List of 780 probable essential proteins from host-pathogen common and pathogen’s unique pathways.

No Uniprot ID Entry name Protein names Gene names Length Associated metabolic pathways 1 O82884 O82884_ECO57 Type II secretion pathway related protein (Type II secretion protein)etpE ECO57PM03 L7034 501 Bacterial secretion system* 2 O82908 O82908_ECO57 Single-stranded DNA-binding protein ssb ECO57PM49 150 DNA replication Mismatch repair Homologous recombination 3 O85343 MANB_ECO57 Phosphomannomutase (PMM) (EC 5.4.2.8) manB Z3194 ECs2835 456 Fructose and mannose metabolism Amino sugar and nucleotide sugar metabolism 4 P0A3L9 KITH_ECO57 Thymidine kinase (EC 2.7.1.21) tdk Z2015 ECs1740 205 Pyrimidine metabolism 5 P0A4D1 RS6_ECO57 30S ribosomal protein S6 rpsF Z5809 ECs5176 131 Ribosome 6 P0A6A1 UBIB_ECO57 Probable ubiquinone biosynthesis protein UbiB ubiB aarF Z5357 ECs4765 546 Ubiquinone and other terpenoid-quinone biosynthesis 7 P0A6A5 ACKA_ECO57 Acetate kinase (EC 2.7.2.1) (Acetokinase) ackA ack Z3558 ECs3180 400 Taurine and hypotaurine metabolism Pyruvate metabolism Propanoate metabolism Methane metabolism* 8 P0A6B9 ISCS_ECO57 Cysteine desulfurase (EC 2.8.1.7) iscS Z3797 ECs3396 404 Thiamine metabolism Sulfur relay system 9 P0A6D9 AROK_ECO57 Shikimate kinase 1 (SK 1) (EC 2.7.1.71) aroK Z4743 ECs4232 173 Phenylalanine, tyrosine and tryptophan biosynthesis 10 P0A6E3 AROL_ECO57 Shikimate kinase 2 (SK 2) (EC 2.7.1.71) aroL Z0484 ECs0438 174 Phenylalanine, tyrosine and tryptophan biosynthesis 11 P0A6F2 CARA_ECO57 Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) (Carbamoyl-phosphatecarA pyrA Z0037 synthetase ECs0035 glutamine chain)382 Pyrimidine metabolism Alanine, aspartate and glutamate metabolism 12 P0A6F4 GLPK_ECO57 Glycerol kinase (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase)glpK (Glycerokinase) Z5471 ECs4851 (GK) 502 Glycerolipid metabolism 13 P0A6F7 CH60_ECO57 60 kDa chaperonin (GroEL protein) (Protein Cpn60) groL groEL mopA Z5748 ECs5124 548 RNA degradation 14 P0A6I2 KCY_ECO57 Cytidylate kinase (CK) (EC 2.7.4.25) (Cytidine monophosphate kinase)cmk mssA (CMP Z1256 kinase) ECs0993 227 Pyrimidine metabolism 15 P0A6I5 COAA_ECO57 Pantothenate kinase (EC 2.7.1.33) (Pantothenic acid kinase) coaA panK rts Z5545 ECs4901 316 Pantothenate and CoA biosynthesis 16 P0A6I7 COAD_ECO57 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) (Dephospho-CoAcoaD kdtBpyrophosphorylase) Z5058 ECs4509 (Pantetheine-phosphate159 Pantothenate adenylyltransferase) and CoA biosynthesis (PPAT) 17 P0A6J0 COAE_ECO57 Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase)coaE Z0113 ECs0107 206 Pantothenate and CoA biosynthesis 18 P0A6J2 CYSC_ECO57 Adenylyl-sulfate kinase (EC 2.7.1.25) (APS kinase) (ATP adenosine-5'-phosphosulfatecysC Z4058 ECs3604 3'-phosphotransferase)201 Purine(Adenosine-5'-phosphosulfate metabolism kinase) Sulfur metabolism 19 P0A6J7 DADA_ECO57 D-amino acid dehydrogenase small subunit (EC 1.4.99.1) dadA dadR Z1952 ECs1684 432 Phenylalanine metabolism 20 P0A6J9 DDLA_ECO57 D-alanine--D-alanine ligase A (EC 6.3.2.4) (D-Ala-D-Ala ligase A)ddlA (D-alanylalanine Z0477 ECs0431 synthetase A) 364 D-Alanine metabolism* Peptidoglycan biosynthesis* 21 P0A6K2 DAPF_ECO57 Diaminopimelate epimerase (DAP epimerase) (EC 5.1.1.7) dapF Z5326 ECs4739 274 Lysine biosynthesis 22 P0A6K8 DEOB_ECO57 Phosphopentomutase (EC 5.4.2.7) (Phosphodeoxyribomutase) deoB drm thyR Z5985 ECs5342 407 Pentose phosphate pathway Purine metabolism 23 P0A6Q1 ENO_ECO57 Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerateeno Z4094 ECs3639 dehydratase) 432 Glycolysis / Gluconeogenesis RNA degradation Methane metabolism* 24 P0A6Q4 FABA_ECO57 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.60)fabA (Beta-hydroxydecanoyl Z1304 ECs1038 thioester dehydrase)172 Fatty acid biosynthesis 25 P0A6Q8 FABZ_ECO57 (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase ((3R)-hydroxymyristoylfabZ Z0192 ECs0182 ACP dehydrase) (EC 4.2.1.-)151 Fatty acid biosynthesis 26 P0A6R2 FABH_ECO57 3-oxoacyl-[acyl-carrier-protein] synthase 3 (EC 2.3.1.180) (3-oxoacyl-[acyl-carrier-protein]fabH Z1730 ECs1469 synthase III) (Beta-ketoacyl-ACP317 Fatty acid biosynthesis synthase III) (KAS III) (EcFabH) 27 P0A6S9 GPDA_ECO57 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) (NAD(P)H-dependentgpsA Z5035 ECs4486 glycerol-3-phosphate339 dehydrogenase)Glycerophospholipid metabolism 28 P0A6T2 G6PI_ECO57 Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Phosphoglucosepgi isomerase)Z5623 ECs5008 (PGI) (Phosphohexose isomerase)549 Glycolysis (PHI) / Gluconeogenesis Pentose phosphate pathway Starch and sucrose metabolism Amino sugar and nucleotide sugar metabolism 29 P0A6T7 GCH1_ECO57 GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (GTP-CH-I)folE Z3409 ECs3045 222 Folate biosynthesis 30 P0A6V3 GLGC_ECO57 Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) (ADP-glucoseglgC pyrophosphorylase)Z4792 ECs4275 (ADPGlc PPase)431 (ADP-glucoseStarch and sucrose synthase) metabolism Amino sugar and nucleotide sugar metabolism 31 P0A6X2 HEM1_ECO57 Glutamyl-tRNA reductase (GluTR) (EC 1.2.1.70) hemA Z1981 ECs1715 418 Porphyrin and chlorophyll metabolism 32 P0A6X5 HFQ_ECO57 Protein hfq (HF-1) (Host factor-I protein) (HF-I) hfq Z5779 ECs5148 102 RNA degradation 33 P0A6Z0 DNAK_ECO57 Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (HeatdnaK shock Z0014 protein ECs0014 70) 638 RNA degradation 34 P0A719 KPRS_ECO57 Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (Phosphoribosylprs prsA Z1978 pyrophosphate ECs1712 synthase) (P-Rib-PP315 Pentose synthase) phosphate (PRPP pathway synthase) Purine metabolism 35 P0A727 LPXC_ECO57 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylaselpxC (EC Z01063.5.1.-) ECs0100 (UDP-3-O-acyl-GlcNAc deacetylase)305 Lipopolysaccharide biosynthesis* 36 P0A732 MGSA_ECO57 Methylglyoxal synthase (MGS) (EC 4.2.3.3) mgsA Z1314 ECs1047 152 Pyruvate metabolism 37 P0A740 MOAC_ECO57 Molybdenum cofactor biosynthesis protein C moaC chlA3 Z1002 ECs0861 161 Folate biosynthesis Sulfur relay system 38 P0A760 NAGB_ECO57 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) (GlcN6P deaminase)nagB glmD (GNPDA) Z0825 (Glucosamine-6-phosphateECs0708 266 Amino isomerase) sugar and nucleotide sugar metabolism 39 P0A764 NDK_ECO57 Nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6)ndk (Nucleoside-2-P Z3781 ECs3380 kinase) 143 Purine metabolism Pyrimidine metabolism 40 P0A778 RPPH_ECO57 RNA pyrophosphohydrolase (EC 3.6.1.-) ((Di)nucleoside polyphosphaterppH nudH hydrolase) Z4147 ECs3687 176 RNA degradation 41 P0A795 PDXJ_ECO57 Pyridoxine 5'-phosphate synthase (PNP synthase) (EC 2.6.99.2) pdxJ Z3845 ECs3430 243 Vitamin B6 metabolism 42 P0A797 K6PF1_ECO57 6-phosphofructokinase isozyme 1 (EC 2.7.1.11) (6-phosphofructokinasepfkA Z5460 isozyme ECs4841 I) (Phosphofructokinase320 1) (PhosphohexokinaseGlycolysis / Gluconeogenesis 1) Pentose phosphate pathway Fructose and mannose metabolism Galactose metabolism Methane metabolism* 43 P0A7A3 GPMB_ECO57 Probable phosphoglycerate mutase GpmB (EC 5.4.2.1) (PGAM) (Phosphoglyceromutase)gpmB Z5997 ECs5353 215 Glycine, serine and threonine metabolism 44 P0A7B0 IPYR_ECO57 Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase)ppa Z5837 ECs5204(PPase) 176 Oxidative phosphorylation 45 P0A7B7 PROB_ECO57 Glutamate 5-kinase (EC 2.7.2.11) (Gamma-glutamyl kinase) (GK)proB Z0303 ECs0269 367 Arginine and proline metabolism 46 P0A7D6 PURA_ECO57 Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartatepurA Z5784 ECs5153 ligase) 432 Purine metabolism Alanine, aspartate and glutamate metabolism 47 P0A7D9 PUR7_ECO57 Phosphoribosylaminoimidazole-succinocarboxamide synthase (ECpurC 6.3.2.6) Z3735 (SAICAR ECs3338 synthetase) 237 Purine metabolism 48 P0A7E2 PYRD_ECO57 Dihydroorotate dehydrogenase (quinone) (EC 1.3.5.2) (DHOdehase)pyrD (DHOD) Z1294 ECs1029(DHODase) (Dihydroorotate336 oxidase)Pyrimidine metabolism 49 P0A7E7 PYRG_ECO57 CTP synthase (EC 6.3.4.2) (CTP synthetase) (UTP--ammonia ligase)pyrG Z4095 ECs3640 545 Pyrimidine metabolism 50 P0A7F1 PYRH_ECO57 Uridylate kinase (UK) (EC 2.7.4.22) (Uridine monophosphate kinase)pyrH (UMP Z0182 kinase) ECs0173 (UMPK) 241 Pyrimidine metabolism 51 P0A7F5 PYRI_ECO57 Aspartate carbamoyltransferase regulatory chain pyrI Z5855 ECs5221 153 Pyrimidine metabolism Alanine, aspartate and glutamate metabolism 52 P0A7G8 RECA_ECO57 Protein RecA (Recombinase A) recA Z4002 ECs3556 353 Homologous recombination 53 P0A7H2 RECF_ECO57 DNA replication and repair protein RecF recF uvrF Z5191 ECs4635 357 Homologous recombination 54 P0A7I8 RIBA_ECO57 GTP cyclohydrolase-2 (EC 3.5.4.25) (GTP cyclohydrolase II) ribA Z2531 ECs1850 196 Riboflavin metabolism 55 P0A7J1 RIBB_ECO57 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase)ribB (EC htrP 4.1.99.12) Z4399 ECs3929 217 Riboflavin metabolism 56 P0A7J5 RL10_ECO57 50S ribosomal protein L10 rplJ Z5558 ECs4908 165 Ribosome 57 P0A7J9 RL11_ECO57 50S ribosomal protein L11 rplK Z5556 ECs4906 142 Ribosome 58 P0A7K4 RL7_ECO57 50S ribosomal protein L7/L12 (L8) rplL Z5559 ECs4909 121 Ribosome 59 P0A7K8 RL19_ECO57 50S ribosomal protein L19 rplS Z3900 ECs3469 115 Ribosome 60 P0A7L2 RL1_ECO57 50S ribosomal protein L1 rplA Z5557 ECs4907 234 Ribosome 61 P0A7L5 RL20_ECO57 50S ribosomal protein L20 rplT Z2745 ECs2423 118 Ribosome 62 P0A7M0 RL27_ECO57 50S ribosomal protein L27 rpmA Z4547 ECs4064 85 Ribosome 63 P0A7M4 RL28_ECO57 50S ribosomal protein L28 rpmB Z5061 ECs4512 78 Ribosome 64 P0A7M8 RL29_ECO57 50S ribosomal protein L29 rpmC Z4683 ECs4177 63 Ribosome 65 P0A7N0 RL31_ECO57 50S ribosomal protein L31 rpmE Z5484 ECs4863 70 Ribosome 66 P0A7Q2 RL35_ECO57 50S ribosomal protein L35 rpmI Z2746 ECs2424 65 Ribosome 67 P0A7R3 RL9_ECO57 50S ribosomal protein L9 rplI Z5812 ECs5179 149 Ribosome 68 P0A7R7 RS10_ECO57 30S ribosomal protein S10 rpsJ nusE Z4692 ECs4186 103 Ribosome 69 P0A7S1 RS11_ECO57 30S ribosomal protein S11 rpsK Z4667 ECs4162 129 Ribosome 70 P0A7S5 RS12_ECO57 30S ribosomal protein S12 rpsL strA Z4700 ECs4193 124 Ribosome 71 P0A7T1 RS13_ECO57 30S ribosomal protein S13 rpsM Z4668 ECs4163 118 Ribosome 72 P0A7T5 RS16_ECO57 30S ribosomal protein S16 rpsP Z3903 ECs3472 82 Ribosome 73 P0A7T9 RS18_ECO57 30S ribosomal protein S18 rpsR Z5811 ECs5178 75 Ribosome 74 P0A7U5 RS19_ECO57 30S ribosomal protein S19 rpsS Z4687 ECs4181 92 Ribosome 75 P0A7U9 RS20_ECO57 30S ribosomal protein S20 rpsT Z0027 ECs0026 87 Ribosome 76 P0A7V2 RS2_ECO57 30S ribosomal protein S2 rpsB Z0180 ECs0171 241 Ribosome 77 P0A7V5 RS3_ECO57 30S ribosomal protein S3 rpsC Z4685 ECs4179 233 Ribosome 78 P0A7W0 RS4_ECO57 30S ribosomal protein S4 rpsD ramA Z4666 ECs4161 206 Ribosome 79 P0A7W3 RS5_ECO57 30S ribosomal protein S5 rpsE Z4673 ECs4168 167 Ribosome 80 P0A7W9 RS8_ECO57 30S ribosomal protein S8 rpsH Z4676 ECs4171 130 Ribosome 81 P0A7X5 RS9_ECO57 30S ribosomal protein S9 rpsI Z4588 ECs4103 130 Ribosome 82 P0A7Y6 RNH_ECO57 Ribonuclease HI (RNase HI) (EC 3.1.26.4) rnhA Z0239 ECs0210 155 DNA replication 83 P0A7Z2 RPIA_ECO57 Ribose-5-phosphate isomerase A (EC 5.3.1.6) (PhosphoriboisomeraserpiA A)Z4252 (PRI) ECs3785 219 Pentose phosphate pathway 84 P0A7Z6 RPOA_ECO57 DNA-directed RNA polymerase subunit alpha (RNAP subunit alpha)rpoA (EC Z4665 2.7.7.6) ECs4160 (RNA polymerase subunit329 alpha)Purine (Transcriptase metabolism subunit alpha) Pyrimidine metabolism 85 P0A7Z6 RPOA_ECO57 DNA-directed RNA polymerase subunit alpha (RNAP subunit alpha)rpoA (EC Z4665 2.7.7.6) ECs4160 (RNA polymerase subunit329 alpha)RNA polymerase(Transcriptase subunit alpha) 86 P0A802 RPOZ_ECO57 DNA-directed RNA polymerase subunit omega (RNAP omega subunit)rpoZ Z5075 (EC 2.7.7.6) ECs4524 (RNA polymerase omega91 Purine subunit) metabolism (Transcriptase subunit omega) Pyrimidine metabolism RNA polymerase 87 P0A811 RUVA_ECO57 Holliday junction ATP-dependent DNA helicase RuvA (EC 3.6.4.12)ruvA Z2913 ECs2571 203 Homologous recombination 88 P0A813 RUVB_ECO57 Holliday junction ATP-dependent DNA helicase RuvB (EC 3.6.4.12)ruvB Z2912 ECs2570 336 Homologous recombination 89 P0A816 RUVC_ECO57 Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4) (HollidayruvC Z2915 junction ECs2573 nuclease RuvC) (Holliday173 junctionHomologous resolvase recombination RuvC) 90 P0A819 METK_ECO57 S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (MAT)metK Z4287(Methionine ECs3818 adenosyltransferase)384 Cysteine and methionine metabolism 91 P0A838 SUCC_ECO57 Succinyl-CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoAsucC Z0882 ECs0753synthetase subunit beta) (SCS-beta)388 Citrate cycle (TCA cycle) Propanoate metabolism C5-Branched dibasic acid metabolism* 92 P0A860 TPIS_ECO57 Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Triose-phosphate tpiAisomerase) tpi Z5464 ECs4844 255 Glycolysis / Gluconeogenesis Fructose and mannose metabolism Inositol phosphate metabolism 93 P0A886 TYSY_ECO57 Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) thyA Z4144 ECs3684 264 Pyrimidine metabolism One carbon pool by folate 94 P0A888 UBIE_ECO57 Ubiquinone/menaquinone biosynthesis methyltransferase ubiE (ECubiE 2.1.1.163) Z5355 ECs4763(EC 2.1.1.201) (2-methoxy-6-polyprenyl-1,4-benzoquinol251 Ubiquinone and other terpenoid-quinone methylase) (Demethylmenaquinone biosynthesis methyltransferase) 95 P0A892 TUSA_ECO57 Sulfurtransferase TusA (EC 2.8.1.-) (tRNA 2-thiouridine synthesizingtusA protein Z4844 A)ECs4319 81 Sulfur relay system 96 P0A8F2 UPP_ECO57 Uracil phosphoribosyltransferase (EC 2.4.2.9) (UMP pyrophosphorylase)upp Z3761 (UPRTase) ECs3360 208 Pyrimidine metabolism 97 P0A8F6 URK_ECO57 Uridine kinase (EC 2.7.1.48) (Cytidine monophosphokinase) (Uridineudk Z3234monophosphokinase) ECs2873 213 Pyrimidine metabolism 98 P0A8F9 UVRB_ECO57 UvrABC system protein B (Protein UvrB) (Excinuclease ABC subunituvrB B)Z0998 ECs0857 673 Nucleotide excision repair 99 P0A8K3 PSD_ECO57 Phosphatidylserine decarboxylase proenzyme (EC 4.1.1.65) [Cleavedpsd Z5766into: Phosphatidylserine ECs5139 decarboxylase322 alphaGlycerophospholipid chain; Phosphatidylserine metabolism decarboxylase beta chain] 100 P0A8L3 SYS_ECO57 Serine--tRNA ligase (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS)serS (Seryl-tRNA(Ser/Sec) Z1239 ECs0978 synthetase) 430 Aminoacyl-tRNA biosynthesis 101 P0A8N6 SYK2_ECO57 Lysine--tRNA ligase, heat inducible (EC 6.1.1.6) (Lysyl-tRNA synthetase)lysU Z5732 (LysRS) ECs5111 505 Aminoacyl-tRNA biosynthesis 102 P0A8N9 YJEA_ECO57 Uncharacterized protein YjeA yjeA Z5763 ECs5136 325 Aminoacyl-tRNA biosynthesis 103 P0A8Q4 FRDD_ECO57 Fumarate reductase subunit D (Fumarate reductase 13 kDa hydrophobicfrdD Z5758 protein) ECs5132 119 Citrate cycle (TCA cycle) Oxidative phosphorylation Butanoate metabolism Toluene degradation* Two-component system* 104 P0A8T8 RPOC_ECO57 DNA-directed RNA polymerase subunit beta' (RNAP subunit beta')rpoC (EC Z5561 2.7.7.6) ECs4911 (RNA polymerase subunit1407 beta')Purine (Transcriptase metabolism subunit beta') Pyrimidine metabolism RNA polymerase 105 P0A8V4 RPOB_ECO57 DNA-directed RNA polymerase subunit beta (RNAP subunit beta)rpoB (EC Z55602.7.7.6) ECs4910 (RNA polymerase subunit1342 beta)Purine (Transcriptase metabolism subunit beta) Pyrimidine metabolism RNA polymerase 106 P0A966 CHEW_ECO57 Chemotaxis protein CheW cheW Z2941 ECs2597 167 Two-component system* Bacterial chemotaxis* 107 P0A990 DPO3B_ECO57 DNA polymerase III subunit beta (EC 2.7.7.7) dnaN Z5192 ECs4636 366 Purine metabolism Pyrimidine metabolism DNA replication Mismatch repair Homologous recombination 108 P0A9B4 G3P1_ECO57 Glyceraldehyde-3-phosphate dehydrogenase A (GAPDH-A) (EC 1.2.1.12)gapA Z2818 ECs2488 331 Glycolysis / Gluconeogenesis 109 P0A9B8 E4PD_ECO57 D-erythrose-4-phosphate dehydrogenase (E4PDH) (EC 1.2.1.72) epd Z4266 ECs3798 339 Vitamin B6 metabolism 110 P0A9C1 GLPA_ECO57 Anaerobic glycerol-3-phosphate dehydrogenase subunit A (G-3-P glpAdehydrogenase) Z3499 ECs3126 (EC 1.1.5.3) 542 Glycerophospholipid metabolism 111 P0A9C7 GLNA_ECO57 Glutamine synthetase (EC 6.3.1.2) (Glutamate--ammonia ligase) glnA Z5406 ECs4792 469 Alanine, aspartate and glutamate metabolism Arginine and proline metabolism Glyoxylate and dicarboxylate metabolism Nitrogen metabolism* Two-component system* 112 P0A9D6 CYSE_ECO57 Serine acetyltransferase (SAT) (EC 2.3.1.30) cysE Z5034 ECs4485 273 Cysteine and methionine metabolism Sulfur metabolism 113 P0A9J9 PHEA_ECO57 P-protein [Includes: Chorismate mutase (CM) (EC 5.4.99.5); PrephenatepheA Z3891 dehydratase ECs3462 (PDT) (EC 4.2.1.51)]386 Phenylalanine, tyrosine and tryptophan biosynthesis 114 P0A9M6 XGPT_ECO57 Xanthine phosphoribosyltransferase (EC 2.4.2.22) (Xanthine-guaninegpt Z0299phosphoribosyltransferase) ECs0265 (XGPRT)152 Purine metabolism 115 P0A9P2 DLDH_ECO57 Dihydrolipoyl dehydrogenase (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase)lpdA Z0126 ECs0120 (E3 component of pyruvate474 andGlycolysis 2-oxoglutarate / Gluconeogenesis dehydrogenases complexes) (Glycine cleavage system L protein) Citrate cycle (TCA cycle) Glycine, serine and threonine metabolism Valine, leucine and isoleucine degradation Pyruvate metabolism 116 P0A9P5 TRXB_ECO57 Thioredoxin reductase (TRXR) (EC 1.8.1.9) trxB Z1232 ECs0973 321 Pyrimidine metabolism Selenocompound metabolism 117 P0A9Q3 ARCA_ECO57 Aerobic respiration control protein ArcA arcA Z6004 ECs5359 238 Two-component system* 118 P0A9Q6 ACCD_ECO57 Acetyl-coenzyme A carboxylase carboxyl transferase subunit betaaccD (ACCase Z3578 subunit ECs3200 beta) (Acetyl-CoA carboxylase304 Fatty carboxyltransferaseacid biosynthesis subunit beta) (EC 6.4.1.2) Pyruvate metabolism Propanoate metabolism 119 P0A9Q8 ADHE_ECO57 Aldehyde-alcohol dehydrogenase [Includes: Alcohol dehydrogenaseadhE (ADH) Z2016 (EC ECs1741 1.1.1.1); Acetaldehyde dehydrogenase891 Glycolysis [acetylating] / Gluconeogenesis (ACDH) (EC 1.2.1.10); Pyruvate-formate-lyase deactivase (PFL deactivase)] Fatty acid metabolism Tyrosine metabolism Pyruvate metabolism Butanoate metabolism Benzoate degradation* Dioxin degradation* Xylene degradation* Chloroalkane and chloroalkene degradation* Naphthalene degradation* Nitrotoluene degradation* 120 P0A9R0 DHAS_ECO57 Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (ASADH)asd Z4797 (EC ECs4278 1.2.1.11) (Aspartate-beta-semialdehyde367 Glycine, dehydrogenase) serine and threonine metabolism Cysteine and methionine metabolism Lysine biosynthesis 121 P0A9R9 FTSE_ECO57 Cell division ATP-binding protein FtsE ftsE Z4837 ECs4312 222 ABC transporters 122 P0A9S2 FUCO_ECO57 Lactaldehyde reductase (EC 1.1.1.77) (Propanediol oxidoreductase)fucO Z4116 ECs3659 382 Pyruvate metabolism Glyoxylate and dicarboxylate metabolism 123 P0A9S4 GATD_ECO57 Galactitol-1-phosphate 5-dehydrogenase (EC 1.1.1.251) gatD Z3254 ECs2894 346 Galactose metabolism 124 P0A9T2 SERA_ECO57 D-3-phosphoglycerate dehydrogenase (PGDH) (EC 1.1.1.95) serA Z4251 ECs3784 410 Glycine, serine and threonine metabolism Methane metabolism* 125 P0A9V3 LPTB_ECO57 Lipopolysaccharide export system ATP-binding protein LptB (EC lptB3.6.3.-) Z4564 ECs4080 241 ABC transporters 126 P0A9Z3 GLNB_ECO57 Nitrogen regulatory protein P-II 1 glnB Z3829 ECs3419 112 Two-component system* 127 P0AA06 PTHP_ECO57 Phosphocarrier protein HPr (EC 2.7.11.-) (Histidine-containing protein)ptsH Z3681 ECs3287 85 Phosphotransferase system* 128 P0AA12 RL13_ECO57 50S ribosomal protein L13 rplM Z4589 ECs4104 142 Ribosome 129 P0AA18 OMPR_ECO57 Transcriptional regulatory protein OmpR ompR Z4760 ECs4247 239 Two-component system* 130 P0AAB0 ZRAP_ECO57 Zinc resistance-associated protein zraP Z5578 ECs4925 141 Two-component system* 131 P0AAB7 GALF_ECO57 UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (Alpha-D-glucosyl-1-phosphategalF wcaN Z3205 ECs2846 uridylyltransferase)297 Pentose (UDP-glucose and glucuronate pyrophosphorylase) interconversions (UDPGP) (Uridine diphosphoglucose pyrophosphorylase) Galactose metabolism Starch and sucrose metabolism Amino sugar and nucleotide sugar metabolism 132 P0AAF5 ARAG_ECO57 Arabinose import ATP-binding protein AraG (EC 3.6.3.17) araG Z2953 ECs2608 504 ABC transporters 133 P0AAF8 ARTP_ECO57 Arginine transport ATP-binding protein ArtP (EC 3.6.3.-) artP Z1094 ECs0947 242 ABC transporters 134 P0AAG1 DPPD_ECO57 Dipeptide transport ATP-binding protein DppD dppD Z4958 ECs4421 327 ABC transporters 135 P0AAG4 GLTL_ECO57 Glutamate/aspartate transport ATP-binding protein GltL gltL Z0802 ECs0691 241 ABC transporters 136 P0AAI2 SSUB_ECO57 Aliphatic sulfonates import ATP-binding protein SsuB (EC 3.6.3.-)ssuB Z1281 ECs1016 255 ABC transporters 137 P0AAI7 FABF_ECO57 3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC 2.3.1.179) (3-oxoacyl-[acyl-carrier-protein]fabF Z1734 ECs1473 synthase II) (Beta-ketoacyl-ACP413 Fatty acid biosynthesis synthase II) (KAS II) 138 P0AAK8 NRFC_ECO57 Protein nrfC nrfC Z5671 ECs5054 223 Nitrogen metabolism* 139 P0AB72 ALF_ECO57 Fructose-bisphosphate aldolase class 2 (FBP aldolase) (FBPA) (ECfbaA 4.1.2.13) Z4263 (Fructose-1,6-bisphosphate ECs3796 aldolase)359 Glycolysis (Fructose-bisphosphate / Gluconeogenesis aldolase class II) Pentose phosphate pathway Fructose and mannose metabolism Methane metabolism* 140 P0AB76 KBAY_ECO57 D-tagatose-1,6-bisphosphate aldolase subunit KbaY (TBPA) (TagBPkbaY aldolase) agaY Z4491 (EC 4.1.2.40) ECs4017 (D-tagatose-bisphosphate286 Galactose aldolase metabolism class II) (Ketose 1,6-bisphosphate aldolase class II) (Tagatose-bisphosphate aldolase) 141 P0AB82 ILVE_ECO57 Branched-chain-amino-acid aminotransferase (BCAT) (EC 2.6.1.42)ilvE (Transaminase Z5281 ECs4704 B) 309 Valine, leucine and isoleucine degradation Valine, leucine and isoleucine biosynthesis Pantothenate and CoA biosynthesis 142 P0AB92 AROG_ECO57 Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive (ECaroG 2.5.1.54) Z0924 (3-deoxy-D-arabino-heptulosonate ECs0782 350 Phenylalanine, 7-phosphate synthase) tyrosine and(DAHP tryptophan synthase) biosynthesis (Phospho-2-keto-3-deoxyheptonate aldolase) 143 P0AB99 ATP6_ECO57 ATP synthase subunit a (ATP synthase F0 sector subunit a) (F-ATPaseatpB subunitZ5236 ECs46806) 271 Oxidative phosphorylation 144 P0ABA2 ATPF_ECO57 ATP synthase subunit b (ATP synthase F(0) sector subunit b) (ATPaseatpF subunitZ5234 ECs4678I) (F-type ATPase subunit b)156 (F-ATPaseOxidative subunit phosphorylation b) 145 P0ABA5 ATPD_ECO57 ATP synthase subunit delta (ATP synthase F(1) sector subunit delta)atpH (F-type Z5233 ATPase ECs4677 subunit delta) (F-ATPase177 subunitOxidative delta) phosphorylation 146 P0ABA8 ATPG_ECO57 ATP synthase gamma chain (ATP synthase F1 sector gamma subunit)atpG (F-ATPase Z5231 ECs4675 gamma subunit) 287 Oxidative phosphorylation 147 P0ABB2 ATPA_ECO57 ATP synthase subunit alpha (EC 3.6.3.14) (ATP synthase F1 sectoratpA subunit Z5232 alpha) ECs4676 (F-ATPase subunit alpha)513 Oxidative phosphorylation 148 P0ABB6 ATPB_ECO57 ATP synthase subunit beta (EC 3.6.3.14) (ATP synthase F1 sector atpDsubunit Z5230 beta) ECs4674 (F-ATPase subunit beta) 460 Oxidative phosphorylation 149 P0ABD6 ACCA_ECO57 Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaaccA (ACCase Z0197 subunit ECs0187 alpha) (Acetyl-CoA 319carboxylaseFatty acid carboxyltransferase biosynthesis subunit alpha) (EC 6.4.1.2) Pyruvate metabolism Propanoate metabolism 150 P0ABE0 BCCP_ECO57 Biotin carboxyl carrier protein of acetyl-CoA carboxylase (BCCP)accB Z4615 ECs4127 156 Fatty acid biosynthesis Pyruvate metabolism Propanoate metabolism 151 P0ABF3 PCNB_ECO57 Poly(A) polymerase (PAP) (EC 2.7.7.19) (Plasmid copy number protein)pcnB Z0154 ECs0147 465 RNA degradation 152 P0ABG0 PGSA_ECO57 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferasepgsA (EC Z3000 2.7.8.5) ECs2650 (Phosphatidylglycerophosphate182 Glycerophospholipid synthase) (PGP synthase) metabolism 153 P0ABG2 CDSA_ECO57 Phosphatidate cytidylyltransferase (EC 2.7.7.41) (CDP-DAG synthase)cdsA Z0186(CDP-DG ECs0177 synthase) (CDP-diacylglycerol285 Glycerophospholipid synthase) (CDS) (CDP-diglyceride metabolism pyrophosphorylase) (CDP-diglyceride synthase) (CTP:phosphatidate cytidylyltransferase) 154 P0ABJ0 CYOB_ECO57 Ubiquinol oxidase subunit 1 (EC 1.10.3.-) (Cytochrome o subunit cyoB1) (Cytochrome Z0534 ECs0485 o ubiquinol oxidase subunit663 Oxidative 1) (Oxidase phosphorylation BO(3) subunit 1) (Ubiquinol oxidase chain A) (Ubiquinol oxidase polypeptide I) 155 P0ABJ7 CYOD_ECO57 Cytochrome o ubiquinol oxidase protein CyoD (Ubiquinol oxidasecyoD chain Z0532 D) ECs0483 109 Oxidative phosphorylation 156 P0ABK4 CYDB_ECO57 Cytochrome d ubiquinol oxidase subunit 2 (EC 1.10.3.-) (CytochromecydB bd-I Z0901 oxidase ECs0769 subunit II) (Cytochrome379 d Oxidativeubiquinol oxidasephosphorylation subunit II) Two-component system* 157 P0ABL0 NRFA_ECO57 Cytochrome c-552 (EC 1.7.2.2) (Ammonia-forming cytochrome cnrfA nitrite Z5669 reductase) ECs5052 (Cytochrome c nitrite 478reductase)Nitrogen metabolism* 158 P0ABM3 CCMC_ECO57 Heme exporter protein C (Cytochrome c-type biogenesis protein CcmC)ccmC Z3456 ECs3088 245 ABC transporters 159 P0ABN3 KDGL_ECO57 Diacylglycerol kinase (DAGK) (EC 2.7.1.107) (Diglyceride kinase)dgkA (DGK) Z5641 ECs5025 122 Glycerolipid metabolism Glycerophospholipid metabolism 160 P0ABP9 DEOD_ECO57 Purine nucleoside phosphorylase DeoD-type (PNP) (EC 2.4.2.1) deoD Z5986 ECs5343 239 Purine metabolism Pyrimidine metabolism Nicotinate and nicotinamide metabolism 161 P0ABS6 PRIM_ECO57 DNA primase (EC 2.7.7.-) dnaG Z4419 ECs3949 581 DNA replication 162 P0ABW1 HCAC_ECO57 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunithcaC (Digoxigenin Z3811 ECs3406 ferredoxin subunit) 106 Phenylalanine metabolism Dioxin degradation* 163 P0ABZ5 KDSC_ECO57 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC (ECkdsC 3.1.3.45) Z4561 ECs4077(KDO 8-P phosphatase) 188 Lipopolysaccharide biosynthesis* 164 P0AC43 DHSA_ECO57 Succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) sdhA Z0877 ECs0748 588 Citrate cycle (TCA cycle) Oxidative phosphorylation Butanoate metabolism Toluene degradation* 165 P0AC49 FRDB_ECO57 Fumarate reductase iron-sulfur subunit (EC 1.3.99.1) frdB Z5760 ECs5134 244 Citrate cycle (TCA cycle) Oxidative phosphorylation Butanoate metabolism Toluene degradation* Two-component system* 166 P0AC77 KDTA_ECO57 3-deoxy-D-manno-octulosonic-acid transferase (EC 2.4.-.-) (KDOwaaA transferase) kdtA Z5057 ECs4508 425 Lipopolysaccharide biosynthesis* 167 P0ACB6 HEMG_ECO57 Protoporphyrinogen IX dehydrogenase [menaquinone] (EC 1.3.5.3)hemG Z5372 ECs4778 181 Porphyrin and chlorophyll metabolism 168 P0ACC8 GLMU_ECO57 Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine glmUpyrophosphorylase Z5228 ECs4672 (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate456 Amino sugar and nucleotide uridyltransferase); sugar metabolism Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)] 169 P0ACV1 HTRB_ECO57 Lipid A biosynthesis lauroyl acyltransferase (EC 2.3.1.-) (Heat shockhtrB protein waaM B)Z1690 ECs1432 306 Lipopolysaccharide biosynthesis* 170 P0AD00 CUSR_ECO57 Transcriptional regulatory protein CusR cusR Z0709 ECs0609 227 Two-component system* 171 P0AD62 KPYK1_ECO57 Pyruvate kinase I (EC 2.7.1.40) (PK-1) pykF Z2704 ECs2383 470 Glycolysis / Gluconeogenesis Purine metabolism Pyruvate metabolism 172 P0AD67 PBP2_ECO57 Penicillin-binding protein 2 (PBP-2) mrdA pbpA Z0781 ECs0673 633 Peptidoglycan biosynthesis* 173 P0AD69 FTSI_ECO57 Peptidoglycan synthase FtsI (EC 2.4.1.129) (Penicillin-binding proteinftsI pbpB 3) (PBP-3) Z0094 (PeptidoglycanECs0088 glycosyltransferase588 Peptidoglycan 3) biosynthesis* 174 P0ADC5 LOLC_ECO57 Lipoprotein-releasing system transmembrane protein LolC lolC Z1757 ECs1494 399 ABC transporters 175 P0ADG6 SUHB_ECO57 Inositol-1-monophosphatase (I-1-Pase) (IMPase) (Inositol-1-phosphatase)suhB Z3800 (EC ECs33993.1.3.25) 267 Inositol phosphate metabolism Streptomycin biosynthesis* 176 P0ADG8 IMDH_ECO57 Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPD)guaB Z3772 (IMPDH) ECs3370 (EC 1.1.1.205) 488 Purine metabolism 177 P0ADY5 RL14_ECO57 50S ribosomal protein L14 rplN Z4680 ECs4175 123 Ribosome 178 P0ADY9 RL16_ECO57 50S ribosomal protein L16 rplP Z4684 ECs4178 136 Ribosome 179 P0ADZ2 RL23_ECO57 50S ribosomal protein L23 rplW Z4689 ECs4183 100 Ribosome 180 P0ADZ9 YAJC_ECO57 UPF0092 membrane protein YajC yajC Z0506 ECs0458 110 Protein export Bacterial secretion system* 181 P0AE38 ASTA_ECO57 Arginine N-succinyltransferase (AST) (EC 2.3.1.109) (AOST) astA Z2779 ECs2453 344 Arginine and proline metabolism 182 P0AE68 CHEY_ECO57 Chemotaxis protein CheY cheY Z2936 ECs2592 129 Two-component system* Bacterial chemotaxis* 183 P0AE75 CITT_ECO57 Citrate carrier (Citrate transporter) (Citrate/succinate antiporter) citT Z0756 ECs0651 487 Two-component system* 184 P0AEA9 CYSG_ECO57 Siroheme synthase [Includes: Uroporphyrinogen-III C-methyltransferasecysG Z4729 (Urogen ECs4219 III methylase) (EC 2.1.1.107)457 Porphyrin (SUMT) and (Uroporphyrinogen chlorophyll metabolism III methylase) (UROM); Precorrin-2 dehydrogenase (EC 1.3.1.76); Sirohydrochlorin ferrochelatase (EC 4.99.1.4)] 185 P0AEE0 DCM_ECO57 DNA-cytosine methyltransferase (EC 2.1.1.37) dcm Z3054 ECs2699 472 Cysteine and methionine metabolism 186 P0AEE9 DMA_ECO57 DNA adenine methylase (EC 2.1.1.72) (DNA adenine methyltransferase)dam Z4740 (Deoxyadenosyl-methyltransferase) ECs4229 278 Mismatch repair 187 P0AEG3 DPPC_ECO57 Dipeptide transport system permease protein dppC dppC Z4959 ECs4422 300 ABC transporters 188 P0AEK5 FABI_ECO57 Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (ENR) (EC 1.3.1.9)fabI Z2512 (NADH-dependent ECs1861 enoyl-ACP reductase)262 Fatty acid biosynthesis 189 P0AEP5 GALU_ECO57 UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (Alpha-D-glucosyl-1-phosphategalU Z2012 ECs1738 uridylyltransferase)302 Pentose (UDP-glucose and glucuronate pyrophosphorylase) interconversions (UDPGP) (Uridine diphosphoglucose pyrophosphorylase) Galactose metabolism Starch and sucrose metabolism Amino sugar and nucleotide sugar metabolism 190 P0AEP8 GCL_ECO57 Glyoxylate carboligase (EC 4.1.1.47) (Tartronate-semialdehyde synthase)gcl Z0661 ECs0568 593 Glyoxylate and dicarboxylate metabolism 191 P0AEQ8 GLNP_ECO57 Glutamine transport system permease protein glnP glnP Z1032 ECs0888 219 ABC transporters 192 P0AEU5 HISM_ECO57 Histidine transport system permease protein hisM hisM Z3569 ECs3191 238 ABC transporters 193 P0AEY4 MAZG_ECO57 Nucleoside triphosphate pyrophosphohydrolase (NTP-PPase) (ECmazG 3.6.1.8) Z4096 ECs3641 263 Purine metabolism Pyrimidine metabolism 194 P0AF02 MODB_ECO57 Molybdenum transport system permease protein modB modB Z0934 ECs0792 229 ABC transporters 195 P0AF04 MOG_ECO57 Molybdopterin adenylyltransferase (MPT adenylyltransferase) (ECmog 2.7.7.75) Z0009 ECs0009 195 Sulfur relay system 196 P0AF14 MTNN_ECO57 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTA/SAHmtnN Z0170 nucleosidase) ECs0163 (MTAN) (EC 3.2.2.9)232 Cysteine (5'-methylthioadenosine and methionine metabolism nucleosidase) (MTA nucleosidase) (S-adenosylhomocysteine nucleosidase) (AdoHcy nucleosidase) (SAH nucleosidase) (SRH nucleosidase) 197 P0AF17 MURJ_ECO57 Protein MurJ homolog murJ mviN Z1707 ECs1447 511 Peptidoglycan biosynthesis* 198 P0AF19 NAGA_ECO57 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) (GlcNAcnagA 6-P Z0824 deacetylase) ECs0707 382 Amino sugar and nucleotide sugar metabolism 199 P0AF30 NARL_ECO57 Nitrate/nitrite response regulator protein NarL narL Z1996 ECs1726 216 Two-component system* 200 P0AFA0 LPTF_ECO57 Lipopolysaccharide export system permease protein lptF lptF Z5873 ECs5238 366 ABC transporters 201 P0AFB0 NIKC_ECO57 Nickel transport system permease protein nikC nikC Z4870 ECs4345 277 ABC transporters 202 P0AFB9 NTRC_ECO57 Nitrogen regulation protein NR(I) glnG Z5404 ECs4790 469 Two-component system* 203 P0AFC9 NUOB_ECO57 NADH-quinone oxidoreductase subunit B (EC 1.6.99.5) (NADH dehydrogenasenuoB Z3546 ECs3171 I subunit B) (NDH-1 subunit220 OxidativeB) (NUO2) phosphorylation Nitrogen metabolism* 204 P0AFD5 NUOH_ECO57 NADH-quinone oxidoreductase subunit H (EC 1.6.99.5) (NADH dehydrogenasenuoH Z3541 ECs3166 I subunit H) (NDH-1 subunit325 Oxidative H) (NUO8) phosphorylation Nitrogen metabolism* 205 P0AFD8 NUOI_ECO57 NADH-quinone oxidoreductase subunit I (EC 1.6.99.5) (NADH dehydrogenasenuoI Z3540 ECs3165 I subunit I) (NDH-1 subunit180 I)Nitrogen (NUO9) metabolism* 206 P0AFE9 NUOM_ECO57 NADH-quinone oxidoreductase subunit M (EC 1.6.99.5) (NADH nuoMdehydrogenase Z3536 ECs3161 I subunit M) (NDH-1 subunit509 Oxidative M) (NUO13) phosphorylation Nitrogen metabolism* 207 P0AFG5 ODO1_ECO57 2-oxoglutarate dehydrogenase E1 component (EC 1.2.4.2) (Alpha-ketoglutaratesucA Z0880 ECs0751 dehydrogenase) 933 Citrate cycle (TCA cycle) Lysine degradation Tryptophan metabolism 208 P0AFG7 ODO2_ECO57 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutaratesucB Z0881 dehydrogenaseECs0752 complex (EC405 2.3.1.61)Citrate (2-oxoglutaratecycle (TCA cycle) dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) Lysine degradation 209 P0AFG9 ODP1_ECO57 Pyruvate dehydrogenase E1 component (EC 1.2.4.1) aceE Z0124 ECs0118 887 Glycolysis / Gluconeogenesis Citrate cycle (TCA cycle) Valine, leucine and isoleucine biosynthesis Pyruvate metabolism Butanoate metabolism 210 P0AFH7 OPPC_ECO57 Oligopeptide transport system permease protein oppC oppC Z2021 ECs1745 302 ABC transporters 211 P0AFI1 OXC_ECO57 Probable oxalyl-CoA decarboxylase (EC 4.1.1.8) oxc Z3637 ECs3253 564 Glyoxylate and dicarboxylate metabolism 212 P0AFJ3 PHNA_ECO57 Protein phnA phnA Z5710 ECs5090 111 Phosphonate and phosphinate metabolism* 213 P0AFJ6 PHOB_ECO57 Phosphate regulon transcriptional regulatory protein phoB phoB Z0497 ECs0449 229 Two-component system* 214 P0AFK8 POTC_ECO57 Spermidine/putrescine transport system permease protein PotC potC Z1763 ECs1500 264 ABC transporters 215 P0AFL8 PPX_ECO57 Exopolyphosphatase (ExopolyPase) (EC 3.6.1.11) (Metaphosphatase)ppx Z3765 ECs3364 513 Purine metabolism 216 P0AFU5 QSEF_ECO57 Transcriptional regulatory protein QseF (Quorum-sensing regulatorqseF protein yfhA F) Z3830 ECs3420 444 Two-component system* 217 P0AG04 UBIX_ECO57 3-octaprenyl-4-hydroxybenzoate carboxy-lyase (EC 4.1.1.-) (PolyprenylubiX Z3573 p-hydroxybenzoate ECs3195 decarboxylase)189 Ubiquinone and other terpenoid-quinone biosynthesis 218 P0AG09 RPE_ECO57 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) (Pentose-5-phosphaterpe 3-epimerase) Z4739 ECs4228 (PPE) (R5P3E) 225 Pentose phosphate pathway Pentose and glucuronate interconversions 219 P0AG19 PURE_ECO57 N5-carboxyaminoimidazole ribonucleotide mutase (N5-CAIR mutase)purE (ECZ0678 5.4.99.18) ECs0585 (5-(carboxyamino)imidazole169 Purine ribonucleotide metabolism mutase) 220 P0AG22 RELA_ECO57 GTP pyrophosphokinase (EC 2.7.6.5) ((p)ppGpp synthase) (ATP:GTPrelA Z40993'-pyrophosphotransferase) ECs3644 (ppGpp744 synthasePurine I) metabolism 221 P0AG25 SPOT_ECO57 Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2)spoT Z5076 (Penta-phosphate ECs4525 guanosine-3'-pyrophosphohydrolase)702 Purine metabolism ((ppGpp)ase) 222 P0AG32 RHO_ECO57 Transcription termination factor Rho (EC 3.6.4.-) (ATP-dependentrho helicase Z5293 Rho) ECs4716 419 RNA degradation 223 P0AG42 RIBF_ECO57 Riboflavin biosynthesis protein RibF [Includes: Riboflavin kinaseribF (EC Z00292.7.1.26) ECs0028 (Flavokinase); FMN adenylyltransferase313 Riboflavin metabolism(EC 2.7.7.2) (FAD pyrophosphorylase) (FAD synthase)] 224 P0AG46 RL17_ECO57 50S ribosomal protein L17 rplQ Z4664 ECs4159 127 Ribosome 225 P0AG49 RL21_ECO57 50S ribosomal protein L21 rplU Z4549 ECs4065 103 Ribosome 226 P0AG53 RL30_ECO57 50S ribosomal protein L30 rpmD Z4672 ECs4167 59 Ribosome 227 P0AG57 RL6_ECO57 50S ribosomal protein L6 rplF Z4675 ECs4170 177 Ribosome 228 P0AG61 RS14_ECO57 30S ribosomal protein S14 rpsN Z4677 ECs4172 101 Ribosome 229 P0AG65 RS17_ECO57 30S ribosomal protein S17 rpsQ Z4681 ECs4176 84 Ribosome 230 P0AG69 RS1_ECO57 30S ribosomal protein S1 rpsA Z1257 ECs0994 557 Ribosome 231 P0AG88 SECB_ECO57 Protein-export protein SecB secB Z5036 ECs4487 155 Protein export Bacterial secretion system* 232 P0AG91 SECD_ECO57 Protein translocase subunit SecD secD Z0507 ECs0459 615 Protein export Bacterial secretion system* 233 P0AG95 SECF_ECO57 Protein translocase subunit SecF secF Z0508 ECs0460 323 Protein export Bacterial secretion system* 234 P0AG98 SECE_ECO57 Preprotein translocase subunit SecE secE Z5554 ECs4904 127 Protein export Bacterial secretion system* 235 P0AGA1 SECG_ECO57 Protein-export membrane protein SecG (P12) (Preprotein translocasesecG band Z4537 1 subunit) ECs4054 110 Protein export Bacterial secretion system* 236 P0AGA4 SECY_ECO57 Protein translocase subunit SecY secY Z4670 ECs4165 443 Protein export Bacterial secretion system* 237 P0AGB1 SERB_ECO57 Phosphoserine phosphatase (PSP) (PSPase) (EC 3.1.3.3) (O-phosphoserineserB Z5989 phosphohydrolase) ECs5346 322 Glycine, serine and threonine metabolism Methane metabolism* 238 P0AGD9 SRP54_ECO57 Signal recognition particle protein (Fifty-four homolog) ffh Z3904 ECs3473 453 Protein export Bacterial secretion system* 239 P0AGE2 SSB_ECO57 Single-stranded DNA-binding protein (SSB) (Helix-destabilizing ssbprotein) Z5658 ECs5041 178 DNA replication Mismatch repair Homologous recombination 240 P0AGF1 SUCD_ECO57 Succinyl-CoA ligase [ADP-forming] subunit alpha (EC 6.2.1.5) (Succinyl-CoAsucD Z0883 ECs0754 synthetase subunit alpha) 289(SCS-alpha)Citrate cycle (TCA cycle) Propanoate metabolism C5-Branched dibasic acid metabolism* 241 P0AGF8 TDCB_ECO57 L-threonine dehydratase catabolic TdcB (EC 4.3.1.19) (L-serine dehydratase)tdcB Z4469 (ECECs3997 4.3.1.17) (Threonine deaminase)329 Glycine, serine and threonine metabolism Valine, leucine and isoleucine biosynthesis 242 P0AGK0 SYY_ECO57 Tyrosine--tRNA ligase (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS)tyrS Z2650 ECs2346 424 Aminoacyl-tRNA biosynthesis 243 P0AGK3 UBIA_ECO57 4-hydroxybenzoate octaprenyltransferase (EC 2.5.1.-) (4-HB polyprenyltransferase)ubiA Z5639 ECs5023 290 Ubiquinone and other terpenoid-quinone biosynthesis 244 P0C020 RL18_ECO57 50S ribosomal protein L18 rplR Z4674 ECs4169 117 Ribosome 245 P0C0V1 DEGP_ECO57 Periplasmic serine endoprotease DegP (EC 3.4.21.107) (Heat shockdegP protein htrA DegP)ptd Z0173 (Protease ECs0165 Do) 474 Two-component system* 246 P58057 PPNK_ECO57 Probable inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATPppnK NAD Z3908 kinase) ECs3477 (EC 2.7.1.23) 292 Nicotinate and nicotinamide metabolism 247 P58072 G3P3_ECO57 Glyceraldehyde-3-phosphate dehydrogenase C (GAPDH-C) (EC 1.2.1.12)gapC Z2304 ECs2022 333 Glycolysis / Gluconeogenesis 248 P58130 PLSB_ECO57 Glycerol-3-phosphate acyltransferase (GPAT) (EC 2.3.1.15) plsB Z5640 ECs5024 807 Glycerolipid metabolism Glycerophospholipid metabolism 249 P58194 UBID_ECO57 3-octaprenyl-4-hydroxybenzoate carboxy-lyase (EC 4.1.1.-) (PolyprenylubiD Z5364 p-hydroxybenzoate ECs4771 decarboxylase)497 Ubiquinone and other terpenoid-quinone biosynthesis 250 P58209 DAPB_ECO57 Dihydrodipicolinate reductase (DHPR) (EC 1.3.1.26) dapB Z0036 ECs0034 273 Lysine biosynthesis 251 P58220 GHRB_ECO57 Glyoxylate/hydroxypyruvate reductase B (EC 1.1.1.79) (EC 1.1.1.81)tkrA Z4978 ECs4438 324 Pentose phosphate pathway 252 P58237 HIS5_ECO57 Imidazole glycerol phosphate synthase subunit HisH (EC 2.4.2.-) hisH(IGP Z3185synthase ECs2824 glutamine amidotransferase196 subunit)Histidine (IGP metabolism synthase subunit HisH) (ImGP synthase subunit HisH) (IGPS subunit HisH) 253 P58256 ILVC_ECO57 Ketol-acid reductoisomerase (EC 1.1.1.86) (Acetohydroxy-acid isomeroreductase)ilvC Z5285 ECs4708 (Alpha-keto-beta-hydroxylacil491 Valine, reductoisomerase) leucine and isoleucine biosynthesis Pantothenate and CoA biosynthesis 254 P58263 THIG_ECO57 Thiazole synthase (EC 2.8.1.10) thiG Z5565 ECs4914 256 Thiamine metabolism 255 P58357 TORR_ECO57 TorCAD operon transcriptional regulatory protein torR torR Z1412 ECs1150 230 Two-component system* 256 P58364 TORD_ECO57 Chaperone protein TorD torD Z1416 ECs1153 199 Two-component system* 257 P58473 PEPB_ECO57 Peptidase B (EC 3.4.11.23) (Aminopeptidase B) pepB Z3790 ECs3389 427 Glutathione metabolism 258 P58578 GSHB_ECO57 Glutathione synthetase (EC 6.3.2.3) (GSH synthetase) (GSH-S) (GSHase)gshB Z4292 (Glutathione ECs3823 synthase) 315 Glutathione metabolism 259 P58640 PYRF_ECO57 Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) (OMP decarboxylase)pyrF Z2525 (OMPDCase) ECs1854 (OMPdecase) 245 Pyrimidine metabolism 260 P58646 ATPE_ECO57 ATP synthase epsilon chain (ATP synthase F1 sector epsilon subunit)atpC (F-ATPase papG uncC epsilon Z5229 subunit) ECs4673 139 Oxidative phosphorylation 261 P58694 SYN_ECO57 Asparagine--tRNA ligase (EC 6.1.1.22) (Asparaginyl-tRNA synthetase)asnS tss (AsnRS) Z1278 ECs1013 466 Aminoacyl-tRNA biosynthesis 262 P58704 CYNS_ECO57 Cyanate hydratase (Cyanase) (EC 4.2.1.104) (Cyanate hydrolase) cynS(Cyanate cnt Z0436lyase) ECs0393 156 Nitrogen metabolism* 263 P58713 PDXA_ECO57 4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262) (4-(phosphohydroxy)-L-threoninepdxA Z0061 ECs0057 dehydrogenase)329 Vitamin B6 metabolism 264 P60424 RL2_ECO57 50S ribosomal protein L2 rplB Z4688 ECs4182 273 Ribosome 265 P60440 RL3_ECO57 50S ribosomal protein L3 rplC Z4691 ECs4185 209 Ribosome 266 P60474 UPPS_ECO57 Undecaprenyl pyrophosphate synthase (UPP synthase) (EC 2.5.1.31)uppS (Di-trans,poly-cis-decaprenylcistransferase) Z0185 ECs0176 253 Terpenoid (Ditrans,polycis-undecaprenyl-diphosphate backbone biosynthesis synthase) (Undecaprenyl diphosphate synthase) (UDS) 267 P60625 RL24_ECO57 50S ribosomal protein L24 rplX Z4679 ECs4174 104 Ribosome 268 P60665 HIS6_ECO57 Imidazole glycerol phosphate synthase subunit HisF (EC 4.1.3.-) (IGPhisF Z3187synthase ECs2826 cyclase subunit) (IGP synthase258 Histidine subunit HisF) metabolism (ImGP synthase subunit HisF) (IGPS subunit HisF) 269 P60718 LIPA_ECO57 Lipoyl synthase (EC 2.8.1.8) (Lip-syn) (LS) (Lipoate synthase) (LipoiclipA Z0773 acid synthase) ECs0666 (Sulfur insertion protein321 Lipoic LipA) acid metabolism 270 P60721 LIPB_ECO57 Octanoyltransferase (EC 2.3.1.181) (Lipoate-protein ligase B) (Lipoyl/octanoyllipB Z0775 ECs0668 transferase) (Octanoyl-[acyl-carrier-protein]-protein213 Lipoic acid metabolism N-octanoyltransferase) 271 P60725 RL4_ECO57 50S ribosomal protein L4 rplD Z4690 ECs4184 201 Ribosome 272 P60753 MSBA_ECO57 Lipid A export ATP-binding/permease protein MsbA (EC 3.6.3.-) msbA Z1260 ECs0997 582 ABC transporters 273 P60784 PLSY_ECO57 Glycerol-3-phosphate acyltransferase (G3P acyltransferase) (GPAT)plsY (EC ygiH 2.3.1.15) Z4412 (EC ECs3942 2.3.1.n5) (Lysophosphatidic205 Glycerolipid acid synthase) metabolism (LPA synthase) Glycerophospholipid metabolism 274 P60908 SYH_ECO57 Histidine--tRNA ligase (EC 6.1.1.21) (Histidyl-tRNA synthetase) hisS(HisRS) Z3777 ECs3376 424 Aminoacyl-tRNA biosynthesis 275 P60933 UPPP_ECO57 Undecaprenyl-diphosphatase (EC 3.6.1.27) (Bacitracin resistance uppPprotein) bacA (Undecaprenyl upk Z4410 ECs3940 pyrophosphate phosphatase)273 Peptidoglycan biosynthesis* 276 P61177 RL22_ECO57 50S ribosomal protein L22 rplV Z4686 ECs4180 110 Ribosome 277 P61717 RISB_ECO57 6,7-dimethyl-8-ribityllumazine synthase (DMRL synthase) (LumazineribH synthase)ribE Z0516 (EC ECs0468 2.5.1.9) (Riboflavin 156synthaseRiboflavin beta chain) metabolism 278 P61891 MDH_ECO57 Malate dehydrogenase (EC 1.1.1.37) mdh mdhA Z4595 ECs4109 312 Citrate cycle (TCA cycle) Pyruvate metabolism Glyoxylate and dicarboxylate metabolism Methane metabolism* 279 P61951 FLAV_ECO57 Flavodoxin-1 fldA Z0832 ECs0715 176 Nitrogen metabolism* 280 P62397 SECM_ECO57 Secretion monitor secM Z0107 ECs0101 170 Protein export Bacterial secretion system* 281 P62401 RL5_ECO57 50S ribosomal protein L5 rplE Z4678 ECs4173 179 Ribosome 282 P62616 ISPE_ECO57 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (CMK) (EC 2.7.1.148)ispE Z1979 (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol ECs1713 283 Terpenoid backbone kinase) biosynthesis 283 P62618 ISPF_ECO57 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECDP-synthase)ispF Z4054 (MECPS) ECs3600 (EC 4.6.1.12) 159 Terpenoid backbone biosynthesis 284 P62622 ISPG_ECO57 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (EC 1.17.7.1)ispG (1-hydroxy-2-methyl-2-(E)-butenyl gcpE Z3778 ECs3377 372 4-diphosphateTerpenoid backbonesynthase) biosynthesis 285 P62625 ISPH_ECO57 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC 1.17.1.2)ispH lytB Z0034 ECs0032 316 Terpenoid backbone biosynthesis 286 P62709 GPMA_ECO57 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (BPG-dependentgpmA gpm pgm PGAM) pgmA (PGAM) Z0925 ECs0783 (Phosphoglyceromutase)250 Glycolysis / Gluconeogenesis(dPGM) (EC 5.4.2.1) Glycine, serine and threonine metabolism Methane metabolism* 287 P63225 GMHA_ECO57 Phosphoheptose isomerase (EC 5.3.1.28) (Sedoheptulose 7-phosphategmhA isomerase) lpcA Z0280 ECs0249 192 Lipopolysaccharide biosynthesis* 289 P63229 GMHB_ECO57 D,D-heptose 1,7-bisphosphate phosphatase (EC 3.1.3.-) (D-glycero-D-manno-heptosegmhB Z0212 ECs0202 1,7-bisphosphate phosphatase)191 Lipopolysaccharide (HBP phosphatase) biosynthesis* 290 P63356 METN_ECO57 Methionine import ATP-binding protein MetN (EC 3.6.3.-) metN Z0211 ECs0201 343 ABC transporters 291 P63486 ALLA_ECO57 Ureidoglycolate hydrolase (EC 3.5.3.19) allA Z0659 ECs0566 160 Purine metabolism 292 P63610 AROC_ECO57 Chorismate synthase (EC 4.2.3.5) (5-enolpyruvylshikimate-3-phosphatearoC Z3592 phospholyase) ECs3213 361 Phenylalanine, tyrosine and tryptophan biosynthesis 293 P63624 ASNA_ECO57 Aspartate--ammonia ligase (EC 6.3.1.1) (Asparagine synthetase A)asnA Z5245 ECs4686 330 Alanine, aspartate and glutamate metabolism Cyanoamino acid metabolism Nitrogen metabolism* 294 P63633 MURI_ECO57 Glutamate racemase (EC 5.1.1.3) murI Z5528 ECs4898 285 D-Glutamine and D-glutamate metabolism 295 P63737 CARB_ECO57 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) (Carbamoyl-phosphatecarB Z0038 ECs0036 synthetase ammonia chain)1073 Pyrimidine metabolism Alanine, aspartate and glutamate metabolism 296 P63944 DAPA_ECO57 Dihydrodipicolinate synthase (DHDPS) (EC 4.2.1.52) dapA Z3737 ECs3340 292 Lysine biosynthesis 297 P64007 DUT_ECO57 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (ECdut 3.6.1.23) Z5064 (dUTPECs4515 pyrophosphatase) 151 Pyrimidine metabolism 298 P64258 MRAY_ECO57 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13)mraY (UDP-MurNAc-pentapeptide Z0097 ECs0091 phosphotransferase)360 Peptidoglycan biosynthesis* 299 P64295 GUAA_ECO57 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase)guaA Z3771(Glutamine ECs3369 amidotransferase) 525 Purine metabolism 300 P64558 YGFM_ECO57 Uncharacterized protein ygfM ygfM Z4219 ECs3753 259 Selenocompound metabolism 301 P65323 LPXD_ECO57 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase (UDP-3-O-(3-OHC14)-GlcNlpxD Z0191 ECs0181 N-acyltransferase)341 Lipopolysaccharide (EC 2.3.1.191) biosynthesis* 302 P65471 MURC_ECO57 UDP-N-acetylmuramate--L-alanine ligase (EC 6.3.2.8) (UDP-N-acetylmuramoyl-L-alaninemurC Z0101 ECs0095 synthetase) 491 D-Glutamine and D-glutamate metabolism Peptidoglycan biosynthesis* 303 P65625 YIDC_ECO57 Membrane protein insertase YidC (Foldase YidC) (Membrane integraseyidC Z5197 YidC) ECs4640(Membrane protein YidC) 548 Protein export Bacterial secretion system* 304 P65737 PLSX_ECO57 Phosphate acyltransferase (EC 2.3.1.n2) (Acyl-ACP phosphotransacylase)plsX Z1729 (Acyl-[acyl-carrier-protein]--phosphate ECs1468 356 Glycerolipid acyltransferase) metabolism (Phosphate-acyl-ACP acyltransferase) Glycerophospholipid metabolism 305 P65871 QUED_ECO57 6-carboxy-5,6,7,8-tetrahydropterin synthase (CPH4 synthase) (ECqueD 4.1.2.50) ygcM (Queuosine Z4075 ECs3620 biosynthesis protein121 queD)Folate biosynthesis 306 P66072 RL15_ECO57 50S ribosomal protein L15 rplO Z4671 ECs4166 144 Ribosome 307 P66607 RS7_ECO57 30S ribosomal protein S7 rpsG Z4699 ECs4192 156 Ribosome 308 P66794 SELD_ECO57 Selenide, water dikinase (EC 2.7.9.3) (Selenium donor protein) (SelenophosphateselD Z2797 ECs2470 synthase) 347 Selenocompound metabolism 309 P67026 SYGA_ECO57 Glycine--tRNA ligase alpha subunit (EC 6.1.1.14) (Glycyl-tRNA synthetaseglyQ Z4984 alpha ECs4443 subunit) (GlyRS) 303 Aminoacyl-tRNA biosynthesis 310 P67031 SYGB_ECO57 Glycine--tRNA ligase beta subunit (EC 6.1.1.14) (Glycyl-tRNA synthetaseglyS Z4983 beta ECs4442 subunit) (GlyRS) 689 Aminoacyl-tRNA biosynthesis 311 P67037 SYFA_ECO57 Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNApheS Z2743 synthetaseECs2421 alpha subunit) (PheRS)327 Aminoacyl-tRNA biosynthesis 312 P67589 SYW_ECO57 Tryptophan--tRNA ligase (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase)trpS Z4737 (TrpRS) ECs4226 334 Aminoacyl-tRNA biosynthesis 313 P67676 PRIB_ECO57 Primosomal replication protein n priB Z5810 ECs5177 104 Homologous recombination 314 P67911 HLDD_ECO57 ADP-L-glycero-D-manno-heptose-6-epimerase (EC 5.1.3.20) (ADP-L-glycero-beta-D-manno-heptose-6-epimerase)hldD rfaD Z5046 ECs4497 310 Lipopolysaccharide (ADP-glyceromanno-heptose biosynthesis* 6-epimerase) (ADP-hep 6-epimerase) (AGME) 315 P68188 MALK_ECO57 Maltose/maltodextrin import ATP-binding protein MalK (EC 3.6.3.19)malK Z5633 ECs5018 371 ABC transporters 316 P68681 RS21_ECO57 30S ribosomal protein S21 rpsU Z4418 ECs3948 71 Ribosome 317 P68768 AMPA_ECO57 Cytosol aminopeptidase (EC 3.4.11.1) (Aminopeptidase A/I) (LeucinepepA aminopeptidase) carP xerB Z5872 (LAP) ECs5237 (EC 3.4.11.10)503 (LeucylGlutathione aminopeptidase) metabolism 318 P69055 DHSC_ECO57 Succinate dehydrogenase cytochrome b556 subunit (Cytochrome b-556)sdhC cybA Z0875 ECs0746 129 Citrate cycle (TCA cycle) Oxidative phosphorylation Butanoate metabolism Toluene degradation* 319 P69424 TATC_ECO57 Sec-independent protein translocase protein TatC tatC mttB Z5360 ECs4768 258 Bacterial secretion system* 320 P69442 KAD_ECO57 Adenylate kinase (AK) (EC 2.7.4.3) (ATP-AMP transphosphorylase)adk dnaW plsA Z0591 ECs0527 214 Purine metabolism 321 P69772 PAD1_ECO57 Probable aromatic acid decarboxylase (EC 4.1.1.-) pad1 Z4047 ECs3593 197 Ubiquinone and other terpenoid-quinone biosynthesis 322 P69788 PTGCB_ECO57 PTS system glucose-specific EIICB component (EIICB-Glc) (EII-Glc)ptsG Z1740[Includes: ECs1479 Glucose permease IIC component477 Glycolysis (PTS / system Gluconeogenesis glucose-specific EIIC component); Glucose-specific phosphotransferase enzyme IIB component (EC 2.7.1.69) (PTS system glucose-specific EIIB component)] Amino sugar and nucleotide sugar metabolism Phosphotransferase system* 323 P69793 PTQA_ECO57 N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIA componentchbA celC (ECZ2766 2.7.1.-) ECs2442 (EIIA-Chb) (EIII-Chb)116 Phosphotransferase (PTS system N,N'-diacetylchitobiose-specific system* EIIA component) 324 P69799 PTNAB_ECO57 PTS system mannose-specific EIIAB component (EIIAB-Man) [Includes:manX Z2860 Mannose-specific ECs2527 phosphotransferase323 Fructose enzyme and IIA mannose component metabolism (EC 2.7.1.-) (EIII-Man) (PTS system mannose-specific EIIA component); Mannose-specific phosphotransferase enzyme IIB component (EC 2.7.1.69) (PTS system mannose-specific EIIB component)] Amino sugar and nucleotide sugar metabolism Phosphotransferase system* 325 P69812 PTFAH_ECO57 Multiphosphoryl transfer protein (MTP) (Phosphotransferase FPr fruBprotein) Z3427 (Pseudo-HPr) ECs3061 [Includes: Phosphocarrier376 Fructose protein and HPr mannose (Protein metabolism H); Fructose-specific phosphotransferase enzyme IIA component (EC 2.7.1.-) (PTS system fructose-specific EIIA component)] Phosphotransferase system* 326 P69827 PTMCB_ECO57 PTS system mannitol-specific cryptic EIICB component (EIICB-Mtl)cmtA (EII-Mtl) Z4277 ECs3808 [Includes: Mannitol permease462 FructoseIIC component and mannose (PTS system metabolism mannitol-specific EIIC component); Mannitol-specific phosphotransferase enzyme IIB component (EC 2.7.1.69) (PTS system mannitol-specific EIIB component)] Phosphotransferase system* 327 P69830 PTQB_ECO57 N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIB componentchbB celA (ECZ2768 2.7.1.69) ECs2444 (PTS system N,N'-diacetylchitobiose-specific106 Phosphotransferase system* EIIB component) 328 P69876 POTA_ECO57 Spermidine/putrescine import ATP-binding protein PotA (EC 3.6.3.31)potA Z1831 ECs1571 378 ABC transporters 329 P69915 CSRA_ECO57 Carbon storage regulator csrA zfiA Z3998 ECs3553 61 Two-component system* 330 P69925 RIR2_ECO57 Ribonucleoside-diphosphate reductase 1 subunit beta (EC 1.17.4.1)nrdB (Protein ftsB Z3491B2) (Protein ECs3118 R2) (Ribonucleotide376 Purinereductase metabolism 1) Pyrimidine metabolism 331 Q7A8J7 Q7A8J7_ECO57 Methyl-accepting chemotaxis protein I ECs5315 554 Two-component system* Bacterial chemotaxis* 332 Q7A909 Q7A909_ECO57 Putative aldolase ECs5069 286 Glycolysis / Gluconeogenesis Pentose phosphate pathway Fructose and mannose metabolism Methane metabolism* 333 Q7A978 KATG1_ECO57 Catalase-peroxidase 1 (CP 1) (EC 1.11.1.21) (Peroxidase/catalase katG11) Z5497 ECs4871 726 Phenylalanine metabolism Tryptophan metabolism Methane metabolism* 334 Q7A9F6 Q7A9F6_ECO57 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) ECs4721 355 Streptomycin biosynthesis* Polyketide sugar unit biosynthesis* 335 Q7A9K8 Q7A9K8_ECO57 Acetolactate synthase (EC 2.2.1.6) ECs4612 562 Valine, leucine and isoleucine biosynthesis Butanoate metabolism Pantothenate and CoA biosynthesis C5-Branched dibasic acid metabolism* 336 Q7A9V4 Q7A9V4_ECO57 Mannitol-specific PTS system enzyme IIABC components ECs4475 637 Fructose and mannose metabolism Phosphotransferase system* 337 Q7A9Z2 Q7A9Z2_ECO57 Dipeptide transport protein ECs4424 535 ABC transporters Bacterial chemotaxis* 338 Q7AA01 Q7AA01_ECO57 Ketodeoxygluconokinase ECs4406 382 Pentose phosphate pathway Pentose and glucuronate interconversions 339 Q7AA24 Q7AA24_ECO57 Glutathione oxidoreductase ECs4372 450 Glutathione metabolism 340 Q7AAG8 Q7AAG8_ECO57 Glutamate synthase large subunit ECs4091 1517 Alanine, aspartate and glutamate metabolism Nitrogen metabolism* 341 Q7AAK7 Q7AAK7_ECO57 N-acetylgalactosamine-specific PTS system enzyme IIB componentECs4011 169 Galactose metabolism Phosphotransferase system* 342 Q7AAL3 Q7AAL3_ECO57 Putative uncharacterized protein ECs4002 ECs4002 408 Glycine, serine and threonine metabolism Glycerolipid metabolism Glyoxylate and dicarboxylate metabolism 343 Q7AAL9 Q7AAL9_ECO57 L-serine deaminase ECs3992 454 Glycine, serine and threonine metabolism Cysteine and methionine metabolism 344 Q7AAQ7 HLDE_ECO57 Bifunctional protein HldE [Includes: D-beta-D-heptose 7-phosphatehldE kinase rfaE (ECZ4405 2.7.1.-) ECs3935 (D-beta-D-heptose477 7-phosphotransferase);Lipopolysaccharide biosynthesis*D-beta-D-heptose 1-phosphate adenosyltransferase (EC 2.7.7.-)] 345 Q7AAT1 Q7AAT1_ECO57 Cystathionine beta-lyase ECs3892 395 Cysteine and methionine metabolism Selenocompound metabolism Sulfur metabolism 346 Q7AAX8 Q7AAX8_ECO57 Transketolase 1 isozyme ECs3810 663 Pentose phosphate pathway 347 Q7AAZ5 Q7AAZ5_ECO57 2-octaprenyl-6-methoxyphenol 4-monoxygenase ECs3778 392 Ubiquinone and other terpenoid-quinone biosynthesis 348 Q7AB45 Q7AB45_ECO57 2-deoxy-D-gluconate 3-dehydrogenase ECs3699 253 Pentose and glucuronate interconversions 349 Q7ABN3 Q7ABN3_ECO57 Phosphoribosylglycinamide formyltransferase 1 ECs3362 212 Purine metabolism One carbon pool by folate 350 Q7ABQ6 Q7ABQ6_ECO57 Transketolase 2 isozyme ECs3327 667 Pentose phosphate pathway 351 Q7ABQ7 Q7ABQ7_ECO57 Putative multimodular enzyme ECs3325 759 Pyruvate metabolism 352 Q7ABT1 Q7ABT1_ECO57 Sulfate transport system permease W protein ECs3294 149 ABC transporters 353 Q7ABV7 Q7ABV7_ECO57 Multidrug resistance protein Y ECs3246 512 Two-component system* 354 Q7ABY7 Q7ABY7_ECO57 3-oxoacyl-[acyl-carrier-protein] synthase I ECs3207 406 Fatty acid biosynthesis 355 Q7ABZ7 Q7ABZ7_ECO57 ATP-binding component of histidine transport ECs3190 257 ABC transporters 356 Q7AC15 Q7AC15_ECO57 Isochorismate hydroxymutase 2 ECs3153 356 Ubiquinone and other terpenoid-quinone biosynthesis Biosynthesis of siderophore group nonribosomal peptides* 357 Q7AC18 Q7AC18_ECO57 Dihydroxynaphtoic acid synthetase ECs3150 285 Ubiquinone and other terpenoid-quinone biosynthesis 359 Q7AC19 Q7AC19_ECO57 O-succinylbenzoate-CoA ligase ECs3148 451 Ubiquinone and other terpenoid-quinone biosynthesis 360 Q7AC69 Q7AC69_ECO57 Putative ATP-binding component of a transport system ECs3072 529 ABC transporters 361 Q7AC70 Q7AC70_ECO57 Putative transport system permease protein ECs3071 341 ABC transporters 362 Q7ACR3 Q7ACR3_ECO57 Exonuclease I ECs2813 475 Mismatch repair 363 Q7AD45 Q7AD45_ECO57 L-arabinose-binding periplasmic protein ECs2609 329 ABC transporters 364 Q7AD51 Q7AD51_ECO57 Methyl-accepting chemotaxis protein II ECs2596 553 Two-component system* 365 Q7AD69 Q7AD69_ECO57 Pyruvate kinase (EC 2.7.1.40) ECs2564 480 Glycolysis / Gluconeogenesis Purine metabolism Pyruvate metabolism 366 Q7AD93 Q7AD93_ECO57 L-serine deaminase ECs2523 454 Glycine, serine and threonine metabolism Cysteine and methionine metabolism 367 Q7AD95 Q7AD95_ECO57 p-aminobenzoate synthetase component I ECs2521 453 Folate biosynthesis 368 Q7ADE7 ASTB_ECO57 N-succinylarginine dihydrolase (EC 3.5.3.23) astB Z2777 ECs2451 447 Arginine and proline metabolism 369 Q7ADI4 SUFS_ECO57 Cysteine desulfurase (EC 2.8.1.7) (Selenocysteine beta-lyase) (SCL)sufS (Selenocysteine Z2708 ECs2387 lyase) (EC 4.4.1.16)406 (SelenocysteineSelenocompound reductase) metabolism Thiamine metabolism 370 Q7ADK8 Q7ADK8_ECO57 Endonuclease III ECs2342 211 Base excision repair 371 Q7ADM2 Q7ADM2_ECO57 Sensor histidine protein kinase RstA regulator ECs2315 433 Two-component system* 372 Q7ADN3 Q7ADN3_ECO57 Putative oxidoreductase major subunit ECs2294 808 Selenocompound metabolism 373 Q7AE27 Q7AE27_ECO57 Alcohol dehydrogenase ECs2082 346 Glycolysis / Gluconeogenesis Fatty acid metabolism Tyrosine metabolism Chloroalkane and chloroalkene degradation* Naphthalene degradation* Nitrotoluene degradation* 374 Q7AEL5 Q7AEL5_ECO57 Anthranilate synthase component II ECs1835 531 Phenylalanine, tyrosine and tryptophan biosynthesis 375 Q7AEU1 Q7AEU1_ECO57 Formyltetrahydrofolate deformylase ECs1734 280 Glyoxylate and dicarboxylate metabolism One carbon pool by folate 376 Q7AF75 Q7AF75_ECO57 Transcription-repair coupling factor ECs1492 1148 Nucleotide excision repair 377 Q7AF85 Q7AF85_ECO57 4-amino-4-deoxychorismate lyase ECs1474 269 Folate biosynthesis 378 Q7AG48 Q7AG48_ECO57 Aminopeptidase N ECs1015 870 Glutathione metabolism 379 Q7AG83 Q7AG83_ECO57 Arginine 3rd transport system periplasmic binding protein ECs0943 243 ABC transporters 380 Q7AGB8 Q7AGB8_ECO57 ATP-binding component of glutamine high-affinity transport systemECs0887 240 ABC transporters 381 Q7AGD8 Q7AGD8_ECO57 7,8-diaminopelargonic acid synthetase ECs0852 429 Biotin metabolism 382 Q7AGK5 Q7AGK5_ECO57 Citrate synthase (EC 2.3.3.1) ECs0745 427 Citrate cycle (TCA cycle) Glyoxylate and dicarboxylate metabolism 383 Q7AGM2 Q7AGM2_ECO57 Phosphoglucomutase ECs0719 546 Glycolysis / Gluconeogenesis Galactose metabolism Purine metabolism Starch and sucrose metabolism Amino sugar and nucleotide sugar metabolism Streptomycin biosynthesis* 384 Q7AGM8 Q7AGM8_ECO57 PTS system, N-acetylglucosamine-specific enzyme IIABC ECs0709 648 Amino sugar and nucleotide sugar metabolism 385 Q7AGN1 Q7AGN1_ECO57 Oxygenase ECs0700 391 Ubiquinone and other terpenoid-quinone biosynthesis 386 Q7AGQ0 Q7AGQ0_ECO57 Citrate lyase beta chain ECs0655 307 Citrate cycle (TCA cycle) Two-component system* 387 Q7AGQ1 Q7AGQ1_ECO57 Citrate lyase alpha chain ECs0654 510 Citrate cycle (TCA cycle) Two-component system* 388 Q7AGR4 Q7AGR4_ECO57 Ferric enterobactin (Enterochelin) binding protein periplasmic componentECs0631 318 ABC transporters 389 Q7AGY5 Q7AGY5_ECO57 Primosomal replication protein N'' ECs0520 175 Homologous recombination 390 Q7AH33 Q7AH33_ECO57 Delta-aminolevulinic acid dehydratase (EC 4.2.1.24) ECs0423 335 Porphyrin and chlorophyll metabolism 391 Q7AH43 FBPC_ECO57 Fe(3+) ions import ATP-binding protein FbpC (EC 3.6.3.30) fbpC afuC Z0458 ECs0413 348 ABC transporters 392 Q7AH91 BETB_ECO57 Betaine aldehyde dehydrogenase (BADH) (EC 1.2.1.8) betB Z0399 ECs0358 490 Glycine, serine and threonine metabolism 393 Q7AHR4 Q7AHR4_ECO57 Acetolactate synthase (EC 2.2.1.6) ECs0081 588 Valine, leucine and isoleucine biosynthesis Butanoate metabolism Pantothenate and CoA biosynthesis C5-Branched dibasic acid metabolism* 394 Q7DB96 Q7DB96_ECO57 Lipid A-core:surface polymer ligase (Putative LPS biosynthesis enzyme)waaL ECs4500 Z5049 402 Lipopolysaccharide biosynthesis* 395 Q7DBF8 Q7DBF8_ECO57 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)gnd ECs2830 Z3191 468 Pentose phosphate pathway Glutathione metabolism 396 Q7DBF9 UDG_ECO57 UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH)ugd Z3190 (UDPGDH) ECs2829 (EC 1.1.1.22) 388 Pentose and glucuronate interconversions Ascorbate and aldarate metabolism Starch and sucrose metabolism Amino sugar and nucleotide sugar metabolism 397 Q7DKV4 Q7DKV4_ECO57 Type 4 prepilin-like proteins leader peptide-processing enzyme (ECetpN 2.1.1.-) ECO57PM12 238 Bacterial secretion system* 398 Q8X2E4 Q8X2E4_ECO57 Uracil-DNA glycosylase (EC 3.2.2.27) ECs3446 218 Base excision repair 399 Q8X2R8 Q8X2R8_ECO57 Replication protein P ECs1190 483 DNA replication 400 Q8X3I8 Q8X3I8_ECO57 Threonine deaminase ECs4706 514 Glycine, serine and threonine metabolism Valine, leucine and isoleucine biosynthesis 401 Q8X3W8 SYA_ECO57 Alanine--tRNA ligase (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS)alaS Z3999 ECs3554 876 Aminoacyl-tRNA biosynthesis 402 Q8X4I9 ALR2_ECO57 Alanine racemase, catabolic (EC 5.1.1.1) dadX dadB Z1953 ECs1685 356 D-Alanine metabolism* 403 Q8X4K8 Q8X4K8_ECO57 Putative ATP-binding component of dipeptide transport system dppF ECs4420 Z4957 334 ABC transporters 404 Q8X4L6 NIKE_ECO57 Nickel import ATP-binding protein NikE (EC 3.6.3.24) nikE Z4872 ECs4347 268 ABC transporters 405 Q8X4M3 Q8X4M3_ECO57 Putative ATP-binding component of a transport system yehX ECs3016 Z3378 308 ABC transporters 406 Q8X4N9 Q8X4N9_ECO57 Permease of putrescine transport protein (Putrescine transport protein;potI ECs0937permease) Z1084 281 ABC transporters 407 Q8X4Q2 Q8X4Q2_ECO57 Putative oxidoreductase major subunit (Putative oxidoreductase, majorECs2293 subunit) Z2575 808 Selenocompound metabolism 408 Q8X4R2 GATY_ECO57 D-tagatose-1,6-bisphosphate aldolase subunit GatY (TBPA) (TagBPgatY aldolase) Z3259 (ECECs2899 4.1.2.40) (D-tagatose-bisphosphate284 Galactose aldolase metabolism class II) (Tagatose-bisphosphate aldolase) 409 Q8X4R5 Q8X4R5_ECO57 Phosphomannomutase cpsG ECs2853 Z3212 456 Fructose and mannose metabolism Amino sugar and nucleotide sugar metabolism 410 Q8X4S6 ARGD_ECO57 Acetylornithine/succinyldiaminopimelate aminotransferase (ACOAT)argD (DapATase) dapC Z4720 (Succinyldiaminopimelate ECs4210 406 transferase)Lysine biosynthesis (EC 2.6.1.11) (EC 2.6.1.17) Arginine and proline metabolism 411 Q8X4T3 Q8X4T3_ECO57 Putative ATP-binding component of a transport system yhdZ ECs4144 Z4632 252 ABC transporters 412 Q8X4V5 GSA_ECO57 Glutamate-1-semialdehyde 2,1-aminomutase (GSA) (EC 5.4.3.8) hemL(Glutamate-1-semialdehyde gsa popC Z0165 ECs0158 aminotransferase)426 Porphyrin (GSA-AT) and chlorophyll metabolism 413 Q8X4V7 MODC_ECO57 Molybdenum import ATP-binding protein ModC (EC 3.6.3.29) modC Z0935 ECs0793 352 ABC transporters 414 Q8X523 Q8X523_ECO57 DNA polymerase III delta subunit (DNA polymerase III, delta subunit)holA ECs0678 Z0787 343 Purine metabolism Pyrimidine metabolism DNA replication Mismatch repair Homologous recombination 415 Q8X558 Q8X558_ECO57 Homolog of Salmonella ATP-binding protein of oligopeptide ABCoppF transport ECs1747 system Z2023 (Oligopeptide ABC transport334 ABC system transporters ATP-binding protein OppF) 416 Q8X559 Q8X559_ECO57 Homolog of Salmonella ATP-binding protein of oligopeptide ABCoppD transport ECs1746 system Z2022 (Oligopeptide ABC transport337 ABC system transporters ATP-binding protein OppD) 417 Q8X568 Q8X568_ECO57 Putative S-transferase yfcG ECs3186 Z3564 215 Glutathione metabolism 418 Q8X584 Q8X584_ECO57 Putative ABC transporter permease protein (Putative iron compoundECs1698 ABC transporter, Z1965 permease protein) 326 ABC transporters 419 Q8X598 ASTC_ECO57 Succinylornithine transaminase (SOAT) (EC 2.6.1.81) (SuccinylornithineastC argM aminotransferase) Z2780 ECs2454 406 Arginine and proline metabolism 420 Q8X5C8 Q8X5C8_ECO57 Anthranilate synthase component I ECs1836 520 Phenylalanine, tyrosine and tryptophan biosynthesis 421 Q8X5D9 MGLA_ECO57 Galactose/methyl galactoside import ATP-binding protein MglA (ECmglA 3.6.3.17) Z3404 ECs3041 506 ABC transporters 422 Q8X5I2 Q8X5I2_ECO57 Taurine dioxygenase (Taurine dioxygenase, 2-oxoglutarate-dependent)tauD ECs0422 Z0467 283 Taurine and hypotaurine metabolism 423 Q8X5I6 TAUB_ECO57 Taurine import ATP-binding protein TauB (EC 3.6.3.36) tauB Z0465 ECs0420 255 ABC transporters 424 Q8X5J1 Q8X5J1_ECO57 Periplasmic ferric iron-binding protein (Putative periplasmic-iron-bindingafuA ECs0415 protein) Z0460 343 ABC transporters 425 Q8X5J2 Q8X5J2_ECO57 Putative ferric transport system permease (Putative permease componentafuB ECs0414 of transport Z0459 system for ferric iron)692 ABC transporters 426 Q8X5J4 FRMA_ECO57 S-(hydroxymethyl)glutathione dehydrogenase (EC 1.1.1.284) (AlcoholfrmA dehydrogenaseZ0456 ECs0411 class-3) (EC 1.1.1.1)369 (AlcoholGlycolysis dehydrogenase / Gluconeogenesis class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) Fatty acid metabolism Tyrosine metabolism Chloroalkane and chloroalkene degradation* Naphthalene degradation* Nitrotoluene degradation* Methane metabolism* 427 Q8X5K2 Q8X5K2_ECO57 3-methyl-adenine DNA glycosylase I (3-methyladenine DNA glycosylasetag ECs4434 I) Z4974 187 Base excision repair 428 Q8X5M2 DCTA_ECO57 Aerobic C4-dicarboxylate transport protein dctA Z4942 ECs4408 428 Two-component system* 429 Q8X5Q4 RBSA2_ECO57 Ribose import ATP-binding protein RbsA 2 (EC 3.6.3.17) rbsA2 Z5691 ECs5073 506 ABC transporters 430 Q8X5T4 Q8X5T4_ECO57 Formate-dependent nitrite reductase NrfB (Formate-dependent nitritenrfB reductase; ECs5053 aZ5670 penta-haeme cytochrome190 c)Nitrogen metabolism* 431 Q8X5T5 ACSA_ECO57 Acetyl-coenzyme A synthetase (EC 6.2.1.1) (Acetate--CoA ligase)acs (Acyl-activating Z5668 ECs5051 enzyme) 652 Glycolysis / Gluconeogenesis Pyruvate metabolism Propanoate metabolism Methane metabolism* 432 Q8X5U1 NIKD_ECO57 Nickel import ATP-binding protein NikD (EC 3.6.3.24) nikD Z4871 ECs4346 254 ABC transporters 433 Q8X5U5 Q8X5U5_ECO57 Putative 3-oxoacyl-(Acyl-carrier-protein) synthase II (Putative beta-ketoacyl-ACPECs4341 Z4866 synthase) 409 Fatty acid biosynthesis 434 Q8X5U6 Q8X5U6_ECO57 Putative 3-oxoacyl-(Acyl-carrier-protein) reductase (Putative beta-ketoacyl-ACPECs4340 Z4865 reductase) 243 Fatty acid biosynthesis Biosynthesis of unsaturated fatty acids 435 Q8X5U9 UVRA_ECO57 UvrABC system protein A (UvrA protein) (Excinuclease ABC subunituvrA A) Z5657 ECs5040 940 Nucleotide excision repair 436 Q8X5V1 Q8X5V1_ECO57 Tyrosine aminotransferase (Tyrosine aminotransferase, tyrosine repressible)tyrB ECs5036 Z5652 397 Cysteine and methionine metabolism Tyrosine metabolism Phenylalanine metabolism Phenylalanine, tyrosine and tryptophan biosynthesis Novobiocin biosynthesis* 437 Q8X5V2 ALR1_ECO57 Alanine racemase, biosynthetic (EC 5.1.1.1) alr Z5651 ECs5035 359 D-Alanine metabolism* 438 Q8X5V3 DNAB_ECO57 Replicative DNA helicase (EC 3.6.4.12) dnaB Z5650 ECs5034 471 DNA replication 439 Q8X5V9 Q8X5V9_ECO57 Glutathione peroxidase btuE ECs2417 Z2739 183 Glutathione metabolism Arachidonic acid metabolism 440 Q8X5W4 AROH_ECO57 Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive (ECaroH 2.5.1.54) Z2733 (3-deoxy-D-arabino-heptulosonate ECs2411 348 Phenylalanine, 7-phosphate synthase) tyrosine and(DAHP tryptophan synthase) biosynthesis (Phospho-2-keto-3-deoxyheptonate aldolase) 441 Q8X610 META_ECO57 Homoserine O-succinyltransferase (EC 2.3.1.46) (Homoserine O-transsuccinylase)metA Z5599 ECs4931 (HTS) 309 Cysteine and methionine metabolism Sulfur metabolism 442 Q8X611 PUR9_ECO57 Bifunctional purine biosynthesis protein PurH [Includes: PhosphoribosylaminoimidazolecarboxamidepurH Z5583 ECs4929 formyltransferase529 Purine metabolism (EC 2.1.2.3) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (ATIC) (IMP synthase) (Inosinicase)] One carbon pool by folate 443 Q8X612 PUR2_ECO57 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (GlycinamidepurD Z5582 ribonucleotide ECs4928 synthetase) (Phosphoribosylglycinamide429 Purine metabolism synthetase) 444 Q8X622 Q8X622_ECO57 Riboflavin synthase alpha chain (Riboflavin synthase, alpha chain)ribE ECs2371 Z2688 213 Riboflavin metabolism 445 Q8X641 Q8X641_ECO57 Galactose-binding transport protein (Galactose-binding transport protein;mglB ECs3042 receptor Z3405 for galactose taxis) 332 ABC transporters Bacterial chemotaxis* 446 Q8X647 PDXH_ECO57 Pyridoxine/pyridoxamine 5'-phosphate oxidase (EC 1.4.3.5) (PNP/PMPpdxH Z2652oxidase) ECs2347 (PNPOx) (Pyridoxal 5'-phosphate218 Vitamin synthase) B6 metabolism 447 Q8X648 CDD_ECO57 Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase) (CDA)cdd Z3398 ECs3035 294 Pyrimidine metabolism 448 Q8X649 PDXY_ECO57 Pyridoxamine kinase (PM kinase) (EC 2.7.1.35) pdxY Z2648 ECs2345 287 Vitamin B6 metabolism 449 Q8X663 Q8X663_ECO57 PTS system, maltose and glucose-specific II ABC malX ECs2329 Z2626 530 Glycolysis / Gluconeogenesis Starch and sucrose metabolism 450 Q8X677 Q8X677_ECO57 Mannose-6-phosphate isomerase (EC 5.3.1.8) manA ECs2319 Z2616 391 Fructose and mannose metabolism Amino sugar and nucleotide sugar metabolism 451 Q8X6A8 Q8X6A8_ECO57 Carbamate kinase yahI ECs0372 Z0412 316 Purine metabolism Arginine and proline metabolism 452 Q8X6C4 XDHC_ECO57 Xanthine dehydrogenase iron-sulfur-binding subunit xdhC Z4207 ECs3741 159 Purine metabolism 453 Q8X6I7 Q8X6I7_ECO57 Putative acyltransferase yqeF ECs3701 Z4164 394 Fatty acid metabolism Valine, leucine and isoleucine degradation Lysine degradation Tryptophan metabolism Pyruvate metabolism Glyoxylate and dicarboxylate metabolism Propanoate metabolism Terpenoid backbone biosynthesis Benzoate degradation* Two-component system* 454 Q8X6I9 YAGT_ECO57 Putative xanthine dehydrogenase yagT iron-sulfur-binding subunityagT Z0352 ECs0316 229 Purine metabolism 455 Q8X6J0 YAGS_ECO57 Putative xanthine dehydrogenase YagS FAD-binding subunit (EC yagS1.17.1.4) Z0351 ECs0315 318 Purine metabolism 456 Q8X6M7 Q8X6M7_ECO57 DNA helicase RecC (DNA helicase, ATP-dependent dsDNA/ssDNArecC exonuclease ECs3679 Z4139 V subunit, ssDNA endonuclease)1122 Homologous recombination 457 Q8X6N9 Q8X6N9_ECO57 Arginine 3rd transport system periplasmic binding protein artI ECs0946 Z1093 243 ABC transporters 458 Q8X6Q3 Q8X6Q3_ECO57 Putative transport protein ECs0940 Z1087 447 Ascorbate and aldarate metabolism Phosphotransferase system* 459 Q8X6Q9 Q8X6Q9_ECO57 Permease of putrescine transport protein (Putrescine transport protein;potH permease) ECs0936 Z1083 317 ABC transporters 460 Q8X6R1 Q8X6R1_ECO57 ATP-binding component of putrescine transport system potG ECs0935 Z1082 377 ABC transporters 461 Q8X6R2 Q8X6R2_ECO57 Cell division membrane protein ftsY ECs4313 Z4838 498 Protein export Bacterial secretion system* 462 Q8X6R3 FUCK_ECO57 L-fuculokinase (EC 2.7.1.51) (L-fuculose kinase) fucK Z4120 ECs3663 482 Fructose and mannose metabolism 463 Q8X6R5 FUCI_ECO57 L-fucose isomerase (EC 5.3.1.25) (6-deoxy-L-galactose isomerase)fucI (FucIase) Z4119 ECs3662 591 Fructose and mannose metabolism 464 Q8X6R6 Q8X6R6_ECO57 Cell division membrane protein (Cell division membrane protein FtsX)ftsX ECs4311 Z4836 352 ABC transporters 465 Q8X6S0 Q8X6S0_ECO57 L-serine dehydratase (L-serine dehydratase (Deaminase), L-SD2) sdaB ECs3657 Z4114 455 Glycine, serine and threonine metabolism Cysteine and methionine metabolism 466 Q8X6U5 UGPC_ECO57 sn-glycerol-3-phosphate import ATP-binding protein UgpC (EC 3.6.3.20)ugpC Z4818 ECs4296 356 ABC transporters 467 Q8X6V6 GSID_ECO57 Glutathione transport system permease protein gsiD gsiD Z1056 ECs0911 303 ABC transporters 468 Q8X6V9 GSIB_ECO57 Glutathione-binding protein gsiB gsiB Z1054 ECs0909 512 ABC transporters 469 Q8X6W1 GSIA_ECO57 Glutathione import ATP-binding protein GsiA (EC 3.6.3.-) gsiA Z1053 ECs0908 623 ABC transporters 470 Q8X6X5 DCUP_ECO57 Uroporphyrinogen decarboxylase (UPD) (URO-D) (EC 4.1.1.37) hemE Z5572 ECs4920 354 Porphyrin and chlorophyll metabolism 471 Q8X6X6 GLGB_ECO57 1,4-alpha-glucan branching enzyme GlgB (EC 2.4.1.18) (1,4-alpha-D-glucan:1,4-alpha-D-glucanglgB Z4796 ECs4277 6-glucosyl-transferase)728 Starch and (Alpha-(1->4)-glucansucrose metabolism branching enzyme) (Glycogen branching enzyme) (BE) 472 Q8X6X9 THIC_ECO57 Phosphomethylpyrimidine synthase (EC 4.1.99.17) (HydroxymethylpyrimidinethiC Z5569 ECs4917 phosphate synthase) (HMP-P631 synthase)Thiamine (HMP-phosphatemetabolism synthase) (HMPP synthase) (Thiamine biosynthesis protein ThiC) 473 Q8X6Z1 Q8X6Z1_ECO57 Thiamin biosynthesis protein ThiF (Thiamin biosynthesis, thiazolethiF moiety) ECs4915 Z5567 245 Thiamine metabolism Sulfur relay system 474 Q8X709 Q8X709_ECO57 Bifunctional protein BirA biotin-[acetylCoA carboxylase] holoenzymebirA ECs4900synthetase Z5544 / biotin operon repressor321 (Biotin-[acetylCoABiotin metabolism carboxylase] holoenzyme synthetase and biotin operon repressor) 475 Q8X710 Q8X710_ECO57 4-alpha-glucanotransferase (4-alpha-glucanotransferase (Amylomaltase))malQ ECs4258 Z4771 694 Starch and sucrose metabolism 476 Q8X711 MURB_ECO57 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158)murB (UDP-N-acetylmuramate Z5543 ECs4899 dehydrogenase)342 Amino sugar and nucleotide sugar metabolism Peptidoglycan biosynthesis* 477 Q8X722 Q8X722_ECO57 Isocitrate dehydrogenase [NADP] (EC 1.1.1.42) icdA ECs1608 Z1865 416 Citrate cycle (TCA cycle) Glutathione metabolism 478 Q8X726 Q8X726_ECO57 Putative amino acid amidohydrolase (Putative hippuricase) ECs4892 Z5522 388 Phenylalanine metabolism 479 Q8X730 ARLY_ECO57 Argininosuccinate lyase (ASAL) (EC 4.3.2.1) (Arginosuccinase) argH Z5518 ECs4889 457 Alanine, aspartate and glutamate metabolism Arginine and proline metabolism 480 Q8X732 ARGC_ECO57 N-acetyl-gamma-glutamyl-phosphate reductase (AGPR) (EC 1.2.1.38)argC Z5516(N-acetyl-glutamate ECs4887 semialdehyde334 dehydrogenase)Arginine and (NAGSA proline metabolism dehydrogenase) 481 Q8X735 MNMA_ECO57 tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.-) mnmA trmU Z1862 ECs1605 368 Sulfur relay system 482 Q8X737 Q8X737_ECO57 Adenylosuccinate lyase purB ECs1603 Z1860 456 Purine metabolism Alanine, aspartate and glutamate metabolism 483 Q8X743 CAPP_ECO57 Phosphoenolpyruvate carboxylase (PEPC) (PEPCase) (EC 4.1.1.31)ppc Z5514 ECs4885 883 Pyruvate metabolism Methane metabolism* 484 Q8X768 Q8X768_ECO57 Cystathionine gamma-synthase metB ECs4868 Z5494 386 Cysteine and methionine metabolism Selenocompound metabolism Sulfur metabolism 485 Q8X769 FUMC_ECO57 Fumarate hydratase class II (Fumarase C) (EC 4.2.1.2) fumC Z2614 ECs2317 467 Citrate cycle (TCA cycle) 486 Q8X770 Q8X770_ECO57 Response transcriptional regulatory protein (RstB sensor) (ResponserstA transcriptional ECs2314 Z2609 regulatory protein RstB242 sensor)Two-component system* 487 Q8X779 Q8X779_ECO57 Primosomal protein N' (Primosomal protein N'(= factor Y)(PutativepriA helicase)) ECs4862 Z5482 732 Homologous recombination 488 Q8X7A1 Q8X7A1_ECO57 Fructose-1,6-bisphosphatase glpX ECs4850 Z5470 336 Glycolysis / Gluconeogenesis Pentose phosphate pathway Fructose and mannose metabolism 489 Q8X7B5 TRPA_ECO57 Tryptophan synthase alpha chain (EC 4.2.1.20) trpA Z2551 ECs1832 268 Glycine, serine and threonine metabolism Phenylalanine, tyrosine and tryptophan biosynthesis 490 Q8X7B6 TRPB_ECO57 Tryptophan synthase beta chain (EC 4.2.1.20) trpB Z2550 ECs1833 397 Glycine, serine and threonine metabolism Phenylalanine, tyrosine and tryptophan biosynthesis 491 Q8X7B7 TRPC_ECO57 Tryptophan biosynthesis protein TrpCF [Includes: Indole-3-glyceroltrpC phosphate Z2549 ECs1834 synthase (IGPS) (EC 4.1.1.48);452 Phenylalanine, N-(5'-phospho-ribosyl)anthranilate tyrosine and tryptophan isomerase biosynthesis (PRAI) (EC 5.3.1.24)] 492 Q8X7C2 Q8X7C2_ECO57 Cob(I)alamin adenolsyltransferase btuR ECs1842 Z2540 196 Porphyrin and chlorophyll metabolism 493 Q8X7C7 Q8X7C7_ECO57 Aconitate hydrase 1 acnA ECs1849 Z2532 891 Citrate cycle (TCA cycle) Glyoxylate and dicarboxylate metabolism 494 Q8X7E7 SYM_ECO57 Methionine--tRNA ligase (EC 6.1.1.10) (Methionyl-tRNA synthetase)metG (MetRS) Z3282 ECs2920 677 Selenocompound metabolism Aminoacyl-tRNA biosynthesis 495 Q8X7G5 Q8X7G5_ECO57 Phosphomethylpyrimidine kinase thiD ECs2906 Z3267 266 Thiamine metabolism 496 Q8X7G6 Q8X7G6_ECO57 Aldehyde dehydrogenase (Aldehyde dehydrogenase, prefers NADPaldH over ECs1877 NAD) Z2488 495 Arginine and proline metabolism 497 Q8X7N4 PROA_ECO57 Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehydeproA Z0304 ECs0270 dehydrogenase) (Glutamyl-gamma-semialdehyde417 Arginine and proline metabolism dehydrogenase) (GSA dehydrogenase) 498 Q8X7N8 Q8X7N8_ECO57 Aminoacyl-histidine dipeptidase (Peptidase D) (Aminoacyl-histidinepepD dipeptidase ECs0264 PepD)Z0298 485 Glutathione metabolism 499 Q8X7S3 Q8X7S3_ECO57 Molybdopterin biosynthesis (Molybdopterin biosynthesis MoeB protein)moeB ECs0904 Z1049 249 Sulfur relay system 500 Q8X7V7 Q8X7V7_ECO57 Putative ATP-dependent Clp proteinase ATP-binding chain (PutativeECs0223 protease) Z0254 923 Bacterial secretion system* 501 Q8X7X4 CYSD_ECO57 Sulfate adenylyltransferase subunit 2 (EC 2.7.7.4) (ATP-sulfurylasecysD small Z4060 subunit) ECs3606 (Sulfate adenylate transferase)302 Purine (SAT) metabolism Selenocompound metabolism Sulfur metabolism 502 Q8X7X7 CYSN_ECO57 Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4) (ATP-sulfurylasecysN large Z4059 subunit) ECs3605 (Sulfate adenylate transferase)475 Purine (SAT) metabolism Selenocompound metabolism Sulfur metabolism 503 Q8X7Y4 ISPD_ECO57 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60)ispD Z4055 (4-diphosphocytidyl-2C-methyl-D-erythritol ECs3601 236 Terpenoid synthase) backbone (MEP biosynthesis cytidylyltransferase) (MCT) 504 Q8X7Y5 Q8X7Y5_ECO57 DNA polymerase III epsilon subunit (DNA polymerase III, epsilondnaQ subunit) ECs0211 Z0241 243 Purine metabolism Pyrimidine metabolism DNA replication Mismatch repair Homologous recombination 505 Q8X7Y7 Q8X7Y7_ECO57 Putative ATP-dependent RNA helicase rhlE ECs0875 Z1017 455 RNA degradation 506 Q8X806 Q8X806_ECO57 Molybdopterin biosynthesis protein E chain (Molybdopterin convertingmoaE factor,ECs0863 subunit Z1004 2) 150 Folate biosynthesis Sulfur relay system 507 Q8X809 Q8X809_ECO57 Peptidoglycan synthetase (Peptidoglycan synthetase; penicillin-bindingmrcA proteinECs4238 1A) Z4750 858 Peptidoglycan biosynthesis* 508 Q8X824 AROB_ECO57 3-dehydroquinate synthase (EC 4.2.3.4) aroB Z4742 ECs4231 362 Phenylalanine, tyrosine and tryptophan biosynthesis 509 Q8X825 BIOB_ECO57 Biotin synthase (EC 2.8.1.6) bioB Z0994 ECs0853 346 Biotin metabolism 510 Q8X841 Q8X841_ECO57 6-phospho-beta-glucosidase (6-phospho-beta-glucosidase; cryptic)ascB ECs3572 Z4024 474 Glycolysis / Gluconeogenesis 511 Q8X862 Q8X862_ECO57 p-aminobenzoate synthetase component II (p-aminobenzoate synthetase,pabA ECs4211 component Z4721 II) 187 Folate biosynthesis 512 Q8X883 TUSD_ECO57 Sulfurtransferase TusD (EC 2.8.1.-) (tRNA 2-thiouridine synthesizingtusD protein Z4703 D)ECs4196 128 Sulfur relay system 513 Q8X884 TUSC_ECO57 Protein TusC (tRNA 2-thiouridine synthesizing protein C) tusC Z4702 ECs4195 119 Sulfur relay system 514 Q8X885 TUSB_ECO57 Protein TusB (tRNA 2-thiouridine synthesizing protein B) tusB Z4701 ECs4194 95 Sulfur relay system 515 Q8X8A1 RHAD_ECO57 Rhamnulose-1-phosphate aldolase (EC 4.1.2.19) rhaD Z5446 ECs4829 274 Pentose and glucuronate interconversions Fructose and mannose metabolism 516 Q8X8D9 Q8X8D9_ECO57 Spermidine/putrescine periplasmic transport protein potD ECs1499 Z1762 348 ABC transporters 517 Q8X8E1 NAGK_ECO57 N-acetyl-D-glucosamine kinase (EC 2.7.1.59) (GlcNAc kinase) nagK Z1760 ECs1497 303 Amino sugar and nucleotide sugar metabolism 518 Q8X8E2 Q8X8E2_ECO57 Putative kinase ycfW ECs1496 Z1759 414 ABC transporters 519 Q8X8E3 LOLD_ECO57 Lipoprotein-releasing system ATP-binding protein LolD (EC 3.6.3.-)lolD Z1758 ECs1495 233 ABC transporters 520 Q8X8F1 FMT_ECO57 Methionyl-tRNA formyltransferase (EC 2.1.2.9) fmt Z4658 ECs4153 315 One carbon pool by folate Aminoacyl-tRNA biosynthesis 521 Q8X8F9 AROE_ECO57 Shikimate dehydrogenase (EC 1.1.1.25) aroE Z4652 ECs4147 272 Phenylalanine, tyrosine and tryptophan biosynthesis 522 Q8X8H1 Q8X8H1_ECO57 DNA polymerase I polA ECs4786 Z5398 928 Purine metabolism Pyrimidine metabolism DNA replication Base excision repair Nucleotide excision repair Homologous recombination 523 Q8X8H5 Q8X8H5_ECO57 DNA polymerase III delta prime subunit (DNA polymerase III, deltaholB prime ECs1477 subunit) Z1738 334 Purine metabolism Pyrimidine metabolism DNA replication Mismatch repair Homologous recombination 524 Q8X8H6 KTHY_ECO57 Thymidylate kinase (EC 2.7.4.9) (dTMP kinase) tmk Z1737 ECs1476 213 Pyrimidine metabolism 525 Q8X8I2 FADB_ECO57 Fatty acid oxidation complex subunit alpha [Includes: Enoyl-CoAfadB hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA oldB Z5367 ECs4774 729 Butanoate isomerase/3-hydroxybutyryl-CoA metabolism epimerase (EC 4.2.1.17) (EC 5.1.2.3) (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)] 526 Q8X8I5 Q8X8I5_ECO57 3-oxoacyl-[acyl-carrier-protein] reductase fabG ECs1471 Z1732 244 Fatty acid biosynthesis Biosynthesis of unsaturated fatty acids 527 Q8X8I7 FABD_ECO57 Malonyl CoA-acyl carrier protein transacylase (MCT) (EC 2.3.1.39)fabD Z1731 ECs1470 309 Fatty acid biosynthesis 528 Q8X8J4 FADA_ECO57 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (Acetyl-CoA acyltransferase)fadA (Beta-ketothiolase) Z5366 ECs4773 (Fatty acid oxidation387 complexFatty acid subunit metabolism beta) Valine, leucine and isoleucine degradation alpha-Linolenic acid metabolism Geraniol degradation* Benzoate degradation* Ethylbenzene degradation* 529 Q8X8J5 Q8X8J5_ECO57 RNase E (RNase E, membrane attachment, mRNA turnover, maturationrne ECs1462 5S RNA) Z1722 1061 RNA degradation 530 Q8X8K4 YCJV_ECO57 Uncharacterized ABC transporter ATP-binding protein YcjV ycjV Z2463 ECs1897 360 ABC transporters 531 Q8X8L3 Q8X8L3_ECO57 Uridine phosphorylase udp ECs4761 Z5353 253 Pyrimidine metabolism 532 Q8X8L5 METE_ECO57 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferasemetE Z5351 (EC 2.1.1.14) ECs4759 (Cobalamin-independent753 Cysteine methionine and methioninesynthase) (Methionine metabolism synthase, vitamin-B12 independent isozyme) Selenocompound metabolism 533 Q8X8N1 Q8X8N1_ECO57 ATP-dependent DNA helicase recQ ECs4752 Z5343 611 RNA degradation 534 Q8X8N8 PYRC_ECO57 Dihydroorotase (DHOase) (EC 3.5.2.3) pyrC Z1699 ECs1440 348 Pyrimidine metabolism 535 Q8X8P5 Q8X8P5_ECO57 DNA-dependent ATPase I and helicase II uvrD ECs4743 Z5330 720 Nucleotide excision repair Mismatch repair 536 Q8X8T3 HISX_ECO57 Histidinol dehydrogenase (HDH) (EC 1.1.1.23) hisD Z3182 ECs2821 434 Histidine metabolism 537 Q8X8T4 HIS1_ECO57 ATP phosphoribosyltransferase (ATP-PRT) (ATP-PRTase) (EC 2.4.2.17)hisG Z3181 ECs2820 299 Histidine metabolism 538 Q8X8V9 METQ_ECO57 D-methionine-binding lipoprotein metQ metQ Z0209 ECs0199 271 ABC transporters 539 Q8X8W2 SYP_ECO57 Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)proS Z0206 ECs0196 572 Aminoacyl-tRNA biosynthesis 540 Q8X8X5 DPO3A_ECO57 DNA polymerase III subunit alpha (EC 2.7.7.7) dnaE Z0196 ECs0186 1160 Purine metabolism Pyrimidine metabolism DNA replication Mismatch repair Homologous recombination 541 Q8X8X6 RNH2_ECO57 Ribonuclease HII (RNase HII) (EC 3.1.26.4) rnhB Z0195 ECs0185 198 DNA replication 542 Q8X8X7 LPXB_ECO57 Lipid-A-disaccharide synthase (EC 2.4.1.182) lpxB Z0194 ECs0184 382 Lipopolysaccharide biosynthesis* 543 Q8X8X8 LPXA_ECO57 Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferaselpxA Z0193 (UDP-N-acetylglucosamine ECs0183 acyltransferase)262 Lipopolysaccharide (EC 2.3.1.129) biosynthesis* 544 Q8X8Y1 DXR_ECO57 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXP reductoisomerase)dxr Z0184 ECs0175(EC 1.1.1.267) (1-deoxyxylulose-5-phosphate398 Terpenoid backbone reductoisomerase) biosynthesis (2-C-methyl-D-erythritol 4-phosphate synthase) 545 Q8X8Y6 GLND_ECO57 [Protein-PII] uridylyltransferase (PII uridylyl-transferase) (EC 2.7.7.59)glnD Z0177 (UTase) ECs0169 (Uridylyl-removing enzyme)890 Two-component system* 546 Q8X8Y7 DAPD_ECO57 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferasedapD (EC Z01762.3.1.117) ECs0168 (Tetrahydrodipicolinate274 N-succinyltransferase)Lysine biosynthesis (THDP succinyltransferase) (THP succinyltransferase) (Tetrahydropicolinate succinylase) 547 Q8X8Z5 Q8X8Z5_ECO57 Ferrichrome-iron transport protein fhuB (Hydroxamate-dependentfhuB iron ECs0157uptake, cytoplasmic Z0164 membrane component)660 ABC transporters 548 Q8X8Z9 Q8X8Z9_ECO57 ATP-binding component of hydroxymate-dependent iron transportfhuC ECs0155 Z0162 265 ABC transporters 549 Q8X900 GSH1_ECO57 Glutamate--cysteine ligase (EC 6.3.2.2) (Gamma-ECS) (GCS) (Gamma-glutamylcysteinegshA Z3989 ECs3550 synthetase) 518 Glutathione metabolism 550 Q8X903 Q8X903_ECO57 Peptidoglycan synthetase MrcB (Peptidoglycan synthetase; penicillin-bindingmrcB ECs0153 protein Z0160 1B) 844 Peptidoglycan biosynthesis* 551 Q8X911 Q8X911_ECO57 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase)folK ECs0146 Z0153 160 Folate biosynthesis 552 Q8X914 Q8X914_ECO57 ATP-binding component of glycine betaine / proline transport systemproV (ATP-binding ECs3540 Z3979 component of transport400 systemABC fortransporters glycine, betaine and proline) 553 Q8X916 Q8X916_ECO57 Ribonucleoside-diphosphate reductase 2 beta chain (Ribonucleoside-diphosphatenrdF ECs3539 Z3978 reductase 2, beta chain) 319 Purine metabolism Pyrimidine metabolism 554 Q8X917 Q8X917_ECO57 Ribonucleoside-diphosphate reductase (EC 1.17.4.1) nrdE ECs3538 Z3977 714 Purine metabolism Pyrimidine metabolism 555 Q8X929 PANB_ECO57 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11)panB (Ketopantoate Z0145 ECs0138 hydroxymethyltransferase)264 (KPHMT)Pantothenate and CoA biosynthesis 556 Q8X930 PANC_ECO57 Pantothenate synthetase (PS) (EC 6.3.2.1) (Pantoate--beta-alaninepanC ligase) Z0144 (Pantoate-activating ECs0137 enzyme) 283 beta-Alanine metabolism Pantothenate and CoA biosynthesis 557 Q8X935 Q8X935_ECO57 Putative PTS enzyme II B component yadI ECs0133 Z0140 146 Ascorbate and aldarate metabolism Phosphotransferase system* 558 Q8X938 Q8X938_ECO57 Carbonic anhydrase (EC 4.2.1.1) yadF ECs0130 Z0137 220 Nitrogen metabolism* 559 Q8X942 Q8X942_ECO57 UDP-galactose-4-epimerase galE ECs0787 Z0929 338 Galactose metabolism Amino sugar and nucleotide sugar metabolism 560 Q8X943 Q8X943_ECO57 Galactose-1-phosphate uridylyltransferase (EC 2.7.7.12) galT ECs0786 Z0928 348 Galactose metabolism Amino sugar and nucleotide sugar metabolism 561 Q8X945 Q8X945_ECO57 Hypoxanthine phosphoribosyltransferase hpt ECs0129 Z0136 182 Purine metabolism 562 Q8X946 Q8X946_ECO57 Glucose dehydrogenase gcd ECs0128 Z0134 796 Pentose phosphate pathway 563 Q8X963 NADA_ECO57 Quinolinate synthase A (EC 2.5.1.72) nadA Z0919 ECs0778 347 Nicotinate and nicotinamide metabolism 564 Q8X966 Q8X966_ECO57 Pyruvate dehydrogenase (Dihydrolipoyltransacetylase component)aceF (Pyruvate ECs0119 dehydrogenase Z0125 dihydrolipoyltransacetylase630 Glycolysis component)/ Gluconeogenesis Citrate cycle (TCA cycle) Pyruvate metabolism 565 Q8X973 Q8X973_ECO57 Quinolinate phosphoribosyltransferase nadC ECs0113 Z0119 297 Nicotinate and nicotinamide metabolism 566 Q8X979 Q8X979_ECO57 Cytochrome d terminal oxidase polypeptide subunit I (CytochromecydA d terminal ECs0768 oxidase, Z0900 polypeptide subunit523 I) Oxidative phosphorylation Two-component system* 567 Q8X996 SECA_ECO57 Protein translocase subunit SecA secA Z0108 ECs0102 901 Protein export Bacterial secretion system* 568 Q8X9A0 Q8X9A0_ECO57 Putative transport system permease protein yhdY ECs4143 Z4631 368 ABC transporters 569 Q8X9A1 Q8X9A1_ECO57 Putative cob(I)alamin adenosyltransferase (Putative corrinoid:ATPECs0756 adenosyltransferase) Z0886 200 Porphyrin and chlorophyll metabolism 570 Q8X9A8 Q8X9A8_ECO57 Succinate dehydrogenase (Succinate dehydrogenase, iron sulfur protein)sdhB ECs0749 Z0878 238 Citrate cycle (TCA cycle) Oxidative phosphorylation Butanoate metabolism Toluene degradation* 571 Q8X9B6 ACCC_ECO57 Biotin carboxylase (EC 6.3.4.14) (Acetyl-CoA carboxylase subunitaccC A) (ACC)Z4616 (ECECs4128 6.4.1.2) 449 Fatty acid biosynthesis Pyruvate metabolism Propanoate metabolism 572 Q8X9E2 Q8X9E2_ECO57 Phospho-2-dehydro-3-deoxyheptonate aldolase (EC 2.5.1.54) (3-deoxy-D-arabino-heptulosonatearoF ECs3464 Z3893 7-phosphate356 synthase)Phenylalanine, (DAHP tyrosine synthase) and (Phospho-2-keto-3-deoxyheptonatetryptophan biosynthesis aldolase) 573 Q8X9F5 Q8X9F5_ECO57 Phosphatidylserine synthase (Phosphatidylserine synthase; phospholipidpssA ECs3452 synthesis) Z3870 452 Glycine, serine and threonine metabolism Glycerophospholipid metabolism 574 Q8X9F8 ATKA_ECO57 Potassium-transporting ATPase A chain (EC 3.6.3.12) (ATP phosphohydrolasekdpA Z0845 [potassium-transporting]ECs0726 A557 chain)Two-component (Potassium-binding system* and translocating subunit A) (Potassium-translocating ATPase A chain) 575 Q8X9G2 Q8X9G2_ECO57 Regulator of kdp operon (Transcriptional effector) (TranscriptionalkdpE regulator ECs0722 of kdp Z0841 operon) 225 Two-component system* 576 Q8X9G9 NANE_ECO57 Putative N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9)nanE (ManNAc-6-P Z4581 ECs4096 epimerase) 229 Amino sugar and nucleotide sugar metabolism 577 Q8X9H5 Q8X9H5_ECO57 Glutamate synthase small subunit (Glutamate synthase, small subunit)gltD ECs4092 Z4577 472 Alanine, aspartate and glutamate metabolism Nitrogen metabolism* 578 Q8X9H8 SYQ_ECO57 Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase)glnS (GlnRS)Z0827 ECs0710 554 Aminoacyl-tRNA biosynthesis 579 Q8X9I1 MTGA_ECO57 Monofunctional biosynthetic peptidoglycan transglycosylase (MonofunctionalmtgA Z4571 TGase)ECs4087 (EC 2.4.2.-) 242 Peptidoglycan biosynthesis* 580 Q8X9I8 Q8X9I8_ECO57 Phosphotransferase system enzyme IIA (Phosphotransferase systemptsN enzyme ECs4083 IIA, Z4567regulates N metabolism)163 Phosphotransferase system* 581 Q8X9I9 Q8X9I9_ECO57 RNA polymerase sigma-54 factor rpoN ECs4081 Z4565 477 Two-component system* 582 Q8X9J9 MURA_ECO57 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7)murA (Enoylpyruvate Z4552 ECs4068 transferase) (UDP-N-acetylglucosamine419 Amino sugar andenolpyruvyl nucleotide transferase) sugar metabolism (EPT) Peptidoglycan biosynthesis* 583 Q8X9K0 Q8X9K0_ECO57 Octaprenyl diphosphate synthase ispB ECs4066 Z4550 323 Terpenoid backbone biosynthesis 584 Q8X9K1 GHRA_ECO57 Glyoxylate/hydroxypyruvate reductase A (EC 1.1.1.79) (EC 1.1.1.81)ghrA (2-ketoacid Z1666 ECs1410 reductase) 312 Glycine, serine and threonine metabolism Pyruvate metabolism Glyoxylate and dicarboxylate metabolism 585 Q8X9K8 Q8X9K8_ECO57 D-alanyl-D-alanine carboxypeptidase (D-alanyl-D-alanine carboxypeptidase,dacB ECs4061 fraction Z4544 B; penicillin-binding477 proteinPeptidoglycan 4) biosynthesis* 586 Q8X9L1 Q8X9L1_ECO57 7,8-dihydropteroate synthase folP ECs4056 Z4539 297 Folate biosynthesis 587 Q8X9L2 GLMM_ECO57 Phosphoglucosamine mutase (EC 5.4.2.10) glmM Z4538 ECs4055 445 Amino sugar and nucleotide sugar metabolism 588 Q8X9M0 ASSY_ECO57 Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase)argG Z4534 ECs4052 447 Alanine, aspartate and glutamate metabolism Arginine and proline metabolism 589 Q8X9M2 RS15_ECO57 30S ribosomal protein S15 rpsO Z4526 ECs4046 89 Ribosome 590 Q8X9M3 PNP_ECO57 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) (Polynucleotidepnp Z4525 phosphorylase) ECs4045 (PNPase) 711 Purine metabolism Pyrimidine metabolism RNA degradation 591 Q8X9Q7 Q8X9Q7_ECO57 Fermentative D-lactate dehydrogenase (Fermentative D-lactate dehydrogenase,ldhA ECs2002 NAD-dependent) Z2329 329 Pyruvate metabolism 592 Q8X9U1 Q8X9U1_ECO57 Aldehyde dehydrogenase (Aldehyde dehydrogenase, NAD-linked)aldA ECs2021 Z2306 479 Pyruvate metabolism Glyoxylate and dicarboxylate metabolism 593 Q8X9U9 Q8X9U9_ECO57 Methyl-accepting chemotaxis protein III (Methyl-accepting chemotaxistrg ECs2026 protein Z2300 III, ribose sensor receptor)546 Two-component system* Bacterial chemotaxis* 594 Q8X9W5 ABDH_ECO57 Gamma-aminobutyraldehyde dehydrogenase (EC 1.2.1.19) (1-pyrrolineprr Z2275 dehydrogenase) ECs2048 (4-aminobutanal 474dehydrogenase)Arginine and (ABALDH) proline metabolism beta-Alanine metabolism 595 Q8X9W8 Q8X9W8_ECO57 Putative resistance protein ECs2052 Z2271 172 Phosphonate and phosphinate metabolism* 596 Q8X9Y1 Q8X9Y1_ECO57 Cryptic nitrate reductase 2 beta subunit (Cryptic nitrate reductase narY2, beta ECs2070 subunit) Z2245 514 Nitrogen metabolism* 597 Q8X9Y2 Q8X9Y2_ECO57 Cryptic nitrate reductase 2 alpha subunit (Cryptic nitrate reductasenarZ 2, alpha ECs2071 subunit) Z2244 1246 Nitrogen metabolism* 598 Q8X9Y6 DDLB_ECO57 D-alanine--D-alanine ligase B (EC 6.3.2.4) (D-Ala-D-Ala ligase B)ddlB (D-alanylalanine Z0102 ECs0096 synthetase B) 306 D-Alanine metabolism* Peptidoglycan biosynthesis* 599 Q8X9Y8 MURG_ECO57 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenolmurG Z0100 ECs0094 N-acetylglucosamine355 Peptidoglycan transferase biosynthesis* (EC 2.4.1.227) (Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase) 600 Q8X9Y9 MURD_ECO57 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) murD(D-glutamic Z0098 acid-addingECs0092 enzyme) (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate438 D-Glutamine and D-glutamate metabolism synthetase) Peptidoglycan biosynthesis* 601 Q8X9Z1 Q8X9Z1_ECO57 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (ECmurF 6.3.2.10) ECs0090 Z0096 452 Lysine biosynthesis Peptidoglycan biosynthesis* 602 Q8X9Z2 MURE_ECO57 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelatemurE ligase Z0095 (EC ECs0089 6.3.2.13) (Meso-A2pm-adding495 Lysine enzyme) biosynthesis (Meso-diaminopimelate-adding enzyme) (UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase) (UDP-MurNAc-tripeptide synthetase) (UDP-N-acetylmuramyl-tripeptide synthetase) Peptidoglycan biosynthesis* 603 Q8X9Z5 Q8X9Z5_ECO57 Acetolactate synthase III small subunit (Acetolactate synthase III, ilvHvaline ECs0082 sensitive, Z0088 small subunit) 163 Valine, leucine and isoleucine biosynthesis Butanoate metabolism Pantothenate and CoA biosynthesis C5-Branched dibasic acid metabolism* 604 Q8X9Z8 LEU1_ECO57 2-isopropylmalate synthase (EC 2.3.3.13) (Alpha-IPM synthase) (Alpha-isopropylmalateleuA Z0083 ECs0078 synthase) 523 Valine, leucine and isoleucine biosynthesis Pyruvate metabolism 605 Q8X9Z9 LEU3_ECO57 3-isopropylmalate dehydrogenase (EC 1.1.1.85) (3-IPM-DH) (Beta-IPMleuB Z0082 dehydrogenase) ECs0077 (IMDH) 363 Valine, leucine and isoleucine biosynthesis 606 Q8XA00 LEUC_ECO57 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) (Alpha-IPMleuC Z0081 isomerase) ECs0076 (IPMI) (Isopropylmalate466 isomerase)Valine, leucine and isoleucine biosynthesis C5-Branched dibasic acid metabolism* 607 Q8XA01 LEUD_ECO57 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) (Alpha-IPMleuD Z0080 isomerase) ECs0075 (IPMI) (Isopropylmalate201 isomerase)Valine, leucine and isoleucine biosynthesis C5-Branched dibasic acid metabolism* 608 Q8XA05 Q8XA05_ECO57 Putative transport system permease protein yabK ECs0071 Z0076 536 ABC transporters 609 Q8XA06 THIQ_ECO57 Thiamine import ATP-binding protein ThiQ (EC 3.6.3.-) thiQ Z0075 ECs0070 232 ABC transporters 610 Q8XA18 Q8XA18_ECO57 Dihydrofolate reductase (EC 1.5.1.3) ECs0051 Z0055 159 One carbon pool by folate Folate biosynthesis 611 Q8XA23 NADB_ECO57 L-aspartate oxidase (LASPO) (EC 1.4.3.16) (Quinolinate synthasenadB B) Z3856 ECs3440 540 Alanine, aspartate and glutamate metabolism Nicotinate and nicotinamide metabolism 612 Q8XA27 FIXB_ECO57 Protein fixB fixB Z0048 ECs0045 313 Nitrogen metabolism* 613 Q8XA33 Q8XA33_ECO57 Signal peptidase I (EC 3.4.21.89) lepB ECs3434 Z3850 324 Protein export 614 Q8XA39 ACPS_ECO57 Holo-[acyl-carrier-protein] synthase (Holo-ACP synthase) (EC 2.7.8.7)acpS dpj(4'-phosphopantetheinyl Z3844 ECs3429 transferase126 AcpS)Pantothenate and CoA biosynthesis 615 Q8XA46 PUR4_ECO57 Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS)purL Z3835 (EC ECs3423 6.3.5.3) (Formylglycinamide1295 ribotidePurine metabolism amidotransferase) (FGARAT) (Formylglycinamide ribotide synthetase) 616 Q8XA48 LSPA_ECO57 Lipoprotein signal peptidase (EC 3.4.23.36) (Prolipoprotein signallspA peptidase) Z0031 (SignalECs0030 peptidase II) (SPase164 II) Protein export 617 Q8XA49 SYI_ECO57 Isoleucine--tRNA ligase (EC 6.1.1.5) (Isoleucyl-tRNA synthetase)ileS (IleRS) Z0030 ECs0029 938 Aminoacyl-tRNA biosynthesis 618 Q8XA55 GLYA_ECO57 Serine hydroxymethyltransferase (SHMT) (Serine methylase) (ECglyA 2.1.2.1) Z3827 ECs3417 417 Glycine, serine and threonine metabolism Cyanoamino acid metabolism Glyoxylate and dicarboxylate metabolism One carbon pool by folate Methane metabolism* 619 Q8XA73 HCAF_ECO57 3-phenylpropionate/cinnamic acid dioxygenase subunit beta (EC 1.14.12.19)hcaF Z3810 (Digoxigenin ECs3405 subunit beta) 172 Phenylalanine metabolism 620 Q8XA80 Q8XA80_ECO57 Threonine synthase thrC ECs0004 Z0004 428 Glycine, serine and threonine metabolism Vitamin B6 metabolism 621 Q8XA84 Q8XA84_ECO57 Aspartokinase I, homoserine dehydrogenase I (Aspartokinase I-homoserinethrA ECs0002 dehydrogenase Z0002 I) 820 Glycine, serine and threonine metabolism Cysteine and methionine metabolism Lysine biosynthesis 622 Q8XA87 DEAD_ECO57 Cold-shock DEAD box protein A (EC 3.6.4.13) (ATP-dependent RNAdeaD helicase Z4523 ECs4043 deaD) 629 RNA degradation 623 Q8XAB8 Q8XAB8_ECO57 Galactosamine-specific PTS system enzyme IIB component (PTS agaBsystem, ECs4018 cytoplasmic, Z4492 N-acetylgalactosamine-specific158 Galactose IIB metabolism component 1 (EIIB-AGA)) Phosphotransferase system* 624 Q8XAC5 PUR5_ECO57 Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRpurM synthase) Z3762 (AIRS)ECs3361 (Phosphoribosyl-aminoimidazole345 Purine metabolism synthetase) 625 Q8XAF1 TDCD_ECO57 Propionate kinase (EC 2.7.2.15) tdcD Z4467 ECs3995 402 Propanoate metabolism 626 Q8XAF2 Q8XAF2_ECO57 Probable formate acetyltransferase 3 (Putative formate acetyltransferasetdcE ECs3994 3) Z4466 764 Pyruvate metabolism Propanoate metabolism Butanoate metabolism 627 Q8XAG0 URE1_ECO57 Urease subunit alpha (EC 3.5.1.5) (Urea amidohydrolase subunit alpha)ureC1 Z1145 ECs1324; ureC2 Z1584 568 Purine metabolism Arginine and proline metabolism 628 Q8XAG1 URE2_ECO57 Urease subunit beta (EC 3.5.1.5) (Urea amidohydrolase subunit beta)ureB1 Z1144 ECs1323; ureB2 Z1583 106 Purine metabolism Arginine and proline metabolism 629 Q8XAG2 URE3_ECO57 Urease subunit gamma (EC 3.5.1.5) (Urea amidohydrolase subunitureA1 gamma) Z1143 ECs1322; ureA2 Z1582 100 Purine metabolism Arginine and proline metabolism 630 Q8XAG6 Q8XAG6_ECO57 Putative diacylglycerol kinase ECs1316 Z1139 Z1578 119 Glycerolipid metabolism Glycerophospholipid metabolism 631 Q8XAN1 PAT_ECO57 Putrescine aminotransferase (EC 2.6.1.82) (Putrescine--2-oxoglutaricpatA acid Z4426 transaminase) ECs3955 (PAT) (PATase) 459 Arginine and proline metabolism 632 Q8XAP1 CYAA_ECO57 Adenylate cyclase (EC 4.6.1.1) (ATP pyrophosphate-lyase) (AdenylylcyaA cyclase) Z5322 ECs4736 848 Purine metabolism 633 Q8XAP3 HEM3_ECO57 Porphobilinogen deaminase (PBG) (EC 2.5.1.61) (HydroxymethylbilanehemC Z5319 synthase) ECs4735 (HMBS) (Pre-uroporphyrinogen313 Porphyrin synthase) and chlorophyll metabolism 634 Q8XAP5 Q8XAP5_ECO57 Uroporphyrinogen III synthase hemD ECs4734 Z5318 246 Porphyrin and chlorophyll metabolism 635 Q8XAP7 Q8XAP7_ECO57 Uroporphyrinogen III methylase hemX ECs4733 Z5317 399 Porphyrin and chlorophyll metabolism 636 Q8XAR4 Q8XAR4_ECO57 Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) rffH ECs4722 Z5300 293 Streptomycin biosynthesis* Polyketide sugar unit biosynthesis* 637 Q8XAR8 WECB_ECO57 UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) (BacteriophagewecB N4 nfrC adsorption rffE Z5297 protein ECs4719 C) (UDP-GlcNAc-2-epimerase)376 Amino sugar and nucleotide sugar metabolism 638 Q8XAT4 RHLB_ECO57 ATP-dependent RNA helicase rhlB (EC 3.6.4.13) rhlB Z5290 ECs4713 421 RNA degradation 639 Q8XAT5 GPPA_ECO57 Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC 3.6.1.40)gppA Z5289 (Guanosine ECs4712 pentaphosphate phosphohydrolase)494 Purine metabolism (pppGpp-5'-phosphohydrolase) 640 Q8XAV1 ILVD_ECO57 Dihydroxy-acid dehydratase (DAD) (EC 4.2.1.9) ilvD Z5282 ECs4705 616 Valine, leucine and isoleucine biosynthesis Pantothenate and CoA biosynthesis 641 Q8XAV4 Q8XAV4_ECO57 Acetolactate synthase (EC 2.2.1.6) ilvG ECs4702 Z5279 548 Valine, leucine and isoleucine biosynthesis Butanoate metabolism Pantothenate and CoA biosynthesis C5-Branched dibasic acid metabolism* 642 Q8XAW7 RBSA1_ECO57 Ribose import ATP-binding protein RbsA 1 (EC 3.6.3.17) rbsA1 Z5250 ECs4691 501 ABC transporters 643 Q8XB03 Q8XB03_ECO57 High-affinity phosphate-specific transport system; periplasmic phosphate-bindingpstS ECs4664 Z5219 protein (Phosphate-binding346 periplasmicABC transporters protein PstS) Two-component system* 644 Q8XB09 Q8XB09_ECO57 Catabolic regulation response regulator creB ECs5356 Z6001 229 Two-component system* 645 Q8XB47 Q8XB47_ECO57 DNA polymerase III psi subunit (DNA polymerase III, psi subunit)holD ECs5330 Z5973 137 Purine metabolism Pyrimidine metabolism DNA replication Mismatch repair Homologous recombination 646 Q8XB55 DNAT_ECO57 Primosomal protein 1 (Primosomal protein I) dnaT Z5962 ECs5322 179 Homologous recombination 647 Q8XB75 HIUH_ECO57 5-hydroxyisourate hydrolase (HIU hydrolase) (HIUHase) (EC 3.5.2.17)hiuH Z3062 (Transthyretin-like ECs2708 protein) (TLP)137 Purine metabolism 648 Q8XBA3 Q8XBA3_ECO57 Flagellar biosynthesis, component of motor switch and energizing,fliN enabling ECs2685 rotation Z3036 and determining its direction137 Bacterial (Flagellar chemotaxis* motor switch protein FliN) Flagellar assembly* 649 Q8XBA8 Q8XBA8_ECO57 Flagellar fliJ protein fliJ ECs2681 Z3032 147 Flagellar assembly* 650 Q8XBC8 Q8XBC8_ECO57 Putative transport system permease protein (Putative transport systemyecS permease ECs2656 protein Z3006 (Former yecC)) 222 ABC transporters 651 Q8XBC9 Q8XBC9_ECO57 Putative ATP-binding component of a transport system yecC ECs2655 Z3005 250 ABC transporters 652 Q8XBE0 DAPE_ECO57 Succinyl-diaminopimelate desuccinylase (SDAP desuccinylase) (ECdapE 3.5.1.18) Z3730 ECs3334(N-succinyl-LL-2,6-diaminoheptanedioate375 Lysine biosynthesis amidohydrolase) 653 Q8XBG3 Q8XBG3_ECO57 Ethanolamine utilization protein EutI (Ethanolamine utilization; homologeutI ECs3320 of Salmonella Z3714 acetyl/butyryl P transferase)338 Pyruvate metabolism 654 Q8XBI4 HEM6_ECO57 Coproporphyrinogen-III oxidase, aerobic (Coprogen oxidase) (Coproporphyrinogenase)hemF Z3701 ECs3307 (EC 1.3.3.3) 299 Porphyrin and chlorophyll metabolism 655 Q8XBJ6 Q8XBJ6_ECO57 Sulfate transport system permease T protein (Sulfate, thiosulfate transportcysU ECs3295 system Z3689 permease T protein) 277 ABC transporters 656 Q8XBJ8 CYSA_ECO57 Sulfate/thiosulfate import ATP-binding protein CysA (EC 3.6.3.25)cysA (Sulfate-transporting Z3687 ECs3293 ATPase) 365 ABC transporters 657 Q8XBL0 PDXK_ECO57 Pyridoxine kinase (EC 2.7.1.35) (PN/PL/PM kinase) (Pyridoxal kinase)pdxK Z3684(Pyridoxamine ECs3290 kinase) (Vitamin B6283 kinase)Vitamin B6 metabolism 658 Q8XBL1 Q8XBL1_ECO57 Glucose-specific PTS system IIA component (PTS system, glucose-specificcrr ECs3289 IIA Z3683 component) 169 Glycolysis / Gluconeogenesis Starch and sucrose metabolism Amino sugar and nucleotide sugar metabolism Phosphotransferase system* 659 Q8XBL2 Q8XBL2_ECO57 Putative kinase ygiG ECs3941 Z4411 123 Folate biosynthesis 660 Q8XBL3 Q8XBL3_ECO57 Phosphoenolpyruvate-protein phosphotransferase (EC 2.7.3.9) (PhosphotransferaseptsI ECs3288 Z3682 system, enzyme I) 575 Phosphotransferase system* 661 Q8XBL5 DNLJ_ECO57 DNA ligase (EC 6.5.1.2) (Polydeoxyribonucleotide synthase [NAD(+)])ligA Z3677 ECs3283 671 DNA replication Base excision repair Nucleotide excision repair Mismatch repair 662 Q8XBN2 SYE_ECO57 Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase)gltX (GluRS) Z3665 ECs3278 471 Porphyrin and chlorophyll metabolism Aminoacyl-tRNA biosynthesis 663 Q8XBN8 SYL_ECO57 Leucine--tRNA ligase (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS)leuS Z0789 ECs0680 860 Aminoacyl-tRNA biosynthesis 664 Q8XBP0 NADD_ECO57 Nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) (Deamido-NAD(+)nadD Z0786 diphosphorylase) ECs0677 (Deamido-NAD(+)213 Nicotinate pyrophosphorylase) and nicotinamide (Nicotinate metabolism mononucleotide adenylyltransferase) (NaMN adenylyltransferase) 665 Q8XBQ6 Q8XBQ6_ECO57 Putative ABC-type iron-siderophore transport system ATP-bindingECs3916 protein (PutativeZ4385 ATP-binding protein 269of ABCABC transporter transporters family) 666 Q8XBQ7 Q8XBQ7_ECO57 Putative iron compound permease protein of ABC transporter familyECs3915 (Putative Z4384 permease of ferrichrome ABC327 transporter)ABC transporters 667 Q8XBS3 QSEB_ECO57 Transcriptional regulatory protein qseB qseB Z4377 ECs3907 219 Two-component system* 668 Q8XBS5 Q8XBS5_ECO57 1-acyl-sn-glycerol-3-phosphate acyltransferase plsC ECs3902 Z4372 245 Glycerolipid metabolism Glycerophospholipid metabolism 669 Q8XBV5 Q8XBV5_ECO57 Ferric enterobactin (Enterochelin) transport fepD ECs0629 Z0732 334 ABC transporters 670 Q8XBV6 Q8XBV6_ECO57 Ferric enterobactin transport protein fepG ECs0628 Z0731 330 ABC transporters 671 Q8XBV7 Q8XBV7_ECO57 ATP-binding component of ferric enterobactin transport fepC ECs0627 Z0729 271 ABC transporters 672 Q8XBZ3 DNAA_ECO57 Chromosomal replication initiator protein DnaA dnaA Z5193 ECs4637 467 Two-component system* 673 Q8XC30 Q8XC30_ECO57 Probable third cytochrome oxidase subunit II (Probable third cytochromeappB ECs1135 oxidase, Z1396 subunit II) 378 Oxidative phosphorylation Two-component system* 674 Q8XC31 Q8XC31_ECO57 Probable third cytochrome oxidase subunit I (Probable third cytochromeappC ECs1134 oxidase, Z1395subunit I) 514 Oxidative phosphorylation Two-component system* 675 Q8XC50 NLPA_ECO57 Lipoprotein 28 nlpA Z5147 ECs4595 272 ABC transporters 676 Q8XCA4 Q8XCA4_ECO57 Putative uncharacterized protein ECs5239 (Putative uncharacterizedyjgQ protein ECs5239 yjgQ) Z5874 361 ABC transporters 677 Q8XCB1 Q8XCB1_ECO57 DNA polymerase III chi subunit (DNA polymerase III, chi subunit)holC ECs5236 Z5871 147 Purine metabolism Pyrimidine metabolism DNA replication Mismatch repair Homologous recombination 678 Q8XCB3 SYV_ECO57 Valine--tRNA ligase (EC 6.1.1.9) (Valyl-tRNA synthetase) (ValRS)valS Z5870 ECs5235 951 Aminoacyl-tRNA biosynthesis 679 Q8XCB8 OTC_ECO57 Ornithine carbamoyltransferase (OTCase) (EC 2.1.3.3) argI Z5866 ECs5231 334 Arginine and proline metabolism 680 Q8XCC1 Q8XCC1_ECO57 Putative uncharacterized protein ECs1753 (Putative uncharacterizedyciA protein ECs1753 yciA) Z2031 132 Biosynthesis of unsaturated fatty acids 681 Q8XCE1 Q8XCE1_ECO57 Trehalase 6-P hydrolase treC ECs5216 Z5849 551 Starch and sucrose metabolism 682 Q8XCE2 Q8XCE2_ECO57 Anaerobic ribonucleoside-triphosphate reductase nrdD ECs5215 Z5848 712 Pyrimidine metabolism 683 Q8XCE9 Q8XCE9_ECO57 Proton conductor component of motor (Proton conductor componentmotA of ECs2600motor; no Z2944 effect on switching) 295 Two-component system* Bacterial chemotaxis* Flagellar assembly* 684 Q8XCF0 F16PA_ECO57 Fructose-1,6-bisphosphatase class 1 (FBPase class 1) (EC 3.1.3.11)fbp (D-fructose-1,6-bisphosphate Z5842 ECs5209 1-phosphohydrolase332 Glycolysis class / Gluconeogenesis 1) Pentose phosphate pathway Fructose and mannose metabolism Methane metabolism* 685 Q8XCF5 Q8XCF5_ECO57 Sensory transducer kinase CheA (Sensory transducer kinase betweencheA chemo-signal ECs2598 Z2942 receptors and CheB and654 CheY)Two-component system* Bacterial chemotaxis* 686 Q8XCF7 Q8XCF7_ECO57 Methyl-accepting chemotaxis protein IV (Methyl-accepting chemotaxistap ECs2595 protein Z2939 IV, peptide sensor receptor)533 Two-component system* Bacterial chemotaxis* 687 Q8XCF8 Q8XCF8_ECO57 Response regulator for chemotaxis (Response regulator for chemotaxis;cheR ECs2594 protein glutamate Z2938 methyltransferase)286 Two-component system* Bacterial chemotaxis* 688 Q8XCG7 Q8XCG7_ECO57 2':3'-cyclic-nucleotide 2'-phosphodiesterase cpdB ECs5191 Z5824 647 Purine metabolism Pyrimidine metabolism 689 Q8XCH2 SYR_ECO57 Arginine--tRNA ligase (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS)argS Z2929 ECs2586 577 Aminoacyl-tRNA biosynthesis 690 Q8XCI7 SYD_ECO57 Aspartate--tRNA ligase (EC 6.1.1.12) (Aspartyl-tRNA synthetase)aspS (AspRS) Z2919 ECs2576 590 Aminoacyl-tRNA biosynthesis 691 Q8XCJ1 Q8XCJ1_ECO57 Putative adhesin yebL ECs2567 Z2909 328 ABC transporters 692 Q8XCJ3 Q8XCJ3_ECO57 Heat shock protein MsbB (Suppressor of htrB, heat shock protein)msbB ECs2565 Z2907 323 Lipopolysaccharide biosynthesis* 693 Q8XCJ6 G6PD_ECO57 Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) zwf Z2904 ECs2562 491 Pentose phosphate pathway Glutathione metabolism 694 Q8XCR0 PDXB_ECO57 Erythronate-4-phosphate dehydrogenase (EC 1.1.1.290) pdxB Z3582 ECs3204 378 Vitamin B6 metabolism 695 Q8XCR3 Q8XCR3_ECO57 Dihydrofolate:folylpolyglutamate synthetase (Dihydrofolate:folylpolyglutamatefolC ECs3199 synthetase;Z3577 dihydrofolate422 synthetase)Folate biosynthesis 696 Q8XCR6 Q8XCR6_ECO57 Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (GlutaminepurF phosphoribosylpyrophosphate ECs3196 Z3574 amidotransferase)505 Purine metabolism Alanine, aspartate and glutamate metabolism 697 Q8XCT6 FOLD_ECO57 Bifunctional protein FolD [Includes: Methylenetetrahydrofolate dehydrogenasefolD Z0684 ECs0591 (EC 1.5.1.5); Methenyltetrahydrofolate288 One carbon cyclohydrolase pool by folate (EC 3.5.4.9)] 698 Q8XCT9 SYC_ECO57 Cysteine--tRNA ligase (EC 6.1.1.16) (Cysteinyl-tRNA synthetase)cysS (CysRS) Z0681 ECs0588 461 Aminoacyl-tRNA biosynthesis 699 Q8XCU1 LPXH_ECO57 UDP-2,3-diacylglucosamine hydrolase (EC 3.6.1.54) (UDP-2,3-diacylglucosaminelpxH Z0679 ECs0586 diphosphatase) 240 Lipopolysaccharide biosynthesis* 700 Q8XCU2 Q8XCU2_ECO57 Periplasmic L-asparaginase II ansB ECs3833 Z4302 348 Alanine, aspartate and glutamate metabolism Cyanoamino acid metabolism Nitrogen metabolism* 701 Q8XCU5 RDGB_ECO57 dITP/XTP pyrophosphatase (EC 3.6.1.19) (Non-canonical purine NTPrdgB pyrophosphatase)yggV Z4299 ECs3830 (Non-standard purine197 Purine NTP pyrophosphatase) metabolism (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) Pyrimidine metabolism 702 Q8XCU8 Q8XCU8_ECO57 Phosphate acetyltransferase (EC 2.3.1.8) (Phosphotransacetylase)pta ECs3181 Z3559 714 Taurine and hypotaurine metabolism Pyruvate metabolism Propanoate metabolism Methane metabolism* 703 Q8XCV4 Q8XCV4_ECO57 Phosphoribosylaminoimidazole carboxylase (PhosphoribosylaminoimidazolepurK ECs0584 carboxylase Z0677 = AIR carboxylase,355 PurineCO(2)-fixing metabolism subunit) 704 Q8XCV5 ARCC_ECO57 Carbamate kinase (EC 2.7.2.2) arcC Z0676 ECs0583 297 Purine metabolism Arginine and proline metabolism Nitrogen metabolism* 705 Q8XCW0 Q8XCW0_ECO57 Glycerate kinase (Putative uncharacterized protein ybbZ) ybbZ ECs0576 Z0669 381 Glycine, serine and threonine metabolism Glycerolipid metabolism Glyoxylate and dicarboxylate metabolism 706 Q8XCW5 Q8XCW5_ECO57 Putative aminotransferase ECs3174 Z3551 405 Alanine, aspartate and glutamate metabolism Valine, leucine and isoleucine biosynthesis 707 Q8XCW9 NUOCD_ECO57 NADH-quinone oxidoreductase subunit C/D (EC 1.6.99.5) (NADHnuoC dehydrogenase nuoCD nuoD I subunit Z3545 ECs3170C/D) (NDH-1600 subunitNitrogen C/D) metabolism* 708 Q8XCX1 Q8XCX1_ECO57 NADH dehydrogenase I chain F nuoF ECs3168 Z3543 445 Oxidative phosphorylation Nitrogen metabolism* 709 Q8XCX7 Q8XCX7_ECO57 Glyoxylate-induced protein (Hydroxypyruvate isomerase) gip ECs0569 Z0662 258 Glyoxylate and dicarboxylate metabolism 710 Q8XCY3 Q8XCY3_ECO57 NADH dehydrogenase I chain L nuoL ECs3162 Z3537 613 Oxidative phosphorylation Nitrogen metabolism* 711 Q8XD03 PGK_ECO57 Phosphoglycerate kinase (EC 2.7.2.3) pgk Z4265 ECs3797 387 Glycolysis / Gluconeogenesis 712 Q8XD32 GCST_ECO57 Aminomethyltransferase (EC 2.1.2.10) (Glycine cleavage system TgcvT protein) Z4242 ECs3776 364 Glycine, serine and threonine metabolism One carbon pool by folate Nitrogen metabolism* 713 Q8XD33 GCSP_ECO57 Glycine dehydrogenase [decarboxylating] (EC 1.4.4.2) (Glycine cleavagegcvP Z4240 system ECs3774 P-protein) (Glycine decarboxylase)957 Glycine, serine and threonine metabolism 714 Q8XD39 HEMH_ECO57 Ferrochelatase (EC 4.99.1.1) (Heme synthase) (Protoheme ferro-lyase)hemH Z0592 ECs0528 320 Porphyrin and chlorophyll metabolism 715 Q8XD46 Q8XD46_ECO57 DNA polymerase III tau and gamma subunits (DNA polymerase III,dnaX tau ECs0523and gamma Z0587 subunits; DNA elongation643 Purine factor metabolismIII) Pyrimidine metabolism DNA replication Mismatch repair Homologous recombination 716 Q8XD48 APT_ECO57 Adenine phosphoribosyltransferase (APRT) (EC 2.4.2.7) apt Z0586 ECs0522 183 Purine metabolism 717 Q8XD57 SYK1_ECO57 Lysine--tRNA ligase (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS)lysS Z4228 ECs3762 505 Aminoacyl-tRNA biosynthesis 718 Q8XD78 Q8XD78_ECO57 Carbamate kinase yqeA ECs3747 Z4213 310 Purine metabolism Arginine and proline metabolism 719 Q8XD82 TUSE_ECO57 Sulfurtransferase TusE (EC 2.8.1.-) (tRNA 2-thiouridine synthesizingtusE protein Z1321 E)ECs1053 109 Sulfur relay system 720 Q8XD86 RECG_ECO57 ATP-dependent DNA helicase recG (EC 3.6.4.12) recG Z5078 ECs4527 693 Homologous recombination 721 Q8XD88 KGUA_ECO57 Guanylate kinase (EC 2.7.4.8) (GMP kinase) gmk Z5074 ECs4523 207 Purine metabolism 722 Q8XD99 PYRE_ECO57 Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10)pyrE Z5066 ECs4517 213 Pyrimidine metabolism 723 Q8XDA2 Q8XDA2_ECO57 Flavoprotein affecting synthesis of DNA and pantothenate metabolismdfp ECs4514 (Pantothenate Z5063 metabolism flavoprotein430 PantothenateDfp) and CoA biosynthesis 724 Q8XDB7 Q8XDB7_ECO57 Glucosyltransferase I (Glucosyltransferase I; lipopolysaccharide corerfaG biosynthesis) ECs4506 Z5055 374 Lipopolysaccharide biosynthesis* 725 Q8XDC6 Q8XDC6_ECO57 Nitrate reductase 1 beta subunit (Nitrate reductase 1, beta subunit)narH ECs1730 Z2002 512 Nitrogen metabolism* Two-component system* 726 Q8XDC8 Q8XDC8_ECO57 Nitrate reductase 1 alpha subunit (Nitrate reductase 1, alpha subunit)narG ECs1729 Z2001 1247 Nitrogen metabolism* Two-component system* 727 Q8XDD3 Q8XDD3_ECO57 Heptosyl transferase I (Heptosyl transferase I; lipopolysaccharide rfaCcore ECs4499biosynthesis) Z5048 330 Lipopolysaccharide biosynthesis* 728 Q8XDD5 Q8XDD5_ECO57 ADP-heptose--lps heptosyltransferase II (ADP-heptose--lps heptosyltransferaserfaF ECs4498 II;Z5047 lipopolysaccharide core348 biosynthesis)Lipopolysaccharide biosynthesis* 729 Q8XDE7 KDSA_ECO57 2-dehydro-3-deoxyphosphooctonate aldolase (EC 2.5.1.55) (3-deoxy-D-manno-octulosonickdsA Z1986 ECs1720 acid 8-phosphate284 synthase)Lipopolysaccharide (KDO-8-phosphate biosynthesis* synthase) (KDO 8-P synthase) (KDOPS) (Phospho-2-dehydro-3-deoxyoctonate aldolase) 730 Q8XDE9 GPMI_ECO57 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (BPG-independentgpmI Z5039 ECs4490 PGAM) (Phosphoglyceromutase)514 Glycolysis (iPGM) / Gluconeogenesis (EC 5.4.2.1) Glycine, serine and threonine metabolism Methane metabolism* 731 Q8XDF1 Q8XDF1_ECO57 Outer membrane protein 1a (Outer membrane protein 1a (Ia;b;F))ompF ECs1012 Z1276 362 Two-component system* 732 Q8XDF3 Q8XDF3_ECO57 Aspartate aminotransferase aspC ECs1011 Z1275 396 Alanine, aspartate and glutamate metabolism Cysteine and methionine metabolism Arginine and proline metabolism Tyrosine metabolism Phenylalanine metabolism Phenylalanine, tyrosine and tryptophan biosynthesis Novobiocin biosynthesis* 733 Q8XDG6 KDSB_ECO57 3-deoxy-manno-octulosonate cytidylyltransferase (EC 2.7.7.38) (CMP-2-keto-3-deoxyoctulosonickdsB Z1264 ECs1001 acid synthase)248 Lipopolysaccharide (CKS) (CMP-KDO biosynthesis* synthase) 734 Q8XDH0 LPXK_ECO57 Tetraacyldisaccharide 4'-kinase (EC 2.7.1.130) (Lipid A 4'-kinase)lpxK Z1261 ECs0998 328 Lipopolysaccharide biosynthesis* 735 Q8XDH5 Q8XDH5_ECO57 Dihydroxyacetone kinase (Putative dihydroxyacetone kinase) (ECECs1704 2.7.1.2) Z1970 210 Glycerolipid metabolism 736 Q8XDI9 Q8XDI9_ECO57 Putative oxidoreductase yiaY ECs4466 Z5010 383 Glycolysis / Gluconeogenesis Fatty acid metabolism Tyrosine metabolism Chloroalkane and chloroalkene degradation* Naphthalene degradation* Nitrotoluene degradation* 737 Q8XDJ5 ULAA_ECO57 Ascorbate-specific permease IIC component ulaA (Ascorbate-specificulaA PTSZ5802 system ECs5169 EIIC component) 465 Ascorbate and aldarate metabolism Phosphotransferase system* 738 Q8XDL9 Q8XDL9_ECO57 Ribonuclease R (RNase R) (EC 3.1.13.1) vacB rnr ECs5155 Z5786 827 RNA degradation 739 Q8XDM1 XYLG_ECO57 Xylose import ATP-binding protein XylG (EC 3.6.3.17) xylG Z4992 ECs4450 513 ABC transporters 740 Q8XDM4 Q8XDM4_ECO57 Xylulokinase xylB ECs4447 Z4989 484 Pentose and glucuronate interconversions 741 Q8XDN4 MUTL_ECO57 DNA mismatch repair protein mutL mutL Z5777 ECs5146 615 Mismatch repair 742 Q8XDQ0 Q8XDQ0_ECO57 Flavoprotein subunit of fumarate reductase FrdA (Fumarate reductase,frdA anaerobic,ECs5135 Z5762 flavoprotein subunit) 602 Citrate cycle (TCA cycle) Oxidative phosphorylation Butanoate metabolism Toluene degradation* Two-component system* 743 Q8XDS0 ASPA_ECO57 Aspartate ammonia-lyase (Aspartase) (EC 4.3.1.1) aspA Z5744 ECs5120 478 Alanine, aspartate and glutamate metabolism Nitrogen metabolism* 744 Q8XDS4 Q8XDS4_ECO57 Putative tartrate dehydrogenase yeaU ECs2509 Z2843 361 Glyoxylate and dicarboxylate metabolism Butanoate metabolism 745 Q8XDU4 Q8XDU4_ECO57 2-component regulatory system regulatory protein BasR (TranscriptionalbasR ECs5095 regulatory Z5715 protein 2-component 222regulatoryTwo-component system member) system* 746 Q8XDV7 PHNC_ECO57 Phosphonates import ATP-binding protein PhnC (EC 3.6.3.28) phnC Z5708 ECs5088 262 ABC transporters 747 Q8XDX8 MEND_ECO57 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylatemenD synthase Z3524 (SEPHCHC ECs3152 synthase) (EC 2.2.1.9)556 Ubiquinone (Menaquinone and otherbiosynthesis terpenoid-quinone protein MenD) biosynthesis 748 Q8XDX9 MENH_ECO57 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase menH(SHCHC Z3523 synthase) ECs3151 (EC 4.2.99.20) 252 Ubiquinone and other terpenoid-quinone biosynthesis 749 Q8XDY5 Q8XDY5_ECO57 Exonuclease III xthA ECs2455 Z2781 268 Base excision repair 750 Q8XDZ9 NADE_ECO57 NH(3)-dependent NAD(+) synthetase (EC 6.3.1.5) nadE Z2770 ECs2446 275 Nicotinate and nicotinamide metabolism 751 Q8XE07 RHMD_ECO57 L-rhamnonate dehydratase (RhamD) (EC 4.2.1.90) rhmD Z3505 ECs3135 405 Fructose and mannose metabolism 752 Q8XE13 GLPB_ECO57 Anaerobic glycerol-3-phosphate dehydrogenase subunit B (AnaerobicglpB G-3-P Z3500 dehydrogenase ECs3127 subunit B) (Anaerobic419 Glycerophospholipid G3Pdhase B) (EC metabolism 1.1.5.3) 753 Q8XE26 Q8XE26_ECO57 Ribonucleoside-diphosphate reductase (EC 1.17.4.1) nrdA ECs3117 Z3489 761 Purine metabolism Pyrimidine metabolism 754 Q8XE27 SYT_ECO57 Threonine--tRNA ligase (EC 6.1.1.3) (Threonyl-tRNA synthetase)thrS (ThrRS) Z2748 ECs2426 642 Aminoacyl-tRNA biosynthesis 755 Q8XE29 UBIG_ECO57 3-demethylubiquinone-9 3-methyltransferase (EC 2.1.1.64) (2-polyprenyl-6-hydroxyphenylubiG Z3486 ECs3115 methylase) (EC240 2.1.1.222)Ubiquinone (3,4-dihydroxy-5-hexaprenylbenzoate and other terpenoid-quinone biosynthesis methyltransferase) (DHHB methyltransferase) 756 Q8XE32 SYFB_ECO57 Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNApheT Z2742 synthetase ECs2420 beta subunit) (PheRS)795 Aminoacyl-tRNA biosynthesis 757 Q8XE41 OMPC_ECO57 Outer membrane protein C (Outer membrane protein 1B) (Porin OmpC)ompC Z3473 ECs3104 367 Two-component system* 758 Q8XE48 Q8XE48_ECO57 Ferredoxin-type protein (Ferredoxin-type protein: electron transfer)napG ECs3094 Z3462 231 Nitrogen metabolism* 759 Q8XE56 Q8XE56_ECO57 Ferredoxin-type protein (Ferredoxin-type protein: electron transfer)napH ECs3093 Z3461 287 Nitrogen metabolism* 760 Q8XE58 CCMA_ECO57 Cytochrome c biogenesis ATP-binding export protein CcmA (EC 3.6.3.41)ccmA Z3458 (Heme ECs3090 exporter protein A) 207 ABC transporters 761 Q8XE66 Q8XE66_ECO57 Nitrate/nitrite response regulator (Sensor NarQ) (Nitrate/nitrite responsenarP ECs3082 regulator Z3450 NarP) 215 Two-component system* 762 Q8XE69 RL25_ECO57 50S ribosomal protein L25 rplY Z3444 ECs3077 94 Ribosome 763 Q8XE75 Q8XE75_ECO57 Geranyltranstransferase (Geranyltranstransferase (FarnesyldiphosphateispA ECs0475 synthase)) Z0524 299 Terpenoid backbone biosynthesis 764 Q8XE76 DXS_ECO57 1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) (1-deoxyxylulose-5-phosphatedxs Z0523 ECs0474 synthase) (DXP synthase)620 Terpenoid (DXPS) backbone biosynthesis 765 Q8XE86 Q8XE86_ECO57 Phosphatidylglycerophosphatase pgpA ECs0471 Z0520 171 Glycerophospholipid metabolism 766 Q8XE87 THIL_ECO57 Thiamine-monophosphate kinase (TMP kinase) (Thiamine-phosphatethiL kinase)Z0519 ECs0470(EC 2.7.4.16) 325 Thiamine metabolism 767 Q8XE88 Q8XE88_ECO57 Bifunctional pyrimidine deaminase/reductase in pathway of riboflavinribD synthesisECs0467 Z0515 367 Riboflavin metabolism 768 Q8XE91 Q8XE91_ECO57 Fructose-specific PTS transport system protein (PTS system, fructose-specificfruA ECs3059 transport Z3425 protein) 563 Fructose and mannose metabolism Phosphotransferase system* 769 Q8XE99 Q8XE99_ECO57 Positive and negative sensor protein for pho regulon (Positive andphoR negative ECs0450 sensor Z0498 protein for pho regulon431 PhoR)Two-component system* 770 Q8XEA0 Q8XEA0_ECO57 Putative NAGC-like transcriptional regulator (Putative uncharacterizedyajF ECs0444 protein yajF) Z0493 348 Fructose and mannose metabolism Starch and sucrose metabolism Amino sugar and nucleotide sugar metabolism 771 Q8XEA7 SERC_ECO57 Phosphoserine aminotransferase (EC 2.6.1.52) (PhosphohydroxythreonineserC Z1253 aminotransferase) ECs0990 (PSAT) 362 Glycine, serine and threonine metabolism Vitamin B6 metabolism Methane metabolism* 772 Q8XEB1 Q8XEB1_ECO57 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) proC ECs0437 Z0482 269 Arginine and proline metabolism 773 Q8XEB4 Q8XEB4_ECO57 Formate acetyltransferase 1 pflB ECs0986 Z1248 760 Pyruvate metabolism Propanoate metabolism Butanoate metabolism 774 Q8XED0 MACB_ECO57 Macrolide export ATP-binding/permease protein MacB (EC 3.6.3.-)macB Z1116 ECs0965 648 ABC transporters 775 Q8XEG2 GLMS_ECO57 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]glmS (EC Z5227 2.6.1.16) ECs4671 (D-fructose-6-phosphate609 amidotransferase)Alanine, aspartate (GFAT) and glutamate (Glucosamine-6-phosphate metabolism synthase) (Hexosephosphate aminotransferase) (L-glutamine-D-fructose-6-phosphate amidotransferase) Amino sugar and nucleotide sugar metabolism 776 Q9S5G3 HIS2_ECO57 Histidine biosynthesis bifunctional protein HisIE [Includes: Phosphoribosyl-AMPhisI hisIE Z3188 cyclohydrolase ECs2827 (PRA-CH)203 (ECHistidine 3.5.4.19); metabolism Phosphoribosyl-ATP pyrophosphatase (PRA-PH) (EC 3.6.1.31)] 777 Q9S5G4 HIS4_ECO57 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]hisA imidazole-4-carboxamideZ3186 ECs2825 isomerase245 (ECHistidine 5.3.1.16) metabolism (Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase) 778 Q9S5G5 HIS7_ECO57 Histidine biosynthesis bifunctional protein HisB [Includes: Histidinol-phosphatasehisB Z3184 ECs2823 (EC 3.1.3.15); Imidazoleglycerol-phosphate355 Histidine metabolism dehydratase (IGPD) (EC 4.2.1.19)] 779 Q9S5G6 HIS8_ECO57 Histidinol-phosphate aminotransferase (EC 2.6.1.9) (Imidazole acetol-phosphatehisC Z3183 ECs2822 transaminase) 356 Histidine metabolism Tyrosine metabolism Phenylalanine metabolism Phenylalanine, tyrosine and tryptophan biosynthesis Novobiocin biosynthesis* 780 Q9S6P8 MUTS_ECO57 DNA mismatch repair protein MutS mutS fdv Z4043 ECs3589 853 Mismatch repair

* represents targets from unique pathways List of 350 non-host essential proteins from common and unique pathways.

No Uniprot ID Entry name Protein names Gene names Length Associated metabolic pathways Organism 1 O82884 O82884_ECO57 Type II secretion pathway related protein (Type II secretion protein) etpE ECO57PM03 L7034 501 Bacterial secretion system* Escherichia coli O157:H7 2 P0A3L9 KITH_ECO57 Thymidine kinase (EC 2.7.1.21) tdk Z2015 ECs1740 205 Pyrimidine metabolism Escherichia coli O157:H7 3 P0A4D1 RS6_ECO57 30S ribosomal protein S6 rpsF Z5809 ECs5176 131 Ribosome Escherichia coli O157:H7 4 P0A6A5 ACKA_ECO57 Acetate kinase (EC 2.7.2.1) (Acetokinase) ackA ack Z3558 ECs3180 400 Taurine and hypotaurine metabolism Escherichia coli O157:H7 Pyruvate metabolism Propanoate metabolism Methane metabolism* 5 P0A6I2 KCY_ECO57 Cytidylate kinase (CK) (EC 2.7.4.25) (Cytidine monophosphate kinase) (CMP kinase) cmk mssA Z1256 ECs0993 227 Pyrimidine metabolism Escherichia coli O157:H7 6 P0A6I7 COAD_ECO57 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) (Dephospho-CoA pyrophosphorylase) (Pantetheine-phosphatecoaD kdtB Z5058 ECs4509 adenylyltransferase) (PPAT) 159 Pantothenate and CoA biosynthesis Escherichia coli O157:H7 7 P0A6K2 DAPF_ECO57 Diaminopimelate epimerase (DAP epimerase) (EC 5.1.1.7) dapF Z5326 ECs4739 274 Lysine biosynthesis Escherichia coli O157:H7 8 P0A6K8 DEOB_ECO57 Phosphopentomutase (EC 5.4.2.7) (Phosphodeoxyribomutase) deoB drm thyR Z5985 ECs5342 407 Pentose phosphate pathway Escherichia coli O157:H7 Purine metabolism 9 P0A6Q4 FABA_ECO57 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.60) (Beta-hydroxydecanoyl thioesterfabA Z1304 dehydrase) ECs1038 172 Fatty acid biosynthesis Escherichia coli O157:H7 10 P0A6Q8 FABZ_ECO57 (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase ((3R)-hydroxymyristoyl ACP dehydrase)fabZ Z0192 (EC 4.2.1.-) ECs0182 151 Fatty acid biosynthesis Escherichia coli O157:H7 11 P0A6R2 FABH_ECO57 3-oxoacyl-[acyl-carrier-protein] synthase 3 (EC 2.3.1.180) (3-oxoacyl-[acyl-carrier-protein] synthasefabH Z1730 III) (Beta-ketoacyl-ACP ECs1469 synthase III) (KAS III) (EcFabH) 317 Fatty acid biosynthesis Escherichia coli O157:H7 12 P0A6X2 HEM1_ECO57 Glutamyl-tRNA reductase (GluTR) (EC 1.2.1.70) hemA Z1981 ECs1715 418 Porphyrin and chlorophyll metabolism Escherichia coli O157:H7 13 P0A6X5 HFQ_ECO57 Protein hfq (HF-1) (Host factor-I protein) (HF-I) hfq Z5779 ECs5148 102 RNA degradation Escherichia coli O157:H7 14 P0A727 LPXC_ECO57 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (EC 3.5.1.-) (UDP-3-O-acyl-GlcNAclpxC Z0106 deacetylase) ECs0100 305 Lipopolysaccharide biosynthesis* Escherichia coli O157:H7 15 P0A732 MGSA_ECO57 Methylglyoxal synthase (MGS) (EC 4.2.3.3) mgsA Z1314 ECs1047 152 Pyruvate metabolism Escherichia coli O157:H7 16 P0A740 MOAC_ECO57 Molybdenum cofactor biosynthesis protein C moaC chlA3 Z1002 ECs0861 161 Folate biosynthesis Escherichia coli O157:H7 Sulfur relay system 17 P0A778 RPPH_ECO57 RNA pyrophosphohydrolase (EC 3.6.1.-) ((Di)nucleoside polyphosphate hydrolase) rppH nudH Z4147 ECs3687 176 RNA degradation Escherichia coli O157:H7 18 P0A795 PDXJ_ECO57 Pyridoxine 5'-phosphate synthase (PNP synthase) (EC 2.6.99.2) pdxJ Z3845 ECs3430 243 Vitamin B6 metabolism Escherichia coli O157:H7 19 P0A7B0 IPYR_ECO57 Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) ppa Z5837 ECs5204 176 Oxidative phosphorylation Escherichia coli O157:H7 20 P0A7F1 PYRH_ECO57 Uridylate kinase (UK) (EC 2.7.4.22) (Uridine monophosphate kinase) (UMP kinase) (UMPK)pyrH Z0182 ECs0173 241 Pyrimidine metabolism Escherichia coli O157:H7 21 P0A7F5 PYRI_ECO57 Aspartate carbamoyltransferase regulatory chain pyrI Z5855 ECs5221 153 Pyrimidine metabolism Escherichia coli O157:H7 Alanine, aspartate and glutamate metabolism 22 P0A7H2 RECF_ECO57 DNA replication and repair protein RecF recF uvrF Z5191 ECs4635 357 Homologous recombination Escherichia coli O157:H7 23 P0A7I8 RIBA_ECO57 GTP cyclohydrolase-2 (EC 3.5.4.25) (GTP cyclohydrolase II) ribA Z2531 ECs1850 196 Riboflavin metabolism Escherichia coli O157:H7 24 P0A7J1 RIBB_ECO57 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) (EC 4.1.99.12) ribB htrP Z4399 ECs3929 217 Riboflavin metabolism Escherichia coli O157:H7 25 P0A7J5 RL10_ECO57 50S ribosomal protein L10 rplJ Z5558 ECs4908 165 Ribosome Escherichia coli O157:H7 26 P0A7L2 RL1_ECO57 50S ribosomal protein L1 rplA Z5557 ECs4907 234 Ribosome Escherichia coli O157:H7 27 P0A7M4 RL28_ECO57 50S ribosomal protein L28 rpmB Z5061 ECs4512 78 Ribosome Escherichia coli O157:H7 28 P0A7M8 RL29_ECO57 50S ribosomal protein L29 rpmC Z4683 ECs4177 63 Ribosome Escherichia coli O157:H7 29 P0A7N0 RL31_ECO57 50S ribosomal protein L31 rpmE Z5484 ECs4863 70 Ribosome Escherichia coli O157:H7 30 P0A7Q2 RL35_ECO57 50S ribosomal protein L35 rpmI Z2746 ECs2424 65 Ribosome Escherichia coli O157:H7 31 P0A7U9 RS20_ECO57 30S ribosomal protein S20 rpsT Z0027 ECs0026 87 Ribosome Escherichia coli O157:H7 32 P0A7W0 RS4_ECO57 30S ribosomal protein S4 rpsD ramA Z4666 ECs4161 206 Ribosome Escherichia coli O157:H7 33 P0A7Z6 RPOA_ECO57 DNA-directed RNA polymerase subunit alpha (RNAP subunit alpha) (EC 2.7.7.6) (RNA polymeraserpoA Z4665 subunit ECs4160 alpha) (Transcriptase subunit alpha) 329 Purine metabolism Escherichia coli O157:H7 Pyrimidine metabolism 34 P0A802 RPOZ_ECO57 DNA-directed RNA polymerase subunit omega (RNAP omega subunit) (EC 2.7.7.6) (RNA polymeraserpoZ Z5075 omega ECs4524 subunit) (Transcriptase subunit omega) 91 Purine metabolism Escherichia coli O157:H7 Pyrimidine metabolism RNA polymerase 35 P0A811 RUVA_ECO57 Holliday junction ATP-dependent DNA helicase RuvA (EC 3.6.4.12) ruvA Z2913 ECs2571 203 Homologous recombination Escherichia coli O157:H7 36 P0A816 RUVC_ECO57 Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4) (Holliday junction nuclease RuvC)ruvC Z2915 (Holliday ECs2573 junction resolvase RuvC) 173 Homologous recombination Escherichia coli O157:H7 37 P0A892 TUSA_ECO57 Sulfurtransferase TusA (EC 2.8.1.-) (tRNA 2-thiouridine synthesizing protein A) tusA Z4844 ECs4319 81 Sulfur relay system Escherichia coli O157:H7 38 P0A8Q4 FRDD_ECO57 Fumarate reductase subunit D (Fumarate reductase 13 kDa hydrophobic protein) frdD Z5758 ECs5132 119 Citrate cycle (TCA cycle) Escherichia coli O157:H7 Oxidative phosphorylation Butanoate metabolism Toluene degradation* Two-component system* 39 P0A966 CHEW_ECO57 Chemotaxis protein CheW cheW Z2941 ECs2597 167 Two-component system* Escherichia coli O157:H7 Bacterial chemotaxis* 40 P0A990 DPO3B_ECO57 DNA polymerase III subunit beta (EC 2.7.7.7) dnaN Z5192 ECs4636 366 Purine metabolism Escherichia coli O157:H7 Pyrimidine metabolism DNA replication Mismatch repair Homologous recombination 41 P0A9D6 CYSE_ECO57 Serine acetyltransferase (SAT) (EC 2.3.1.30) cysE Z5034 ECs4485 273 Cysteine and methionine metabolism Escherichia coli O157:H7 Sulfur metabolism 42 P0A9J9 PHEA_ECO57 P-protein [Includes: Chorismate mutase (CM) (EC 5.4.99.5); Prephenate dehydratase (PDT) (ECpheA 4.2.1.51)] Z3891 ECs3462 386 Phenylalanine, tyrosine and tryptophan biosynthesis Escherichia coli O157:H7 43 P0A9M6 XGPT_ECO57 Xanthine phosphoribosyltransferase (EC 2.4.2.22) (Xanthine-guanine phosphoribosyltransferase)gpt Z0299(XGPRT) ECs0265 152 Purine metabolism Escherichia coli O157:H7 44 P0A9Q3 ARCA_ECO57 Aerobic respiration control protein ArcA arcA Z6004 ECs5359 238 Two-component system* Escherichia coli O157:H7 45 P0A9R0 DHAS_ECO57 Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (ASADH) (EC 1.2.1.11) (Aspartate-beta-semialdehydeasd Z4797 ECs4278 dehydrogenase) 367 Glycine, serine and threonine metabolism Escherichia coli O157:H7 Cysteine and methionine metabolism Lysine biosynthesis 46 P0A9Z3 GLNB_ECO57 Nitrogen regulatory protein P-II 1 glnB Z3829 ECs3419 112 Two-component system* Escherichia coli O157:H7 47 P0AA06 PTHP_ECO57 Phosphocarrier protein HPr (EC 2.7.11.-) (Histidine-containing protein) ptsH Z3681 ECs3287 85 Phosphotransferase system* Escherichia coli O157:H7 48 P0AA18 OMPR_ECO57 Transcriptional regulatory protein OmpR ompR Z4760 ECs4247 239 Two-component system* Escherichia coli O157:H7 49 P0AAB0 ZRAP_ECO57 Zinc resistance-associated protein zraP Z5578 ECs4925 141 Two-component system* Escherichia coli O157:H7 50 P0AAK8 NRFC_ECO57 Protein nrfC nrfC Z5671 ECs5054 223 Nitrogen metabolism* Escherichia coli O157:H7 51 P0AB72 ALF_ECO57 Fructose-bisphosphate aldolase class 2 (FBP aldolase) (FBPA) (EC 4.1.2.13) (Fructose-1,6-bisphosphatefbaA Z4263 aldolase) ECs3796 (Fructose-bisphosphate aldolase class II) 359 Glycolysis / Gluconeogenesis Escherichia coli O157:H7 Pentose phosphate pathway Fructose and mannose metabolism Methane metabolism* 52 P0AB76 KBAY_ECO57 D-tagatose-1,6-bisphosphate aldolase subunit KbaY (TBPA) (TagBP aldolase) (EC 4.1.2.40) (D-tagatose-bisphosphatekbaY agaY Z4491 ECs4017 aldolase class II) (Ketose 1,6-bisphosphate aldolase286 classGalactose II) (Tagatose-bisphosphate metabolism aldolase) Escherichia coli O157:H7 53 P0AB92 AROG_ECO57 Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive (EC 2.5.1.54) (3-deoxy-D-arabino-heptulosonatearoG Z0924 ECs0782 7-phosphate synthase) (DAHP synthase) (Phospho-2-keto-3-deoxyheptonate350 Phenylalanine, tyrosinealdolase) and tryptophan biosynthesis Escherichia coli O157:H7 54 P0ABJ7 CYOD_ECO57 Cytochrome o ubiquinol oxidase protein CyoD (Ubiquinol oxidase chain D) cyoD Z0532 ECs0483 109 Oxidative phosphorylation Escherichia coli O157:H7 55 P0ABK4 CYDB_ECO57 Cytochrome d ubiquinol oxidase subunit 2 (EC 1.10.3.-) (Cytochrome bd-I oxidase subunit II)cydB (Cytochrome Z0901 ECs0769 d ubiquinol oxidase subunit II) 379 Oxidative phosphorylation Escherichia coli O157:H7 Two-component system* 56 P0ABL0 NRFA_ECO57 Cytochrome c-552 (EC 1.7.2.2) (Ammonia-forming cytochrome c nitrite reductase) (CytochromenrfA c Z5669 nitrite ECs5052reductase) 478 Nitrogen metabolism* Escherichia coli O157:H7 57 P0ABM3 CCMC_ECO57 Heme exporter protein C (Cytochrome c-type biogenesis protein CcmC) ccmC Z3456 ECs3088 245 ABC transporters Escherichia coli O157:H7 58 P0ABN3 KDGL_ECO57 Diacylglycerol kinase (DAGK) (EC 2.7.1.107) (Diglyceride kinase) (DGK) dgkA Z5641 ECs5025 122 Glycerolipid metabolism Escherichia coli O157:H7 Glycerophospholipid metabolism 59 P0ABP9 DEOD_ECO57 Purine nucleoside phosphorylase DeoD-type (PNP) (EC 2.4.2.1) deoD Z5986 ECs5343 239 Purine metabolism Escherichia coli O157:H7 Pyrimidine metabolism Nicotinate and nicotinamide metabolism 60 P0ABS6 PRIM_ECO57 DNA primase (EC 2.7.7.-) dnaG Z4419 ECs3949 581 DNA replication Escherichia coli O157:H7 61 P0AC77 KDTA_ECO57 3-deoxy-D-manno-octulosonic-acid transferase (EC 2.4.-.-) (KDO transferase) waaA kdtA Z5057 ECs4508 425 Lipopolysaccharide biosynthesis* Escherichia coli O157:H7 62 P0ACB6 HEMG_ECO57 Protoporphyrinogen IX dehydrogenase [menaquinone] (EC 1.3.5.3) hemG Z5372 ECs4778 181 Porphyrin and chlorophyll metabolism Escherichia coli O157:H7 63 P0ACV1 HTRB_ECO57 Lipid A biosynthesis lauroyl acyltransferase (EC 2.3.1.-) (Heat shock protein B) htrB waaM Z1690 ECs1432 306 Lipopolysaccharide biosynthesis* Escherichia coli O157:H7 64 P0AD00 CUSR_ECO57 Transcriptional regulatory protein CusR cusR Z0709 ECs0609 227 Two-component system* Escherichia coli O157:H7 65 P0AD67 PBP2_ECO57 Penicillin-binding protein 2 (PBP-2) mrdA pbpA Z0781 ECs0673 633 Peptidoglycan biosynthesis* Escherichia coli O157:H7 66 P0AD69 FTSI_ECO57 Peptidoglycan synthase FtsI (EC 2.4.1.129) (Penicillin-binding protein 3) (PBP-3) (PeptidoglycanftsI pbpB glycosyltransferase Z0094 ECs0088 3) 588 Peptidoglycan biosynthesis* Escherichia coli O157:H7 67 P0ADC5 LOLC_ECO57 Lipoprotein-releasing system transmembrane protein LolC lolC Z1757 ECs1494 399 ABC transporters Escherichia coli O157:H7 68 P0ADZ9 YAJC_ECO57 UPF0092 membrane protein YajC yajC Z0506 ECs0458 110 Protein export Escherichia coli O157:H7 Bacterial secretion system* 69 P0AE38 ASTA_ECO57 Arginine N-succinyltransferase (AST) (EC 2.3.1.109) (AOST) astA Z2779 ECs2453 344 Arginine and proline metabolism Escherichia coli O157:H7 70 P0AE68 CHEY_ECO57 Chemotaxis protein CheY cheY Z2936 ECs2592 129 Two-component system* Escherichia coli O157:H7 Bacterial chemotaxis* 71 P0AE75 CITT_ECO57 Citrate carrier (Citrate transporter) (Citrate/succinate antiporter) citT Z0756 ECs0651 487 Two-component system* Escherichia coli O157:H7 72 P0AEA9 CYSG_ECO57 Siroheme synthase [Includes: Uroporphyrinogen-III C-methyltransferase (Urogen III methylase)cysG (EC Z4729 2.1.1.107) ECs4219 (SUMT) (Uroporphyrinogen III methylase) (UROM); Precorrin-2457 Porphyrin dehydrogenase and chlorophyll (EC 1.3.1.76); metabolism Sirohydrochlorin ferrochelataseEscherichia (EC coli4.99.1.4)] O157:H7 73 P0AEE9 DMA_ECO57 DNA adenine methylase (EC 2.1.1.72) (DNA adenine methyltransferase) (Deoxyadenosyl-methyltransferase)dam Z4740 ECs4229 278 Mismatch repair Escherichia coli O157:H7 74 P0AEG3 DPPC_ECO57 Dipeptide transport system permease protein dppC dppC Z4959 ECs4422 300 ABC transporters Escherichia coli O157:H7 75 P0AEQ8 GLNP_ECO57 Glutamine transport system permease protein glnP glnP Z1032 ECs0888 219 ABC transporters Escherichia coli O157:H7 76 P0AEU5 HISM_ECO57 Histidine transport system permease protein hisM hisM Z3569 ECs3191 238 ABC transporters Escherichia coli O157:H7 77 P0AEY4 MAZG_ECO57 Nucleoside triphosphate pyrophosphohydrolase (NTP-PPase) (EC 3.6.1.8) mazG Z4096 ECs3641 263 Purine metabolism Escherichia coli O157:H7 Pyrimidine metabolism 78 P0AF02 MODB_ECO57 Molybdenum transport system permease protein modB modB Z0934 ECs0792 229 ABC transporters Escherichia coli O157:H7 79 P0AF14 MTNN_ECO57 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTA/SAH nucleosidase) (MTAN)mtnN (ECZ0170 3.2.2.9) ECs0163 (5'-methylthioadenosine nucleosidase) (MTA nucleosidase)232 (S-adenosylhomocysteineCysteine and methionine nucleosidase)metabolism (AdoHcy nucleosidase)Escherichia (SAH nucleosidase) coli O157:H7 (SRH nucleosidase) 80 P0AF17 MURJ_ECO57 Protein MurJ homolog murJ mviN Z1707 ECs1447 511 Peptidoglycan biosynthesis* Escherichia coli O157:H7 81 P0AF30 NARL_ECO57 Nitrate/nitrite response regulator protein NarL narL Z1996 ECs1726 216 Two-component system* Escherichia coli O157:H7 82 P0AFA0 LPTF_ECO57 Lipopolysaccharide export system permease protein lptF lptF Z5873 ECs5238 366 ABC transporters Escherichia coli O157:H7 83 P0AFB0 NIKC_ECO57 Nickel transport system permease protein nikC nikC Z4870 ECs4345 277 ABC transporters Escherichia coli O157:H7 84 P0AFB9 NTRC_ECO57 Nitrogen regulation protein NR(I) glnG Z5404 ECs4790 469 Two-component system* Escherichia coli O157:H7 85 P0AFH7 OPPC_ECO57 Oligopeptide transport system permease protein oppC oppC Z2021 ECs1745 302 ABC transporters Escherichia coli O157:H7 86 P0AFJ3 PHNA_ECO57 Protein phnA phnA Z5710 ECs5090 111 Phosphonate and phosphinate metabolism* Escherichia coli O157:H7 87 P0AFJ6 PHOB_ECO57 Phosphate regulon transcriptional regulatory protein phoB phoB Z0497 ECs0449 229 Two-component system* Escherichia coli O157:H7 88 P0AFK8 POTC_ECO57 Spermidine/putrescine transport system permease protein PotC potC Z1763 ECs1500 264 ABC transporters Escherichia coli O157:H7 89 P0AFL8 PPX_ECO57 Exopolyphosphatase (ExopolyPase) (EC 3.6.1.11) (Metaphosphatase) ppx Z3765 ECs3364 513 Purine metabolism Escherichia coli O157:H7 90 P0AFU5 QSEF_ECO57 Transcriptional regulatory protein QseF (Quorum-sensing regulator protein F) qseF yfhA Z3830 ECs3420 444 Two-component system* Escherichia coli O157:H7 91 P0AG04 UBIX_ECO57 3-octaprenyl-4-hydroxybenzoate carboxy-lyase (EC 4.1.1.-) (Polyprenyl p-hydroxybenzoate decarboxylase)ubiX Z3573 ECs3195 189 Ubiquinone and other terpenoid-quinone biosynthesis Escherichia coli O157:H7 92 P0AG22 RELA_ECO57 GTP pyrophosphokinase (EC 2.7.6.5) ((p)ppGpp synthase) (ATP:GTP 3'-pyrophosphotransferase)relA Z4099(ppGpp ECs3644 synthase I) 744 Purine metabolism Escherichia coli O157:H7 93 P0AG42 RIBF_ECO57 Riboflavin biosynthesis protein RibF [Includes: Riboflavin kinase (EC 2.7.1.26) (Flavokinase);ribF FMN Z0029 adenylyltransferase ECs0028 (EC 2.7.7.2) (FAD pyrophosphorylase) (FAD synthase)]313 Riboflavin metabolism Escherichia coli O157:H7 94 P0AG53 RL30_ECO57 50S ribosomal protein L30 rpmD Z4672 ECs4167 59 Ribosome Escherichia coli O157:H7 95 P0AG57 RL6_ECO57 50S ribosomal protein L6 rplF Z4675 ECs4170 177 Ribosome Escherichia coli O157:H7 96 P0AG88 SECB_ECO57 Protein-export protein SecB secB Z5036 ECs4487 155 Protein export Escherichia coli O157:H7 Bacterial secretion system* 97 P0AG91 SECD_ECO57 Protein translocase subunit SecD secD Z0507 ECs0459 615 Protein export Escherichia coli O157:H7 Bacterial secretion system* 98 P0AG95 SECF_ECO57 Protein translocase subunit SecF secF Z0508 ECs0460 323 Protein export Escherichia coli O157:H7 Bacterial secretion system* 99 P0AG98 SECE_ECO57 Preprotein translocase subunit SecE secE Z5554 ECs4904 127 Protein export Escherichia coli O157:H7 Bacterial secretion system* 100 P0AGA1 SECG_ECO57 Protein-export membrane protein SecG (P12) (Preprotein translocase band 1 subunit) secG Z4537 ECs4054 110 Protein export Escherichia coli O157:H7 Bacterial secretion system* 101 P58194 UBID_ECO57 3-octaprenyl-4-hydroxybenzoate carboxy-lyase (EC 4.1.1.-) (Polyprenyl p-hydroxybenzoate decarboxylase)ubiD Z5364 ECs4771 497 Ubiquinone and other terpenoid-quinone biosynthesis Escherichia coli O157:H7 102 P58209 DAPB_ECO57 Dihydrodipicolinate reductase (DHPR) (EC 1.3.1.26) dapB Z0036 ECs0034 273 Lysine biosynthesis Escherichia coli O157:H7 103 P58237 HIS5_ECO57 Imidazole glycerol phosphate synthase subunit HisH (EC 2.4.2.-) (IGP synthase glutamine amidotransferasehisH Z3185 ECs2824 subunit) (IGP synthase subunit HisH) (ImGP synthase subunit196 HisH)Histidine (IGPS metabolism subunit HisH) Escherichia coli O157:H7 104 P58256 ILVC_ECO57 Ketol-acid reductoisomerase (EC 1.1.1.86) (Acetohydroxy-acid isomeroreductase) (Alpha-keto-beta-hydroxylacililvC Z5285 ECs4708 reductoisomerase) 491 Valine, leucine and isoleucine biosynthesis Escherichia coli O157:H7 Pantothenate and CoA biosynthesis 105 P58263 THIG_ECO57 Thiazole synthase (EC 2.8.1.10) thiG Z5565 ECs4914 256 Thiamine metabolism Escherichia coli O157:H7 106 P58357 TORR_ECO57 TorCAD operon transcriptional regulatory protein torR torR Z1412 ECs1150 230 Two-component system* Escherichia coli O157:H7 107 P58364 TORD_ECO57 Chaperone protein TorD torD Z1416 ECs1153 199 Two-component system* Escherichia coli O157:H7 108 P58640 PYRF_ECO57 Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) (OMP decarboxylase) (OMPDCase) (OMPdecase)pyrF Z2525 ECs1854 245 Pyrimidine metabolism Escherichia coli O157:H7 109 P58704 CYNS_ECO57 Cyanate hydratase (Cyanase) (EC 4.2.1.104) (Cyanate hydrolase) (Cyanate lyase) cynS cnt Z0436 ECs0393 156 Nitrogen metabolism* Escherichia coli O157:H7 110 P58713 PDXA_ECO57 4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262) (4-(phosphohydroxy)-L-threoninepdxA dehydrogenase)Z0061 ECs0057 329 Vitamin B6 metabolism Escherichia coli O157:H7 111 P60625 RL24_ECO57 50S ribosomal protein L24 rplX Z4679 ECs4174 104 Ribosome Escherichia coli O157:H7 112 P60665 HIS6_ECO57 Imidazole glycerol phosphate synthase subunit HisF (EC 4.1.3.-) (IGP synthase cyclase subunit)hisF (IGP Z3187 synthase ECs2826 subunit HisF) (ImGP synthase subunit HisF) (IGPS subunit258 HisF)Histidine metabolism Escherichia coli O157:H7 113 P60784 PLSY_ECO57 Glycerol-3-phosphate acyltransferase (G3P acyltransferase) (GPAT) (EC 2.3.1.15) (EC 2.3.1.n5)plsY (Lysophosphatidic ygiH Z4412 ECs3942 acid synthase) (LPA synthase) 205 Glycerolipid metabolism Escherichia coli O157:H7 Glycerophospholipid metabolism 114 P60933 UPPP_ECO57 Undecaprenyl-diphosphatase (EC 3.6.1.27) (Bacitracin resistance protein) (Undecaprenyl pyrophosphateuppP bacA upkphosphatase) Z4410 ECs3940 273 Peptidoglycan biosynthesis* Escherichia coli O157:H7 115 P61717 RISB_ECO57 6,7-dimethyl-8-ribityllumazine synthase (DMRL synthase) (Lumazine synthase) (EC 2.5.1.9) ribH(Riboflavin ribE Z0516 synthase ECs0468 beta chain) 156 Riboflavin metabolism Escherichia coli O157:H7 116 P61951 FLAV_ECO57 Flavodoxin-1 fldA Z0832 ECs0715 176 Nitrogen metabolism* Escherichia coli O157:H7 117 P62397 SECM_ECO57 Secretion monitor secM Z0107 ECs0101 170 Protein export Escherichia coli O157:H7 Bacterial secretion system* 118 P62616 ISPE_ECO57 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (CMK) (EC 2.7.1.148) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritolispE Z1979 ECs1713 kinase) 283 Terpenoid backbone biosynthesis Escherichia coli O157:H7 119 P62618 ISPF_ECO57 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECDP-synthase) (MECPS) (EC 4.6.1.12)ispF Z4054 ECs3600 159 Terpenoid backbone biosynthesis Escherichia coli O157:H7 120 P62622 ISPG_ECO57 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (EC 1.17.7.1) (1-hydroxy-2-methyl-2-(E)-butenylispG gcpE Z3778 4-diphosphate ECs3377 synthase) 372 Terpenoid backbone biosynthesis Escherichia coli O157:H7 121 P62625 ISPH_ECO57 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC 1.17.1.2) ispH lytB Z0034 ECs0032 316 Terpenoid backbone biosynthesis Escherichia coli O157:H7 122 P63225 GMHA_ECO57 Phosphoheptose isomerase (EC 5.3.1.28) (Sedoheptulose 7-phosphate isomerase) gmhA lpcA Z0280 ECs0249 192 Lipopolysaccharide biosynthesis* Escherichia coli O157:H7 123 P63486 ALLA_ECO57 Ureidoglycolate hydrolase (EC 3.5.3.19) allA Z0659 ECs0566 160 Purine metabolism Escherichia coli O157:H7 124 P63610 AROC_ECO57 Chorismate synthase (EC 4.2.3.5) (5-enolpyruvylshikimate-3-phosphate phospholyase) aroC Z3592 ECs3213 361 Phenylalanine, tyrosine and tryptophan biosynthesis Escherichia coli O157:H7 125 P63624 ASNA_ECO57 Aspartate--ammonia ligase (EC 6.3.1.1) (Asparagine synthetase A) asnA Z5245 ECs4686 330 Alanine, aspartate and glutamate metabolism Escherichia coli O157:H7 Cyanoamino acid metabolism Nitrogen metabolism* 126 P63633 MURI_ECO57 Glutamate racemase (EC 5.1.1.3) murI Z5528 ECs4898 285 D-Glutamine and D-glutamate metabolism Escherichia coli O157:H7 127 P64558 YGFM_ECO57 Uncharacterized protein ygfM ygfM Z4219 ECs3753 259 Selenocompound metabolism Escherichia coli O157:H7 128 P65323 LPXD_ECO57 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase (UDP-3-O-(3-OHC14)-GlcN N-acyltransferase)lpxD Z0191 ECs0181 (EC 2.3.1.191) 341 Lipopolysaccharide biosynthesis* Escherichia coli O157:H7 129 P65471 MURC_ECO57 UDP-N-acetylmuramate--L-alanine ligase (EC 6.3.2.8) (UDP-N-acetylmuramoyl-L-alanine synthetase)murC Z0101 ECs0095 491 D-Glutamine and D-glutamate metabolism Escherichia coli O157:H7 Peptidoglycan biosynthesis* 130 P65737 PLSX_ECO57 Phosphate acyltransferase (EC 2.3.1.n2) (Acyl-ACP phosphotransacylase) (Acyl-[acyl-carrier-protein]--phosphateplsX Z1729 ECs1468 acyltransferase) (Phosphate-acyl-ACP acyltransferase)356 Glycerolipid metabolism Escherichia coli O157:H7 Glycerophospholipid metabolism 131 P67026 SYGA_ECO57 Glycine--tRNA ligase alpha subunit (EC 6.1.1.14) (Glycyl-tRNA synthetase alpha subunit) (GlyRS)glyQ Z4984 ECs4443 303 Aminoacyl-tRNA biosynthesis Escherichia coli O157:H7 132 P67031 SYGB_ECO57 Glycine--tRNA ligase beta subunit (EC 6.1.1.14) (Glycyl-tRNA synthetase beta subunit) (GlyRS)glyS Z4983 ECs4442 689 Aminoacyl-tRNA biosynthesis Escherichia coli O157:H7 133 P67676 PRIB_ECO57 Primosomal replication protein n priB Z5810 ECs5177 104 Homologous recombination Escherichia coli O157:H7 134 P68681 RS21_ECO57 30S ribosomal protein S21 rpsU Z4418 ECs3948 71 Ribosome Escherichia coli O157:H7 135 P69424 TATC_ECO57 Sec-independent protein translocase protein TatC tatC mttB Z5360 ECs4768 258 Bacterial secretion system* Escherichia coli O157:H7 136 P69772 PAD1_ECO57 Probable aromatic acid decarboxylase (EC 4.1.1.-) pad1 Z4047 ECs3593 197 Ubiquinone and other terpenoid-quinone biosynthesis Escherichia coli O157:H7 137 P69788 PTGCB_ECO57 PTS system glucose-specific EIICB component (EIICB-Glc) (EII-Glc) [Includes: Glucose permeaseptsG Z1740 IIC component ECs1479 (PTS system glucose-specific EIIC component); Glucose-specific477 Glycolysis phosphotransferase / Gluconeogenesis enzyme IIB component (EC 2.7.1.69)Escherichia (PTS colisystem O157:H7 glucose-specific EIIB component)] Amino sugar and nucleotide sugar metabolism Phosphotransferase system* 138 P69793 PTQA_ECO57 N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIA component (EC 2.7.1.-) (EIIA-Chb)chbA celC (EIII-Chb) Z2766 ECs2442 (PTS system N,N'-diacetylchitobiose-specific EIIA component)116 Phosphotransferase system* Escherichia coli O157:H7 139 P69799 PTNAB_ECO57 PTS system mannose-specific EIIAB component (EIIAB-Man) [Includes: Mannose-specific phosphotransferasemanX Z2860 ECs2527 enzyme IIA component (EC 2.7.1.-) (EIII-Man) (PTS system323 Fructose mannose-specific and mannose EIIA metabolism component); Mannose-specific phosphotransferaseEscherichia coli enzyme O157:H7 IIB component (EC 2.7.1.69) (PTS system mannose-specific EIIB component)] Amino sugar and nucleotide sugar metabolism Phosphotransferase system* 140 P69812 PTFAH_ECO57 Multiphosphoryl transfer protein (MTP) (Phosphotransferase FPr protein) (Pseudo-HPr) [Includes:fruB Z3427 Phosphocarrier ECs3061 protein HPr (Protein H); Fructose-specific phosphotransferase376 Fructose enzyme and IIA mannose component metabolism (EC 2.7.1.-) (PTS system fructose-specificEscherichia EIIA coli component)]O157:H7 Phosphotransferase system* 141 P69827 PTMCB_ECO57 PTS system mannitol-specific cryptic EIICB component (EIICB-Mtl) (EII-Mtl) [Includes: MannitolcmtA Z4277 permease ECs3808 IIC component (PTS system mannitol-specific EIIC component);462 Fructose Mannitol-specific and mannose phosphotransferase metabolism enzyme IIB componentEscherichia (EC 2.7.1.69) coli O157:H7 (PTS system mannitol-specific EIIB component)] Phosphotransferase system* 142 P69830 PTQB_ECO57 N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIB component (EC 2.7.1.69) (PTSchbB system celA N,N'-diacetylchitobiose-specificZ2768 ECs2444 EIIB component) 106 Phosphotransferase system* Escherichia coli O157:H7 143 P69915 CSRA_ECO57 Carbon storage regulator csrA zfiA Z3998 ECs3553 61 Two-component system* Escherichia coli O157:H7 144 Q7A909 Q7A909_ECO57 Putative aldolase ECs5069 286 Glycolysis / Gluconeogenesis Escherichia coli O157:H7 Pentose phosphate pathway Fructose and mannose metabolism Methane metabolism* 145 Q7A978 KATG1_ECO57 Catalase-peroxidase 1 (CP 1) (EC 1.11.1.21) (Peroxidase/catalase 1) katG1 Z5497 ECs4871 726 Phenylalanine metabolism Escherichia coli O157:H7 Tryptophan metabolism Methane metabolism* 146 Q7A9V4 Q7A9V4_ECO57 Mannitol-specific PTS system enzyme IIABC components ECs4475 637 Fructose and mannose metabolism Escherichia coli O157:H7 Phosphotransferase system* 147 Q7A9Z2 Q7A9Z2_ECO57 Dipeptide transport protein ECs4424 535 ABC transporters Escherichia coli O157:H7 Bacterial chemotaxis* 148 Q7AAG8 Q7AAG8_ECO57 Glutamate synthase large subunit ECs4091 1517 Alanine, aspartate and glutamate metabolism Escherichia coli O157:H7 Nitrogen metabolism* 149 Q7AAK7 Q7AAK7_ECO57 N-acetylgalactosamine-specific PTS system enzyme IIB component ECs4011 169 Galactose metabolism Escherichia coli O157:H7 Phosphotransferase system* 150 Q7AAL3 Q7AAL3_ECO57 Putative uncharacterized protein ECs4002 ECs4002 408 Glycine, serine and threonine metabolism Escherichia coli O157:H7 Glycerolipid metabolism Glyoxylate and dicarboxylate metabolism 151 Q7AAL9 Q7AAL9_ECO57 L-serine deaminase ECs3992 454 Glycine, serine and threonine metabolism Escherichia coli O157:H7 Cysteine and methionine metabolism 152 Q7ABT1 Q7ABT1_ECO57 Sulfate transport system permease W protein ECs3294 149 ABC transporters Escherichia coli O157:H7 153 Q7ABV7 Q7ABV7_ECO57 Multidrug resistance protein Y ECs3246 512 Two-component system* Escherichia coli O157:H7 154 Q7AC15 Q7AC15_ECO57 Isochorismate hydroxymutase 2 ECs3153 356 Ubiquinone and other terpenoid-quinone biosynthesis Escherichia coli O157:H7 Biosynthesis of siderophore group nonribosomal peptides* 155 Q7AC70 Q7AC70_ECO57 Putative transport system permease protein ECs3071 341 ABC transporters Escherichia coli O157:H7 156 Q7ACR3 Q7ACR3_ECO57 Exonuclease I ECs2813 475 Mismatch repair Escherichia coli O157:H7 157 Q7AD45 Q7AD45_ECO57 L-arabinose-binding periplasmic protein ECs2609 329 ABC transporters Escherichia coli O157:H7 158 Q7AD51 Q7AD51_ECO57 Methyl-accepting chemotaxis protein II ECs2596 553 Two-component system* Escherichia coli O157:H7 159 Q7AD93 Q7AD93_ECO57 L-serine deaminase ECs2523 454 Glycine, serine and threonine metabolism Escherichia coli O157:H7 Cysteine and methionine metabolism 160 Q7AD95 Q7AD95_ECO57 p-aminobenzoate synthetase component I ECs2521 453 Folate biosynthesis Escherichia coli O157:H7 161 Q7ADE7 ASTB_ECO57 N-succinylarginine dihydrolase (EC 3.5.3.23) astB Z2777 ECs2451 447 Arginine and proline metabolism Escherichia coli O157:H7 162 Q7ADM2 Q7ADM2_ECO57 Sensor histidine protein kinase RstA regulator ECs2315 433 Two-component system* Escherichia coli O157:H7 163 Q7ADN3 Q7ADN3_ECO57 Putative oxidoreductase major subunit ECs2294 808 Selenocompound metabolism Escherichia coli O157:H7 164 Q7AF85 Q7AF85_ECO57 4-amino-4-deoxychorismate lyase ECs1474 269 Folate biosynthesis Escherichia coli O157:H7 165 Q7AG83 Q7AG83_ECO57 Arginine 3rd transport system periplasmic binding protein ECs0943 243 ABC transporters Escherichia coli O157:H7 166 Q7AGM8 Q7AGM8_ECO57 PTS system, N-acetylglucosamine-specific enzyme IIABC ECs0709 648 Amino sugar and nucleotide sugar metabolism Escherichia coli O157:H7 167 Q7AGQ1 Q7AGQ1_ECO57 Citrate lyase alpha chain ECs0654 510 Citrate cycle (TCA cycle) Escherichia coli O157:H7 Two-component system* 168 Q7AGR4 Q7AGR4_ECO57 Ferric enterobactin (Enterochelin) binding protein periplasmic component ECs0631 318 ABC transporters Escherichia coli O157:H7 169 Q7AGY5 Q7AGY5_ECO57 Primosomal replication protein N'' ECs0520 175 Homologous recombination Escherichia coli O157:H7 170 Q7DB96 Q7DB96_ECO57 Lipid A-core:surface polymer ligase (Putative LPS biosynthesis enzyme) waaL ECs4500 Z5049 402 Lipopolysaccharide biosynthesis* Escherichia coli O157:H7 171 Q7DKV4 Q7DKV4_ECO57 Type 4 prepilin-like proteins leader peptide-processing enzyme (EC 2.1.1.-) etpN ECO57PM12 238 Bacterial secretion system* Escherichia coli O157:H7 172 Q8X2R8 Q8X2R8_ECO57 Replication protein P ECs1190 483 DNA replication Escherichia coli O157:H7 173 Q8X4I9 ALR2_ECO57 Alanine racemase, catabolic (EC 5.1.1.1) dadX dadB Z1953 ECs1685 356 D-Alanine metabolism* Escherichia coli O157:H7 174 Q8X4N9 Q8X4N9_ECO57 Permease of putrescine transport protein (Putrescine transport protein; permease) potI ECs0937 Z1084 281 ABC transporters Escherichia coli O157:H7 175 Q8X4Q2 Q8X4Q2_ECO57 Putative oxidoreductase major subunit (Putative oxidoreductase, major subunit) ECs2293 Z2575 808 Selenocompound metabolism Escherichia coli O157:H7 176 Q8X4R2 GATY_ECO57 D-tagatose-1,6-bisphosphate aldolase subunit GatY (TBPA) (TagBP aldolase) (EC 4.1.2.40) (D-tagatose-bisphosphategatY Z3259 ECs2899 aldolase class II) (Tagatose-bisphosphate aldolase)284 Galactose metabolism Escherichia coli O157:H7 177 Q8X523 Q8X523_ECO57 DNA polymerase III delta subunit (DNA polymerase III, delta subunit) holA ECs0678 Z0787 343 Purine metabolism Escherichia coli O157:H7 Pyrimidine metabolism DNA replication Mismatch repair Homologous recombination 178 Q8X584 Q8X584_ECO57 Putative ABC transporter permease protein (Putative iron compound ABC transporter, permeaseECs1698 protein) Z1965 326 ABC transporters Escherichia coli O157:H7 179 Q8X5C8 Q8X5C8_ECO57 Anthranilate synthase component I ECs1836 520 Phenylalanine, tyrosine and tryptophan biosynthesis Escherichia coli O157:H7 180 Q8X5I2 Q8X5I2_ECO57 Taurine dioxygenase (Taurine dioxygenase, 2-oxoglutarate-dependent) tauD ECs0422 Z0467 283 Taurine and hypotaurine metabolism Escherichia coli O157:H7 181 Q8X5J1 Q8X5J1_ECO57 Periplasmic ferric iron-binding protein (Putative periplasmic-iron-binding protein) afuA ECs0415 Z0460 343 ABC transporters Escherichia coli O157:H7 182 Q8X5J2 Q8X5J2_ECO57 Putative ferric transport system permease (Putative permease component of transport system forafuB ferric ECs0414 iron) Z0459 692 ABC transporters Escherichia coli O157:H7 183 Q8X5K2 Q8X5K2_ECO57 3-methyl-adenine DNA glycosylase I (3-methyladenine DNA glycosylase I) tag ECs4434 Z4974 187 Base excision repair Escherichia coli O157:H7 184 Q8X5T4 Q8X5T4_ECO57 Formate-dependent nitrite reductase NrfB (Formate-dependent nitrite reductase; a penta-haemenrfB cytochrome ECs5053 c)Z5670 190 Nitrogen metabolism* Escherichia coli O157:H7 185 Q8X5V2 ALR1_ECO57 Alanine racemase, biosynthetic (EC 5.1.1.1) alr Z5651 ECs5035 359 D-Alanine metabolism* Escherichia coli O157:H7 186 Q8X5V3 DNAB_ECO57 Replicative DNA helicase (EC 3.6.4.12) dnaB Z5650 ECs5034 471 DNA replication Escherichia coli O157:H7 187 Q8X5W4 AROH_ECO57 Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive (EC 2.5.1.54) (3-deoxy-D-arabino-heptulosonatearoH Z2733 ECs2411 7-phosphate synthase) (DAHP synthase) (Phospho-2-keto-3-deoxyheptonate348 Phenylalanine, aldolase)tyrosine and tryptophan biosynthesis Escherichia coli O157:H7 188 Q8X610 META_ECO57 Homoserine O-succinyltransferase (EC 2.3.1.46) (Homoserine O-transsuccinylase) (HTS) metA Z5599 ECs4931 309 Cysteine and methionine metabolism Escherichia coli O157:H7 Sulfur metabolism 189 Q8X622 Q8X622_ECO57 Riboflavin synthase alpha chain (Riboflavin synthase, alpha chain) ribE ECs2371 Z2688 213 Riboflavin metabolism Escherichia coli O157:H7 190 Q8X641 Q8X641_ECO57 Galactose-binding transport protein (Galactose-binding transport protein; receptor for galactosemglB taxis) ECs3042 Z3405 332 ABC transporters Escherichia coli O157:H7 Bacterial chemotaxis* 191 Q8X663 Q8X663_ECO57 PTS system, maltose and glucose-specific II ABC malX ECs2329 Z2626 530 Glycolysis / Gluconeogenesis Escherichia coli O157:H7 Starch and sucrose metabolism 192 Q8X6A8 Q8X6A8_ECO57 Carbamate kinase yahI ECs0372 Z0412 316 Purine metabolism Escherichia coli O157:H7 Arginine and proline metabolism 193 Q8X6J0 YAGS_ECO57 Putative xanthine dehydrogenase YagS FAD-binding subunit (EC 1.17.1.4) yagS Z0351 ECs0315 318 Purine metabolism Escherichia coli O157:H7 194 Q8X6M7 Q8X6M7_ECO57 DNA helicase RecC (DNA helicase, ATP-dependent dsDNA/ssDNA exonuclease V subunit, ssDNArecC ECs3679 endonuclease) Z4139 1122 Homologous recombination Escherichia coli O157:H7 195 Q8X6N9 Q8X6N9_ECO57 Arginine 3rd transport system periplasmic binding protein artI ECs0946 Z1093 243 ABC transporters Escherichia coli O157:H7 196 Q8X6Q3 Q8X6Q3_ECO57 Putative transport protein ECs0940 Z1087 447 Ascorbate and aldarate metabolism Escherichia coli O157:H7 Phosphotransferase system* 197 Q8X6Q9 Q8X6Q9_ECO57 Permease of putrescine transport protein (Putrescine transport protein; permease) potH ECs0936 Z1083 317 ABC transporters Escherichia coli O157:H7 198 Q8X6R6 Q8X6R6_ECO57 Cell division membrane protein (Cell division membrane protein FtsX) ftsX ECs4311 Z4836 352 ABC transporters Escherichia coli O157:H7 199 Q8X6S0 Q8X6S0_ECO57 L-serine dehydratase (L-serine dehydratase (Deaminase), L-SD2) sdaB ECs3657 Z4114 455 Glycine, serine and threonine metabolism Escherichia coli O157:H7 Cysteine and methionine metabolism 200 Q8X6V6 GSID_ECO57 Glutathione transport system permease protein gsiD gsiD Z1056 ECs0911 303 ABC transporters Escherichia coli O157:H7 201 Q8X6V9 GSIB_ECO57 Glutathione-binding protein gsiB gsiB Z1054 ECs0909 512 ABC transporters Escherichia coli O157:H7 202 Q8X6X9 THIC_ECO57 Phosphomethylpyrimidine synthase (EC 4.1.99.17) (Hydroxymethylpyrimidine phosphate synthase)thiC Z5569 (HMP-P ECs4917 synthase) (HMP-phosphate synthase) (HMPP synthase) (Thiamine631 Thiamine biosynthesis metabolism protein ThiC) Escherichia coli O157:H7 203 Q8X710 Q8X710_ECO57 4-alpha-glucanotransferase (4-alpha-glucanotransferase (Amylomaltase)) malQ ECs4258 Z4771 694 Starch and sucrose metabolism Escherichia coli O157:H7 204 Q8X711 MURB_ECO57 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) (UDP-N-acetylmuramate dehydrogenase)murB Z5543 ECs4899 342 Amino sugar and nucleotide sugar metabolism Escherichia coli O157:H7 Peptidoglycan biosynthesis* 205 Q8X726 Q8X726_ECO57 Putative amino acid amidohydrolase (Putative hippuricase) ECs4892 Z5522 388 Phenylalanine metabolism Escherichia coli O157:H7 206 Q8X732 ARGC_ECO57 N-acetyl-gamma-glutamyl-phosphate reductase (AGPR) (EC 1.2.1.38) (N-acetyl-glutamate semialdehydeargC Z5516 ECs4887dehydrogenase) (NAGSA dehydrogenase) 334 Arginine and proline metabolism Escherichia coli O157:H7 207 Q8X743 CAPP_ECO57 Phosphoenolpyruvate carboxylase (PEPC) (PEPCase) (EC 4.1.1.31) ppc Z5514 ECs4885 883 Pyruvate metabolism Escherichia coli O157:H7 Methane metabolism* 208 Q8X770 Q8X770_ECO57 Response transcriptional regulatory protein (RstB sensor) (Response transcriptional regulatoryrstA protein ECs2314 RstB Z2609sensor) 242 Two-component system* Escherichia coli O157:H7 209 Q8X779 Q8X779_ECO57 Primosomal protein N' (Primosomal protein N'(= factor Y)(Putative helicase)) priA ECs4862 Z5482 732 Homologous recombination Escherichia coli O157:H7 210 Q8X7A1 Q8X7A1_ECO57 Fructose-1,6-bisphosphatase glpX ECs4850 Z5470 336 Glycolysis / Gluconeogenesis Escherichia coli O157:H7 Pentose phosphate pathway Fructose and mannose metabolism 211 Q8X7B5 TRPA_ECO57 Tryptophan synthase alpha chain (EC 4.2.1.20) trpA Z2551 ECs1832 268 Glycine, serine and threonine metabolism Escherichia coli O157:H7 Phenylalanine, tyrosine and tryptophan biosynthesis 212 Q8X7B6 TRPB_ECO57 Tryptophan synthase beta chain (EC 4.2.1.20) trpB Z2550 ECs1833 397 Glycine, serine and threonine metabolism Escherichia coli O157:H7 Phenylalanine, tyrosine and tryptophan biosynthesis 213 Q8X7B7 TRPC_ECO57 Tryptophan biosynthesis protein TrpCF [Includes: Indole-3-glycerol phosphate synthase (IGPS)trpC (EC Z2549 4.1.1.48); ECs1834 N-(5'-phospho-ribosyl)anthranilate isomerase (PRAI) (EC452 5.3.1.24)]Phenylalanine, tyrosine and tryptophan biosynthesis Escherichia coli O157:H7 214 Q8X7C2 Q8X7C2_ECO57 Cob(I)alamin adenolsyltransferase btuR ECs1842 Z2540 196 Porphyrin and chlorophyll metabolism Escherichia coli O157:H7 215 Q8X7G5 Q8X7G5_ECO57 Phosphomethylpyrimidine kinase thiD ECs2906 Z3267 266 Thiamine metabolism Escherichia coli O157:H7 216 Q8X7N8 Q8X7N8_ECO57 Aminoacyl-histidine dipeptidase (Peptidase D) (Aminoacyl-histidine dipeptidase PepD) pepD ECs0264 Z0298 485 Glutathione metabolism Escherichia coli O157:H7 217 Q8X7X4 CYSD_ECO57 Sulfate adenylyltransferase subunit 2 (EC 2.7.7.4) (ATP-sulfurylase small subunit) (Sulfate adenylatecysD Z4060 transferase) ECs3606 (SAT) 302 Purine metabolism Escherichia coli O157:H7 Selenocompound metabolism Sulfur metabolism 218 Q8X7Y5 Q8X7Y5_ECO57 DNA polymerase III epsilon subunit (DNA polymerase III, epsilon subunit) dnaQ ECs0211 Z0241 243 Purine metabolism Escherichia coli O157:H7 Pyrimidine metabolism DNA replication Mismatch repair Homologous recombination 219 Q8X809 Q8X809_ECO57 Peptidoglycan synthetase (Peptidoglycan synthetase; penicillin-binding protein 1A) mrcA ECs4238 Z4750 858 Peptidoglycan biosynthesis* Escherichia coli O157:H7 220 Q8X824 AROB_ECO57 3-dehydroquinate synthase (EC 4.2.3.4) aroB Z4742 ECs4231 362 Phenylalanine, tyrosine and tryptophan biosynthesis Escherichia coli O157:H7 221 Q8X825 BIOB_ECO57 Biotin synthase (EC 2.8.1.6) bioB Z0994 ECs0853 346 Biotin metabolism Escherichia coli O157:H7 222 Q8X883 TUSD_ECO57 Sulfurtransferase TusD (EC 2.8.1.-) (tRNA 2-thiouridine synthesizing protein D) tusD Z4703 ECs4196 128 Sulfur relay system Escherichia coli O157:H7 223 Q8X884 TUSC_ECO57 Protein TusC (tRNA 2-thiouridine synthesizing protein C) tusC Z4702 ECs4195 119 Sulfur relay system Escherichia coli O157:H7 224 Q8X885 TUSB_ECO57 Protein TusB (tRNA 2-thiouridine synthesizing protein B) tusB Z4701 ECs4194 95 Sulfur relay system Escherichia coli O157:H7 225 Q8X8A1 RHAD_ECO57 Rhamnulose-1-phosphate aldolase (EC 4.1.2.19) rhaD Z5446 ECs4829 274 Pentose and glucuronate interconversions Escherichia coli O157:H7 Fructose and mannose metabolism 226 Q8X8D9 Q8X8D9_ECO57 Spermidine/putrescine periplasmic transport protein potD ECs1499 Z1762 348 ABC transporters Escherichia coli O157:H7 227 Q8X8E2 Q8X8E2_ECO57 Putative kinase ycfW ECs1496 Z1759 414 ABC transporters Escherichia coli O157:H7 228 Q8X8F9 AROE_ECO57 Shikimate dehydrogenase (EC 1.1.1.25) aroE Z4652 ECs4147 272 Phenylalanine, tyrosine and tryptophan biosynthesis Escherichia coli O157:H7 229 Q8X8L5 METE_ECO57 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) (Cobalamin-independentmetE Z5351 ECs4759 methionine synthase) (Methionine synthase, vitamin-B12753 independentCysteine andisozyme) methionine metabolism Escherichia coli O157:H7 Selenocompound metabolism 230 Q8X8N8 PYRC_ECO57 Dihydroorotase (DHOase) (EC 3.5.2.3) pyrC Z1699 ECs1440 348 Pyrimidine metabolism Escherichia coli O157:H7 231 Q8X8P5 Q8X8P5_ECO57 DNA-dependent ATPase I and helicase II uvrD ECs4743 Z5330 720 Nucleotide excision repair Escherichia coli O157:H7 Mismatch repair 232 Q8X8T3 HISX_ECO57 Histidinol dehydrogenase (HDH) (EC 1.1.1.23) hisD Z3182 ECs2821 434 Histidine metabolism Escherichia coli O157:H7 233 Q8X8T4 HIS1_ECO57 ATP phosphoribosyltransferase (ATP-PRT) (ATP-PRTase) (EC 2.4.2.17) hisG Z3181 ECs2820 299 Histidine metabolism Escherichia coli O157:H7 234 Q8X8V9 METQ_ECO57 D-methionine-binding lipoprotein metQ metQ Z0209 ECs0199 271 ABC transporters Escherichia coli O157:H7 235 Q8X8X5 DPO3A_ECO57 DNA polymerase III subunit alpha (EC 2.7.7.7) dnaE Z0196 ECs0186 1160 Purine metabolism Escherichia coli O157:H7 Pyrimidine metabolism DNA replication Mismatch repair Homologous recombination 236 Q8X8X7 LPXB_ECO57 Lipid-A-disaccharide synthase (EC 2.4.1.182) lpxB Z0194 ECs0184 382 Lipopolysaccharide biosynthesis* Escherichia coli O157:H7 237 Q8X8X8 LPXA_ECO57 Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (UDP-N-acetylglucosaminelpxA Z0193 acyltransferase) ECs0183 (EC 2.3.1.129) 262 Lipopolysaccharide biosynthesis* Escherichia coli O157:H7 238 Q8X8Y1 DXR_ECO57 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXP reductoisomerase) (EC 1.1.1.267) (1-deoxyxylulose-5-phosphatedxr Z0184 ECs0175 reductoisomerase) (2-C-methyl-D-erythritol 4-phosphate398 Terpenoid synthase) backbone biosynthesis Escherichia coli O157:H7 239 Q8X8Y6 GLND_ECO57 [Protein-PII] uridylyltransferase (PII uridylyl-transferase) (EC 2.7.7.59) (UTase) (Uridylyl-removingglnD Z0177 enzyme) ECs0169 890 Two-component system* Escherichia coli O157:H7 240 Q8X8Y7 DAPD_ECO57 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (EC 2.3.1.117) (TetrahydrodipicolinatedapD Z0176 ECs0168N-succinyltransferase) (THDP succinyltransferase) (THP succinyltransferase)274 Lysine biosynthesis (Tetrahydropicolinate succinylase) Escherichia coli O157:H7 241 Q8X8Z5 Q8X8Z5_ECO57 Ferrichrome-iron transport protein fhuB (Hydroxamate-dependent iron uptake, cytoplasmic membranefhuB ECs0157 component) Z0164 660 ABC transporters Escherichia coli O157:H7 242 Q8X900 GSH1_ECO57 Glutamate--cysteine ligase (EC 6.3.2.2) (Gamma-ECS) (GCS) (Gamma-glutamylcysteine synthetase)gshA Z3989 ECs3550 518 Glutathione metabolism Escherichia coli O157:H7 243 Q8X903 Q8X903_ECO57 Peptidoglycan synthetase MrcB (Peptidoglycan synthetase; penicillin-binding protein 1B) mrcB ECs0153 Z0160 844 Peptidoglycan biosynthesis* Escherichia coli O157:H7 244 Q8X911 Q8X911_ECO57 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase)folK ECs0146 Z0153 160 Folate biosynthesis Escherichia coli O157:H7 245 Q8X929 PANB_ECO57 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11) (Ketopantoate hydroxymethyltransferase)panB Z0145 ECs0138 (KPHMT) 264 Pantothenate and CoA biosynthesis Escherichia coli O157:H7 246 Q8X930 PANC_ECO57 Pantothenate synthetase (PS) (EC 6.3.2.1) (Pantoate--beta-alanine ligase) (Pantoate-activatingpanC enzyme) Z0144 ECs0137 283 beta-Alanine metabolism Escherichia coli O157:H7 Pantothenate and CoA biosynthesis 247 Q8X935 Q8X935_ECO57 Putative PTS enzyme II B component yadI ECs0133 Z0140 146 Ascorbate and aldarate metabolism Escherichia coli O157:H7 Phosphotransferase system* 248 Q8X938 Q8X938_ECO57 Carbonic anhydrase (EC 4.2.1.1) yadF ECs0130 Z0137 220 Nitrogen metabolism* Escherichia coli O157:H7 249 Q8X946 Q8X946_ECO57 Glucose dehydrogenase gcd ECs0128 Z0134 796 Pentose phosphate pathway Escherichia coli O157:H7 250 Q8X963 NADA_ECO57 Quinolinate synthase A (EC 2.5.1.72) nadA Z0919 ECs0778 347 Nicotinate and nicotinamide metabolism Escherichia coli O157:H7 251 Q8X979 Q8X979_ECO57 Cytochrome d terminal oxidase polypeptide subunit I (Cytochrome d terminal oxidase, polypeptidecydA ECs0768subunit I) Z0900 523 Oxidative phosphorylation Escherichia coli O157:H7 Two-component system* 252 Q8X9A0 Q8X9A0_ECO57 Putative transport system permease protein yhdY ECs4143 Z4631 368 ABC transporters Escherichia coli O157:H7 253 Q8X9A1 Q8X9A1_ECO57 Putative cob(I)alamin adenosyltransferase (Putative corrinoid:ATP adenosyltransferase) ECs0756 Z0886 200 Porphyrin and chlorophyll metabolism Escherichia coli O157:H7 254 Q8X9E2 Q8X9E2_ECO57 Phospho-2-dehydro-3-deoxyheptonate aldolase (EC 2.5.1.54) (3-deoxy-D-arabino-heptulosonatearoF 7-phosphate ECs3464 Z3893 synthase) (DAHP synthase) (Phospho-2-keto-3-deoxyheptonate356 Phenylalanine, aldolase) tyrosine and tryptophan biosynthesis Escherichia coli O157:H7 255 Q8X9F8 ATKA_ECO57 Potassium-transporting ATPase A chain (EC 3.6.3.12) (ATP phosphohydrolase [potassium-transporting]kdpA Z0845 A chain)ECs0726 (Potassium-binding and translocating subunit A) (Potassium-translocating557 Two-component ATPase system* A chain) Escherichia coli O157:H7 256 Q8X9G2 Q8X9G2_ECO57 Regulator of kdp operon (Transcriptional effector) (Transcriptional regulator of kdp operon) kdpE ECs0722 Z0841 225 Two-component system* Escherichia coli O157:H7 257 Q8X9G9 NANE_ECO57 Putative N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9) (ManNAc-6-P epimerase)nanE Z4581 ECs4096 229 Amino sugar and nucleotide sugar metabolism Escherichia coli O157:H7 258 Q8X9I1 MTGA_ECO57 Monofunctional biosynthetic peptidoglycan transglycosylase (Monofunctional TGase) (EC 2.4.2.-)mtgA Z4571 ECs4087 242 Peptidoglycan biosynthesis* Escherichia coli O157:H7 259 Q8X9I8 Q8X9I8_ECO57 Phosphotransferase system enzyme IIA (Phosphotransferase system enzyme IIA, regulates N ptsNmetabolism) ECs4083 Z4567 163 Phosphotransferase system* Escherichia coli O157:H7 260 Q8X9I9 Q8X9I9_ECO57 RNA polymerase sigma-54 factor rpoN ECs4081 Z4565 477 Two-component system* Escherichia coli O157:H7 261 Q8X9J9 MURA_ECO57 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) (Enoylpyruvate transferase)murA (UDP-N-acetylglucosamine Z4552 ECs4068 enolpyruvyl transferase) (EPT) 419 Amino sugar and nucleotide sugar metabolism Escherichia coli O157:H7 Peptidoglycan biosynthesis* 262 Q8X9K8 Q8X9K8_ECO57 D-alanyl-D-alanine carboxypeptidase (D-alanyl-D-alanine carboxypeptidase, fraction B; penicillin-bindingdacB ECs4061 protein Z4544 4) 477 Peptidoglycan biosynthesis* Escherichia coli O157:H7 263 Q8X9L1 Q8X9L1_ECO57 7,8-dihydropteroate synthase folP ECs4056 Z4539 297 Folate biosynthesis Escherichia coli O157:H7 264 Q8X9W8 Q8X9W8_ECO57 Putative resistance protein ECs2052 Z2271 172 Phosphonate and phosphinate metabolism* Escherichia coli O157:H7 265 Q8X9Y1 Q8X9Y1_ECO57 Cryptic nitrate reductase 2 beta subunit (Cryptic nitrate reductase 2, beta subunit) narY ECs2070 Z2245 514 Nitrogen metabolism* Escherichia coli O157:H7 266 Q8X9Y2 Q8X9Y2_ECO57 Cryptic nitrate reductase 2 alpha subunit (Cryptic nitrate reductase 2, alpha subunit) narZ ECs2071 Z2244 1246 Nitrogen metabolism* Escherichia coli O157:H7 267 Q8X9Y8 MURG_ECO57 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosaminemurG Z0100 ECs0094 transferase (EC 2.4.1.227) (Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc355 Peptidoglycan biosynthesis* GlcNAc transferase) Escherichia coli O157:H7 268 Q8X9Y9 MURD_ECO57 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) (D-glutamic acid-adding enzyme)murD Z0098 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate ECs0092 synthetase) 438 D-Glutamine and D-glutamate metabolism Escherichia coli O157:H7 Peptidoglycan biosynthesis* 269 Q8X9Z1 Q8X9Z1_ECO57 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (EC 6.3.2.10) murF ECs0090 Z0096 452 Lysine biosynthesis Escherichia coli O157:H7 Peptidoglycan biosynthesis* 270 Q8X9Z2 MURE_ECO57 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) (Meso-A2pm-addingmurE Z0095 ECs0089 enzyme) (Meso-diaminopimelate-adding enzyme) (UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate495 Lysine biosynthesis ligase) (UDP-MurNAc-tripeptideEscherichia coli O157:H7synthetase) (UDP-N-acetylmuramyl-tripeptide synthetase) Peptidoglycan biosynthesis* 271 Q8X9Z5 Q8X9Z5_ECO57 Acetolactate synthase III small subunit (Acetolactate synthase III, valine sensitive, small subunit)ilvH ECs0082 Z0088 163 Valine, leucine and isoleucine biosynthesis Escherichia coli O157:H7 Butanoate metabolism Pantothenate and CoA biosynthesis C5-Branched dibasic acid metabolism* 272 Q8XA05 Q8XA05_ECO57 Putative transport system permease protein yabK ECs0071 Z0076 536 ABC transporters Escherichia coli O157:H7 273 Q8XA39 ACPS_ECO57 Holo-[acyl-carrier-protein] synthase (Holo-ACP synthase) (EC 2.7.8.7) (4'-phosphopantetheinylacpS transferase dpj Z3844 AcpS) ECs3429 126 Pantothenate and CoA biosynthesis Escherichia coli O157:H7 274 Q8XA48 LSPA_ECO57 Lipoprotein signal peptidase (EC 3.4.23.36) (Prolipoprotein signal peptidase) (Signal peptidaselspA II) Z0031(SPase ECs0030II) 164 Protein export Escherichia coli O157:H7 275 Q8XA73 HCAF_ECO57 3-phenylpropionate/cinnamic acid dioxygenase subunit beta (EC 1.14.12.19) (Digoxigenin subunithcaF Z3810beta) ECs3405 172 Phenylalanine metabolism Escherichia coli O157:H7 276 Q8XA84 Q8XA84_ECO57 Aspartokinase I, homoserine dehydrogenase I (Aspartokinase I-homoserine dehydrogenase I)thrA ECs0002 Z0002 820 Glycine, serine and threonine metabolism Escherichia coli O157:H7 Cysteine and methionine metabolism Lysine biosynthesis 277 Q8XAB8 Q8XAB8_ECO57 Galactosamine-specific PTS system enzyme IIB component (PTS system, cytoplasmic, N-acetylgalactosamine-specificagaB ECs4018 Z4492 IIB component 1 (EIIB-AGA)) 158 Galactose metabolism Escherichia coli O157:H7 Phosphotransferase system* 278 Q8XAF1 TDCD_ECO57 Propionate kinase (EC 2.7.2.15) tdcD Z4467 ECs3995 402 Propanoate metabolism Escherichia coli O157:H7 279 Q8XAF2 Q8XAF2_ECO57 Probable formate acetyltransferase 3 (Putative formate acetyltransferase 3) tdcE ECs3994 Z4466 764 Pyruvate metabolism Escherichia coli O157:H7 Propanoate metabolism Butanoate metabolism 280 Q8XAG0 URE1_ECO57 Urease subunit alpha (EC 3.5.1.5) (Urea amidohydrolase subunit alpha) ureC1 Z1145 ECs1324; ureC2 Z1584 568 Purine metabolism Escherichia coli O157:H7 Arginine and proline metabolism 281 Q8XAG1 URE2_ECO57 Urease subunit beta (EC 3.5.1.5) (Urea amidohydrolase subunit beta) ureB1 Z1144 ECs1323; ureB2 Z1583 106 Purine metabolism Escherichia coli O157:H7 Arginine and proline metabolism 282 Q8XAG2 URE3_ECO57 Urease subunit gamma (EC 3.5.1.5) (Urea amidohydrolase subunit gamma) ureA1 Z1143 ECs1322; ureA2 Z1582 100 Purine metabolism Escherichia coli O157:H7 Arginine and proline metabolism 283 Q8XAG6 Q8XAG6_ECO57 Putative diacylglycerol kinase ECs1316 Z1139 Z1578 119 Glycerolipid metabolism Escherichia coli O157:H7 Glycerophospholipid metabolism 284 Q8XAP1 CYAA_ECO57 Adenylate cyclase (EC 4.6.1.1) (ATP pyrophosphate-lyase) (Adenylyl cyclase) cyaA Z5322 ECs4736 848 Purine metabolism Escherichia coli O157:H7 285 Q8XAP5 Q8XAP5_ECO57 Uroporphyrinogen III synthase hemD ECs4734 Z5318 246 Porphyrin and chlorophyll metabolism Escherichia coli O157:H7 286 Q8XAT5 GPPA_ECO57 Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC 3.6.1.40) (Guanosine pentaphosphategppA Z5289 phosphohydrolase) ECs4712 (pppGpp-5'-phosphohydrolase) 494 Purine metabolism Escherichia coli O157:H7 287 Q8XAV1 ILVD_ECO57 Dihydroxy-acid dehydratase (DAD) (EC 4.2.1.9) ilvD Z5282 ECs4705 616 Valine, leucine and isoleucine biosynthesis Pantothenate and CoA biosynthesis 288 Q8XB03 Q8XB03_ECO57 High-affinity phosphate-specific transport system; periplasmic phosphate-binding protein (Phosphate-bindingpstS ECs4664 Z5219 periplasmic protein PstS) 346 ABC transporters Escherichia coli O157:H7 Two-component system* 289 Q8XB09 Q8XB09_ECO57 Catabolic regulation response regulator creB ECs5356 Z6001 229 Two-component system* Escherichia coli O157:H7 290 Q8XB47 Q8XB47_ECO57 DNA polymerase III psi subunit (DNA polymerase III, psi subunit) holD ECs5330 Z5973 137 Purine metabolism Escherichia coli O157:H7 Pyrimidine metabolism DNA replication Mismatch repair Homologous recombination 291 Q8XB55 DNAT_ECO57 Primosomal protein 1 (Primosomal protein I) dnaT Z5962 ECs5322 179 Homologous recombination Escherichia coli O157:H7 292 Q8XBA3 Q8XBA3_ECO57 Flagellar biosynthesis, component of motor switch and energizing, enabling rotation and determiningfliN ECs2685 its direction Z3036 (Flagellar motor switch protein FliN) 137 Bacterial chemotaxis* Escherichia coli O157:H7 Flagellar assembly* 293 Q8XBA8 Q8XBA8_ECO57 Flagellar fliJ protein fliJ ECs2681 Z3032 147 Flagellar assembly* Escherichia coli O157:H7 294 Q8XBC8 Q8XBC8_ECO57 Putative transport system permease protein (Putative transport system permease protein (FormeryecS yecC)) ECs2656 Z3006 222 ABC transporters Escherichia coli O157:H7 295 Q8XBG3 Q8XBG3_ECO57 Ethanolamine utilization protein EutI (Ethanolamine utilization; homolog of Salmonella acetyl/butyryleutI ECs3320 P transferase) Z3714 338 Pyruvate metabolism Escherichia coli O157:H7 296 Q8XBJ6 Q8XBJ6_ECO57 Sulfate transport system permease T protein (Sulfate, thiosulfate transport system permease T cysUprotein) ECs3295 Z3689 277 ABC transporters Escherichia coli O157:H7 297 Q8XBL1 Q8XBL1_ECO57 Glucose-specific PTS system IIA component (PTS system, glucose-specific IIA component) crr ECs3289 Z3683 169 Glycolysis / Gluconeogenesis Escherichia coli O157:H7 Starch and sucrose metabolism Amino sugar and nucleotide sugar metabolism Phosphotransferase system* 298 Q8XBL2 Q8XBL2_ECO57 Putative kinase ygiG ECs3941 Z4411 123 Folate biosynthesis Escherichia coli O157:H7 299 Q8XBL3 Q8XBL3_ECO57 Phosphoenolpyruvate-protein phosphotransferase (EC 2.7.3.9) (Phosphotransferase system, enzymeptsI ECs3288 I) Z3682 575 Phosphotransferase system* Escherichia coli O157:H7 300 Q8XBQ7 Q8XBQ7_ECO57 Putative iron compound permease protein of ABC transporter family (Putative permease of ferrichromeECs3915 Z4384 ABC transporter) 327 ABC transporters Escherichia coli O157:H7 301 Q8XBS3 QSEB_ECO57 Transcriptional regulatory protein qseB qseB Z4377 ECs3907 219 Two-component system* Escherichia coli O157:H7 302 Q8XBV5 Q8XBV5_ECO57 Ferric enterobactin (Enterochelin) transport fepD ECs0629 Z0732 334 ABC transporters Escherichia coli O157:H7 303 Q8XBV6 Q8XBV6_ECO57 Ferric enterobactin transport protein fepG ECs0628 Z0731 330 ABC transporters Escherichia coli O157:H7 304 Q8XBZ3 DNAA_ECO57 Chromosomal replication initiator protein DnaA dnaA Z5193 ECs4637 467 Two-component system* Escherichia coli O157:H7 305 Q8XC30 Q8XC30_ECO57 Probable third cytochrome oxidase subunit II (Probable third cytochrome oxidase, subunit II)appB ECs1135 Z1396 378 Oxidative phosphorylation Escherichia coli O157:H7 Two-component system* 306 Q8XC31 Q8XC31_ECO57 Probable third cytochrome oxidase subunit I (Probable third cytochrome oxidase, subunit I) appC ECs1134 Z1395 514 Oxidative phosphorylation Escherichia coli O157:H7 Two-component system* 307 Q8XC50 NLPA_ECO57 Lipoprotein 28 nlpA Z5147 ECs4595 272 ABC transporters Escherichia coli O157:H7 308 Q8XCA4 Q8XCA4_ECO57 Putative uncharacterized protein ECs5239 (Putative uncharacterized protein yjgQ) yjgQ ECs5239 Z5874 361 ABC transporters Escherichia coli O157:H7 309 Q8XCB1 Q8XCB1_ECO57 DNA polymerase III chi subunit (DNA polymerase III, chi subunit) holC ECs5236 Z5871 147 Purine metabolism Escherichia coli O157:H7 Pyrimidine metabolism DNA replication Mismatch repair Homologous recombination 310 Q8XCE2 Q8XCE2_ECO57 Anaerobic ribonucleoside-triphosphate reductase nrdD ECs5215 Z5848 712 Pyrimidine metabolism Escherichia coli O157:H7 311 Q8XCE9 Q8XCE9_ECO57 Proton conductor component of motor (Proton conductor component of motor; no effect on switching)motA ECs2600 Z2944 295 Two-component system* Escherichia coli O157:H7 Bacterial chemotaxis* Flagellar assembly* 312 Q8XCF5 Q8XCF5_ECO57 Sensory transducer kinase CheA (Sensory transducer kinase between chemo-signal receptors andcheA CheB ECs2598 and CheY) Z2942 654 Two-component system* Escherichia coli O157:H7 Bacterial chemotaxis* 313 Q8XCF8 Q8XCF8_ECO57 Response regulator for chemotaxis (Response regulator for chemotaxis; protein glutamate methyltransferase)cheR ECs2594 Z2938 286 Two-component system* Escherichia coli O157:H7 Bacterial chemotaxis* 314 Q8XCJ1 Q8XCJ1_ECO57 Putative adhesin yebL ECs2567 Z2909 328 ABC transporters Escherichia coli O157:H7 315 Q8XCJ3 Q8XCJ3_ECO57 Heat shock protein MsbB (Suppressor of htrB, heat shock protein) msbB ECs2565 Z2907 323 Lipopolysaccharide biosynthesis* Escherichia coli O157:H7 316 Q8XCU1 LPXH_ECO57 UDP-2,3-diacylglucosamine hydrolase (EC 3.6.1.54) (UDP-2,3-diacylglucosamine diphosphatase)lpxH Z0679 ECs0586 240 Lipopolysaccharide biosynthesis* Escherichia coli O157:H7 317 Q8XCU8 Q8XCU8_ECO57 Phosphate acetyltransferase (EC 2.3.1.8) (Phosphotransacetylase) pta ECs3181 Z3559 714 Taurine and hypotaurine metabolism Escherichia coli O157:H7 Pyruvate metabolism Propanoate metabolism Methane metabolism* 318 Q8XCV4 Q8XCV4_ECO57 Phosphoribosylaminoimidazole carboxylase (Phosphoribosylaminoimidazole carboxylase = AIRpurK carboxylase, ECs0584 Z0677 CO(2)-fixing subunit) 355 Purine metabolism Escherichia coli O157:H7 319 Q8XCV5 ARCC_ECO57 Carbamate kinase (EC 2.7.2.2) arcC Z0676 ECs0583 297 Purine metabolism Escherichia coli O157:H7 Arginine and proline metabolism Nitrogen metabolism* 320 Q8XCW0 Q8XCW0_ECO57 Glycerate kinase (Putative uncharacterized protein ybbZ) ybbZ ECs0576 Z0669 381 Glycine, serine and threonine metabolism Escherichia coli O157:H7 Glycerolipid metabolism Glyoxylate and dicarboxylate metabolism 321 Q8XD78 Q8XD78_ECO57 Carbamate kinase yqeA ECs3747 Z4213 310 Purine metabolism Escherichia coli O157:H7 Arginine and proline metabolism 322 Q8XD82 TUSE_ECO57 Sulfurtransferase TusE (EC 2.8.1.-) (tRNA 2-thiouridine synthesizing protein E) tusE Z1321 ECs1053 109 Sulfur relay system Escherichia coli O157:H7 323 Q8XDB7 Q8XDB7_ECO57 Glucosyltransferase I (Glucosyltransferase I; lipopolysaccharide core biosynthesis) rfaG ECs4506 Z5055 374 Lipopolysaccharide biosynthesis* Escherichia coli O157:H7 324 Q8XDC6 Q8XDC6_ECO57 Nitrate reductase 1 beta subunit (Nitrate reductase 1, beta subunit) narH ECs1730 Z2002 512 Nitrogen metabolism* Escherichia coli O157:H7 Two-component system* 325 Q8XDC8 Q8XDC8_ECO57 Nitrate reductase 1 alpha subunit (Nitrate reductase 1, alpha subunit) narG ECs1729 Z2001 1247 Nitrogen metabolism* Escherichia coli O157:H7 Two-component system* 326 Q8XDD3 Q8XDD3_ECO57 Heptosyl transferase I (Heptosyl transferase I; lipopolysaccharide core biosynthesis) rfaC ECs4499 Z5048 330 Lipopolysaccharide biosynthesis* Escherichia coli O157:H7 327 Q8XDD5 Q8XDD5_ECO57 ADP-heptose--lps heptosyltransferase II (ADP-heptose--lps heptosyltransferase II; lipopolysacchariderfaF ECs4498 core biosynthesis)Z5047 348 Lipopolysaccharide biosynthesis* Escherichia coli O157:H7 328 Q8XDE7 KDSA_ECO57 2-dehydro-3-deoxyphosphooctonate aldolase (EC 2.5.1.55) (3-deoxy-D-manno-octulosonic acidkdsA 8-phosphate Z1986 ECs1720 synthase) (KDO-8-phosphate synthase) (KDO 8-P synthase)284 (KDOPS)Lipopolysaccharide (Phospho-2-dehydro-3-deoxyoctonate biosynthesis* aldolase) Escherichia coli O157:H7 329 Q8XDE9 GPMI_ECO57 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (BPG-independent PGAM) (Phosphoglyceromutase)gpmI Z5039 ECs4490 (iPGM) (EC 5.4.2.1) 514 Glycolysis / Gluconeogenesis Escherichia coli O157:H7 Glycine, serine and threonine metabolism Methane metabolism* 330 Q8XDF1 Q8XDF1_ECO57 Outer membrane protein 1a (Outer membrane protein 1a (Ia;b;F)) ompF ECs1012 Z1276 362 Two-component system* Escherichia coli O157:H7 331 Q8XDH0 LPXK_ECO57 Tetraacyldisaccharide 4'-kinase (EC 2.7.1.130) (Lipid A 4'-kinase) lpxK Z1261 ECs0998 328 Lipopolysaccharide biosynthesis* Escherichia coli O157:H7 332 Q8XDJ5 ULAA_ECO57 Ascorbate-specific permease IIC component ulaA (Ascorbate-specific PTS system EIIC component)ulaA Z5802 ECs5169 465 Ascorbate and aldarate metabolism Escherichia coli O157:H7 Phosphotransferase system* 333 Q8XDU4 Q8XDU4_ECO57 2-component regulatory system regulatory protein BasR (Transcriptional regulatory protein 2-componentbasR ECs5095 regulatory Z5715 system member) 222 Two-component system* Escherichia coli O157:H7 334 Q8XDX8 MEND_ECO57 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (SEPHCHC synthase)menD (EC Z3524 2.2.1.9) ECs3152 (Menaquinone biosynthesis protein MenD) 556 Ubiquinone and other terpenoid-quinone biosynthesis Escherichia coli O157:H7 335 Q8XDZ9 NADE_ECO57 NH(3)-dependent NAD(+) synthetase (EC 6.3.1.5) nadE Z2770 ECs2446 275 Nicotinate and nicotinamide metabolism Escherichia coli O157:H7 336 Q8XE07 RHMD_ECO57 L-rhamnonate dehydratase (RhamD) (EC 4.2.1.90) rhmD Z3505 ECs3135 405 Fructose and mannose metabolism Escherichia coli O157:H7 337 Q8XE13 GLPB_ECO57 Anaerobic glycerol-3-phosphate dehydrogenase subunit B (Anaerobic G-3-P dehydrogenase subunitglpB Z3500 B) (Anaerobic ECs3127 G3Pdhase B) (EC 1.1.5.3) 419 Glycerophospholipid metabolism Escherichia coli O157:H7 338 Q8XE41 OMPC_ECO57 Outer membrane protein C (Outer membrane protein 1B) (Porin OmpC) ompC Z3473 ECs3104 367 Two-component system* Escherichia coli O157:H7 339 Q8XE48 Q8XE48_ECO57 Ferredoxin-type protein (Ferredoxin-type protein: electron transfer) napG ECs3094 Z3462 231 Nitrogen metabolism* Escherichia coli O157:H7 340 Q8XE56 Q8XE56_ECO57 Ferredoxin-type protein (Ferredoxin-type protein: electron transfer) napH ECs3093 Z3461 287 Nitrogen metabolism* Escherichia coli O157:H7 341 Q8XE66 Q8XE66_ECO57 Nitrate/nitrite response regulator (Sensor NarQ) (Nitrate/nitrite response regulator NarP) narP ECs3082 Z3450 215 Two-component system* Escherichia coli O157:H7 342 Q8XE69 RL25_ECO57 50S ribosomal protein L25 rplY Z3444 ECs3077 94 Ribosome Escherichia coli O157:H7 343 Q8XE86 Q8XE86_ECO57 Phosphatidylglycerophosphatase pgpA ECs0471 Z0520 171 Glycerophospholipid metabolism Escherichia coli O157:H7 344 Q8XE87 THIL_ECO57 Thiamine-monophosphate kinase (TMP kinase) (Thiamine-phosphate kinase) (EC 2.7.4.16) thiL Z0519 ECs0470 325 Thiamine metabolism Escherichia coli O157:H7 345 Q8XE88 Q8XE88_ECO57 Bifunctional pyrimidine deaminase/reductase in pathway of riboflavin synthesis ribD ECs0467 Z0515 367 Riboflavin metabolism Escherichia coli O157:H7 346 Q8XE91 Q8XE91_ECO57 Fructose-specific PTS transport system protein (PTS system, fructose-specific transport protein)fruA ECs3059 Z3425 563 Fructose and mannose metabolism Escherichia coli O157:H7 Phosphotransferase system* 347 Q8XE99 Q8XE99_ECO57 Positive and negative sensor protein for pho regulon (Positive and negative sensor protein for phoRpho regulon ECs0450 PhoR) Z0498 431 Two-component system* Escherichia coli O157:H7 348 Q8XEB4 Q8XEB4_ECO57 Formate acetyltransferase 1 pflB ECs0986 Z1248 760 Pyruvate metabolism Escherichia coli O157:H7 Propanoate metabolism Butanoate metabolism 349 Q9S5G3 HIS2_ECO57 Histidine biosynthesis bifunctional protein HisIE [Includes: Phosphoribosyl-AMP cyclohydrolasehisI hisIE(PRA-CH) Z3188 (EC ECs2827 3.5.4.19); Phosphoribosyl-ATP pyrophosphatase (PRA-PH)203 Histidine (EC 3.6.1.31)] metabolism Escherichia coli O157:H7 350 Q9S5G4 HIS4_ECO57 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamidehisA isomerase Z3186 ECs2825 (EC 5.3.1.16) (Phosphoribosylformimino-5-aminoimidazole carboxamide245 Histidine ribotide metabolism isomerase) Escherichia coli O157:H7

* represents targets from unique pathways Sub-Cellular Localization of 350 target proteins from common and unique pathways with molecular weight in Dalton, 3D structural information and similar to binding partners of FDA approved drugs, experimental small molecule compounds, or nutraceutical compounds as inferred using BLASTP

No UniProt ID Entry Name Protein Names Gene Names Associated metabolic pathways Subcellular localizationMolecular weightDrugBank (Da) targets DrugBank ID ModBasePDB 1 O82884 O82884_ECO57 Type II secretion pathway related protein (Type II secretion protein)etpE ECO57PM03 L7034 Bacterial secretion system* Cytoplasmic 55,929 General secretion pathway protein E ; DB04395 Yes No 2 P0A3L9 KITH_ECO57 Thymidine kinase (EC 2.7.1.21) tdk Z2015 ECs1740 Pyrimidine metabolism Cytoplasmic 23,399 No No 3 P0A4D1 RS6_ECO57 30S ribosomal protein S6 rpsF Z5809 ECs5176 Ribosome Cytoplasmic 15,187 Yes No 4 P0A6A5 ACKA_ECO57 Acetate kinase (EC 2.7.2.1) (Acetokinase) ackA ack Z3558 ECs3180 Taurine and hypotaurine metabolism Cytoplasmic 43,290 Yes No Pyruvate metabolism Propanoate metabolism Methane metabolism* 5 P0A6I2 KCY_ECO57 Cytidylate kinase (CK) (EC 2.7.4.25) (Cytidine monophosphate kinase)cmk mssA(CMP Z1256 kinase) ECs0993 Pyrimidine metabolism Cytoplasmic 24,746 Cytidylate kinase DB02456; DB02883; DB03403; DB04555 Yes No 6 P0A6I7 COAD_ECO57 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) (Dephospho-CoAcoaD pyrophosphorylase) kdtB Z5058 ECs4509 (Pantetheine-phosphatePantothenate and CoA adenylyltransferase) biosynthesis (PPAT) Cytoplasmic 17,837 Phosphopantetheine adenylyltransferase DB01992; DB03170; DB03912; DB03431 Yes No 7 P0A6K2 DAPF_ECO57 Diaminopimelate epimerase (DAP epimerase) (EC 5.1.1.7) dapF Z5326 ECs4739 Lysine biosynthesis Cytoplasmic 30,209 Yes No 8 P0A6K8 DEOB_ECO57 Phosphopentomutase (EC 5.4.2.7) (Phosphodeoxyribomutase) deoB drm thyR Z5985 ECs5342Pentose phosphate pathway Cytoplasmic 44,370 Yes No Purine metabolism 9 P0A6Q4 FABA_ECO57 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.60)fabA (Beta-hydroxydecanoyl Z1304 ECs1038 thioesterFatty acid dehydrase) biosynthesis Cytoplasmic 18,969 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase DB03813 Yes No 10 P0A6Q8 FABZ_ECO57 (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase ((3R)-hydroxymyristoylfabZ Z0192 ECs0182 ACP dehydrase)Fatty (ECacid 4.2.1.-) biosynthesis Cytoplasmic 17,033 DB07445; DB04216; DB06949; DB06950; DB06978; DB07044; DB07097; DB07098;Yes DB07352; No DB07715; DB08517 11 P0A6R2 FABH_ECO57 3-oxoacyl-[acyl-carrier-protein] synthase 3 (EC 2.3.1.180) (3-oxoacyl-[acyl-carrier-protein]fabH Z1730 ECs1469 synthaseFatty acid III) biosynthesis(Beta-ketoacyl-ACP synthase III) (KAS CytoplasmicIII) (EcFabH) 33,515 3-oxoacyl-[acyl-carrier-protein] synthase 3 DB01034; DB01992; DB02039; DB02316; DB03661; DB04524; DB07429; DB03264;Yes DB07611; No DB07650; DB08171; DB08684; DB08712 12 P0A6X2 HEM1_ECO57 Glutamyl-tRNA reductase (GluTR) (EC 1.2.1.70) hemA Z1981 ECs1715 Porphyrin and chlorophyll metabolism Cytoplasmic 46,307 Yes No 13 P0A6X5 HFQ_ECO57 Protein hfq (HF-1) (Host factor-I protein) (HF-I) hfq Z5779 ECs5148 RNA degradation Cytoplasmic 11,166 Yes No 14 P0A727 LPXC_ECO57 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (EClpxC 3.5.1.-) Z0106 (UDP-3-O-acyl-GlcNAcECs0100 Lipopolysaccharide deacetylase) biosynthesis* Cytoplasmic 33,956 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase DB07861; DB01991; DB04257; DB07355; DB07536; DB08231 Yes No 15 P0A732 MGSA_ECO57 Methylglyoxal synthase (MGS) (EC 4.2.3.3) mgsA Z1314 ECs1047 Pyruvate metabolism Cytoplasmic 16,919 Methylglyoxal synthase DB01942; DB02726; DB03026 Yes No 16 P0A740 MOAC_ECO57 Molybdenum cofactor biosynthesis protein C moaC chlA3 Z1002 ECs0861Folate biosynthesis Cytoplasmic 17,467 Yes No Sulfur relay system 17 P0A778 RPPH_ECO57 RNA pyrophosphohydrolase (EC 3.6.1.-) ((Di)nucleoside polyphosphaterppH nudHhydrolase) Z4147 ECs3687RNA degradation Cytoplasmic 20,795 Yes No 18 P0A795 PDXJ_ECO57 Pyridoxine 5'-phosphate synthase (PNP synthase) (EC 2.6.99.2) pdxJ Z3845 ECs3430 Vitamin B6 metabolism Cytoplasmic 26,384 Pyridoxine 5'-phosphate synthase DB02209; DB02496; DB02515 Yes No 19 P0A7B0 IPYR_ECO57 Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase)ppa Z5837 (PPase) ECs5204 Oxidative phosphorylation Cytoplasmic 19,704 Inorganic pyrophosphatase DB02212; DB06851; DB07291 Yes No 20 P0A7F1 PYRH_ECO57 Uridylate kinase (UK) (EC 2.7.4.22) (Uridine monophosphate kinase)pyrH (UMP Z0182 kinase) ECs0173 (UMPK) Pyrimidine metabolism Cytoplasmic 25,970 Yes No 21 P0A7F5 PYRI_ECO57 Aspartate carbamoyltransferase regulatory chain pyrI Z5855 ECs5221 Pyrimidine metabolism Unknown 17,121 Yes No Alanine, aspartate and glutamate metabolism 22 P0A7H2 RECF_ECO57 DNA replication and repair protein RecF recF uvrF Z5191 ECs4635 Homologous recombination Cytoplasmic 40,514 Yes No 23 P0A7I8 RIBA_ECO57 GTP cyclohydrolase-2 (EC 3.5.4.25) (GTP cyclohydrolase II) ribA Z2531 ECs1850 Riboflavin metabolism Cytoplasmic 21,836 Yes No 24 P0A7J1 RIBB_ECO57 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) ribB(EC 4.1.99.12)htrP Z4399 ECs3929 Riboflavin metabolism Cytoplasmic 23,353 Yes No 25 P0A7J5 RL10_ECO57 50S ribosomal protein L10 rplJ Z5558 ECs4908 Ribosome Cytoplasmic 17,712 50S ribosomal protein L10 DB00778; DB01190; DB01211; DB01369; DB01627 Yes No 26 P0A7L2 RL1_ECO57 50S ribosomal protein L1 rplA Z5557 ECs4907 Ribosome Cytoplasmic 24,730 Yes No 27 P0A7M4 RL28_ECO57 50S ribosomal protein L28 rpmB Z5061 ECs4512 Ribosome Cytoplasmic 9,006 Yes No 28 P0A7M8 RL29_ECO57 50S ribosomal protein L29 rpmC Z4683 ECs4177 Ribosome Cytoplasmic 7,273 Yes No 29 P0A7N0 RL31_ECO57 50S ribosomal protein L31 rpmE Z5484 ECs4863 Ribosome Cytoplasmic 7,871 Yes No 30 P0A7Q2 RL35_ECO57 50S ribosomal protein L35 rpmI Z2746 ECs2424 Ribosome Cytoplasmic 7,289 Yes No 31 P0A7U9 RS20_ECO57 30S ribosomal protein S20 rpsT Z0027 ECs0026 Ribosome Cytoplasmic 9,684 Yes No 32 P0A7W0 RS4_ECO57 30S ribosomal protein S4 rpsD ramA Z4666 ECs4161Ribosome Cytoplasmic 23,469 30S ribosomal protein S4 DB00254; DB00256; DB00453; DB00595; DB00618; DB01017; DB08185 Yes No 33 P0A7Z6 RPOA_ECO57 DNA-directed RNA polymerase subunit alpha (RNAP subunit alpha)rpoA (EC Z4665 2.7.7.6) ECs4160 (RNA polymerasePurine subunitmetabolism alpha) (Transcriptase subunit alpha)Cytoplasmic 36,512 DNA-directed RNA polymerase alpha chain ;DNA-directed RNA polymeraseDB00615; subunit DB08266; alpha; DB08226; Yes No Pyrimidine metabolism 34 P0A802 RPOZ_ECO57 DNA-directed RNA polymerase subunit omega (RNAP omega subunit)rpoZ (ECZ5075 2.7.7.6) ECs4524 (RNA polymerasePurine metabolism omega subunit) (Transcriptase subunit omega)Cytoplasmic 10,237 Yes No Pyrimidine metabolism RNA polymerase 35 P0A811 RUVA_ECO57 Holliday junction ATP-dependent DNA helicase RuvA (EC 3.6.4.12)ruvA Z2913 ECs2571 Homologous recombination Cytoplasmic 22,086 Yes No 36 P0A816 RUVC_ECO57 Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4) (HollidayruvC Z2915 junction ECs2573 nuclease RuvC)Homologous (Holliday recombination junction resolvase RuvC) Cytoplasmic 18,747 Yes No 37 P0A892 TUSA_ECO57 Sulfurtransferase TusA (EC 2.8.1.-) (tRNA 2-thiouridine synthesizingtusA protein Z4844 A) ECs4319 Sulfur relay system Cytoplasmic 9,095 Yes yes 38 P0A8Q4 FRDD_ECO57 Fumarate reductase subunit D (Fumarate reductase 13 kDa hydrophobicfrdD Z5758protein) ECs5132 Citrate cycle (TCA cycle) Membrane 13,107 Fumarate reductase subunit D DB07490; DB07918 Yes No Oxidative phosphorylation Butanoate metabolism Toluene degradation* Two-component system* 39 P0A966 CHEW_ECO57 Chemotaxis protein CheW cheW Z2941 ECs2597 Two-component system* Cytoplasmic 18,084 Yes No Bacterial chemotaxis* 40 P0A990 DPO3B_ECO57 DNA polymerase III subunit beta (EC 2.7.7.7) dnaN Z5192 ECs4636 Purine metabolism Cytoplasmic 40,587 DNA polymerase III subunit beta DB06998 Yes No Pyrimidine metabolism DNA replication Mismatch repair Homologous recombination 41 P0A9D6 CYSE_ECO57 Serine acetyltransferase (SAT) (EC 2.3.1.30) cysE Z5034 ECs4485 Cysteine and methionine metabolism Cytoplasmic 29,317 Serine acetyltransferase DB02078; DB01992 Yes No Sulfur metabolism 42 P0A9J9 PHEA_ECO57 P-protein [Includes: Chorismate mutase (CM) (EC 5.4.99.5); PrephenatepheA Z3891dehydratase ECs3462 (PDT) (ECPhenylalanine, 4.2.1.51)] tyrosine and tryptophan biosynthesisCytoplasmic 43,111 P-protein DB08648 Yes No 43 P0A9M6 XGPT_ECO57 Xanthine phosphoribosyltransferase (EC 2.4.2.22) (Xanthine-guaninegpt phosphoribosyltransferase)Z0299 ECs0265 Purine (XGPRT) metabolism Cytoplasmic 16,971 Xanthine phosphoribosyltransferase DB01972; DB02134; DB02377; DB03942 Yes No 44 P0A9Q3 ARCA_ECO57 Aerobic respiration control protein ArcA arcA Z6004 ECs5359 Two-component system* Cytoplasmic 27,292 Yes No 45 P0A9R0 DHAS_ECO57 Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (ASADH)asd Z4797 (EC ECs4278 1.2.1.11) (Aspartate-beta-semialdehydeGlycine, serine and threonine dehydrogenase) metabolism Cytoplasmic 40,018 Aspartate-semialdehyde dehydrogenase DB03461; DB03502; DB04498 Yes No Cysteine and methionine metabolism Lysine biosynthesis 46 P0A9Z3 GLNB_ECO57 Nitrogen regulatory protein P-II 1 glnB Z3829 ECs3419 Two-component system* Membrane 12,425 Yes No 47 P0AA06 PTHP_ECO57 Phosphocarrier protein HPr (EC 2.7.11.-) (Histidine-containing protein)ptsH Z3681 ECs3287 Phosphotransferase system* Cytoplasmic 9,119 Yes No 48 P0AA18 OMPR_ECO57 Transcriptional regulatory protein OmpR ompR Z4760 ECs4247 Two-component system* Cytoplasmic 27,354 Yes No 49 P0AAB0 ZRAP_ECO57 Zinc resistance-associated protein zraP Z5578 ECs4925 Two-component system* Membrane 15,199 Yes No 50 P0AAK8 NRFC_ECO57 Protein nrfC nrfC Z5671 ECs5054 Nitrogen metabolism* Cytoplasmic 24,567 NrfC protein DB08689 Yes No 51 P0AB72 ALF_ECO57 Fructose-bisphosphate aldolase class 2 (FBP aldolase) (FBPA) (ECfbaA 4.1.2.13) Z4263 (Fructose-1,6-bisphosphate ECs3796 Glycolysis aldolase) / Gluconeogenesis (Fructose-bisphosphate aldolaseCytoplasmic class II) 39,147 Fructose-bisphosphate aldolase class 2 DB03026 Yes No Pentose phosphate pathway Fructose and mannose metabolism Methane metabolism* 52 P0AB76 KBAY_ECO57 D-tagatose-1,6-bisphosphate aldolase subunit KbaY (TBPA) (TagBPkbaY aldolase) agaY Z4491(EC 4.1.2.40) ECs4017 (D-tagatose-bisphosphateGalactose metabolism aldolase class II) (Ketose 1,6-bisphosphateCytoplasmic aldolase31,294 class II) (Tagatose-bisphosphateTagatose-1,6-bisphosphate aldolase) aldolase agaY DB03026 Yes No 53 P0AB92 AROG_ECO57 Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive (EC aroG2.5.1.54) Z0924 (3-deoxy-D-arabino-heptulosonate ECs0782 Phenylalanine, tyrosine 7-phosphate and tryptophan synthase) biosynthesis(DAHP synthase)Cytoplasmic (Phospho-2-keto-3-deoxyheptonate38,010 Phospho-2-dehydro-3-deoxyheptonate aldolase) aldolase, Phe-sensitive DB01819; DB02726 Yes No 54 P0ABJ7 CYOD_ECO57 Cytochrome o ubiquinol oxidase protein CyoD (Ubiquinol oxidase cyoDchain Z0532D) ECs0483 Oxidative phosphorylation Membrane 12,029 Yes No 55 P0ABK4 CYDB_ECO57 Cytochrome d ubiquinol oxidase subunit 2 (EC 1.10.3.-) (CytochromecydB bd-I Z0901 oxidase ECs0769 subunit II) Oxidative(Cytochrome phosphorylation d ubiquinol oxidase subunit II) Membrane 42,453 Yes No Two-component system* 56 P0ABL0 NRFA_ECO57 Cytochrome c-552 (EC 1.7.2.2) (Ammonia-forming cytochrome c nitritenrfA Z5669 reductase) ECs5052 (CytochromeNitrogen c nitrite metabolism* reductase) Membrane 53,703 Cytochrome c-552 precursor;Cytochrome c-552 ;Cytochrome c nitriteDB03317; reductase, DB03014; catalytic subunitDB07918 NfrA, putative;Cytochrome c nitrite reductase catalytic subunitYes ; No 57 P0ABM3 CCMC_ECO57 Heme exporter protein C (Cytochrome c-type biogenesis protein CcmC)ccmC Z3456 ECs3088 ABC transporters Membrane 27,885 Yes No 58 P0ABN3 KDGL_ECO57 Diacylglycerol kinase (DAGK) (EC 2.7.1.107) (Diglyceride kinase)dgkA (DGK) Z5641 ECs5025 Glycerolipid metabolism Membrane 13,245 Yes No Glycerophospholipid metabolism 59 P0ABP9 DEOD_ECO57 Purine nucleoside phosphorylase DeoD-type (PNP) (EC 2.4.2.1) deoD Z5986 ECs5343 Purine metabolism Cytoplasmic 25,950 Purine nucleoside phosphorylase deoD-type;Purine nucleoside phosphorylaseDB02066; DB02113; DB02896; DB02934; DB02947; DB03172; DB03528; DB03735; YesDB03952;Yes DB03986; DB04198; DB04441; DB02857 Pyrimidine metabolism Nicotinate and nicotinamide metabolism 60 P0ABS6 PRIM_ECO57 DNA primase (EC 2.7.7.-) dnaG Z4419 ECs3949 DNA replication Cytoplasmic 65,565 Yes No 61 P0AC77 KDTA_ECO57 3-deoxy-D-manno-octulosonic-acid transferase (EC 2.4.-.-) (KDO waaAtransferase) kdtA Z5057 ECs4508Lipopolysaccharide biosynthesis* Unknown 47,291 Yes No 62 P0ACB6 HEMG_ECO57 Protoporphyrinogen IX dehydrogenase [menaquinone] (EC 1.3.5.3)hemG Z5372 ECs4778 Porphyrin and chlorophyll metabolism Unknown 21,226 Yes No 63 P0ACV1 HTRB_ECO57 Lipid A biosynthesis lauroyl acyltransferase (EC 2.3.1.-) (Heat shockhtrB protein waaM B) Z1690 ECs1432Lipopolysaccharide biosynthesis* Membrane 35,407 Yes No 64 P0AD00 CUSR_ECO57 Transcriptional regulatory protein CusR cusR Z0709 ECs0609 Two-component system* Cytoplasmic 25,395 Yes No 65 P0AD67 PBP2_ECO57 Penicillin-binding protein 2 (PBP-2) mrdA pbpA Z0781 ECs0673Peptidoglycan biosynthesis* Membrane 70,857 Penicillin-binding protein 2 ; Penicillin-binding protein 3 ;Penicillin bindingDB00303; protein DB00438; 2a ;Beta-lactam-inducible DB00948; DB01327; penicillin-binding DB01328; DB01329; protein DB01413; ;MecA PBP2' DB01415; (penicillinYes DB01598; bindingNo DB00671; protein 2') DB00923; ;Peptidoglycan DB01326; synthetase DB00355; ftsI ;DB00493; DB04570; DB00274; DB00430; DB01000; DB01607; DB02443; DB02968; DB04041; DB00535; DB00417; DB01332; DB01603; DB00267; DB00274; DB01331; DB01416 66 P0AD69 FTSI_ECO57 Peptidoglycan synthase FtsI (EC 2.4.1.129) (Penicillin-binding proteinftsI pbpB3) (PBP-3) Z0094 (Peptidoglycan ECs0088 Peptidoglycan glycosyltransferase biosynthesis* 3) Membrane 63,877 Penicillin-binding protein 2X ;Penicillin-binding protein 2x ;Penicillin-bindingDB00267; proteinDB00274; 3 ;Penicillin-binding DB00303; DB00430; protein DB00438; 2 ;Peptidoglycan DB01327; synthetase DB01328; ftsI DB01329; Yes DB01331;No DB01332; DB01413; DB01415; DB01416; DB00535; DB00948; DB01598; DB03190; DB00923; DB01326; DB00355; DB00493; DB04570; DB01150 67 P0ADC5 LOLC_ECO57 Lipoprotein-releasing system transmembrane protein LolC lolC Z1757 ECs1494 ABC transporters Membrane 43,264 Yes No 68 P0ADZ9 YAJC_ECO57 UPF0092 membrane protein YajC yajC Z0506 ECs0458 Protein export Membrane 11,887 Yes No Bacterial secretion system* 69 P0AE38 ASTA_ECO57 Arginine N-succinyltransferase (AST) (EC 2.3.1.109) (AOST) astA Z2779 ECs2453 Arginine and proline metabolism Cytoplasmic 38,456 Arginine N-succinyltransferase subunit alpha DB01942 Yes No 70 P0AE68 CHEY_ECO57 Chemotaxis protein CheY cheY Z2936 ECs2592 Two-component system* Cytoplasmic 14,097 Chemotaxis protein cheY DB02461; DB03487; DB04156 Yes No Bacterial chemotaxis* 71 P0AE75 CITT_ECO57 Citrate carrier (Citrate transporter) (Citrate/succinate antiporter) citT Z0756 ECs0651 Two-component system* Membrane 53,093 Yes No 72 P0AEA9 CYSG_ECO57 Siroheme synthase [Includes: Uroporphyrinogen-III C-methyltransferasecysG Z4729 (Urogen ECs4219 III methylase)Porphyrin (EC 2.1.1.107) and chlorophyll (SUMT) metabolism(Uroporphyrinogen III methylase)Cytoplasmic (UROM); Precorrin-249,951 dehydrogenaseSiroheme synthase (EC 1.3.1.76); ;Uroporphyrinogen-III Sirohydrochlorin C-methyltransferase ferrochelatase (EC ;Hypothetical 4.99.1.4)]DB01752; protein DB01907; TTHA0667 DB04522 Yes No 73 P0AEE9 DMA_ECO57 DNA adenine methylase (EC 2.1.1.72) (DNA adenine methyltransferase)dam Z4740 (Deoxyadenosyl-methyltransferase) ECs4229 Mismatch repair Cytoplasmic 32,100 Yes No 74 P0AEG3 DPPC_ECO57 Dipeptide transport system permease protein dppC dppC Z4959 ECs4422 ABC transporters Membrane 32,308 Yes No 75 P0AEQ8 GLNP_ECO57 Glutamine transport system permease protein glnP glnP Z1032 ECs0888 ABC transporters Membrane 24,364 Yes No 76 P0AEU5 HISM_ECO57 Histidine transport system permease protein hisM hisM Z3569 ECs3191 ABC transporters Membrane 26,870 Yes No 77 P0AEY4 MAZG_ECO57 Nucleoside triphosphate pyrophosphohydrolase (NTP-PPase) (EC 3.6.1.8)mazG Z4096 ECs3641 Purine metabolism Cytoplasmic 30,412 Yes No Pyrimidine metabolism 78 P0AF02 MODB_ECO57 Molybdenum transport system permease protein modB modB Z0934 ECs0792 ABC transporters Membrane 24,939 Yes No 79 P0AF14 MTNN_ECO57 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTA/SAHmtnN Z0170 nucleosidase) ECs0163 (MTAN)Cysteine (EC 3.2.2.9)and methionine (5'-methylthioadenosine metabolism nucleosidase)Cytoplasmic (MTA nucleosidase)24,354 (S-adenosylhomocysteine5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase) (AdoHcy nucleosidase) nucleosidase (SAH nucleosidase);MTA/SAHDB07649; nucleosidase; (SRH DB07463; nucleosidase) DB00173; DB02158; DB02281; DB02933; DB08606 Yes Yes 80 P0AF17 MURJ_ECO57 Protein MurJ homolog murJ mviN Z1707 ECs1447Peptidoglycan biosynthesis* Membrane 55,267 Yes No 81 P0AF30 NARL_ECO57 Nitrate/nitrite response regulator protein NarL narL Z1996 ECs1726 Two-component system* Cytoplasmic 23,927 Yes No 82 P0AFA0 LPTF_ECO57 Lipopolysaccharide export system permease protein lptF lptF Z5873 ECs5238 ABC transporters Membrane 40,358 Yes No 83 P0AFB0 NIKC_ECO57 Nickel transport system permease protein nikC nikC Z4870 ECs4345 ABC transporters Membrane 30,362 Yes No 84 P0AFB9 NTRC_ECO57 Nitrogen regulation protein NR(I) glnG Z5404 ECs4790 Two-component system* Cytoplasmic 52,255 Nitrogen regulation protein NR(I;Transcriptional regulator ;C4-dicarboxylateDB01857; transport DB03431; transcriptional DB04077; regulatory protein dctD ; Yes No 85 P0AFH7 OPPC_ECO57 Oligopeptide transport system permease protein oppC oppC Z2021 ECs1745 ABC transporters Membrane 33,022 Yes No 86 P0AFJ3 PHNA_ECO57 Protein phnA phnA Z5710 ECs5090 Phosphonate and phosphinate metabolism* Unknown 12,345 Yes No 87 P0AFJ6 PHOB_ECO57 Phosphate regulon transcriptional regulatory protein phoB phoB Z0497 ECs0449 Two-component system* Cytoplasmic 26,433 Yes No 88 P0AFK8 POTC_ECO57 Spermidine/putrescine transport system permease protein PotC potC Z1763 ECs1500 ABC transporters Membrane 29,111 Yes No 89 P0AFL8 PPX_ECO57 Exopolyphosphatase (ExopolyPase) (EC 3.6.1.11) (Metaphosphatase)ppx Z3765 ECs3364 Purine metabolism Cytoplasmic 58,136 Yes Yes 90 P0AFU5 QSEF_ECO57 Transcriptional regulatory protein QseF (Quorum-sensing regulatorqseF protein yfhA F) Z3830 ECs3420 Two-component system* Cytoplasmic 49,148 Transcriptional regulator ;Nitrogen regulation protein NR(I) ;C4-dicarboxylateDB04077; transportDB01857; transcriptional DB03431 regulatory protein dctD Yes No 91 P0AG04 UBIX_ECO57 3-octaprenyl-4-hydroxybenzoate carboxy-lyase (EC 4.1.1.-) (PolyprenylubiX Z3573p-hydroxybenzoate ECs3195 decarboxylase)Ubiquinone and other terpenoid-quinone biosynthesisCytoplasmic 20,695 Probable aromatic acid decarboxylase DB03247 Yes No 92 P0AG22 RELA_ECO57 GTP pyrophosphokinase (EC 2.7.6.5) ((p)ppGpp synthase) (ATP:GTPrelA 3'-pyrophosphotransferase) Z4099 ECs3644 Purine (ppGpp metabolism synthase I) Cytoplasmic 83,876 Putative GTP pyrophosphokinase DB02836; DB04315 Yes No 93 P0AG42 RIBF_ECO57 Riboflavin biosynthesis protein RibF [Includes: Riboflavin kinase (ECribF 2.7.1.26)Z0029 ECs0028 (Flavokinase);Riboflavin FMN adenylyltransferase metabolism (EC 2.7.7.2) (FAD pyrophosphorylase)Cytoplasmic (FAD synthase)]34,734 Riboflavin kinase/FMN adenylyltransferase DB03247; DB03431; DB04272; DB04345 Yes No 94 P0AG53 RL30_ECO57 50S ribosomal protein L30 rpmD Z4672 ECs4167 Ribosome Cytoplasmic 6,542 Yes Yes 95 P0AG57 RL6_ECO57 50S ribosomal protein L6 rplF Z4675 ECs4170 Ribosome Cytoplasmic 18,904 Yes Yes 96 P0AG88 SECB_ECO57 Protein-export protein SecB secB Z5036 ECs4487 Protein export Cytoplasmic 17,277 Yes No Bacterial secretion system* 97 P0AG91 SECD_ECO57 Protein translocase subunit SecD secD Z0507 ECs0459 Protein export Membrane 66,632 Yes No Bacterial secretion system* 98 P0AG95 SECF_ECO57 Protein translocase subunit SecF secF Z0508 ECs0460 Protein export Membrane 35,382 Yes No Bacterial secretion system* 99 P0AG98 SECE_ECO57 Preprotein translocase subunit SecE secE Z5554 ECs4904 Protein export Membrane 13,643 Yes No Bacterial secretion system* 100 P0AGA1 SECG_ECO57 Protein-export membrane protein SecG (P12) (Preprotein translocasesecG band Z4537 1 subunit) ECs4054 Protein export Membrane 11,365 Yes No Bacterial secretion system* 101 P58194 UBID_ECO57 3-octaprenyl-4-hydroxybenzoate carboxy-lyase (EC 4.1.1.-) (PolyprenylubiD Z5364p-hydroxybenzoate ECs4771 decarboxylase)Ubiquinone and other terpenoid-quinone biosynthesisCytoplasmic 55,648 No No 102 P58209 DAPB_ECO57 Dihydrodipicolinate reductase (DHPR) (EC 1.3.1.26) dapB Z0036 ECs0034 Lysine biosynthesis Cytoplasmic 28,798 Dihydrodipicolinate reductase DB01907; DB03969; DB04267 Yes No 103 P58237 HIS5_ECO57 Imidazole glycerol phosphate synthase subunit HisH (EC 2.4.2.-) (IGPhisH synthase Z3185 ECs2824 glutamine amidotransferaseHistidine metabolism subunit) (IGP synthase subunit HisH)Cytoplasmic (ImGP synthase subunit21,595 HisH) (IGPS subunit HisH) Yes No 104 P58256 ILVC_ECO57 Ketol-acid reductoisomerase (EC 1.1.1.86) (Acetohydroxy-acid isomeroreductase)ilvC Z5285 ECs4708 (Alpha-keto-beta-hydroxylacilValine, leucine and reductoisomerase)isoleucine biosynthesis Cytoplasmic 54,064 Yes No Pantothenate and CoA biosynthesis 105 P58263 THIG_ECO57 Thiazole synthase (EC 2.8.1.10) thiG Z5565 ECs4914 Thiamine metabolism Cytoplasmic 26,865 Yes No 106 P58357 TORR_ECO57 TorCAD operon transcriptional regulatory protein torR torR Z1412 ECs1150 Two-component system* Cytoplasmic 26,269 Yes No 107 P58364 TORD_ECO57 Chaperone protein TorD torD Z1416 ECs1153 Two-component system* Cytoplasmic 22,496 Yes No 108 P58640 PYRF_ECO57 Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) (OMP decarboxylase)pyrF Z2525 (OMPDCase) ECs1854 (OMPdecase)Pyrimidine metabolism Cytoplasmic 26,230 Orotidine 5'-phosphate decarboxylase DB02890; DB03668; DB03685 Yes No 109 P58704 CYNS_ECO57 Cyanate hydratase (Cyanase) (EC 4.2.1.104) (Cyanate hydrolase) (CyanatecynS cnt lyase)Z0436 ECs0393 Nitrogen metabolism* Unknown 17,048 Yes No 110 P58713 PDXA_ECO57 4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262) (4-(phosphohydroxy)-L-threoninepdxA Z0061 ECs0057 Vitamin dehydrogenase) B6 metabolism Cytoplasmic 35,209 4-hydroxythreonine-4-phosphate dehydrogenase ; DB02609 Yes No 111 P60625 RL24_ECO57 50S ribosomal protein L24 rplX Z4679 ECs4174 Ribosome Cytoplasmic 11,316 Yes No 112 P60665 HIS6_ECO57 Imidazole glycerol phosphate synthase subunit HisF (EC 4.1.3.-) (IGPhisF synthase Z3187 ECs2826 cyclase subunit)Histidine (IGP synthase metabolism subunit HisF) (ImGP synthase subunitCytoplasmic HisF) (IGPS subunit28,454 HisF) Yes No 113 P60784 PLSY_ECO57 Glycerol-3-phosphate acyltransferase (G3P acyltransferase) (GPAT)plsY (EC ygiH 2.3.1.15) Z4412 (EC ECs3942 2.3.1.n5)Glycerolipid (Lysophosphatidic metabolism acid synthase) (LPA synthase)Membrane 22,193 Yes No Glycerophospholipid metabolism 114 P60933 UPPP_ECO57 Undecaprenyl-diphosphatase (EC 3.6.1.27) (Bacitracin resistance protein)uppP bacA (Undecaprenyl upk Z4410 ECs3940pyrophosphatePeptidoglycan phosphatase) biosynthesis* Membrane 29,759 Yes No 115 P61717 RISB_ECO57 6,7-dimethyl-8-ribityllumazine synthase (DMRL synthase) (LumazineribH synthase) ribE Z0516 (EC ECs0468 2.5.1.9) (RiboflavinRiboflavin metabolismsynthase beta chain) Cytoplasmic 16,157 6,7-dimethyl-8-ribityllumazine synthase DB04162; DB02214; DB04128; DB04262 Yes No 116 P61951 FLAV_ECO57 Flavodoxin-1 fldA Z0832 ECs0715 Nitrogen metabolism* Cytoplasmic 19,737 Flavodoxin;Flavodoxin-1 DB03247 Yes No 117 P62397 SECM_ECO57 Secretion monitor secM Z0107 ECs0101 Protein export Unknown 18,866 No No Bacterial secretion system* 118 P62616 ISPE_ECO57 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (CMK) (EC 2.7.1.148)ispE Z1979 (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol ECs1713 Terpenoid backbone biosynthesis kinase) Cytoplasmic 30,925 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase DB03687; DB04395 Yes No 119 P62618 ISPF_ECO57 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECDP-synthase)ispF Z4054 (MECPS) ECs3600 (EC 4.6.1.12)Terpenoid backbone biosynthesis Cytoplasmic 16,898 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase;IspD/ispF bifunctionalDB02552; enzymeDB03403; [Includes: DB04555; 2-C-methyl-D-erythritol DB04714; DB07780; 4- DB02212; phosphate DB01859; cytidylyltransferase; DB03687;Yes DB03961;No DB03687; 120 P62622 ISPG_ECO57 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (EC 1.17.7.1)ispG (1-hydroxy-2-methyl-2-(E)-butenyl gcpE Z3778 ECs3377 Terpenoid backbone 4-diphosphate biosynthesis synthase) Cytoplasmic 40,684 Yes No 121 P62625 ISPH_ECO57 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC 1.17.1.2)ispH lytB Z0034 ECs0032 Terpenoid backbone biosynthesis Cytoplasmic 34,775 4-hydroxy-3-methylbut-2-enyl diphosphate reductase DB01785; DB04714 Yes No 122 P63225 GMHA_ECO57 Phosphoheptose isomerase (EC 5.3.1.28) (Sedoheptulose 7-phosphategmhA isomerase) lpcA Z0280 ECs0249Lipopolysaccharide biosynthesis* Cytoplasmic 20,815 Phosphoheptose isomerase DB02470 Yes No 123 P63486 ALLA_ECO57 Ureidoglycolate hydrolase (EC 3.5.3.19) allA Z0659 ECs0566 Purine metabolism Unknown 18,223 Yes Yes 124 P63610 AROC_ECO57 Chorismate synthase (EC 4.2.3.5) (5-enolpyruvylshikimate-3-phosphatearoC Z3592phospholyase) ECs3213 Phenylalanine, tyrosine and tryptophan biosynthesisCytoplasmic 39,151 Chorismate synthase DB03247; DB03350 Yes No 125 P63624 ASNA_ECO57 Aspartate--ammonia ligase (EC 6.3.1.1) (Asparagine synthetase A)asnA Z5245 ECs4686 Alanine, aspartate and glutamate metabolism Cytoplasmic 36,650 Yes No Cyanoamino acid metabolism Nitrogen metabolism* 126 P63633 MURI_ECO57 Glutamate racemase (EC 5.1.1.3) murI Z5528 ECs4898 D-Glutamine and D-glutamate metabolism Cytoplasmic 31,074 Glutamate racemase DB02343 Yes No 127 P64558 YGFM_ECO57 Uncharacterized protein ygfM ygfM Z4219 ECs3753 Selenocompound metabolism Cytoplasmic 28,650 Yes No 128 P65323 LPXD_ECO57 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase (UDP-3-O-(3-OHC14)-GlcNlpxD Z0191 ECs0181 N-acyltransferase)Lipopolysaccharide (EC biosynthesis* 2.3.1.191) Cytoplasmic 36,024 Yes No 129 P65471 MURC_ECO57 UDP-N-acetylmuramate--L-alanine ligase (EC 6.3.2.8) (UDP-N-acetylmuramoyl-L-alaninemurC Z0101 ECs0095 synthetase)D-Glutamine and D-glutamate metabolism Cytoplasmic 53,598 UDP-N-acetylmuramate--L-alanine ligase DB01673; DB03909; DB04395 Yes No Peptidoglycan biosynthesis* 130 P65737 PLSX_ECO57 Phosphate acyltransferase (EC 2.3.1.n2) (Acyl-ACP phosphotransacylase)plsX Z1729 (Acyl-[acyl-carrier-protein]--phosphate ECs1468 Glycerolipid metabolism acyltransferase) (Phosphate-acyl-ACPCytoplasmic acyltransferase)38,224 Yes No Glycerophospholipid metabolism 131 P67026 SYGA_ECO57 Glycine--tRNA ligase alpha subunit (EC 6.1.1.14) (Glycyl-tRNA synthetaseglyQ Z4984 alpha ECs4443 subunit) (GlyRS)Aminoacyl-tRNA biosynthesis Cytoplasmic 34,716 Yes No 132 P67031 SYGB_ECO57 Glycine--tRNA ligase beta subunit (EC 6.1.1.14) (Glycyl-tRNA synthetaseglyS Z4983 beta ECs4442 subunit) (GlyRS)Aminoacyl-tRNA biosynthesis Cytoplasmic 76,813 No No 133 P67676 PRIB_ECO57 Primosomal replication protein n priB Z5810 ECs5177 Homologous recombination Unknown 11,472 Yes No 134 P68681 RS21_ECO57 30S ribosomal protein S21 rpsU Z4418 ECs3948 Ribosome Cytoplasmic 8,500 Yes No 135 P69424 TATC_ECO57 Sec-independent protein translocase protein TatC tatC mttB Z5360 ECs4768 Bacterial secretion system* Membrane 28,876 Yes No 136 P69772 PAD1_ECO57 Probable aromatic acid decarboxylase (EC 4.1.1.-) pad1 Z4047 ECs3593 Ubiquinone and other terpenoid-quinone biosynthesisCytoplasmic 21,470 Probable aromatic acid decarboxylase ; DB03247 Yes Yes 137 P69788 PTGCB_ECO57 PTS system glucose-specific EIICB component (EIICB-Glc) (EII-Glc)ptsG [Includes: Z1740 ECs1479 Glucose permeaseGlycolysis IIC component / Gluconeogenesis (PTS system glucose-specificMembrane EIIC component); Glucose-specific50,677 phosphotransferase enzyme IIB component (EC 2.7.1.69) (PTS system glucose-specific EIIB component)] Yes No Amino sugar and nucleotide sugar metabolism Phosphotransferase system* 138 P69793 PTQA_ECO57 N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIA componentchbA celC (EC Z2766 2.7.1.-) ECs2442 (EIIA-Chb)Phosphotransferase (EIII-Chb) (PTS system* system N,N'-diacetylchitobiose-specificCytoplasmic EIIA component)12,748 Yes No 139 P69799 PTNAB_ECO57 PTS system mannose-specific EIIAB component (EIIAB-Man) [Includes:manX Z2860 Mannose-specific ECs2527 phosphotransferaseFructose and mannose enzyme metabolism IIA component (EC 2.7.1.-)Cytoplasmic (EIII-Man) (PTS system35,048 mannose-specific EIIA component); Mannose-specific phosphotransferase enzyme IIB component (EC 2.7.1.69) (PTS system mannose-specific EIIB component)]Yes No Amino sugar and nucleotide sugar metabolism Phosphotransferase system* 140 P69812 PTFAH_ECO57 Multiphosphoryl transfer protein (MTP) (Phosphotransferase FPr protein)fruB Z3427 (Pseudo-HPr) ECs3061 [Includes:Fructose Phosphocarrier and mannose protein metabolism HPr (Protein H); Fructose-specificCytoplasmic phosphotransferase39,648 enzyme IIA component (EC 2.7.1.-) (PTS system fructose-specific EIIA component)] Yes No Phosphotransferase system* 141 P69827 PTMCB_ECO57 PTS system mannitol-specific cryptic EIICB component (EIICB-Mtl)cmtA (EII-Mtl) Z4277 ECs3808[Includes: MannitolFructose permease and mannose IIC component metabolism (PTS system mannitol-specificMembrane EIIC component);48,971 Mannitol-specific phosphotransferase enzyme IIB component (EC 2.7.1.69) (PTS system mannitol-specific EIIB component)] Yes No Phosphotransferase system* 142 P69830 PTQB_ECO57 N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIB componentchbB celA (EC Z2768 2.7.1.69) ECs2444 (PTSPhosphotransferase system N,N'-diacetylchitobiose-specific system* EIIB component)Cytoplasmic 11,427 N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIB componentDB03544 Yes No 143 P69915 CSRA_ECO57 Carbon storage regulator csrA zfiA Z3998 ECs3553 Two-component system* Unknown 6,856 Yes No 144 Q7A909 Q7A909_ECO57 Putative aldolase ECs5069 Glycolysis / Gluconeogenesis Cytoplasmic 31,120 Tagatose-1,6-bisphosphate aldolase agaY DB03026 Yes No Pentose phosphate pathway Fructose and mannose metabolism Methane metabolism* 145 Q7A978 KATG1_ECO57 Catalase-peroxidase 1 (CP 1) (EC 1.11.1.21) (Peroxidase/catalase 1)katG1 Z5497 ECs4871 Phenylalanine metabolism Cytoplasmic 80,040 Peroxidase/catalase ;Peroxidase/catalase T ; DB03014; DB08638; DB00609; DB00951 Yes No Tryptophan metabolism Methane metabolism* 146 Q7A9V4 Q7A9V4_ECO57 Mannitol-specific PTS system enzyme IIABC components ECs4475 Fructose and mannose metabolism Membrane 68,030 Yes No Phosphotransferase system* 147 Q7A9Z2 Q7A9Z2_ECO57 Dipeptide transport protein ABC transporters Membrane 60,312 Nickel-binding periplasmic protein ;Periplasmic oligopeptide-bindingDB03374; protein DB07365 Yes No Bacterial chemotaxis* 148 Q7AAG8 Q7AAG8_ECO57 Glutamate synthase large subunit ECs4091 Alanine, aspartate and glutamate metabolism Cytoplasmic 166,752 Ferredoxin-dependent glutamate synthase 2 DB02926; DB03247 Yes No Nitrogen metabolism* 149 Q7AAK7 Q7AAK7_ECO57 N-acetylgalactosamine-specific PTS system enzyme IIB componentECs4011 Galactose metabolism Cytoplasmic 18,479 Yes No Phosphotransferase system* 150 Q7AAL3 Q7AAL3_ECO57 Putative uncharacterized protein ECs4002 ECs4002 Glycine, serine and threonine metabolism Cytoplasmic 42,113 Yes No Glycerolipid metabolism Glyoxylate and dicarboxylate metabolism 151 Q7AAL9 Q7AAL9_ECO57 L-serine deaminase ECs3992 Glycine, serine and threonine metabolism Cytoplasmic 48,560 Yes No Cysteine and methionine metabolism 152 Q7ABT1 Q7ABT1_ECO57 Sulfate transport system permease W protein ECs3294 ABC transporters Membrane 16,652 No No 153 Q7ABV7 Q7ABV7_ECO57 Multidrug resistance protein Y ECs3246 Two-component system* Membrane 56,117 Yes No 154 Q7AC15 Q7AC15_ECO57 Isochorismate hydroxymutase 2 ECs3153 Ubiquinone and other terpenoid-quinone biosynthesisCytoplasmic 40,326 Yes No Biosynthesis of siderophore group nonribosomal peptides* 155 Q7AC70 Q7AC70_ECO57 Putative transport system permease protein ECs3071 ABC transporters Membrane 38,120 No No 156 Q7ACR3 Q7ACR3_ECO57 Exonuclease I ECs2813 Mismatch repair Cytoplasmic 54,501 Yes No 157 Q7AD45 Q7AD45_ECO57 L-arabinose-binding periplasmic protein ECs2609 ABC transporters Membrane 35,503 L-arabinose-binding periplasmic protein DB03142; DB03246; DB03485; DB04062 Yes No 158 Q7AD51 Q7AD51_ECO57 Methyl-accepting chemotaxis protein II ECs2596 Two-component system* Membrane 59,926 Methyl-accepting chemotaxis protein II DB02365 Yes No 159 Q7AD93 Q7AD93_ECO57 L-serine deaminase ECs2523 Glycine, serine and threonine metabolism Cytoplasmic 48,937 No No Cysteine and methionine metabolism 160 Q7AD95 Q7AD95_ECO57 p-aminobenzoate synthetase component I ECs2521 Folate biosynthesis Cytoplasmic 50,951 Para-aminobenzoate synthase component 1 DB01942 Yes No 161 Q7ADE7 ASTB_ECO57 N-succinylarginine dihydrolase (EC 3.5.3.23) astB Z2777 ECs2451 Arginine and proline metabolism Cytoplasmic 49,325 N-succinylarginine dihydrolase DB02501; DB03582 No No 162 Q7ADM2 Q7ADM2_ECO57 Sensor histidine protein kinase RstA regulator ECs2315 Two-component system* Membrane 49,363 Osmolarity sensor protein envZ DB04395 Yes No 163 Q7ADN3 Q7ADN3_ECO57 Putative oxidoreductase major subunit ECs2294 Selenocompound metabolism Membrane 90,081 Dimethyl sulfoxide reductase ;Thiosulfate reductase ;Formate dehydrogenaseDB02153; H DB02379; DB08689; DB02345; Yes No 164 Q7AF85 Q7AF85_ECO57 4-amino-4-deoxychorismate lyase ECs1474 Folate biosynthesis Cytoplasmic 29,665 Aminodeoxychorismate lyase DB03579 Yes No 165 Q7AG83 Q7AG83_ECO57 Arginine 3rd transport system periplasmic binding protein ECs0943 ABC transporters Membrane 26,846 Yes No 166 Q7AGM8 Q7AGM8_ECO57 PTS system, N-acetylglucosamine-specific enzyme IIABC ECs0709 Amino sugar and nucleotide sugar metabolism Membrane 68,332 Yes No 167 Q7AGQ1 Q7AGQ1_ECO57 Citrate lyase alpha chain ECs0654 Citrate cycle (TCA cycle) Cytoplasmic 55,117 Yes No Two-component system* 168 Q7AGR4 Q7AGR4_ECO57 Ferric enterobactin (Enterochelin) binding protein periplasmic componentECs0631 ABC transporters Membrane 34,345 Yes No 169 Q7AGY5 Q7AGY5_ECO57 Primosomal replication protein N'' ECs0520 Homologous recombination Cytoplasmic 20,387 No No 170 Q7DB96 Q7DB96_ECO57 Lipid A-core:surface polymer ligase (Putative LPS biosynthesis enzyme)waaL ECs4500 Z5049 Lipopolysaccharide biosynthesis* Membrane 46,099 No No 171 Q7DKV4 Q7DKV4_ECO57 Type 4 prepilin-like proteins leader peptide-processing enzyme (ECetpN 2.1.1.-) ECO57PM12 Bacterial secretion system* Membrane 26,287 No No 172 Q8X2R8 Q8X2R8_ECO57 Replication protein P ECs1190 DNA replication Cytoplasmic 54,054 Yes No 173 Q8X4I9 ALR2_ECO57 Alanine racemase, catabolic (EC 5.1.1.1) dadX dadB Z1953 ECs1685D-Alanine metabolism* Cytoplasmic 38,859 Alanine racemase, catabolic ;Alanine racemase DB03252; DB03801; DB00260; DB01993; DB02142; DB03097; DB03327; DB03579;Yes DB03766;No DB04467 174 Q8X4N9 Q8X4N9_ECO57 Permease of putrescine transport protein (Putrescine transport protein;potI permease) ECs0937 Z1084 ABC transporters Membrane 30,474 No No 175 Q8X4Q2 Q8X4Q2_ECO57 Putative oxidoreductase major subunit (Putative oxidoreductase, majorECs2293 subunit) Z2575 Selenocompound metabolism Membrane 89,528 Dimethyl sulfoxide reductase ;Thiosulfate reductase ;Formate dehydrogenaseDB02153; H DB02379; DB08689; DB02345 Yes No 176 Q8X4R2 GATY_ECO57 D-tagatose-1,6-bisphosphate aldolase subunit GatY (TBPA) (TagBPgatY aldolase) Z3259 (EC ECs2899 4.1.2.40) (D-tagatose-bisphosphateGalactose metabolism aldolase class II) (Tagatose-bisphosphateCytoplasmic aldolase)30,855 DB03026 Yes No 177 Q8X523 Q8X523_ECO57 DNA polymerase III delta subunit (DNA polymerase III, delta subunit)holA ECs0678 Z0787 Purine metabolism Membrane 38,730 Yes No Pyrimidine metabolism DNA replication Mismatch repair Homologous recombination 178 Q8X584 Q8X584_ECO57 Putative ABC transporter permease protein (Putative iron compoundECs1698 ABC transporter, Z1965 permeaseABC protein) transporters Membrane 34,805 Yes No 179 Q8X5C8 Q8X5C8_ECO57 Anthranilate synthase component I ECs1836 Phenylalanine, tyrosine and tryptophan biosynthesisCytoplasmic 57,594 Para-aminobenzoate synthase component 1 DB01942 180 Q8X5I2 Q8X5I2_ECO57 Taurine dioxygenase (Taurine dioxygenase, 2-oxoglutarate-dependent)tauD ECs0422 Z0467 Taurine and hypotaurine metabolism Cytoplasmic 32,379 Alpha-ketoglutarate-dependent taurine dioxygenase ;Putative alkylsulfataseDB01956; DB07518 Yes No 181 Q8X5J1 Q8X5J1_ECO57 Periplasmic ferric iron-binding protein (Putative periplasmic-iron-bindingafuA ECs0415 protein) Z0460 ABC transporters Membrane 37,403 Yes No 182 Q8X5J2 Q8X5J2_ECO57 Putative ferric transport system permease (Putative permease componentafuB ECs0414 of transport Z0459 system forABC ferric transporters iron) Membrane 75,772 Yes No 183 Q8X5K2 Q8X5K2_ECO57 3-methyl-adenine DNA glycosylase I (3-methyladenine DNA glycosylasetag ECs4434 I) Z4974 Base excision repair Unknown 21,151 DNA-3-methyladenine glycosylase 1 DB04104 Yes No 184 Q8X5T4 Q8X5T4_ECO57 Formate-dependent nitrite reductase NrfB (Formate-dependent nitritenrfB reductase; ECs5053 a Z5670penta-haemeNitrogen cytochrome metabolism* c) Membrane 20,960 Yes No 185 Q8X5V2 ALR1_ECO57 Alanine racemase, biosynthetic (EC 5.1.1.1) alr Z5651 ECs5035 D-Alanine metabolism* Cytoplasmic 39,195 Alanine racemase, catabolic ;Alanine racemase DB03252; DB03801; DB00260; DB01993; DB02142; DB03097; DB03327; DB03579;Yes DB03766;No DB03801; DB04467 186 Q8X5V3 DNAB_ECO57 Replicative DNA helicase (EC 3.6.4.12) dnaB Z5650 ECs5034 DNA replication Cytoplasmic 52,406 Yes No 187 Q8X5W4 AROH_ECO57 Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive (EC 2.5.1.54)aroH Z2733 (3-deoxy-D-arabino-heptulosonate ECs2411 Phenylalanine, tyrosine 7-phosphate and tryptophan synthase) biosynthesis(DAHP synthase)Cytoplasmic (Phospho-2-keto-3-deoxyheptonate38,719 Phospho-2-dehydro-3-deoxyheptonate aldolase) aldolase, Phe-sensitive DB01819; DB02726 Yes No 188 Q8X610 META_ECO57 Homoserine O-succinyltransferase (EC 2.3.1.46) (Homoserine O-transsuccinylase)metA Z5599 ECs4931 (HTS) Cysteine and methionine metabolism Cytoplasmic 35,784 Yes No Sulfur metabolism 189 Q8X622 Q8X622_ECO57 Riboflavin synthase alpha chain (Riboflavin synthase, alpha chain)ribE ECs2371 Z2688 Riboflavin metabolism Cytoplasmic 23,435 Riboflavin synthase alpha chain DB00140 Yes No 190 Q8X641 Q8X641_ECO57 Galactose-binding transport protein (Galactose-binding transport protein;mglB ECs3042 receptor forZ3405 galactoseABC taxis) transporters Membrane 35,743 D-galactose-binding periplasmic protein precursor ; D-galactose-bindingDB02379 periplasmic protein Yes No Bacterial chemotaxis* 191 Q8X663 Q8X663_ECO57 PTS system, maltose and glucose-specific II ABC malX ECs2329 Z2626 Glycolysis / Gluconeogenesis Membrane 56,641 Yes No Starch and sucrose metabolism 192 Q8X6A8 Q8X6A8_ECO57 Carbamate kinase yahI ECs0372 Z0412 Purine metabolism Cytoplasmic 34,000 Yes No Arginine and proline metabolism 193 Q8X6J0 YAGS_ECO57 Putative xanthine dehydrogenase YagS FAD-binding subunit (EC 1.17.1.4)yagS Z0351 ECs0315 Purine metabolism Cytoplasmic 33,886 Yes No 194 Q8X6M7 Q8X6M7_ECO57 DNA helicase RecC (DNA helicase, ATP-dependent dsDNA/ssDNArecC exonuclease ECs3679 VZ4139 subunit, ssDNAHomologous endonuclease) recombination Cytoplasmic 128,726 Yes No 195 Q8X6N9 Q8X6N9_ECO57 Arginine 3rd transport system periplasmic binding protein artI ECs0946 Z1093 ABC transporters Membrane 26,934 Yes No 196 Q8X6Q3 Q8X6Q3_ECO57 Putative transport protein ECs0940 Z1087 Ascorbate and aldarate metabolism Membrane 48,531 No No Phosphotransferase system* 197 Q8X6Q9 Q8X6Q9_ECO57 Permease of putrescine transport protein (Putrescine transport protein;potH permease) ECs0936 Z1083 ABC transporters Membrane 35,466 Yes No 198 Q8X6R6 Q8X6R6_ECO57 Cell division membrane protein (Cell division membrane protein FtsX)ftsX ECs4311 Z4836 ABC transporters Membrane 38,543 No No 199 Q8X6S0 Q8X6S0_ECO57 L-serine dehydratase (L-serine dehydratase (Deaminase), L-SD2) sdaB ECs3657 Z4114 Glycine, serine and threonine metabolism Cytoplasmic 48,670 Yes No Cysteine and methionine metabolism 200 Q8X6V6 GSID_ECO57 Glutathione transport system permease protein gsiD gsiD Z1056 ECs0911 ABC transporters Membrane 33,252 No No 201 Q8X6V9 GSIB_ECO57 Glutathione-binding protein gsiB gsiB Z1054 ECs0909 ABC transporters Membrane 56,414 Periplasmic oligopeptide-binding protein;Nickel-binding periplasmicDB07365; protein DB03374 Yes No 202 Q8X6X9 THIC_ECO57 Phosphomethylpyrimidine synthase (EC 4.1.99.17) (HydroxymethylpyrimidinethiC Z5569 ECs4917 phosphate synthase)Thiamine (HMP-P metabolism synthase) (HMP-phosphate synthase)Cytoplasmic (HMPP synthase) (Thiamine70,814 biosynthesis protein ThiC) Yes No 203 Q8X710 Q8X710_ECO57 4-alpha-glucanotransferase (4-alpha-glucanotransferase (Amylomaltase))malQ ECs4258 Z4771 Starch and sucrose metabolism Cytoplasmic 78,539 Yes No 204 Q8X711 MURB_ECO57 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) (UDP-N-acetylmuramatemurB Z5543 ECs4899 dehydrogenase)Amino sugar and nucleotide sugar metabolism Cytoplasmic 37,888 UDP-N-acetylenolpyruvoylglucosamine reductase DB03147; DB07296 Yes No Peptidoglycan biosynthesis* 205 Q8X726 Q8X726_ECO57 Putative amino acid amidohydrolase (Putative hippuricase) ECs4892 Z5522 Phenylalanine metabolism Cytoplasmic 42,189 Yes No 206 Q8X732 ARGC_ECO57 N-acetyl-gamma-glutamyl-phosphate reductase (AGPR) (EC 1.2.1.38)argC (N-acetyl-glutamate Z5516 ECs4887 semialdehydeArginine and dehydrogenase) proline metabolism (NAGSA dehydrogenase)Cytoplasmic 35,860 Yes No 207 Q8X743 CAPP_ECO57 Phosphoenolpyruvate carboxylase (PEPC) (PEPCase) (EC 4.1.1.31)ppc Z5514 ECs4885 Pyruvate metabolism Cytoplasmic 99,107 Phosphoenolpyruvate carboxylase DB04317 Yes No Methane metabolism* 208 Q8X770 Q8X770_ECO57 Response transcriptional regulatory protein (RstB sensor) (ResponserstA transcriptional ECs2314 Z2609 regulatory Two-componentprotein RstB sensor) system* Cytoplasmic 27,030 Yes No 209 Q8X779 Q8X779_ECO57 Primosomal protein N' (Primosomal protein N'(= factor Y)(PutativepriA helicase)) ECs4862 Z5482 Homologous recombination Unknown 81,625 Yes No 210 Q8X7A1 Q8X7A1_ECO57 Fructose-1,6-bisphosphatase glpX ECs4850 Z5470 Glycolysis / Gluconeogenesis Cytoplasmic 35,884 Yes No Pentose phosphate pathway Fructose and mannose metabolism 211 Q8X7B5 TRPA_ECO57 Tryptophan synthase alpha chain (EC 4.2.1.20) trpA Z2551 ECs1832 Glycine, serine and threonine metabolism Cytoplasmic 28,725 Tryptophan synthase alpha chain DB03171; DB04143; DB07732; DB07745; DB07748; DB07773; DB07890; DB07894;Yes DB07925;No DB07951; DB07952; DB07953; DB04272 Phenylalanine, tyrosine and tryptophan biosynthesis 212 Q8X7B6 TRPB_ECO57 Tryptophan synthase beta chain (EC 4.2.1.20) trpB Z2550 ECs1833 Glycine, serine and threonine metabolism Cytoplasmic 42,997 Tryptophan synthase beta chain DB03171; DB04143; DB07732; DB07745; DB07748; DB07773; DB07890; DB07894;Yes DB07925;No DB07951; DB07952; DB07953 Phenylalanine, tyrosine and tryptophan biosynthesis 213 Q8X7B7 TRPC_ECO57 Tryptophan biosynthesis protein TrpCF [Includes: Indole-3-glyceroltrpC phosphate Z2549 ECs1834synthase (IGPS)Phenylalanine, (EC 4.1.1.48); tyrosine N-(5'-phospho-ribosyl)anthranilate and tryptophan biosynthesisCytoplasmic isomerase (PRAI) (EC49,302 5.3.1.24)] Tryptophan biosynthesis protein trpCF DB03543 Yes No 214 Q8X7C2 Q8X7C2_ECO57 Cob(I)alamin adenolsyltransferase btuR ECs1842 Z2540 Porphyrin and chlorophyll metabolism Cytoplasmic 22,027 Yes No 215 Q8X7G5 Q8X7G5_ECO57 Phosphomethylpyrimidine kinase thiD ECs2906 Z3267 Thiamine metabolism Unknown 28,618 Phosphomethylpyrimidine kinase DB02022 Yes No

216 Q8X7N8 Q8X7N8_ECO57 Aminoacyl-histidine dipeptidase (Peptidase D) (Aminoacyl-histidinepepD dipeptidase ECs0264 PepD) Z0298 Glutathione metabolism Cytoplasmic 52,917 Yes No 217 Q8X7X4 CYSD_ECO57 Sulfate adenylyltransferase subunit 2 (EC 2.7.7.4) (ATP-sulfurylasecysD small Z4060 subunit) ECs3606 (Sulfate adenylatePurine transferase)metabolism (SAT) Cytoplasmic 35,188 Yes No Selenocompound metabolism Sulfur metabolism 218 Q8X7Y5 Q8X7Y5_ECO57 DNA polymerase III epsilon subunit (DNA polymerase III, epsilon dnaQsubunit) ECs0211 Z0241 Purine metabolism Cytoplasmic 27,099 DNA polymerase III subunit epsilon DB01643 Yes No Pyrimidine metabolism DNA replication Mismatch repair Homologous recombination 219 Q8X809 Q8X809_ECO57 Peptidoglycan synthetase (Peptidoglycan synthetase; penicillin-bindingmrcA protein ECs4238 1A) Z4750 Peptidoglycan biosynthesis* Membrane 94,491 Penicillin-binding protein 1A ;Penicillin-binding protein 1B ;Penicillin-bindingDB00274; proteinDB00303; 2 ;Penicillin-binding DB00430; DB00438; proteins DB01327; 1A/1B DB01328; ;Penicillin-binding DB01329; protein DB01331; 1C ;Penicillin-bindingYes DB01332;No DB01333; protein DB01414; 1b DB01415; DB01598; DB04570; DB01150; DB00415; DB00456; DB00485; DB00493; DB00567; DB00607; DB00713; DB00739; DB01000; DB01140; DB01163; DB01603; DB03313; DB08375; DB08795; DB08401; DB04147; DB00229; DB00267; DB00301; DB00417; DB00447; DB00833; DB00948; DB01060; DB01061; DB01066; DB01112; DB01139; DB01147; DB01602; DB01604; DB01605; DB04133; DB00319; DB08508 220 Q8X824 AROB_ECO57 3-dehydroquinate synthase (EC 4.2.3.4) aroB Z4742 ECs4231 Phenylalanine, tyrosine and tryptophan biosynthesisCytoplasmic 38,884 3-dehydroquinate synthase DB01907; DB02592 Yes No 221 Q8X825 BIOB_ECO57 Biotin synthase (EC 2.8.1.6) bioB Z0994 ECs0853 Biotin metabolism Cytoplasmic 38,638 Biotin synthase DB03754; DB03775 Yes No 222 Q8X883 TUSD_ECO57 Sulfurtransferase TusD (EC 2.8.1.-) (tRNA 2-thiouridine synthesizingtusD protein Z4703 D) ECs4196 Sulfur relay system Cytoplasmic 13,679 Yes No 223 Q8X884 TUSC_ECO57 Protein TusC (tRNA 2-thiouridine synthesizing protein C) tusC Z4702 ECs4195 Sulfur relay system Unknown 13,145 Yes No 224 Q8X885 TUSB_ECO57 Protein TusB (tRNA 2-thiouridine synthesizing protein B) tusB Z4701 ECs4194 Sulfur relay system Unknown 10,662 No No 225 Q8X8A1 RHAD_ECO57 Rhamnulose-1-phosphate aldolase (EC 4.1.2.19) rhaD Z5446 ECs4829 Pentose and glucuronate interconversions Cytoplasmic 30,117 Rhamnulose-1-phosphate aldolase DB03026 Yes No Fructose and mannose metabolism 226 Q8X8D9 Q8X8D9_ECO57 Spermidine/putrescine periplasmic transport protein potD ECs1499 Z1762 ABC transporters Membrane 38,791 Spermidine/putrescine-binding periplasmic protein precursor;Putrescine-bindingDB03566; DB01917 periplasmic protein Yes No 227 Q8X8E2 Q8X8E2_ECO57 Putative kinase ycfW ECs1496 Z1759 ABC transporters Membrane 45,291 No No 228 Q8X8F9 AROE_ECO57 Shikimate dehydrogenase (EC 1.1.1.25) aroE Z4652 ECs4147 Phenylalanine, tyrosine and tryptophan biosynthesisCytoplasmic 29,294 Shikimate dehydrogenase ; DB03461; DB04447; DB02363 Yes No 229 Q8X8L5 METE_ECO57 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferasemetE Z5351(EC 2.1.1.14) ECs4759 (Cobalamin-independentCysteine and methionine methionine metabolism synthase) (MethionineCytoplasmic synthase, vitamin-B1284,723 independent5-methyltetrahydropteroyltriglutamate--homocysteine isozyme) methyltransferaseDB04375; DB04422; DB04481 Yes No Selenocompound metabolism 230 Q8X8N8 PYRC_ECO57 Dihydroorotase (DHOase) (EC 3.5.2.3) pyrC Z1699 ECs1440 Pyrimidine metabolism Cytoplasmic 38,844 Dihydroorotase DB02129; DB02262; DB03801; DB04252 Yes No 231 Q8X8P5 Q8X8P5_ECO57 DNA-dependent ATPase I and helicase II uvrD ECs4743 Z5330 Nucleotide excision repair Cytoplasmic 82,004 Yes No Mismatch repair 232 Q8X8T3 HISX_ECO57 Histidinol dehydrogenase (HDH) (EC 1.1.1.23) hisD Z3182 ECs2821 Histidine metabolism Cytoplasmic 46,074 Histidinol dehydrogenase DB01907; DB03811; DB04077; DB04447 Yes No 233 Q8X8T4 HIS1_ECO57 ATP phosphoribosyltransferase (ATP-PRT) (ATP-PRTase) (EC 2.4.2.17)hisG Z3181 ECs2820 Histidine metabolism Cytoplasmic 33,352 ATP phosphoribosyltransferase DB01661 Yes No 234 Q8X8V9 METQ_ECO57 D-methionine-binding lipoprotein metQ metQ Z0209 ECs0199 ABC transporters Membrane 29,417 Yes No 235 Q8X8X5 DPO3A_ECO57 DNA polymerase III subunit alpha (EC 2.7.7.7) dnaE Z0196 ECs0186 Purine metabolism Cytoplasmic 129,900 Yes No Pyrimidine metabolism DNA replication Mismatch repair Homologous recombination 236 Q8X8X7 LPXB_ECO57 Lipid-A-disaccharide synthase (EC 2.4.1.182) lpxB Z0194 ECs0184 Lipopolysaccharide biosynthesis* Cytoplasmic 42,398 Yes No 237 Q8X8X8 LPXA_ECO57 Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferaselpxA Z0193 (UDP-N-acetylglucosamine ECs0183 Lipopolysaccharide acyltransferase) biosynthesis* (EC 2.3.1.129) Cytoplasmic 28,050 Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferaseDB01694; DB08558 Yes No 238 Q8X8Y1 DXR_ECO57 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXP reductoisomerase)dxr Z0184 (EC ECs0175 1.1.1.267) (1-deoxyxylulose-5-phosphateTerpenoid backbone biosynthesis reductoisomerase) (2-C-methyl-D-erythritolMembrane 4-phosphate43,361 1-deoxy-D-xylulosesynthase) 5-phosphate reductoisomerase DB02496; DB02948; DB03649; DB04272 Yes No 239 Q8X8Y6 GLND_ECO57 [Protein-PII] uridylyltransferase (PII uridylyl-transferase) (EC 2.7.7.59)glnD Z0177(UTase) ECs0169 (Uridylyl-removingTwo-component enzyme) system* Membrane 102,422 Yes No 240 Q8X8Y7 DAPD_ECO57 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferasedapD (EC 2.3.1.117)Z0176 ECs0168 (TetrahydrodipicolinateLysine biosynthesis N-succinyltransferase) (THDP succinyltransferase)Cytoplasmic (THP succinyltransferase)29,878 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (Tetrahydropicolinate succinylase) N-succinyltransferase DB01856; DB01992; DB03134; DB03699; DB03905 Yes Yes 241 Q8X8Z5 Q8X8Z5_ECO57 Ferrichrome-iron transport protein fhuB (Hydroxamate-dependent ironfhuB uptake, ECs0157 cytoplasmic Z0164 membraneABC transporters component) Membrane 70,348 Yes No 242 Q8X900 GSH1_ECO57 Glutamate--cysteine ligase (EC 6.3.2.2) (Gamma-ECS) (GCS) (Gamma-glutamylcysteinegshA Z3989 ECs3550 synthetase)Glutathione metabolism Cytoplasmic 58,255 Glutamate--cysteine ligase; DB03431; DB04464 No No 243 Q8X903 Q8X903_ECO57 Peptidoglycan synthetase MrcB (Peptidoglycan synthetase; penicillin-bindingmrcB ECs0153 protein Z0160 1B) Peptidoglycan biosynthesis* Membrane 94,265 Penicillin-binding protein 1B ;Penicillin-binding proteins 1A/1B ;Penicillin-bindingDB00274; DB00303; protein DB00430; 1A ;Penicillin-binding DB00438; DB01327; protein 2 DB01328; ;Penicillin-binding DB01329; protein DB01331; 1C ;Penicillin-bindingYes DB01332;No DB01414; protein DB01415; 1b ; DB01598; DB04570; DB08401; DB00229; DB00267; DB00301; DB00417; DB00447; DB00456; DB00713; DB00833; DB00948; DB01000; DB01060; DB01061; DB01066; DB01112; DB01139; DB01147; DB01602; DB01604; DB01605; DB04133; DB01150; DB00415; DB00485; DB00493; DB00567; DB00607; DB00739; DB01140; DB01163; DB01603; DB03313; DB08375; DB08795; DB04147; DB01333; DB00319; DB08508 244 Q8X911 Q8X911_ECO57 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase)folK ECs0146 Z0153 Folate biosynthesis Cytoplasmic 17,984 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinaseDB02119; DB02596; DB03197; DB03431; DB04047; DB04158; DB04610; DB02278 Yes No 245 Q8X929 PANB_ECO57 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11) panB(Ketopantoate Z0145 ECs0138 hydroxymethyltransferase)Pantothenate and (KPHMT) CoA biosynthesis Cytoplasmic 28,310 3-methyl-2-oxobutanoate hydroxymethyltransferase DB03795; DB04074 Yes No 246 Q8X930 PANC_ECO57 Pantothenate synthetase (PS) (EC 6.3.2.1) (Pantoate--beta-alanine ligase)panC Z0144 (Pantoate-activating ECs0137 enzyme)beta-Alanine metabolism Cytoplasmic 31,568 Pantoate--beta-alanine ligase DB01930; DB02596; DB02694; DB03107 Yes No Pantothenate and CoA biosynthesis 247 Q8X935 Q8X935_ECO57 Putative PTS enzyme II B component yadI ECs0133 Z0140 Ascorbate and aldarate metabolism Cytoplasmic 16,568 Yes No Phosphotransferase system* 248 Q8X938 Q8X938_ECO57 Carbonic anhydrase (EC 4.2.1.1) yadF ECs0130 Z0137 Nitrogen metabolism* Cytoplasmic 25,155 Yes No 249 Q8X946 Q8X946_ECO57 Glucose dehydrogenase gcd ECs0128 Z0134 Pentose phosphate pathway Membrane 86,777 Quinohemoprotein alcohol dehydrogenase ADH IIB ;ethanol dehydrogenaseDB03014; type-1 DB03205; DB03051; DB03205; DB03317; DB03679 Yes No 250 Q8X963 NADA_ECO57 Quinolinate synthase A (EC 2.5.1.72) nadA Z0919 ECs0778 Nicotinate and nicotinamide metabolism Cytoplasmic 38,281 No No 251 Q8X979 Q8X979_ECO57 Cytochrome d terminal oxidase polypeptide subunit I (CytochromecydA d terminal ECs0768 oxidase, Z0900 polypeptideOxidative subunit phosphorylation I) Membrane 58,336 No No Two-component system* 252 Q8X9A0 Q8X9A0_ECO57 Putative transport system permease protein yhdY ECs4143 Z4631 ABC transporters Membrane 41,636 No No 253 Q8X9A1 Q8X9A1_ECO57 Putative cob(I)alamin adenosyltransferase (Putative corrinoid:ATP ECs0756adenosyltransferase) Z0886 Porphyrin and chlorophyll metabolism Cytoplasmic 22,372 Yes No 254 Q8X9E2 Q8X9E2_ECO57 Phospho-2-dehydro-3-deoxyheptonate aldolase (EC 2.5.1.54) (3-deoxy-D-arabino-heptulosonatearoF ECs3464 Z3893 Phenylalanine, 7-phosphate tyrosinesynthase) and (DAHP tryptophan synthase) biosynthesis (Phospho-2-keto-3-deoxyheptonateCytoplasmic 38,760 aldolase)Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive DB01819; DB02726 Yes No 255 Q8X9F8 ATKA_ECO57 Potassium-transporting ATPase A chain (EC 3.6.3.12) (ATP phosphohydrolasekdpA Z0845 [potassium-transporting] ECs0726 Two-component A chain) system* (Potassium-binding and translocatingMembrane subunit A) (Potassium-translocating59,082 ATPase A chain) No No 256 Q8X9G2 Q8X9G2_ECO57 Regulator of kdp operon (Transcriptional effector) (TranscriptionalkdpE regulator ECs0722 of kdp Z0841 operon) Two-component system* Cytoplasmic 25,279 Yes No 257 Q8X9G9 NANE_ECO57 Putative N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9)nanE (ManNAc-6-P Z4581 ECs4096 epimerase)Amino sugar and nucleotide sugar metabolism Unknown 24,159 Yes No 258 Q8X9I1 MTGA_ECO57 Monofunctional biosynthetic peptidoglycan transglycosylase (MonofunctionalmtgA Z4571 TGase) ECs4087 (EC 2.4.2.-)Peptidoglycan biosynthesis* Membrane 27,269 Yes No 259 Q8X9I8 Q8X9I8_ECO57 Phosphotransferase system enzyme IIA (Phosphotransferase systemptsN enzyme ECs4083 IIA, regulatesZ4567 N metabolism)Phosphotransferase system* Cytoplasmic 17,959 Yes No 260 Q8X9I9 Q8X9I9_ECO57 RNA polymerase sigma-54 factor rpoN ECs4081 Z4565 Two-component system* Cytoplasmic 53,994 Yes No 261 Q8X9J9 MURA_ECO57 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) murA(Enoylpyruvate Z4552 ECs4068 transferase)Amino (UDP-N-acetylglucosamine sugar and nucleotide sugar enolpyruvyl metabolism transferase)Cytoplasmic (EPT) 44,848 UDP-N-acetylglucosamine 1-carboxyvinyltransferase DB03397; DB00828; DB01879; DB02435; DB02995; DB03089; DB04174; DB04474 Yes No Peptidoglycan biosynthesis* 262 Q8X9K8 Q8X9K8_ECO57 D-alanyl-D-alanine carboxypeptidase (D-alanyl-D-alanine carboxypeptidase,dacB ECs4061 fraction Z4544 B; penicillin-bindingPeptidoglycan protein biosynthesis* 4) Membrane 51,826 Penicillin-binding protein 4 ;D-alanyl-D-alanine carboxypeptidase DB00303; DB00417; DB00760; DB01328; DB01329; DB01331; DB04570; DB04742 Yes No 263 Q8X9L1 Q8X9L1_ECO57 7,8-dihydropteroate synthase folP ECs4056 Z4539 Folate biosynthesis Cytoplasmic 32,417 Dihydropteroate synthase ;Dihydropteroate synthase 1 ;DihydropteroateDB00259; synthase DB00263; 2 DB00576; DB00634; DB01015; DB01298; DB01581; DB01582;Yes DB06729;No DB03592; DB03705; DB04047; DB04196;DB00250;DB00891; 264 Q8X9W8 Q8X9W8_ECO57 Putative resistance protein ECs2052 Z2271 Phosphonate and phosphinate metabolism* Cytoplasmic 19,249 Yes No 265 Q8X9Y1 Q8X9Y1_ECO57 Cryptic nitrate reductase 2 beta subunit (Cryptic nitrate reductase 2,narY beta ECs2070 subunit) Z2245 Nitrogen metabolism* Membrane 58,545 Respiratory nitrate reductase 1 beta chain DB04464; DB07349 Yes No 266 Q8X9Y2 Q8X9Y2_ECO57 Cryptic nitrate reductase 2 alpha subunit (Cryptic nitrate reductase narZ2, alpha ECs2071 subunit) Z2244 Nitrogen metabolism* Membrane 140,037 Respiratory nitrate reductase 1 alpha chain DB04464; DB07349 Yes No 267 Q8X9Y8 MURG_ECO57 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenolmurG Z0100 ECs0094 N-acetylglucosaminePeptidoglycan biosynthesis* transferase (EC 2.4.1.227) (Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAcMembrane 37,801 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) GlcNAc transferase) pyrophosphoryl-undecaprenolDB02196 N-acetylglucosamine transferase Yes No 268 Q8X9Y9 MURD_ECO57 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) (D-glutamicmurD Z0098 acid-adding ECs0092 enzyme)D-Glutamine (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate and D-glutamate metabolism Unknown synthetase) 47,002 UDP-N-acetylmuramoylalanine--D-glutamate ligase DB01673; DB02314; DB03431; DB03801; DB08105; DB08106; DB08107; DB08108;Yes DB08112No Peptidoglycan biosynthesis* 269 Q8X9Z1 Q8X9Z1_ECO57 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (ECmurF 6.3.2.10) ECs0090 Z0096 Lysine biosynthesis Cytoplasmic 47,463 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase DB06970 Yes No Peptidoglycan biosynthesis* 270 Q8X9Z2 MURE_ECO57 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelatemurE ligase Z0095 (EC ECs0089 6.3.2.13) (Meso-A2pm-addingLysine biosynthesis enzyme) (Meso-diaminopimelate-addingCytoplasmic enzyme) (UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate53,390 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase) (UDP-MurNAc-tripeptide ligaseDB02314; synthetase) DB03590; (UDP-N-acetylmuramyl-tripeptide DB03801 synthetase) Yes No Peptidoglycan biosynthesis* 271 Q8X9Z5 Q8X9Z5_ECO57 Acetolactate synthase III small subunit (Acetolactate synthase III, valineilvH ECs0082 sensitive, Z0088 small subunit)Valine, leucine and isoleucine biosynthesis Cytoplasmic 18,061 Yes No Butanoate metabolism Pantothenate and CoA biosynthesis C5-Branched dibasic acid metabolism* 272 Q8XA05 Q8XA05_ECO57 Putative transport system permease protein yabK ECs0071 Z0076 ABC transporters Membrane 59,395 Yes No 273 Q8XA39 ACPS_ECO57 Holo-[acyl-carrier-protein] synthase (Holo-ACP synthase) (EC 2.7.8.7)acpS (4'-phosphopantetheinyldpj Z3844 ECs3429 Pantothenate transferase AcpS)and CoA biosynthesis Cytoplasmic 14,124 Yes No 274 Q8XA48 LSPA_ECO57 Lipoprotein signal peptidase (EC 3.4.23.36) (Prolipoprotein signal lspApeptidase) Z0031 (Signal ECs0030 peptidaseProtein II) (SPase export II) Membrane 18,144 No No 275 Q8XA73 HCAF_ECO57 3-phenylpropionate/cinnamic acid dioxygenase subunit beta (EC 1.14.12.19)hcaF Z3810 (Digoxigenin ECs3405 subunitPhenylalanine beta) metabolism Unknown 20,526 Yes No 276 Q8XA84 Q8XA84_ECO57 Aspartokinase I, homoserine dehydrogenase I (Aspartokinase I-homoserinethrA ECs0002 dehydrogenase Z0002 I) Glycine, serine and threonine metabolism Cytoplasmic 89,079 Yes No Cysteine and methionine metabolism Lysine biosynthesis 277 Q8XAB8 Q8XAB8_ECO57 Galactosamine-specific PTS system enzyme IIB component (PTS system,agaB ECs4018 cytoplasmic, Z4492 N-acetylgalactosamine-specificGalactose metabolism IIB component 1 (EIIB-AGA))Cytoplasmic 17,608 Yes Yes Phosphotransferase system* 278 Q8XAF1 TDCD_ECO57 Propionate kinase (EC 2.7.2.15) tdcD Z4467 ECs3995 Propanoate metabolism Cytoplasmic 43,399 Yes No 279 Q8XAF2 Q8XAF2_ECO57 Probable formate acetyltransferase 3 (Putative formate acetyltransferasetdcE ECs39943) Z4466 Pyruvate metabolism Cytoplasmic 85,935 Formate acetyltransferase 1 ;Glycerol dehydratase DB01992; DB03278; DB03940; DB01839 Yes No Propanoate metabolism Butanoate metabolism 280 Q8XAG0 URE1_ECO57 Urease subunit alpha (EC 3.5.1.5) (Urea amidohydrolase subunit alpha)ureC1 Z1145 ECs1324; ureC2Purine Z1584 metabolism Cytoplasmic 60,626 Urease alpha subunit DB00551; DB05265; DB02899 Yes No 281 Q8XAG1 URE2_ECO57 Urease subunit beta (EC 3.5.1.5) (Urea amidohydrolase subunit beta)ureB1 Z1144 ECs1323; ureB2Purine Z1583 metabolism Cytoplasmic 11,761 Urease subunit beta DB02899 Yes No Arginine and proline metabolism 282 Q8XAG2 URE3_ECO57 Urease subunit gamma (EC 3.5.1.5) (Urea amidohydrolase subunit ureA1gamma) Z1143 ECs1322; ureA2Purine Z1582 metabolism Cytoplasmic 11,085 Urease subunit gamma DB02899 Yes No Arginine and proline metabolism 283 Q8XAG6 Q8XAG6_ECO57 Putative diacylglycerol kinase ECs1316 Z1139 Z1578 Glycerolipid metabolism Membrane 12,886 No No Glycerophospholipid metabolism 284 Q8XAP1 CYAA_ECO57 Adenylate cyclase (EC 4.6.1.1) (ATP pyrophosphate-lyase) (AdenylylcyaA cyclase) Z5322 ECs4736 Purine metabolism Cytoplasmic 97,559 No No 285 Q8XAP5 Q8XAP5_ECO57 Uroporphyrinogen III synthase hemD ECs4734 Z5318 Porphyrin and chlorophyll metabolism Unknown 27,811 Yes No 286 Q8XAT5 GPPA_ECO57 Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC 3.6.1.40)gppA Z5289 (Guanosine ECs4712 pentaphosphatePurine metabolismphosphohydrolase) (pppGpp-5'-phosphohydrolase)Cytoplasmic 54,871 Yes No 287 Q8XAV1 ILVD_ECO57 Dihydroxy-acid dehydratase (DAD) (EC 4.2.1.9) ilvD Z5282 ECs4705 Valine, leucine and isoleucine biosynthesis Cytoplasmic 65,576 No No Pantothenate and CoA biosynthesis 288 Q8XB03 Q8XB03_ECO57 High-affinity phosphate-specific transport system; periplasmic phosphate-bindingpstS ECs4664 Z5219 protein (Phosphate-bindingABC transporters periplasmic protein PstS) Membrane 37,050 Phosphate-binding protein pstS precursor DB02799; DB02831 Yes No Two-component system* 289 Q8XB09 Q8XB09_ECO57 Catabolic regulation response regulator creB ECs5356 Z6001 Two-component system* Cytoplasmic 26,211 Yes No 290 Q8XB47 Q8XB47_ECO57 DNA polymerase III psi subunit (DNA polymerase III, psi subunit)holD ECs5330 Z5973 Purine metabolism Unknown 15,207 Yes No Pyrimidine metabolism DNA replication Mismatch repair Homologous recombination 291 Q8XB55 DNAT_ECO57 Primosomal protein 1 (Primosomal protein I) dnaT Z5962 ECs5322 Homologous recombination Unknown 19,499 No No 292 Q8XBA3 Q8XBA3_ECO57 Flagellar biosynthesis, component of motor switch and energizing, fliNenabling ECs2685 rotation Z3036 and determiningBacterial its chemotaxis*direction (Flagellar motor switch protein UnknownFliN) 14,811 Yes No Flagellar assembly* 293 Q8XBA8 Q8XBA8_ECO57 Flagellar fliJ protein fliJ ECs2681 Z3032 Flagellar assembly* Cytoplasmic 17,325 No No 294 Q8XBC8 Q8XBC8_ECO57 Putative transport system permease protein (Putative transport systemyecS permease ECs2656 protein Z3006 (FormerABC yecC)) transporters Membrane 24,831 No No 295 Q8XBG3 Q8XBG3_ECO57 Ethanolamine utilization protein EutI (Ethanolamine utilization; homologeutI ECs3320 of Salmonella Z3714 acetyl/butyrylPyruvate P metabolism transferase) Cytoplasmic 36,014 Phosphate acetyltransferase DB02897 Yes No 296 Q8XBJ6 Q8XBJ6_ECO57 Sulfate transport system permease T protein (Sulfate, thiosulfate transportcysU ECs3295 system permeaseZ3689 T protein)ABC transporters Membrane 30,309 Yes No 297 Q8XBL1 Q8XBL1_ECO57 Glucose-specific PTS system IIA component (PTS system, glucose-specificcrr ECs3289 IIA Z3683component) Glycolysis / Gluconeogenesis Cytoplasmic 18,266 Yes No Starch and sucrose metabolism Amino sugar and nucleotide sugar metabolism Phosphotransferase system*

298 Q8XBL2 Q8XBL2_ECO57 Putative kinase ygiG ECs3941 Z4411 Folate biosynthesis Cytoplasmic 13,750 Yes No 299 Q8XBL3 Q8XBL3_ECO57 Phosphoenolpyruvate-protein phosphotransferase (EC 2.7.3.9) (PhosphotransferaseptsI ECs3288 Z3682 system, enzymePhosphotransferase I) system* Cytoplasmic 63,534 Phosphoenolpyruvate-protein phosphotransferase DB08357 Yes No 300 Q8XBQ7 Q8XBQ7_ECO57 Putative iron compound permease protein of ABC transporter familyECs3915 (Putative Z4384 permease of ferrichromeABC transporters ABC transporter) Membrane 33,807 Yes No 301 Q8XBS3 QSEB_ECO57 Transcriptional regulatory protein qseB qseB Z4377 ECs3907 Two-component system* Cytoplasmic 24,746 Yes No 302 Q8XBV5 Q8XBV5_ECO57 Ferric enterobactin (Enterochelin) transport fepD ECs0629 Z0732 ABC transporters Membrane 33,857 Yes No 303 Q8XBV6 Q8XBV6_ECO57 Ferric enterobactin transport protein fepG ECs0628 Z0731 ABC transporters Membrane 34,934 Yes No 304 Q8XBZ3 DNAA_ECO57 Chromosomal replication initiator protein DnaA dnaA Z5193 ECs4637 Two-component system* Cytoplasmic 52,541 Chromosomal replication initiator protein dnaA DB03431 Yes No 305 Q8XC30 Q8XC30_ECO57 Probable third cytochrome oxidase subunit II (Probable third cytochromeappB ECs1135 oxidase, Z1396subunit II) Oxidative phosphorylation Membrane 42,441 No No Two-component system* 306 Q8XC31 Q8XC31_ECO57 Probable third cytochrome oxidase subunit I (Probable third cytochromeappC ECs1134oxidase, subunitZ1395 I) Oxidative phosphorylation Membrane 58,021 No No Two-component system* 307 Q8XC50 NLPA_ECO57 Lipoprotein 28 nlpA Z5147 ECs4595 ABC transporters Membrane 29,423 Yes No 308 Q8XCA4 Q8XCA4_ECO57 Putative uncharacterized protein ECs5239 (Putative uncharacterizedyjgQ protein ECs5239 yjgQ) Z5874 ABC transporters Membrane 39,750 No No 309 Q8XCB1 Q8XCB1_ECO57 DNA polymerase III chi subunit (DNA polymerase III, chi subunit)holC ECs5236 Z5871 Purine metabolism Cytoplasmic 16,574 Yes No Pyrimidine metabolism DNA replication Mismatch repair Homologous recombination 310 Q8XCE2 Q8XCE2_ECO57 Anaerobic ribonucleoside-triphosphate reductase nrdD ECs5215 Z5848 Pyrimidine metabolism Cytoplasmic 80,037 Anaerobic ribonucleoside-triphosphate reductase DB02181; DB02452; DB03222; DB03258 Yes No 311 Q8XCE9 Q8XCE9_ECO57 Proton conductor component of motor (Proton conductor componentmotA of motor; ECs2600 no effectZ2944 on switching)Two-component system* Membrane 31,997 No No Bacterial chemotaxis* Flagellar assembly* 312 Q8XCF5 Q8XCF5_ECO57 Sensory transducer kinase CheA (Sensory transducer kinase betweencheA chemo-signal ECs2598 Z2942 receptors andTwo-component CheB and CheY) system* Cytoplasmic 71,412 Chemotaxis protein cheA DB02524; DB03431; DB03909; DB04395 Yes No Bacterial chemotaxis* 313 Q8XCF8 Q8XCF8_ECO57 Response regulator for chemotaxis (Response regulator for chemotaxis;cheR proteinECs2594 glutamate Z2938 methyltransferase)Two-component system* Cytoplasmic 32,839 Chemotaxis protein methyltransferase DB01752 Yes No Bacterial chemotaxis* 314 Q8XCJ1 Q8XCJ1_ECO57 Putative adhesin yebL ECs2567 Z2909 ABC transporters Membrane 36,030 Yes No 315 Q8XCJ3 Q8XCJ3_ECO57 Heat shock protein MsbB (Suppressor of htrB, heat shock protein) msbB ECs2565 Z2907 Lipopolysaccharide biosynthesis* Membrane 37,376 No No 316 Q8XCU1 LPXH_ECO57 UDP-2,3-diacylglucosamine hydrolase (EC 3.6.1.54) (UDP-2,3-diacylglucosaminelpxH Z0679 ECs0586 diphosphatase)Lipopolysaccharide biosynthesis* Cytoplasmic 26,952 Yes No 317 Q8XCU8 Q8XCU8_ECO57 Phosphate acetyltransferase (EC 2.3.1.8) (Phosphotransacetylase) pta ECs3181 Z3559 Taurine and hypotaurine metabolism Cytoplasmic 77,158 Phosphate acetyltransferase DB02897 Yes No Pyruvate metabolism Propanoate metabolism Methane metabolism* 318 Q8XCV4 Q8XCV4_ECO57 Phosphoribosylaminoimidazole carboxylase (PhosphoribosylaminoimidazolepurK ECs0584 carboxylase Z0677 = AIRPurine carboxylase, metabolism CO(2)-fixing subunit) Membrane 39,572 Phosphoribosylaminoimidazole carboxylase ATPase subunit DB03431 Yes No 319 Q8XCV5 ARCC_ECO57 Carbamate kinase (EC 2.7.2.2) arcC Z0676 ECs0583 Purine metabolism Cytoplasmic 31,731 Yes No Arginine and proline metabolism Nitrogen metabolism* 320 Q8XCW0 Q8XCW0_ECO57 Glycerate kinase (Putative uncharacterized protein ybbZ) ybbZ ECs0576 Z0669 Glycine, serine and threonine metabolism Cytoplasmic 38,847 Yes No Glycerolipid metabolism Glyoxylate and dicarboxylate metabolism 321 Q8XD78 Q8XD78_ECO57 Carbamate kinase yqeA ECs3747 Z4213 Purine metabolism Cytoplasmic 33,113 Yes No Arginine and proline metabolism 322 Q8XD82 TUSE_ECO57 Sulfurtransferase TusE (EC 2.8.1.-) (tRNA 2-thiouridine synthesizingtusE protein Z1321 E) ECs1053 Sulfur relay system Cytoplasmic 12,410 Yes No 323 Q8XDB7 Q8XDB7_ECO57 Glucosyltransferase I (Glucosyltransferase I; lipopolysaccharide corerfaG biosynthesis) ECs4506 Z5055 Lipopolysaccharide biosynthesis* Cytoplasmic 42,509 Yes No 324 Q8XDC6 Q8XDC6_ECO57 Nitrate reductase 1 beta subunit (Nitrate reductase 1, beta subunit) narH ECs1730 Z2002 Nitrogen metabolism* Membrane 58,080 Respiratory nitrate reductase 1 beta chain DB04464; DB07349 Yes No Two-component system* 325 Q8XDC8 Q8XDC8_ECO57 Nitrate reductase 1 alpha subunit (Nitrate reductase 1, alpha subunit)narG ECs1729 Z2001 Nitrogen metabolism* Membrane 140,458 Respiratory nitrate reductase 1 alpha chain DB04464; DB07349 Yes No Two-component system* 326 Q8XDD3 Q8XDD3_ECO57 Heptosyl transferase I (Heptosyl transferase I; lipopolysaccharide corerfaC biosynthesis) ECs4499 Z5048 Lipopolysaccharide biosynthesis* Cytoplasmic 36,854 Yes No 327 Q8XDD5 Q8XDD5_ECO57 ADP-heptose--lps heptosyltransferase II (ADP-heptose--lps heptosyltransferaserfaF ECs4498 II; Z5047 lipopolysaccharideLipopolysaccharide core biosynthesis) biosynthesis* Cytoplasmic 39,027 Yes No 328 Q8XDE7 KDSA_ECO57 2-dehydro-3-deoxyphosphooctonate aldolase (EC 2.5.1.55) (3-deoxy-D-manno-octulosonickdsA Z1986 ECs1720 acidLipopolysaccharide 8-phosphate synthase) biosynthesis* (KDO-8-phosphate synthase)Cytoplasmic (KDO 8-P synthase)30,861 (KDOPS) 2-dehydro-3-deoxyphosphooctonate(Phospho-2-dehydro-3-deoxyoctonate aldolase aldolase) DB01819; DB02433; DB03113; DB03936; DB01709; DB02053; DB02992; DB03248; YesDB03745;No DB03937 329 Q8XDE9 GPMI_ECO57 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (BPG-independentgpmI Z5039 ECs4490 PGAM) (Phosphoglyceromutase)Glycolysis / Gluconeogenesis (iPGM) (EC 5.4.2.1) Cytoplasmic 56,110 2,3-bisphosphoglycerate-independent phosphoglycerate mutase DB01709; DB04510 Yes No Glycine, serine and threonine metabolism Methane metabolism* 330 Q8XDF1 Q8XDF1_ECO57 Outer membrane protein 1a (Outer membrane protein 1a (Ia;b;F)) ompF ECs1012 Z1276 Two-component system* Membrane 39,361 Outer membrane protein F ; Outer membrane protein C ; Outer membraneDB04233; porin DB07084;DB02771;DB02415 C Yes No 331 Q8XDH0 LPXK_ECO57 Tetraacyldisaccharide 4'-kinase (EC 2.7.1.130) (Lipid A 4'-kinase) lpxK Z1261 ECs0998 Lipopolysaccharide biosynthesis* Unknown 35,563 No No 332 Q8XDJ5 ULAA_ECO57 Ascorbate-specific permease IIC component ulaA (Ascorbate-specificulaA PTS Z5802 system ECs5169 EIIC component)Ascorbate and aldarate metabolism Membrane 50,754 No No Phosphotransferase system* 333 Q8XDU4 Q8XDU4_ECO57 2-component regulatory system regulatory protein BasR (TranscriptionalbasR ECs5095 regulatory Z5715 protein 2-componentTwo-component regulatory system* system member) Cytoplasmic 25,001 Yes No 334 Q8XDX8 MEND_ECO57 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate menDsynthase Z3524 (SEPHCHC ECs3152 synthase)Ubiquinone (EC 2.2.1.9) and other (Menaquinone terpenoid-quinone biosynthesis biosynthesis proteinMembrane MenD) 61,292 Yes No 335 Q8XDZ9 NADE_ECO57 NH(3)-dependent NAD(+) synthetase (EC 6.3.1.5) nadE Z2770 ECs2446 Nicotinate and nicotinamide metabolism Cytoplasmic 30,684 NH(3)-dependent NAD(+) synthetase DB01907; DB02937; DB04099; DB04160; DB02212; DB02596 Yes No 336 Q8XE07 RHMD_ECO57 L-rhamnonate dehydratase (RhamD) (EC 4.2.1.90) rhmD Z3505 ECs3135 Fructose and mannose metabolism Cytoplasmic 44,737 Yes No 337 Q8XE13 GLPB_ECO57 Anaerobic glycerol-3-phosphate dehydrogenase subunit B (AnaerobicglpB G-3-P Z3500 dehydrogenase ECs3127 subunitGlycerophospholipid B) (Anaerobic G3Pdhasemetabolism B) (EC 1.1.5.3) Membrane 45,400 Yes No 338 Q8XE41 OMPC_ECO57 Outer membrane protein C (Outer membrane protein 1B) (Porin OmpC)ompC Z3473 ECs3104 Two-component system* Membrane 40,508 Outer membrane porin C ; Outer membrane protein F DB02415; DB04233; DB02771; DB07084 Yes No 339 Q8XE48 Q8XE48_ECO57 Ferredoxin-type protein (Ferredoxin-type protein: electron transfer)napG ECs3094 Z3462 Nitrogen metabolism* Cytoplasmic 24,953 Yes No 340 Q8XE56 Q8XE56_ECO57 Ferredoxin-type protein (Ferredoxin-type protein: electron transfer)napH ECs3093 Z3461 Nitrogen metabolism* Membrane 31,860 Yes No 341 Q8XE66 Q8XE66_ECO57 Nitrate/nitrite response regulator (Sensor NarQ) (Nitrate/nitrite responsenarP ECs3082 regulator Z3450 NarP) Two-component system* Cytoplasmic 23,616 Yes No 342 Q8XE69 RL25_ECO57 50S ribosomal protein L25 rplY Z3444 ECs3077 Ribosome Cytoplasmic 10,675 Yes No 343 Q8XE86 Q8XE86_ECO57 Phosphatidylglycerophosphatase pgpA ECs0471 Z0520 Glycerophospholipid metabolism Membrane 19,331 Yes No 344 Q8XE87 THIL_ECO57 Thiamine-monophosphate kinase (TMP kinase) (Thiamine-phosphatethiL kinase) Z0519 (EC ECs0470 2.7.4.16) Thiamine metabolism Cytoplasmic 35,041 Yes No 345 Q8XE88 Q8XE88_ECO57 Bifunctional pyrimidine deaminase/reductase in pathway of riboflavinribD synthesis ECs0467 Z0515 Riboflavin metabolism Cytoplasmic 40,364 Yes No 346 Q8XE91 Q8XE91_ECO57 Fructose-specific PTS transport system protein (PTS system, fructose-specificfruA ECs3059 transport Z3425 protein)Fructose and mannose metabolism Membrane 57,461 Yes No Phosphotransferase system* 347 Q8XE99 Q8XE99_ECO57 Positive and negative sensor protein for pho regulon (Positive and negativephoR ECs0450 sensor Z0498protein for phoTwo-component regulon PhoR) system* Membrane 49,677 Yes No 348 Q8XEB4 Q8XEB4_ECO57 Formate acetyltransferase 1 pflB ECs0986 Z1248 Pyruvate metabolism Cytoplasmic 85,350 Formate acetyltransferase 1 ;Glycerol dehydratase DB01992; DB03278; DB03940; DB01839 Yes No Propanoate metabolism Butanoate metabolism 349 Q9S5G3 HIS2_ECO57 Histidine biosynthesis bifunctional protein HisIE [Includes: Phosphoribosyl-AMPhisI hisIE Z3188 cyclohydrolase ECs2827 Histidine (PRA-CH) metabolism (EC 3.5.4.19); Phosphoribosyl-ATP Cytoplasmicpyrophosphatase (PRA-PH)22,841 (EC 3.6.1.31)] No No 350 Q9S5G4 HIS4_ECO57 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]hisA imidazole-4-carboxamide Z3186 ECs2825 Histidine isomerase metabolism (EC 5.3.1.16) (Phosphoribosylformimino-5-aminoimidazoleCytoplasmic carboxamide26,031 ribotide isomerase) Yes No

* represents targets from unique pathways List of 120 novel target proteins from common and unique pathways.

No UniProt ID Entry Name Protein Names Gene Names Associated metabolic pathways 1 P0A4D1 RS6_ECO57 30S ribosomal protein S6 rpsF Z5809 ECs5176 Ribosome 2 P0A6A5 ACKA_ECO57 Acetate kinase (EC 2.7.2.1) (Acetokinase) ackA ack Z3558 ECs3180 Taurine and hypotaurine metabolism Pyruvate metabolism Propanoate metabolism Methane metabolism* 3 P0A6K2 DAPF_ECO57 Diaminopimelate epimerase (DAP epimerase) (EC 5.1.1.7) dapF Z5326 ECs4739 Lysine biosynthesis 4 P0A6K8 DEOB_ECO57 Phosphopentomutase (EC 5.4.2.7) (Phosphodeoxyribomutase) deoB drm thyR Z5985 ECs5342 Pentose phosphate pathway Purine metabolism 5 P0A6X2 HEM1_ECO57 Glutamyl-tRNA reductase (GluTR) (EC 1.2.1.70) hemA Z1981 ECs1715 Porphyrin and chlorophyll metabolism 6 P0A6X5 HFQ_ECO57 Protein hfq (HF-1) (Host factor-I protein) (HF-I) hfq Z5779 ECs5148 RNA degradation 7 P0A740 MOAC_ECO57 Molybdenum cofactor biosynthesis protein C moaC chlA3 Z1002 ECs0861 Folate biosynthesis Sulfur relay system 8 P0A778 RPPH_ECO57 RNA pyrophosphohydrolase (EC 3.6.1.-) ((Di)nucleoside polyphosphaterppH nudHhydrolase) Z4147 ECs3687 RNA degradation 9 P0A7F1 PYRH_ECO57 Uridylate kinase (UK) (EC 2.7.4.22) (Uridine monophosphate kinase)pyrH (UMP Z0182 kinase) ECs0173 (UMPK) Pyrimidine metabolism 10 P0A7H2 RECF_ECO57 DNA replication and repair protein RecF recF uvrF Z5191 ECs4635 Homologous recombination 11 P0A7L2 RL1_ECO57 50S ribosomal protein L1 rplA Z5557 ECs4907 Ribosome 12 P0A7M4 RL28_ECO57 50S ribosomal protein L28 rpmB Z5061 ECs4512 Ribosome 13 P0A7M8 RL29_ECO57 50S ribosomal protein L29 rpmC Z4683 ECs4177 Ribosome 14 P0A7N0 RL31_ECO57 50S ribosomal protein L31 rpmE Z5484 ECs4863 Ribosome 15 P0A7Q2 RL35_ECO57 50S ribosomal protein L35 rpmI Z2746 ECs2424 Ribosome 16 P0A7U9 RS20_ECO57 30S ribosomal protein S20 rpsT Z0027 ECs0026 Ribosome 17 P0A802 RPOZ_ECO57 DNA-directed RNA polymerase subunit omega (RNAP omega subunit)rpoZ (ECZ5075 2.7.7.6) ECs4524 (RNA polymerasePurine omega metabolism subunit) (Transcriptase subunit omega) Pyrimidine metabolism RNA polymerase 18 P0A811 RUVA_ECO57 Holliday junction ATP-dependent DNA helicase RuvA (EC 3.6.4.12)ruvA Z2913 ECs2571 Homologous recombination 19 P0A816 RUVC_ECO57 Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4) (HollidayruvC Z2915 junction ECs2573 nuclease RuvC) (HollidayHomologous junction recombination resolvase RuvC) 20 P0A892 TUSA_ECO57 Sulfurtransferase TusA (EC 2.8.1.-) (tRNA 2-thiouridine synthesizingtusA protein Z4844 A) ECs4319 Sulfur relay system 21 P0A966 CHEW_ECO57 Chemotaxis protein CheW cheW Z2941 ECs2597 Two-component system* Bacterial chemotaxis* 22 P0A9Q3 ARCA_ECO57 Aerobic respiration control protein ArcA arcA Z6004 ECs5359 Two-component system* 23 P0AA06 PTHP_ECO57 Phosphocarrier protein HPr (EC 2.7.11.-) (Histidine-containing protein)ptsH Z3681 ECs3287 Phosphotransferase system* 24 P0AA18 OMPR_ECO57 Transcriptional regulatory protein OmpR ompR Z4760 ECs4247 Two-component system* 25 P0ABS6 PRIM_ECO57 DNA primase (EC 2.7.7.-) dnaG Z4419 ECs3949 DNA replication 26 P0AD00 CUSR_ECO57 Transcriptional regulatory protein CusR cusR Z0709 ECs0609 Two-component system* 27 P0AEE9 DMA_ECO57 DNA adenine methylase (EC 2.1.1.72) (DNA adenine methyltransferase)dam Z4740 (Deoxyadenosyl-methyltransferase) ECs4229 Mismatch repair 28 P0AEY4 MAZG_ECO57 Nucleoside triphosphate pyrophosphohydrolase (NTP-PPase) (EC 3.6.1.8)mazG Z4096 ECs3641 Purine metabolism Pyrimidine metabolism 29 P0AF30 NARL_ECO57 Nitrate/nitrite response regulator protein NarL narL Z1996 ECs1726 Two-component system* 30 P0AFJ6 PHOB_ECO57 Phosphate regulon transcriptional regulatory protein phoB phoB Z0497 ECs0449 Two-component system* 31 P0AFL8 PPX_ECO57 Exopolyphosphatase (ExopolyPase) (EC 3.6.1.11) (Metaphosphatase)ppx Z3765 ECs3364 Purine metabolism 32 P0AG53 RL30_ECO57 50S ribosomal protein L30 rpmD Z4672 ECs4167 Ribosome 33 P0AG57 RL6_ECO57 50S ribosomal protein L6 rplF Z4675 ECs4170 Ribosome 34 P0AG88 SECB_ECO57 Protein-export protein SecB secB Z5036 ECs4487 Protein export Bacterial secretion system* 35 P58194 UBID_ECO57 3-octaprenyl-4-hydroxybenzoate carboxy-lyase (EC 4.1.1.-) (PolyprenylubiD Z5364p-hydroxybenzoate ECs4771 decarboxylase)Ubiquinone and other terpenoid-quinone biosynthesis 36 P58237 HIS5_ECO57 Imidazole glycerol phosphate synthase subunit HisH (EC 2.4.2.-) (IGPhisH synthase Z3185 ECs2824 glutamine amidotransferaseHistidine subunit) metabolism (IGP synthase subunit HisH) (ImGP synthase subunit HisH) (IGPS subunit HisH) 37 P58263 THIG_ECO57 Thiazole synthase (EC 2.8.1.10) thiG Z5565 ECs4914 Thiamine metabolism 38 P58357 TORR_ECO57 TorCAD operon transcriptional regulatory protein torR torR Z1412 ECs1150 Two-component system* 39 P58364 TORD_ECO57 Chaperone protein TorD torD Z1416 ECs1153 Two-component system* 40 P60625 RL24_ECO57 50S ribosomal protein L24 rplX Z4679 ECs4174 Ribosome 41 P60665 HIS6_ECO57 Imidazole glycerol phosphate synthase subunit HisF (EC 4.1.3.-) (IGPhisF synthase Z3187 ECs2826 cyclase subunit) (IGP Histidinesynthase subunitmetabolism HisF) (ImGP synthase subunit HisF) (IGPS subunit HisF) 42 P62622 ISPG_ECO57 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (EC 1.17.7.1)ispG (1-hydroxy-2-methyl-2-(E)-butenyl gcpE Z3778 ECs3377 Terpenoid 4-diphosphate backbone synthase) biosynthesis 43 P63624 ASNA_ECO57 Aspartate--ammonia ligase (EC 6.3.1.1) (Asparagine synthetase A)asnA Z5245 ECs4686 Alanine, aspartate and glutamate metabolism Cyanoamino acid metabolism Nitrogen metabolism* 44 P63633 MURI_ECO57 Glutamate racemase (EC 5.1.1.3) murI Z5528 ECs4898 D-Glutamine and D-glutamate metabolism 45 P64558 YGFM_ECO57 Uncharacterized protein ygfM ygfM Z4219 ECs3753 Selenocompound metabolism 46 P65323 LPXD_ECO57 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase (UDP-3-O-(3-OHC14)-GlcNlpxD Z0191 ECs0181 N-acyltransferase)Lipopolysaccharide (EC 2.3.1.191) biosynthesis* 47 P65737 PLSX_ECO57 Phosphate acyltransferase (EC 2.3.1.n2) (Acyl-ACP phosphotransacylase)plsX Z1729 (Acyl-[acyl-carrier-protein]--phosphate ECs1468 Glycerolipid acyltransferase)metabolism (Phosphate-acyl-ACP acyltransferase) Glycerophospholipid metabolism 48 P67026 SYGA_ECO57 Glycine--tRNA ligase alpha subunit (EC 6.1.1.14) (Glycyl-tRNA synthetaseglyQ Z4984 alpha ECs4443 subunit) (GlyRS) Aminoacyl-tRNA biosynthesis 49 P67031 SYGB_ECO57 Glycine--tRNA ligase beta subunit (EC 6.1.1.14) (Glycyl-tRNA synthetaseglyS Z4983 beta ECs4442 subunit) (GlyRS) Aminoacyl-tRNA biosynthesis 50 P68681 RS21_ECO57 30S ribosomal protein S21 rpsU Z4418 ECs3948 Ribosome 51 P69793 PTQA_ECO57 N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIA componentchbA celC (EC Z2766 2.7.1.-) ECs2442 (EIIA-Chb) (EIII-Chb)Phosphotransferase (PTS system system* N,N'-diacetylchitobiose-specific EIIA component) 52 P69799 PTNAB_ECO57 PTS system mannose-specific EIIAB component (EIIAB-Man) [Includes:manX Z2860 Mannose-specific ECs2527 phosphotransferaseFructose and enzyme mannose IIA metabolismcomponent (EC 2.7.1.-) (EIII-Man) (PTS system mannose-specific EIIA component); Mannose-specific phosphotransferase enzyme IIB component (EC 2.7.1.69) (PTS system mannose-specific EIIB component)] Amino sugar and nucleotide sugar metabolism Phosphotransferase system* 53 P69812 PTFAH_ECO57 Multiphosphoryl transfer protein (MTP) (Phosphotransferase FPr protein)fruB Z3427 (Pseudo-HPr) ECs3061 [Includes: PhosphocarrierFructose and proteinmannose HPr metabolism (Protein H); Fructose-specific phosphotransferase enzyme IIA component (EC 2.7.1.-) (PTS system fructose-specific EIIA component)] Phosphotransferase system* 54 Q7AAK7 Q7AAK7_ECO57 N-acetylgalactosamine-specific PTS system enzyme IIB componentECs4011 Galactose metabolism Phosphotransferase system* 55 Q7AAL3 Q7AAL3_ECO57 Putative uncharacterized protein ECs4002 ECs4002 Glycine, serine and threonine metabolism Glycerolipid metabolism Glyoxylate and dicarboxylate metabolism 56 Q7AAL9 Q7AAL9_ECO57 L-serine deaminase ECs3992 Glycine, serine and threonine metabolism Cysteine and methionine metabolism 57 Q7AC15 Q7AC15_ECO57 Isochorismate hydroxymutase 2 ECs3153 Ubiquinone and other terpenoid-quinone biosynthesis Biosynthesis of siderophore group nonribosomal peptides* 58 Q7ACR3 Q7ACR3_ECO57 Exonuclease I ECs2813 Mismatch repair 59 Q7AD93 Q7AD93_ECO57 L-serine deaminase ECs2523 Glycine, serine and threonine metabolism Cysteine and methionine metabolism 60 Q7AGQ1 Q7AGQ1_ECO57 Citrate lyase alpha chain ECs0654 Citrate cycle (TCA cycle) Two-component system* 61 Q7AGY5 Q7AGY5_ECO57 Primosomal replication protein N'' ECs0520 Homologous recombination 62 Q7DKV4 Q7DKV4_ECO57 Type 4 prepilin-like proteins leader peptide-processing enzyme (ECetpN 2.1.1.-) ECO57PM12 Bacterial secretion system* 63 Q8X2R8 Q8X2R8_ECO57 Replication protein P ECs1190 DNA replication 64 Q8X5C8 Q8X5C8_ECO57 Anthranilate synthase component I ECs1836 Phenylalanine, tyrosine and tryptophan biosynthesis 65 Q8X610 META_ECO57 Homoserine O-succinyltransferase (EC 2.3.1.46) (Homoserine O-transsuccinylase)metA Z5599 ECs4931 (HTS) Cysteine and methionine metabolism Sulfur metabolism 66 Q8X6A8 Q8X6A8_ECO57 Carbamate kinase yahI ECs0372 Z0412 Purine metabolism Arginine and proline metabolism 67 Q8X6J0 YAGS_ECO57 Putative xanthine dehydrogenase YagS FAD-binding subunit (EC 1.17.1.4)yagS Z0351 ECs0315 Purine metabolism 68 Q8X6M7 Q8X6M7_ECO57 DNA helicase RecC (DNA helicase, ATP-dependent dsDNA/ssDNArecC exonuclease ECs3679 VZ4139 subunit, ssDNA endonuclease)Homologous recombination 69 Q8X6S0 Q8X6S0_ECO57 L-serine dehydratase (L-serine dehydratase (Deaminase), L-SD2) sdaB ECs3657 Z4114 Glycine, serine and threonine metabolism Cysteine and methionine metabolism 70 Q8X6X9 THIC_ECO57 Phosphomethylpyrimidine synthase (EC 4.1.99.17) (HydroxymethylpyrimidinethiC Z5569 ECs4917 phosphate synthase) (HMP-PThiamine synthase) metabolism (HMP-phosphate synthase) (HMPP synthase) (Thiamine biosynthesis protein ThiC) 71 Q8X710 Q8X710_ECO57 4-alpha-glucanotransferase (4-alpha-glucanotransferase (Amylomaltase))malQ ECs4258 Z4771 Starch and sucrose metabolism 72 Q8X726 Q8X726_ECO57 Putative amino acid amidohydrolase (Putative hippuricase) ECs4892 Z5522 Phenylalanine metabolism 73 Q8X732 ARGC_ECO57 N-acetyl-gamma-glutamyl-phosphate reductase (AGPR) (EC 1.2.1.38)argC (N-acetyl-glutamate Z5516 ECs4887 semialdehydeArginine dehydrogenase) and proline (NAGSAmetabolism dehydrogenase) 74 Q8X770 Q8X770_ECO57 Response transcriptional regulatory protein (RstB sensor) (ResponserstA transcriptional ECs2314 Z2609 regulatory proteinTwo-component RstB sensor) system* 75 Q8X7A1 Q8X7A1_ECO57 Fructose-1,6-bisphosphatase glpX ECs4850 Z5470 Glycolysis / Gluconeogenesis Pentose phosphate pathway Fructose and mannose metabolism 76 Q8X7C2 Q8X7C2_ECO57 Cob(I)alamin adenolsyltransferase btuR ECs1842 Z2540 Porphyrin and chlorophyll metabolism

77 Q8X7N8 Q8X7N8_ECO57 Aminoacyl-histidine dipeptidase (Peptidase D) (Aminoacyl-histidinepepD dipeptidase ECs0264 PepD) Z0298 Glutathione metabolism 78 Q8X7X4 CYSD_ECO57 Sulfate adenylyltransferase subunit 2 (EC 2.7.7.4) (ATP-sulfurylasecysD small Z4060 subunit) ECs3606 (Sulfate adenylate transferase)Purine metabolism (SAT) Selenocompound metabolism Sulfur metabolism 79 Q8X883 TUSD_ECO57 Sulfurtransferase TusD (EC 2.8.1.-) (tRNA 2-thiouridine synthesizingtusD protein Z4703 D) ECs4196 Sulfur relay system 80 Q8X8P5 Q8X8P5_ECO57 DNA-dependent ATPase I and helicase II uvrD ECs4743 Z5330 Nucleotide excision repair Mismatch repair 81 Q8X8X5 DPO3A_ECO57 DNA polymerase III subunit alpha (EC 2.7.7.7) dnaE Z0196 ECs0186 Purine metabolism Pyrimidine metabolism DNA replication Mismatch repair Homologous recombination 82 Q8X8X7 LPXB_ECO57 Lipid-A-disaccharide synthase (EC 2.4.1.182) lpxB Z0194 ECs0184 Lipopolysaccharide biosynthesis* 83 Q8X935 Q8X935_ECO57 Putative PTS enzyme II B component yadI ECs0133 Z0140 Ascorbate and aldarate metabolism Phosphotransferase system* 84 Q8X938 Q8X938_ECO57 Carbonic anhydrase (EC 4.2.1.1) yadF ECs0130 Z0137 Nitrogen metabolism* 85 Q8X963 NADA_ECO57 Quinolinate synthase A (EC 2.5.1.72) nadA Z0919 ECs0778 Nicotinate and nicotinamide metabolism 86 Q8X9A1 Q8X9A1_ECO57 Putative cob(I)alamin adenosyltransferase (Putative corrinoid:ATP ECs0756adenosyltransferase) Z0886 Porphyrin and chlorophyll metabolism 87 Q8X9G2 Q8X9G2_ECO57 Regulator of kdp operon (Transcriptional effector) (TranscriptionalkdpE regulator ECs0722 of kdp Z0841 operon) Two-component system* 88 Q8X9I8 Q8X9I8_ECO57 Phosphotransferase system enzyme IIA (Phosphotransferase systemptsN enzyme ECs4083 IIA, regulatesZ4567 N metabolism)Phosphotransferase system* 89 Q8X9I9 Q8X9I9_ECO57 RNA polymerase sigma-54 factor rpoN ECs4081 Z4565 Two-component system* 90 Q8X9W8 Q8X9W8_ECO57 Putative resistance protein ECs2052 Z2271 Phosphonate and phosphinate metabolism* 91 Q8X9Z1 Q8X9Z1_ECO57 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (ECmurF 6.3.2.10) ECs0090 Z0096 Lysine biosynthesis Peptidoglycan biosynthesis* 92 Q8X9Z5 Q8X9Z5_ECO57 Acetolactate synthase III small subunit (Acetolactate synthase III, valineilvH ECs0082 sensitive, Z0088 small subunit) Valine, leucine and isoleucine biosynthesis Butanoate metabolism Pantothenate and CoA biosynthesis C5-Branched dibasic acid metabolism* 93 Q8XA84 Q8XA84_ECO57 Aspartokinase I, homoserine dehydrogenase I (Aspartokinase I-homoserinethrA ECs0002 dehydrogenase Z0002 I) Glycine, serine and threonine metabolism Cysteine and methionine metabolism Lysine biosynthesis 94 Q8XAB8 Q8XAB8_ECO57 Galactosamine-specific PTS system enzyme IIB component (PTS system,agaB ECs4018 cytoplasmic, Z4492 N-acetylgalactosamine-specificGalactose metabolism IIB component 1 (EIIB-AGA)) Phosphotransferase system* 95 Q8XAF1 TDCD_ECO57 Propionate kinase (EC 2.7.2.15) tdcD Z4467 ECs3995 Propanoate metabolism 96 Q8XAT5 GPPA_ECO57 Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC 3.6.1.40)gppA Z5289 (Guanosine ECs4712 pentaphosphate Purinephosphohydrolase) metabolism (pppGpp-5'-phosphohydrolase) 97 Q8XAV1 ILVD_ECO57 Dihydroxy-acid dehydratase (DAD) (EC 4.2.1.9) ilvD Z5282 ECs4705 Valine, leucine and isoleucine biosynthesis Pantothenate and CoA biosynthesis 98 Q8XB09 Q8XB09_ECO57 Catabolic regulation response regulator creB ECs5356 Z6001 Two-component system* 99 Q8XBA8 Q8XBA8_ECO57 Flagellar fliJ protein fliJ ECs2681 Z3032 Flagellar assembly* 100 Q8XBL1 Q8XBL1_ECO57 Glucose-specific PTS system IIA component (PTS system, glucose-specificcrr ECs3289 IIA Z3683component) Glycolysis / Gluconeogenesis Starch and sucrose metabolism Amino sugar and nucleotide sugar metabolism Phosphotransferase system* 101 Q8XBS3 QSEB_ECO57 Transcriptional regulatory protein qseB qseB Z4377 ECs3907 Two-component system* 102 Q8XCB1 Q8XCB1_ECO57 DNA polymerase III chi subunit (DNA polymerase III, chi subunit)holC ECs5236 Z5871 Purine metabolism Pyrimidine metabolism DNA replication Mismatch repair Homologous recombination 103 Q8XCF5 Q8XCF5_ECO57 Sensory transducer kinase CheA (Sensory transducer kinase betweencheA chemo-signal ECs2598 Z2942 receptors and CheBTwo-component and CheY) system* Bacterial chemotaxis* 104 Q8XCU1 LPXH_ECO57 UDP-2,3-diacylglucosamine hydrolase (EC 3.6.1.54) (UDP-2,3-diacylglucosaminelpxH Z0679 ECs0586 diphosphatase) Lipopolysaccharide biosynthesis* 105 Q8XCV5 ARCC_ECO57 Carbamate kinase (EC 2.7.2.2) arcC Z0676 ECs0583 Purine metabolism Arginine and proline metabolism Nitrogen metabolism* 106 Q8XCW0 Q8XCW0_ECO57 Glycerate kinase (Putative uncharacterized protein ybbZ) ybbZ ECs0576 Z0669 Glycine, serine and threonine metabolism Glycerolipid metabolism Glyoxylate and dicarboxylate metabolism 107 Q8XD78 Q8XD78_ECO57 Carbamate kinase yqeA ECs3747 Z4213 Purine metabolism Arginine and proline metabolism 108 Q8XD82 TUSE_ECO57 Sulfurtransferase TusE (EC 2.8.1.-) (tRNA 2-thiouridine synthesizingtusE protein Z1321 E) ECs1053 Sulfur relay system 109 Q8XDB7 Q8XDB7_ECO57 Glucosyltransferase I (Glucosyltransferase I; lipopolysaccharide corerfaG biosynthesis) ECs4506 Z5055 Lipopolysaccharide biosynthesis* 110 Q8XDD3 Q8XDD3_ECO57 Heptosyl transferase I (Heptosyl transferase I; lipopolysaccharide corerfaC biosynthesis) ECs4499 Z5048 Lipopolysaccharide biosynthesis* 111 Q8XDD5 Q8XDD5_ECO57 ADP-heptose--lps heptosyltransferase II (ADP-heptose--lps heptosyltransferaserfaF ECs4498 II; Z5047 lipopolysaccharideLipopolysaccharide core biosynthesis) biosynthesis* 112 Q8XDU4 Q8XDU4_ECO57 2-component regulatory system regulatory protein BasR (TranscriptionalbasR ECs5095 regulatory Z5715 protein 2-componentTwo-component regulatory system system* member) 113 Q8XE07 RHMD_ECO57 L-rhamnonate dehydratase (RhamD) (EC 4.2.1.90) rhmD Z3505 ECs3135 Fructose and mannose metabolism 114 Q8XE48 Q8XE48_ECO57 Ferredoxin-type protein (Ferredoxin-type protein: electron transfer)napG ECs3094 Z3462 Nitrogen metabolism* 115 Q8XE66 Q8XE66_ECO57 Nitrate/nitrite response regulator (Sensor NarQ) (Nitrate/nitrite responsenarP ECs3082 regulator Z3450 NarP) Two-component system* 116 Q8XE69 RL25_ECO57 50S ribosomal protein L25 rplY Z3444 ECs3077 Ribosome 117 Q8XE87 THIL_ECO57 Thiamine-monophosphate kinase (TMP kinase) (Thiamine-phosphatethiL kinase) Z0519 (EC ECs0470 2.7.4.16) Thiamine metabolism 118 Q8XE88 Q8XE88_ECO57 Bifunctional pyrimidine deaminase/reductase in pathway of riboflavinribD synthesis ECs0467 Z0515 Riboflavin metabolism 119 Q9S5G3 HIS2_ECO57 Histidine biosynthesis bifunctional protein HisIE [Includes: Phosphoribosyl-AMPhisI hisIE Z3188 cyclohydrolase ECs2827 (PRA-CH)Histidine (EC metabolism 3.5.4.19); Phosphoribosyl-ATP pyrophosphatase (PRA-PH) (EC 3.6.1.31)] 120 Q9S5G4 HIS4_ECO57 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]hisA imidazole-4-carboxamide Z3186 ECs2825 isomeraseHistidine (EC metabolism5.3.1.16) (Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase)

* represents targets from unique pathways Novel drug targets involved in different metabolic pathways and other cellular activities

1.#Amino#acid#metabolism#(phenylalanine,#tyrosine#and#tryptophan#biosynthesis,#cysteine#and#methionine#metabolism,#and#lysine#biosynthesis):

Serial'no. KEGG'orthology'number'(ko) Gene Protein'name Pathway

1.1 K00926 arcC Carbamate'kinase'(EC'2.7.2.2) PATH:ece00330 1.2 K00145 argC PATH:ecs00330 NKacetylKgammaKglutamylKphosphate'reductase'(AGPR)'(EC'1.2.1.38)'(NKacetylK glutamate'semialdehyde'dehydrogenase)'(NAGSA'dehydrogenase)

1.3 K01914 asnA AspartateKKammonia'ligase'(EC'6.3.1.1)'(Asparagine'synthetase'A) PATH:ecs00250 1.4 K01778 dapF Diaminopimelate'epimerase'(DAP'epimerase)'(EC'5.1.1.7) PATH:ecs00300 1.5 K11755 hisI'hisIE PATH:ecs00340 Histidine'biosynthesis'bifunctional'protein'HisIE'[Includes:'PhosphoribosylKAMP' cyclohydrolase'(PRAKCH)'(EC'3.5.4.19);'PhosphoribosylKATP'pyrophosphatase'(PRAK PH)'(EC'3.6.1.31)] 1.6 K01814 hisA 1K(5Kphosphoribosyl)K5K[(5Kphosphoribosylamino)methylideneamino]'imidazoleK4K PATH:ecs00340 carboxamide'isomerase'(EC'5.3.1.16)'(PhosphoribosylformiminoK5K 1.7 K02501 hisH Imidazole'glycerol'phosphate'synthase'subunit'HisH'(EC'2.4.2.K)'(IGP'synthase' PATH:ecs00340 glutamine'amidotransferase'subunit)'(IGP'synthase'subunit'HisH)'(ImGP 1.8 K02500' hisF Imidazole'glycerol'phosphate'synthase'subunit'HisF'(EC'4.1.3.K)'(IGP'synthase' PATH:ecs00340 cyclase'subunit)'(IGP'synthase'subunit'HisF)'(ImGP'synthase'subunit'HisF)'(IGPS' subunit'HisF) 1.9 K01687 ilvD DihydroxyKacid'dehydratase'(DAD)'(EC'4.2.1.9) PATH:ecs00290 1.10 K00651 metA Homoserine'OKsuccinyltransferase'(EC'2.3.1.46)'(Homoserine'OKtranssuccinylase)' PATH:ecs00270 (HTS) 1.11 K00865' ybbZ Glycerate'kinase'(Putative'uncharacterized'protein'ybbZ) PATH:ece00260 1.12 K01752 PATH:ecs00260 LKserine'deaminase PATH:ecs00270 1.13 K01657' Anthranilate'synthase'component'I PATH:ecs00400 1.14 K00865 Putative'uncharacterized'protein'ECs4002 PATH:ecs00260 1.15 K01752' PATH:ecs00260 LKserine'deaminase PATH:ecs00270 1.16 K12524 thrA PATH:ecs00260

Aspartokinase'I,'homoserine'dehydrogenase'I'(Aspartokinase'IKhomoserine' dehydrogenase'I)

PATH:ecs00270 PATH:ecs00300 1.17 K01752' sdaB PATH:ece00260 LKserine'dehydratase'(LKserine'dehydratase'(Deaminase),'LKSD2)

1.18 K01653' ilvH Acetolactate'synthase'III'small'subunit'(Acetolactate'synthase'III,'valine'sensitive,' PATH:ece00290 small'subunit) 1.19 K00926' yahI Carbamate'kinase PATH:ece00330 1.20 K01451' Putative'amino'acid'amidohydrolase'(Putative'hippuricase) PATH:ece00360 1.21 K00926' yqeA Carbamate'kinase PATH:ece00330 1.22 K01929' murF UDPKNKacetylmuramoylKtripeptideKKDKalanylKDKalanine'ligase'(EC'6.3.2.10) PATH:ece00300

2.#Carbohydrate#metabolism#(amino#sugar#and#nucleotide#sugar#metabolism,#and#fructose#and#mannose#metabolism)

Serial#no. KEGG#orthology#number# Gene Pathway Protein#name (ko) 2.1 K00925 ackA'ack PATH:ecs00620 Acetate'kinase'(EC'2.7.2.1)'(Acetokinase) PATH:ecs00640 2.2 K01839' deoB'drm'thyR Phosphopentomutase'(EC'5.4.2.7)'(Phosphodeoxyribomutase) PATH:ecs00030 2.3 K12661 rhmD LKrhamnonate'dehydratase'(RhamD)'(EC'4.2.1.90) PATH:ecs00051 2.4 K00932' tdcD Propionate'kinase'(EC'2.7.2.15) PATH:ecs00640 2.5 K00865' ybbZ Glycerate'kinase'(Putative'uncharacterized'protein'ybbZ) PATH:ece00630 2.6 K02745 NKacetylgalactosamineKspecific'PTS'system'enzyme'IIB'component PATH:ecs00052 2.7 K01643 Citrate'lyase'alpha'chain PATH:ecs00020 2.8 K00865 Putative'uncharacterized'protein'ECs4002 PATH:ecs00630 2.9 K02446 glpX PATH:ece00010 FructoseK1,6Kbisphosphatase PATH:ece00030 PATH:ece00051 2.10 K00705' malQ 4KalphaKglucanotransferase'(4KalphaKglucanotransferase'(Amylomaltase)) PATH:ece00500 2.11 K02777 crr PATH:ece00010'PATH:ece00500 GlucoseKspecific'PTS'system'IIA'component'(PTS'system,'glucoseKspecific'IIA' component) PATH:ece00520 2.12 K01653' ilvH PATH:ece00650 Acetolactate'synthase'III'small'subunit'(Acetolactate'synthase'III,'valine'sensitive,' small'subunit) PATH:ece00660 2.13 K10984' agaB GalactosamineKspecific'PTS'system'enzyme'IIB'component'(PTS'system,' PATH:ece00052 cytoplasmic,'NKacetylgalactosamineKspecific'IIB'component'1'(EIIBKAGA)) 2.14 K02821' yadI Putative'PTS'enzyme'II'B'component PATH:ece00053 2.15 K02768' fruB PATH:ecs00051

Multiphosphoryl'transfer'protein'(MTP)'(Phosphotransferase'FPr'protein)'(PseudoK HPr)'[Includes:'Phosphocarrier'protein'HPr'(Protein'H);'FructoseKspecific' phosphotransferase'enzyme'IIA'component'(EC'2.7.1.K)'(PTS'system'fructoseK specific'EIIA'component)]

K11183' 2.16 K02793 manX PATH:ecs00051

PTS'system'mannoseKspecific'EIIAB'component'(EIIABKMan)'[Includes:'MannoseK specific'phosphotransferase'enzyme'IIA'component'(EC'2.7.1.K)'(EIIIKMan)'(PTS' system'mannoseKspecific'EIIA'component);'MannoseKspecific'phosphotransferase' enzyme'IIB'component'(EC'2.7.1.69)'(PTS'system'mannoseKspecific'EIIB' component)]

K02794' PATH:ecs00520

3.#Energy#metabolism#(oxidative#phosphorylation#and#photosynthesis):

Serial#no. KEGG#orthology#number# Gene Pathway Protein#name (ko) 3.1 K00925 ackA'ack Acetate'kinase'(EC'2.7.2.1)'(Acetokinase) PATH:ecs00680 3.2 K00926 arcC Carbamate'kinase'(EC'2.7.2.2) PATH:ece00910 3.3 K01914 asnA AspartateKKammonia'ligase'(EC'6.3.1.1)'(Asparagine'synthetase'A) PATH:ecs00910 3.4 K00957' cysD Sulfate'adenylyltransferase'subunit'2'(EC'2.7.7.4)'(ATPKsulfurylase'small'subunit)' PATH:ecs00920 (Sulfate'adenylate'transferase)'(SAT) 3.5 K00651 metA Homoserine'OKsuccinyltransferase'(EC'2.3.1.46)'(Homoserine'OKtranssuccinylase)' PATH:ecs00920 (HTS) 3.6 K02446 glpX FructoseK1,6Kbisphosphatase PATH:ece00680 3.7 K00926' yahI Carbamate'kinase PATH:ece00910 3.8 K00926' yqeA Carbamate'kinase PATH:ece00910 3.9 'K02573 napG FerredoxinKtype'protein'(FerredoxinKtype'protein:'electron'transfer) PATH:ece00910 3.10 K01673 yadF Carbonic'anhydrase'(EC'4.2.1.1) PATH:ece00910

4.#Glycan#biosynthesis#and#metabolism#(peptidoglycan#biosynthesis):

Serial#no. KEGG#orthology#number# Gene Pathway Protein#name (ko) 4.1 K01929'' murF UDPKNKacetylmuramoylKtripeptideKKDKalanylKDKalanine'ligase'(EC'6.3.2.10) PATH:ece00550 4.2 K02841 rfaC PATH:ece00540 Heptosyl'transferase'I'(Heptosyl'transferase'I;'lipopolysaccharide'core'biosynthesis) 4.3 K02844 rfaG Glucosyltransferase'I'(Glucosyltransferase'I;'lipopolysaccharide'core'biosynthesis) PATH:ece00540 4.4 K02843 rfaF ADPKheptoseKKlps'heptosyltransferase'II'(ADPKheptoseKKlps'heptosyltransferase'II;' PATH:ece00540 lipopolysaccharide'core'biosynthesis) 4.5 K03269 lpxH UDPK2,3Kdiacylglucosamine'hydrolase'(EC'3.6.1.54)'(UDPK2,3Kdiacylglucosamine' diphosphatase) PATH:ece00540 4.6 K02536 lpxD UDPK3KOK(3Khydroxymyristoyl)glucosamine'NKacyltransferase'(UDPK3KOK(3KOHC14)K PATH:ece00540 GlcN'NKacyltransferase)'(EC'2.3.1.191) 4.7 K00748' lpxB LipidKAKdisaccharide'synthase'(EC'2.4.1.182) PATH:ece00540

5.#Lipid#metabolism#(fatty#acid#biosynthesis#and#glycerophospholipid#metabolism):

Serial#no. KEGG#orthology#number# Gene Pathway Protein#name (ko) 5.1 K03621 plsX PATH:ecs00561

Phosphate'acyltransferase'(EC'2.3.1.n2)'(AcylKACP'phosphotransacylase)'(AcylK[acylK carrierKprotein]KKphosphate'acyltransferase)'(PhosphateKacylKACP'acyltransferase)

PATH:ecs00564 5.2 K00865' ybbZ Glycerate'kinase'(Putative'uncharacterized'protein'ybbZ) PATH:ece00561 5.3 K00865 Putative'uncharacterized'protein'ECs4002 PATH:ecs00561

6.#Metabolism#of#cofactors#and#vitamins#(one#carbon#pool#by#folate#and#folate#biosynthesis):

Serial#no. KEGG#orthology#number# Gene Pathway Protein#name (ko) 6.1 K02492' hemA GlutamylKtRNA'reductase'(GluTR)'(EC'1.2.1.70) PATH:ecs00860 6.2 K01687 ilvD DihydroxyKacid'dehydratase'(DAD)'(EC'4.2.1.9) PATH:ecs00770 6.3 K03637 moaC'chlA3 Molybdenum'cofactor'biosynthesis'protein'C PATH:ecs00790 6.4 K03517 nadA Quinolinate'synthase'A'(EC'2.5.1.72) PATH:ecs00760 6.5 K03147' thiC Phosphomethylpyrimidine'synthase'(EC'4.1.99.17)'(Hydroxymethylpyrimidine' PATH:ecs00730 phosphate'synthase)'(HMPKP'synthase)'(HMPKphosphate'synthase)'(HMPP' synthase)'(Thiamine'biosynthesis'protein'ThiC) 6.6 K03149' thiG Thiazole'synthase'(EC'2.8.1.10) PATH:ecs00730 6.7 K00946' thiL ThiamineKmonophosphate'kinase'(TMP'kinase)'(ThiamineKphosphate'kinase)'(EC' PATH:ecs00730 2.7.4.16) 6.8 K03182' ubiD 3KoctaprenylK4Khydroxybenzoate'carboxyKlyase'(EC'4.1.1.K)'(Polyprenyl'pK PATH:ecs00130 hydroxybenzoate'decarboxylase) 6.9 K02552' Isochorismate'hydroxymutase'2 PATH:ecs00130 6.10 K01653' ilvH Acetolactate'synthase'III'small'subunit'(Acetolactate'synthase'III,'valine'sensitive,' PATH:ece00770 small'subunit) 6.11 K00798' Putative'cob(I)alamin'adenosyltransferase'(Putative'corrinoid:ATP' PATH:ece00860 adenosyltransferase) 6.12 K00798' btuR Cob(I)alamin'adenolsyltransferase PATH:ece00860 6.13 K11752' ribD Bifunctional'pyrimidine'deaminase/reductase'in'pathway'of'riboflavin'synthesis PATH:ece00740

7.#Metabolism#of#other#amino#acids#(selenocompound#metabolism,#DOglutamine#and#DOglutamate#metabolism,#and#DOalanine#metabolism):

Serial#no. KEGG#orthology#number# Gene Pathway Protein#name (ko) 7.1 K00925 ackA'ack Acetate'kinase'(EC'2.7.2.1)'(Acetokinase) PATH:ecs00430 7.2 K01914 asnA AspartateKKammonia'ligase'(EC'6.3.1.1)'(Asparagine'synthetase'A) PATH:ecs00460 7.3 K00957' cysD Sulfate'adenylyltransferase'subunit'2'(EC'2.7.7.4)'(ATPKsulfurylase'small'subunit)' PATH:ecs00450 (Sulfate'adenylate'transferase)'(SAT) 7.4 K01776' murI Glutamate'racemase'(EC'5.1.1.3) PATH:ecs00471 7.5 K12529' ygfM Uncharacterized'protein'YgfM PATH:ecs00450 7.6 K01270 pepD AminoacylKhistidine'dipeptidase'(Peptidase'D)'(AminoacylKhistidine'dipeptidase' PATH:ece00480 PepD) 7.7 K03823 Putative'resistance'protein PATH:ece00440

8.#Nucleotide#metabolism#(pyrimidine#and#purine#metabolism):

Serial#no. KEGG#orthology#number# Gene Pathway Protein#name (ko) 8.1 K00926 arcC Carbamate'kinase'(EC'2.7.2.2) PATH:ece00230 8.2 K00957' cysD Sulfate'adenylyltransferase'subunit'2'(EC'2.7.7.4)'(ATPKsulfurylase'small'subunit)' PATH:ecs00230 (Sulfate'adenylate'transferase)'(SAT) 8.3 K01839' deoB'drm'thyR Phosphopentomutase'(EC'5.4.2.7)'(Phosphodeoxyribomutase) PATH:ecs00230 8.4 K02337' dnaE PATH:ecs00230 DNA'polymerase'III'subunit'alpha'(EC'2.7.7.7) PATH:ecs00240 8.5 K01524' gppA GuanosineK5'Ktriphosphate,3'Kdiphosphate'pyrophosphatase'(EC'3.6.1.40)' PATH:ecs00230 (Guanosine'pentaphosphate'phosphohydrolase)'(pppGppK5'Kphosphohydrolase) 8.6 K04765 mazG PATH:ecs00230 Nucleoside'triphosphate'pyrophosphohydrolase'(NTPKPPase)'(EC'3.6.1.8) PATH:ecs00240 8.7 K01524' ppx Exopolyphosphatase'(ExopolyPase)'(EC'3.6.1.11)'(Metaphosphatase) PATH:ecs00230 8.8 K03060' rpoZ PATH:ecs00230

DNAKdirected'RNA'polymerase'subunit'omega'(RNAP'omega'subunit)'(EC'2.7.7.6)' (RNA'polymerase'omega'subunit)'(Transcriptase'subunit'omega)

PATH:ecs00240 8.9 K11178' yagS Putative'xanthine'dehydrogenase'YagS'FADKbinding'subunit'(EC'1.17.1.4) PATH:ecs00230 8.10 K00926' yahI Carbamate'kinase PATH:ece00230 8.11 K02339' holC PATH:ece00230 DNA'polymerase'III'chi'subunit'(DNA'polymerase'III,'chi'subunit) PATH:ece00240 8.12 K00926' yqeA Carbamate'kinase PATH:ece00230 8.13 K09903 pyrH Uridylate'kinase'(UK)'(EC'2.7.4.22)'(Uridine'monophosphate'kinase)'(UMP'kinase)' PATH:ecs00240 (UMPK)

9.#Genetic#information#processing#(transcription,#translation,#folding,#sorting#and#degradation,#and#replication#and#repair):

Serial#no. KEGG#orthology#number# Gene Pathway Protein#name (ko) 9.1 K02316 dnaG DNA'primase'(EC'2.7.7.K) PATH:ecs03030 9.2 K03629'' recF'uvrF DNA'replication'and'repair'protein'RecF PATH:ecs03440 9.3 K02863'' rplA 50S'ribosomal'protein'L1 PATH:ecs03010 9.4 K02895'' rplX 50S'ribosomal'protein'L24 PATH:ecs03010 9.5 K02897'' rplY 50S'ribosomal'protein'L25 PATH:ecs03010 9.6 K02902'' rpmB 50S'ribosomal'protein'L28 PATH:ecs03010 9.7 K02904'' rpmC 50S'ribosomal'protein'L29 PATH:ecs03010 9.8 K02907'' rpmD 50S'ribosomal'protein'L30 PATH:ecs03010 9.9 K02909'' rpmE 50S'ribosomal'protein'L31 PATH:ecs03010 9.10 K02916'' rpmI 50S'ribosomal'protein'L35 PATH:ecs03010 9.11 K02933'' rplF 50S'ribosomal'protein'L6 PATH:ecs03010 9.12 K08311'' rppH RNA'pyrophosphohydrolase'(EC'3.6.1.K)'((Di)nucleoside'polyphosphate'hydrolase) PATH:ecs03018 9.13 K02968'' rpsT 30S'ribosomal'protein'S20 PATH:ecs03010 9.14 K02970'' rpsU 30S'ribosomal'protein'S21 PATH:ecs03010 9.15 K02990'' rpsF 30S'ribosomal'protein'S6 PATH:ecs03010 9.16 K03550'' ruvA Holliday'junction'ATPKdependent'DNA'helicase'RuvA'(EC'3.6.4.12) PATH:ecs03440 9.17 K01159'' ruvC Crossover'junction'endodeoxyribonuclease'RuvC'(EC'3.1.22.4)'(Holliday'junction' PATH:ecs03440 nuclease'RuvC)'(Holliday'junction'resolvase'RuvC) 9.18 K01878'' glyQ PATH:ecs00970 GlycineKKtRNA'ligase'alpha'subunit'(EC'6.1.1.14)'(GlycylKtRNA'synthetase'alpha' subunit)'(GlyRS) 9.19 K01879'' glyS PATH:ecs00970 GlycineKKtRNA'ligase'beta'subunit'(EC'6.1.1.14)'(GlycylKtRNA'synthetase'beta' subunit)'(GlyRS) 9.20 K06223 dam DNA'adenine'methylase'(EC'2.1.1.72)'(DNA'adenine'methyltransferase)' PATH:ecs03430 (DeoxyadenosylKmethyltransferase) 9.21 K02337'' dnaE PATH:ecs03030 DNA'polymerase'III'subunit'alpha'(EC'2.7.7.7) PATH:ecs03430 PATH:ecs03440 9.22 K03666 hfq Protein'hfq'(HFK1)'(Host'factorKI'protein)'(HFKI) PATH:ecs03018 9.23 K03637 moaC'chlA3 Molybdenum'cofactor'biosynthesis'protein'C PATH:ecs04122 9.24 K03060'' rpoZ DNAKdirected'RNA'polymerase'subunit'omega'(RNAP'omega'subunit)'(EC'2.7.7.6)' PATH:ecs03020 (RNA'polymerase'omega'subunit)'(Transcriptase'subunit'omega) 9.25 K03071'' secB ProteinKexport'protein'SecB PATH:ecs03060 9.26 K04085'' tusA Sulfurtransferase'TusA'(EC'2.8.1.K)'(tRNA'2Kthiouridine'synthesizing'protein'A) PATH:ecs04122 9.27 K07235'' tusD Sulfurtransferase'TusD'(EC'2.8.1.K)'(tRNA'2Kthiouridine'synthesizing'protein'D) PATH:ecs04122 9.'28 K11179'' tusE Sulfurtransferase'TusE'(EC'2.8.1.K)'(tRNA'2Kthiouridine'synthesizing'protein'E) PATH:ecs04122 9.29 K03657'' uvrD PATH:ece03420 DNAKdependent'ATPase'I'and'helicase'II PATH:ece03430 9.30 K04067 Primosomal'replication'protein'N'' PATH:ecs03440 9.31 K01141 Exonuclease'I PATH:ecs03430 9.32 K02314 Replication'protein'P PATH:ecs03030 9.33 K02339'' holC PATH:ece03030 DNA'polymerase'III'chi'subunit'(DNA'polymerase'III,'chi'subunit) PATH:ece03430'PATH:ece03440 9.34 K03583'' recC DNA'helicase'RecC'(DNA'helicase,'ATPKdependent'dsDNA/ssDNA'exonuclease'V' PATH:ece03440 subunit,'ssDNA'endonuclease)

10.#Environmental#information#processing#(membrane#transport#and#signal#transduction):

Serial#no. KEGG#orthology#number# Gene Pathway Protein#name (ko) 10.1 K03071'' secB ProteinKexport'protein'SecB PATH:ecs03070 10.2 K02745 NKacetylgalactosamineKspecific'PTS'system'enzyme'IIB'component PATH:ecs02060 10.3 K01643 Citrate'lyase'alpha'chain PATH:ecs02020 10.4 K02777 crr GlucoseKspecific'PTS'system'IIA'component'(PTS'system,'glucoseKspecific'IIA' PATH:ece02060 component) 10.5 K10984'' agaB GalactosamineKspecific'PTS'system'enzyme'IIB'component'(PTS'system,' PATH:ece02060 cytoplasmic,'NKacetylgalactosamineKspecific'IIB'component'1'(EIIBKAGA)) 10.6 K02821 yadI Putative'PTS'enzyme'II'B'component PATH:ece02060 10.7 K02768'' fruB PATH:ecs02060

Multiphosphoryl'transfer'protein'(MTP)'(Phosphotransferase'FPr'protein)'(PseudoK HPr)'[Includes:'Phosphocarrier'protein'HPr'(Protein'H);'FructoseKspecific' phosphotransferase'enzyme'IIA'component'(EC'2.7.1.K)'(PTS'system'fructoseK specific'EIIA'component)]

K11183'' 10.8 K02793 manX PATH:ecs02060

PTS'system'mannoseKspecific'EIIAB'component'(EIIABKMan)'[Includes:'MannoseK specific'phosphotransferase'enzyme'IIA'component'(EC'2.7.1.K)'(EIIIKMan)'(PTS' system'mannoseKspecific'EIIA'component);'MannoseKspecific'phosphotransferase' enzyme'IIB'component'(EC'2.7.1.69)'(PTS'system'mannoseKspecific'EIIB' component)]

K02794'' 10.9 K07773' arcA Aerobic'respiration'control'protein'ArcA PATH:ece02020 10.10 K07664 Transcriptional'response'regulatory'protein PATH:ecs02020 10.11 K03407 cheA Sensory'transducer'kinase'CheA'(Sensory'transducer'kinase'between'chemoKsignal' receptors'and'CheB'and'CheY) PATH:ece02020 10.12 K07685 narP Nitrate/nitrite'response'regulator'(Sensor'NarQ)'(Nitrate/nitrite'response'regulator' PATH:ece02020 NarP) 10.13 K02806'' ptsN Phosphotransferase'system'enzyme'IIA'(Phosphotransferase'system'enzyme'IIA,' PATH:ece02060 regulates'N'metabolism) 10.14 K07771 basR 2Kcomponent'regulatory'system'regulatory'protein'BasR'(Transcriptional'regulatory' protein'2Kcomponent'regulatory'system'member)

PATH:ece02020 10.15 K03092 rpoN RNA'polymerase'sigmaK54'factor PATH:ece02020 10.16 K07663 creB Catabolic'regulation'response'regulator PATH:ece02020 10.17 K07661 rstA Response'transcriptional'regulatory'protein'(RstB'sensor)'(Response'transcriptional' PATH:ece02020 regulatory'protein'RstB'sensor) 10.18 K07667 kdpE Regulator'of'kdp'operon'(Transcriptional'effector)'(Transcriptional'regulator'of'kdp' operon) PATH:ece02020 10.19 K07772 torR TorCAD'operon'transcriptional'regulatory'protein'TorR PATH:ece02020 10.20 K03533 torD Chaperone'protein'TorD PATH:ece02020 10.21 K07666 qseB Transcriptional'regulatory'protein'QseB PATH:ece02020 10.22 K02759 chbA''celC N,N'KdiacetylchitobioseKspecific'phosphotransferase'enzyme'IIA'component'(EC' PATH:ece02060 2.7.1.K)'(EIIAKChb)'(EIIIKChb)'(PTS'system'N,N'KdiacetylchitobioseKspecific'EIIA' component) 10.23 K02784 ptsH Phosphocarrier'protein'HPr'(EC'2.7.11.K)'(HistidineKcontaining'protein) PATH:ece02060 10.24 K07660 phoP Transcriptional'regulatory'protein'PhoP PATH:ece02020 10.25 K07657 phoB Phosphate'regulon'transcriptional'regulatory'protein'PhoB PATH:ece02020 10.26 K07659'' ompR Transcriptional'regulatory'protein'OmpR PATH:ece02020 10.27 K07684'' narL Nitrate/nitrite'response'regulator'protein'NarL PATH:ece02020 10.28 K07665 cusR Transcriptional'regulatory'protein'CusR PATH:ece02020 10.29 K03408 cheW Chemotaxis'protein'CheW PATH:ece02020 10.30 K02464 etpN Type'4'prepilinKlike'proteins'leader'peptideKprocessing'enzyme'(EC'2.1.1.K) PATH:ecs03070

11.'Cellular#Processes:

Serial#no. KEGG#orthology#number# Gene Pathway Protein#name (ko) 11.1 K03407 cheA Sensory'transducer'kinase'CheA'(Sensory'transducer'kinase'between'chemoKsignal' PATH:ece02030 receptors'and'CheB'and'CheY) 11.2 K02413 fliJ Flagellar'fliJ'protein PATH:ece02040

12.#Others:

Serial#no. KEGG#orthology#number# Gene Pathway Protein#name (ko) 12.1 K03526 ispG'gcpE 4KhydroxyK3KmethylbutK2KenK1Kyl'diphosphate'synthase'(EC'1.17.7.1)'(1KhydroxyK2K PATH:ecs00900 methylK2K(E)Kbutenyl'4Kdiphosphate'synthase) 12.2 K02552 Isochorismate'hydroxymutase'2 PATH:ecs01053 Species used as references to find out broad spectrum targets

Bacillus(anthracis(str(A0248 Bordetella(pertussis(Tohama(I Borrelia(garinii(Pbi Brucella(abortus(bv(1(str(9?941 Brucella(melitensis(16M Brucella(melitensis(ATCC(23457( Brucella(suis(1330( Brucella(suis(ATCC(23445( Burkholderia(ambifaria(MC40?6( Burkholderia(cenocepacia(AU(1054( Burkholderia(mallei(ATCC(23344( Burkholderia(pseudomallei(K96243( Campylobacter(jejuni(subsp(doylei(26997( Campylobacter(jejuni(subsp(jejuni(81116( Campylobacter(jejuni(subsp(jejuni(M1( Chlamydophila(abortus(S263( Chlamydophila(felis(FeC?56( Clostridium(botulinum(A2(str(Kyoto( Clostridium(cf(saccharolyticum(K10( Clostridium(perfringens(SM101( Clostridium(perfringens(str(13( Clostridium(tetani(E88( Corynebacterium(diphtheriae(NCTC(13129((( Coxiella(burnetii(CbuK(Q154( Coxiella(burnetii(RSA(331( Ehrlichia(canis(str(Jake( Ehrlichia(chaffeensis(str(Arkansas( Ehrlichia(ruminantium(str(Gardel( Escherichia(coli(536( Escherichia(coli(O55?H7(str(CB9615( Escherichia(coli(O157?H7(EDL933((( Escherichia(coli(O157?H7(str(TW14359( Escherichia(coli(TY?2482.PATRIC Escherichia(coli(UMNK88( Francisella(philomiragia(subsp(philomiragia((ATCC(25017( Francisella(tularensis(subsp(tularensis((WY96?3418( Haemophilus(influenzae(Rd(KW20((( Helicobacter(acinonychis(str(Sheeba( Helicobacter(pylori(83( Legionella(pneumophila(str(Lens((( Listeria(monocytogenes(08?5923.PATRIC Listeria(monocytogenes(str(4b(F2365( Mycobacterium(leprae(Br4923( Mycobacterium(tuberculosis(CCDC5180( Neisseria(meningitidis(MC58((( Neisseria(meningitidis(Z2491((( Pseudomonas(aeruginosa(PAO1((( Rickettsia(conorii(str(Malish(7( Rickettsia(prowazekii(str(Madrid(E( Rickettsia(typhi(TH1527( Salmonella(enterica(subsp(enterica(serovar(((Paratyphi(A(str(AKU(12601 Salmonella(enterica(subsp(enterica(serovar(((Schwarzengrund(str(CVM19633( Salmonella(enterica(subsp(enterica(serovar((Typhi(str(Ty2( Shigella(boydii(CDC(3083?94( Shigella(dysenteriae(Sd197( Shigella(flexneri(2a(str(301( Shigella(sonnei(Ss046( Staphylococcus(aureus(RF122( Staphylococcus(aureus(subsp(aureus(JH9( Staphylococcus(aureus(subsp(aureus(str(JKD6008( Staphylococcus(aureus(subsp(aureus(TCH60( Streptococcus(pneumoniae(AP200( Streptococcus(pyogenes(MGAS10394( Streptococcus(suis(BM407( Vibrio(cholerae(M66?2( Vibrio(cholerae(MJ?1236( Vibrio(cholerae(O1(biovar(El(Tor(str(N16961( Vibrio(cholerae(O395( Vibrio(harveyi(ATCC(BAA?1116( Vibrio(parahaemolyticus(RIMD(2210633( Yersinia(pestis(CO92( Yersinia(pestis(D182038( Yersinia(pseudotuberculosis(IP(32953( List of 44 proteins found to be broad spectrum targets

Uniprot ID Protein Name and EC Number Gene Name Length Protein Existence In Pathways Q8X8X5 DNA polymerase III subunit alpha (EC 2.7.7.7) dnaE Z0196 ECs0186 1160 Inferred from homology 6 P0A6A5 Acetate kinase (EC 2.7.2.1) (Acetokinase) ackA ack Z3558 ECs3180 400 Inferred from homology 6 Q8XCV5 Carbamate kinase (EC 2.7.2.2) arcC Z0676 ECs0583 297 Inferred from homology 4 Q8XAV1 Dihydroxy-acid dehydratase (DAD) (EC 4.2.1.9) ilvD Z5282 ECs4705 616 Inferred from homology 4 P69799 PTS system mannose-specific EIIAB component (EC 2.7.1.-) manX Z2860 ECs2527 323 Inferred from homology 4 Q8XD78 Carbamate kinase yqeA ECs3747 Z4213 310 Inferred from homology 4 Q8X6A8 Carbamate kinase yahI ECs0372 Z0412 316 Inferred from homology 4 P58237 Imidazole glycerol phosphate synthase subunit HisH (EC 2.4.2.-) hisH Z3185 ECs2824 196 Inferred from homology 3 P60665 Imidazole glycerol phosphate synthase subunit HisF (EC 4.1.3.-) hisF Z3187 ECs2826 258 Inferred from homology 3 P0A740 Molybdenum cofactor biosynthesis protein C moaC chlA3 Z1002 ECs0861 161 Inferred from homology 3 P65737 Phosphate acyltransferase (EC 2.3.1.n2) plsX Z1729 ECs1468 356 Inferred from homology 3 P0A7F1 Uridylate kinase (UK) (EC 2.7.4.22) pyrH Z0182 ECs0173 241 Inferred from homology 2 Q8X6X9 Phosphomethylpyrimidine synthase (EC 4.1.99.17) thiC Z5569 ECs4917 631 Inferred from homology 2 P58263 Thiazole synthase (EC 2.8.1.10) thiG Z5565 ECs4914 256 Inferred from homology 2 P0A9Q3 Aerobic respiration control protein ArcA arcA Z6004 ECs5359 238 Inferred from homology 1 P0AD00 Transcriptional regulatory protein CusR cusR Z0709 ECs0609 227 Inferred from homology 1 P0AF30 Nitrate/nitrite response regulator protein NarL narL Z1996 ECs1726 216 Inferred from homology 1 P0AA18 Transcriptional regulatory protein OmpR ompR Z4760 ECs4247 239 Inferred from homology 1 P0AFJ6 Phosphate regulon transcriptional regulatory protein phoB phoB Z0497 ECs0449 229 Inferred from homology 1 Q8X738 Transcriptional regulatory protein phoP phoP Z1859 ECs1602 223 Inferred from homology 1 P0ABS6 DNA primase (EC 2.7.7.-) dnaG Z4419 ECs3949 581 Inferred from homology 1 Q8XBS3 Transcriptional regulatory protein qseB qseB Z4377 ECs3907 219 Evidence at transcript level 1 P0A7L2 50S ribosomal protein L1 rplA Z5557 ECs4907 234 Inferred from homology 1 P0AG57 50S ribosomal protein L6 rplF Z4675 ECs4170 177 Evidence at protein level 1 P0A811 Holliday junction ATP-dependent DNA helicase RuvA (EC 3.6.4.12) ruvA Z2913 ECs2571 203 Inferred from homology 1 P67026 Glycine--tRNA ligase alpha subunit (EC 6.1.1.14) glyQ Z4984 ECs4443 303 Inferred from homology 1 Q8XAF1 Propionate kinase (EC 2.7.2.15) tdcD Z4467 ECs3995 402 Inferred from homology 1 P58357 TorCAD operon transcriptional regulatory protein torR torR Z1412 ECs1150 230 Inferred from homology 1 Q8X770 Response transcriptional regulatory protein (RstB sensor) rstA ECs2314 Z2609 242 Predicted Q8XE88 Bifunctional pyrimidine deaminase/reductase in pathway of riboflavin synthesis ribD ECs0467 Z0515 367 Predicted Q8XB09 Catabolic regulation response regulator creB ECs5356 Z6001 229 Predicted Q8X726 Putative amino acid amidohydrolase (Putative hippuricase) ECs4892 Z5522 388 Predicted Q8XDU4 2-component regulatory system regulatory protein BasR basR ECs5095 Z5715 222 Predicted Q8XE66 Nitrate/nitrite response regulator (Sensor NarQ) narP ECs3082 Z3450 215 Predicted Q8X6S0 L-serine dehydratase (L-serine dehydratase (Deaminase) sdaB ECs3657 Z4114 455 Predicted Q8X8P5 DNA-dependent ATPase I and helicase II uvrD ECs4743 Z5330 720 Predicted Q8X9G2 Regulator of kdp operon (Transcriptional effector) kdpE ECs0722 Z0841 225 Predicted Q8XCW0 Glycerate kinase (Putative uncharacterized protein ybbZ) ybbZ ECs0576 Z0669 381 Predicted Q8X9Z5 Acetolactate synthase III small subunit ilvH ECs0082 Z0088 163 Predicted Q8XBL1 Glucose-specific PTS system IIA component crr ECs3289 Z3683 169 Predicted Q7ACL8 Transcriptional response regulatory protein ECs2887 240 Predicted Q7AAL3 Putative uncharacterized protein ECs4002 ECs4002 408 Predicted Q7AAL9 L-serine deaminase ECs3992 454 Predicted Q7AD93 L-serine deaminase ECs2523 454 Predicted