bioRxiv preprint doi: https://doi.org/10.1101/2020.09.06.274720; this version posted September 7, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC 4.0 International license. 1 TITLE 2 NLRC5 regulates expression of MHC-I and provides a target for anti-tumor immunity in 3 transmissible cancers 4 RUNNING TITLE 5 NLRC5 upregulates MHC-I on transmissible tumors 6 AUTHORS 7 Chrissie E. B. Ong1*, Amanda L. Patchett1, Jocelyn M. Darby1, Jinying Chen1,2, Guei-Sheung 8 Liu1,3, A. Bruce Lyons4, Gregory M. Woods1, Andrew S. Flies1* 9 AFFILIATIONS 10 1Menzies Institute for Medical Research, College of Health and Medicine, University of 11 Tasmania, Hobart, TAS, Australia 12 2Department of Ophthalmology, the First Affiliated Hospital of Jinan University, Guangzhou, 13 China 14 3Ophthalmology, Department of Surgery, University of Melbourne, East Melbourne, 15 Australia 16 4Tasmanian School of Medicine, College of Health and Medicine, University of Tasmania, 17 Hobart, TAS, Australia 18 CORRESPONDING AUTHORS CONTACT INFORMATION 19 Andrew S. Flies, PhD 20 Menzies Institute for Medical Research, College of Health and Medicine 21 University of Tasmania 22 Private Bag 23, Hobart TAS 7000 23 phone: +61 3 6226 4614; email:
[email protected] 24 Chrissie E. B. Ong, PhD candidate 25 Menzies Institute for Medical Research, College of Health and Medicine 26 University of Tasmania 27 Private Bag 23, Hobart TAS 7000 28 email:
[email protected] 29 KEYWORDS 30 transmissible cancer, devil facial tumor, allograft, MHC-I, NLRC5, contagious cancer, 31 immune evasion, wild immunology 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.09.06.274720; this version posted September 7, 2020.