International Journal of Molecular Sciences Review ALLENE OXIDE SYNTHASE and HYDROPEROXIDE LYASE, Two Non-Canonical Cytochrome P450s in Arabidopsis thaliana and Their Different Roles in Plant Defense 1,2 3 4 2, Sachin Rustgi , Armin Springer , ChulHee Kang , Diter von Wettstein y, Christiane Reinbothe 5, Steffen Reinbothe 5,* and Stephan Pollmann 6,* 1 Department of Plant and Environmental Sciences, Pee Dee Research and Education Center, Clemson University, Florence, SC 29506, USA;
[email protected] 2 Department of Crop and Soil Sciences, Washington State University, Pullman, WA 99164, USA;
[email protected] 3 Medizinische Biologie und Elektronenmikroskopisches Zentrum (EMZ), Universitätsmedizin Rostock, 18055 Rostock, Germany;
[email protected] 4 Department of Chemistry, Biomolecular Crystallography Center, Washington State University, Pullman, WA 99164, USA;
[email protected] 5 Biologie Environnementale et Systémique (BEEeSy), Université Grenoble Alpes, BP 53, CEDEX, F-38041 Grenoble, France;
[email protected] 6 Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM)—Instituto Nacional de Investigación y Tecnología Agraria y Alimentación (INIA), Campus de Montegancedo, 28223 Pozuelo de Alarcón, Madrid, Spain * Correspondence: steff
[email protected] (S.R.);
[email protected] (S.P.); Tel.: +33-476635418 (S.R.); +34-910679183 (S.P.) Deceased 13 April 2017. y Received: 29 May 2019; Accepted: 20 June 2019; Published: 23 June 2019 Abstract: The channeling of metabolites is an essential step of metabolic regulation in all living organisms. Multifunctional enzymes with defined domains for metabolite compartmentalization are rare, but in many cases, larger assemblies forming multimeric protein complexes operate in defined metabolic shunts.