Fatty Acids: Structures and Introductory Article Properties Article Contents

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Fatty Acids: Structures and Introductory Article Properties Article Contents Fatty Acids: Structures and Introductory article Properties Article Contents . Introduction Arild C Rustan, University of Oslo, Oslo, Norway . Overview of Fatty Acid Structure . Major Fatty Acids Christian A Drevon, University of Oslo, Oslo, Norway . Metabolism of Fatty Acids . Properties of Fatty Acids Fatty acids play a key role in metabolism: as a metabolic fuel, as a necessary component of . Requirements for and Uses of Fatty Acids in Human all membranes, and as a gene regulator. In addition, fatty acids have a number of industrial Nutrition uses. Uses of Fatty Acids in the Pharmaceutical/Personal Hygiene Industries Introduction doi: 10.1038/npg.els.0003894 Fatty acids, both free and as part of complex lipids, play a number of key roles in metabolism – major metabolic fuel (storage and transport of energy), as essential components subsequent one the b carbon. The letter n is also often used of all membranes, and as gene regulators (Table 1). In ad- instead of the Greek o to indicate the position of the double dition, dietary lipids provide polyunsaturated fatty acids bond closest to the methyl end. The systematic nomencla- (PUFAs) that are precursors of powerful locally acting ture for fatty acids may also indicate the location of double metabolites, i.e. the eicosanoids. As part of complex lipids, bonds with reference to the carboxyl group (D). Figure 2 fatty acids are also important for thermal and electrical outlines the structures of different types of naturally insulation, and for mechanical protection. Moreover, free occurring fatty acids. fatty acids and their salts may function as detergents and soaps owing to their amphipathic properties and the for- Saturated fatty acids mation of micelles. Saturated fatty acids are ‘filled’ (saturated) with hydrogen. Most saturated fatty acids are straight hydrocarbon chains with an even number of carbon atoms. The most common Overview of Fatty Acid Structure fatty acids contain 12–22 carbon atoms. Fatty acids are carbon chains with a methyl group at one end of the molecule (designated omega, o) and a carboxyl Unsaturated fatty acids group at the other end (Figure 1). The carbon atom next to the carboxyl group is called the a carbon, and the Monounsaturated fatty acids have one carbon–carbon double bond, which can occur in different positions. The most common monoenes have a chain length of 16–22 and Table 1 Functions of fatty acids a double bond with the cis configuration. This means that the hydrogen atoms on either side of the double bond are 21 Energy – high per gram (37 kJ g fat) oriented in the same direction. Trans isomers may be pro- Transportable form of energy – blood lipids (e.g. triacyl- duced during industrial processing (hydrogenation) of un- glycerol in lipoproteins) saturated oils and in the gastrointestinal tract of Storage of energy, e.g. in adipose tissue and skeletal muscle ruminants. The presence of a double bond causes restric- Component of cell membranes (phospholipids) tion in the mobility of the acyl chain at that point. The cis Insulation – thermal, electrical and mechanical configuration gives a kink in the molecular shape and cis Signals – eicosanoids, gene regulation (transcription) fatty acids are thermodynamically less stable than the trans forms. The cis fatty acids have lower melting points than the trans fatty acids or their saturated counterparts. In polyunsaturated fatty acids (PUFAs) the first double CH3 – (CH2 )n CH2 – CH2 – COOH ω β α bond may be found between the third and the fourth car- bon atom from the o carbon; these are called o-3 fatty Figure 1 Nomenclature for fatty acids. Fatty acids may be named acids. If the first double bond is between the sixth and according to systematic or trivial nomenclature. One systematic way to describe fatty acids is related to the methyl (o) end. This is used to describe seventh carbon atom, then they are called o-6 fatty acids. the position of double bonds from the end of the fatty acid. The letter n is The double bonds in PUFAs are separated from each other also often used to describe the o position of double bonds. by a methylene grouping. ENCYCLOPEDIA OF LIFE SCIENCES & 2005, John Wiley & Sons, Ltd. www.els.net 1 Fatty Acids: Structures and Properties ω-characteristics Methyl endCarboxyl Saturation ∆-characteristics end Stearic 18:0 COOH Saturate 18:0 9 9 COOH Monoene 18:1 ∆9 Oleic 18:1, ω-9 Linoleic 18:2, ω-6 COOH Polyene 18:2 ∆9,12 6 9 3 15 12 9 COOH Polyene 18:3 ∆9,12,15 α-Linolenic 18:3, ω-3 3 17 14 11 5 8 EPA 20:5, ω-3 COOH Polyene 20:5 ∆5,8,11,14,17 3 19 16 13 10 7 4 DHA 22:6, ω-3 COOH Polyene 20:6 ∆4,7,10,13,16,19 Figure 2 Structure of different unbranched fatty acids with a methyl end and a carboxyl (acidic) end. Stearic acid is a trivial name for a saturated fatty acid with 18 carbon atoms and no double bonds (18:0). Oleic acid has 18 carbon atoms and one double bond in the o-9 position (18:1 o-9), whereas eicosapentaenoic acid (EPA), with multiple double bonds, is represented as 20:5 o-3. This numerical scheme is the systematic nomenclature most commonly used. It is also possible to describe fatty acids systematically in relation to the acidic end of the fatty acids; symbolized D (Greek delta) and numbered 1. All unsaturated fatty acids are shown with cis configuration of the double bonds. DHA, docosahexaenoic acid. PUFAs, which are produced only by plants and phyto- ω-6 Fatty acids Enzymes ω-3 Fatty acids plankton, are essential to all higher organisms, including Linoleic 18:2 α-Linolenic 18:3 ∆6 mammals and fish. o-3 and o-6 fatty acids cannot be in- -desaturase terconverted, and both are essential nutrients. PUFAs are γ-Linolenic 18:3 Octadecatetraenoic 18:4 further metabolized in the body by the addition of carbon elongase atoms and by desaturation (extraction of hydrogen). Dihomo-γ-linolenic 20:3 Eicosatetraenoic 20:4 Mammals have desaturases that are capable of removing ∆ 5 -desaturase hydrogens only from carbon atoms between an existing Arachidonic 20:4 Eicosapentaenoic 20:5 double bond and the carboxyl group (Figure 3). b-oxidation elongase of fatty acids may take place in either mitochondria or Adrenic 22:4 Docosapentaenoic 22:5 elongase peroxisomes. Tetracosatetraenoic 24:4 Tetracosapentaenoic 24:5 ∆6-desaturase Tetracosapentaenoic 24:5 Tetracosahexaenoic 24:6 β -oxidation Major Fatty Acids Docosapentaenoic 22:5 Docosahexaenoic 22:6 Figure 3 Synthesis of o-3 and o-6 polyunsaturated fatty acids (PUFAs). Fatty acids represent 30–35% of total energy intake in There are two families of essential fatty acids that are metabolized in the many industrial countries and the most important dietary body as shown in this figure. Retroconversion, e.g. DHA!EPA also takes sources of fatty acids are vegetable oils, dairy products, place. meat products, grain and fatty fish or fish oils. The most common saturated fatty acid in animals, membrane phospholipids throughout the animal king- plants and microorganisms is palmitic acid (16:0). Stearic dom, but very little is found in the diet. a-Linolenic acid acid (18:0) is a major fatty acid in animals and some fungi, (18:3 o-3) is found in higher plants (soyabean oil and rape and a minor component in most plants. Myristic acid (14:0) seed oils) and algae. Eicosapentaenoic acid (EPA; 20:5 o-3) has a widespread occurrence, occasionally as a major com- and docosahexaenoic acid (DHA; 22:6 o-3) are major fatty ponent. Shorter-chain saturated acids with 8–10 carbon acids of marine algae, fatty fish and fish oils; for example, atoms are found in milk and coconut triacylglycerols. DHA is found in high concentrations, especially in Oleic acid (18:1 o-9) is the most common monoenoic phospholipids in the brain, retina and testes. fatty acid in plants and animals. It is also found in micro- organisms. Palmitoleic acid (16:1 o-7) also occurs widely in animals, plants and microorganisms, and is a major com- ponent in some seed oils. Metabolism of Fatty Acids Linoleic acid (18:2 o-6) is a major fatty acid in plant lipids. In animals it is derived mainly from dietary plant An adult consumes approximately 85 g of fat daily, most of oils. Arachidonic acid (20:4 o-6) is a major component of it as triacylglycerols. During digestion, free fatty acids 2 Fatty Acids: Structures and Properties FFA Albumin ATP formation and heat dissipation Transporter Mitochondrion FABP Oxidation Peroxisome ACBP Glucose Glucose FFA Acyl-CoA Lipogenesis Activation Esterification • Gene interaction • Eicosanoids Phospholipids • Modulation of Triglycerides enzymes/proteins • Elongation/desaturation Cholesteryl esters Figure 4 Metabolism of fatty acids. Free fatty acids (FFA) are taken up into cells mainly by protein carriers in the plasma membrane and transported intracellularly via fatty acid-binding proteins (FABP). FFA are activated (acyl-CoA) before they can be shuttled via acyl-CoA binding protein (ACBP) to mitochondria or peroxisomes for b-oxidation (formation of energy as ATP and heat), or to endoplasmic reticulum for esterification to different lipid classes. Acyl-CoA or certain FFA may bind to transcription factors that regulate gene expression or may be converted to signalling molecules (eicosanoids). Glucose may be transformed to fatty acids if there is a surplus of glucose/energy in the cells. (FFA) and monoacylglycerols are released and absorbed as potassium or sodium salts. Thus, the actual water sol- in the small intestine. In the intestinal mucosa cells, FFA ubility, particularly of longer-chain acids, is often very are re-esterified to triacylglycerols, which are transported difficult to determine since it is markedly influenced by pH, via lymphatic vessels to the circulation as part of chylo- and also because fatty acids have a tendency to associate, microns.
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