Molecules 2011, 16, 9017-9024; doi:10.3390/molecules16119017 OPEN ACCESS molecules ISSN 1420-3049 www.mdpi.com/journal/molecules Article A New Eudesmane Sesquiterpene Glucoside from Liriope muscari Fibrous Roots Hai Ming Zhang 1, Gang Li Wang 2, Chun Qi Bai 3, Peng Liu 4, Zi Mu Liu 1, Qi Zhi Liu 3, Yong Yan Wang 1, Zhi Long Liu 3,*, Shu Shan Du 1,* and Zhi Wei Deng 4 1 State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Beijing 100875, China 2 National Institutes for Food and Drug Control, Beijing 100050, China 3 Department of Entomology, China Agricultural University, Haidian District, Beijing 100193, China 4 Analytical and Testing Center, Beijing Normal University, Beijing 100875, China * Authors to whom correspondence should be addressed; E-Mails:
[email protected] (Z.L.L.);
[email protected] (S.S.D.); Tel.: +86-10-62732800; Fax: +86-10-62208032. Received: 16 September 2011; in revised form: 20 October 2011 / Accepted: 24 October 2011 / Published: 26 October 2011 Abstract: The screening of several Chinese medicinal herbs for nematocidal properties showed that the ethanol extract of Liriope muscari fibrous roots possessed significant nematocidal activity against the pine wood nematode (Bursaphelenchus xylophilus). From the ethanol extract, a new constituent (1,4-epoxy-cis-eudesm-6-O-β-D-glucopyranoside) and three known glycosides [1β,6α-dihydroxy-cis-eudesm-3-ene-6-O-β-D-glucopyranoside (liriopeoside A), 1β,6β-dihydroxy-cis-eudesm-3-ene-6-O-β-D-glucopyranoside, and 1α,6β- dihydroxy-5,10-bis-epi-eudesm-4(15)-ene-6-O-β-D-glucopyranoside] were isolated by bioassay-guided fractionation.