Dissociations Between Microstructural and Functional Hierarchies Within Regions of Transmodal Cortex
bioRxiv preprint doi: https://doi.org/10.1101/488700; this version posted December 7, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. DISSOCIATIONS BETWEEN MICROSTRUCTURAL AND FUNCTIONAL HIERARCHIES WITHIN REGIONS OF TRANSMODAL CORTEX PAQUOLA C1, VOS DE WAEL R1, WAGSTYL K2, BETHLEHEM RAI3, HONG SJ1, SEIDLITZ J4,5, BULLMORE ET5, EVANS AC1,2, MISIC B1, MARGULIES DS6, SMALLWOOD J7, BERNHARDT BC1* 1 McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada; 2 McGill Centre for Integrative Neuroscience, McGill University, Montreal, QC, Canada; 3 Autism Research Centre, Department of Psychiatry, University of Cambridge, England, United Kingdom; 4 Developmental Neurogenomics Unit, National Institute of Mental Health, Bethesda, MD 20892, USA; 5 Brain Mapping Unit, University of Cambridge, Department of Psychiatry, Cambridge CB2 0SZ, UK; 6 Frontlab, Institut du Cerveau et de la Moelle épinière, UPMC UMRS 1127, Inserm U 1127, CNRS UMR 7225, Paris, France; 7 York Neuroimaging Center, University of York, UK SUMMARY While the role of cortical microstructure in organising neural function is well established, it remains unclear how structural constraints can give rise to more flexible elements of cognition. While non- human primate research has demonstrated a close structure-function correspondence, the relationship between microstructure and function remains poorly understood in humans, in part because of the reliance on post mortem analyses which cannot be directly related to functional data. To overcome this barrier, we developed a novel approach to model the similarity of microstructural profiles sampled in the direction of cortical columns.
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