Directive No. 10 Relief from Customs Import Duty
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Pharmacology on Your Palms CLASSIFICATION of the DRUGS
Pharmacology on your palms CLASSIFICATION OF THE DRUGS DRUGS FROM DRUGS AFFECTING THE ORGANS CHEMOTHERAPEUTIC DIFFERENT DRUGS AFFECTING THE NERVOUS SYSTEM AND TISSUES DRUGS PHARMACOLOGICAL GROUPS Drugs affecting peripheral Antitumor drugs Drugs affecting the cardiovascular Antimicrobial, antiviral, Drugs affecting the nervous system Antiallergic drugs system antiparasitic drugs central nervous system Drugs affecting the sensory Antidotes nerve endings Cardiac glycosides Antibiotics CNS DEPRESSANTS (AFFECTING THE Antihypertensive drugs Sulfonamides Analgesics (opioid, AFFERENT INNERVATION) Antianginal drugs Antituberculous drugs analgesics-antipyretics, Antiarrhythmic drugs Antihelminthic drugs NSAIDs) Local anaesthetics Antihyperlipidemic drugs Antifungal drugs Sedative and hypnotic Coating drugs Spasmolytics Antiviral drugs drugs Adsorbents Drugs affecting the excretory system Antimalarial drugs Tranquilizers Astringents Diuretics Antisyphilitic drugs Neuroleptics Expectorants Drugs affecting the hemopoietic system Antiseptics Anticonvulsants Irritant drugs Drugs affecting blood coagulation Disinfectants Antiparkinsonian drugs Drugs affecting peripheral Drugs affecting erythro- and leukopoiesis General anaesthetics neurotransmitter processes Drugs affecting the digestive system CNS STIMULANTS (AFFECTING THE Anorectic drugs Psychomotor stimulants EFFERENT PART OF THE Bitter stuffs. Drugs for replacement therapy Analeptics NERVOUS SYSTEM) Antiacid drugs Antidepressants Direct-acting-cholinomimetics Antiulcer drugs Nootropics (Cognitive -
Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DIX to the HTSUS—Continued
20558 Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DEPARMENT OF THE TREASURY Services, U.S. Customs Service, 1301 TABLE 1.ÐPHARMACEUTICAL APPEN- Constitution Avenue NW, Washington, DIX TO THE HTSUSÐContinued Customs Service D.C. 20229 at (202) 927±1060. CAS No. Pharmaceutical [T.D. 95±33] Dated: April 14, 1995. 52±78±8 ..................... NORETHANDROLONE. A. W. Tennant, 52±86±8 ..................... HALOPERIDOL. Pharmaceutical Tables 1 and 3 of the Director, Office of Laboratories and Scientific 52±88±0 ..................... ATROPINE METHONITRATE. HTSUS 52±90±4 ..................... CYSTEINE. Services. 53±03±2 ..................... PREDNISONE. 53±06±5 ..................... CORTISONE. AGENCY: Customs Service, Department TABLE 1.ÐPHARMACEUTICAL 53±10±1 ..................... HYDROXYDIONE SODIUM SUCCI- of the Treasury. NATE. APPENDIX TO THE HTSUS 53±16±7 ..................... ESTRONE. ACTION: Listing of the products found in 53±18±9 ..................... BIETASERPINE. Table 1 and Table 3 of the CAS No. Pharmaceutical 53±19±0 ..................... MITOTANE. 53±31±6 ..................... MEDIBAZINE. Pharmaceutical Appendix to the N/A ............................. ACTAGARDIN. 53±33±8 ..................... PARAMETHASONE. Harmonized Tariff Schedule of the N/A ............................. ARDACIN. 53±34±9 ..................... FLUPREDNISOLONE. N/A ............................. BICIROMAB. 53±39±4 ..................... OXANDROLONE. United States of America in Chemical N/A ............................. CELUCLORAL. 53±43±0 -
Wo 2008/127291 A2
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date PCT (10) International Publication Number 23 October 2008 (23.10.2008) WO 2008/127291 A2 (51) International Patent Classification: Jeffrey, J. [US/US]; 106 Glenview Drive, Los Alamos, GOlN 33/53 (2006.01) GOlN 33/68 (2006.01) NM 87544 (US). HARRIS, Michael, N. [US/US]; 295 GOlN 21/76 (2006.01) GOlN 23/223 (2006.01) Kilby Avenue, Los Alamos, NM 87544 (US). BURRELL, Anthony, K. [NZ/US]; 2431 Canyon Glen, Los Alamos, (21) International Application Number: NM 87544 (US). PCT/US2007/021888 (74) Agents: COTTRELL, Bruce, H. et al.; Los Alamos (22) International Filing Date: 10 October 2007 (10.10.2007) National Laboratory, LGTP, MS A187, Los Alamos, NM 87545 (US). (25) Filing Language: English (81) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of national protection available): AE, AG, AL, AM, AT,AU, AZ, BA, BB, BG, BH, BR, BW, BY,BZ, CA, CH, (30) Priority Data: CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, 60/850,594 10 October 2006 (10.10.2006) US ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, (71) Applicants (for all designated States except US): LOS LR, LS, LT, LU, LY,MA, MD, ME, MG, MK, MN, MW, ALAMOS NATIONAL SECURITY,LLC [US/US]; Los MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, Alamos National Laboratory, Lc/ip, Ms A187, Los Alamos, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, NM 87545 (US). -
Tariff Schedule of Canada
Tariff Schedule of Canada Tariff Item Description of Goods Base Rate Staging Category 0101.10.00 Pure-bred breeding animals Free A 0101.90.00 Other Free A 0102.10.00 Pure-bred breeding animals Free A 0102.90.00 Other Free A 0103.10.00 Pure-bred breeding animals Free A 0103.91.00 Weighing less than 50 kg Free A 0103.92.00 Weighing 50 kg or more Free A 0104.10.00 Sheep Free A 0104.20.00 Goats Free A 0105.11.10 For breeding purposes Free A 0105.11.21 Broilers for domestic production: Within access 0.86¢ each A commitment 0105.11.22 Broilers for domestic production: Over access 238% but not less E commitment than 30.8¢ each 0105.11.90 Other Free A 0105.12.10 For breeding purposes Free A 0105.12.90 Other 8% A 0105.19.10 For breeding purposes Free A 0105.19.92 Other: Guinea fowls 2.5% A 0105.19.93 Other: Ducks and geese 8% A 0105.94.10 For breeding purposes; 2.82¢/kg A Spent fowl; Started pullets 0105.94.91 Other: Within access commitment 1.90¢/kg C 0105.94.92 Other: Over access commitment 238% but not less E than $1.25/kg 0105.99.11 Turkeys: Within access commitment 1.90¢/kg C 0105.99.12 Turkeys: Over access commitment 154.5% but not less E than $1.60/kg 0105.99.90 Other 3% A 0106.11.00 Primates Free A 0106.12.00 Whales, dolphins and porpoises (mammals of the order Free A Cetacea); manatees and dugongs (mammals of the order Sirenia) 0106.19.00 Other Free A 0106.20.00 Reptiles (including snakes and turtles) Free A 0106.31.00 Birds of prey Free A 0106.32.00 Psittaciformes (including parrots, parakeets, macaws and Free A cockatoos) 0106.39.00 -
Advanced Drug Development and Manufacturing
(19) & (11) EP 2 511 844 A2 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 17.10.2012 Bulletin 2012/42 G06F 21/00 (2006.01) G21K 7/00 (2006.01) (21) Application number: 12164870.3 (22) Date of filing: 10.10.2007 (84) Designated Contracting States: • Warner, Benjamin, P. AT BE BG CH CY CZ DE DK EE ES FI FR GB GR Los Alamos, NM 87544 (US) HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE • McCleskey, Mark, T. SI SK TR Los Alamos, NM 87544 (US) • Berger, Jennifer, A. (30) Priority: 10.10.2006 US 850594 P Los Alamos, NM 87544 (US) • Stewart, Jeffrey, J. (62) Document number(s) of the earlier application(s) in Los Alamos, NM 87544 (US) accordance with Art. 76 EPC: • Harris, Michael, N. 07874491.9 / 2 084 519 Los Alamos, NM 87544 (US) • Burrell, Anthony, K. (71) Applicants: Los Alamos, NM 87544 (US) • Los Alamos National Security, LLC Los Alamos, NM 87545 (US) (74) Representative: Beckmann, Claus et al • Caldera Pharmaceuticals, INC. Kraus & Weisert Los Alamos, NM 87544 (US) Patent- und Rechtsanwälte Thomas-Wimmer-Ring 15 (72) Inventors: 80539 München (DE) • Birnbaum, Eva, R. Los Alamos, NM 87544 (US) Remarks: • Koppisch, Andrew, T. This application was filed on 20-04-2012 as a Los Alamos, NM 87544 (US) divisional application to the application mentioned • Baldwin, Sharon, M. under INID code 62. Santa Fe, NM 87507 (US) (54) Advanced drug development and manufacturing (57) There is described an apparatus for measuring molecule with the polychromatic X-rays and a security protein characteristics comprising an X-ray fluorescence system for maintaining records for the data from the plu- (XRF) spectrometer comprising a source of polychromat- rality of X-ray fluorescence signal measurements. -
Harmonized Tariff Schedule of the United States (2004) -- Supplement 1 Annotated for Statistical Reporting Purposes
Harmonized Tariff Schedule of the United States (2004) -- Supplement 1 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2004) -- Supplement 1 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. Product CAS No. Product CAS No. ABACAVIR 136470-78-5 ACEXAMIC ACID 57-08-9 ABAFUNGIN 129639-79-8 ACICLOVIR 59277-89-3 ABAMECTIN 65195-55-3 ACIFRAN 72420-38-3 ABANOQUIL 90402-40-7 ACIPIMOX 51037-30-0 ABARELIX 183552-38-7 ACITAZANOLAST 114607-46-4 ABCIXIMAB 143653-53-6 ACITEMATE 101197-99-3 ABECARNIL 111841-85-1 ACITRETIN 55079-83-9 ABIRATERONE 154229-19-3 ACIVICIN 42228-92-2 ABITESARTAN 137882-98-5 ACLANTATE 39633-62-0 ABLUKAST 96566-25-5 ACLARUBICIN 57576-44-0 ABUNIDAZOLE 91017-58-2 ACLATONIUM NAPADISILATE 55077-30-0 ACADESINE 2627-69-2 ACODAZOLE 79152-85-5 ACAMPROSATE 77337-76-9 ACONIAZIDE 13410-86-1 ACAPRAZINE 55485-20-6 ACOXATRINE 748-44-7 ACARBOSE 56180-94-0 ACREOZAST 123548-56-1 ACEBROCHOL 514-50-1 ACRIDOREX 47487-22-9 ACEBURIC ACID 26976-72-7 -
(12) United States Patent (10) Patent No.: US 8,882,729 B2 Horstmann Et Al
US008882729B2 (12) United States Patent (10) Patent No.: US 8,882,729 B2 Horstmann et al. (45) Date of Patent: Nov. 11, 2014 (54) TRANSDERMAL THERAPEUTIC SYSTEM (56) References Cited HAVING STABILIZED MEMBRANE U.S. PATENT DOCUMENTS (75) Inventors: Michael Horstmann, Neuwied (DE); 4,781,924 A 11/1988 Lee et al. Patrick Mohr, Breisig (DE); 5,215,751 A 6/1993 Muller et al. Mohammad Sameti, Bonn (DE) 6,221,383 B1 * 4/2001 Miranda et al. ............... 424/449 6,620,429 B1 9, 2003 Muller et al. 6,884,434 B1 4/2005 Muller et al. (73) Assignee: LTS Lohmann Therapie Systeme AG, 7, 175,853 B1 2, 2007 Bracht Andernach (DE) 2004/O253.299 A1 12/2004 Beier et al. 2005/O169977 A1* 8/2005 Kanios et al. ................. 424/449 (*) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 FOREIGN PATENT DOCUMENTS U.S.C. 154(b) by 779 days. DE 39 05 050 8, 1990 DE 39 05 051 8, 1990 (21) Appl. No.: 12/921,988 DE 19814 083 10, 1999 DE 19814 084 10, 1999 DE 19814 087 10, 1999 (22) PCT Filed: Feb. 28, 2009 EP O 316 065 5, 1989 WO WO 93/10772 6, 1993 (86). PCT No.: PCT/EP2O09/OO1446 WO WO, 96/39 136 12/1996 WO WO 97.11696 4f1997 S371 (c)(1), WO WOO3,O11291 2, 2003 (2), (4) Date: Dec. 15, 2011 OTHER PUBLICATIONS (87) PCT Pub. No.: WO2009/112167 International Search Repot dated Jun. 17, 2009, 4pgs. PCT Pub. -
Chemical Structure-Related Drug-Like Criteria of Global Approved Drugs
Molecules 2016, 21, 75; doi:10.3390/molecules21010075 S1 of S110 Supplementary Materials: Chemical Structure-Related Drug-Like Criteria of Global Approved Drugs Fei Mao 1, Wei Ni 1, Xiang Xu 1, Hui Wang 1, Jing Wang 1, Min Ji 1 and Jian Li * Table S1. Common names, indications, CAS Registry Numbers and molecular formulas of 6891 approved drugs. Common Name Indication CAS Number Oral Molecular Formula Abacavir Antiviral 136470-78-5 Y C14H18N6O Abafungin Antifungal 129639-79-8 C21H22N4OS Abamectin Component B1a Anthelminithic 65195-55-3 C48H72O14 Abamectin Component B1b Anthelminithic 65195-56-4 C47H70O14 Abanoquil Adrenergic 90402-40-7 C22H25N3O4 Abaperidone Antipsychotic 183849-43-6 C25H25FN2O5 Abecarnil Anxiolytic 111841-85-1 Y C24H24N2O4 Abiraterone Antineoplastic 154229-19-3 Y C24H31NO Abitesartan Antihypertensive 137882-98-5 C26H31N5O3 Ablukast Bronchodilator 96566-25-5 C28H34O8 Abunidazole Antifungal 91017-58-2 C15H19N3O4 Acadesine Cardiotonic 2627-69-2 Y C9H14N4O5 Acamprosate Alcohol Deterrant 77337-76-9 Y C5H11NO4S Acaprazine Nootropic 55485-20-6 Y C15H21Cl2N3O Acarbose Antidiabetic 56180-94-0 Y C25H43NO18 Acebrochol Steroid 514-50-1 C29H48Br2O2 Acebutolol Antihypertensive 37517-30-9 Y C18H28N2O4 Acecainide Antiarrhythmic 32795-44-1 Y C15H23N3O2 Acecarbromal Sedative 77-66-7 Y C9H15BrN2O3 Aceclidine Cholinergic 827-61-2 C9H15NO2 Aceclofenac Antiinflammatory 89796-99-6 Y C16H13Cl2NO4 Acedapsone Antibiotic 77-46-3 C16H16N2O4S Acediasulfone Sodium Antibiotic 80-03-5 C14H14N2O4S Acedoben Nootropic 556-08-1 C9H9NO3 Acefluranol Steroid -
Annex I Headnote 1. the Schedule of a Party Sets Out, Pursuant to Article
Annex I Headnote 1. The Schedule of a Party sets out, pursuant to Article 809 (Investment - Non- Conforming Measures) and Article 906 (Cross-Border Trade in Services - Non- Conforming Measures), the reservations taken by that Party with respect to existing measures by a Party that do not conform with obligations imposed by: (a) Articles 803, 902 (Investment, Cross-Border Trade in Services - National Treatment); (b) Articles 804, 903 (Investment, Cross-Border Trade in Services - Most- Favoured-Nation Treatment); (c) Article 905 (Cross-Border Trade in Services - Local Presence); (d) Article 807 (Investment - Performance Requirements); (e) Article 808 (Investment - Senior Management and Boards of Directors); (f) Article 904 (Cross-Border Trade in Services - Market Access); and, in certain cases, sets out commitments for immediate or future liberalization. 2. Each reservation sets out the following elements: (a) Sector refers to the general sector in which the reservation is taken; (b) Sub-Sector refers to the specific sector in which the reservation is taken; (c) Industry Classification refers, where applicable, to the activity covered by the reservation according to domestic industry classification codes; (d) Type of Reservation specifies the obligation referred to in paragraph 1 for which a reservation is taken; (e) Measures identifies the laws, regulations or other measures, as qualified, where indicated, by the Description element, for which the reservation is taken. A measure cited in the Measures element: (i) means the measure as amended, continued or renewed as of the date of entry into force of this Agreement, and (ii) includes any subordinate measure adopted or maintained under the authority of and consistent with the measure; (f) Description sets out commitments, if any, for liberalization on the date of entry into force of this Agreement, and the remaining non-conforming aspects of the existing measures for which the reservation is taken. -
Harmonized Tariff Schedule of the United States (2006) (Rev
Harmonized Tariff Schedule of the United States (2006) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2006) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. Product CAS No. Product CAS No. ABACAVIR 136470-78-5 ACEXAMIC ACID 57-08-9 ABAFUNGIN 129639-79-8 ACICLOVIR 59277-89-3 ABAMECTIN 65195-55-3 ACIFRAN 72420-38-3 ABANOQUIL 90402-40-7 ACIPIMOX 51037-30-0 ABARELIX 183552-38-7 ACITAZANOLAST 114607-46-4 ABCIXIMAB 143653-53-6 ACITEMATE 101197-99-3 ABECARNIL 111841-85-1 ACITRETIN 55079-83-9 ABIRATERONE 154229-19-3 ACIVICIN 42228-92-2 ABITESARTAN 137882-98-5 ACLANTATE 39633-62-0 ABLUKAST 96566-25-5 ACLARUBICIN 57576-44-0 ABUNIDAZOLE 91017-58-2 ACLATONIUM NAPADISILATE 55077-30-0 ACADESINE 2627-69-2 ACODAZOLE 79152-85-5 ACAMPROSATE 77337-76-9 ACONIAZIDE 13410-86-1 ACAPRAZINE 55485-20-6 ACOXATRINE 748-44-7 ACARBOSE 56180-94-0 ACREOZAST 123548-56-1 ACEBROCHOL 514-50-1 ACRIDOREX 47487-22-9 ACEBURIC ACID 26976-72-7 ACRIFLAVINIUM -
(12) Patent Application Publication (10) Pub. No.: US 2004/0241219 A1 Hille Et Al
US 2004O241219A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2004/0241219 A1 Hille et al. (43) Pub. Date: Dec. 2, 2004 (54) TRANSDERMAL THERAPEUTIC SYSTEM (86) PCT No.: PCT/EP02/09057 BASED ON POLYACRYLATE-CONTACT-BONDING (30) Foreign Application Priority Data ADHESIVES WITHOUT FUNCTIONAL GROUPS Aug. 24, 2001 (DE)......................................... 101.41652O (76) Inventors: Thomas Hille, Neuwied (DE); Frank Publication Classification Theobald, Bad Breisig (DE); Ursula Hildegard Klein, Neuwied (DE) (51) Int. Cl." ....................................................... A61K 9/70 (52) U.S. Cl. .............................................................. 424/449 Correspondence Address: William F Lawrence (57) ABSTRACT Frommer Lawrence & Haug The invention relates to a transdermal therapeutic System 745 Fifth Avenue (TTS) consisting of a rear layer, a protective layer and an New York, NY 10151 (US) active-Substance-containing polymer layer. The polymer matrix comprises a polyacrylate which contains an (21) Appl. No.: 10/487,380 extremely reduced number of functional groups. In one particular embodiment, the polyacrylate is free from (22) PCT Filed: Aug. 13, 2002 hydroxyl groups and/or carboxyl groups. US 2004/0241219 A1 Dec. 2, 2004 TRANSIDERMAL THERAPEUTIC SYSTEM BASED are both produced by National Starch. These polyacrylates ON POLYACRYLATE-CONTACT-BONDING have proven to be stable and highly tolerable contact ADHESIVES WITHOUT FUNCTIONAL GROUPS adhesive polymers for the production of transdermal thera peutic Systems which contain Steroid hormones as active 0001 Transdermal therapeutic systems (TTS) are flat compounds. pharmaceutical products built up in layers, in which one or more active compounds are embedded in an optionally 0007. A disadvantage in the case of the transdermal contact-adhesive polymer matrix with or without excipients therapeutic Systems whose polymer matrices contain poly (e.g. -
(12) Patent Application Publication (10) Pub. No.: US 2008/0220441 A1 Birnbaum Et Al
US 20080220441A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2008/0220441 A1 Birnbaum et al. (43) Pub. Date: Sep. 11, 2008 (54) ADVANCED DRUG DEVELOPMENT AND Related U.S. Application Data MANUFACTURING (63) Continuation-in-part of application No. 09/859,701, filed on May 16, 2001, Continuation-in-part of appli (76) Inventors: Eva R. Birnbaum, Los Alamos, cation No. 10/206,524, filed on Jul. 25, 2002, now NM (US); Andrew T. Koppisch, abandoned, Continuation-in-part of application No. Flagstaff, AZ (US); Sharon M. 10/621,825, filed on Jul. 16, 2003, now Pat. No. 6,858, Baldwin, Santa Fe, NM (US); 148. Benjamin P. Warner, Los Alamos, (60) Provisional application No. 60/850,594, filed on Oct. NM (US); T. Mark McCleskey, 10, 2006. Los Alamos, NM (US); Jeffrey Joseph Stewart, Los Alamos, NM Publication Classification (US); Jennifer A. Berger, Los (51) Int. C. Alamos, NM (US); Michael N. GOIN 33/53 (2006.01) Harris, Los Alamos, NM (US); GOIN 2L/76 (2006.01) Anthony K. Burrell, Los Alamos, GOIN 33/68 (2006.01) NM (US) GOIN 23/223 (2006.01) (52) U.S. Cl. ............ 435/7.1; 436/501; 436/172:436/86; Correspondence Address: 378/45 LOSALAMOS NATIONAL SECURITY, LLC (57) ABSTRACT LOS ALAMOS NATIONAL LABORATORY, PPO. BOX 1663, LC/IP, MS A187 X-ray fluorescence (XRF) spectrometry has been used for LOSALAMOS, NM 87545 (US) detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical, for estimating (21) Appl.