DOCSLIB.ORG

TOX-96 Report Series: NTP Toxicity Report Series Report Series Number: 96 Official Citation: National Toxicology Program (NTP)

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
TOX-96 Report Series: NTP Toxicity Report Series Report Series Number: 96 Official Citation: National Toxicology Program (NTP) NTP TECHNICAL REPORT ON THE TOXICITY STUDIES OF PERFLUOROALKYL SULFONATES (PERFLUOROBUTANE SULFONIC ACID, PERFLUOROHEXANE SULFONATE POTASSIUM SALT, AND PERFLUOROOCTANE SULFONIC ACID) ADMINISTERED BY GAVAGE TO SPRAGUE DAWLEY (HSD :S PRAGUE D AWLEY SD) R ATS NTP TOX 96 AUGUST 2019 NTP Technical Report on the Toxicity Studies of Perfluoroalkyl Sulfonates (Perfluorobutane Sulfonic Acid, Perfluorohexane Sulfonate Potassium Salt, and Perfluorooctane Sulfonic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats Toxicity Report 96 August 2019 National Toxicology Program Public Health Service U.S. Department of Health and Human Services ISSN: 2378-8992 Research Triangle Park, North Carolina, USA Perfluoroalkyl Sulfonates, NTP TOX 96 Foreword The National Toxicology Program (NTP) is an interagency program within the Public Health Service (PHS) of the Department of Health and Human Services (HHS) and is headquartered at the National Institute of Environmental Health Sciences of the National Institutes of Health (NIEHS/NIH). Three agencies contribute resources to the program: NIEHS/NIH, the National Institute for Occupational Safety and Health of the Centers for Disease Control and Prevention (NIOSH/CDC), and the National Center for Toxicological Research of the Food and Drug Administration (NCTR/FDA). Established in 1978, the NTP is charged with coordinating toxicological testing activities, strengthening the science base in toxicology, developing and validating improved testing methods, and providing information about potentially toxic substances to health regulatory and research agencies, scientific and medical communities, and the public. The Toxicity Study Report series began in 1991. The studies described in the Toxicity Study Report series are designed and conducted to characterize and evaluate the toxicologic potential of selected substances in laboratory animals (usually two species, rats and mice). Substances selected for NTP toxicity studies are chosen primarily on the basis of human exposure, level of production, and chemical structure. The interpretive conclusions presented in the Toxicity Study Reports are based only on the results of these NTP studies. Extrapolation of these results to other species, including characterization of hazards and risks to humans, requires analyses beyond the intent of these reports. Selection per se is not an indicator of a substance’s toxic potential. The NTP conducts its studies in compliance with its laboratory health and safety guidelines and FDA Good Laboratory Practice Regulations and must meet or exceed all applicable federal, state, and local health and safety regulations. Animal care and use are in accordance with the Public Health Service Policy on Humane Care and Use of Animals. Studies are subjected to retrospective quality assurance audits before being presented for public review. NTP Toxicity Study Reports are indexed in National Center for Biotechnology Information (NCBI) Bookshelf and are available free of charge electronically on the NTP website (http://ntp.niehs.nih.gov). Additional information regarding this study may be requested through Central Data Management (CDM) at [email protected]. Toxicity data are available through NTP’s Chemical Effects in Biological Systems (CEBS) database. ii Perfluoroalkyl Sulfonates, NTP TOX 96 Table of Contents Foreword ......................................................................................................................................... ii Tables ............................................................................................................................................. iv Figures............................................................................................................................................ vi About This Report........................................................................................................................ viii Peer Review .................................................................................................................................. xii Publication Details ....................................................................................................................... xiii Abstract ........................................................................................................................................ xiv Overview ...................................................................................................................................... xix Introduction ......................................................................................................................................1 Chemical and Physical Properties ...............................................................................................1 Production, Use, and Human Exposure ......................................................................................1 Regulatory Status ........................................................................................................................2 Absorption, Distribution, Metabolism, Excretion, and Toxicokinetics ......................................3 Toxicity .......................................................................................................................................4 Experimental Animals .........................................................................................................4 Humans ................................................................................................................................5 Carcinogenicity ...........................................................................................................................5 Experimental Animals .........................................................................................................5 Humans ................................................................................................................................5 Genetic Toxicity ..........................................................................................................................5 Study Rationale ...........................................................................................................................6 Materials and Methods .....................................................................................................................7 Procurement and Characterization ..............................................................................................7 Perfluoroalkyl Sulfonates.....................................................................................................7 Wyeth-14,643.......................................................................................................................8 Tween® 80 ............................................................................................................................8 Preparation and Analysis of Dose Formulations .........................................................................8 Animal Source .............................................................................................................................9 Animal Welfare ...........................................................................................................................9 28-day Studies ...........................................................................................................................10 Statistical Methods ....................................................................................................................16 Calculation and Analysis of Lesion Incidences .................................................................16 Analysis of Continuous Variables .....................................................................................16 Quality Assurance Methods ......................................................................................................16 Genetic Toxicology ...................................................................................................................17 Bacterial Mutagenicity Test Protocol ................................................................................17 Rat Peripheral Blood Micronucleus Test Protocol ............................................................17 Evaluation Protocol ............................................................................................................18 Results ............................................................................................................................................19 28-day Studies ...........................................................................................................................19 iii Perfluoroalkyl Sulfonates, NTP TOX 96 Perfluorobutane Sulfonic Acid (PFBS) .............................................................................19 Perfluorohexane Sulfonate Potassium Salt (PFHxSK) ......................................................34 Perfluorooctane Sulfonic Acid (PFOS) .............................................................................43 Wyeth-14,643.....................................................................................................................55 Histopathologic Descriptions .............................................................................................62 Genetic Toxicology ...................................................................................................................64 Discussion
Load more

Recommended publications
  • Chemical Characterization and Thermal Stressing Studies of Perfluorohexane Fluids for Space-Based Applications
    Chemical Characterization and Thermal Stressing Studies of Perfluorohexane Fluids for Space-Based Applications William A. Arnold, Ph.D.1 ZIN Technologies, Inc., Brook Park, Ohio, 44142, USA Thomas G. Hartman, Ph.D.2 CAFT, Cook College, Rutgers the Sate University of New Jersey, New Brunswick, NJ, 08901 USA John McQuillen,3 NASA Glenn Research Center, Cleveland, Ohio, 44135, USA Perfluorohexane (PFH), C6F14, is a perfluorocarbon fluid. Several PFH fluids with different isomer concentrations were evaluated for use in an upcoming NASA space experiment. Samples tested included two commercially obtained high-purity n-perfluorohexane (n-PFH) fluids and a technical grade mixture of C6F14 branched and linear isomers (FC-72). These fluids were evaluated for exact chemical composition, impurity purity and high temperature degradation behavior (pyrolysis). Our investigation involved simulated thermal stressing studies of PFH fluids under conditions likely to occur in the event of an atmospheric breach within the International Space Station (ISS) and subsequent exposure of the vapors to the high temperature and catalyst present in its Trace Contaminant Control Subsystem (TCCS). Exposure to temperatures in the temperature range of 200-450°C in an inert or oxidizing atmosphere, with and without the presence of catalyst was investigated. The most aggressive conditions studied were exposure of PFH vapors to 450°C in air and in the presence of TCCS (palladium) catalyst. Gas chromatography-mass spectrometry (GC-MS) and gas chromatography (GC) analyses were conducted on the perfluorohexane samples before and after pyrolysis. The FC-72 and n-PFH samples showed no significant degradation following pyrolysis even under the most aggressive study conditions.
    [Show full text]
  • Analytical Standards for Human Exposure Analysis
    ENVIRONMENTAL STANDARDS Cambridge Isotope Laboratories, Inc. isotope.com Analytical Standards for Human Exposure Analysis Human Personal Care Industrial Products Pollution Dermal Inhalation Ingestion Food Tobacco Products Drinking Water Pharmaceuticals Cambridge Isotope Laboratories, Inc. North America: 1.800.322.1174 [email protected] | International: +1.978.749.8000 [email protected] | fax: 1.978.749.2768 | isotope.com Cambridge Isotope Laboratories, Inc. | Analytical Standards for Human Exposure Analysis Analytical Standards for Human Exposure Analysis Exposomics is the study of the exposome and is a field that has been gaining attention as researchers focus not only on identifying contaminants present in the environment, but their effects on humans. The exposome encompasses an individual’s lifetime exposure to internal and external stresses, including environmental, dietary, and metabolic factors, to name a few. Cambridge Isotope Laboratories, Inc. (CIL) has and continues to produce standards that are used in many leading biomonitoring research projects, such as the US Centers for Disease Control and Prevention (CDC) “National Health and Nutrition Examination Survey (NHANES)” and the Japan National Institute for Environmental Studies (NIES) “Japan Environment and Children’s Study (JECS).” The CDC’s NHANES program is focused on assessing the health and nutritional status of both children and adults in the United States. There are several studies involved in this program, which is notable in that both interviews and physical examinations are factored in when compiling data. The first NHANES study was conducted from 1971-1975 and subsequent studies are continuing to this day. Additional information about the NHANES program can be found at www.cdc.gov/nchs/nhanes/index.htm.
    [Show full text]
  • Priority Pollutant, Endocrine Disruptor, and Chemical Contaminant Standards Solutions for a Greener World Introduction
    Priority Pollutant, Endocrine Disruptor, and Chemical Contaminant Standards Solutions for a Greener World Introduction Priority Pollutant, Endocrine Disruptor, and Chemical Contaminant Standards isotope.com Pharmaceutical and Personal Care Product Halogenated and Substituted Benzene Standards and Phenol Standards Concern about environmental and human exposure to Many industrial and consumer products are composed of pharmaceuticals and personal care products (PPCPs) has grown chemicals that contain halogenated or substituted benzene significantly. This classification encompasses a broad range of or phenol functional groups. Resistant to decomposition and chemicals, ranging from antibiotics to hormones to pesticides. metabolism, these chemicals may persist even after the parent One common theme among these groups is the need for molecule has undergone partial decomposition, or they may high-quality isotopically labeled standards to strengthen the exist as a product or an industrial byproduct. The increased analysis of PPCPs in difficult matrices such as sewage sludge use of brominated compounds is expected to lead to more and wastewater. CIL, with guidance from leading laboratories brominated benzenes and phenols in the environment, and around the world, works diligently to produce representative the continued presence of chlorinated compounds ensures standards for the analysis of PPCPs. that chlorinated benzenes and phenols will be found in the environment for years to come. Food and Drinking Water Analysis Standards Bisphenol Standards Increased attention to possible contamination of food and Bisphenol A (BPA) is a synthetic compound that has long been water has caused analysts to broaden the scope of trace food used in the production of polycarbonate plastics and epoxy and water testing by IDMS.
    [Show full text]
  • Human Health Toxicity Values for Perfluorobutane Sulfonic Acid (CASRN 375-73-5) and Related Compound Potassium Perfluorobutane Sulfonate (CASRN 29420 49 3)
    EPA-823-R-18-307 Public Comment Draft Human Health Toxicity Values for Perfluorobutane Sulfonic Acid (CASRN 375-73-5) and Related Compound Potassium Perfluorobutane Sulfonate (CASRN 29420-49-3) This document is a Public Comment draft. It has not been formally released by the U.S. Environmental Protection Agency and should not at this stage be construed to represent Agency policy. This information is distributed solely for the purpose of public review. This document is a draft for review purposes only and does not constitute Agency policy. DRAFT FOR PUBLIC COMMENT – DO NOT CITE OR QUOTE NOVEMBER 2018 Human Health Toxicity Values for Perfluorobutane Sulfonic Acid (CASRN 375-73-5) and Related Compound Potassium Perfluorobutane Sulfonate (CASRN 29420 49 3) Prepared by: U.S. Environmental Protection Agency Office of Research and Development (8101R) National Center for Environmental Assessment Washington, DC 20460 EPA Document Number: 823-R-18-307 NOVEMBER 2018 This document is a draft for review purposes only and does not constitute Agency policy. DRAFT FOR PUBLIC COMMENT – DO NOT CITE OR QUOTE NOVEMBER 2018 Disclaimer This document is a public comment draft for review purposes only. This information is distributed solely for the purpose of public comment. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. i This document is a draft for review purposes only and does not constitute Agency policy. DRAFT FOR PUBLIC COMMENT – DO NOT CITE OR QUOTE NOVEMBER 2018 Authors, Contributors, and Reviewers CHEMICAL MANAGERS Jason C.
    [Show full text]
  • United Nations Sc
    UNITED NATIONS SC UNEP/POPS/POPRC.12/INF/16 Distr.: General 2 August 2016 English only Stockholm Convention on Persistent Organic Pollutants Persistent Organic Pollutants Review Committee Twelfth meeting Rome, 19–23 September 2015 Item 4 (d) of the provisional agenda Technical work: consolidated guidance on alternatives to perfluorooctane sulfonic acid and its related chemicals Comments and responses relating to the draft consolidated guidance on alternatives to perfluorooctane sulfonic acid and its related chemicals Note by the Secretariat As referred to in the note by the Secretariat on guidance on alternatives to perfluorooctane sulfonic acid and its related chemicals (UNEP/POPS/POPRC.12/7), the annex to the present note contains a table listing the comments and responses relating to the draft guidance. The present note, including its annex, has not been formally edited. UNEP/POPS/POPRC.12/1. 030816 UNEP/POPS/POPRC.12/INF/16 Annex Comments and responses relating to the draft consolidated guidance on alternatives to perfluorooctane sulfonic acid and its related chemicals Minor grammatical or spelling changes have been made without acknowledgment. Only substantial comments are listed. Yellow highlight indicates addition of text while green highlight indicates deletion. Source of Page Para Comments on the second draft Response Comment Austria 7 2 This statement is better placed in Chapter VII Rejected. accompanied with a justification for those “critical applications”. For clarification “where it is not currently possible without the use of PFOS” is added Austria 15 47 According to May be commercialized is revised to http://poppub.bcrc.cn/col/1413428117937/index.html “are commercialized” F-53 and F-53B have a long history of usage and have been commercialized before PFOS related Reference substances were used (cf.
    [Show full text]
  • Alkane Coiling in Perfluoroalkane Solutions
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Repositório Científico da Universidade de Évora Article Cite This: Langmuir 2017, 33, 11429-11435 pubs.acs.org/Langmuir Alkane Coiling in Perfluoroalkane Solutions: A New Primitive Solvophobic Effect † ‡ § † ∥ ‡ Pedro Morgado, Ana Rosa Garcia, , Luís F. G. Martins, , Laura M. Ilharco,*, † and Eduardo J. M. Filipe*, † ‡ Centro de Química Estrutural, Instituto Superior Tecnicó and Centro de Química-Física Molecular and Institute of Nanoscience and Nanotechnology, Instituto Superior Tecnico,́ Universidade de Lisboa, 1049-001 Lisboa, Portugal § Departamento de Química e Farmacia,́ FCT, Universidade do Algarve, 8000 Faro, Portugal ∥ Centro de Química de Évora, Escola de Cienciaŝ e Tecnologia, Universidade de Évora, 7000-671 Évora, Portugal *S Supporting Information ABSTRACT: In this work, we demonstrate that n-alkanes coil when mixed with perfluoroalkanes, changing their conformational equilibria to more globular states, with a higher number of gauche conformations. The new coiling effect is here observed in fluids governed exclusively by dispersion interactions, contrary to other examples in which hydrogen bonding and polarity play important roles. FTIR spectra of liquid mixtures of n-hexane and perfluorohexane unambiguously reveal that the population of n-hexane molecules in all-trans conformation reduces from 32% in the pure n-alkane to practically zero. The spectra of perfluorohexane remain unchanged, suggesting nanosegregation of the hydrogenated and fluorinated chains. Molecular dynamics simulations support this analysis. The new solvophobic effect is prone to have a major impact on the structure, organization, and therefore thermodynamic properties and phase equilibria of fluids involving mixed hydrogenated and fluorinated chains.
    [Show full text]
  • Recommendation on Perfluorinated Compound Treatment Options for Drinking Water
    Recommendation on Perfluorinated Compound Treatment Options for Drinking Water New Jersey Drinking Water Quality Institute Treatment Subcommittee June 2015 Laura Cummings, P.E., Chair Anthony Matarazzo Norman Nelson, P.E. Fred Sickels Carol T. Storms Background At the request of the Commissioner of the New Jersey Department of Environmental Protection the Drinking Water Quality Institute (DWQI) is working to develop recommended Maximum Contaminant Levels (MCL) for three long-chain perfluorinated compounds (PFC): Perfluorononanoic acid (PFNA), Perfluorooctanoic acid (PFOA) and Perfluorooctanesulfonic acid (PFOS). The Treatment Subcommittee of the Drinking Water Quality Institute is responsible for identifying available treatment technologies or methods for removal of hazardous contaminants from drinking water. The subcommittee has met several times over the last year beginning in July 2014 to discuss and investigate best available treatment options for the long-chain (8 – 9 carbon) PFCs identified above. The subcommittee decided to research and report on treatment options for all three compounds, as the treatment options are not expected to differ from compound to compound due to their similar properties (e.g. persistence, water solubility, similar structure, strong carbon-fluorine bonds, and high polarity). This approach contrasts with the other two subcommittees which will address the three compounds separately. The subcommittee has gathered and reviewed data from several sources in order to identify widely-accepted and well-performing strategies for removal of long-chain PFCs, including use of alternate sources. This report is intended to present the subcommittee’s findings. At this time, there are no Federal drinking water standards for PFNA, PFOA or PFOS; however in 2009 the United State Environmental Protection Agency (USEPA, 2009) established a Provisional Health Advisory (PHA) level of 0.4 µg/L for PFOA and 0.2 µg/L PHA for PFOS for short-term exposure.
    [Show full text]
  • PERFLUOROHEXANE SULFONATE (Pfhxs)— SOCIO-ECONOMIC IMPACT, EXPOSURE, and the PRECAUTIONARY PRINCIPLE
    PERFLUOROHEXANE SULFONATE (PFHxS)— SOCIO-ECONOMIC IMPACT, EXPOSURE, AND THE PRECAUTIONARY PRINCIPLE IPEN Expert Panel Rome October 2019 PERFLUOROHEXANE SULFONATE (PFHxS)—SOCIO-ECONOMIC IMPACT, EXPOSURE, AND THE PRECAUTIONARY PRINCIPLE September 2019 Bluteau, T. a, Cornelsen, M. b, Holmes, N.J.C. c, Klein, R.A. d, McDowall, J.G.e, Shaefer, T.H. f, Tisbury, M. g, Whitehead, K. h. a Leia Laboratories, France b Cornelsen Umwelttechnologie GmbH, Essen, Germany c Department of of Science and Environment, Queensland Government, Australia d Cambridge, United Kingdom, and Christian Regenhard Center for Emergency Response Studies, John Jay College of Criminal Justice, City University New York (CUNY), New York USA e 3FFF Ltd, Corby, United Kingdom f Sydney, Australia g United Firefighters Union and Melbourne Metropolitan Fire Brigade (MFB), Australia h Unity Fire & Safety, Oman representing the IPEN Panel of Independent Experts White Paper prepared for IPEN by members of the IPEN Expert Panel and associates for the meeting of the Stock- holm Convention POPs Review Committee (POPRC-15), 1-4 October 2019, Rome, Italy © 2019 IPEN and Authors Listed as IPEN Expert Panel Members Cite this publication as: IPEN 2019. White Paper for the Stockholm Convention Persistent Organic Pollutants Review Committee (POPRC-15). Perfluorohexane Sulfonate (PFHxS)—Socio-Economic Impact, Exposure, and the Precautionary Principle. Corresponding authors: R. A. Klein <[email protected]>, Nigel Holmes <[email protected]> For your reference, the previously presented
    [Show full text]
  • UNITED NATIONS Stockholm Convention on Persistent Organic Pollutants Technical Paper on the Identification and Assessment Of
    UNITED NATIONS SC UNEP/POPS/POPRC.8/INF/17 Distr.: General 15 August 2012 English only Stockholm Convention on Persistent Organic Pollutants Persistent Organic Pollutants Review Committee Eighth meeting Geneva, 15–19 October 2012 Item 5 (g) of the provisional agenda* Technical work: assessment of alternatives to perfluorooctane sulfonic acid in open applications Technical paper on the identification and assessment of alternatives to the use of perfluorooctane sulfonic acid in open applications Note by the Secretariat 1. In paragraph 6 of decision SC-5/5, the Conference of the Parties to the Stockholm Convention requested the Secretariat, subject to the availability of resources, to commission a technical paper on the identification and assessment of alternatives to the use of perfluorooctane sulfonic acid in open applications for consideration by the Persistent Organic Pollutants Review Committee at its eighth meeting. 2. That technical paper has been prepared, with financial support provided by the Government of Norway, on the basis of the terms of reference and an outline developed by the Committee at its seventh meeting. It is set out in the annex to the present note, where it is presented without formal editing. * UNEP/POPS/POPRC.8/1. K1282361 110912 UNEP/POPS/POPRC.8/INF/17 Annex Technical paper on the identification and assessment of alternatives to the use of perfluorooctane sulfonic acid in open applications 2 UNEP/POPS/POPRC.8/INF/17 Table of contents Executive summary.........................................................................................................................................................
    [Show full text]
  • Inventory of US Greenhouse Gas Emissions and Sinks: 1990-2015
    ANNEX 6 Additional Information 6.1. Global Warming Potential Values Global Warming Potential (GWP) is intended as a quantified measure of the globally averaged relative radiative forcing impacts of a particular greenhouse gas. It is defined as the cumulative radiative forcing–both direct and indirect effectsintegrated over a specific period of time from the emission of a unit mass of gas relative to some reference gas (IPCC 2007). Carbon dioxide (CO2) was chosen as this reference gas. Direct effects occur when the gas itself is a greenhouse gas. Indirect radiative forcing occurs when chemical transformations involving the original gas produce a gas or gases that are greenhouse gases, or when a gas influences other radiatively important processes such as the atmospheric lifetimes of other gases. The relationship between kilotons (kt) of a gas and million metric tons of CO2 equivalents (MMT CO2 Eq.) can be expressed as follows: MMT MMT CO2 Eq. kt of gas GWP 1,000 kt where, MMT CO2 Eq. = Million metric tons of CO2 equivalent kt = kilotons (equivalent to a thousand metric tons) GWP = Global warming potential MMT = Million metric tons GWP values allow policy makers to compare the impacts of emissions and reductions of different gases. According to the IPCC, GWP values typically have an uncertainty of 35 percent, though some GWP values have larger uncertainty than others, especially those in which lifetimes have not yet been ascertained. In the following decision, the parties to the UNFCCC have agreed to use consistent GWP values from the IPCC Fourth Assessment Report (AR4), based upon a 100 year time horizon, although other time horizon values are available (see Table A-263).
    [Show full text]
  • Investigation of Levels of Perfluorinated Compounds in New Jersey Fish, Surface Water, and Sediment
    Investigation of Levels of Perfluorinated Compounds in New Jersey Fish, Surface Water, and Sediment New Jersey Department of Environmental Protection Division of Science, Research, and Environmental Health SR15-010 June 18, 2018 Updated April 9, 2019 Lead Investigators: Sandra M. Goodrow, Ph.D., Bruce Ruppel, Lee Lippincott, Ph.D., Gloria B. Post, Ph.D., D.A.B.T. 1 Executive Summary Per- and polyfluorinated substances (PFAS) are used in the manufacture of useful products that impart stain resistance, water resistance, heat resistance and other desirable properties. PFAS are also used in various Aqueous Film Forming Foams (AFFF) that are used in fire-fighting. These substances are in wide use today, found at industrial sites that use or manufacture them and at military bases, airports and other areas known for fire-fighting activities. A subset of PFAS, perfluorinated compounds (PFCs), have fully fluorinated carbon chains as their backbone, and their extremely strong carbon-fluorine bonds makes them very resistant to degradation. When released to the environment, PFCs persist indefinitely and can travel distances from their source in surface water, groundwater, or in the atmosphere. PFAS are considered “emerging contaminants” because additional information on their presence and toxicity to ecosystems and humans continues to become available. The Division of Science, Research and Environmental Health (DSREH) performed an initial assessment of 13 PFAS, all of which are perfluorinated compounds (PFCs), at 11 waterways across the state. Fourteen surface water and sediment samples and 94 fish tissue samples were collected at sites along these waterways. The sites were selected based on their proximity to potential sources of PFAS and their likelihood of being used for recreational and fishing purposes.
    [Show full text]
  • Chemicals Americas
    Chemicals in the Americas November 30, 2017 The Houston Club, Houston TX www.bdlaw.com/2017ChemicalsConference Global Influences on National Chemical Laws Russ LaMotte, Managing Principal, Beveridge & Diamond www.bdlaw.com/2017ChemicalsConference Goals • Identify key global KEY TAKEAWAYS drivers of chemicals Your takeaways policy here • Flag opportunities to track and influence www.bdlaw.com/2017ChemicalsConference 3 Agenda 1. Global Outlook 2. European Union & REACH: Global Impacts KEY TAKEAWAYS 3. Multilateral Treaties Your takeaways here − Stockholm Convention on Persistent Organic Pollutants − Rotterdam Convention on Prior Informed Consent 4. Other Pressure Points − UN Environment Assembly (UNEA) − Strategic Approach to International Chemicals Management (SAICM) www.bdlaw.com/2017ChemicalsConference 4 New Section/Subsection Divider OptionGlobal 2 – Picture Outlook Background Global Chemical Policy Initiatives International Orgs Key National Regimes OECD European Union WHO United States (TSCA) FAO Canada APEC Japan UNEA Australia China SAICM CA/WA/OR/MN UNECE (GHS) Multilateral Treaties NGOs IPEN Stockholm (PBTs) Greenpeace (“detox”) Rotterdam PIC SIN (hazardous chemicals trade) Retailers/Purchasers Basel (hazardous Walmart waste) Target Montreal Protocol WERCs (ODS and HFCs) Green procurement Minimata Mercury Market deselection Restricted Chemicals Lists Global Chemical Policy Initiatives International Orgs Key National Regimes OECD European Union WHO United States (TSCA) FAO Canada APEC Japan UNEA Australia China SAICM CA/WA/OR/MN
    [Show full text]