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Astragaloside IV Attenuates Cerebral Ischemia‑Reperfusion Injury in Rats Through the Inhibition of Calcium‑Sensing Receptor‑Mediated Apoptosis
302 INTERNATIONAL JOURNAL OF MOleCular meDICine 47: 302-314, 2021 Astragaloside IV attenuates cerebral ischemia‑reperfusion injury in rats through the inhibition of calcium‑sensing receptor‑mediated apoptosis SHU-JIN DU1, YING ZHANG1, YAN-MENG ZHAO1, YA-JIE DONG2, JING-LONG TANG3, XIAO-HONG ZHOU1 and WEI-JUAN GAO1 1Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200; 2Department of Pathophysiology, Chengde Medical College, Chengde, Hebei 067000; 3The Reproductive Genetics Laboratory, Jinan Adicon Clinical Labor, Binzhou, Shandong 256600, P.R. China Received May 7, 2020; Accepted October 8, 2020 DOI: 10.3892/ijmm.2020.4777 Abstract. Cerebral ischemia-reperfusion injury (CIRI), CaSR may be involved in CIRI-induced brain damage in rats, caused by the reperfusion of blocked vessels following isch- and that Astragaloside IV may alleviate CIRI by inhibiting emic stroke, can lead to secondary brain injury. Throughout CaSR activation-induced apoptosis. CIRI, apoptosis serves an important role. Astragaloside IV is a potential neuroprotectant that alleviates CIRI by inhib- Introduction iting apoptosis. The calcium-sensing receptor (CaSR) is a G-protein-coupled receptor, the activation of which aggravates Acute ischemic stroke (AIS) is the most frequent cause of ischemia-reperfusion injury. The aim of the present study was permanent disability in adults worldwide (1). Due to its to investigate whether the protective effect of Astragaloside IV high incidence, disability and recurrence rate, as well as on CIRI may be associated with the regulation of CaSR. A complications, AIS has become a severe threat to human rat middle cerebral artery occlusion/reperfusion (MCAO/R) health and quality of life (2). -
List of Medical Device Clinical Trial Filing Institutions
List Of Medical Device Clinical Trial Filing Institutions Serial Record number Institution name number Beijing: 5 6 Ge Mechanical temporary 1 agency Beijing Tsinghua Chang Gung Memorial Hospital preparation 201800003 Mechanical temporary 2 agency Plastic Surgery Hospital of Chinese Academy of Medical Sciences preparation 201800008 Mechanical temporary 3 agency Beijing Youan Hospital, Capital Medical University preparation 201800019 Mechanical temporary 4 agency Peking University Shougang Hospital preparation 201800044 Mechanical temporary 5 agency Beijing Cancer Hospital preparation 201800048 Mechanical temporary 6 agency Eye Hospital of China Academy of Chinese Medical Sciences preparation 201800077 Mechanical temporary Beijing Traditional Chinese Medicine Hospital Affiliated to Capital Medical 7 agency University preparation 201800086 Mechanical temporary 8 agency Beijing Anorectal Hospital (Beijing Erlong Road Hospital) preparation 201800103 Mechanical temporary 9 agency Cancer Hospital of Chinese Academy of Medical Sciences preparation 201800108 Serial Record number Institution name number Mechanical temporary Peking Union Medical College Hospital, Chinese Academy of Medical 10 agency Sciences preparation 201800119 Mechanical temporary 11 agency Beijing Luhe Hospital, Capital Medical University preparation 201800128 Mechanical temporary 12 agency Beijing Huilongguan Hospital preparation 201800183 Mechanical temporary 13 agency Beijing Children's Hospital, Capital Medical University preparation 201800192 Mechanical temporary 14 agency -
Addition of Clopidogrel to Aspirin in 45 852 Patients with Acute Myocardial Infarction: Randomised Placebo-Controlled Trial
Articles Addition of clopidogrel to aspirin in 45 852 patients with acute myocardial infarction: randomised placebo-controlled trial COMMIT (ClOpidogrel and Metoprolol in Myocardial Infarction Trial) collaborative group* Summary Background Despite improvements in the emergency treatment of myocardial infarction (MI), early mortality and Lancet 2005; 366: 1607–21 morbidity remain high. The antiplatelet agent clopidogrel adds to the benefit of aspirin in acute coronary See Comment page 1587 syndromes without ST-segment elevation, but its effects in patients with ST-elevation MI were unclear. *Collaborators and participating hospitals listed at end of paper Methods 45 852 patients admitted to 1250 hospitals within 24 h of suspected acute MI onset were randomly Correspondence to: allocated clopidogrel 75 mg daily (n=22 961) or matching placebo (n=22 891) in addition to aspirin 162 mg daily. Dr Zhengming Chen, Clinical Trial 93% had ST-segment elevation or bundle branch block, and 7% had ST-segment depression. Treatment was to Service Unit and Epidemiological Studies Unit (CTSU), Richard Doll continue until discharge or up to 4 weeks in hospital (mean 15 days in survivors) and 93% of patients completed Building, Old Road Campus, it. The two prespecified co-primary outcomes were: (1) the composite of death, reinfarction, or stroke; and Oxford OX3 7LF, UK (2) death from any cause during the scheduled treatment period. Comparisons were by intention to treat, and [email protected] used the log-rank method. This trial is registered with ClinicalTrials.gov, number NCT00222573. or Dr Lixin Jiang, Fuwai Hospital, Findings Allocation to clopidogrel produced a highly significant 9% (95% CI 3–14) proportional reduction in death, Beijing 100037, P R China [email protected] reinfarction, or stroke (2121 [9·2%] clopidogrel vs 2310 [10·1%] placebo; p=0·002), corresponding to nine (SE 3) fewer events per 1000 patients treated for about 2 weeks. -
CONICYT Ranking Por Disciplina > Sub-Área OECD (Académicas) Comisión Nacional De Investigación 2
CONICYT Ranking por Disciplina > Sub-área OECD (Académicas) Comisión Nacional de Investigación 2. Ingeniería y Tecnología > 2.11 Otras Ingenierías y Tecnologías Científica y Tecnológica PAÍS INSTITUCIÓN RANKING PUNTAJE INDIA Indian Institute of Technology System (IIT System) 1 5,000 CHINA Harbin Institute of Technology 2 5,000 FRANCE Universite Paris Saclay (ComUE) 3 5,000 CHINA Tsinghua University 4 5,000 GERMANY Technical University of Munich 5 5,000 CHINA Zhejiang University 6 5,000 CHINA Shanghai Jiao Tong University 7 5,000 CHINA Beihang University 8 5,000 SINGAPORE Nanyang Technological University & National Institute of Education 9 5,000 CHINA Huazhong University of Science & Technology 10 5,000 SWITZERLAND ETH Zurich 11 5,000 USA University of California Berkeley 12 5,000 USA Massachusetts Institute of Technology (MIT) 13 5,000 ITALY Polytechnic University of Milan 14 5,000 ITALY University of Naples Federico II 15 5,000 USA University of Maryland College Park 16 5,000 IRAN Islamic Azad University 17 5,000 CHINA South China University of Technology 18 5,000 USA Stanford University 19 5,000 ITALY University of Bologna 20 5,000 SINGAPORE National University of Singapore 21 5,000 USA University of Wisconsin Madison 22 5,000 CHINA Jiangnan University 23 5,000 USA California Institute of Technology 24 5,000 USA Purdue University 25 5,000 BELGIUM Ghent University 26 5,000 USA University of Michigan 27 5,000 NETHERLANDS Wageningen University & Research 28 5,000 GERMANY RWTH Aachen University 29 5,000 BELGIUM KU Leuven 30 5,000 CHINA Wuhan -
Efficacy and Safety of Cinepazide Maleate
Ecacy and safety of cinepazide maleate injection in patients with acute ischemic stroke: A multicenter, randomized, double-blind, placebo- controlled trial Jun Ni Peking Union Medical College Hospital Huisheng Chen General Hospital of Northern Theater Command Guofang Chen Xuzhou Central Hospital Yong Ji Tianjin Huanhu Hospital Fei Yi Pingxiang People's Hospital Zhuobo Zhang Fourth Aliated Hospital of Harbin Medical University Yi Yang First Bethune Hospital of Jilin University Jin Wu Nanjing Medical University Second Aliated Hospital Xueli Cai Lishui Municipal Central Hospital Bei Shao First Aliated Hospital of Wenzhou Medical University Jianfeng Wang Dalian Municipal Central Hospital Yafang Liu Huangshi Central Hospital Deqin Geng Aliated Hospital of Xuzhou Medical College Xinhui Qu Jiangxi Provincial People's Hospital Xiaohong Li Jinan Central Hospital Page 1/26 Yan Wei Hengshui People's Hospital Jianping Ding Xuan Wu Hospital Hua Lu Shaanxi Provincial People's Hospital Yining Huang Peking University First Hospital Yonghua Huang Seventh Medical Center of the Chinese PLA General Hospital Bo Xiao Xiangya Hospital Central South University Tao Gong Beijing Hospital Liying Cui ( [email protected] ) Peking Union Medical College Hospital https://orcid.org/0000-0001-6342-7835 Research article Keywords: acute cerebral infarction; cerebrovascular disease; cinepazide maleate; stroke Posted Date: March 10th, 2020 DOI: https://doi.org/10.21203/rs.3.rs-16499/v1 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Version of Record: A version of this preprint was published on July 14th, 2020. See the published version at https://doi.org/10.1186/s12883-020-01844-8. -
A Complete Collection of Chinese Institutes and Universities For
Study in China——All China Universities All China Universities 2019.12 Please download WeChat app and follow our official account (scan QR code below or add WeChat ID: A15810086985), to start your application journey. Study in China——All China Universities Anhui 安徽 【www.studyinanhui.com】 1. Anhui University 安徽大学 http://ahu.admissions.cn 2. University of Science and Technology of China 中国科学技术大学 http://ustc.admissions.cn 3. Hefei University of Technology 合肥工业大学 http://hfut.admissions.cn 4. Anhui University of Technology 安徽工业大学 http://ahut.admissions.cn 5. Anhui University of Science and Technology 安徽理工大学 http://aust.admissions.cn 6. Anhui Engineering University 安徽工程大学 http://ahpu.admissions.cn 7. Anhui Agricultural University 安徽农业大学 http://ahau.admissions.cn 8. Anhui Medical University 安徽医科大学 http://ahmu.admissions.cn 9. Bengbu Medical College 蚌埠医学院 http://bbmc.admissions.cn 10. Wannan Medical College 皖南医学院 http://wnmc.admissions.cn 11. Anhui University of Chinese Medicine 安徽中医药大学 http://ahtcm.admissions.cn 12. Anhui Normal University 安徽师范大学 http://ahnu.admissions.cn 13. Fuyang Normal University 阜阳师范大学 http://fynu.admissions.cn 14. Anqing Teachers College 安庆师范大学 http://aqtc.admissions.cn 15. Huaibei Normal University 淮北师范大学 http://chnu.admissions.cn Please download WeChat app and follow our official account (scan QR code below or add WeChat ID: A15810086985), to start your application journey. Study in China——All China Universities 16. Huangshan University 黄山学院 http://hsu.admissions.cn 17. Western Anhui University 皖西学院 http://wxc.admissions.cn 18. Chuzhou University 滁州学院 http://chzu.admissions.cn 19. Anhui University of Finance & Economics 安徽财经大学 http://aufe.admissions.cn 20. Suzhou University 宿州学院 http://ahszu.admissions.cn 21. -
Mukden Medical College Was Well Regarded, and in Reports That ‘Its Teachers and Students Fled
J R Coll Physicians Edinb 2006; 36:179–184 PAPER © 2006 Royal College of Physicians of Edinburgh Mukden Medical College (1911–1949): an outpost of Edinburgh medicine in northeast China. Part 2: 1918–1949: expansion, occupation, liberation and merger DS Crawford Emeritus Librarian, McGill University, Montréal, Québec, Canada; Honorary Research Librarian, China Medical University, Shenyang, China ABSTRACT Scottish physician Dugald Christie commenced practice in the city Correspondence to DS Crawford, of Mukden (Shenyang) in Manchuria in 1883. In 1911, he founded the Mukden 135 George Street South, Suite 304 Medical College, the first Western medical school in Manchuria. Edinburgh- Toronto, Ontario trained physicians and surgeons largely staffed the college and in 1934 it Canada M5A 4E8 became the first foreign university to have its medical degree recognised by the University of Edinburgh. It was merged into the China Medical University tel. +1 (416) 504 7636 (Zhongguo yi ke da xue) in 1949. During its separate existence the Mukden e-mail [email protected] Medical College brought modern medicine and medical education to northeastern China, and its legacy continues to influence both medical practice and medical education in China. KEYWORDS China Medical University, Chinese history, Dugald Christie, medical education, missions and missionaries, Mukden Medical College, University of Edinburgh LIST OF ABBREVIATIONS China Medical Board (CMB), China Medical Missionary Association (CMMA), Mukden Medical College (MMC), Peking Union Medical College (PUMC), Royal College of Physicians of Edinburgh (RCPE), Royal College of Surgeons of Edinburgh (RCSEd), South Manchuria Medical College (SMMC), United Nations Relief and Rehabilitation Administration (UNRRA) DECLARATION OF INTERESTS No conflict of interests declared. -
University of Leeds Chinese Accepted Institution List 2021
University of Leeds Chinese accepted Institution List 2021 This list applies to courses in: All Engineering and Computing courses School of Mathematics School of Education School of Politics and International Studies School of Sociology and Social Policy GPA Requirements 2:1 = 75-85% 2:2 = 70-80% Please visit https://courses.leeds.ac.uk to find out which courses require a 2:1 and a 2:2. Please note: This document is to be used as a guide only. Final decisions will be made by the University of Leeds admissions teams. -
1 Please Read These Instructions Carefully
PLEASE READ THESE INSTRUCTIONS CAREFULLY. MISTAKES IN YOUR CSC APPLICATION COULD LEAD TO YOUR APPLICATION BEING REJECTED. Visit http://studyinchina.csc.edu.cn/#/login to CREATE AN ACCOUNT. • The online application works best with Firefox or Internet Explorer (11.0). Menu selection functions may not work with other browsers. • The online application is only available in Chinese and English. 1 • Please read this page carefully before clicking on the “Application online” tab to start your application. 2 • CLIC on the Edit Personal Details button. 3 • Fill out your personal information accurately. o Make sure to have a valid passport at the time of your application. o Use the name and date of birth that are on your passport. Use the name on your passport for all correspondences with the CLIC office or Chinese institutions. o List Canadian as your Nationality, even if you have dual citizenship. Only Canadian citizens are eligible for CLIC support. o Enter the mailing address for where you want your admission documents to be sent under Permanent Address. Leave Current Address blank. o Once you have completed this section click Verify and Save. 4 • Fill out your Education and Employment History accurately. o For Highest Education enter your current degree studies. o Once you have completed this section, click Verify and Save. 5 • Provide the contact information of the host Chinese university. o The contact information for summer programs is available on the CLIC website in the Program Finder. o For exchange programs, please contact your home university international office to get your host university contact information (http://clicstudyinchina.com/contact-us/). -
Higher Education Project
Ex-ante Evaluation 1. Name of the Project Country: People’s Republic of China Project: Higher Education Project (Regional Vitalization, Market Economy Reform Support, and Environmental Conservation) (Liaoning, Hebei, and Hainan Provinces) (Loan Agreement: June 23, 2006; Loan Amount: 14,700 million yen; Borrower: The Government of the People’s Republic of China) 2. Necessity and Relevance of JBIC’s Assistance In China, the Open and Reform has since 1978 brought about the transition to a market economy, rapid economic development, and associated environmental problems. This became even truer with China’s accession to the WTO. Against this background, it is becoming necessary to strengthen education and research activities related to market rules and environmental problems. In addition, regional economic disparities have become visible, necessitating regional economic vitalization in less developed regions. Concerning these regions, improvement of higher education is also needed in terms of both quantity and quality to meet the increased demand for higher education following the spread of primary and secondary education (the higher education enrollment rate was 17% in 2003). In the “10th Five-Year Plan for National Economic and Social Development (2001-2005)” and the “10th Five-Year Plan for Education” (2001-2005), the Chinese government set goals of 15% enrollment in higher education institutions, 16 million students in higher education institutions, and human resource development in areas such as law, finance, and trade. It is assumed that even higher goals will be set in the Eleventh Five-Year Plan (2006-2010) currently being formulated. The three target provinces (Liaoning, Hebei, and Hainan) are geographically in the coastal region, but fiscal shortages have left them with comparatively lagging educational conditions. -
CONICYT Ranking Por Disciplina > Sub-Área OECD (Académicas) Comisión Nacional De Investigación 1
CONICYT Ranking por Disciplina > Sub-área OECD (Académicas) Comisión Nacional de Investigación 1. Ciencias Naturales > 1.4 Ciencias Químicas Científica y Tecnológica PAÍS INSTITUCIÓN RANKING PUNTAJE Nanyang Technological University & National Institute of Education SINGAPORE 1 5,000 (NIE) Singapore CHINA Tsinghua University 2 5,000 INDIA Indian Institute of Technology System (IIT System) 3 5,000 CHINA University of Science & Technology of China 4 5,000 CHINA Zhejiang University 5 5,000 CHINA Peking University 6 5,000 USA University of California Berkeley 7 5,000 CHINA Jilin University 8 5,000 USA Massachusetts Institute of Technology (MIT) 9 5,000 CHINA South China University of Technology 10 5,000 CHINA Suzhou University 11 5,000 USA Stanford University 12 5,000 SINGAPORE National University of Singapore 13 5,000 CHINA Nanjing University 14 5,000 CHINA Fudan University 15 5,000 SAUDI ARABIA King Abdulaziz University 16 5,000 USA University of Chicago 17 5,000 CHINA Nankai University 18 5,000 JAPAN Kyoto University 19 5,000 CHINA Shanghai Jiao Tong University 20 5,000 SWITZERLAND Ecole Polytechnique Federale de Lausanne 21 5,000 CHINA Tianjin University 22 5,000 USA Georgia Institute of Technology 23 5,000 CHINA Sichuan University 24 5,000 UNITED KINGDOM University of Cambridge 25 5,000 USA Northwestern University 26 5,000 SOUTH KOREA University of Science & Technology (UST) 27 5,000 JAPAN University of Tokyo 28 5,000 UNITED KINGDOM University of Oxford 29 5,000 CHINA Huazhong University of Science & Technology 30 5,000 CHINA Wuhan University -
Confidential: for Review Only
BMJ Confidential: For Review Only Incidence of type 1 diabetes mellitus in China: population based study, 2010 – 2013 Journal: BMJ Manuscript ID BMJ.2017.040488 Article Type: Research BMJ Journal: BMJ Date Submitted by the Author: 21-Jul-2017 Complete List of Authors: Weng, Jianping; Sun Yat-sen University Third Hospital; Guangdong Provincial Key Laboratory of Diabetology Zhou, Zhiguang; the Second Xiangya Hospital, Central South University, Institue of Endocrinology and Metabolism Guo, Lixin; Beijing Hospital Zhu, Dalong; Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital Ji, Linong; Peking University People’s Hospital, Department of Endocrinology and Metabolism Luo, Xiaoping; Tongji Hospital of Tongji Medical College, Huazhong University of Science & Technology Mu, Yiming; People’s Liberation Army General Hospital, China, Jia, Wei-Ping; The Sixth Affiliated People’s Hospital, Shanghai Jiao Tong University, YANG, WEN YING; CHINA JAPAN FRIENDSHIP HOSPITAL, ENDOCRINOLOGY Kuang, Hongyu; The First Affiliated Hospital of Harbin Medical University Li, Qiang; The Second Affiliated Hospital of Harbin Medical University, Li, Yanbing; The First Affiliated Hospital of Sun Yat-sen University Yuan, Li; Union Hospital, Tongji Medical College, Huazhong University of Science & Technology Yu, Xuefeng; Wuhan Tongji Hospital, China, Shan, Zhongyan; First Affiliated Hospital, Chinese Medical University, Ji, Qiuhe; Xijing Hospital, Fourth Military Medical University, Ran, Xing-wu; West China Hospital of Sichuan University, Diabetic