Development of Electroencephalography Based Brain Controlled Switch and Nerve Conduction Study Simulator Software
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Virginia Commonwealth University VCU Scholars Compass Theses and Dissertations Graduate School 2010 Development of Electroencephalography based Brain Controlled Switch and Nerve Conduction Study Simulator Software Kai Qian Virginia Commonwealth University Follow this and additional works at: https://scholarscompass.vcu.edu/etd Part of the Biomedical Engineering and Bioengineering Commons © The Author Downloaded from https://scholarscompass.vcu.edu/etd/2320 This Thesis is brought to you for free and open access by the Graduate School at VCU Scholars Compass. It has been accepted for inclusion in Theses and Dissertations by an authorized administrator of VCU Scholars Compass. For more information, please contact [email protected]. School of Engineering Virginia Commonwealth University This is to certify that the thesis prepared by Kai Qian entitled “Development of Electroencephalography based Brain Controlled Switch and Nerve Conduction Study Simulator Software” has been approved by his committee as satisfactory completion of the thesis requirement for the degree of Master of Science. Ou Bai, Ph.D., Director of Thesis, School of Engineering Ding-Yu Fei, Ph.D., School of Engineering Scott Vota, D.O., Department of Neurology, VCU Medical Centre Gerald Miller, Ph.D., Chair, Department of Biomedical Engineering, School of Engineering Rosalyn Hobson, Ph.D., Associate Dean of Graduate Studies, School of Engineering Russell Jamison, Ph.D., Dean, School of Engineering F. Douglas Boudinot, Ph.D., Dean of the Graduate School ________________________________________________________________________ Date © Kai Qian, 2010 All Rights Reserved DEVELOPMENT OF AN ELECTROENCEPHALOGRAPHY-BASED BRAIN CONTROLLED SWITCH AND NERVE CONDUCTION STUDY SIMULATOR SOFTWARE A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University. by KAI QIAN B.S., East China University of Science and Technology, People‟s Republic of China, 2005 Director: OU BAI, PH.D. Assistant Professor, Department of Biomedical Engineering Virginia Commonwealth University Richmond, Virginia December, 2010 Acknowledgments I would like to express my gratitude to my adviser Dr. Ou Bai for your continuous support of my study and research. Thank you for your guidance and encouragement that make this thesis possible. I also would like to thank my thesis committee members: Dr. Ding-Yu Fei and Dr. Scott Vota. Thank you for your insightful comments and help in completion of my thesis project. My sincere thanks also goes to Dr. Chike Linton who helped me gather the data and gave me numerous advices on improvements of my research project. I would also like to thank Ms. Cai-Ting Fu and my lab mates Dandan Huang, Deepak Kumbhare, Vaishnavi Karnad, Mason Montgomery, Plamen Nikolov, and William Eggleston for your help in my experiment and study. Lastly, and most importantly, I wish to thank my parents, Enxia Shi and Fenguan Qian. They gave me life, raised me, support me, teach me and love me. To them I dedicate this thesis. ii Table of Contents Page Acknowledgments............................................................................................................... ii List of Abbreviations ......................................................................................................... vi List of Tables ................................................................................................................... viii List of Figures .................................................................................................................... ix Abstract ............................................................................................................................... x Part 1 Development of Electroencephalography based Brain Controlled Switch ...... 1 CHAPTER 1 Introduction................................................................................................... 1 1.1 Background ............................................................................................................... 1 1.2 Objective ................................................................................................................... 4 CHAPTER 2 Methods ........................................................................................................ 8 2.1 Subjects ..................................................................................................................... 8 2.2 Experimental paradigm and behavioral task ............................................................. 8 2.3 Data acquisition and online data processing ........................................................... 12 2.4 Computational algorithm ........................................................................................ 13 2.5 Determine the numbers of moving average epochs ................................................ 14 iii 2.6 Performance evaluation .......................................................................................... 15 CHAPTER 3 Results......................................................................................................... 16 3.1 Time- frequency analysis ........................................................................................ 16 3.2 Determine the numbers of epochs for event-related moving average .................... 18 3.3 Brain-controlled switch performance ..................................................................... 22 CHAPTER 4 Discussion ................................................................................................... 27 4.1 The event-related design of brain-controlled switch .............................................. 27 4.2 Improvement of performance ................................................................................. 30 Part 2 Nerve Conduction Study Simulator Software Design .................................... 32 CHAPTER 5 Introduction................................................................................................. 32 5.1 Neuron action potential ........................................................................................... 32 5.2 Nerve conduction study .......................................................................................... 33 5.3 Motivation ............................................................................................................... 34 5.3.1 Simulation in health care ................................................................................. 34 5.3.2 Simulator for Nerve Conduction Study ........................................................... 36 CHAPTER 6 Nerve Conduction Study Simulator Software Design ................................ 37 6.1 Nerve Conduction Study Simulator ........................................................................ 37 6.2 Design of Nerve Conduction Study Simulator Software ........................................ 38 6.2.1 Waveform parameters ...................................................................................... 39 6.2.2 Standard stimulation point and template waveform. ..................................... 40 iv 6.2.3 Waveform generation model within study region ........................................... 41 6.2.4 Study profile ..................................................................................................... 43 6.2.5 Graphic User Interface Design for Nerve Conduction Simulator .................... 44 6.2.6 Implementation of the Nerve Conduction Study Simulator Software Interface ................................................................................................................................... 46 6.2.7 Nerve conduction velocity test in simulation software .................................... 47 CHAPTER 7 ..................................................................................................................... 52 Literature Cited ................................................................................................................. 54 Appendix A. Simulator Interfaces of 10 Studies .............................................................. 62 Vita .................................................................................................................................... 72 v List of Abbreviations ALS Amyotrophic Lateral Sclerosis ANOVA One-way Analysis of Variance BCI Brain-Computer Interface CNS Central Nervous System DTC Decision Tree Classifier ECoG Electrocorticography EEG Electroencephalography EMG Electromyography EOG Electrooculogram ERD Event-Related Desynchronization ERS Event-Related Synchronization FFT Fast Fourier Transform GA Genetic Algorithm GA-MLD Genetic Algorithm Based Mahalanobis Linear Distance GUI Graphical User Interface LFP Local Field Potentials MLD Mahalanobis Linear Discriminator PSD Power Spectrum Density SLD Surface Laplacian Derivation vi NCS Nerve Conduction Study LAC Lateral Antebrachial Cutaneous MAC Medial Antebrachial Cutaneous vii List of Tables Page Table 1 The online performance of brain-controlled switch with motor imagery during multi-session operation ............................................................................................. 23 Table 2 Amplitude and latency parameters for 9 pathological conditions ....................... 51 viii List of Figures Page Fig. 1. Experimental paradigm............................................................................................ 9 Fig. 2 Time-frequency plots for four subjects from Laplacian