Prevention and Control of Malaria in Pregnancy in the African Region

Total Page:16

File Type:pdf, Size:1020Kb

Prevention and Control of Malaria in Pregnancy in the African Region P R E V E N T I O N A N D C O N T R O L O F M A L A R I A I N PREGNANC Y I N THE A FRIC AN R EGION A Program Implementation Guide P R E V E N T I O N A N D C O N T R O L O F M A L A R I A I N PREGNANC Y I N THE A FRIC AN R EGION A Program Implementation Guide For information: Jhpiego 1615 Thames Street Baltimore, MD 21231-3492, USA Tel: 410.537.1800 www.jhpiego.org Editor: Ann Blouse Graphic Design: Trudy Conley The ACCESS Program is the U.S. Agency for International Developments global program to improve maternal and newborn health. The ACCESS Program works to expand coverage, access and use of key maternal and newborn health services across a continuum of care from the household to the hospitalwith the aim of making quality health services accessible as close to the home as possible. Jhpiego implements the program in partnership with Save the Children, the Futures Group, the Academy for Educational Development, the American College of Nurse- Midwives and IMA World Health. www.accesstohealth.org Jhpiego is an international, non-profit health organization affiliated with The Johns Hopkins University. For nearly 40 years, Jhpiego has empowered front-line health workers by designing and implementing effective, low-cost, hands-on solutions to strengthen the delivery of health care services for women and their families. By putting evidence-based health innovations into everyday practice, Jhpiego works to break down barriers to high-quality health care for the worlds most vulnerable populations. March 2008 TABLE OF CONTENTS TABLE OF CONTENTS ............................................................................................................ iii ACKNOWLEDGMENTS .............................................................................................................v ABBREVIATIONS AND ACRONYMS................................................................................... vii SECTION 1: INTRODUCTION ..................................................................................................1 Purpose and Audience..........................................................................................................1 Overview: The World Health Organization Strategy for the Prevention and Control of Malaria during Pregnancy in the African Region................................................................2 Integration, Collaboration and Partnerships ........................................................................5 Current Status of Country MIP Policies and Programs .....................................................11 References for Section 1 ....................................................................................................17 Resources for Section 1 .....................................................................................................18 SECTION 2: ESSENTIAL COMPONENTS FOR IMPLEMENTING PROGRAMS.........19 Overview............................................................................................................................19 SECTION 2-1: TRANSLATE MIP POLICY INTO SERVICE DELIVERY GUIDELINES ..................................................................................................................20 Key Issues ..........................................................................................................................24 Country Example: Zambia.................................................................................................25 Resources for Section 2-1 ..................................................................................................28 SECTION 2-2: COMMODITIES...............................................................................................29 2-2.1: Ensure Appropriate Pharmaceutical Management for Preventing and Treating Malaria in Pregnancy ......................................................................................29 Key Issues ..........................................................................................................................36 Country Example: Ghana...................................................................................................37 Resources for Section 2-2.1 ...............................................................................................40 2-2.2: Ensure Distribution of Insecticide-Treated Nets for Prevention and Control of Malaria in Pregnancy..................................................................................................41 Education and Counseling .................................................................................................42 Forecasting, Procurement and Distribution .......................................................................43 Key Issues ..........................................................................................................................46 Country Example: Malawi ................................................................................................48 Resources for Section 2-2.2 ...............................................................................................51 SECTION 2-3: USE PERFORMANCE STANDARDS TO HELP ASSURE HIGH- QUALITY MIP SERVICES .......................................................................................................52 Key Issues ..........................................................................................................................56 Country Example: Madagascar..........................................................................................56 Resources for Section 2-3 ..................................................................................................60 Malaria in Pregnancy Program Implementation Guide iii SECTION 2-4: BUILD HUMAN CAPACITY THROUGH TRAINING TO ENSURE IMPLEMENTATION OF MIP GUIDELINES........................................................................61 Pre-Service Education........................................................................................................61 In-Service Training ............................................................................................................62 Key Issues ..........................................................................................................................65 Country Example: Kenya...................................................................................................66 Resources for Section 2-4 ..................................................................................................68 SECTION 2-5: MOBILIZE COMMUNITIES TO TAKE ACTION TO PREVENT MALARIA IN PREGNANCY....................................................................................................70 Community Action Cycle for Community Mobilization...................................................71 Key Issues ..........................................................................................................................77 Country Example: Burkina Faso........................................................................................78 References for Section 2-5.................................................................................................80 Resources for Section 2-5 ..................................................................................................81 SECTION 2-6: MONITOR AND EVALUATE PROGRAMS FOR PREVENTION AND CONTROL OF MALARIA IN PREGNANCY ........................................................................82 Developing a Monitoring and Evaluation Plan for MIP Programs....................................82 Selection of Indicators .......................................................................................................84 Output Indicators ...............................................................................................................85 Data Sources ......................................................................................................................86 Key Issues ..........................................................................................................................88 Country Examples: Uganda And Kenya ...........................................................................89 Overview of the Pilot Test .................................................................................................90 Summary of Findings.........................................................................................................91 Lessons Learned.................................................................................................................92 Reference for Section 2-6 ..................................................................................................93 Resources for Section 2-6 ..................................................................................................93 SECTION 3: PRACTICAL SOLUTIONS TO FREQUENTLY SEEN PROBLEMS..........95 Women Do Not Come Early in Their Pregnancies for ANC.............................................95 Women Are Not Given Antimalarial Drugs Recommended per National Guidelines or Do Not Use Them if They Are Available..........................................................................96 Women Are Unable to Obtain ITNs or Do Not Use Them if They Are Available. ..........97 Reference for Section 3......................................................................................................98 SECTION 4: FINANCING CONSIDERATIONS....................................................................99
Recommended publications
  • Annual Meeting
    Volume 97 | Number 5 Volume VOLUME 97 NOVEMBER 2017 NUMBER 5 SUPPLEMENT SIXTY-SIXTH ANNUAL MEETING November 5–9, 2017 The Baltimore Convention Center | Baltimore, Maryland USA The American Journal of Tropical Medicine and Hygiene The American Journal of Tropical astmh.org ajtmh.org #TropMed17 Supplement to The American Journal of Tropical Medicine and Hygiene ASTMH FP Cover 17.indd 1-3 10/11/17 1:48 PM Welcome to TropMed17, our yearly assembly for stimulating research, clinical advances, special lectures, guests and bonus events. Our keynote speaker this year is Dr. Paul Farmer, Co-founder and Chief Strategist of Partners In Health (PIH). In addition, Dr. Anthony Fauci, Director of the National Institute of Allergy and Infectious Diseases, will deliver a plenary session Thursday, November 9. Other highlighted speakers include Dr. Scott O’Neill, who will deliver the Fred L. Soper Lecture; Dr. Claudio F. Lanata, the Vincenzo Marcolongo Memorial Lecture; and Dr. Jane Cardosa, the Commemorative Fund Lecture. We are pleased to announce that this year’s offerings extend beyond communicating top-rated science to direct service to the global community and a number of novel events: • Get a Shot. Give a Shot.® Through Walgreens’ Get a Shot. Give a Shot.® campaign, you can not only receive your free flu shot, but also provide a lifesaving vaccine to a child in need via the UN Foundation’s Shot@Life campaign. • Under the Net. Walk in the shoes of a young girl living in a refugee camp through the virtual reality experience presented by UN Foundation’s Nothing But Nets campaign.
    [Show full text]
  • Maternal Mortality and HIV: an Overview
    Maternal Mortality and HIV: An Overview Contextual factors such as local policies and cultural norms, as well as socioeconomic factors, play a role in women’s ability to access care and receive appropriate treatment during pregnancy, childbirth, and postpartum.1 This is true for all women, and particularly so for the 17 million women living with HIV globally, the vast majority of whom live in sub-Saharan Africa (SSA) and are of reproductive age.2 In 2013, HIV was responsible for 1.5% of all maternal Adult HIV prevalence rates, 2012 data from Global Report: UNAIDS Report on the Global AIDS Epidemic 2013. deaths in SSA and 0.4% worldwide.3 Pregnant women living with HIV have between a two to 10 times increased risk of death than uninfected pregnant women.4,5,6,7,8 While maternal deaths have decreased overall in the past decade, countries with high HIV burdens have had slower declines compared to countries less affected by the HIV pandemic. For example, South Africa—an upper middle-income country with an HIV infection rate among pregnant women aged 15-49 years of 29.5%9—experienced a decrease of only 0.4% in its maternal mortality ratio (MMR) between 1990 and Data on maternal mortality ratio (per 100,000 live births) from World 2013, despite a global MMR decrease of 45% in the Health Organization 2012. same timeframe10. CAUSES OF MATERNAL MORBIDITY AND MORTALITY AMONG WOMEN LIVING WITH HIV The World Health Organization (WHO) defines maternal death as “the death of a woman during pregnancy or within 42 days of termination of pregnancy irrespective
    [Show full text]
  • Introduction to the Maternal and Newborn Quality of Care Surveys
    INTRODUCTION TO THE MATERNAL AND NEWBORN QUALITY OF CARE SURVEYS Introduction To The Quality of Care Surveys i The Maternal and Child Health Integrated Program (MCHIP) is the United States Agency for International Development’s Bureau for Global Health flagship maternal, neonatal and child health program. MCHIP supports programming in maternal, newborn and child health, immunization, family planning, malaria and HIV/AIDS, and strongly encourages opportunities for integration. Cross-cutting technical areas include water, sanitation, hygiene, urban health and health systems strengthening. This study was made possible by the generous support of the American people through the United States Agency for International Development (USAID), under the terms of the Leader with Associates Cooperative Agreement GHS-A-00-08-00002-00. The contents are the responsibility of the Maternal and Child Health Integrated Program (MCHIP) and do not necessarily reflect the views of USAID or the United States Government. Published by: Jhpiego Brown’s Wharf 1615 Thames Street Baltimore, Maryland 21231-3492, USA January 2013 Introduction To The Quality of Care Surveys ii 1. BACKGROUND Improving the quality of obstetric care in facilities has recently been identified as a neglected and essential approach to reducing maternal deaths and enabling developing countries to achieve Millennium Development Goal (MDG) 4 and 5.1 Postpartum hemorrhage is the most frequent cause of maternal deaths globally and in developing countries, accounting for 25% of maternal deaths. Next are hypertensive disorders in pregnancy (PE/E) at 15%, sepsis (8%) and obstructed labor (7%).2 Effective interventions exist for screening, preventing and treating obstetric and newborn complications, and they can be readily provided by skilled providers in facilities.
    [Show full text]
  • Next-Generation Lab-On-A-Chip Devices
    Next-generation lab-on-a-chip devices Samuel Sia, Ph.D. Associate Professor Department of Biomedical Engineering Columbia University APHL, Little Rock June 4, 2014 Clinical ELISA testing... ELISA ideal method low cost? - capital -per test compact? rapid? simple to operate? sensitive (pM)? distinguishes quantitative differences? amenable to parallel analysis? operable without ground electricity? works in field conditions (sunlight)? • coat surface with antigen (overnight) • block with 1% BSA or 0.05% Tween-20 (1 hr) uses accessible • add sample containing antibody to be tested (1 hr) reagents? • add enzyme-conjugated antibody (1 hr) • add substrate (10 min.) “Plug-in cartridge” (bubble-based reagent delivery) 17 pM 170 pM 1.7 nM 17 nM 170 nM 1.7 M Fluorescent antibody Sample Wash Wash Fluorescent Air spacers antibody 200 m Vacuum Antibody in sample Antigen 1200 1000 800 500-m 600 width 250-m 400 50-m width width total time = 2 min. 200 500-m (hands-free) width 0 Normalized fluorescence (a.u.) fluorescence Normalized 0.1 10 1000 Concentration of anti-rabbit IgG (nM) Linder, Sia, and Whitesides, Anal. Chem., 77:64 (2005) Silver reduction enables the use of microfluidics Angew Chemie, 43:498 (2004) ELISA mChip signal generation enzyme/substrate silver precipitation reaction (photography) light source lasers, lenses, filters LEDs (ambient lighting) detector photomultiplier tubes photodetector (photocopier) manufacturing plastic 96-well plates injection-molded plastic (consumer toys) Point-of-care ELISA Founded in 2004 (with Vincent Linder and David Steinmiller), based in Boston area raised ~$12M in VC funding First product: prostate cancer monitoring ISO-certified manufacturing facility and clean room approved in Europe (CE Mark) acquired by Opko Health in 2011 (~$50M) awaiting FDA approval and launch of PSA test and eventually 4K panel (total PSA, free PSA, intact PSA, HK2) Clinical scenario Pregnant woman in high burden-of-disease area (health clinic in U.S.
    [Show full text]
  • Principle of Infection
    23/09/56 Principle of Infection La-or Chompuk, M.D. Department of pathology Faculty of Medicine Infection • Definition: Invasion and multiplication of microorganisms in body tissues • No symptom, local cellular injury, localized symptom, dissemination • Mechanism; competitive metabolism, toxins, intracellular replication, immune response 1 23/09/56 Classification of infectious agents: - classification according to structure - classification according to pathogenesis - classification according to site of multiplication Classification according to structure - Prion - Fungi - Viruses - Protozoa, metazoa - Bacteria - Ectoparasite - Rickettsia, chlamydia, mycoplasma 2 23/09/56 Classification according to pathogenesis • Pathogenic agents; - Virulence: the degree of pathogenicity of a microorganism - Indicated by the severity of disease, the ability to invade tissue - high virulence - low virulence • Opportunistic infection Classification according to site of multiplication - obligate intracellular organisms; Prions, viruses, rickettsiae, chlamydia, some protozoa - facultative intracellular organism; Mycobacteria, Actinomyces, Pseudomonas spp. - extracellular organisms; mycoplasma, fungi, bacteria, metazoa 3 23/09/56 Pathogenesis of Infectious Disease -Host - Pathogen; organism or parasite that cause disease Host factors: 1. General factors; socioeconomic status, behavior pattern, occupational, and internal factors 2. Natural defense mechanism; skin and normal flora, respiratory tract and mucociliary mechanism, Hcl production in stomach, or
    [Show full text]
  • Equity Matters: Lessons from MCHIP and CSHGP in Measuring and Improving Equity
    Equity Matters: Lessons from MCHIP and CSHGP in Measuring and Improving Equity June 2014 Authors: Jennifer Winestock Luna Tanvi Monga Lindsay Morgan Suggested citation: Winestock Luna J, Monga T, and Morgan L. 2014. Equity Matters – Lessons from MCHIP and CSHGP in Measuring and Improving Equity. Maternal Child Health Integrated Program. This report was made possible by the generous support of the American people through the United States Agency for International Development (USAID), under the terms of the Leader with Associates Cooperative Agreement GHS-A-00-08-00002-00. The contents are the responsibility of the Maternal and Child Health Integrated Program (MCHIP) and do not necessarily reflect the views of USAID or the United States Government. The Maternal and Child Health Integrated Program (MCHIP) is the USAID Bureau for Global Health’s flagship maternal, neonatal and child health (MNCH) program. MCHIP supports programming in maternal, newborn and child health, immunization, family planning, malaria, nutrition, and HIV/AIDS, and strongly encourages opportunities for integration. Cross-cutting technical areas include water, sanitation, hygiene, urban health and health systems strengthening. www.mchip.net Table of Contents ABBREVIATIONS AND ACRONYMS ......................................................................................................... iv INTRODUCTION ....................................................................................................................................... 1 CONTRIBUTIONS BY MCHIP AND
    [Show full text]
  • Reaching Underserved Populations: Leveraging Point-Of-Care Tests for Sexually Transmitted and Blood-Borne Infections to Explore New Program Options in Canada
    Reaching Underserved Populations: Leveraging Point-of-Care Tests for Sexually Transmitted and Blood-Borne Infections to Explore New Program Options in Canada Review of the Evidence March, 2018 Prepared by Megan Smallwood, MSc, Reaching Underserved populations: Leveraging Point-of-Care Tests for Sexually Transmitted and Blood-Borne Infections to Explore New Program Options in Canada Review of the Evidence March, 2018 Prepared by Megan Smallwood, MSc Contact us at: National Collaborating Centre for Infectious Diseases Rady Faculty of Health Sciences, University of Manitoba Tel: (204) 318‐2591 Email: [email protected] www.nccid.ca This is NCCID Project number 382 Production of this document has been made possible through a financial contribution from the Public Health Agency of Canada through funding for the National Collaborating Centre for Infectious Diseases. The views expressed herein do not necessarily represent the views of the Public Health Agency of Canada. Table of Contents Introduction .................................................................................................................................................. 1 Sexually Transmitted and Blood‐borne Infections (STBBIs) in Canada ..................................................... 1 Point‐of‐Care Diagnostics ......................................................................................................................... 2 Aim of this Evidence Review ....................................................................................................................
    [Show full text]
  • Cultural Beliefs and Perceptions of Maternal Diet and Weight Gain During Pregnancy and Postpartum Family Planning in Egypt
    Cultural Beliefs and Perceptions of Maternal Diet and Weight Gain during Pregnancy and Postpartum Family Planning in Egypt Authors: Justine Kavle, Sohair Mehanna, Ghada Khan, Mohamed Hassan, Gulsen Saleh, and Rae Galloway April 2014 Table of Contents TABLES AND FIGURES ........................................................................................................................... iv ACKNOWLEDGMENTS ............................................................................................................................ v ABBREVIATIONS .................................................................................................................................... vi EXECUTIVE SUMMARY .......................................................................................................................... vii Introduction .................................................................................................................................................... vii Methods.......................................................................................................................................................... vii Key Findings .................................................................................................................................................. viii Discussion and Recommendations ................................................................................................................ x Conclusion ......................................................................................................................................................
    [Show full text]
  • Dual Elimination of Mother-To-Child Transmission of HIV and Congenital Syphilis DIAGNOSTIC TECHNOLOGY LANDSCAPE
    2014 Dual elimination of mother-to-child transmission of HIV and congenital syphilis DIAGNOSTIC TECHNOLOGY LANDSCAPE APRIL 2014 UNITAID Secretariat World Health Organization Avenue Appia 20 CH-1211 Geneva 27 Switzerland T +41 22 791 55 03 F +41 22 791 48 90 [email protected] www.unitaid.eu UNITAID is hosted and administered by the World Health Organization © 2014 World Health Organization (Acting as the host organization for the Secretariat of UNITAID) The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind either expressed or implied. The responsibility and use of the material lies with the reader. In no event shall the World Health Organization be liable for damages arising from its use. This report was prepared by Maurine M. Murtagh with support from the Bill & Melinda Gates Foundation and UNITAID. All reasonable precautions have been taken by the author to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either expressed or implied.
    [Show full text]
  • Parasites in Liver & Biliary Tree
    Parasites in Liver & Biliary tree Luis S. Marsano, MD Professor of Medicine Division of Gastroenterology, Hepatology and Nutrition University of Louisville & Louisville VAMC 2011 Parasites in Liver & Biliary Tree Hepatic Biliary Tree • Protozoa • Protozoa – E. histolytica – Cryptosporidiasis – Malaria – Microsporidiasis – Babesiosis – Isosporidiasis – African Trypanosomiasis – Protothecosis – S. American Trypanosomiasis • Trematodes – Visceral Leishmaniasis – Fascioliasis – Toxoplasmosis – Clonorchiasis • Cestodes – Opistorchiasis – Echynococcosis • Nematodes • Trematodes – Ascariasis – Schistosomiasis • Nematodes – Toxocariasis – Hepatic Capillariasis – Strongyloidiasis – Filariasis Parasites in the Liver Entamoeba histolytica • Organism: E. histolytica is a Protozoa Sarcodina that infects 1‐ 5% of world population and causes 100000 deaths/y. – (E. dispar & E. moshkovskii are morphologically identical but only commensal; PCR or ELISA in stool needed to differentiate). • Distribution: worldwide; more in tropics and areas with poor sanitation. • Location: colonic lumen; may invade crypts and capillaries. More in cecum, ascending, and sigmoid. • Forms: trophozoites (20 mcm) or cysts (10‐20 mcm). Erytrophagocytosis is diagnostic for E. histolytica trophozoite. • Virulence: may increase with immunosuppressant drugs, malnutrition, burns, pregnancy and puerperium. Entamoeba histolytica • Clinical forms: – I) asymptomatic; – II) symptomatic: • A. Intestinal: – a) Dysenteric, – b) Nondysenteric colitis. • B. Extraintestinal: – a) Hepatic: i) acute
    [Show full text]
  • (IPT) of Malaria in Pregnancy
    Malaria Policy Advisory Committee Meeting 11-13 September 2013, Crowne Plaza Hotel, Geneva Session 4.1 WHO Evidence Review Group on Intermittent Preventive Treatment (IPT) of malaria in pregnancy WHO Headquarters, Geneva, 9-11 July 2013 Draft Recommendations on Intermittent Preventive Treatment in Pregnancy (IPTp) The recommendations outlined below build on the WHO IPTp Policy (October 2012), and should be considered by countries with specific patterns of SP resistance, or a persistent reduction in malaria transmission and by those considering mefloquine as an alternative medicine for IPTp. The ERG proposed the following recommendations for consideration by the MPAC: Recommendation 1: Consider discontinuing IPTp-SP when the population prevalence of Plasmodium falciparum (Pf) dhps mutation K540E is greater than 95%, AND the prevalence of mutation A581G is greater than 10%, as it is likely to be ineffective. In areas where IPTp-SP is discontinued because of resistance, ensure access of pregnant women to long-lasting insecticide treated nets and prompt diagnosis and effective treatment. Key Background Points: • The evidence reviewed indicated that IPTp-SP continues to be effective in areas of moderate SP resistance. • Marked regional differences in the prevalence of P. falciparum genotypes responsible for SP resistance have been documented, indicating that continued monitoring of resistance markers is needed, especially in East and Southern Africa where antifolate resistance in P. falciparum is highest. Monitoring of SP resistance should focus on the P. falciparum dhps A581G and K540E mutations; in West Africa the prevalence of P. falciparum dhps A437G should also be monitored, as its increasing prevalence has been associated with progressive reduction in IPTp-SP effectiveness.
    [Show full text]
  • Born Too Soon: Care for the Preterm Baby
    Lawn et al. Reproductive Health 2013, 10(Suppl 1):S5 http://www.reproductive-health-journal.com/content/10/S1/S5 REVIEW Open Access Born Too Soon: Care for the preterm baby Joy E Lawn*1,2, Ruth Davidge3,4,5, Vinod K Paul6, Severin von Xylander7, Joseph de Graft Johnson8, Anthony Costello9, Mary V Kinney10, Joel Segre11 and Liz Molyneux12 Abstract As part of a supplement entitled “Born Too Soon”, this paper focuses on care of the preterm newborn. An estimated 15 million babies are born preterm, and the survival gap between those born in high and low income countries is widening, with one million deaths a year due to direct complications of preterm birth, and around one million more where preterm birth is a risk factor, especially amongst those who are also growth restricted. Most premature babies (>80%) are between 32 and 37 weeks of gestation, and many die needlessly for lack of simple care. We outline a series of packages of care that build on essential care for every newborn comprising support for immediate and exclusive breastfeeding, thermal care, and hygienic cord and skin care. For babies who do not breathe at birth, rapid neonatal resuscitation is crucial. Extra care for small babies, including Kangaroo Mother Care, and feeding support, can halve mortality in babies weighing <2000 g. Case management of newborns with signs of infection, safe oxygen management and supportive care for those with respiratory complications, and care for those with signifi cant jaundice are all critical, and are especially dependent on competent nursing care. Neonatal intensive care units in high income settings are de-intensifying care, for example increasing use of continuous positive airway pressure (CPAP) and this makes comprehensive preterm care more transferable.
    [Show full text]