List of Medical Device Clinical Trial Filing Institutions
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Appendix Iii Property Valuation
APPENDIX III PROPERTY VALUATION The following is the text of a letter with the summary of values and valuation certificate received from CB Richard Ellis Limited, prepared for the purpose of incorporation in the prospectus, in connection with their valuation as at 31 October 2010 of all the property interests of the Group. 4/F Three Exchange Square 8 Connaught Place Central, Hong Kong T 852 2820 2800 F 852 2810 0830 香港中環康樂廣場八號交易廣場第三期四樓 電話 852 2820 2800 傳真 852 2810 0830 www.cbre.com.hk 地產代理(公司)牌照號碼 Estate Agent’s Licence No: C-004065 15 December 2010 The Board of Directors, China Animal Healthcare Ltd., No. 6 Kangding Street, Yi Zhuang Economic Development Zone, Beijing City, the People’s Republic of China Dear Sirs, In accordance with your instructions for us to value the property interests held by China Animal Healthcare Ltd. (the ‘‘Company’’) and its subsidiaries (hereinafter together know as the ‘‘Group’’)inthePeople’s Republic of China (the ‘‘PRC’’). We confirm that we have carried out inspections, made relevant enquiries and obtained such further information as we consider necessary for the purpose of providing you with our opinion of the capital values of such property interests as at 31 October 2010 (the ‘‘date of valuation’’). Our valuation is our opinion of Market Value which is defined to mean ‘‘the estimated amount for which a property should exchange on the date of valuation between a willing buyer and a willing seller in an arm’s-length transaction after proper marketing wherein the parties had each acted knowledgeably, prudently and without compulsion.’’ Unless otherwise stated, our valuation is prepared in accordance with the ‘‘First Edition of The HKIS Valuation Standards on Properties’’ published by The Hong Kong Institute of Surveyors (‘‘HKIS’’). -
Cartoon Game Industry; Cluster; Creative Class; Structure
International Conference on Education Technology and Social Science (ICETSS 2014) Research on Cultivation of Creative Class under Industrial Environment Cluster-- Take Cartoon Game Industry as an Example Lie Chen Sichuan University, Chengdu, 610000, China Keywords: cartoon game industry; cluster; creative class; structure Abstract. This research takes Chengdu national-level culture creative industry park as an example to pay attention to the current situation of cluster cultivation of creative class of Chengdu cartoon game industry under cluster environment. Through deep research on typical cartoon culture creativity enterprises, this paper carries out analysis on various factors influencing development of Chengdu professional cartoon creative talents, and proposes the solution for cultivation of creative talents based on the thought of cluster development of creative industry. The concept of industrial cluster firstly appeared in the book The Competitive Advantage of Nations written by Michael E. Porter and published in 1990. So far, as a kind of extremely special industrial organization form, the industrial cluster has gradually become an important economic phenomenon in world economic development. The powerful technology and knowledge overflow effect brought by industrial cluster is widely affecting industrialization and urbanization process of a region and even whole country. The cartoon industry which centers on Sichuan Chengdu is gradually forming Southwest cartoon industry development zone led by games and wireless entertainment. In the development process “from industrial concentration to grouping and cluster”, the spatial arrangement of Chengdu cultural creative industry cluster has basically taken the shape, and the creative class cluster is basically formed. Currently, there are more than 520 software enterprises in Chengdu, including more than 60 online game enterprises. -
Some Special Elements and Pseudo Inverse Functions in Groupoids
mathematics Article Some Special Elements and Pseudo Inverse Functions in Groupoids Yong Lin Liu 1, Hee Sik Kim 2,* and Joseph Neggers 3 1 School of Mathematics and Finance, Putian University, Putian 351100, Fujian, China; [email protected] 2 Research Institute of Natural Sciences, Department of Mathematics, Hanyang University, Seoul 04763, Korea 3 Department of Mathematics, University of Alabama, Tuscaloosa, AL 35487-0350, USA; [email protected] * Correspondence: [email protected]; Tel.: +82-10-9276-5630 or +82-2-2220-0897 Received: 6 December 2018; Accepted: 9 February 2019; Published: 14 February 2019 Abstract: In this paper, we consider a theory of elements u of a groupoid (X, ∗) that are associated with certain functions ub : X ! X, pseudo-inverse functions, which are generalizations of the inverses associated with units of groupoids with identity elements. If classifying the elements u as special of one of twelve types, then it is possible to do a rather detailed analysis of certain cases, leftoids, rightoids and linear groupoids included, which demonstrates that it is possible to develop a successful theory and that a good deal of information has already been obtained with much more possible in the future. Keywords: (completely) (LL-) special element; pseudo inverse; linear groupoid 1. Introduction Bruck [1] published a book, A survey of binary systems discussed in the theory of groupoids, loops and quasigroups, and several algebraic structures. Boru˙ vka [2] stated the theory of decompositions of sets and its application to binary systems. Recently, some interesting results in groupoids were investigated by several researchers [3–6]. Semigroups are in fact the first and simplest type of algebra to which the methods of universal algebra must be applied, and any mathematician interested in universal algebra will find semigroup theory a rewarding study [7]. -
Role of PARP1-Mediated Autophagy in EGFR-TKI Resistance in Non
www.nature.com/scientificreports OPEN Role of PARP1‑mediated autophagy in EGFR‑TKI resistance in non‑small cell lung cancer Zhimin Zhang1,4, Xiaojuan Lian2,4, Wei Xie1, Jin Quan2, Maojun Liao1, Yan Wu3, Zhen‑Zhou Yang3,4* & Ge Wang1,4* Resistance to epidermal growth factor receptor‑tyrosine kinase inhibitors (EGFR‑TKIs) has become the main clinical challenge of advanced lung cancer. This research aimed to explore the role of PARP1‑ mediated autophagy in the progression of TKI therapy. PARP1‑mediated autophagy was evaluated in vitro by CCK‑8 assay, clonogenic assay, immunofuorescence, and western blot in the HCC‑827, H1975, and H1299 cells treated with icotinib (Ico), rapamycin, and AZD2281 (olaparib) alone or in combination. Our results and GEO dataset analysis confrmed that PARP1 is expressed at lower levels in TKI‑sensitive cells than in TKI‑resistant cells. Low PARP1 expression and high p62 expression were associated with good outcomes among patients with NSCLC after TKI therapy. AZD2281 and a lysosomal inhibitor reversed resistance to Ico by decreasing PARP1 and LC3 in cells, but an mTOR inhibitor did not decrease Ico resistance. The combination of AZD2281 and Ico exerted a markedly enhanced antitumor efect by reducing PARP1 expression and autophagy in vivo. Knockdown of PARP1 expression reversed the resistance to TKI by the mTOR/Akt/autophagy pathway in HCC‑827IR, H1975, and H1299 cells. PARP1‑mediated autophagy is a key pathway for TKI resistance in NSCLC cells that participates in the resistance to TKIs. Olaparib may serve as a -
A Neighbourhood Under Storm Zhabei and Shanghai Wars
European Journal of East Asian Studies EJEAS . () – www.brill.nl/ejea A Neighbourhood under Storm Zhabei and Shanghai Wars Christian Henriot Institut d’Asie orientale, Université de Lyon—Institut Universitaire de France [email protected] Abstract War was a major aspect of Shanghai history in the first half of the twentieth century. Yet, because of the particular political and territorial divisions that segmented the city, war struck only in Chinese-administered areas. In this paper, I examine the fate of the Zhabei district, a booming industrious area that came under fire on three successive occasions. Whereas Zhabei could be construed as a success story—a rag-to-riches, swamp-to-urbanity trajectory—the three instances of military conflict had an increasingly devastating impact, from shaking, to stifling, to finally erase Zhabei from the urban landscape. This area of Shanghai experienced the first large-scale modern warfare in an urban setting. The skirmish established the pattern in which the civilian population came to be exposed to extreme forms of violence, was turned overnight into a refugee population, and lost all its goods and properties to bombing and fires. Keywords war; Shanghai; urban; city; civilian; military War is not the image that first comes to mind about Shanghai. In most accounts or scholarly studies, the city stands for modernity, economic prosperity and cultural novelty. It was China’s main financial centre, commercial hub, indus- trial base and cultural engine. In its modern history, however, Shanghai has experienced several instances of war. One could start with the takeover of the city in by the Small Sword Society and the later attempts by the Taip- ing armies to approach Shanghai. -
MCP-Induced Protein 1 Attenuates Sepsis-Induced Acute Lung Injury By
International Immunopharmacology 75 (2019) 105741 Contents lists available at ScienceDirect International Immunopharmacology journal homepage: www.elsevier.com/locate/intimp MCP-induced protein 1 attenuates sepsis-induced acute lung injury by T modulating macrophage polarization via the JNK/c-Myc pathway ⁎ Yang Zhanga, Tianfeng Huangb, Lulu Jianga, Ju Gaob, , Dapeng Yua, Yali Gea, Shunyan Linb a Department of Anesthesiology, Institute of Anesthesia, Emergency and Critical Care, Subei People's Hospital of Jiangsu Province, XiangYa School of Medicine, Central South University,China b Department of Anesthesiology, Institute of Anesthesia, Emergency and Critical Care, Subei People's Hospital of Jiangsu Province, China ARTICLE INFO ABSTRACT Keywords: Sepsis is a potentially fatal systemic inflammatory response syndrome caused by infection. In this study, we evaluated MCP-induced protein 1 the effects of MCP-induced protein 1 (MCPIP1), a recently discovered inflammation-related ribonuclease, onsepsis- Macrophage polarization induced acute lung injury (ALI) and investigated the underlying mechanisms. Cecal ligation puncture and lipopo- JNK lysaccharide induction were performed on Sprague-Dawley rats and RAW264.7 cells, respectively, to establish sepsis- Sepsis induced ALI models. The proteasome inhibitor MG132 used as an activator of MCPIP1 overexpression, and we Acute lung injury showed that MG132 can indeed increase the expression of MCPIP1. MCPIP1 overexpression induced by MG132 alleviated sepsis-induced pathologic changes, water content and protein leakage in the lungs, and induction of systemic inflammatory mediators, and improved the 7-day mortality rate in the model rats. We also showedthat MCPIP1 p showed romoted macrophage polarization from the M1 to the M2 type in sepsis-induced ALI. Furthermore, MCPIP1-enhanced M2 polarization was inhibited by an MCPIP1-targeting small interfering RNA (siMCPIP1) in RAW264.7 cells. -
The Globalization of Chinese Food ANTHROPOLOGY of ASIA SERIES Series Editor: Grant Evans, University Ofhong Kong
The Globalization of Chinese Food ANTHROPOLOGY OF ASIA SERIES Series Editor: Grant Evans, University ofHong Kong Asia today is one ofthe most dynamic regions ofthe world. The previously predominant image of 'timeless peasants' has given way to the image of fast-paced business people, mass consumerism and high-rise urban conglomerations. Yet much discourse remains entrenched in the polarities of 'East vs. West', 'Tradition vs. Change'. This series hopes to provide a forum for anthropological studies which break with such polarities. It will publish titles dealing with cosmopolitanism, cultural identity, representa tions, arts and performance. The complexities of urban Asia, its elites, its political rituals, and its families will also be explored. Dangerous Blood, Refined Souls Death Rituals among the Chinese in Singapore Tong Chee Kiong Folk Art Potters ofJapan Beyond an Anthropology of Aesthetics Brian Moeran Hong Kong The Anthropology of a Chinese Metropolis Edited by Grant Evans and Maria Tam Anthropology and Colonialism in Asia and Oceania Jan van Bremen and Akitoshi Shimizu Japanese Bosses, Chinese Workers Power and Control in a Hong Kong Megastore WOng Heung wah The Legend ofthe Golden Boat Regulation, Trade and Traders in the Borderlands of Laos, Thailand, China and Burma Andrew walker Cultural Crisis and Social Memory Politics of the Past in the Thai World Edited by Shigeharu Tanabe and Charles R Keyes The Globalization of Chinese Food Edited by David Y. H. Wu and Sidney C. H. Cheung The Globalization of Chinese Food Edited by David Y. H. Wu and Sidney C. H. Cheung UNIVERSITY OF HAWAI'I PRESS HONOLULU Editorial Matter © 2002 David Y. -
Clifford Modern Living Holdings Limited 祈福
THIS CIRCULAR IS IMPORTANT AND REQUIRES YOUR IMMEDIATE ATTENTION If you are in any doubt as to any aspect of this circular or as to the action to be taken, you should consult a stockbroker or other licensed securities dealer, bank manager, solicitor, professional accountant or other professional advisers. If you have sold or transferred all your shares in Clifford Modern Living Holdings Limited 祈福生活服務控股 有限公司, you should at once hand this circular and the accompanying form of proxy to the purchaser(s) or the transferee(s) or to the bank, stockbroker or licensed securities dealer or other agent through whom the sale or transfer was effected for transmission to the purchaser(s) or the transferee(s). Hong Kong Exchanges and Clearing Limited and The Stock Exchange of Hong Kong Limited take no responsibility for the contents of this circular, make no representation as to its accuracy or completeness and expressly disclaim any liability whatsoever for any loss howsoever arising from or in reliance upon the whole or any part of the contents of this circular. CLIFFORD MODERN LIVING HOLDINGS LIMITED 祈福生活服務控股有限公司 (Incorporated in the Cayman Islands with limited liability) (Stock Code: 3686) CONTINUING CONNECTED TRANSACTIONS: RESPECTIVE SUPPLEMENTAL AGREEMENTS TO THE MASTER TENANCY AGREEMENT AND THE MASTER COMPOSITE SERVICES AGREEMENT AND REVISION OF ANNUAL CAPS Independent Financial Adviser to the Independent Board Committee and the Independent Shareholders A letter from the Board is set out on pages 6 to 19 of this circular. A letter from the Independent Board Committee containing its recommendation to the Independent Shareholders is set out on pages 20 to 21 of this circular. -
Human Streptococcus Suis Outbreak, Sichuan, China
RESEARCH Human Streptococcus suis Outbreak, Sichuan, China Hongjie Yu,*1 Huaiqi Jing,†1 Zhihai Chen,‡1 Han Zheng,† Xiaoping Zhu,§ Hua Wang,¶ Shiwen Wang,* Lunguang Liu,§ Rongqiang Zu,* Longze Luo,§ Nijuan Xiang,* Honglu Liu,§ Xuecheng Liu,§ Yuelong Shu,* Shui Shan Lee,# Shuk Kwan Chuang,** Yu Wang,* Jianguo Xu,† Weizhong Yang,* and the Streptococcus suis study groups2 From mid-July to the end of August 2005, a total of 215 Sporadic cases of S. suis infection may occur in cases of human Streptococcus suis infections, 66 of which humans, the most common clinical manifestations includ- were laboratory confirmed, were reported in Sichuan, ed purulent meningitis, septicemia, arthritis, and endo- China. All infections occurred in backyard farmers who carditis; some infections lead to sequelae such as deafness were directly exposed to infection during the slaughtering and ataxia (5–7). To date, ≈200 human cases have been process of pigs that had died of unknown causes or been killed for food because they were ill. Sixty-one (28%) of the reported in areas of intensive pig rearing (the Netherlands, farmers had streptococcal toxic shock syndrome; 38 (62%) Denmark) or areas where large quantities of pork are eaten of them died. The other illnesses reported were sepsis (Hong Kong, Thailand, Vietnam) (8). Most reported cases (24%) and meningitis (48%) or both. All isolates tested pos- of human S. suis infections were associated with contact itive for genes for tuf, species-specific 16S rRNA, cps2J, with pigs or pork products (5). Human S. suis infections do mrp, ef, and sly. A single strain of S. -
Century Journals Project (CJP)
China National Knowledge Infrastructure: Century Journals Project (CJP) Complete Title List - Series E (at July, 2008) Please note: Titles are sorted by Series, then Language (with English titles appearing first) , then by Pinyin title in English phonetic order. Earliest Control Journal Title Language Title in Pinyin Glossing of Title Former Title Freq. ISSN # CN # Publisher Issue in Status URL Notes Code Series CNKI E 南京医科大学学报 (英文版) English Nanjing Yike Daxue Xuebao (Yingwenban) Journal of Nanjing Medical University Journal of Nan bimonthly 1007-4376 32-1443/R 南京医科大学 1994/01 Active http://china.eastview.com/kns50/Navi/Bridge.aspx?L NJYY E 上海第二医科大学学报 (外文版) English Shanghai Dier Yike Daxue Xuebao Journal of Shanghai Second Medical University Journal of Sha semiannual 1001-6686 31-1589/R 上海第二医科大学 1987/01 Active http://china.eastview.com/kns50/Navi/Bridge.aspx?L SHEI (Yingwenban) (Foreign Language Edition) E 生物医学与环境科学 (英文版) English Shengwu Yi Xue Yu Huan Jing Ke Xue Biomedical and Environmental Sciences Biomedical an bimonthly 0895-3988 11-2816/Q 中国预防医学科学 1989/01 Active http://china.eastview.com/kns50/Navi/Bridge.aspx?L SWYX (Yingwenban) E 生殖与避孕 (英文版) English Shengzhi Yu Biyun (Yingwenban) Journal of Reproduction and Contraception Reproduction quarterly 1001-7844 31-1555/R 上海市计划生育科 1994/01 Active http://china.eastview.com/kns50/Navi/Bridge.aspx?L SZBW E 世界针灸杂志 (英文版) English Shijie Zhenjiu Zazhi (Yingwenban) World Journal of Acupuncture-Moxibustion World Journa quarterly 1003-5257 11-2892/R 世界针灸学会联合会 1992/01 Active http://china.eastview.com/kns50/Navi/Bridge.aspx?L -
Astragaloside IV Attenuates Cerebral Ischemia‑Reperfusion Injury in Rats Through the Inhibition of Calcium‑Sensing Receptor‑Mediated Apoptosis
302 INTERNATIONAL JOURNAL OF MOleCular meDICine 47: 302-314, 2021 Astragaloside IV attenuates cerebral ischemia‑reperfusion injury in rats through the inhibition of calcium‑sensing receptor‑mediated apoptosis SHU-JIN DU1, YING ZHANG1, YAN-MENG ZHAO1, YA-JIE DONG2, JING-LONG TANG3, XIAO-HONG ZHOU1 and WEI-JUAN GAO1 1Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200; 2Department of Pathophysiology, Chengde Medical College, Chengde, Hebei 067000; 3The Reproductive Genetics Laboratory, Jinan Adicon Clinical Labor, Binzhou, Shandong 256600, P.R. China Received May 7, 2020; Accepted October 8, 2020 DOI: 10.3892/ijmm.2020.4777 Abstract. Cerebral ischemia-reperfusion injury (CIRI), CaSR may be involved in CIRI-induced brain damage in rats, caused by the reperfusion of blocked vessels following isch- and that Astragaloside IV may alleviate CIRI by inhibiting emic stroke, can lead to secondary brain injury. Throughout CaSR activation-induced apoptosis. CIRI, apoptosis serves an important role. Astragaloside IV is a potential neuroprotectant that alleviates CIRI by inhib- Introduction iting apoptosis. The calcium-sensing receptor (CaSR) is a G-protein-coupled receptor, the activation of which aggravates Acute ischemic stroke (AIS) is the most frequent cause of ischemia-reperfusion injury. The aim of the present study was permanent disability in adults worldwide (1). Due to its to investigate whether the protective effect of Astragaloside IV high incidence, disability and recurrence rate, as well as on CIRI may be associated with the regulation of CaSR. A complications, AIS has become a severe threat to human rat middle cerebral artery occlusion/reperfusion (MCAO/R) health and quality of life (2). -
Polymer Induced One-Step Interfacial Self-Assembly Method for The
Electronic Supplementary Material (ESI) for Nanoscale. This journal is © The Royal Society of Chemistry 2019 Polymer induced one-step interfacial self-assembly method for the fabrication of flexible, robust and free-standing SERS substrates for rapid on-site detection of pesticide residues Peng Wu,a Lu-Bin Zhong,*,a,b,c Qing Liu,a,d Xi Zhou,e and Yu-Ming Zheng*a,b,c aCAS Key Laboratory of Urban Pollutant Conversion, Institute of Urban Environment, Chinese Academy of Sciences, 1799 Jimei Road, Xiamen 361021, China bCAS Center for Excellence in Regional Atmospheric Environment, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China cUniversity of Chinese Academy of Sciences, 19A Yuquan Road, Beijing 100049, China dFujian Provincial Key Laboratory of Ecology-Toxicological Effects & Control for Emerging Contaminants, Putian University, Putian 351100, China eDepartment of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, China Corresponding authors: *E-mail: [email protected] (L.B. Zhong) *E-mail: [email protected] (Y.M. Zheng) EF calculation Enhanced factor was calculated by the equation as below: I / N cN hI EF SER SER A SER I NRS / N NRS RI NRS where c is the concentration of 4-ATP in ethanol, NA is the Avogadro constant, σ is the surface area occupied by an adsorbed 4-ATP molecule, and R is the roughness factor of the AuNPs/PVC film, h is the effective waist. In this work, c is 0.01 mol·L-1, 23 -1 2 NA is 6.02×10 mol , σ is 0.2 nm , h is 60 μm, R is 2, the calculated result was 3.7×106.