori, MD Walter McNicholas, MD, FRCPI, MD, PhD Bruno R. Bastos, MD Mary Sau Man Ip, MBBS(HK), FRCPC, FCCP Federico Venuta, MD Luca Bertolaccini, MD, PhD MD(HK), FRCP (London, Michael T. Milano, MD, PhD Ko Pen Wang, MD, FCCP Alessandro Brunelli, MD Edinburgh, Glasgow), FHKCP, John D. Mitchell, MD Qun Wang, MD Peter Calverley, MD FHKAM, FAPSR, FCCP Alyn H. Morice, MD Yi-Xiang Wang, MD Weiguo Cao, MD Rihard S. Irwin, MD, Master FCCP Akio Niimi, MD, PhD Zheng Wang, MD Mario Cazzola, MD Ki-Suck Jung, MD, PhD Antonio Passaro, MD Zhimin Wang, PhD Joe Y Chang, MD, PhD Markus Krane, MD Georgios Plataniotis, MD, PhD Bryan A Whitson, MD, PhD Wanqing Chen, MD Alexander Sasha Krupnick, MD David Price, M.B B.Chir, MA, Yunlong Xia, MD, PhD Yi-han Chen, MD, PhD Hyun Koo Kim, MD, PhD DRCOG, FRCGP Jin Xu, MS Leo L Cheng, PhD Anand Kumar, MD Gui-bin Qiao, MD, PhD Ping Yang, MD, PhD Xiangyang Chu, MD Aseem Kumar, PhD Klaus F Rabe, MD, PhD Stephen C. Yang, MD Kian Fan Chung, MD, DSc, FRCP Y. C. Gary Lee, MBChB, PhD, Dominik Rüttinger, MD, PhD, FACS Kazuhiro Yasufuku, MD, PhD Henri G. Colt, MD, FCCP FCCP, FRCP, FRACP Sundeep Salvi, MD, DNB, PhD, Anthony P.C. Yim, BM Thomas A. D’Amico, MD Mario Leoncini, MD FCCP BCh(Oxon), DM(Oxon), Giovanni Dapri, MD, FACS, FASMBS Jian Li, MD Martin Schweiger, MD FRCS(Eng) Keertan Dheda, MBBcH, Tianhong Li, MD, PhD Suresh Senan, MD Xiuyi Zhi, MD FCP(SA), FCCP, PhD(Lond), Wenhua Liang, MD Charles B. Simone, II, MD Ming Zhong, MD FRCP(Lond) Yang Ling, MD Yong Song, MD, PhD Caicun Zhou, MD, PhD Peter V. Dicpinigaitis, MD Deruo Liu, MD Ross Soo, MD Qinghua Zhou, MD Leonardo M. Fabbri Lunxu Liu, MD Joerg S. Steier, MD (D), PhD (UK) Zhi-hua Zhu, MD, PhD Journal Club Director Editorial Assistants Managing Editor Senior Editors Science Editors Executive Copyeditor Bing Gu, MD Maria Karina, MD, PhD, Katherine L. Ji Grace S. Li (Corresponding Melanie C. He Benti L. Peng FRCP Editor) Tina C. Pei Executive Typesetting Editor Parag Prakash Shah, PhD Eunice X. Xu Molly J. Wang Jian Li Elva S. Zheng Rui Wang Production Editor Nancy Q. Zhong Emily M. Shi Table of Contents Editorial 571 Tecemotide (L-BLP25) versus placebo after chemoradiotherapy for stage III non-small cell lung cancer (START): a randomized, double-blind, phase III trial Michael DeGregorio, Lin Soe, Michael Wolf 574 Unresectable stage III non-small cell lung cancer: is Tecemotide a new START for our patients? Els Wauters, Johan Vansteenkiste 578 Cetuximab in advanced non-small cell lung cancer (NSCLC): the showdown? Assunta Sgambato, Francesca Casaluce, Paolo Maione, Antonio Rossi, Fortunato Ciardiello, Cesare Gridelli 581 Fertility concerns and preservation strategies in young women with breast cancer Tadahiko Shien 584 Fertility issues in young breast cancer patients: what women want Matteo Lambertini, Ana Catarina Pinto, Lucia Del Mastro 589 Female breast cancer in Europe: statistics, diagnosis and treatment modalities Flora Zagouri, Theodoros N. Sergentanis, Alexandra Tsigginou, Constantine Dimitrakakis, George C. Zografos, Meletios-Athanassios Dimopoulos, Theodora Psaltopoulou 591 The burden of breast cancer from China to Italy Alessia Levaggi, Francesca Poggio, Matteo Lambertini Perspective 595 Tyrosine kinase inhibitors re-treatment beyond progression: choice and challenge Ru Zhang, Lingli Tu, Lan Sun Original Article 598 Nocturnal pulse rate and symptomatic response in patients with obstructive sleep apnoea treated with continuous positive airway pressure for one year Martino F. Pengo, Panagis Drakatos, Christopher Kosky, Adrian Williams, Nicholas Hart, Gian Paolo Rossi, Joerg Steier 606 Pulmonary hypertension in end-stage renal disease and post renal transplantation patients Esam H. Alhamad, Mohammed Al-Ghonaim, Hussam F. Alfaleh, Joseph P. Cal, Nazmi Said 617 Pulmonary function assessment in the early phase of patients with smoke inhalation injury from fire Cheol-Hong Kim, Heungjeong Woo, In Gyu Hyun, Won Jun Song, Changhwan Kim, Jeong-Hee Choi, Dong-Gyu Kim, Myung Goo Lee, Ki-Suck Jung 625 A comparison between the efficiency of the Xpert MTB/RIF assay and nested PCR in identifying Mycobacterium tuberculosis during routine clinical practice Cheol-Hong Kim, Heungjeong Woo, In Gyu Hyun, Changhwan Kim, Jeong-Hee