FRAC Code List ©*2021: Fungal Control Agents Sorted by Cross Resistance Pattern and Mode of Action (Including Coding for FRAC Groups on Product Labels)

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FRAC Code List ©*2021: Fungal control agents sorted by cross resistance pattern and mode of action (including coding for FRAC Groups on product labels)

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INTRODUCTION

The following table lists fungicides, mainly for use in plant protection, according to their mode of action and resistance risk. The most important bactericides are also included. Grouping is considering the biochemical mode of action, but a main driver is to identify cross-resistance patterns between chemistries.

The Table headings are defined as:

MOA Code Different letters (A to P, with added numbers) are used to distinguish fungicide groups according to their biochemical mode of action (MOA) in the biosynthetic pathways of plant pathogens. The grouping was made according to processes in the metabolism starting from nucleic acids synthesis (A) to secondary metabolism, e.g. melanin synthesis (I), followed by host plant defence inducers (P), recent molecules with an unknown mode of action and unknown resistance risk (U, transient status, until information about mode of action and mechanism of resistance becomes available), and chemical multi-site inhibitors (M). Fungicidal compositions of biological origin are grouped according to the main mode of action within the respective pathway categories. A more recently introduced category “Biologicals with multiple modes of action” (BM) is used for agents from biological origin showing multiple mechanisms of action.

Target Site and Code If available, the biochemical mode of action is given. In several cases the precise target site may not be known, however, a grouping within a given pathway / functional cluster is still possible. Grouping can also be made due to cross resistance profiles within a group or in relation to other groups.

Group Name The Group Names listed are based on chemical relatedness of structures which are accepted in literature (e.g. The Pesticide Manual). They are based on different sources (chemical structure, site of action, first important representative in group).

Chemical or Biological Group Grouping is based on chemical considerations. Nomenclature is according to IUPAC and Chemical Abstract name. Taxonomic information may be used for agents of biological origin.

Common name BSI/ISO accepted (or proposed) common name for an individual active ingredient expected to appear on the product label as definition of the product.

Comments on Resistance Details are given for the (molecular) mechanism of resistance and the resistance risk. If field- resistance is known to one member of the Group, it is most likely but not exclusively valid that cross resistance to other group members will be present. There is increasing evidence that the degree of cross resistance can differ between group members and pathogen species or even within species. For the latest information on resistance and cross resistance status of a pathogen / fungicide combination, it is advised to contact local FRAC representatives, product manufacturer’s representatives or crop protection advisors. The intrinsic risk for resistance evolution to a given fungicide group is estimated to be low, medium or high according to the principles described in FRAC Monographs 1, 2 and 3. Resistance management is driven by intrinsic risk of fungicide, pathogen risk and agronomic risk (see FRAC pathogen risk list).

Similar classification lists of fungicides have been published by T. Locke on behalf of FRAG – UK (Fungicide Resistance, August 2001), and by P. Leroux (Classification des fongicides agricoles et résistance, Phytoma, La Défense des Végétaux, No. 554, 43-51, November 2002).

FRAC Code Numbers and letters are used to distinguish the fungicide groups according to their cross-resistance behaviour. This code should be used to define the “FUNGICIDE GROUP” code, e.g. on product labels. The numbers were assigned primarily according to the time of product introduction to the market. The letters refer to P = host plant defence inducers, M = chemical multi-site inhibitors, U = unknown mode of action and unknown resistance risk, and BM = biologicals with multiple modes of action. Reclassification of compounds based on new research may result in codes to expire. This is most likely in the U – section when the mode of action gets clarified. These codes are not re-used for new groups; a note is added to indicate reclassification into a new code.

Last update: March 2021 Next update decisions: February 2022

* Disclaimer The FRAC Code List is the property of FRAC and protected by copyright laws. The FRAC Code List may be used for educational purposes without permission from FRAC. Commercial use of this material may only be made with the express, prior, and written permission of FRAC.

MOA TARGET SITE GROUP NAME CHEMICAL OR COMMON NAME COMMENTS FRAC AND CODE BIOLOGICAL GROUP CODE benalaxyl benalaxyl-M Resistance and cross resistance (=kiralaxyl) well known in various acylalanines furalaxyl Oomycetes but mechanism

A1 unknown. PA – fungicides metalaxyl

(PhenylAmides) metalaxyl-M 4 RNA polymerase I (=mefenoxam) High risk. See FRAC Phenylamide oxazolidinones oxadixyl Guidelines for resistance management

butyrolactones ofurace metabolism A2 Medium risk. Resistance and hydroxy- bupirimate cross resistance known in hydroxy- (2-amino-) dimethirimol powdery mildews. (2-amino-) pyrimidines 8 adenosin- pyrimidines ethirimol Resistance management deaminase required. A3 isoxazoles hymexazole DNA/RNA synthesis heteroaromatics Resistance not known. 32

A: nucleic acids A: (proposed) isothiazolones octhilinone A4 Bactericide. Resistance known. Risk in fungi unknown. carboxylic acids carboxylic acids oxolinic acid 31 DNA topoisomerase Resistance management type II (gyrase) required.

MOA TARGET SITE GROUP NAME CHEMICAL OR COMMON NAME COMMENTS FRAC AND CODE BIOLOGICAL GROUP CODE Resistance common in many benomyl fungal species. Several target carbendazim benzimidazoles site mutations, mostly fuberidazole E198A/G/K, F200Y in β-tubulin thiabendazole MBC - gene. B1 fungicides Positive cross resistance ß-tubulin assembly (Methyl between the group members. 1 in mitosis Benzimidazole Negative cross resistance to Carbamates) thiophanate N-phenyl carbamates. thiophanates thiophanate-methyl High risk. See FRAC Benzimidazole Guidelines for resistance management. Resistance known. Target site mutation E198K. Negative cross B2 N-phenyl N-phenyl resistance to benzimidazoles. carbamates diethofencarb ß-tubulin assembly carbamates High risk. 10

in mitosis Resistance management

protein required. benzamides toluamides zoxamide B3 Low to medium risk. Resistance management 22 ß-tubulin assembly thiazole ethylamino-thiazole- ethaboxam required. in mitosis carboxamide carboxamide B4 cell division phenylureas phenylureas pencycuron Resistance not known. 20 (unknown site) B5 Resistant isolates detected in grapevine downy mildew. pyridinylmethyl- fluopicolide delocalisation of benzamides Medium risk. benzamides fluopimomide 43 spectrin-like Resistance management B: Cytoskeleton and motor Cytoskeleton motor B: and proteins required Resistance known in Fusarium graminearum. Target site mutations in the gene coding for cyanoacrylates aminocyanoacrylates phenamacril myosin-5 found in lab studies. 47 Medium to high risk. Resistance management B6 required. actin/myosin/fimbrin Less sensitive isolates detected function benzophenone metrafenone in powdery mildews (Blumeria and Sphaerotheca) aryl-phenyl- Medium risk. ketones Resistance management 50 benzoylpyridine pyriofenone required.

Reclassified from U8 in 2018

MOA TARGET SITE GROUP NAME CHEMICAL OR COMMON NAME COMMENTS FRAC AND CODE BIOLOGICAL GROUP CODE

pyrimidinamines pyrimidinamines diflumetorim C1 pyrazole-5- pyrazole-MET1 tolfenpyrad Resistance not known. complex I NADH carboxamides 39 oxido-reductase Quinazoline quinazoline fenazaquin benodanil phenyl-benzamides flutolanil mepronil phenyl-oxo-ethyl isofetamid thiophene amide pyridinyl-ethyl- fluopyram benzamides phenyl-cyclobutyl- cyclobutrifluram pyridineamide furan- carboxamides fenfuram Resistance known for several oxathiin- carboxin fungal species in field carboxamides oxycarboxin populations and lab mutants. thiazole- thifluzamide Target site mutations in sdh carboxamides gene, e.g. H/Y (or H/L) at 257, benzovindiflupyr 267, 272 or P225L, dependent C2 SDHI bixafen on fungal species. (Succinate- complex II: fluindapyr Resistance management C. respiration C. dehydrogenase 7 succinate-dehydro- fluxapyroxad required. inhibitors) genase pyrazole-4- furametpyr carboxamides inpyrfluxam Medium to high risk. isopyrazam penflufen See FRAC SDHI Guidelines penthiopyrad for resistance management. sedaxane N-cyclopropyl-N- benzyl-pyrazole- isoflucypram carboxamides N-methoxy-(phenyl- ethyl)-pyrazole- pydiflumetofen carboxamides pyridine- boscalid carboxamides pyrazine- pyraziflumid carboxamides

MOA TARGET SITE GROUP NAME CHEMICAL OR COMMON NAME COMMENTS FRAC AND CODE BIOLOGICAL GROUP CODE azoxystrobin coumoxystrobin enoxastrobin methoxy-acrylates flufenoxystrobin picoxystrobin Resistance known in various pyraoxystrobin fungal species. Target site mutations in cyt b gene (G143A, methoxy-acetamide mandestrobin F129L) and additional pyraclostrobin mechanisms. methoxy-carbamates pyrametostrobin

triclopyricarb QoI-fungicides Cross resistance shown kresoxim-methyl 11 (Quinone outside oximino-acetates between all members of the C3 Inhibitors) trifloxystrobin Code 11 fungicides. dimoxystrobin complex III: fenaminstrobin oximino-acetamides High risk. cytochrome bc1 metominostrobin (ubiquinol oxidase) orysastrobin See FRAC QoI Guidelines at Qo site (cyt b oxazolidine-diones famoxadone gene) for resistance management. dihydro-dioxazines fluoxastrobin C. respiration C. imidazolinones fenamidone benzyl-carbamates pyribencarb

QoI-fungicides Resistance not known. Not (Quinone outside cross resistant with Code 11 Inhibitors; fungicides on G143A mutants. Subgroup A) tetrazolinones metyltetraprole 11A High risk.

See FRAC QoI Guidelines for resistance management.

MOA TARGET SITE GROUP NAME CHEMICAL OR COMMON NAME COMMENTS FRAC AND CODE BIOLOGICAL GROUP CODE Resistance risk unknown but cyano-imidazole cyazofamid assumed to be medium to high C4 (mutations at target site known QiI - fungicides in model organisms). complex III: (Quinone inside sulfamoyl-triazole amisulbrom Resistance management cytochrome bc1 Inhibitors) required. 21 (ubiquinone reductase) at Qi site fenpicoxamid No spectrum overlap with the picolinamides florylpicoxamid Oomycete-fungicides cyazofamid and amisulbrom binapacryl

dinitrophenyl- Resistance not known. meptyldinocap C5 crotonates Also acaricidal activity. dinocap uncouplers of Low risk. However, resistance 29 2,6-dinitro-anilines fluazinam oxidative phos- claimed in Botrytis in Japan. phorylation (continued) (pyr.-hydrazones) (ferimzone) Reclassified to U 14 in 2012. C6 fentin acetate inhibitors of organo tin tri-phenyl tin Some resistance cases fentin chloride oxidative phos- compounds compounds known. Low to medium risk. 30 phorylation, ATP fentin hydroxide synthase C: respiration C: C7 thiophene- thiophene- silthiofam Resistance reported. Risk low. ATP transport carboxamides carboxamides 38 (proposed) C8 Not cross resistant to QoI

complex III: QoSI fungicides fungicides. cytochrome bc1 (Quinone outside Resistance risk assumed to (ubiquinone Inhibitor, triazolo-pyrimidylamine ametoctradin be medium to high 45 reductase) at stigmatellin (single site inhibitor). Qo site, stigmatellin binding type) Resistance management binding sub-site required. Resistance known in Botrytis D1 and Venturia, sporadically in Oculimacula. methionine AP - fungicides cyprodinil anilino-pyrimidines biosynthesis (Anilino- mepanipyrim Medium risk. 9 (proposed) Pyrimidines) pyrimethanil (cgs gene) See FRAC Anilinopyrimidine Guidelines for resistance management. D2 Low to medium risk. enopyranuronic enopyranuronic acid protein synthesis blasticidin-S Resistance management acid antibiotic antibiotic 23 (ribosome, required. termination step) Resistance known in fungal D3 and bacterial (P. glumae) hexopyranosyl hexopyranosyl protein synthesis kasugamycin pathogens. Medium risk. antibiotic antibiotic 24 (ribosome, initiation Resistance management step) required. D4 Bactericide. Resistance glucopyranosyl glucopyranosyl known. High risk. protein synthesis streptomycin 25 (ribosome, initiation antibiotic antibiotic Resistance management step) required. D: amino synthesis acids D: and protein D5 Bactericide. Resistance tetracycline known. High risk. protein synthesis tetracycline antibiotic oxytetracycline 41 (ribosome, antibiotic Resistance management elongation step) required.

MOA TARGET SITE GROUP NAME CHEMICAL OR COMMON NAME COMMENTS FRAC AND CODE BIOLOGICAL GROUP CODE

Resistance to quinoxyfen aryloxyquinoline quinoxyfen known.

E1 Medium risk. aza- Resistance management signal transduction 13 (mechanism naphthalenes required. Cross resistance unknown) quinazolinone proquinazid found in Erysiphe (Uncinula)

necator but not in Blumeria

graminis. E2 Resistance found sporadically, mechanism speculative. MAP/Histidine- PP-fungicides fenpiclonil phenylpyrroles Low to medium risk. Kinase in osmotic (PhenylPyrroles) fludioxonil 12 signal transduction Resistance management (os-2, HOG1) required. Resistance common in Botrytis and some other pathogens. Several mutations in OS-1, E3 chlozolinate mostly I365S. E:signal transduction dimethachlone Cross resistance common MAP/Histidine- dicarboximides dicarboximides iprodione 2 Kinase in osmotic between the group members. procymidone signal transduction vinclozolin (os-1, Daf1) Medium to high risk. See FRAC Dicarboximide Guidelines for resistance management.

MOA TARGET SITE GROUP NAME CHEMICAL OR COMMON NAME COMMENTS FRAC AND CODE BIOLOGICAL GROUP CODE

F1 formerly dicarboximides edifenphos Resistance known in specific phosphoro- F2 phosphoro-thiolates iprobenfos (IBP) fungi. thiolates pyrazophos Low to medium risk. phospholipid Resistance management 6 biosynthesis, Dithiolanes dithiolanes isoprothiolane required if used for risky methyltransferase pathogens. biphenyl AH-fungicides chloroneb (Aromatic Resistance known in some aromatic hydrocarbons dicloran Hydrocarbons) fungi. F3 quintozene (PCNB) (chlorophenyls, Low to medium risk. tecnazene (TCNB) nitroanilines) Cross resistance patterns 14 cell peroxidation tolclofos-methyl (proposed) complex due to different activity spectra. heteroaromatics 1,2,4-thiadiazoles etridiazole

F4 iodocarb Low to medium risk. cell membrane Carbamates carbamates propamocarb Resistance management 28 permeability, fatty prothiocarb required. acids (proposed) F5 formerly CAA-fungicides F6 formerly Bacillus amyloliquefaciens strains (FRAC Code 44); microbial disrupters reclassified to BM02 in 2020 of pathogen cell membranes F7 formerly extract from Melaleuca alternifolia (tea tree oil) cell membrane and plant oils (eugenol, geraniol, thymol) disruption FRAC Code 46, reclassified to BM01 in 2021 amphoteric macrolide antifungal antibiotic Resistance not known. natamycin F8 Polyene from Streptomyces Agricultural, food and topical (pimaricin) 48 ergosterol binding natalensis or medical uses. F: lipid synthesis or transport / membrane integritylipid transport / or F: function membrane synthesis or S. chattanoogensis OSBPI Resistance risk assumed to be oxysterol binding medium to high (single site F9 piperidinyl-thiazole- oxathiapiprolin protein inhibitor). Resistance lipid homeostasis isoxazolines fluoxapiprolin 49 and transfer/storage homologue management required. inhibition (Previously U15).

MOA TARGET SITE GROUP NAME CHEMICAL OR COMMON NAME COMMENTS FRAC AND CODE BIOLOGICAL GROUP CODE piperazines triforine pyrifenox pyridines pyrisoxazole fenarimol pyrimidines nuarimol imazalil There are big differences in oxpoconazole the activity spectra of DMI imidazoles pefurazoate fungicides. prochloraz triflumizole Resistance is known in various azaconazole fungal species. Several bitertanol resistance mechanisms are bromuconazole known incl. target site cyproconazole mutations in cyp51 (erg 11) difenoconazole gene, e.g. V136A, Y137F, diniconazole A379G, I381V; cyp51 promotor; ABC transporters G1 DMI-fungicides epoxiconazole and others. (DeMethylation etaconazole

C14- demethylase Inhibitors) fenbuconazole Generally wise to accept that 3 in sterol fluquinconazole biosynthesis cross resistance is present (SBI: Class I) flusilazole (erg11/cyp51) flutriafol between DMI fungicides active hexaconazole against the same fungus. triazoles imibenconazole ipconazole DMI fungicides are Sterol mefentrifluconazole Biosynthesis Inhibitors (SBIs), metconazole but show no cross resistance myclobutanil to other SBI classes. penconazole propiconazole Medium risk. simeconazole tebuconazole See FRAC SBI Guidelines tetraconazole for resistance management. triadimefon triadimenol triticonazole

triazolinthiones prothioconazole sterol biosynthesis in sterolmembranes biosynthesis aldimorph Decreased sensitivity for

G: G: G2 dodemorph powdery mildews. morpholines fenpropimorph Cross resistance within the 14  -reductase amines tridemorph group generally found but not and (“morpholines”) to other 8 7- fenpropidin  → piperidines SBI classes. 5 piperalin isomerase (SBI: Class II) in sterol Low to medium risk. biosynthesis spiroketal-amines spiroxamine See FRAC SBI Guidelines (erg24, erg2) for resistance management. G3 KRI fungicides (KetoReductase hydroxyanilides fenhexamid Low to medium risk. 3-keto reductase, Inhibitors) Resistance management 17 C4- de-methylation amino-pyrazolinone fenpyrazamine required. (erg27) (SBI: Class III) G4 Resistance not known, thiocarbamates pyributicarb fungicidal and herbicidal activity. squalene-epoxidase (SBI class IV) 18 in sterol naftifine biosynthesis allylamines Medical fungicides only. (erg1) terbinafine

MOA TARGET SITE GROUP NAME CHEMICAL OR COMMON NAME COMMENTS FRAC AND CODE BIOLOGICAL GROUP CODE

H3 Formerly glucopyranosyl reclassified to U18 26 antibiotic (validamycin) Resistance known. H4 peptidyl pyrimidine Medium risk. polyoxins polyoxin nucleoside Resistance management 19 chitin synthase required.

dimethomorph Resistance known in cinnamic acid amides flumorph Plasmopara viticola but not in pyrimorph Phytophthora infestans. H5 CAA-fungicides benthiavalicarb Cross resistance between all (Carboxylic Acid valinamide 40 iprovalicarb members of the CAA group. cellulose synthase Amides) carbamates valifenalate Low to medium risk. H: cell H: biosynthesis wall See FRAC CAA Guidelines for mandelic acid amides mandipropamid resistance management.

I1 MBI-R isobenzo-furanone fthalide (Melanin Resistance not known. Biosynthesis pyrrolo-quinolinone pyroquilon reductase in 16.1 melanin Inhibitors – triazolobenzo- biosynthesis Reductase) tricyclazole thiazole cyclopropane- MBI-D carpropamid I2 carboxamide Resistance known. (Melanin Medium risk. Biosynthesis carboxamide diclocymet dehydratase in Resistance management 16.2 Inhibitors – melanin required. biosynthesis Dehydratase) propionamide fenoxanil

I3 MBI-P Resistance not known. (Melanin trifluoroethyl- polyketide synthase Biosynthesis carbamate tolprocarb Additional activity against in melanin Inhibitors – 16.3

I: melanin synthesis in cell wall melanin I: synthesisin bacteria and fungi through biosynthesis Polyketide induction of host plant defence synthase)

MOA TARGET SITE GROUP NAME CHEMICAL OR COMMON NAME COMMENTS FRAC AND CODE BIOLOGICAL GROUP CODE

benzo- benzo-thiadiazole P 01 thiadiazole acibenzolar-S-methyl Resistance not known. (BTH) P 01 salicylate-related (BTH)

P 02 probenazole benzisothiazole benzisothiazole (also antibacterial and Resistance not known. P 02 salicylate-related antifungal activity)

thiadiazole- thiadiazole- tiadinil

P 03 Resistance not known. P 03 salicylate-related carboxamide carboxamide isotianil

P 04 natural polysaccharides laminarin Resistance not known. polysaccharide compound P 04 elicitors complex mixture, extract from Reynoutria P 05 ethanol extract plant extract sachalinensis (giant Resistance not known. anthraquinone (anthraquinones, P 05 knotweed) elicitors resveratrol) bacterial Bacillus mycoides Bacillus spp. isolate J P 06 microbial cell walls of Resistance not known. fungal P 06 microbial elicitors Saccharomyces cerevisiae Saccharomyces spp. strain LAS117

P: host plant defence induction P:defence plant host Few resistance cases ethyl phosphonates fosetyl-Al reported in few P 07 pathogens. phosphonates P07 phosphonates phosphorous acid and Low risk.

salts Reclassified from U33 in 2018 activates SAR both up- isothiazolylmethyl P 08 P 08 isothiazole dichlobentiazox and downstream of SA. ether salicylate-related Resistance not known.

MOA TARGET SITE GROUP NAME CHEMICAL OR COMMON NAME COMMENTS FRAC AND CODE BIOLOGICAL GROUP CODE Resistance claims described. cyanoacetamide- cyanoacetamide- Low to medium risk. unknown cymoxanil oxime oxime Resistance management 27 required. formerly phosphonates (FRAC code 33), reclassified to P 07 in 2018 tecloftalam unknown phthalamic acids phthalamic acids Resistance not known.

(Bactericide) 34

unknown benzotriazines benzotriazines triazoxide Resistance not known. 35 benzene- benzene- unknown flusulfamide Resistance not known.

sulfonamides sulphonamides 36 fungicides)

unknown pyridazinones pyridazinones diclomezine Resistance not known. 37

formerly methasulfocarb (FRAC code 42), reclassified to M 12 in 2018 Resistance in Sphaerotheca. phenyl- unknown phenyl-acetamide cyflufenamid Resistance management acetamide U 06 required Resistance known in cell membrane Venturia inaequalis. disruption guanidines guanidines dodine Low to medium risk. U 12 (proposed) Resistance management recommended. Resistance in Sphaerotheca and cyano-methylene- Podosphaera xanthii. unknown thiazolidine flutianil thiazolidines Resistance management U 13

U: Unknown mode action of U: required pyrimidinone- pyrimidinone- Resistance not known unknown ferimzone hydrazones hydrazones (previously C5). U 14 Not cross resistant to QoI. complex III: Resistance risk unknown but cytochrome bc1, 4-quinolyl- 4-quinolyl-acetates tebufloquin assumed to be medium. unknown binding acetate U 16

(Unumbers not appearing inthe list derive reclassified from Resistance management site (proposed) required. Resistance not known. Unknown tetrazolyloxime tetrazolyloximes picarbutrazox Not cross resistant to U 17 PA, QoI, CAA. Resistance not known. Unknown glucopyranosyl glucopyranosyl Induction of host plant defense (Inhibition of validamycin antibiotic antibiotics by trehalose proposed U 18 trehalase) (previously H3).

MOA TARGET SITE GROUP NAME CHEMICAL OR COMMON NAME COMMENTS FRAC AND CODE BIOLOGICAL GROUP CODE

mineral oils, organic oils, Resistance not known. Unknown diverse diverse inorganic salts, NC

Not Not material of

specified biological origin

inorganic copper inorganic (electrophiles) (different salts) Also applies to organic copper M 01 complexes inorganic inorganic sulphur M 02 (electrophiles)

siteactivity amobam - ferbam mancozeb maneb dithiocarbamates dithio-carbamates metiram and relatives and relatives propineb M 03 (electrophiles) thiram zinc thiazole zineb ziram

captan phthalimides phthalimides captafol (electrophiles) M 04 M: Chemicals M: with multi folpet chloronitriles (phthalonitriles) chloronitriles generally considered as a low chlorothalonil (unspecified (phthalonitriles) risk group without any signs of M 05 multi-site mechanism) resistance developing to the fungicides. contact sulfamides dichlofluanid sulfamides activity (electrophiles) tolylfluanid M 06

bis-guanidines (membrane guazatine bis-guanidines M 07 disruptors, iminoctadine detergents) triazines (unspecified triazines anilazine M 08 mechanism) quinones quinones (anthraquinones) dithianon (anthraquinones) M 09 (electrophiles)

quinoxalines chinomethionat / quinoxalines (electrophiles) quinomethionate M 10

maleimide maleimide fluoroimide (electrophiles) M 11

thiocarbamate thiocarbamate methasulfocarb reclassified from U42 in 2018 (electrophiles) M 12

MOA TARGET SITE GROUP NAME CHEMICAL OR COMMON NAME COMMENTS FRAC BIOLOGICAL GROUP CODE

multiple effects on extract from the ion membrane cotyledons of transporters; plant extract polypeptide (lectin) Resistance not known. lupine plantlets chelating effects (previously M12). (“BLAD”)

affects fungal phenols, spores and germ sesquiterpenes, extract from tubes, plant extract Resistance not known. triterpenoids, Swinglea glutinosa BM 01 induced plant

coumarins defense extract from Melaleuca alternifolia Plantextracts (tea tree oil) cell membrane Resistance not known. disruption, cell wall, terpene hydrocarbons, (previously F7) plant extract terpene alcohols and induced plant terpene phenols plant oils defense (mixtures): mechanisms eugenol, geraniol, thymol

BM: Biologicals multiple BM: action: of modes with

MOA TARGET SITE GROUP NAME CHEMICAL OR COMMON NAME COMMENTS FRAC BIOLOGICAL GROUP CODE Trichoderma atroviride strain I-1237 strain LU132 strain SC1 strain SKT-1 strain 77B Trichoderma fungal asperellum Trichoderma spp. strain T34 strain kd Trichoderma harzianum

strain T-22 Trichoderma

virens

strain G-41 Gliocladium catenulatum

multiple effects fungal strain J1446 Clonostachys described Clonostachys spp. rosea (examples, not all apply to all strain CR-7 biological groups): Coniothyrium

fungal microbial minitans Coniothyrium spp. competition, strain CON/M/91-08 Resistance not known mycoparasitism, (strains of living Talaromyces BM 02 antibiosis, microbes or fungal flavus membrane extract, Talaromyces spp.

Microbial strain SAY-Y-94-01 disruption by metabolites) Saccharomyces

fungicidal fungal cerevisae lipopeptides, Saccharomyces spp. lytic enzymes, strain LAS02 induced plant Bacillus Bacillus amyloliquefaciens defence amyloliquefaciens reclassified from F6, Code 44 strain QST713 in 2020 strain FZB24 strain MBI600 synonyms for Bacillus BM: Biologicals multiple BM: action: of modes with bacterial strain D747 amyloliquefaciens are Bacillus strain F727 Bacillus spp. subtilis and B. subtilis var. strain AT-332 amyloliquefaciens (previous Bacillus subtilis taxonomic classification).

strain AFS032321 strain Y1336 strain HAI-0404 Pseudomonas bacterial chlororaphis Pseudomonas spp. strain AFS009 Streptomyces griseovirides bacterial strain K61 Streptomyces spp. Streptomyces lydicus strain WYEC108